Moderate Risk QTc-Prolonging Agents

Drugs that have demonstrated moderate QTc interval prolongation in either animal or human studies.
DrugDrug NameDrug Indication
DB00007LeuprolideFor treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
DB00014GoserelinGoserelin is indicated for: - Use in combination with flutamide for the management of locally confined carcinoma of the prostate - Palliative treatment of advanced carcinoma of the prostate - The management of endometriosis - Use as an endometrial-thinning agent prior to endometrial ablation for dysfunctional uterine bleeding - Use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women
DB00199Erythromycin Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below [FDA label]: _Respiratory infections_ **Upper respiratory tract infections** of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H. influenzae are not susceptible to the erythromycin concentrations ordinarily achieved) [FDA label]. **Lower-respiratory tract infections** of mild to moderate severity caused by Streptococcus pneumoniae or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes [FDA label]. **Pertussis (whooping cough)** caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals [FDA label]. **Respiratory tract infections** due to Mycoplasma pneumoniae [FDA label]. **Legionnaires’ Disease** caused by Legionella pneumophila. Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires’ Disease [FDA label]. **Diphtheria**: Infections due to Corynebacterium diphtheriae, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers [FDA label]. _Skin infections_ **Skin and skin structure infections** of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment) [FDA label]. **Erythrasma**: In the treatment of infections due to Corynebacterium minutissimum [FDA label]. _Gastrointestinal infections_ **Intestinal amebiasis** caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents [FDA label]. _Genital infections/STIs_ **Acute pelvic inflammatory disease** caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N. gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months [FDA label]. **Syphilis** caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy [FDA label]. **Chlamydia trachomatis**: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis [FDA label]. **Nongonnoconnal urethritis**: When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum [FDA label].
DB00207AzithromycinAzithromycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria in order to prevent the development antimicrobial resistance and maintain the efficacy of azithromycin [FDA label]. Azithromycin is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the microorganisms listed in the specific conditions below. Recommended dosages, duration of therapy and considerations for various patient populations may vary among these infections. Refer to the FDA label and "Indications" section of this drug entry for detailed information [FDA label]. **Adults**: Acute bacterial exacerbations of chronic obstructive pulmonary disease due to _Haemophilus influenzae_, _Moraxella catarrhalis_ or _Streptococcus pneumoniae_ Acute bacterial sinusitis due to _Haemophilus influenzae_, _Moraxella catarrhalis_ or _Streptococcus pneumoniae_ Community-acquired pneumonia due to _Chlamydophila pneumoniae_, _Haemophilus influenzae_, _Mycoplasma pneumoniae_ or _Streptococcus pneumoniae_ in patients appropriate for oral therapy Pharyngitis/tonsillitis caused by _Streptococcus pyogenes_ as an alternative to first-line therapy in individuals who cannot use first-line therapy. Uncomplicated skin and skin structure infections due to _Staphylococcus aureus_, _Streptococcus pyogenes_, or _Streptococcus agalactiae_. Abscesses usually require surgical drainage. Urethritis and cervicitis due to _Chlamydia trachomatis_ or _Neisseria gonorrhoeae_. Genital ulcer disease in men due to _Haemophilus ducreyi_ (chancroid). Due to the small number of women included in clinical trials, the efficacy of azithromycin in the treatment of chancroid in women has not been established. **Pediatric Patients** Acute otitis media caused by _Haemophilus influenzae_, _Moraxella catarrhalis_ or _Streptococcus pneumoniae_ Community-acquired pneumonia due to _Chlamydophila pneumoniae_, _Haemophilus influenzae_, _Mycoplasma pneumoniae_ or _Streptococcus pneumoniae_ in patients appropriate for oral therapy. Pharyngitis/tonsillitis caused by _Streptococcus pyogenes_ as an alternative to first-line therapy in individuals who cannot use first-line therapy.
DB00218MoxifloxacinFor the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
DB00263SulfisoxazoleFor the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
DB00333MethadoneFor the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain.
DB00363ClozapineFor use in patients with treatment-resistant schizophrenia.
DB00420PromazineUsed as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
DB00450DroperidolDroperidol is ssed to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
DB00477ChlorpromazineFor the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.
DB00502HaloperidolFor the treatment of schizophrenia [L2016] For the treatment of acute psychosis in acutely agitated schizophrenic patients with moderately severe to very severe symptoms [L2016] For the treatment of severe behavioral or psychological symptoms of dementia [L2016] For the treatment of delirium in the pediatric intensive care unit [L2016] For the treatment of agitation or delirium [L2016] For agitation† or delirium in adult patients with no underlying psychiatric illness [L2016] For use as a second-line agent for rescue treatment of chemotherapy-induced nausea/vomiting [L2016] For the treatment of irritability associated with autistic disorder [L2016] For the treatment of tics and vocal utterances associated with Tourette's syndrome [L2016] For the treatment of severe behavioral problems associated with oppositional defiant disorder or other disruptive behavioral disorders, or for the treatment of attention-deficit hyperactivity disorder (ADHD) in pediatric patients who show excessive motor activity with accompanying conduct disorders [L2016]
DB00537CiprofloxacinCiprofloxacin is only indicated in infections caused by susceptible bacteria.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] Ciprofloxacin immediate release tablets, oral suspensions, and intravenous injections are indicated for the treatment of skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections, nosocomial pneumonia, febrile neutropenia, adults who have inhaled anthrax, plague, chronic bacterial prostatitis, lower respiratory tract infections including acute exacerbations of chronic bronchitis, urinary tract infections, complicated urinary tract infections in pediatrics, complicated pyelonephritis in pediatrics, and acute sinusitis.[L6481,L6478] A ciprofloxacin otic solution and otic suspension with hydrocortisone are indicated for acute otitis externa.[L6469,L6484] Ciprofloxacin suspension with dexamethasone is indicated for acute otitis media in pediatric patients with tympanostomy tubes or acute otitis externa.[L6490] A ciprofloxacin intratympanic injection is indicated for pediatric patients with bilateral otitis media with effusion who are having tympanostomy tubes placed or pediatric patients 6 months or older with acute otitis externa.[L6493] A ciprofloxacin eye drop is indicated for bacterial corneal ulcers and conjunctivitis.[L6472] A ciprofloxacin eye ointment is indicated for bacterial conjunctivitis.[L6475] A ciprofloxacin extended release tablet is indicated for uncomplicated urinary tract infections, complicated urinary tract infections, and acute uncomplicated pyelonephritis.[L6487]
DB00556PerflutrenUsed as an ultrasound contrast imaging in cardiology and radiology.
DB00608ChloroquineFor the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis
DB00738PentamidineFor the treatment of pneumonia due to Pneumocystis carinii.
DB00743Gadobenic acidGadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
DB00757DolasetronFor the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses of chemotherapy. Also used for the prevention of postoperative nausea and vomiting. This drug can be used intravenously for the treatment of postoperative nausea and vomiting.
DB00889GranisetronFor the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
DB00904OndansetronIn the adult patient population: i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for: - the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and - the prevention and treatment of postoperative nausea and vomiting ii) intravenously administered ondansetron injection formulations are indicated for: - the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and - the prevention and treatment of postoperative nausea and vomiting In the pediatric (4-18 years of age) patient population: i) ondansetron was effective and well tolerated when given to children 4-12 years of age for the treatment of post-chemotherapy induced nausea and vomiting, ii) ondansetron tablets, ondansetron ODT, ondansetron injection are not indicated for the treatment of children 3 years of age or younger, iii) ondansetron tablets, ondansetron ODT, ondansetron injection are not indicated for use in any age group of the pediatric population for the treatment of post-radiotherapy induced nausea and vomiting, and iV) ondansetron tablets, ondansetron ODT, ondansetron injection are not indicated for use in any age group of the pediatric population for the treatment of postoperative nausea and vomiting In the geriatric (>65 years of age) patient population: i) efficacy and tolerance of ondansetron were similar to that observed in younger adults for the treatment of post-chemotherapy and radiotherapy-induced nausea and vomiting, and ii) clinical experience in the use of ondansetron in the prevention and treatment of postoperative nausea and vomiting is limited and is not indicated for use in the geriatric patient population
DB00976TelithromycinFor the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
DB01087PrimaquineFor the treatment of malaria.
DB01137LevofloxacinFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
DB01155GemifloxacinFor the treatment of bacterial infection caused by susceptible strains such as S. pneumoniae, H. influenzae, H. parainfluenzae, or M. catarrhalis, S. pneumoniae (including multi-drug resistant strains [MDRSP]), M. pneumoniae, C. pneumoniae, or K. pneumoniae.
DB01165OfloxacinFor the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
DB01182PropafenoneUsed to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
DB01195FlecainideFlecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin.
DB01211ClarithromycinAn alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for Mycobacterium avium complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection).
DB01232SaquinavirFor the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
DB06402TelavancinFor the treatment of complicated skin and skin structure infections (cSSSI) caused by gram-positive bacteria like methicillin-susceptible or -resistant Staphylococcus aureus, vancomycin-susceptible Enterococcus faecalis, and Streptococcus pyogenes, Streptococcus agalactiae, or Streptococcus anginosus group. Also for the treatment of adult patients with hospital-acquired bacterial pneumonia (HAP) and ventilator-associated bacterial pneumonia (VAP), known or suspected to be caused by susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant S. aureus).
DB06589PazopanibTreatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
DB06603PanobinostatPanobinostat is indicated in the treatment of multiple myeloma in combination with dexamethasone and bortezomib in patients who have received 2 previous treatment regimens including bortezomib and an immunomodulatory agent. This indication is approved by accelerated approval based on progression free survival as of February 23, 2015.
DB08865CrizotinibCrizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
DB08903BedaquilineBedaquiline is indicated as part of combination therapy in adults (≥ 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB).
DB09063CeritinibCeritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response. An improvement in survival or disease-related symptoms has not been established. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.
DB09078LenvatinibLenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
DB00321AmitriptylineThis drug in indicated for the following conditions [FDA label]: Major depressive disorder in adults Management of neuropathic pain in adults Prophylactic treatment of chronic tension-type headache (CTTH) in adults Prophylactic treatment of migraine in adults Treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis [FDA label] Off-label uses: irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation, fibromyalgia, and insomnia
DB00458ImipramineFor the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older [FDA Label]. May also be used off-label to manage panic disorders with or without agoraphobia, as a second line agent for ADHD in children and adolescents, to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy [L1349,L1348,A31900,L1351,L1352,L1353,A31904].
DB01242ClomipramineMay be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include: depression, panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy (limited evidence), autistic disorder (limited evidence), trichotillomania (limited evidence), onchophagia (limited evidence), stuttering (limited evidence), premature ejaculation, and premenstrual syndrome.
DB12565AbexinostatNot Available
DB12174CUDC-101Not Available
DB11841EntinostatNot Available
DB11830MocetinostatNot Available
DB05223PracinostatFor the treatment of various forms of cancer.
DB12376RicolinostatNot Available
DB06334TucidinostatInvestigated for use/treatment in cancer/tumors (unspecified).
DB11637DelamanidIndicated for use as part of an appropriate combination regimen for pulmonary multi-drug resistant tuberculosis (MDR-TB) in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability [L1407].
DB06771BesifloxacinTreatment of bacterial conjunctivitis. Bacterial isolates that are susceptible to besifloxacin include: CDC coryneform group G; Corynebacterium pseudodiphtheriticum; Corynebacterium striatum; Haemophilus influenzae; Moraxella lacunata; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis; Staphylococcus lugdunensis; Streptococcus mitis group; Streptococcus oralis; Streptococcus pneumoniae; Streptococcus salivarius*
DB00827CinoxacinFor the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and Enterobacter species.
DB06160GarenoxacinInvestigated for use/treatment in bacterial infection.
DB00978LomefloxacinFor the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
DB00779Nalidixic acidFor the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.
DB06600NemonoxacinInvestigated for use/treatment in bacterial infection and pneumonia.
DB13261SitafloxacinNot Available
DB05488Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
DB01227LevacetylmethadolFor the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.
DB00391SulpirideSulpiride is indicated for the treatment of schizophrenia.
DB00933MesoridazineUsed in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
DB00526OxaliplatinUsed in combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum and for adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.
DB01113PapaverineFor the treatment of impotence and vasospasms.
DB01599ProbucolUsed to lower LDL and HDL cholesterol.
DB00778RoxithromycinUsed to treat respiratory tract, urinary and soft tissue infections.
DB13273SultoprideNot Available
DB02638TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
DB11640AmifampridineAmifampridine is indicated for the symptomatic treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults[F272] and in patients aged 6 to less than 17 years of age.[F4609,L6250] Nevertheless, it is important to note that at the current time only the Firdapse brand of amifampridine is indicated for the treatment of LEMS in adults[F272] and the Ruzurgi brand of amifampridine is indicated for the treatment of LEMS in patients aged 6 to less than 17 years.[F4609,L6250]
DB14568IvosidenibIvosidenib is approved for use in the treatment of relapsed or refractory AML with a susceptible IDH1 mutation as detected by an FDA-approved test [FDA Label].
DB11642PitolisantIndicated in adults for the treatment of narcolepsy with or without cataplexy [L1471].
DB01615AceprometazineAceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
DB08799AntazolineUsed to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
DB01114ChlorphenamineFor the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.
DB09016ButriptylineNot Available
DB00748CarbinoxamineFor symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. Also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
DB00568CinnarizineFor the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
DB00967DesloratadineFor the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
DB13679DexchlorpheniramineNot Available
DB09555Dexchlorpheniramine maleateDexchlorpheniramine can be used in the treatment of perennial and seasonal allergic rhinitis, vasomotor rhiniti, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, and dermographism.
DB00985DimenhydrinateDimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.
DB01084EmedastineFor the temporary relief of the signs and symptoms of allergic conjunctivitis.
DB00950FexofenadineFor management of Seasonal allergic rhinitis
DB00455LoratadineLoratadine is a 2nd generation antihistamine and is typically used to manage symptoms of allergic rhinitis, wheal formation and urticaria.[A176435][A176438] Unlike 1st generation antihistamines, loratadine is non-sedating since it has minimal effect on the central nervous system with only a small amount entering the brain. [A176438]
DB12877OxatomideNot Available
DB00544FluorouracilFor the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
DB01193AcebutololFor the management of hypertension and ventricular premature beats in adults.
DB00640AdenosineUsed as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
DB00572AtropineFor the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
DB04957AzimilideInvestigated for use/treatment in arrhythmia and atrial fibrillation.
DB09231BenidipineBenidipine is a potent and long-lasting drug indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris.[A31950]
DB00612BisoprololFor management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
DB00571PropranololFor the prophylaxis of migraine.
DB00195BetaxololFor the management of hypertension.
DB13652BunaftineNot Available
DB14063DexverapamilNot Available
DB00343Diltiazem**Oral** Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.[label] Indicated for use to improve exercise tolerance in patients with chronic stable angina.[label] Indicated for the management of variant angina (Prinzmetal's angina).[L6298] **Intravenous** Indicated for the short-term management of atrial fibrillation or atrial flutter for temporary control of rapid ventricular rate.[L6292] Indicated for the rapid conversion of paroxysmal supraventricular tachycardias (PSVT) to sinus rhythm. This includes AV nodal reentrant tachycardias and reciprocating tachycardias associated with an extranodal accessory pathway such as the WPW syndrome or short PR syndrome.[L6292] **Off-label** Indicated for off-label uses in anal fissures (as topical formulation), migraine prophylaxis, cramps in lower leg related to rest, pulmonary hypertension,[L6289] idiopathic dilated cardiomyopathy, and proteinuria associated with diabetic nephropathy.[L6298]
DB08992EperisoneNot Available
DB08980FendilineNot Available
DB04842FluspirileneUsed for the treatment of schizophrenia.
DB08952IndenololNot Available
DB00922LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
DB00836LoperamideFor the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
DB13653LorcainideNot Available
DB09224MelperoneFor the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322].
DB01388MibefradilFor the treatment of angina and high blood pressure.
DB01115NifedipineFor the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
DB06712NilvadipineFor the management of vasospastic angina, chronic stable angina and hypertension.
DB00393NimodipineFor use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.
DB13546NizofenoneNot Available
DB13500OtiloniumNot Available
DB01580OxprenololUsed in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
DB13791PenfluridolNot Available
DB04825PrenylamineNot Available
DB12286SimendanNot Available
DB06200TedisamilInvestigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
DB00625EfavirenzFor use in combination treatment of HIV infection (AIDS)
DB12523MizolastineNot Available
DB12141GilteritinibGilteritinib is indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia with an FLT3 mutation detected by an FDA-approved test. This indication was expanded for a companion diagnostic to include use with gilteritinib such as the LeukoStrat CDx FLT3 Mutation Assay.[L4830] Acute myeloid leukemia is cancer that impacts the blood and bone marrow with a rapid progression. This condition produces low numbers of normal blood cells and the requirement of continuous need for transfusions.[L4832]
DB00433ProchlorperazineFor the symptomatic management of psychotic disorders, short term management of nonpsychotic anxiety in patients with generalized anxiety disorder, and for the control of severe nausea and vomiting of various causes.
DB04948LofexidineLofexidine is indicated for mitigation of symptoms associated with acute withdrawal from opioids and for facilitation of the completion of opioid discontinuation treatment. It is the first non-opioid medication for the symptomatic management of opioid discontinuation.[L2801] Opioid withdrawal syndrome is a debilitating manifestation of opioid dependence.[A33085] This condition is extremely unpleasant lasting several days with some of the main features being abdominal pain, nausea, diarrhea, mydriasis, lacrimation, and piloerection. These symptoms are often observed after abrupt reductions in the opioid dose and can be resolved by re-administration of the opioid.[A33088]
DB00243RanolazineRanolazine is approved as a second-line agent in the management of chronic stable angina pectoris that is refractory to conventional anti-ischemic therapy.[A174913] Ranolazine has also been used off-label for the treatment of some arrhythmias such as ventricular tachycardia, however, this use does not have a lot of supporting evidence.[A174940] The use of ranolazine has been researched in the treatment of acute coronary syndrome, microvascular coronary dysfunction, arrhythmia, and glycemic control.[A174898]
DrugDrug NameTargetType
DB00007LeuprolideGonadotropin-releasing hormone receptortarget
DB00007LeuprolideCytochrome P450 3A4enzyme
DB00014GoserelinLutropin-choriogonadotropic hormone receptortarget
DB00014GoserelinGonadotropin-releasing hormone receptortarget
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinBacterial 50S Ribosomal Subunittarget
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00207Azithromycin23S rRNAtarget
DB00207AzithromycinMultidrug resistance protein 1transporter
DB00207AzithromycinCytochrome P450 3A4enzyme
DB00207AzithromycinProtein-arginine deiminase type-4target
DB00207AzithromycinCanalicular multispecific organic anion transporter 1transporter
DB00207AzithromycinBacterial 50S Ribosomal Subunittarget
DB00218MoxifloxacinDNA gyrase subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 4 subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 2-alphatarget
DB00218MoxifloxacinCytochrome P450 1A2enzyme
DB00263SulfisoxazoleDihydropteroate synthasetarget
DB00263SulfisoxazoleCytochrome P450 2C9enzyme
DB00333MethadoneGlutamate receptor ionotropic, NMDA 3Atarget
DB00333MethadoneMu-type opioid receptortarget
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-10target
DB00333MethadoneCytochrome P450 2B6enzyme
DB00333MethadoneCytochrome P450 3A4enzyme
DB00333MethadoneCytochrome P450 2C19enzyme
DB00333MethadoneDelta-type opioid receptortarget
DB00333MethadoneCytochrome P450 3A5enzyme
DB00333MethadoneCytochrome P450 3A7enzyme
DB00333MethadoneCytochrome P450 2D6enzyme
DB00333MethadoneMultidrug resistance protein 1transporter
DB00333MethadoneCytochrome P450 2C8enzyme
DB00333MethadoneCytochrome P450 19A1enzyme
DB00333MethadoneCytochrome P450 1A2enzyme
DB00333MethadoneCytochrome P450 2C18enzyme
DB00333MethadoneCytochrome P450 2C9enzyme
DB00333Methadone5-hydroxytryptamine receptor 3Atarget
DB00333MethadoneLymphocyte antigen 96target
DB00333MethadoneAlpha-1-acid glycoprotein 2target
DB00333MethadoneThyroxine-binding globulincarrier
DB00363ClozapineD(4) dopamine receptortarget
DB00363ClozapineHistamine H1 receptortarget
DB00363ClozapineD(2) dopamine receptortarget
DB00363ClozapineNeuron-specific vesicular protein calcyontarget
DB00363ClozapineHistamine H4 receptortarget
DB00363Clozapine5-hydroxytryptamine receptor 2Atarget
DB00363Clozapine5-hydroxytryptamine receptor 1Atarget
DB00363Clozapine5-hydroxytryptamine receptor 2Ctarget
DB00363ClozapineD(1A) dopamine receptortarget
DB00363ClozapineCytochrome P450 1A2enzyme
DB00363ClozapineCytochrome P450 2D6enzyme
DB00363ClozapineD(3) dopamine receptortarget
DB00363ClozapineMuscarinic acetylcholine receptor M1target
DB00363ClozapineMuscarinic acetylcholine receptor M2target
DB00363ClozapineMuscarinic acetylcholine receptor M3target
DB00363ClozapineMuscarinic acetylcholine receptor M4target
DB00363ClozapineMuscarinic acetylcholine receptor M5target
DB00363Clozapine5-hydroxytryptamine receptor 1Btarget
DB00363Clozapine5-hydroxytryptamine receptor 1Dtarget
DB00363Clozapine5-hydroxytryptamine receptor 1Etarget
DB00363Clozapine5-hydroxytryptamine receptor 3Atarget
DB00363Clozapine5-hydroxytryptamine receptor 6target
DB00363Clozapine5-hydroxytryptamine receptor 7target
DB00363ClozapineAlpha-1A adrenergic receptortarget
DB00363ClozapineAlpha-1B adrenergic receptortarget
DB00363ClozapineAlpha-2A adrenergic receptortarget
DB00363ClozapineAlpha-2B adrenergic receptortarget
DB00363ClozapineAlpha-2C adrenergic receptortarget
DB00363ClozapineCytochrome P450 2C9enzyme
DB00363ClozapineMultidrug resistance protein 1transporter
DB00363ClozapineCytochrome P450 3A4enzyme
DB00363ClozapineCytochrome P450 2C19enzyme
DB00363ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00363ClozapineUDP-glucuronosyltransferase 1-4enzyme
DB00363ClozapineCytochrome P450 1A1enzyme
DB00363ClozapineCytochrome P450 1B1enzyme
DB00363ClozapineCytochrome P450 2A6enzyme
DB00363ClozapineCytochrome P450 2C8enzyme
DB00363ClozapineCytochrome P450 2E1enzyme
DB00363ClozapineGlutathione S-transferase Ptarget
DB00420PromazineD(2) dopamine receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M4target
DB00420PromazineMuscarinic acetylcholine receptor M2target
DB00420PromazineMuscarinic acetylcholine receptor M3target
DB00420PromazineAlpha-1B adrenergic receptortarget
DB00420PromazineD(1A) dopamine receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M5target
DB00420Promazine5-hydroxytryptamine receptor 2Atarget
DB00420Promazine5-hydroxytryptamine receptor 2Ctarget
DB00420PromazineAlpha-1A adrenergic receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M1target
DB00420PromazineD(4) dopamine receptortarget
DB00420PromazineHistamine H1 receptortarget
DB00420PromazineAlpha-1D adrenergic receptortarget
DB00420PromazineCytochrome P450 2C19enzyme
DB00420PromazineCytochrome P450 1A2enzyme
DB00420PromazineCytochrome P450 3A4enzyme
DB00420PromazineCytochrome P450 2C9enzyme
DB00420PromazineCytochrome P450 2D6enzyme
DB00450DroperidolD(2) dopamine receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineD(2) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineMultidrug resistance protein 1transporter
DB00477ChlorpromazineD(1A) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineD(3) dopamine receptortarget
DB00477ChlorpromazineD(4) dopamine receptortarget
DB00477ChlorpromazineD(1B) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00502HaloperidolD(2) dopamine receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolD(1A) dopamine receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolD(3) dopamine receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolMultidrug resistance protein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 1A1enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinMultidrug resistance protein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB00608ChloroquineTumor necrosis factortarget
DB00608ChloroquineToll-like receptor 9target
DB00608ChloroquineGlutathione S-transferase A2target
DB00608ChloroquineCytochrome P450 2D6enzyme
DB00608ChloroquineCytochrome P450 3A4enzyme
DB00608ChloroquineCytochrome P450 1A1enzyme
DB00608ChloroquineCytochrome P450 2C8enzyme
DB00608ChloroquineCytochrome P450 3A5enzyme
DB00608ChloroquineFe(II)-protoporphyrin IXtarget
DB00608ChloroquineGlutathione S-transferasetarget
DB00608ChloroquineMultidrug resistance protein 1transporter
DB00738PentamidineDNAtarget
DB00738PentamidineCytochrome P450 2C19enzyme
DB00738PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
DB00738PentamidineCytochrome P450 2C8enzyme
DB00738PentamidineCytochrome P450 2D6enzyme
DB00738PentamidineCytochrome P450 1A1enzyme
DB00738PentamidineCytochrome P450 3A5enzyme
DB00738PentamidineCytochrome P450 4A11enzyme
DB00743Gadobenic acidSerum albumincarrier
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00976Telithromycin23S rRNAtarget
DB00976TelithromycinCytochrome P450 3A4enzyme
DB00976TelithromycinCytochrome P450 3A5enzyme
DB00976TelithromycinCytochrome P450 3A7enzyme
DB00976TelithromycinSolute carrier organic anion transporter family member 1B1transporter
DB00976TelithromycinSolute carrier organic anion transporter family member 1B3transporter
DB01087PrimaquineCytochrome P450 1A1enzyme
DB01087PrimaquineCytochrome P450 1A2enzyme
DB01087PrimaquineCytochrome P450 3A4enzyme
DB01087PrimaquineKeratin, type II cytoskeletal 7target
DB01087PrimaquineCytochrome P450 1B1enzyme
DB01087PrimaquineCytochrome P450 2D6enzyme
DB01087PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
DB01087PrimaquineFe(II)-protoporphyrin IXtarget
DB01087PrimaquineMultidrug resistance protein 1transporter
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01155GemifloxacinDNA gyrase subunit Atarget
DB01155GemifloxacinDNA topoisomerase 4 subunit Atarget
DB01155GemifloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB01182PropafenoneSodium channel protein type 5 subunit alphatarget
DB01182PropafenonePotassium voltage-gated channel subfamily H member 2target
DB01182PropafenoneCytochrome P450 1A2enzyme
DB01182PropafenoneCytochrome P450 2D6enzyme
DB01182PropafenoneCytochrome P450 2C8enzyme
DB01182PropafenoneCytochrome P450 3A4enzyme
DB01182PropafenoneMultidrug resistance protein 1transporter
DB01182PropafenoneBeta-1 adrenergic receptortarget
DB01182PropafenoneBeta-2 adrenergic receptortarget
DB01195FlecainideSodium channel protein type 5 subunit alphatarget
DB01195FlecainideCytochrome P450 2D6enzyme
DB01195FlecainideSodium channel protein type 4 subunit alphatarget
DB01195FlecainideCytochrome P450 2C9enzyme
DB01195FlecainidePotassium voltage-gated channel subfamily H member 2target
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 2C19enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinCytochrome P450 3A7enzyme
DB01211ClarithromycinMultidrug resistance protein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinBile salt export pumptransporter
DB01232SaquinavirHuman immunodeficiency virus type 1 proteasetarget
DB01232SaquinavirCytochrome P450 3A4enzyme
DB01232SaquinavirCytochrome P450 3A5enzyme
DB01232SaquinavirAlpha-1-acid glycoprotein 1carrier
DB01232SaquinavirSerum albumincarrier
DB01232SaquinavirCytochrome P450 3A7enzyme
DB01232SaquinavirMultidrug resistance protein 1transporter
DB01232SaquinavirSolute carrier family 22 member 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1A2transporter
DB01232SaquinavirATP-binding cassette sub-family G member 2transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1B1transporter
DB01232SaquinavirMultidrug resistance-associated protein 1transporter
DB01232SaquinavirCanalicular multispecific organic anion transporter 1transporter
DB01232SaquinavirCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01232SaquinavirCytochrome P450 2C8enzyme
DB01232SaquinavirCytochrome P450 2D6enzyme
DB01232SaquinavirSolute carrier organic anion transporter family member 2B1transporter
DB01232SaquinavirBile salt export pumptransporter
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibMultidrug resistance protein 1transporter
DB06589PazopanibATP-binding cassette sub-family G member 2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1-1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB06603PanobinostatCytochrome P450 2D6enzyme
DB06603PanobinostatCytochrome P450 3A4enzyme
DB06603PanobinostatMultidrug resistance protein 1transporter
DB06603PanobinostatHistone deacetylasetarget
DB08865CrizotinibCytochrome P450 3A4enzyme
DB08865CrizotinibCytochrome P450 3A5enzyme
DB08865CrizotinibMultidrug resistance protein 1transporter
DB08865CrizotinibALK tyrosine kinase receptortarget
DB08865CrizotinibHepatocyte growth factor receptortarget
DB08865CrizotinibCytochrome P450 2B6enzyme
DB08865CrizotinibCYP3Aenzyme
DB08903BedaquilineCytochrome P450 3A4enzyme
DB08903BedaquilineATP synthase subunit ctarget
DB09063CeritinibALK tyrosine kinase receptortarget
DB09063CeritinibMultidrug resistance protein 1transporter
DB09063CeritinibCytochrome P450 2C9enzyme
DB09063CeritinibCytochrome P450 3A4enzyme
DB09078LenvatinibVascular endothelial growth factor receptor 1target
DB09078LenvatinibVascular endothelial growth factor receptor 2target
DB09078LenvatinibVascular endothelial growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 1target
DB09078LenvatinibFibroblast growth factor receptor 2target
DB09078LenvatinibFibroblast growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 4target
DB09078LenvatinibPlatelet derived growth factor receptor alphatarget
DB09078LenvatinibRETtarget
DB09078LenvatinibMast/stem cell growth factor receptor Kittarget
DB09078LenvatinibMultidrug resistance protein 1transporter
DB09078LenvatinibATP-binding cassette sub-family G member 2transporter
DB09078LenvatinibCytochrome P450 3A4enzyme
DB09078LenvatinibAldehyde oxidaseenzyme
DB09078LenvatinibCytochrome P450 2C8enzyme
DB09078LenvatinibCytochrome P450 2C9enzyme
DB09078LenvatinibCytochrome P450 1A2enzyme
DB09078LenvatinibCytochrome P450 2B6enzyme
DB09078LenvatinibCytochrome P450 2C19enzyme
DB09078LenvatinibSolute carrier family 22 member 6transporter
DB09078LenvatinibSolute carrier family 22 member 8transporter
DB09078LenvatinibSolute carrier family 22 member 2transporter
DB09078LenvatinibSolute carrier organic anion transporter family member 1B1transporter
DB09078LenvatinibBile salt export pumptransporter
DB09078LenvatinibCytochrome P450 2D6enzyme
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 1-1enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineMultidrug resistance protein 1transporter
DB00458ImipramineSodium-dependent noradrenaline transportertarget
DB00458ImipramineSodium-dependent serotonin transportertarget
DB00458ImipramineCytochrome P450 1A2enzyme
DB00458ImipramineCytochrome P450 2C19enzyme
DB00458ImipramineCytochrome P450 2D6enzyme
DB00458ImipramineHistamine H1 receptortarget
DB00458ImipramineAlpha-1A adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 2Atarget
DB00458ImipramineMuscarinic acetylcholine receptor M1target
DB00458ImipramineMuscarinic acetylcholine receptor M2target
DB00458ImipramineMuscarinic acetylcholine receptor M3target
DB00458ImipramineMuscarinic acetylcholine receptor M4target
DB00458ImipramineMuscarinic acetylcholine receptor M5target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 2target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 3target
DB00458ImipramineAlpha-1D adrenergic receptortarget
DB00458ImipramineAlpha-1-acid glycoprotein 1carrier
DB00458ImipramineSolute carrier family 22 member 2transporter
DB00458ImipramineSolute carrier family 22 member 3transporter
DB00458ImipramineMultidrug resistance protein 1transporter
DB00458ImipramineSolute carrier family 22 member 4transporter
DB00458ImipramineCytochrome P450 3A4enzyme
DB00458ImipramineCytochrome P450 2B6enzyme
DB00458ImipramineCytochrome P450 2C18enzyme
DB00458ImipramineCytochrome P450 2E1enzyme
DB00458ImipramineCytochrome P450 3A7enzyme
DB00458Imipramine5-hydroxytryptamine receptor 2Ctarget
DB00458ImipramineAlpha-1B adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 7target
DB00458ImipramineD(1) dopamine receptortarget
DB00458ImipramineD(2) dopamine receptortarget
DB00458ImipraminePotassium voltage-gated channel subfamily H member 2target
DB00458ImipramineSodium-dependent dopamine transportertarget
DB00458Imipramine5-hydroxytryptamine receptor 1Atarget
DB00458Imipramine5-hydroxytryptamine receptor 6target
DB00458ImipraminePotassium voltage-gated channel subfamily H member 1target
DB00458ImipramineSerum albumincarrier
DB00458ImipramineAlpha-1-acid glycoprotein 2target
DB01242ClomipramineSodium-dependent serotonin transportertarget
DB01242ClomipramineSodium-dependent noradrenaline transportertarget
DB01242ClomipramineGlutathione S-transferase Ptarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Atarget
DB01242ClomipramineCytochrome P450 1A2enzyme
DB01242ClomipramineCytochrome P450 2D6enzyme
DB01242ClomipramineCytochrome P450 2C19enzyme
DB01242ClomipramineMultidrug resistance protein 1transporter
DB01242ClomipramineCytochrome P450 3A4enzyme
DB01242Clomipramine5-hydroxytryptamine receptor 2Btarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Ctarget
DB01242ClomipramineSerum albumincarrier
DB12565AbexinostatHistone deacetylase 1target
DB11830MocetinostatHistone deacetylase 1target
DB11830MocetinostatHistone deacetylase 3target
DB11830MocetinostatHistone deacetylase 2target
DB05223PracinostatHistone deacetylase 1target
DB05223PracinostatHistone deacetylase 2target
DB05223PracinostatHistone deacetylase 3target
DB05223PracinostatHistone deacetylase 6target
DB11637DelamanidDeazaflavin-dependent nitroreductaseenzyme
DB11637DelamanidCytochrome P450 3A4enzyme
DB11637DelamanidSerum albumincarrier
DB11637DelamanidAlpha-1-acid glycoprotein 1carrier
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB06771BesifloxacinCytochrome P450 1A2enzyme
DB00827CinoxacinDNAtarget
DB00827CinoxacinDNA gyrase subunit Atarget
DB00827CinoxacinSolute carrier family 22 member 6transporter
DB00827CinoxacinCytochrome P450 1A2enzyme
DB06160GarenoxacinCytochrome P450 1A2enzyme
DB00978LomefloxacinDNA gyrase subunit Atarget
DB00978LomefloxacinDNA topoisomerase 4 subunit Atarget
DB00978LomefloxacinDNA topoisomerase 2-alphatarget
DB00978LomefloxacinCytochrome P450 1A2enzyme
DB00978LomefloxacinSolute carrier family 22 member 5transporter
DB00978LomefloxacinCanalicular multispecific organic anion transporter 1transporter
DB00779Nalidixic acidDNAtarget
DB00779Nalidixic acidSolute carrier family 22 member 6transporter
DB00779Nalidixic acidTryptophan 2,3-dioxygenaseenzyme
DB06600NemonoxacinCytochrome P450 1A2enzyme
DB13261SitafloxacinCytochrome P450 1A2enzyme
DB05488Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
DB05488Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
DB05488Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
DB01227LevacetylmethadolMu-type opioid receptortarget
DB01227LevacetylmethadolCytochrome P450 3A4enzyme
DB01227LevacetylmethadolNeuronal acetylcholine receptor subunit beta-4target
DB01227LevacetylmethadolNeuronal acetylcholine receptor subunit alpha-3target
DB01227LevacetylmethadolCytochrome P450 3A5enzyme
DB01227LevacetylmethadolCytochrome P450 3A7enzyme
DB01227LevacetylmethadolCytochrome P450 19A1enzyme
DB00391SulpirideD(2) dopamine receptortarget
DB00391SulpirideD(3) dopamine receptortarget
DB00391SulpirideCholinesteraseenzyme
DB00391SulpirideCarbonic anhydrase 2target
DB00391SulpirideCarbonic anhydrase 3target
DB00933MesoridazineD(2) dopamine receptortarget
DB00933Mesoridazine5-hydroxytryptamine receptor 2Atarget
DB00933MesoridazineCytochrome P450 2D6enzyme
DB00526OxaliplatinDNAtarget
DB00526OxaliplatinSolute carrier family 22 member 2transporter
DB00526OxaliplatinHigh affinity copper uptake protein 1transporter
DB00526OxaliplatinSolute carrier family 22 member 3transporter
DB00526OxaliplatinATP-binding cassette sub-family G member 2transporter
DB00526OxaliplatinCytochrome P450 1A1enzyme
DB00526OxaliplatinCytochrome P450 1B1enzyme
DB00526OxaliplatinCytochrome P450 2E1enzyme
DB00526OxaliplatinGlutathione S-transferase theta-1enzyme
DB00526OxaliplatinMetallothionein-1Aenzyme
DB00526OxaliplatinMetallothionein-2enzyme
DB00526OxaliplatinMyeloperoxidaseenzyme
DB00526OxaliplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00526OxaliplatinGlutathione S-transferase Penzyme
DB00526OxaliplatinGlutathione S-transferase Mu 1enzyme
DB00526OxaliplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00526OxaliplatinCanalicular multispecific organic anion transporter 1transporter
DB00526OxaliplatinCopper-transporting ATPase 2transporter
DB00526OxaliplatinCopper-transporting ATPase 1transporter
DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB01599ProbucolATP-binding cassette sub-family A member 1target
DB01599ProbucolLiver carboxylesterase 1target
DB00778Roxithromycin50S ribosomal protein L10target
DB00778RoxithromycinMultidrug resistance protein 1target
DB00778RoxithromycinCytochrome P450 3A4enzyme
DB00778RoxithromycinCytochrome P450 2B6enzyme
DB02638TerlipressinVasopressin V1a receptortarget
DB02638TerlipressinVasopressin V2 receptortarget
DB02638TerlipressinVasopressin V1b receptortarget
DB11640AmifampridineArylamine N-acetyltransferase 1enzyme
DB11640AmifampridineArylamine N-acetyltransferase 2enzyme
DB11640AmifampridinePotassium voltage-gated channel subfamily A member 1target
DB14568IvosidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB14568IvosidenibCytochrome P450 3A4enzyme
DB14568IvosidenibCytochrome P450 2B6enzyme
DB14568IvosidenibCytochrome P450 2C9enzyme
DB14568IvosidenibCytochrome P450 2C8enzyme
DB14568IvosidenibSolute carrier family 22 member 8transporter
DB14568IvosidenibMultidrug resistance protein 1transporter
DB11642PitolisantHistamine H3 receptortarget
DB11642PitolisantCytochrome P450 3A4enzyme
DB11642PitolisantCytochrome P450 2D6enzyme
DB11642PitolisantCytochrome P450 1A2enzyme
DB11642PitolisantCytochrome P450 2B6enzyme
DB11642PitolisantSolute carrier family 22 member 1transporter
DB11642PitolisantPotassium voltage-gated channel subfamily H member 2target
DB01615AceprometazineHistamine H1 receptortarget
DB08799AntazolineHistamine H1 receptortarget
DB01114ChlorphenamineHistamine H1 receptortarget
DB01114ChlorphenamineCytochrome P450 3A4enzyme
DB01114ChlorphenamineCytochrome P450 2D6enzyme
DB01114ChlorphenamineSodium-dependent serotonin transportertarget
DB01114ChlorphenamineSodium-dependent noradrenaline transportertarget
DB01114ChlorphenamineSodium-dependent dopamine transportertarget
DB01114ChlorphenamineCytochrome P450 3A5enzyme
DB01114ChlorphenamineCytochrome P450 3A7enzyme
DB01114ChlorphenamineSolute carrier family 22 member 2transporter
DB01114ChlorphenamineSolute carrier family 22 member 1transporter
DB09016ButriptylineSodium-dependent serotonin transportertarget
DB09016ButriptylineHistamine H1 receptortarget
DB09016Butriptyline5-hydroxytryptamine receptor 2Atarget
DB00748CarbinoxamineHistamine H1 receptortarget
DB00748CarbinoxamineCytochrome P450 2C19enzyme
DB00748CarbinoxamineCytochrome P450 2C8enzyme
DB00748CarbinoxamineCytochrome P450 2E1enzyme
DB00748CarbinoxamineCytochrome P450 3A4enzyme
DB00568CinnarizineHistamine H1 receptortarget
DB00568CinnarizineD(2) dopamine receptortarget
DB00568CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB00568CinnarizineCytochrome P450 2D6enzyme
DB00568CinnarizineCytochrome P450 2B6enzyme
DB00568CinnarizineCytochrome P450 2C9enzyme
DB00568CinnarizineCytochrome P450 1A1enzyme
DB00568CinnarizineCytochrome P450 1A2enzyme
DB00568CinnarizineCytochrome P450 2A6enzyme
DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00568CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00568CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00568CinnarizineD(1) dopamine receptortarget
DB00568CinnarizineMuscarinic acetylcholine receptortarget
DB00568CinnarizineCytochrome P450 3A4enzyme
DB00967DesloratadineHistamine H1 receptortarget
DB00967DesloratadineCytochrome P450 2C9enzyme
DB00967DesloratadineCytochrome P450 2C19enzyme
DB00967DesloratadineCytochrome P450 1A2enzyme
DB00967DesloratadineCytochrome P450 2D6enzyme
DB00967DesloratadineMultidrug resistance protein 1transporter
DB09555Dexchlorpheniramine maleateCytochrome P450 2D6enzyme
DB09555Dexchlorpheniramine maleateHistamine H1 receptortarget
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 1carrier
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 2carrier
DB09555Dexchlorpheniramine maleateCytochrome P450 3A4enzyme
DB00985DimenhydrinateHistamine H1 receptortarget
DB01084EmedastineHistamine H1 receptortarget
DB00950FexofenadineHistamine H1 receptortarget
DB00950FexofenadineMultidrug resistance protein 1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 2B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1A2transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B3transporter
DB00950FexofenadineSolute carrier family 22 member 8transporter
DB00455LoratadineHistamine H1 receptortarget
DB00455LoratadineCytochrome P450 3A4enzyme
DB00455LoratadineCytochrome P450 2C19enzyme
DB00455LoratadineCytochrome P450 2D6enzyme
DB00455LoratadineCytochrome P450 2C8enzyme
DB00455LoratadineMultidrug resistance protein 1transporter
DB00455LoratadinePotassium voltage-gated channel subfamily H member 2target
DB00455LoratadineBile salt export pumptransporter
DB00455LoratadineCytochrome P450 1A1enzyme
DB00455LoratadineCytochrome P450 1A2enzyme
DB00455LoratadineCytochrome P450 2B6enzyme
DB00455LoratadineCytochrome P450 2C9enzyme
DB00455LoratadineCytochrome P450 3A5enzyme
DB00544FluorouracilThymidylate synthasetarget
DB00544FluorouracilCytochrome P450 1A2enzyme
DB00544FluorouracilThymidine phosphorylaseenzyme
DB00544FluorouracilSerum albumincarrier
DB00544FluorouracilCytochrome P450 2C9enzyme
DB00544FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB00544FluorouracilUridine phosphorylase 1enzyme
DB00544FluorouracilUridine phosphorylase 2enzyme
DB00544FluorouracilDNAtarget
DB00544FluorouracilRNAtarget
DB00544FluorouracilCytochrome P450 2A6enzyme
DB00544FluorouracilCytochrome P450 2C8enzyme
DB00544FluorouracilMethylenetetrahydrofolate reductaseenzyme
DB00544FluorouracilThymidylate synthaseenzyme
DB00544FluorouracilUridine 5'-monophosphate synthaseenzyme
DB00544FluorouracilAmidophosphoribosyltransferaseenzyme
DB00544FluorouracilSolute carrier family 22 member 7transporter
DB00544FluorouracilEquilibrative nucleoside transporter 1transporter
DB00544FluorouracilATP-binding cassette sub-family G member 2transporter
DB00544FluorouracilCanalicular multispecific organic anion transporter 2transporter
DB00544FluorouracilMultidrug resistance-associated protein 4transporter
DB00544FluorouracilMultidrug resistance-associated protein 5transporter
DB00544FluorouracilThyroxine-binding globulincarrier
DB01193AcebutololBeta-1 adrenergic receptortarget
DB01193AcebutololCytochrome P450 2D6enzyme
DB01193AcebutololBeta-2 adrenergic receptortarget
DB01193AcebutololMultidrug resistance protein 1transporter
DB00640AdenosineAdenosine receptor A3target
DB00640AdenosineAdenosine deaminaseenzyme
DB00640AdenosineAdenosine kinaseenzyme
DB00640AdenosineAdenosine receptor A1target
DB00640AdenosineAdenosine receptor A2atarget
DB00640AdenosineAdenosine receptor A2btarget
DB00640AdenosineSolute carrier family 28 member 3transporter
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB04957AzimilidePotassium voltage-gated channel subfamily E member 1target
DB04957AzimilidePotassium voltage-gated channel subfamily KQT member 1target
DB04957AzimilidePotassium voltage-gated channel subfamily H member 2target
DB04957AzimilideCytochrome P450 1A1enzyme
DB04957AzimilideCytochrome P450 3A4enzyme
DB04957AzimilideCytochrome P450 3A5enzyme
DB09231BenidipineVoltage-dependent L-type calcium channeltarget
DB09231BenidipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB09231BenidipineVoltage-dependent T-type calcium channeltarget
DB09231BenidipineCytochrome P450 3A4enzyme
DB09231BenidipineCytochrome P450 3A5enzyme
DB00612BisoprololBeta-1 adrenergic receptortarget
DB00612BisoprololBeta-2 adrenergic receptortarget
DB00612BisoprololCytochrome P450 2D6enzyme
DB00612BisoprololCytochrome P450 3A4enzyme
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB14063DexverapamilMultidrug resistance protein 1target
DB14063DexverapamilCytochrome P450 3A4enzyme
DB00343DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DB00343DiltiazemCytochrome P450 3A4enzyme
DB00343DiltiazemCytochrome P450 2C19enzyme
DB00343DiltiazemCytochrome P450 2D6enzyme
DB00343DiltiazemCytochrome P450 3A5enzyme
DB00343DiltiazemCytochrome P450 3A7enzyme
DB00343DiltiazemMultidrug resistance protein 1transporter
DB00343DiltiazemCytochrome P450 2C8enzyme
DB00343DiltiazemSerum albumincarrier
DB00343DiltiazemAlpha-1-acid glycoprotein 1carrier
DB00343DiltiazemVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB08992EperisoneCytochrome P450 3A4enzyme
DB08980FendilineCytochrome P450 3A4enzyme
DB04842FluspirileneD(2) dopamine receptortarget
DB04842Fluspirilene5-hydroxytryptamine receptor 2Atarget
DB04842FluspirileneVoltage-dependent calcium channel gamma-1 subunittarget
DB04842FluspirileneCytochrome P450 3A4enzyme
DB08952IndenololCytochrome P450 2D6enzyme
DB00922LevosimendanTroponin C, slow skeletal and cardiac musclestarget
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 11target
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 8target
DB00922LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00836LoperamideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00836LoperamideMu-type opioid receptortarget
DB00836LoperamideCalmodulintarget
DB00836LoperamidePro-opiomelanocortintarget
DB00836LoperamideDelta-type opioid receptortarget
DB00836LoperamideCytochrome P450 3A4enzyme
DB00836LoperamideMultidrug resistance protein 1transporter
DB00836LoperamideKappa-type opioid receptortarget
DB00836LoperamideCytochrome P450 2C8enzyme
DB00836LoperamideCytochrome P450 2B6enzyme
DB00836LoperamideCytochrome P450 2D6enzyme
DB00836LoperamideNuclear receptor subfamily 1 group I member 3target
DB09224MelperoneD(2) dopamine receptortarget
DB09224MelperoneCytochrome P450 2D6enzyme
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
DB01388MibefradilCytochrome P450 3A4enzyme
DB01388MibefradilCytochrome P450 1A2enzyme
DB01388MibefradilCytochrome P450 2D6enzyme
DB01388MibefradilCytochrome P450 3A5enzyme
DB01388MibefradilCytochrome P450 3A7enzyme
DB01388MibefradilMultidrug resistance protein 1transporter
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
DB01388MibefradilCytochrome P450 11B1, mitochondrialenzyme
DB01388MibefradilCytochrome P450 11B2, mitochondrialenzyme
DB01388MibefradilCytochrome P450 1A1enzyme
DB01115NifedipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB01115NifedipineCytochrome P450 3A4enzyme
DB01115NifedipineCytochrome P450 2E1enzyme
DB01115NifedipineCytochrome P450 2D6enzyme
DB01115NifedipineCalmodulintarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01115NifedipinePotassium voltage-gated channel subfamily A member 1target
DB01115NifedipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01115NifedipineCytochrome P450 1A2enzyme
DB01115NifedipineCytochrome P450 2A6enzyme
DB01115NifedipineCytochrome P450 2C8enzyme
DB01115NifedipineCytochrome P450 3A5enzyme
DB01115NifedipineCytochrome P450 3A7enzyme
DB01115NifedipineCanalicular multispecific organic anion transporter 2transporter
DB01115NifedipineMultidrug resistance protein 1transporter
DB01115NifedipineCanalicular multispecific organic anion transporter 1transporter
DB01115NifedipineCytochrome P450 1A1enzyme
DB01115NifedipineCytochrome P450 2B6enzyme
DB01115NifedipineNuclear receptor subfamily 1 group I member 2target
DB01115NifedipineSolute carrier organic anion transporter family member 1B1transporter
DB01115NifedipineBile salt export pumptransporter
DB06712NilvadipineCytochrome P450 3A4enzyme
DB06712NilvadipineCytochrome P450 2A6enzyme
DB06712NilvadipineCytochrome P450 2C19enzyme
DB06712NilvadipineCytochrome P450 2C8enzyme
DB06712NilvadipineCytochrome P450 2E1enzyme
DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB06712NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB06712NilvadipineVoltage-dependent L-type calcium channel subunit beta-2target
DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB06712NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00393NimodipineCytochrome P450 3A4enzyme
DB00393NimodipineMineralocorticoid receptortarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-3target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-4target
DB00393NimodipineCytochrome P450 3A5enzyme
DB00393NimodipineAryl hydrocarbon receptortarget
DB13500OtiloniumCytochrome P450 3A4enzyme
DB01580OxprenololBeta-1 adrenergic receptortarget
DB01580OxprenololBeta-2 adrenergic receptortarget
DB01580OxprenololSolute carrier family 22 member 2transporter
DB01580OxprenololCytochrome P450 2D6enzyme
DB01580OxprenololBeta-3 adrenergic receptortarget
DB13791PenfluridolCytochrome P450 3A4enzyme
DB04825PrenylamineCalmodulintarget
DB04825PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB04825PrenylamineCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzSerum albumincarrier
DB00625EfavirenzCytochrome P450 3A5enzyme
DB00625EfavirenzCytochrome P450 3A7enzyme
DB00625EfavirenzUDP-glucuronosyltransferase 1-1enzyme
DB00625EfavirenzBile salt export pumptransporter
DB00625EfavirenzSolute carrier family 22 member 1transporter
DB12141GilteritinibSerum albumincarrier
DB12141GilteritinibCytochrome P450 3A4enzyme
DB12141GilteritinibReceptor-type tyrosine-protein kinase FLT3target
DB12141GilteritinibSerotonin Receptorstarget
DB12141GilteritinibMultidrug resistance protein 1transporter
DB12141GilteritinibMultidrug and toxin extrusion protein 1transporter
DB12141GilteritinibATP-binding cassette sub-family G member 2transporter
DB12141GilteritinibSolute carrier family 22 member 1transporter
DB12141GilteritinibTyrosine-protein kinase receptor UFOtarget
DB12141GilteritinibALK tyrosine kinase receptortarget
DB00433ProchlorperazineD(2) dopamine receptortarget
DB00433ProchlorperazineCytochrome P450 2D6enzyme
DB00433ProchlorperazineCytochrome P450 3A4enzyme
DB04948LofexidineAlpha-2A adrenergic receptortarget
DB04948LofexidineAlpha-1A adrenergic receptortarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Atarget
DB04948Lofexidine5-hydroxytryptamine receptor 7target
DB04948Lofexidine5-hydroxytryptamine receptor 2Ctarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Dtarget
DB04948LofexidineCytochrome P450 2D6enzyme
DB04948LofexidineCytochrome P450 1A2enzyme
DB04948LofexidineCytochrome P450 2C19enzyme
DB04948LofexidineATP-binding cassette sub-family B member 5transporter
DB04948LofexidineMultidrug and toxin extrusion protein 1transporter
DB00243RanolazineCytochrome P450 3A4enzyme
DB00243RanolazineCytochrome P450 2D6enzyme
DB00243RanolazineBile salt export pumptransporter
DB00243RanolazineMultidrug resistance protein 1transporter
DB00243RanolazineSerum albumincarrier
DB00243RanolazineVoltage gated sodium channeltarget
DB00243RanolazineInward rectifier potassium channeltarget
DB00243RanolazineVoltage-dependent L-type calcium channeltarget
DB00243RanolazineAlpha-1 adrenergic receptorstarget
DB00243RanolazineBeta-1 adrenergic receptortarget
DB00243RanolazineFatty acidtarget
DB00243RanolazineAlpha-1-acid glycoprotein 1carrier