Osmotic Laxatives

DrugDrug NameDrug Indication
DB09472Sodium sulfateindicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
DB09481Magnesium carbonateUsed as an over the counter antacid [L593].
DB11110Magnesium citrateMagnesium citrate has been used in bowel preparations prior to a colonoscopy as a cathartic agent.[T215] It is also used in over-the-counter products to relieve occasional constipation.[L2841] Magnesium citrate can be one of the forms used for the administration of dietary supplements.[L2842]
DB12942LactitolNot Available
DB00581LactuloseLactulose is indicated for use as a laxative in the treatment of chronic constipation in adults and geriatric patients.[FDA Label,L6199,L6202] Additionally, lactulose is also employed as an adjunct to protein restriction and supportive therapy for the prevention and treatment of portal-systemic encephalopathy (PSE), including both the hepatic pre-coma and coma variations.[FDA Label,L6199,L6202] In particular, lactulose solution has been effective at managing PSE resulting from surgical portacaval shunts or from chronic hepatic diseases like cirrhosis.[L6199] Moreover, there have also been studies demonstrating the capacity for lactulose to minimize the formation of gallstones and even some investigations regarding the experimental use of the agent in developing novel anticancer agents owing to its ability to bind galactin carbohydrates involved in various tumor progressions [L6202].
DB00653Magnesium sulfateUsed for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
DB09287Polyethylene glycolUsed to treat and prevent constipation.
DB00742MannitolUsed for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
DB01377Magnesium oxideIndicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach.
DB01638SorbitolUsed as a non-stimulant laxative via an oral suspension or enema.
DB09449Sodium phosphate, monobasicUsed to treat constipation or to clean the bowel before a colonoscopy [FDA Label].
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB11089DocusateIndicated for the treatment of constipation associated with dry, hard stools or opioid induced constipation[A176984]. Though recently, pressure has been building to end the use of docusate over concerns of efficacy[A176972,A176987,L5912].
DB13486Magnesium peroxideNot Available
DB13526PentaerithritylNot Available
DB13707Sodium tartrate It acts as an emulsifier and pH control agent in food products [L2590], [L2598]. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances [F18], [L2590].
DB09104Magnesium hydroxideMagnesium hydroxide can be used as an antacid or a laxative depending on the administered dose. As an antacid, it is used for the temporary relief of heartburn, upset stomach, sour stomach or acid indigestion. As a laxative, it is used for the relief of occasional constipation by promoting bowel movements for 30 minutes and up to 6 hours.
DB01378Magnesium cationNot Available
DB14516Sodium cationNot Available
DB14546Sulfate ionNot Available
DB09269Phenylacetic acidFor use as adjunctive therapy for the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle.
DB09281Magnesium trisilicateFor the treatment of peptic ulcers. Relieving indigestion and heartburn.
DB09409Magnesium acetate tetrahydrateUsed as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention [T28]. Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.
DB09413Monopotassium phosphateUsed in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;
DB09414Dipotassium phosphateDipotassium phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.
DB09484Sodium fluorophosphateSodium monofluorophosphate is indicated for the treatment of cavities
DB11189Magnesium glycinateNot Available
DB13180Gluconic AcidFor use as part of electrolyte supplementation in total parenteral nutrition [FDA Label].
DB13743Sodium aurotiosulfateNot Available
DB13996Magnesium acetateNot Available
DB14482Sodium ascorbateNot Available
DB14499Potassium sulfatePotassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.
DB14502Sodium phosphate, dibasicUsed to treat constipation or to clean the bowel before a colonoscopy [FDA Label].
DB14503Sodium phosphate, monobasic, unspecified formUsed to treat constipation or to clean the bowel before a colonoscopy [FDA Label].
DB14504Sodium phosphate, dibasic, unspecified formNot Available
DB14513MagnesiumNot Available
DrugDrug NameTargetType
DB09472Sodium sulfateCarbonic anhydrase 2target
DB09472Sodium sulfateCarbonic anhydrase 1target
DB09481Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
DB09481Magnesium carbonateSolute carrier family 41 member 3transporter
DB09481Magnesium carbonateMetal transporter CNNM2transporter
DB09481Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
DB09481Magnesium carbonateGlutamate (NMDA) receptortarget
DB00581LactuloseEvolved beta-galactosidase subunit alphatarget
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00742MannitolMultidrug resistance protein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transporter 1transporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transporter 2transporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Atransporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Btransporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Ctransporter
DB09462GlycerinHematopoietic prostaglandin D synthasetarget
DB09462GlycerinEndoglucanase Gtarget
DB09462GlycerinGlutathione S-transferase Ptarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinCytochrome c4target
DB09462GlycerinBacterioferritintarget
DB09462GlycerinTGF-beta receptor type-2target
DB09462GlycerinArgininosuccinate synthasetarget
DB09462GlycerinEnolasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinMultidrug resistance protein MexAtarget
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinHistidinol dehydrogenasetarget
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinGlycerol uptake facilitator proteintarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB01378Magnesium cationSodium/potassium-transporting ATPase subunit alpha-1target
DB09269Phenylacetic acidLiver carboxylesterase 1enzyme
DB09409Magnesium acetate tetrahydrateGlutamate (NMDA) receptortarget
DB09413Monopotassium phosphateIntestinal-type alkaline phosphataseenzyme
DB09414Dipotassium phosphate3-oxoacyl-[acyl-carrier-protein] synthase 2enzyme
DB13996Magnesium acetateSodium/potassium-transporting ATPase subunit alpha-1target
DB14499Potassium sulfateSodium/potassium-transporting ATPase subunit alpha-1target
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transporter 1transporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transporter 2transporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Atransporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Btransporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Ctransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 1transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 2transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Atransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Btransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Ctransporter