Aloe Vera Leaf


Aloe Vera Leaf
Accession Number
Approved, Experimental
Biologic Classification
Protein Based Therapies
Other protein based therapies

Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or Aloe barbadensis miller, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated 4. The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties 5. Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose 3. Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation 2.

Protein chemical formula
Not Available
Protein average weight
Not Available
Not Available
  • Aloe
  • Aloe (aloe barbadensis)
  • Aloe barbadensis leaf
  • Aloe barbadensis leaf extract
  • Aloe barbadensis leaf juice
  • Aloe barbadensis leaf juice powder
  • Aloe barbadensis leaf powder
  • Aloe barbadensis leaf water
  • Aloe folii extractus (aloe vera)
  • Aloe folium (aloe vera)
  • Aloe herba (aloe vera)
  • Aloe leaf extract
  • Aloe vera
  • Aloe vera dry leaf juice
  • Aloe vera extract
  • Aloe vera leaf extract
  • Aloe vera leaf exudate
  • Aloe vera leaf juice
  • Aloe vera leaf mucilage
  • Aloe vera leaf powder
  • Aloe vera mucilage
  • Aloes
  • Aloes (aloe barbadensis)
  • Barbatos aloe leaf
  • Curacao aloe leaf
  • Ghrita kumari leaf
  • Kanyasara
  • Lu hui (aloe vera)
  • Lu hui ye
  • Luhui (aloe barbadensis)
External IDs
Fema no. 2047
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aloe Vera GelGel5 g/100gTopicalYuyao Jessie Commodity Co.,Ltd.2014-05-08Not applicableUs
Ato Stop SiseundeusiCream46.27 g/100gTopicalGk Cosmetic Co., Ltd.2016-11-18Not applicableUs
Ato Stop SiseundeusiLotion63.52 g/100gTopicalGk Cosmetic Co., Ltd.2016-11-18Not applicableUs
Bring Green Fresh Mask AloePatch10.0 g/20gTopicalCj Olive Networks Co., Ltd.2018-05-01Not applicableUs
Capsulax Cap 250mgCapsuleOralProduits Aloex Ltee1992-12-311997-09-11Canada
Capsulax Capsules 250mgCapsuleOralSantrel International Inc.1992-12-312000-09-11Canada
HelloMouthwash20 g/100mLDentalHello International2018-06-01Not applicableUs
Lafiya personal lubricant X002CRXC1TOil4.74 g/237mLVaginalDongguanshi Chunzhen Biotechnology Co.,Ltd2019-12-01Not applicableUs
Ramosu Aloe Vera Leaf Extract 100Liquid100 g/100mLTopicalRaMoSu2016-02-04Not applicableUs
Secret No 1Stick2.62 g/35gTopicalKj Trading, Jk Global(trade)2016-07-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Aloe Vera SprayerAloe Vera Leaf (2 g/100g) + Glycerin (4 g/100g) + Propylene glycol (2 g/100g) + Tocopherol (0.5 g/100g)LiquidTopicalNINGBO JIANGBEI OCEAN STAR TRADING CO.,LTD2015-02-20Not applicableUs
AtopimAloe Vera Leaf (64 g/100g) + Glycerin (2.5 g/100g)LiquidTopicalHI Technology2019-05-11Not applicableUs
BenzoinAloe Vera Leaf (.12 g/0.6mL) + Benzoin (0.6 g/0.6mL) + Liquidambar styraciflua resin (.48 g/0.6mL) + Tolu balsam (.24 g/0.6mL)SwabTopicalJames Alexander Corporation1976-10-25Not applicableUs
Bicholate LilasAloe Vera Leaf (12 mg) + Bisacodyl (5 mg) + Frangula purshiana bark (30 mg) + Sodium taurocholate (60 mg)TabletOralSabex Inc1998-10-282009-11-24Canada
C Ottways Lax TabAloe Vera Leaf (132 mg) + Capsicum (19 mg) + Frangula purshiana bark (28 mg) + Ginger (9 mg) + Glycyrrhiza glabra (28 mg) + Sennosides (28 mg)TabletOralC Ottway Herbalist1950-12-311997-06-13Canada
Eczema TherapyAloe Vera Leaf (0.12 g/100g) + Chamomile (0.3 g/100g) + Tea tree oil (0.2 g/100g)SoapTopicalGolden B America, Llc.2018-03-13Not applicableUs
HerbalaxAloe Vera Leaf (120 mg) + Rhubarb (150 mg)CapsuleOralEnzymatic Therapy, Inc.1997-03-202001-07-31Canada
Iris Hand Sanitizing WipesAloe Vera Leaf (.01 g/100g) + Ethanol (62 g/100g) + alpha-Tocopherol acetate (.01 g/100g)ClothTopicalAMERIFOODS TRADING COMPANY2016-01-31Not applicableUs
Lax-easeAloe Vera Leaf (50 mg) + Frangula purshiana bark (120 mg) + Rhubarb (80 mg) + Sennosides (50 mg)CapsuleOralPuresource Inc.Not applicableNot applicableCanada
LaxativeAloe Vera Leaf (60 mg) + Frangula purshiana bark (100 mg) + Sodium taurocholate (60 mg)TabletOralLaboratoire Lalco Inc.1998-06-052006-09-07Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Alcortin AAloe Vera Leaf (10 mg/1g) + Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalPrimus Pharmaceuticals2010-01-01Not applicableUs
Alcortin AAloe Vera Leaf (10 mg/1g) + Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalNovum Pharma, Llc2015-03-01Not applicableUs
AloquinAloe Vera Leaf (10 mg/1g) + Diiodohydroxyquinoline (12.5 mg/1g)GelTopicalPrimus Pharmaceuticals2009-07-06Not applicableUs
AloquinAloe Vera Leaf (10 mg/1g) + Diiodohydroxyquinoline (12.5 mg/1g)GelTopicalNovum Pharma, Llc2015-03-01Not applicableUs
Ato Stop SiseundeusiAloe Vera Leaf (46.27 g/100g)CreamTopicalGk Cosmetic Co., Ltd.2016-11-18Not applicableUs
Ato Stop SiseundeusiAloe Vera Leaf (63.52 g/100g)LotionTopicalGk Cosmetic Co., Ltd.2016-11-18Not applicableUs
BenzoinAloe Vera Leaf (.12 g/0.6mL) + Benzoin (0.6 g/0.6mL) + Liquidambar styraciflua resin (.48 g/0.6mL) + Tolu balsam (.24 g/0.6mL)SwabTopicalJames Alexander Corporation1976-10-25Not applicableUs
Bring Green Fresh Mask AloeAloe Vera Leaf (10.0 g/20g)PatchTopicalCj Olive Networks Co., Ltd.2018-05-01Not applicableUs
Eczema TherapyAloe Vera Leaf (0.12 g/100g) + Chamomile (0.3 g/100g) + Tea tree oil (0.2 g/100g)SoapTopicalGolden B America, Llc.2018-03-13Not applicableUs
Iodoquinol Hydrocortisone Acetate Aloe PolysaccharidesAloe Vera Leaf (10 mg/1g) + Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalSyntenza Pharmaceuticals Llc2018-11-01Not applicableUs
Not Available
CAS number



Indicated for use as a topical agent to soothe sensitive skin and to relieve symptoms of various skin conditions, including contact or atopic dermatitis, eczema, dermatitis and acne urticata, first- and second-degree burns, radiation dermatitis, and sunburn.

Associated Conditions

Aloe polysaccharides mediate antioxidant and anti-inflammatory actions, as well as immunoregulatory activities. Various studies indicate that aloe polysaccharides possess effective free radical scavenging activity in vitro, and produce potent antioxidant potential during oxidative stress in vivo 4. According to the findings of studies in vitro and in vivo, aloe polysaccharides exhibit radioprotective activity. Treatment with acemmanan, which is a common aloe polysaccharide, on CH3 mice with radiation-induced skin reactions resulted in reduced signs of those reactions 2. Studies suggest that aloe polysaccharides may evidently attenuate tumor growth in mice 2. Treatment of aloe polysaccharides in Vero cells as well as in the in vivo zebrafish model led to protective effects against AAPH-indued oxidative stress resulting from accumulation of free radical species and improved cell viability 1.

Mechanism of action

It is suggested that aloe polysaccharides mediate skin-protectant effects in damaged skin, induced by internal or other external factors such as radiation, via inhibiting apoptosis of normal cell lines in vitro and thrombocytes in vivo 2. Following irradiation, aloe polysaccharides block the upregulation of pro-apoptotic p53, Bax, and Bad while blocking downregulating anti-apoptotic Bcl-2 2. In vivo, aloe polysaccharides may act as a scavenger for oxygen free radicals including DPPH, alkyl radicals, superoxides, and singlet oxygen and hydroxyl radicals that may also be generated by superoxides 1,4. Hydrogen peroxide, which is a weak initiate lipid peroxidation, may also be effectively scavenged by aloe polysaccharides 4. In a Fenton reaction system, aloe polysaccharides demonstrated a concentration-dependent scavenging activity against hydroxyl radical that were generated during the reaction 4. Aloe polysaccharides may also compete with oxygen to react with nitric oxide (NO), thereby inhibiting the generation of nitrite and peroxynitrite anions that act as free radicals 4.

Findings from a study investigating the effects of aloe polysaccharides on doxorubicin-induced oxidative stress suggest that aloe polysaccharides mediate potent antioxidant actions in vivo 4. Doxorubicin, known to generate reactive oxygen species such as superoxide and hydroxy radicals, was administered to albino rats. This led to myocardial oxidative stress and cardiac injury accompanied by leakage of LDH and CPK from cardiac myocytes and to serum due to lipid peroxidation of cardiac membranes, reduced levels of antioxidant coenzyme GSH, and increased levels of SOD from a compensatory and combative mechanism of oxidative stress 4. Treatment with aloe polysaccharides resulted in a significant decrease in serum LDH and CPK levels, indicating that aloe polysaccharides are capable in stabilizing cardiac membranes from peroxidative damage. Restored levels of endogenous GSH and SOD in a dose-dependent manner were also observed with the treatment of aloe polysaccharides, suggesting that aloe polysaccharides exhibit potent antioxidant properties 4.

In a study of rats with open cutaneous back wounds, treatment with aloe polysaccharides decreased the levels of matrix metalloproteinase-3 (MMP-3) and induced tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) during the early stage of wound repair, resulting in decreased collagen breakdown and increased preservation of collagen content in the injured area 6. A study proposes that acemannan, a common aloe polysaccharide, stimulates BMSC proliferation, ALPase activity, expression of VEGF, BMP-2, OPN, BSP, and mineralization leading to osteoblast differentiation and bone formation during socket healing 3.

AFree radicals
Additional Data Available
Adverse Effects

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Additional Data Available

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Blackbox Warnings

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No pharmacokinetic data available.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.


No pharmacokinetic data available.

Route of elimination

No pharmacokinetic data available.

Half life

No pharmacokinetic data available.


No pharmacokinetic data available.


The oral LD50 value of aloe polysaccharides in a mouse toxicity study was 6.1 g/kg 4. No cases of overdose reported.

Affected organisms
Not Available
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available


General References
  1. Kang MC, Kim SY, Kim YT, Kim EA, Lee SH, Ko SC, Wijesinghe WA, Samarakoon KW, Kim YS, Cho JH, Jang HS, Jeon YJ: In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel. Carbohydr Polym. 2014 Jan;99:365-71. doi: 10.1016/j.carbpol.2013.07.091. Epub 2013 Aug 31. [PubMed:24274519]
  2. Wang ZW, Zhou JM, Huang ZS, Yang AP, Liu ZC, Xia YF, Zeng YX, Zhu XF: Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis. J Radiat Res. 2004 Sep;45(3):447-54. [PubMed:15613791]
  3. Boonyagul S, Banlunara W, Sangvanich P, Thunyakitpisal P: Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model. Odontology. 2014 Jul;102(2):310-7. doi: 10.1007/s10266-012-0101-2. Epub 2013 Jan 12. [PubMed:23315202]
  4. Kaithwas G, Singh P, Bhatia D: Evaluation of in vitro and in vivo antioxidant potential of polysaccharides from Aloe vera (Aloe barbadensis Miller) gel. Drug Chem Toxicol. 2014 Apr;37(2):135-43. doi: 10.3109/01480545.2013.834350. Epub 2014 Feb 13. [PubMed:24524259]
  5. Surjushe A, Vasani R, Saple DG: Aloe vera: a short review. Indian J Dermatol. 2008;53(4):163-6. doi: 10.4103/0019-5154.44785. [PubMed:19882025]
  6. Tabandeh MR, Oryan A, Mohammadalipour A: Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. Int J Biol Macromol. 2014 Apr;65:424-30. doi: 10.1016/j.ijbiomac.2014.01.055. Epub 2014 Jan 31. [PubMed:24491493]
External Links
PubChem Substance

Clinical Trials

Clinical Trials
1, 2Enrolling by InvitationPreventionBreath odour1
2CompletedSupportive CareOral Mucositis1
2RecruitingPreventionDental Decay1
2, 3CompletedTreatmentPeriodontal Diseases1
2, 3CompletedTreatmentPeriodontitis1
2, 3CompletedTreatmentPeriodontitis, Chronic2
4CompletedPreventionOral Ulcers1
4CompletedTreatmentDiabetes Mellitus / Periodontitis, Chronic1
Not AvailableCompletedPreventionOral Health1
Not AvailableCompletedTreatmentExercise-induced Aseptic Inflammation / Performance / Skeletal Muscle Damage1


Not Available
Not Available
Dosage forms
GelTopical5 g/100g
LiquidOral99.5 g/100mL
CreamTopical46.27 g/100g
LotionTopical63.52 g/100g
PatchTopical10.0 g/20g
MouthwashDental20 g/100mL
OilVaginal4.74 g/237mL
LiquidTopical100 g/100mL
StickTopical2.62 g/35g
Not Available
Not Available


Experimental Properties
Not Available


Not Available
Organic Compounds
Super Class
Organic Acids
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Alternative Parents
Not Available
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available


1. Free radicals
Pharmacological action
  1. Kaithwas G, Singh P, Bhatia D: Evaluation of in vitro and in vivo antioxidant potential of polysaccharides from Aloe vera (Aloe barbadensis Miller) gel. Drug Chem Toxicol. 2014 Apr;37(2):135-43. doi: 10.3109/01480545.2013.834350. Epub 2014 Feb 13. [PubMed:24524259]

Drug created on September 08, 2017 14:22 / Updated on March 01, 2020 21:42

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