Psoriasis

Also known as: PSORIASIS / Psoriasis unspecified / Psoriasis, unspecified

DrugDrug NameDrug Description
DB00993AzathioprineAn immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis.
DB11082Coal tarCoal tar is a brown or black liquid of extremely high viscosity. Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas. Coal tars are complex and variable mixtures of phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds. It has been indicated for local relief of itching, dryness, and irritation caused by psoriasis, seborrhea and eczema.
DB00091CyclosporineA cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).
DB01024Mycophenolic acidMycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).
DB00936Salicylic acidA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
DB00864TacrolimusTacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
DrugDrug NameTargetType
DB00993AzathioprineHypoxanthine-guanine phosphoribosyltransferasetarget
DB00993AzathioprineThiopurine S-methyltransferaseenzyme
DB00993AzathioprineXanthine dehydrogenase/oxidaseenzyme
DB00993AzathioprineGlutathione S-transferase A1enzyme
DB00993AzathioprineGlutathione S-transferase A2enzyme
DB00993AzathioprineGlutathione S-transferase Mu 1enzyme
DB00993AzathioprineRas-related C3 botulinum toxin substrate 1target
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineCytochrome P450 3A7enzyme
DB00091CyclosporineMultidrug resistance protein 1transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 2transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineMultidrug resistance-associated protein 1transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1A2transporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2C8enzyme
DB00091CyclosporineCytochrome P450 2C9enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 2target
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 1target
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-1enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-9enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 2B7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-6enzyme
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMultidrug resistance protein 1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusCytochrome P450 3A7enzyme
DB00864TacrolimusMultidrug resistance protein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DrugDrug NamePhaseStatusCount
DB01048Abacavir1Completed1
DB12187Abacavir hydroxyacetate1Completed1
DB00051Adalimumab1Completed1
DB08878Aminopterin1Completed1
DB00443Betamethasone1Completed4
DB11776Brodalumab1Completed3
DB00201Caffeine1Completed2
DB02300Calcipotriol1Completed1
DB02300Calcipotriol1Recruiting2
DB00136Calcitriol1Completed1
DB01013Clobetasol propionate1Completed1
DB01013Clobetasol propionate1Terminated1
DB05219Crisaborole1Completed1
DB00514Dextromethorphan1Completed1
DB00005Etanercept1Completed1
DB00977Ethinyl Estradiol1Recruiting1
DB00927Famotidine1Completed2
DB12344Fezakinumab1Completed1
DB12356Fletikumab1Terminated1
DB11834Guselkumab1Completed2
DB11737Icotinib1Completed1
DB11737Icotinib1Recruiting1
DB11569Ixekizumab1Active Not Recruiting1
DB11569Ixekizumab1Recruiting1
DB13029MK-08731Completed1
DB00563Methotrexate1Completed1
DB00563Methotrexate1Recruiting1
DB00264Metoprolol1Completed1
DB00683Midazolam1Completed2
DB00683Midazolam1Not Yet Recruiting1
DB00717Norethisterone1Recruiting1
DB00338Omeprazole1Completed2
DB06589Pazopanib1Completed1
DB11786Pefcalcitol1Completed1
DB09029Secukinumab1Completed1
DB00864Tacrolimus1Completed1
DB00799Tazarotene1Completed1
DB08895Tofacitinib1Completed1
DB00596Ulobetasol1Completed1
DB05679Ustekinumab1Completed2
DB00682Warfarin1Completed2
DB09145Water1Completed1
DB00051Adalimumab1 / 2Terminated1
DB00443Betamethasone1 / 2Completed3
DB02300Calcipotriol1 / 2Completed4
DB00115Cyanocobalamin1 / 2Terminated1
DB00091Cyclosporine1 / 2Completed2
DB00111Daclizumab1 / 2Completed2
DB00095Efalizumab1 / 2Completed1
DB00005Etanercept1 / 2Completed1
DB00158Folic Acid1 / 2Terminated1
DB00563Methotrexate1 / 2Completed1
DB00165Pyridoxine1 / 2Terminated1
DB030441-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea2Completed1
DB01281Abatacept2Active Not Recruiting1
DB00459Acitretin2Completed1
DB00051Adalimumab2Completed5
DB00240Alclometasone2Completed1
DB00092Alefacept2Completed2
DB00523Alitretinoin2Completed1
DB05676Apremilast2Completed4
DB05676Apremilast2Recruiting1
DB01076Atorvastatin2Completed1
DB12696BMS-5829492Completed1
DB11817Baricitinib2Completed1
DB09323Benzathine benzylpenicillin2Terminated1
DB11776Brodalumab2Completed1
DB11776Brodalumab2Terminated1
DB05024CTA0182Completed1
DB00136Calcitriol2Completed1
DB08904Certolizumab pegol2Completed1
DB11121Chloroxylenol2Completed1
DB00169Cholecalciferol2Completed1
DB05219Crisaborole2Completed3
DB01003Cromoglicic acid2Completed1
DB00091Cyclosporine2Withdrawn1
DB00530Erlotinib2Withdrawn1
DB00005Etanercept2Completed1
DB12213Etaracizumab2Completed1
DB01073Fludarabine2Completed1
DB00623Fluphenazine2Completed1
DB00623Fluphenazine2Terminated1
DB01120Gliclazide2Completed1
DB11834Guselkumab2Completed1
DB00065Infliximab2Completed2
DB11569Ixekizumab2Active Not Recruiting1
DB06655Liraglutide2Recruiting1
DB05512MM-0932Completed1
DB11711Navarixin2Completed1
DB11786Pefcalcitol2Not Yet Recruiting1
DB11708Peficitinib2Completed1
DB01132Pioglitazone2Unknown Status1
DB12016Ponesimod2Completed1
DB00140Riboflavin2Recruiting1
DB11182Rose bengal2Active Not Recruiting1
DB11182Rose bengal2Completed2
DB12186SRT-21042Completed1
DB09029Secukinumab2Recruiting2
DB01261Sitagliptin2Completed2
DB09153Sodium Chloride2Completed1
DB05681Talarozole2Completed2
DB13083Talarozole2Completed2
DB00799Tazarotene2Completed1
DB05088Tiomolibdate ion2Completed1
DB08895Tofacitinib2Completed2
DB12522Toreforant2Completed1
DB00596Ulobetasol2Completed2
DB05679Ustekinumab2Active Not Recruiting1
DB05679Ustekinumab2Completed2
DB05507VX-7652Completed1
DB09145Water2Completed1
DB10318Zoster vaccine2Active Not Recruiting1
DB10318Zoster vaccine2Recruiting1
DB00051Adalimumab2 / 3Completed1
DB00051Adalimumab2 / 3Recruiting1
DB02300Calcipotriol2 / 3Completed1
DB11750Clobetasol2 / 3Completed1
DB00563Methotrexate2 / 3Recruiting1
DB00596Ulobetasol2 / 3Completed1
DB00459Acitretin3Completed1
DB00051Adalimumab3Active Not Recruiting4
DB00051Adalimumab3Completed10
DB00051Adalimumab3Recruiting2
DB00092Alefacept3Completed1
DB05676Apremilast3Completed1
DB05676Apremilast3Recruiting1
DB01076Atorvastatin3Withdrawn1
DB00443Betamethasone3Completed1
DB00443Betamethasone3Unknown Status1
DB05459Briakinumab3Completed1
DB11776Brodalumab3Completed2
DB11776Brodalumab3Terminated1
DB02300Calcipotriol3Completed1
DB02300Calcipotriol3Not Yet Recruiting1
DB01197Captopril3Completed2
DB08904Certolizumab pegol3Active Not Recruiting3
DB11750Clobetasol3Completed1
DB01013Clobetasol propionate3Completed1
DB11082Coal tar3Not Yet Recruiting1
DB00091Cyclosporine3Completed1
DB00095Efalizumab3Completed5
DB01613Erythrityl Tetranitrate3Active Not Recruiting1
DB00005Etanercept3Active Not Recruiting3
DB00005Etanercept3Completed14
DB00005Etanercept3Recruiting1
DB11834Guselkumab3Active Not Recruiting4
DB11834Guselkumab3Completed1
DB11834Guselkumab3Recruiting2
DB00065Infliximab3Completed8
DB00065Infliximab3Terminated2
DB11569Ixekizumab3Active Not Recruiting5
DB11569Ixekizumab3Completed1
DB00331Metformin3Not Yet Recruiting1
DB00563Methotrexate3Completed5
DB00563Methotrexate3Terminated1
DB11786Pefcalcitol3Completed3
DB00860Prednisolone3Unknown Status1
DB09029Secukinumab3Completed6
DB09029Secukinumab3Recruiting1
DB00864Tacrolimus3Completed3
DB08895Tofacitinib3Completed5
DB08895Tofacitinib3Terminated1
DB05679Ustekinumab3Completed9
DB05679Ustekinumab3Recruiting1
DB05679Ustekinumab3Terminated1
DB11693Voclosporin3Completed3
DB09145Water3Completed1
DB00459Acitretin4Completed2
DB00459Acitretin4Unknown Status1
DB00051Adalimumab4Active Not Recruiting2
DB00051Adalimumab4Completed6
DB00051Adalimumab4Unknown Status1
DB00092Alefacept4Completed1
DB00092Alefacept4Terminated1
DB05676Apremilast4Not Yet Recruiting1
DB05676Apremilast4Recruiting2
DB00443Betamethasone4Completed1
DB02300Calcipotriol4Completed3
DB06774Capsaicin4Terminated1
DB09301Chondroitin sulfate4Completed1
DB04272Citric Acid4Completed1
DB01013Clobetasol propionate4Completed4
DB00838Clocortolone4Completed1
DB00091Cyclosporine4Completed2
DB00091Cyclosporine4Unknown Status1
DB00250Dapsone4Recruiting1
DB01260Desonide4Not Yet Recruiting1
DB00095Efalizumab4Completed4
DB00736Esomeprazole4Not Yet Recruiting1
DB00005Etanercept4Completed13
DB00005Etanercept4Recruiting1
DB00005Etanercept4Terminated1
DB00005Etanercept4Unknown Status2
DB00588Fluticasone propionate4Completed1
DB00158Folic Acid4Active Not Recruiting1
DB00741Hydrocortisone4Completed1
DB00065Infliximab4Completed4
DB00742Mannitol4Completed1
DB00563Methotrexate4Active Not Recruiting1
DB00563Methotrexate4Completed5
DB00563Methotrexate4Recruiting1
DB00764Mometasone4Completed1
DB11063Polysorbate 804Completed1
DB09029Secukinumab4Recruiting1
DB09153Sodium Chloride4Completed1
DB09153Sodium Chloride4Terminated1
DB09154Sodium Citrate4Completed1
DB11151Sodium hydroxide4Completed1
DB09449Sodium phosphate4Completed1
DB00620Triamcinolone4Suspended1
DB05679Ustekinumab4Active Not Recruiting1
DB05679Ustekinumab4Completed2
DB05679Ustekinumab4Unknown Status1
DB09145Water4Completed5
DB09145Water4Recruiting1
DB09145Water4Unknown Status1
DB10318Zoster vaccine4Terminated1
DB00459AcitretinNot AvailableCompleted3
DB00051AdalimumabNot AvailableCompleted5
DB00051AdalimumabNot AvailableRecruiting1
DB00051AdalimumabNot AvailableUnknown Status1
DB00092AlefaceptNot AvailableCompleted1
DB05676ApremilastNot AvailableRecruiting2
DB00443BetamethasoneNot AvailableCompleted1
DB11776BrodalumabNot AvailableNot Yet Recruiting1
DB02300CalcipotriolNot AvailableCompleted1
DB00136CalcitriolNot AvailableCompleted2
DB11121ChloroxylenolNot AvailableActive Not Recruiting1
DB11750ClobetasolNot AvailableCompleted1
DB11750ClobetasolNot AvailableTerminated1
DB01013Clobetasol propionateNot AvailableTerminated1
DB00005EtanerceptNot AvailableActive Not Recruiting2
DB00005EtanerceptNot AvailableCompleted9
DB00005EtanerceptNot AvailableRecruiting1
DB00005EtanerceptNot AvailableTerminated1
DB00005EtanerceptNot AvailableUnknown Status1
DB01047FluocinonideNot AvailableCompleted1
DB01677Fumaric AcidNot AvailableCompleted1
DB00724ImiquimodNot AvailableTerminated1
DB00065InfliximabNot AvailableActive Not Recruiting1
DB00065InfliximabNot AvailableCompleted7
DB00065InfliximabNot AvailableRecruiting1
DB00065InfliximabNot AvailableUnknown Status1
DB06655LiraglutideNot AvailableCompleted1
DB01033MercaptopurineNot AvailableCompleted1
DB00563MethotrexateNot AvailableCompleted3
DB00563MethotrexateNot AvailableRecruiting1
DB03904UreaNot AvailableCompleted1
DB05679UstekinumabNot AvailableActive Not Recruiting2
DB05679UstekinumabNot AvailableCompleted3
DB05679UstekinumabNot AvailableRecruiting2
DB09145WaterNot AvailableActive Not Recruiting1
DB09145WaterNot AvailableCompleted2
DB09145WaterNot AvailableTerminated1
DB00495ZidovudineNot AvailableCompleted1