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Identification
NameNicotinamide
Accession NumberDB02701  (EXPT02307)
TypeSmall Molecule
GroupsApproved
DescriptionAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]
Structure
Thumb
Synonyms
Niacinamide
Nicotinic amide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Niacinamide Inj 100mg/mlLiquid100 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NiacinamideCapsule500 mgOralOrganika Health Products Inc.2001-10-012009-08-05Canada
Niacinamide 100 Mg TabletsTablet100 mgOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Niacinamide 100mgTablet100 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Niacinamide 100mg USP - TabTablet100 mgOralJamieson Laboratories Ltd1997-09-162001-09-14Canada
Niacinamide 500 mgCapsule500 mgOralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Niacinamide 500 Tab 500mgTablet500 mgOralNutri West Products Ltd.1993-12-311997-08-05Canada
Niacinamide 500mgTablet500 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Niacinamide 500mgTablet500 mgOralRx Vitamins Inc.1998-09-252007-10-25Canada
Niacinamide 500mgTablet500 mgOralWn Pharmaceuticals Ltd.2002-04-152005-08-15Canada
Niacinamide 500mg - TabTablet500 mgOralHealth Wise Nutrition Inc.1997-08-151998-08-25Canada
Niacinamide Ctr Srt 500mgTablet, extended release500 mgOralBioenergy Inc.1981-12-311998-06-03Canada
Niacinamide Tab 100mgTablet100 mgOralIcn Canada Ltd.1973-12-311998-08-13Canada
Niacinamide Tab 100mg Yeast FreeTablet100 mgOralVita Health Products Inc1972-12-312002-07-31Canada
Niacinamide Tab 500mgTablet500 mgOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Niacinamide Tab 500mgTablet500 mgOralVita Health Products Inc1979-12-312002-07-31Canada
Niacinamide Tab 500mgTablet500 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Niacinamide Tab 500mgTablet500 mgOralIcn Canada Ltd.1976-12-311998-08-13Canada
Niacinamide Tab 500mgTablet500 mgOralKlaire Labs Inc.1984-12-311999-01-18Canada
Niacinamide Tab 500mgTablet500 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Niacinamide Tab 500mgTablet500 mgOralQuest Vitamins A Div Of Purity Life Health Products1978-12-312001-07-06Canada
Niacinamide-S Tab 50mgTablet50 mgOralNutri West Products Ltd.1991-12-311997-08-05Canada
Nicotamine Tab 500mgTablet500 mgOralLes Produits Naturels Suisse Inc.1985-12-311996-09-09Canada
Vita-acinamid Cap 500mgCapsule500 mgOralLes Laboratoires Vachon Inc.1991-12-311997-02-06Canada
Vitamin B3 Tab 500mgTablet500 mgOralShoppers Drug Mart Inc.1980-12-311997-08-15Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
A.H.C. C-creamCream1 g/50mLTopicalCarver Korea Co.,Ltd2013-07-05Not applicableUs
A.H.C. C-serumCream.6 g/30mLTopicalCarver Korea Co.,Ltd2013-07-05Not applicableUs
A.H.C. C-tonerLiquid2.4 g/120mLTopicalCarver Korea Co.,Ltd2013-07-05Not applicableUs
Ahc Revitalizing Special Gen CreamCream.6 g/50mLTopicalCarver Korea Co.,Ltd2013-07-15Not applicableUs
Ahc Vital C Complex MaskLiquid.6 g/30gTopicalCarver Korea Co.,Ltd2013-08-15Not applicableUs
Ahc Whitening Special Gen CreamCream.6 g/50mLTopicalCarver Korea Co.,Ltd2013-07-15Not applicableUs
Ahc Whitening Special Gen SerumLiquid60 mg/30mLTopicalCarver Korea Co.,Ltd2013-07-15Not applicableUs
Ahc Whitening Special Gen SolutionLiquid2.4 g/120mLTopicalCarver Korea Co.,Ltd2013-07-10Not applicableUs
Ala-C Snail Cell Reparing EssenceLiquid2 g/100mLTopicalDaoomcostech.Co.Ltd.2015-09-03Not applicableUs
An Adc Sp Intensive Moisture EssenceCream1.1 g/55gTopicalAn Co Ltd.2016-05-01Not applicableUs
Aplin Spot All KillCream2 g/100mLTopicalNewizcompany2015-10-01Not applicableUs
Aplin Spot RemoverCream2 g/100mLTopicalNewizcompany2015-10-01Not applicableUs
Aqua Collagen Multi Vitamin Hydro MaskPatch.4 g/20gTopicalNature Republic Co., Ltd.2015-02-01Not applicableUs
Barox White GolfCream3.5 g/50mLTopicalDr.Jang Lab Inc.2015-11-01Not applicableUs
Bellaskin Brightening Contour EssenceCream2 mL/100mLTopicalAjou Medics Co., Ltd2011-09-13Not applicableUs
Bha Blackhead Power LiquidLiquid2 mg/100mLTopicalCosrx Inc.2015-12-23Not applicableUs
Bk Cell 5days Of Secret Snow WhiteningPatch.5 mg/25mLTopicalBnk Co., Ltd.2015-06-01Not applicableUs
Capture C-brightening AmpouleLiquid2 g/50mLTopicalCarver Korea Co.,Ltd2013-07-05Not applicableUs
Cell Renew BioEmulsion3 g/150mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Cell Renew Bio TonerLiquid3 g/150mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Cellpium Double Essence TonerLiquid2.6 g/130mLTopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Cellpium Premiumex Hybrid EssenceCream1 g/50mLTopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Cellpium Premiumex Hybrid TonerLiquid2.4 g/120mLTopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Cellpium Real Mask PackPatch.46 g/31TopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Cellpium Super Richness AmpouleGel.3 g/21TopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Celonia CmSolution.05 g/51TopicalMedipost Co.,Ltd.2016-02-01Not applicableUs
Chaga Anti Wrinkle Eye With Fermented Chaga ExtractCream.4 g/20mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Chaga Anti Wrinkle Skin With Fermented Chaga ExtractLiquid3.2 g/160mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Chaga Anti Wrinkle With Fermented Chaga ExtractEmulsion2.8 g/140mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Costem Cell 5 NSolution.1 g/5mLTopicalCostemcell.ltd.co2016-11-01Not applicableUs
Daily Whitening Care Sheet MaskPatch.46 g/23mLTopicalMiguhara2016-01-02Not applicableUs
Dht X HairlossShampoo1.08 g/360gTopicalIdoogen Co., Ltd.2014-11-01Not applicableUs
Dht X Scalp TShampoo1.2 mg/400mLTopicalIdoogen Co., Ltd.2014-12-01Not applicableUs
Dr Cellinme Mask SheetPatch.6 mg/51TopicalDr.Gene Co.,Ltd2015-06-01Not applicableUs
Dr Cellinme Skin Care AmpouleSolution.1 mg/201TopicalDr.Gene Co.,Ltd2015-06-01Not applicableUs
Dr. CellmoShampoo.51 mg/510mLTopicalPharmacal International. Co., Ltd.2016-08-04Not applicableUs
Dr. Color Effect RedCream1 g/50mLTopicalEs Pure Vine Inc.2016-02-23Not applicableUs
Dr. Color Effect RedCream1 g/50mLTopicalLab & Company Inc.2015-12-01Not applicableUs
Dr.althea Power Whitening GlutathioneCream2 g/100mLTopicalDr. Althea2016-08-11Not applicableUs
Dr.g Hydra VolumeCream2 g/100mLTopicalGOWOONSESANG COSMETICS CO., LTD.2015-07-05Not applicableUs
Dr.g Lock and More A-clear MaskLiquid2 g/100mLTopicalGOWOONSESANG COSMETICS CO., LTD.2015-07-05Not applicableUs
Drh Whitening G2 SerumCream1 g/50mLTopicalNew & New Co.,ltd.2016-10-01Not applicableUs
Edge Cutimal Cat Whitening MaskPatch.5 g/25gTopicalOneskin Cosmetics Co., Ltd.2016-11-01Not applicableUs
Gem Miracle Black Pearl O2 WhiteningEmulsion3 g/150mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Gem Miracle Black Pearl O2 WhiteningCream1.2 g/60mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Gem Miracle Black Pearl O2 Whitening Snow SerumCream1 g/50mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Gem Miracle Black Pearl O2 Whitening TonerLiquid3 g/150mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Ginseng Royal SilkEmulsion2.4 mg/120mLTopicalNature Republic Co., Ltd.2015-09-01Not applicableUs
Ginseng Royal Silk TonerLiquid2.4 mg/120mLTopicalNature Republic Co., Ltd.2015-09-01Not applicableUs
Ginseng WhiteningCream2 g/50gTopicalSynbio Co., Ltd.2016-09-19Not applicableUs
Greentinol Multi TonerSolution2.85 mg/150mLTopicalNature Republic Co., Ltd.2015-10-01Not applicableUs
Hanskin Real ComplexionCream1 g/50gTopicalCelltrion Skincure Co.,ltd.2016-07-01Not applicableUs
It Radiant Brightening TonerLiquid4 mg/200mLTopicalF&Co Co., Ltd.2015-03-01Not applicableUs
Manefit Beauty Planner Lily Brightening Eye MaskCream.2 mg/10gTopicalImine Co., Ltd.2016-03-04Not applicableUs
Manefit Beauty Planner Lily Whitening Brightening MaskCream4.6 mg/23mLTopicalImine Co., Ltd.2014-07-17Not applicableUs
Manefit Beauty Planner Lily Whitening Eye PatchCream.06 g/3gTopicalImine Co., Ltd.2014-07-18Not applicableUs
Manefit Bling Bling Whitening Platinum Hydrogel MaskCream.6 g/30gTopicalImine Co., Ltd.2015-09-07Not applicableUs
Manefit Bling Bling Wrinkle Gold Hydro Gel MaskCream.012 g/30gTopicalImine Co., Ltd.2015-09-07Not applicableUs
Mari Huana Real Natural Sparkle EssenceCream2.8 g/140mLTopicalJunglefood Co., Ltd.2016-04-02Not applicableUs
Mari Huana Real Nature Hemp SeedCream1.4 g/70gTopicalJunglefood Co., Ltd.2016-03-02Not applicableUs
Mineral Homme WhiteEmulsion2.6 g/130mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Mineral Homme White TonerLiquid2.6 g/130mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Mizon Enjoy Vital Up Time Whitening MaskPatch.6 g/101TopicalMizon Co., Ltd.2016-03-02Not applicableUs
Multi Vita 10 Sleeping PackGel5 mg/100mLTopicalWow Ventures2015-05-01Not applicableUs
Neogen Dermalogy Real Fresh Foam CerealGel.16 g/160gTopicalOutin Futures Corp.2015-07-07Not applicableUs
Neogen Dermalogy Real Fresh Foam CranberryGel.16 g/160gTopicalOutin Futures Corp.2015-07-07Not applicableUs
Neogen Dermalogy Real Fresh Foam Green TeaGel.16 g/160gTopicalOutin Futures Corp.2015-07-07Not applicableUs
Niveola P.H.c 3d Festival Mask PackCream.54 g/27gTopicalUnisource International Co., Ltd.2015-10-08Not applicableUs
Niveola White Tiger 3d Animal Mask PackCream.54 g/27gTopicalUnisource International Co., Ltd.2015-10-08Not applicableUs
Primerose Snail Hydro EssenceGel.02 1/120mLTopicalRoyal Springs Cosmetics Usa, Llc2015-06-25Not applicableUs
Pure Vita WhiteLotion2 g/100gTopicalNature Republic Co., Ltd.2015-08-01Not applicableUs
Pure White BrighteningEmulsion2.8 g/140mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Pure White Brightening EssenceCream1.2 g/60mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Pure White Brightening TonerLiquid3.2 g/160mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Re-construct Enriched Nourishing FormulaCream.02 g/55mLTopicalHanaim International Llc2016-11-18Not applicableUs
Revital Perfecting Dual AmpouleSolution.4 mg/20mLTopicalRaonbio Corp2015-07-10Not applicableUs
Saccharomyces The FirstCream1 mg/50mLTopicalNature Republic Co., Ltd.2015-08-01Not applicableUs
Saccharomyces The First EyeCream.5 mg/25mLTopicalNature Republic Co., Ltd.2015-08-01Not applicableUs
Skederm Ultimate EyeCream.3 mg/15mLTopicalSkederm Inc.2015-11-30Not applicableUs
Snail Essential EX Wrinkle EssenceCream1 g/50mLTopicalThe Saem International Co., Ltd.2015-12-01Not applicableUs
Snail Gold Hydro LipPatch.2 g/10gTopicalNature Republic Co., Ltd.2015-06-01Not applicableUs
Snow WhiteCream2 g/100gTopicalZenpia2015-07-05Not applicableUs
Snow White Cleansing FoamCream.1 g/100gTopicalZenpia2015-07-05Not applicableUs
Snow White EssenceLiquid2 g/100mLTopicalZenpia2015-07-05Not applicableUs
Snow White MilkyLotion2 g/100gTopicalZenpia2015-07-05Not applicableUs
Snow White Milky PackCream2 g/100gTopicalZenpia2015-07-05Not applicableUs
Snow White SpotGel2 g/100gTopicalZenpia2015-07-05Not applicableUs
Stem Cell Whitening SerumLiquid.02 mL/mLTopicalMedon Co., Ltd2011-04-06Not applicableUs
The Hayan Cherry Blossom Brightening EssenceCream1.1 g/55mLTopicalTonymoly Co.,Ltd2016-05-01Not applicableUs
Tonymoly Naturalth Goat Milk Whitening EssenceCream1 g/50mLTopicalTonymoly Co.,Ltd2015-12-01Not applicableUs
Tonymoly Naturalth Goat Milk Whitening TonerLiquid3 g/150mLTopicalTonymoly Co.,Ltd2015-12-01Not applicableUs
Tonymoly Pandas Dream White HandCream.6 g/30gTopicalTonymoly Co.,Ltd2015-12-01Not applicableUs
Ts (talmostop)Shampoo.3 mL/100mLTopicalTalmocom Co., Ltd2012-02-01Not applicableUs
Ts (talmostop) Hair TonicLiquid.3 mL/100mLTopicalTalmocom Co., Ltd2012-02-01Not applicableUs
Ts (talmostop) TalhwanPellet.3 g/100gTopicalTalmocom Co., Ltd2012-02-01Not applicableUs
Ultimate Nourishing Rice Overnight Spa MaskCream1 g/50gTopicalCosrx Inc.2016-05-232016-11-08Us
Ultimate Nourishing Rice Overnight Spa MaskCream1.2 g/60gTopicalCosrx Inc.2016-05-23Not applicableUs
Ultra Waterfall CreamCream1 mg/50mLTopicalLisz Kei2015-04-10Not applicableUs
Ultra WhiteningCream1 g/50mLTopicalMiguhara2016-01-02Not applicableUs
Ultra Whitening AmpleCream.7 g/35mLTopicalMiguhara2016-01-02Not applicableUs
Ultra Whitening First EssenceCream2.4 g/120mLTopicalMiguhara2016-01-02Not applicableUs
V V Vitalizing EyeCream.4 mg/20mLTopicalF&Co Co., Ltd.2015-03-01Not applicableUs
V V Vitalizing SerumCream.9 mg/45mLTopicalF&Co Co., Ltd.2015-03-01Not applicableUs
Vita C 35 Tone Up AmpuleLiquid.4 mg/20mLTopicalWow Ventures2015-05-01Not applicableUs
W Lab Snail GreenteaCream1.5 g/75gTopicalWow Ventures2016-10-10Not applicableUs
W Lab Snail Greentea EssenceLiquid1 g/50mLTopicalWow Ventures2016-10-10Not applicableUs
White Vita First EssenceCream3 g/150mLTopicalNature Republic Co., Ltd.2016-03-02Not applicableUs
White Vita FloralEmulsion3 g/150mLTopicalNature Republic Co., Ltd.2015-11-01Not applicableUs
White Vita Floral Essence BrighteningCream2 g/40mLTopicalNature Republic Co., Ltd.2015-12-01Not applicableUs
White Vita Floral TonerLiquid3 g/150mLTopicalNature Republic Co., Ltd.2015-11-01Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Active FeGm Pharmaceuticals, Inc.
Adrenergy TabletsMorter Healthsystem
Aha 7 Whitehead Power LiquidCosrx Inc.
Ahc Revitalizing Special Gen CreamCarver Korea Co.,Ltd
Ahc Revitalizing Special Gen MaskCarver Korea Co.,Ltd
Ahc Revitalizing Special Gen SerumCarver Korea Co.,Ltd
Ahc Revitalizing Special Gen SolutionCarver Korea Co.,Ltd
AlertonicOdan Laboratories Ltd
All New TsTalmocom Co., Ltd
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Always Bright Spot LumedicDms International Co., Ltd.
Am CapsNew Vision Nutritionals Company
Antibe Beausenne Special AmpouleModongee Co., Ltd.
AppedrineChattem Canada
Aqua Bab Modeling MaskZemna Company Co., Ltd
Aqua Collagen Solu Tion Marine Hydroge L Eye Crea M MaskNature Republic Co., Ltd.
ArmaxEnzymatic Therapy (Canada) Inc.
Atono2 Oxygen Mothers CreamLaorganic Co., Ltd.
B 50 CapsulesRheingold Food International Ltd.
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite Llc
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite Llc
B Complex With C 550mgVita Health Products Inc
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300 mgVita Health Products Inc
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B Vitamin Compound With B12 ThunasThuna Herbal Remedies Ltd.
B With C 500 CapPharmetics (2011) Inc
B-100 CapsNow Foods
B-100 Complex TabletsViva Pharmaceutical Inc.
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-comboPerdido Key Health And Wellness Inc
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabSantÉ Naturelle (Ag) LtÉe
B-complex TabletsShaklee Canada Inc
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-plexWn Pharmaceuticals Ltd.
B-plex 100Merit Pharmaceutical
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
B6-niacinamide TabStandard Process Inc.
BacminMarnel Pharmaceuticals, Inc.
Balanced B 125 SrtAnabolic Laboratories Inc.
Balanced B-100 B-complex Vitamins TabPharmavite Llc
Balanced B-100 Timed ReleasePharmavite Llc
Balanced B-50 B-complex Vitamins TabPharmavite Llc
Balanced B-50 B-complex Vitamins, Timed RelePharmavite Llc
Balanced B-50 ComplexLeiner Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beautel Supplement De Vitamines Et MineralNobel Pharm Enr.
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Bev B-150Beverly International Nutrition
Bio-fenLisa & Gerry Freundl
Biovim TabLe Naturiste J.M.B. Inc.
BiovitaIldong Pharmaceutical Co., Ltd.
Birds Nest Forever Young Multi Care LiftingF&Co Co., Ltd.
Bonnoir Hair MediCellinbio Co Ltd
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Canada Inc. Consumer Health Care Division
C-B ComplexAvacare, Division Of Jeunique International Inc.
Camellia Air Cushion 21 Spf50 PaTov Co., Ltd
Camellia Air Cushion 22 Spf50 PaTov Co., Ltd
Camellia Calming Sleeping MaskAmi Cosmetic Co.,Ltd.
Camellia Cc Cream 21 Spf45 PaTov Co., Ltd
Camellia Cc Cream 22 Spf45 PaTov Co., Ltd
Camellia Cooling Cc 21 Spf50 PaTov Co., Ltd
Camellia Cooling Cc 22 Spf50 PaTov Co., Ltd
Camellia Vital Dual SerumTov Co., Ltd
Camellia Wrinkle Free EyeTov Co., Ltd
Capture Collagen AmpouleCarver Korea Co.,Ltd
Carbassist TabletsWyeth Consumer Healthcare Inc.
Carione RgCell Activation Research Institute Co., Ltd
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cellapy HaircellGm Holdings Co., Ltd
Centella 70Ami Cosmetic Co.,Ltd.
Centella 80 EyeAmi Cosmetic Co.,Ltd.
Centella 90 AmpouleAmi Cosmetic Co.,Ltd.
Centella and Green Tea Callus MaskAmi Cosmetic Co.,Ltd.
Centella Reviving TonerAmi Cosmetic Co.,Ltd.
Chela Potassium PlusNu Life Nutrition Ltd.
Chela-chromium 200Nu Life Nutrition Ltd.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children Choice Multivitamin W Iron Chew TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi Vit W IronShoppers Drug Mart Inc.
Children's Chewable Multi VitaminsShoppers Drug Mart Inc.
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple Vit.plus IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc
Children's Vitamins ChewableVita Health Products Inc
Children's Vitamins W Iron ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple VitaminsKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins Plus FeKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins TabPharmavite Llc
Childrens Chewable MultivitaminsRandle Labs Inc.
Childrens Chewable Multivitamins W IronRandle Labs Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc
Childrens Chewable VitaminsD.C. Labs Limited
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Citranatal DHAMission Pharmacal Company
Citranatal RxMission Pharmacal Company
Clapiel Hyalon SerumAus Korea Co., Ltd.
ClerianClerian, Inc.
Clerian Anti-hairlossClerian, Inc.
Clerian HClerian, Inc.
Complete Mega BGahler Enterprises Ltd.
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B Compose 75Les Laboratoires Bio SantÉ Inc.
Complexe B-75Frega Inc.
Croq-vit Pour EnfantsNutrivac Ltee
Daily Energy Brand B-complexEnzymatic Therapy (Canada) Inc.
Denovo 3 HEcomine Co., Ltd.
Derma-forcePrairie Naturals
DermanicAllegis Pharmaceuticals, LLC
Dexatrim TabletsChattem Canada
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Doll LashHanbit Korea
Dong Sung MonelynDaolcosmetic Co.,ltd
Dr.g Brightening Up Cushion Spf50 Plus Pa Plus Plus PlusGOWOONSESANG COSMETICS CO., LTD.
Dr.jart Dermask Micro Jet Clearing SolutionHave & Be Co., Ltd.
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E.S.T. ComplexAbundance Marketing Ltd.
Ecosom TonicEcosom.Co.,Ltd.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Eh Hair Plus Regeneration Hair CareEcobio Medical Institute, Inc.
Enviroflex - TabEnviro Tech International Canada
EscaviteGm Pharmaceuticals, Inc.
Essential B TabletsGeneral Nutrition Canada Inc.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Ez-flexMetagenics, Inc.
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Flinstones Multiple Plus IronMiles Canada Inc. Consumer Health Care Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Canada Inc. Consumer Health Care Division
Flintstones W Extra C TabMiles Canada Inc. Consumer Health Care Division
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
Folcaps Care OneMidlothian Laboratories
Foltabs PrenatalMidlothian Laboratories
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
Formula 6100 CapStandard Process Inc.
Formula 9 TabPure Life International Prods Inc.
Formula CmNutrivention Nutritional Products
Formula CwBody Wise International Llc
Formula Cw-capletBody Wise International Llc
Formula D.S.Golden Pride International
Formula JsNutrivention Nutritional Products
Formula Pro-BBalance Plus, Inc.
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortaplex InjKripps Pharmacy Ltd.
Forty Plus Vitamin SupplementGarden State Nutritionals
Galactomyces 70Ami Cosmetic Co.,Ltd.
Galactomyces 80 Contouring EyeAmi Cosmetic Co.,Ltd.
Galactomyces 90 AmpouleAmi Cosmetic Co.,Ltd.
Galactomyces 95 Whitening Power EssenceCosrx Inc.
Galactomyces and Rice Callus MaskAmi Cosmetic Co.,Ltd.
Galactomyces First EssenceAmi Cosmetic Co.,Ltd.
Galactomyces Radiance TonerAmi Cosmetic Co.,Ltd.
Garfield Chewable Multivits Plus Iron TabWhitehall Robins Inc.
Gemvites Jr Tab ChewablePharmavite Laboratories (1987) Inc.
Geritol LiquidGlaxosmithkline Consumer Healthcare Inc.
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SaltsNot Available
Categories
UNII25X51I8RD4
CAS number98-92-0
WeightAverage: 122.1246
Monoisotopic: 122.048012824
Chemical FormulaC6H6N2O
InChI KeyDFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI
InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
IUPAC Name
pyridine-3-carboxamide
SMILES
NC(=O)C1=CC=CN=C1
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
NAD-dependent protein deacylase sirtuin-5, mitochondrialProteinunknownNot AvailableHumanQ9NXA8 details
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2ProteinunknownNot AvailableHumanQ10588 details
Exotoxin AProteinunknownNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)P11439 details
L-lactate dehydrogenase A chainProteinunknownNot AvailableHumanP00338 details
Poly [ADP-ribose] polymerase 1Proteinunknown
binder
HumanP09874 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
Pathways
PathwayCategorySMPDB ID
Nicotinate and Nicotinamide MetabolismMetabolicSMP00048
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AtorvastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Atorvastatin.Approved
CerivastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Cerivastatin.Withdrawn
Coenzyme Q10The risk or severity of adverse effects can be increased when Nicotinamide is combined with Coenzyme Q10.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nicotinamide.Approved
FluvastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Fluvastatin.Approved
LovastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Lovastatin.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Nicotinamide.Approved, Investigational
MevastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Mevastatin.Experimental
PitavastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Pitavastatin.Approved
PravastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Pravastatin.Approved
RosuvastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Rosuvastatin.Approved
SimvastatinThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Simvastatin.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Nicotinamide.Approved
Food InteractionsNot Available
References
Synthesis Reference

Helmut Beschke, Heinz Friedrich, Klaus-Peter Muller, Gerd Schreyer, “Process for the production of nicotinamide.” U.S. Patent US4314064, issued May, 1949.

US4314064
General ReferencesNot Available
External Links
ATC CodesA11HA01
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9831
Blood Brain Barrier+0.9911
Caco-2 permeable+0.8077
P-glycoprotein substrateNon-substrate0.8778
P-glycoprotein inhibitor INon-inhibitor0.9816
P-glycoprotein inhibitor IINon-inhibitor0.9955
Renal organic cation transporterNon-inhibitor0.8727
CYP450 2C9 substrateNon-substrate0.8702
CYP450 2D6 substrateNon-substrate0.8913
CYP450 3A4 substrateNon-substrate0.7653
CYP450 1A2 substrateNon-inhibitor0.832
CYP450 2C9 inhibitorNon-inhibitor0.9339
CYP450 2D6 inhibitorNon-inhibitor0.9399
CYP450 2C19 inhibitorNon-inhibitor0.9523
CYP450 3A4 inhibitorNon-inhibitor0.9274
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.943
Ames testNon AMES toxic0.9483
CarcinogenicityNon-carcinogens0.9097
BiodegradationNot ready biodegradable0.7807
Rat acute toxicity1.5739 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9947
hERG inhibition (predictor II)Non-inhibitor0.9581
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
CreamTopical1 g/50mL
CreamTopical.6 g/30mL
LiquidTopical2.4 g/120mL
CreamTopical.6 g/50mL
LiquidTopical.6 g/30g
LiquidTopical60 mg/30mL
LiquidTopical2 g/100mL
CreamTopical1.1 g/55g
PatchTopical.4 g/20g
ElixirOral
Tablet, extended releaseOral
InjectionIntramuscular
Injection, solutionIntramuscular; Intravenous
CreamTopical3.5 g/50mL
CreamTopical2 mL/100mL
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
LiquidTopical2 mg/100mL
GranuleOral
PatchTopical.5 mg/25mL
LiquidTopical2 g/50mL
PowderOral
PatchTopical.46 g/31
GelTopical.3 g/21
SolutionTopical.05 g/51
CreamTopical.4 g/20mL
LiquidTopical3.2 g/160mL
EmulsionTopical2.8 g/140mL
TabletOral
SolutionTopical.1 g/5mL
PatchTopical.46 g/23mL
ShampooTopical1.08 g/360g
ShampooTopical1.2 mg/400mL
PatchTopical.6 mg/51
SolutionTopical.1 mg/201
ShampooTopical.51 mg/510mL
CreamTopical2 g/100mL
PatchTopical.5 g/25g
Tablet, effervescentOral
LiquidIntramuscular; Intravenous
CreamTopical1.2 g/60mL
EmulsionTopical2.4 mg/120mL
LiquidTopical2.4 mg/120mL
CreamTopical2 g/50g
SolutionTopical2.85 mg/150mL
CreamTopical1 g/50g
SprayTopical
GelTopical
LiquidTopical4 mg/200mL
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
CreamTopical.2 mg/10g
CreamTopical4.6 mg/23mL
CreamTopical.06 g/3g
CreamTopical.6 g/30g
CreamTopical.012 g/30g
CreamTopical2.8 g/140mL
CreamTopical1.4 g/70g
EmulsionTopical2.6 g/130mL
LiquidTopical2.6 g/130mL
PatchTopical.6 g/101
Liquid; tabletOral
GelTopical5 mg/100mL
LiquidOral
Solution / dropsOral
SolutionIntravenous
SolutionOral
Tablet, chewableOral
SolutionIntramuscular; Intravenous
GelTopical.16 g/160g
TabletOral500 mg
Tablet, extended releaseOral500 mg
LiquidIntramuscular; Intravenous100 mg
TabletOral100 mg
TabletOral50 mg
CreamTopical.54 g/27g
PatchTopical
SyrupOral
Tablet, coatedOral
Capsule, liquid filledOral
ShampooTopical
EmulsionTopical
GelTopical.02 1/120mL
LotionTopical2 g/100g
CreamTopical.02 g/55mL
OilTopical
SolutionTopical.4 mg/20mL
SolutionTopical
CreamTopical1 mg/50mL
CreamTopical.5 mg/25mL
Capsule, gelatin coatedOral
LiquidTopical
CreamTopical.3 mg/15mL
PatchTopical.2 g/10g
CreamTopical
CreamTopical2 g/100g
CreamTopical.1 g/100g
GelTopical2 g/100g
LiquidTopical.02 mL/mL
KitOral
Capsule, extended releaseOral
CapsuleOral
CreamTopical1.1 g/55mL
Capsule; liquidOral
ShampooTopical.3 mL/100mL
LiquidTopical.3 mL/100mL
PelletTopical.3 g/100g
CreamTopical1.2 g/60g
CreamTopical.7 g/35mL
CreamTopical2.4 g/120mL
CreamTopical.4 mg/20mL
CreamTopical.9 mg/45mL
LozengeOral
Kit
LiquidTopical.4 mg/20mL
CapsuleOral500 mg
PowderTopical
InjectionIntravenous
Tablet, film coatedOral
CreamTopical1.5 g/75g
LiquidTopical1 g/50mL
CreamTopical3 g/150mL
EmulsionTopical3 g/150mL
CreamTopical2 g/40mL
LiquidTopical3 g/150mL
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point130 °CPhysProp
boiling point157 °C at 5.00E-04 mm HgPhysProp
water solubility5E+005 mg/L (at 25 °C)MERCK INDEX (1996)
logP-0.37HANSCH,C ET AL. (1995)
logS0.61ADME Research, USCD
pKa3.35 (at 20 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility50.1 mg/mLALOGPS
logP-0.45ALOGPS
logP-0.39ChemAxon
logS-0.39ALOGPS
pKa (Strongest Acidic)13.39ChemAxon
pKa (Strongest Basic)3.63ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area55.98 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity32.98 m3·mol-1ChemAxon
Polarizability11.71 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-004i-0900000000-acb6a21304b0c09c8472View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)splash10-004r-0900000000-ce86dcff0153b66dd538View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-004i-9500000000-790385e574240b8d39deView in MoNA
GC-MSGC-MS Spectrum - GC-MS (2 TMS)splash10-0udi-2910000000-d760b65bb76d6464038eView in MoNA
GC-MSGC-MS Spectrum - GC-MS (1 TMS)splash10-004i-4900000000-47c6f72d1bb5465c1376View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-00di-2900000000-72a7c92eb2667f5b6c3fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9000000000-6486d230a4a2fd4bab0eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-6486d230a4a2fd4bab0eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positivesplash10-0kor-9800000000-89d56b6cb7e033699d24View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-00di-0900000000-eed71abbb10ba926c13dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-00di-3900000000-0c62aa6aba6e23b6c195View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-001i-9100000000-4357a8833611d1756c59View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-001i-9000000000-c9685717817d0081fe6dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-0fc0-9000000000-ec0ccca306f38cf72a78View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-00di-4900000000-f6d71a6c467f84ddd6abView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-001i-9100000000-62c4bd312efbfa37d1a1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-00di-4900000000-05714b528dc84942b9dbView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-001i-9100000000-edb6a77c0dfdcbdacc5dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0900000000-2c7ec333d35eb740520aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0089-9600000000-466f98885e2efba73575View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0ue9-9200000000-6ef8d7e5edcdd0b02758View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-1900000000-f38177aa475e58941088View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00fr-9800000000-6a883d82fcd7c450f6ceView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0006-9000000000-882d0c59d946a5087b9fView in MoNA
MSMass Spectrum (Electron Ionization)splash10-0kor-9600000000-2b1c5667d92bc1b80b36View in MoNA
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPyridinecarboxylic acids and derivatives
Direct ParentNicotinamides
Alternative Parents
Substituents
  • Nicotinamide
  • Heteroaromatic compound
  • Primary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity...
Gene Name:
SIRT5
Uniprot ID:
Q9NXA8
Molecular Weight:
33880.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferase activity
Specific Function:
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Gene Name:
BST1
Uniprot ID:
Q10588
Molecular Weight:
35723.545 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
unknown
General Function:
Nad+-diphthamide adp-ribosyltransferase activity
Specific Function:
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.
Gene Name:
eta
Uniprot ID:
P11439
Molecular Weight:
69283.345 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Nad binding
Specific Function:
Not Available
Gene Name:
LDHA
Uniprot ID:
P00338
Molecular Weight:
36688.465 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Zinc ion binding
Specific Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR...
Gene Name:
PARP1
Uniprot ID:
P09874
Molecular Weight:
113082.945 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23