Polycythemia Vera (PV)

Also known as: Polycythemia vera / Polycythaemia vera / [M]Polycythemia vera / Primary polycythaemia / Vaquez's disease / Primary polycythemia / Polycythemia rubra vera / Polycythaemia rubra vera

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB01008BusulfanBusulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
DB01005HydroxyureaAn antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
DB00888MechlorethamineA vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. [PubChem] The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB01008BusulfanDNAtarget
DB01008BusulfanCytochrome P450 3A4enzyme
DB01008BusulfanGlutathione S-transferase A2enzyme
DB01008BusulfanGlutathione S-transferase A1enzyme
DB01008BusulfanGlutathione S-transferase Mu 1enzyme
DB01008BusulfanGlutathione S-transferase Penzyme
DB01008BusulfanMicrosomal glutathione S-transferase 2enzyme
DB01005HydroxyureaRibonucleoside-diphosphate reductase large subunittarget
DB01005HydroxyureaCytochrome P450 2D6enzyme
DB00888MechlorethamineDNAtarget
DB00888MechlorethamineCholinesteraseenzyme
DrugDrug NamePhaseStatusCount
DB09036Siltuximab0Withdrawn1
DB01169Arsenic trioxide1Terminated1
DB00928Azacitidine1Active Not Recruiting1
DB00958Carboplatin1Active Not Recruiting1
DB00987Cytarabine1Completed1
DB01262Decitabine1Active Not Recruiting1
DB00773Etoposide1Completed1
DB13040Gandotinib1Completed2
DB12325Idasanutlin1Active Not Recruiting1
DB00619Imatinib1Completed1
DB00008Peginterferon alfa-2a1Active Not Recruiting1
DB08877Ruxolitinib1Recruiting1
DB09143Sonidegib1Active Not Recruiting1
DB01268Sunitinib1Completed1
DB01030Topotecan1Active Not Recruiting1
DB07232Veliparib1Active Not Recruiting1
DB02546Vorinostat1Completed1
DB05243XL0191Terminated2
DB00041Aldesleukin1 / 2Completed1
DB00928Azacitidine1 / 2Recruiting1
DB12645Givinostat1 / 2Completed1
DB06469Lestaurtinib1 / 2Unknown Status1
DB11697Pacritinib1 / 2Completed1
DB11759Pevonedistat1 / 2Recruiting1
DB08877Ruxolitinib1 / 2Completed1
DB11581Venetoclax1 / 2Recruiting1
DB00945Acetylsalicylic acid2Recruiting1
DB00945Acetylsalicylic acid2Withdrawn1
DB01008Busulfan2Recruiting1
DB00958Carboplatin2Recruiting1
DB00493Cefotaxime2Active Not Recruiting1
DB00493Cefotaxime2Recruiting1
DB11121Chloroxylenol2Recruiting1
DB00091Ciclosporin2Active Not Recruiting1
DB00758Clopidogrel2Withdrawn1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting3
DB01254Dasatinib2Completed2
DB13900Equine Botulinum Neurotoxin A Immune FAB22Recruiting1
DB13903Equine Botulinum Neurotoxin B Immune FAB22Recruiting1
DB13898Equine Botulinum Neurotoxin C Immune FAB22Recruiting1
DB13902Equine Botulinum Neurotoxin D Immune FAB22Recruiting1
DB13897Equine Botulinum Neurotoxin E Immune FAB22Recruiting1
DB13901Equine Botulinum Neurotoxin F Immune FAB22Recruiting1
DB13899Equine Botulinum Neurotoxin G Immune FAB22Recruiting1
DB00530Erlotinib2Terminated1
DB01073Fludarabine2Active Not Recruiting4
DB01073Fludarabine2Completed1
DB01073Fludarabine2Recruiting3
DB12645Givinostat2Completed1
DB01005Hydroxyurea2Completed1
DB12325Idasanutlin2Recruiting1
DB00619Imatinib2Completed3
DB00480Lenalidomide2Completed1
DB06469Lestaurtinib2Completed1
DB01042Melphalan2Active Not Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB08893Mirabegron2Completed1
DB11763Momelotinib2Completed1
DB11763Momelotinib2Terminated1
DB00688Mycophenolate mofetil2Active Not Recruiting4
DB00688Mycophenolate mofetil2Recruiting2
DB01024Mycophenolic acid2Recruiting1
DB09037Pembrolizumab2Recruiting1
DB08910Pomalidomide2Completed1
DB00635Prednisone2Completed2
DB08877Ruxolitinib2Completed1
DB08877Ruxolitinib2Recruiting2
DB00864Tacrolimus2Active Not Recruiting3
DB00864Tacrolimus2Recruiting2
DB04572Thiotepa2Recruiting1
DB04960Tipifarnib2Completed1
DB01030Topotecan2Recruiting1
DB11940Triapine2Completed1
DB07232Veliparib2Recruiting1
DB02546Vorinostat2Unknown Status1
DB13900Equine Botulinum Neurotoxin A Immune FAB23Active Not Recruiting2
DB13903Equine Botulinum Neurotoxin B Immune FAB23Active Not Recruiting2
DB13898Equine Botulinum Neurotoxin C Immune FAB23Active Not Recruiting2
DB13902Equine Botulinum Neurotoxin D Immune FAB23Active Not Recruiting2
DB13897Equine Botulinum Neurotoxin E Immune FAB23Active Not Recruiting2
DB13901Equine Botulinum Neurotoxin F Immune FAB23Active Not Recruiting2
DB13899Equine Botulinum Neurotoxin G Immune FAB23Active Not Recruiting2
DB01005Hydroxyurea3Active Not Recruiting1
DB01005Hydroxyurea3Completed2
DB01005Hydroxyurea3Terminated1
DB00008Peginterferon alfa-2a3Active Not Recruiting1
DB00022Peginterferon alfa-2b3Active Not Recruiting1
DB08877Ruxolitinib3Active Not Recruiting1
DB08877Ruxolitinib3Completed3
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB01008BusulfanNot AvailableCompleted2
DB00493CefotaximeNot AvailableCompleted1
DB00091CiclosporinNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableCompleted1
DB01073FludarabineNot AvailableCompleted2
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB00619ImatinibNot AvailableCompleted1
DB01042MelphalanNot AvailableCompleted1
DB00563MethotrexateNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00864TacrolimusNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1