Modified vaccinia ankara
Identification
- Summary
Modified vaccinia ankara is a live, non-replicating orthopoxvirus vaccine used to prevent smallpox, monkeypox, and other diseases caused by vaccinia virus.
- Brand Names
- Jynneos
- Generic Name
- Modified vaccinia ankara
- DrugBank Accession Number
- DB15483
- Background
Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).2,3
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Vaccines
Attenuated - Synonyms
- Modified Vaccinia Virus (Ankara-Bavarian Nordic)
- MVA
- MVA-BN
- Vaccinia strain modified ankara
Pharmacology
- Indication
Modified vaccinia ankara is a vaccine indicated for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.1 In the EU, it is additionally indicated for the prevention of other diseases caused by the vaccinia virus.3
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to prevent Ebola virus infection Regimen in combination with: Ebola Zaire vaccine (live, attenuated) (DB15595) •••••••••••• •••••••••• •••••••••• Prevention of Monkeypox •••••••••••• ••••• •••• •••• •••••••••• •••••••••• Prevention of Smallpox •••••••••••• ••••• •••••••••••••••• •• ••••• •• •••••• •••••••••• •••••••• •••••••• •••••••••• ••••••••••• •••••••••• Prevention of Variola major (smallpox) •••••••••••• ••••• •••• •••• ••• •••••••• ••••••••• •••••••••• •••••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
Vaccination with Modified Vaccinia Ankara elicits humoral and cellular immune responses to orthopoxviruses, thereby providing host protection against future orthopoxvirus infections.1
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbatacept The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Abatacept. Adalimumab The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Adalimumab. Adenovirus type 7 vaccine live The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Modified vaccinia ankara. Aldesleukin The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Aldesleukin. Alefacept The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Alefacept. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Imvamune Suspension 50000000 CCID50 / 0.5 mL Subcutaneous Bavarian Nordic As 2015-06-15 Not applicable Canada Imvanex Injection, suspension 50000000 Inf. U Subcutaneous Bavarian Nordic A/S 2020-12-18 Not applicable EU Jynneos Injection, suspension 50000000 1/0.5mL Subcutaneous Bavarian Nordic A/S 2021-03-17 Not applicable US Mvabea Injection, suspension 70000000 Inf. U Intramuscular Janssen Cilag International Nv 2021-02-11 Not applicable EU
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- TU8J357395
- CAS number
- Not Available
References
- General References
- DailyMed Label: JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Non-replicating) suspension for subcutaneous injection [Link]
- FDA Approved Drug Products: Jynneos (smallpox and monkeypox vaccine, live, non-replicating) for suspension for subcutaneous injection [Link]
- EMA Summary of Product Characteristics: Imvanex (Smallpox and monkeypox vaccine (Live Modified Vaccinia Virus Ankara)) for subcutaneous injection [Link]
- Health Canada Product Monograph: IMVAMUNE (modified vaccinia ankara) injection [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Vaccinations 1 4 Not Yet Recruiting Prevention Monkeypox 1 4 Recruiting Prevention Monkeypox 1 3 Active Not Recruiting Prevention Monkeypox Virus Infection 1 3 Completed Prevention 18-42 Year Old Healthy Vaccinia-naïve Subjects 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Suspension Subcutaneous 50000000 CCID50 / 0.5 mL Injection, suspension Subcutaneous 50000000 U.inf. Injection, suspension Subcutaneous 50000000 Inf. U Injection, suspension Subcutaneous 50000000 1/0.5mL Injection, suspension Intramuscular 0.5 ML Injection, suspension Intramuscular 70000000 Inf. U - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
- Not Available
Drug created at August 30, 2019 17:59 / Updated at December 01, 2022 11:29