Identification

Name
Aldesleukin
Accession Number
DB00041  (BTD00082, BIOD00082)
Type
Biotech
Groups
Approved
Biologic Classification
Protein Based Therapies
Interleukin-based products
Description

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.

Protein structure
Db00041
Protein chemical formula
C690H1115N177O202S6
Protein average weight
15314.8 Da
Sequences
>Aldesleukin sequence
MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCL
EEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLN
RWITFCQSIISTLT
Download FASTA Format
Synonyms
  • 125-L-serine-2-133-interleukin 2 (human reduced)
  • Interleukin-2 aldesleukin
  • Interleukin-2(2-133),125-ser
  • Recombinant interleukin-2 human
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ProleukinInjection1.1 mg/mLIntravenousNovartis1992-05-062017-04-15Us
ProleukinPowder, for solution22000000 unitIntravenousNovartis1995-12-31Not applicableCanada
ProleukinInjection, powder, lyophilized, for solution1.1 mg/mLIntravenousPrometheus Laboratories1992-05-05Not applicableUs
Categories
UNII
M89N0Q7EQR
CAS number
110942-02-4

Pharmacology

Indication

For treatment of adults with metastatic renal cell carcinoma.

Structured Indications
Pharmacodynamics

Used to treat renal cell carcinoma, Aldesleukin induces the enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines, the enhancement of lymphocyte cytotoxicity, the induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity; and the induction of interferon-gamma production. IL-2 is normally produced by the body, secreted by T cells, and stimulates growth and differentiation of T cell response. It can be used in immunotherapy to treat cancer. It enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor.

Mechanism of action

Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.

TargetActionsOrganism
AInterleukin-2 receptor subunit beta
agonist
modulator
Human
AInterleukin-2 receptor subunit alpha
agonist
modulator
Human
ACytokine receptor common subunit gamma
agonist
Human
Absorption
Not Available
Volume of distribution

0.18 l/kg

Protein binding
Not Available
Metabolism
Not Available
Route of elimination

The pharmacokinetic profile of Proleukin is characterized by high plasma concentrations following a short IV infusion, rapid distribution into the extravascular space and elimination from the body by metabolism in the kidneys with little or no bioactive protein excreted in the urine. Following the initial rapid organ distribution, the primary route of clearance of circulating proleukin is the kidney. Greater than 80% of the amount of Proleukin distributed to plasma, cleared from the circulation and presented to the kidney is metabolized to amino acids in the cells lining the proximal convoluted tubules.

Half life

13 min-85 min

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-Bromoepiandrosterone16-Bromoepiandrosterone may decrease the antineoplastic activities of Aldesleukin.Investigational
19-norandrostenedione19-norandrostenedione may decrease the antineoplastic activities of Aldesleukin.Experimental, Illicit
5-androstenedione5-androstenedione may decrease the antineoplastic activities of Aldesleukin.Experimental, Illicit
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Aldesleukin.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Aldesleukin.Experimental
AlclometasoneAlclometasone may decrease the antineoplastic activities of Aldesleukin.Approved
AldosteroneAldosterone may decrease the antineoplastic activities of Aldesleukin.Experimental, Investigational
AmcinonideAmcinonide may decrease the antineoplastic activities of Aldesleukin.Approved
AncestimThe risk or severity of cytotoxicity can be increased when Ancestim is combined with Aldesleukin.Approved, Investigational, Withdrawn
AndrostenedioneAndrostenedione may decrease the antineoplastic activities of Aldesleukin.Experimental, Illicit
AnecortaveAnecortave may decrease the antineoplastic activities of Aldesleukin.Investigational
anecortave acetateanecortave acetate may decrease the antineoplastic activities of Aldesleukin.Investigational
AtamestaneAtamestane may decrease the antineoplastic activities of Aldesleukin.Investigational
AtorvastatinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Atorvastatin.Approved
Beclomethasone dipropionateBeclomethasone dipropionate may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
BetamethasoneBetamethasone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Aldesleukin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Aldesleukin.Approved
BudesonideBudesonide may decrease the antineoplastic activities of Aldesleukin.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Aldesleukin.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Aldesleukin.Withdrawn
CiclesonideCiclesonide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
ClobetasolClobetasol may decrease the antineoplastic activities of Aldesleukin.Investigational
Clobetasol propionateClobetasol propionate may decrease the antineoplastic activities of Aldesleukin.Approved
ClobetasoneClobetasone may decrease the antineoplastic activities of Aldesleukin.Approved
ClocortoloneClocortolone may decrease the antineoplastic activities of Aldesleukin.Approved
Cortexolone 17α-propionateCortexolone 17α-propionate may decrease the antineoplastic activities of Aldesleukin.Investigational
CorticosteroneCorticosterone may decrease the antineoplastic activities of Aldesleukin.Experimental
Cortisone acetateCortisone acetate may decrease the antineoplastic activities of Aldesleukin.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Aldesleukin.Approved, Investigational
CymarinCymarin may decrease the cardiotoxic activities of Aldesleukin.Experimental
DeflazacortDeflazacort may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
DeslanosideDeslanoside may decrease the cardiotoxic activities of Aldesleukin.Approved
DesonideDesonide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
DesoximetasoneDesoximetasone may decrease the antineoplastic activities of Aldesleukin.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may decrease the antineoplastic activities of Aldesleukin.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may decrease the antineoplastic activities of Aldesleukin.Experimental, Vet Approved
DexamethasoneDexamethasone may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may decrease the antineoplastic activities of Aldesleukin.Vet Approved
DiflorasoneDiflorasone may decrease the antineoplastic activities of Aldesleukin.Approved
DifluocortoloneDifluocortolone may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational, Withdrawn
DifluprednateDifluprednate may decrease the antineoplastic activities of Aldesleukin.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Aldesleukin.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Aldesleukin.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Aldesleukin.Approved
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Aldesleukin.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Aldesleukin.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Aldesleukin.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Aldesleukin.Approved
EquileninEquilenin may decrease the antineoplastic activities of Aldesleukin.Experimental
EquilinEquilin may decrease the antineoplastic activities of Aldesleukin.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Aldesleukin.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Aldesleukin.Approved
EstroneEstrone may decrease the antineoplastic activities of Aldesleukin.Approved
Estrone sulfateEstrone sulfate may decrease the antineoplastic activities of Aldesleukin.Approved
FluasteroneFluasterone may decrease the antineoplastic activities of Aldesleukin.Investigational
FludrocortisoneFludrocortisone may decrease the antineoplastic activities of Aldesleukin.Approved
FlumethasoneFlumethasone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
FlunisolideFlunisolide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
Fluocinolone AcetonideFluocinolone Acetonide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational
FluocortoloneFluocortolone may decrease the antineoplastic activities of Aldesleukin.Approved, Withdrawn
FluorometholoneFluorometholone may decrease the antineoplastic activities of Aldesleukin.Approved
FluprednideneFluprednidene may decrease the antineoplastic activities of Aldesleukin.Approved, Withdrawn
FluprednisoloneFluprednisolone may decrease the antineoplastic activities of Aldesleukin.Approved
FlurandrenolideFlurandrenolide may decrease the antineoplastic activities of Aldesleukin.Approved
Fluticasone furoateFluticasone furoate may decrease the antineoplastic activities of Aldesleukin.Approved
Fluticasone propionateFluticasone propionate may decrease the antineoplastic activities of Aldesleukin.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Aldesleukin.Approved
FormestaneFormestane may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational, Withdrawn
GitoformateGitoformate may decrease the cardiotoxic activities of Aldesleukin.Experimental
HalcinonideHalcinonide may decrease the antineoplastic activities of Aldesleukin.Approved, Investigational, Withdrawn
HE3286HE3286 may decrease the antineoplastic activities of Aldesleukin.Investigational
HydrocortisoneHydrocortisone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Aldesleukin.Approved
Interferon Alfa-2a, RecombinantThe risk or severity of adverse effects can be increased when Interferon Alfa-2a, Recombinant is combined with Aldesleukin.Approved, Investigational
Interferon Alfa-2b, RecombinantThe risk or severity of adverse effects can be increased when Interferon Alfa-2b, Recombinant is combined with Aldesleukin.Approved
Interferon alfa-n3The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Aldesleukin.Approved, Investigational
Interferon alfacon-1The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Aldesleukin.Approved, Investigational
IstaroximeIstaroxime may decrease the antineoplastic activities of Aldesleukin.Investigational
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Aldesleukin.Experimental
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Aldesleukin.Approved, Investigational
LoteprednolLoteprednol may decrease the antineoplastic activities of Aldesleukin.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Aldesleukin.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Aldesleukin.Illicit, Investigational, Withdrawn
ME-609ME-609 may decrease the antineoplastic activities of Aldesleukin.Investigational
MedrysoneMedrysone may decrease the antineoplastic activities of Aldesleukin.Approved
MelengestrolMelengestrol may decrease the antineoplastic activities of Aldesleukin.Vet Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Aldesleukin.Experimental
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Aldesleukin.Approved
MethylprednisoloneMethylprednisolone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Aldesleukin.Approved
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Aldesleukin.Experimental
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Aldesleukin.Experimental
MometasoneMometasone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
NCX 1022NCX 1022 may decrease the antineoplastic activities of Aldesleukin.Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Aldesleukin.Approved, Investigational
OleandrinOleandrin may decrease the cardiotoxic activities of Aldesleukin.Experimental, Investigational
Oleoyl-estroneOleoyl-estrone may decrease the antineoplastic activities of Aldesleukin.Investigational
OuabainOuabain may decrease the cardiotoxic activities of Aldesleukin.Approved
ParamethasoneParamethasone may decrease the antineoplastic activities of Aldesleukin.Approved
Peginterferon alfa-2aThe risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Aldesleukin.Approved, Investigational
Peginterferon alfa-2bThe risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Aldesleukin.Approved
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Aldesleukin.Approved, Investigational, Vet Approved, Withdrawn
PeruvosidePeruvoside may decrease the cardiotoxic activities of Aldesleukin.Experimental
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Aldesleukin.Approved
PrasteronePrasterone may decrease the antineoplastic activities of Aldesleukin.Approved, Nutraceutical
Prasterone sulfatePrasterone sulfate may decrease the antineoplastic activities of Aldesleukin.Investigational
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Aldesleukin.Approved
PrednicarbatePrednicarbate may decrease the antineoplastic activities of Aldesleukin.Approved
PrednisolonePrednisolone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
PrednisonePrednisone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
PregnenolonePregnenolone may decrease the antineoplastic activities of Aldesleukin.Experimental, Investigational
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Aldesleukin.Experimental
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Aldesleukin.Approved
RimexoloneRimexolone may decrease the antineoplastic activities of Aldesleukin.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Aldesleukin.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Aldesleukin.Approved
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Aldesleukin.Experimental
TixocortolTixocortol may decrease the antineoplastic activities of Aldesleukin.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Aldesleukin.Approved
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Aldesleukin.Approved, Investigational
TriamcinoloneTriamcinolone may decrease the antineoplastic activities of Aldesleukin.Approved, Vet Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Aldesleukin.Approved, Investigational, Nutraceutical
UlobetasolUlobetasol may decrease the antineoplastic activities of Aldesleukin.Approved
Food Interactions
Not Available

References

Synthesis Reference

Hans-Ake Fabricius, Roland Stahn, "Serum-free and mitogen-free T-cell growth factor and process for making same." U.S. Patent US4464355, issued May, 1971.

US4464355
General References
Not Available
External Links
UniProt
P60569
Genbank
M11144
PubChem Substance
46508054
ChEMBL
CHEMBL1201438
Therapeutic Targets Database
DAP001099
PharmGKB
PA448081
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Aldesleukin
ATC Codes
L03AC01 — Aldesleukin
AHFS Codes
  • 10:00.00 — Antineoplastic Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentMelanoma (Skin) / Renal Cancers1
0CompletedTreatmentRenal Cancers1
0RecruitingTreatmentMelanoma (Skin) / Skin Cancers1
0RecruitingTreatmentMetastatic Non-Small Cell Lung Cancer1
1Active Not RecruitingTreatmentLymphoma, B-Cell / Malignant Lymphomas1
1Active Not RecruitingTreatmentMelanoma (Skin)1
1Active Not RecruitingTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1Active Not RecruitingTreatmentVascularized Composite Allotransplantation1
1CompletedTreatmentAnaplastic Astrocytoma (AA) / Anaplastic Ependymoma / Anaplastic Meningioma / Anaplastic Oligodendroglioma (AO) / Brain Stem Gliomas / Ependymoblastoma / Giant Cell Glioblastoma / Glioblastomas / Gliosarcoma / Grade III Meningioma / Meningeal Hemangiopericytoma / Mixed Gliomas / Neoplasms, Brain / Pineal Gland Astrocytoma1
1CompletedTreatmentB-Cell Chronic Lymphocytic Leukemia / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Splenic Marginal Zone Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
1CompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Splenic Marginal Zone Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma1
1CompletedTreatmentBrain and Central Nervous System Tumors1
1CompletedTreatmentCancer, Breast1
1CompletedTreatmentCancer, Breast / Metastatic Cancers1
1CompletedTreatmentCancer, Ovarian1
1CompletedTreatmentCancers1
1CompletedTreatmentCytomegalovirus Retinitis / Human Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
1CompletedTreatmentDisseminated Neuroblastoma / Recurrent Neuroblastoma / Regional Neuroblastoma1
1CompletedTreatmentDrug Extravasation / Renal Cancers1
1CompletedTreatmentHigh-risk Tumor / Malignant Lymphomas / Neuroblastomas1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections9
1CompletedTreatmentLeukemias1
1CompletedTreatmentLeukemias / Malignant Lymphomas1
1CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm1
1CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1CompletedTreatmentLeukemias / Myelodysplastic Syndrome1
1CompletedTreatmentLeukemias / Myelodysplastic Syndromes1
1CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
1CompletedTreatmentMalignant Lymphomas4
1CompletedTreatmentMalignant Lymphomas / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentMelanoma1
1CompletedTreatmentMelanoma (Skin)5
1CompletedTreatmentMelanoma (Skin) / Renal Cancers1
1CompletedTreatmentMelanoma / Renal Cancers1
1CompletedTreatmentMetastatic Melanoma / Renal Cell Adenocarcinoma1
1CompletedTreatmentNeuroblastomas1
1CompletedTreatmentOvarian Cancer Metastatic1
1CompletedTreatmentRecurrent Melanoma / Stage IV Melanoma2
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific2
1CompletedTreatmentWiskott-Aldrich Syndrome (WAS) / X-linked Thrombocytopenia1
1Enrolling by InvitationTreatmentEsophageal Cancers / Gallbladder Cancer / Liver Cancer / Malignant intestinal neoplasms / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach1
1Not Yet RecruitingTreatmentClear Cell Renal Cell Carcinoma / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1Not Yet RecruitingTreatmentGastrointestinal Cancer Metastatic1
1Not Yet RecruitingTreatmentPlatinum Resistant Ovarian Cancer1
1RecruitingBasic ScienceSoft Tissue Sarcoma Adult1
1RecruitingTreatmentAdenocarcinomas / Advanced NSCLC / Carcinoma, Adenosquamous / Lung Cancer Non-Small Cell Cancer (NSCLC) / Metastatic Non-Small Cell Lung Cancer / Squamous Cell Carcinoma (SCC)1
1RecruitingTreatmentAdult Solid Neoplasm / Childhood Solid Neoplasm / Neoplasms, Metastatic1
1RecruitingTreatmentAnal Carcinoma / Carcinoma in Situ / Cervical Cancers / Cervical Intraepithelial Neoplasia (CIN) / Oropharyngeal Cancers / Papillomavirus Infections / Penile Cancer / Vaginal Cancers / Vulvar Diseases / Vulvar Neoplasms1
1RecruitingTreatmentCancers / Head and Neck Squamous Cell Carcinoma (HNSCC) / Squamous Cell Non-small Cell Lung Cancer / Tumors, Solid1
1RecruitingTreatmentCancers / Tumors, Solid1
1RecruitingTreatmentChronic Graft Versus Host Disease1
1RecruitingTreatmentFallopian Tube Carcinoma / Ovarian Carcinoma / Primary Peritoneal Cancer / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma1
1RecruitingTreatmentHLA-A*0201 Positive Cells Present / Locally Advanced Malignant Neoplasm / NY-ESO-1 Positive / Unresectable Malignant Neoplasm1
1RecruitingTreatmentHigh Grade Squamous Intraepithelial Lesion / HPV-16 / Human Papillomavirus1
1RecruitingTreatmentMelanoma2
1RecruitingTreatmentMelanoma and Other Malignant Neoplasms of Skin1
1RecruitingTreatmentMetastatic Renal Cell Carcinoma1
1RecruitingTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentCancer, Breast / Cancer, Ovarian / Colorectal Cancers / Lung Cancers / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach / Unspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentCancer, Breast / Malignant Lymphomas1
1TerminatedTreatmentChronic Hepatitis C Infection1
1TerminatedTreatmentInfection, Human Immunodeficiency Virus I1
1TerminatedTreatmentLung Cancers1
1TerminatedTreatmentMelanoma / Metastatic Cancers1
1TerminatedTreatmentMetastatic Cancers1
1TerminatedTreatmentNeuroblastomas1
1TerminatedTreatmentRecurrent Neuroblastoma1
1TerminatedTreatmentRenal Cancers1
1TerminatedTreatmentStage IV Melanoma1
1TerminatedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1Unknown StatusTreatmentCancer, Breast1
1Unknown StatusTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1Unknown StatusTreatmentMalignant Lymphomas1
1Unknown StatusTreatmentNeuroblastomas / Sarcomas1
1WithdrawnTreatmentMalignant Ovarian Clear Cell Tumor / Malignant Ovarian Serous Tumor / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer / Stage IV Primary Peritoneal Cancer1
1WithdrawnTreatmentMetastatic Melanoma1
1, 2Active Not RecruitingBasic ScienceDiabetes, Diabetes Mellitus Type 11
1, 2Active Not RecruitingTreatmentAdvanced Pleural Malignant Mesothelioma / HLA-A*0201 Positive Cells Present / Recurrent Non-Small Cell Lung Carcinoma / Recurrent Pleural Malignant Mesothelioma / Stage III Non-Small Cell Lung Cancer / Stage III Non-Small Cell Lung Cancer AJCC v7 / Stage III Pleural Malignant Mesothelioma AJCC v7 / Stage III Pleural Mesothelioma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIb Non-small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer AJCC v7 / Stage IV Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer AJCC v7 / Stage IV Pleural Malignant Mesothelioma AJCC v7 / Stage IV Pleural Mesothelioma / WT1 Positive1
1, 2Active Not RecruitingTreatmentClear Cell Renal Cell Carcinoma / Metastatic Renal Cell Cancer / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1, 2Active Not RecruitingTreatmentEwing's Sarcoma (ES) / Lung Cancer Metastatic / Sarcoma, Osteogenic / Sarcomas / Tumors, Solid1
1, 2Active Not RecruitingTreatmentMelanoma1
1, 2Active Not RecruitingTreatmentPancreatic Adenocarcinoma Metastatic / Recurrent Pancreatic Carcinoma / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
1, 2Active Not RecruitingTreatmentTransplantation, Kidney1
1, 2CompletedBasic ScienceDiabetes, Diabetes Mellitus Type 11
1, 2CompletedTreatmentAcute Myelogenous Leukaemia (AML)1
1, 2CompletedTreatmentAdult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / Essential Thrombocythemia (ET) / Polycythemia Vera (PV) / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
1, 2CompletedTreatmentCancer, Breast / Cancer, Ovarian1
1, 2CompletedTreatmentColorectal Cancers1
1, 2CompletedTreatmentCryoglobulinemia Vasculitis1
1, 2CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
1, 2CompletedTreatmentGlomerulonephritis minimal lesion1
1, 2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm1
1, 2CompletedTreatmentIntraocular Melanoma / Melanoma (Skin)1
1, 2CompletedTreatmentLeukemias2
1, 2CompletedTreatmentLeukemias / Malignant Lymphomas1
1, 2CompletedTreatmentMalignant Lymphomas1
1, 2CompletedTreatmentMelanoma1
1, 2CompletedTreatmentMelanoma (Skin)4
1, 2CompletedTreatmentMetastatic Cancers / Metastatic Melanoma / Renal Cancers1
1, 2CompletedTreatmentMetastatic Cancers / Renal Cancers1
1, 2CompletedTreatmentMetastatic Melanoma / Metastatic Renal Cell Carcinoma1
1, 2CompletedTreatmentNeuroblastomas1
1, 2CompletedTreatmentProstate Cancer1
1, 2CompletedTreatmentRecurrent Melanoma / Stage IV Melanoma2
1, 2CompletedTreatmentRenal Cancers1
1, 2No Longer AvailableNot AvailableMelanoma (Skin)1
1, 2Not Yet RecruitingTreatmentDiabetes Mellitus (DM) / Diabetes, Autoimmune / Diabetes, Diabetes Mellitus Type 11
1, 2Not Yet RecruitingTreatmentInflammation, Brain1
1, 2RecruitingTreatmentAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Myelodysplastic Syndrome / Childhood Myelodysplastic Syndrome / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Secondary Acute Myeloid Leukemia / Therapy-Related Acute Myeloid Leukemia1
1, 2RecruitingTreatmentBladder Cancers / Cancer, Breast / Cervical Cancers / Malignant Melanoma / Melanoma / Metastatic Cancer That Express the MAGE-A3-HLA A01 Antigen / Metastatic Cancers / Metastatic Melanoma That Express the MAGE-A3-HLA A01 Antigen / Oesophageal Carcinoma / Renal Cancers / Sarcomas / Urothelial Cancer1
1, 2RecruitingTreatmentBrain Cancer / Glioblastomas / Malignant Gliomas1
1, 2RecruitingTreatmentCancer, Breast / Cancer, Ovarian / CD70 Expressing Cancers / Malignant Neoplasm of Pancreas / Melanoma / Renal Cell Adenocarcinoma1
1, 2RecruitingTreatmentCancer, Ovarian / Cervical Cancers / Lung Cancers / Malignant Neoplasm of Pancreas / Mesothelioma / Metastatic Cancers / Ovarian1
1, 2RecruitingTreatmentCancers1
1, 2RecruitingTreatmentDesmoplastic Small Round Cell Tumor (DSRCT) / Disseminated Neuroblastoma / Metastatic Osteosarcoma / Recurrent Neuroblastoma / Recurrent Osteosarcoma1
1, 2RecruitingTreatmentGastrointestinal Cancers / Malignant Neoplasm of Colon / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach / Rectal Carcinoma1
1, 2RecruitingTreatmentIschaemic Heart Diseases1
1, 2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
1, 2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia1
1, 2RecruitingTreatmentLeukemia, Myelomonocytic, Chronic1
1, 2RecruitingTreatmentLeukemias1
1, 2RecruitingTreatmentMelanoma1
1, 2RecruitingTreatmentMetastatic Melanoma1
1, 2RecruitingTreatmentMetastatic Renal Cell Carcinoma1
1, 2RecruitingTreatmentPleural Mesotheliomas1
1, 2TerminatedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Blastic Phase Chronic Myelogenous Leukemia / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia1
1, 2TerminatedTreatmentLeukemias / Malignant Lymphomas1
1, 2TerminatedTreatmentMalignant Melanoma / Melanoma / Melanoma, Experimental1
1, 2TerminatedTreatmentMetastatic Cancers1
1, 2TerminatedTreatmentMetastatic Cancers / Metastatic Melanoma / Metastatic Renal Cancer1
1, 2TerminatedTreatmentRecurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Mycosis Fungoides/Sezary Syndrome / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Mycosis Fungoides/Sezary Syndrome / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome1
1, 2TerminatedTreatmentRecurrent Melanoma / Stage III Melanoma / Stage IV Melanoma1
1, 2TerminatedTreatmentRecurrent Merkel Cell Carcinoma / Stage IV Merkel Cell Carcinoma1
1, 2Unknown StatusTreatmentCancer, Breast1
1, 2Unknown StatusTreatmentMelanoma (Skin)1
1, 2Unknown StatusTreatmentNeuroblastomas1
1, 2WithdrawnTreatmentCancer, Breast1
1, 2WithdrawnTreatmentMelanoma1
1, 2WithdrawnTreatmentMetastatic Thyroid Cancer1
2Active Not RecruitingPreventionGraft Versus Host Disease (GVHD)1
2Active Not RecruitingTreatmentChronic Graft Versus Host Disease1
2Active Not RecruitingTreatmentHigh Risk Non-Hodgkin's Lymphoma1
2Active Not RecruitingTreatmentLeukemias1
2Active Not RecruitingTreatmentMalignant Lymphomas1
2Active Not RecruitingTreatmentMelanoma2
2Active Not RecruitingTreatmentMetastatic Melanoma2
2Active Not RecruitingTreatmentMetastatic Melanoma / Recurrent Melanoma / Stage III Cutaneous Melanoma AJCC v7 / Stage IIIA Cutaneous Melanoma AJCC v7 / Stage IIIA Skin Melanoma / Stage IIIB Cutaneous Melanoma AJCC v7 / Stage IIIB Skin Melanoma / Stage IIIC Cutaneous Melanoma AJCC v7 / Stage IIIC Skin Melanoma / Stage IV Cutaneous Melanoma AJCC v6 and v7 / Stage IV Skin Melanoma1
2Active Not RecruitingTreatmentMetastatic Melanoma / Skin Cancers1
2Active Not RecruitingTreatmentMetastatic Ocular Melanoma / Metastatic Uveal Melanoma1
2Active Not RecruitingTreatmentRecurrent Melanoma / Stage IIIA Melanoma / Stage IIIB Melanoma / Stage IIIc Melanoma / Stage IV Melanoma1
2Active Not RecruitingTreatmentStage IIIA Skin Melanoma / Stage IIIB Skin Melanoma / Stage IIIC Skin Melanoma / Stage IV Skin Melanoma / Stages III Skin Melanoma1
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / All / Chronic Myelogenous Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Myelodysplastic Syndrome / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL) / Non-malignant Diseases Requiring Allogeneic HSCT1
2CompletedTreatmentAdult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Childhood Acute Myeloid Leukemia in Remission / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAnal Carcinoma / Cervical Cancers / Oropharyngeal Cancers / Penile Cancer / Vaginal Cancers2
2CompletedTreatmentAnti-p53 TCR-Gene1
2CompletedTreatmentBrain and Central Nervous System Tumors3
2CompletedTreatmentCancer, Breast / Cancer, Ovarian / Cervical Cancers / Colorectal Cancers / Lung Cancers / Malignant Neoplasm of Pancreas1
2CompletedTreatmentCancer, Breast / Cancer, Ovarian / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Neuroblastomas / Renal Cancers / Sarcomas / Testicular germ cell tumour1
2CompletedTreatmentCancer, Breast / Esophageal Cancers / Lung Cancers / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentChronic Myelogenous Leukemia (CML) / Leukemias1
2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentColorectal Cancers / Endometrial Cancers / Head and Neck Carcinoma / Liver Cancer / Lung Cancers / Malignant Neoplasm of Pancreas / Melanoma (Skin) / Testicular germ cell tumour / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentEstrogen Receptor-negative Breast Cancer / Estrogen Receptor-Positive Breast Cancer / Inflammatory carcinoma of the breast / Male Breast Cancer / Progesterone Receptor-negative Breast Cancer / Progesterone Receptor-positive Breast Cancer / Stage IIIB Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentHer2-Positive Breast Cancer / Male Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections10
2CompletedTreatmentLeukemias4
2CompletedTreatmentLiver Cancer1
2CompletedTreatmentMalignant Lymphomas3
2CompletedTreatmentMalignant Lymphomas / Unspecified Adult Solid Tumor, Protocol Specific / Unspecified Childhood Solid Tumor, Protocol Specific1
2CompletedTreatmentMalignant Melanoma1
2CompletedTreatmentMalignant Melanoma / Melanoma / Melanoma, Experimental1
2CompletedTreatmentMelanoma1
2CompletedTreatmentMelanoma (Skin)20
2CompletedTreatmentMelanoma (Skin) / Renal Cancers1
2CompletedTreatmentMelanoma (Skin) / Renal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentMelanoma (Skin) / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentMelanoma / Metastatic Melanoma / Skin Cancers1
2CompletedTreatmentMelanoma / Skin Cancers2
2CompletedTreatmentMetastatic Kidney Cancer / Metastatic Melanoma1
2CompletedTreatmentMetastatic Melanoma1
2CompletedTreatmentMetastatic Melanoma / Skin Cancers2
2CompletedTreatmentMetastatic Renal Cell Carcinoma1
2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
2CompletedTreatmentProstate Cancer1
2CompletedTreatmentRecurrent Melanoma / Stage IV Melanoma1
2CompletedTreatmentRecurrent Renal Cell Cancer / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
2CompletedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2CompletedTreatmentRenal Cancers4
2CompletedTreatmentRenal Cell Carcinoma Recurrent / Stage IV Renal Cell Cancer1
2CompletedTreatmentStage IV Melanoma1
2Not Yet RecruitingBasic ScienceHuman Immunodeficiency Virus (HIV) Infections1
2Not Yet RecruitingBasic ScienceLupus Erythematosus, Systemic1
2Not Yet RecruitingPreventionMelanoma (Skin) / Melanoma In Situ1
2RecruitingBasic ScienceTransplantation, Liver1
2RecruitingTreatmentAdenocarcinomas / Advanced Non-Small Cell Lung Cancer / Advanced NSCLC / Carcinoma, Adenosquamous / Metastatic Non-Small Cell Lung Cancer / Squamous Cell Carcinoma (SCC)1
2RecruitingTreatmentCancer, Breast / Cervical Cancers / Malignant Melanoma / Melanoma / Metastatic Cancer That Express the MAGE-A3-DP4 Antigen / Oesophageal Carcinoma / Renal Cancers / Sarcomas / Urothelial Cancer1
2RecruitingTreatmentCancer, Breast / Hepatocellular Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Melanoma / Metastatic Cancers Other Than Melanoma That Express ESO Antigen / Synovial Sarcoma1
2RecruitingTreatmentChronic Graft Versus Host Disease1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Leukemias / Myeloid Leukemias1
2RecruitingTreatmentMelanoma3
2RecruitingTreatmentMetastatic Cholangiocarcinoma / Metastatic Colorectal Cancers / Metastatic Gastric Cancers / Metastatic Hepatocellular Carcinoma / Pancreatic Cancer Metastatic1
2RecruitingTreatmentMetastatic Melanoma2
2RecruitingTreatmentMetastatic Melanoma / Stage III Mucosal Melanoma of the Head and Neck / Stage IIIA Skin Melanoma / Stage IIIB Skin Melanoma / Stage IIIC Skin Melanoma / Stage IV Skin Melanoma / Stage IVA Mucosal Melanoma of the Head and Neck / Stage IVB Mucosal Melanoma of the Head and Neck / Stage IVC Mucosal Melanoma of the Head and Neck1
2RecruitingTreatmentNeoplasms, Malignant1
2RecruitingTreatmentNeuroblastomas1
2RecruitingTreatmentRecurrent B-Cell Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood B-Lymphoblastic Lymphoma1
2RecruitingTreatmentRenal Cancers1
2RecruitingTreatmentRenal Cell Adenocarcinoma1
2SuspendedTreatmentBrain and Central Nervous System Tumors1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Myelogenous Leukemia (CML) / Granulocytic Sarcoma / Juvenile Myelomonocytic Leukemia (JMML) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentCancer, Ovarian / Fallopian Tube Cancer / Peritoneal Cavity Cancer1
2TerminatedTreatmentLeukemias1
2TerminatedTreatmentLeukemias / Myelodysplastic Syndromes1
2TerminatedTreatmentLeukemias / Pediatric Cancer1
2TerminatedTreatmentMalignant Lymphomas1
2TerminatedTreatmentMelanoma2
2TerminatedTreatmentMelanoma (Skin)2
2TerminatedTreatmentMelanoma (Skin) / Renal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
2TerminatedTreatmentMelanoma / Skin Cancers2
2TerminatedTreatmentMetastatic Cancers / Metastatic Melanoma1
2TerminatedTreatmentMetastatic Cancers / Metastatic Melanoma / Metastatic Renal Cell Cancer1
2TerminatedTreatmentMetastatic Cutaneous Melanoma1
2TerminatedTreatmentMetastatic Melanoma / Metastatic Renal Cancer1
2TerminatedTreatmentMetastatic Melanoma / Skin Cancers3
2TerminatedTreatmentNeoplasms, Ovarian1
2TerminatedTreatmentNeuroblastomas2
2TerminatedTreatmentNon-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentRecurrent Melanoma / Stage IV Melanoma1
2TerminatedTreatmentRenal Cell Adenocarcinoma1
2Unknown StatusTreatmentLung Cancers1
2Unknown StatusTreatmentMelanoma (Skin)1
2Unknown StatusTreatmentMetastatic Renal Cell Carcinoma1
2Unknown StatusTreatmentNeuroblastomas1
2Unknown StatusTreatmentRenal Cancers9
2WithdrawnTreatmentAcute Myelogenous Leukaemia (AML)1
2WithdrawnTreatmentCrohn's Disease (CD)1
2WithdrawnTreatmentMelanoma (Skin)1
2, 3CompletedTreatmentMalignant Lymphomas1
3CompletedTreatmentAdult Acute Basophilic Leukemia / Adult Acute Eosinophilic Leukemia / Adult Acute Erythroid Leukemia (M6) / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Childhood Acute Basophilic Leukemia / Childhood Acute Eosinophilic Leukemia / Childhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Minimally Differentiated Myeloid Leukemia (M0) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / De Novo Myelodysplastic Syndromes / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentChildhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Anemia With Ringed Sideroblasts / Secondary Myelodysplastic Syndromes / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3CompletedTreatmentDisseminated Neuroblastoma / Localized Resectable Neuroblastoma / Localized Unresectable Neuroblastoma / Regional Neuroblastoma / Stage 4 Neuroblastoma / Stage 4S Neuroblastoma1
3CompletedTreatmentGraft Versus Host Disease (GVHD) / Malignant Lymphomas1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections4
3CompletedTreatmentLeukemias2
3CompletedTreatmentLocalized Resectable Neuroblastoma / Localized Unresectable Neuroblastoma / Recurrent Neuroblastoma / Regional Neuroblastoma / Stage 4 Neuroblastoma / Stage 4S Neuroblastoma1
3CompletedTreatmentMelanoma (Skin)2
3CompletedTreatmentMelanoma / Skin Cancers1
3CompletedTreatmentRecurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma1
3CompletedTreatmentRecurrent Melanoma / Stage IIIA Skin Melanoma / Stage IIIB Skin Melanoma / Stage IIIC Skin Melanoma / Stage IV Skin Melanoma1
3CompletedTreatmentRenal Cancers6
3Not Yet RecruitingTreatmentChildhood Ganglioneuroblastoma / Childhood Neuroblastoma / NMYC Gene Amplification / Recurrent Neuroblastoma1
3RecruitingTreatmentMetastatic Melanoma1
3RecruitingTreatmentNeuroblastomas1
3Unknown StatusTreatmentHead and Neck Carcinoma1
3Unknown StatusTreatmentLeukemias2
3Unknown StatusTreatmentMelanoma (Skin) / Metastatic Cancers1
4CompletedTreatmentLeukemia Acute Myeloid Leukemia (AML)1
4CompletedTreatmentRenal Cancers1
4Not Yet RecruitingTreatmentLiver Diseases / Transplantations1
4TerminatedTreatmentMetastatic Melanoma1
Not AvailableActive Not RecruitingNot AvailableMalignant Melanoma1
Not AvailableActive Not RecruitingTreatmentMetastatic Melanoma2
Not AvailableCompletedNot AvailableHead and Neck Carcinoma1
Not AvailableCompletedTreatmentChronic Hepatitis C Infection / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections5
Not AvailableRecruitingTreatmentAdult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia1
Not AvailableRecruitingTreatmentHLA-A2 Positive Cells Present / Metastatic Malignant Neoplasm / Metastatic Malignant Neoplasm in the Brain1
Not AvailableTerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableUnknown StatusTreatmentMelanoma (Skin) / Renal Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Dosage forms
FormRouteStrength
InjectionIntravenous1.1 mg/mL
Injection, powder, lyophilized, for solutionIntravenous1.1 mg/mL
Powder, for solutionIntravenous22000000 unit
Prices
Unit descriptionCostUnit
Proleukin 22 million unit vial1092.34USD each
Proleukin 22000000 unit Solution Vial976.66USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
hydrophobicity-0.192Not Available
isoelectric point7.31Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
Modulator
General Function
Interleukin-2 receptor activity
Specific Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Gene Name
IL2RB
Uniprot ID
P14784
Uniprot Name
Interleukin-2 receptor subunit beta
Molecular Weight
61116.59 Da
References
  1. Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13. [PubMed:16477002]
  2. Steppan S, Eckart MR, Bajsarowicz K, Sternberg LR, Greve JM, Cassell DJ: Reduced secondary cytokine induction by BAY 50-4798, a high-affinity receptor-specific interleukin-2 analog. J Interferon Cytokine Res. 2006 Mar;26(3):171-8. [PubMed:16542139]
  3. Cornish GH, Sinclair LV, Cantrell DA: Differential regulation of T-cell growth by IL-2 and IL-15. Blood. 2006 Jul 15;108(2):600-8. Epub 2006 Mar 28. [PubMed:16569767]
  4. Lee KD, Chen HW, Chen CC, Shih YC, Liu HK, Cheng ML: Construction and characterization of a novel fusion protein consisting of anti-CD3 antibody fused to recombinant interleukin-2. Oncol Rep. 2006 May;15(5):1211-6. [PubMed:16596189]
  5. Maclennan C, Hutchinson P, Holdsworth S, Bardin PG, Freezer NJ: Airway inflammation in asymptomatic children with episodic wheeze. Pediatr Pulmonol. 2006 Jun;41(6):577-83. [PubMed:16617454]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
Modulator
General Function
Interleukin-2 receptor activity
Specific Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autorea...
Gene Name
IL2RA
Uniprot ID
P01589
Uniprot Name
Interleukin-2 receptor subunit alpha
Molecular Weight
30818.915 Da
References
  1. Waldmann TA: Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey. J Clin Immunol. 2007 Jan;27(1):1-18. Epub 2007 Jan 11. [PubMed:17216565]
  2. Recchia F, Cesta A, Rea S: Low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy. J Exp Clin Cancer Res. 2003 Dec;22(4 Suppl):135-43. [PubMed:16767920]
  3. Waldmann TA: Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma. Oncogene. 2007 May 28;26(25):3699-703. [PubMed:17530023]
  4. Vlad G, Ho EK, Vasilescu ER, Fan J, Liu Z, Cai JW, Jin Z, Burke E, Deng M, Cadeiras M, Cortesini R, Itescu S, Marboe C, Mancini D, Suciu-Foca N: Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl Immunol. 2007 Jul;18(1):13-21. Epub 2007 Apr 2. [PubMed:17584597]
  5. Liu BY, Zhu P, Luo HB, Fu N: [Screening of short peptides binding to cell surface interleukin-2 receptor alpha chain]. Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jul;26(7):971-4. [PubMed:16864089]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Ouyang Y, Kaminski NE: Phospholipase A2 inhibitors p-bromophenacyl bromide and arachidonyl trifluoromethyl ketone suppressed interleukin-2 (IL-2) expression in murine primary splenocytes. Arch Toxicol. 1999 Feb;73(1):1-6. [PubMed:10207608]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Interleukin-2 binding
Specific Function
Common subunit for the receptors for a variety of interleukins.
Gene Name
IL2RG
Uniprot ID
P31785
Uniprot Name
Cytokine receptor common subunit gamma
Molecular Weight
42286.68 Da
References
  1. Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13. [PubMed:16477002]
  2. Shibata F, Toma T, Wada T, Inoue M, Tone Y, Ohta K, Kasahara Y, Sano F, Kimura M, Ikeno M, Koizumi S, Yachie A: Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. Eur J Haematol. 2007 Jul;79(1):81-5. [PubMed:17598841]
  3. Fonseca SG, Reis MM, Coelho V, Nogueira LG, Monteiro SM, Mairena EC, Bacal F, Bocchi E, Guilherme L, Zheng XX, Liew FY, Higuchi ML, Kalil J, Cunha-Neto E: Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy. Scand J Immunol. 2007 Aug-Sep;66(2-3):362-71. [PubMed:17635814]
  4. Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ: The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 1;194(11):1609-16. Epub 2006 Oct 23. [PubMed:17083048]
  5. Smyth CM, Ginn SL, Deakin CT, Logan GJ, Alexander IE: Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood. 2007 Jul 1;110(1):91-8. Epub 2007 Mar 15. [PubMed:17363735]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Pyeon D, Diaz FJ, Splitter GA: Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. J Virol. 2000 Jun;74(12):5740-5. [PubMed:10823885]
  2. Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ: Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. J Immunol. 2008 Feb 1;180(3):1843-53. [PubMed:18209082]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Phospholipase a2 activity
Specific Function
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory...
Gene Name
PLA2G4A
Uniprot ID
P47712
Uniprot Name
Cytosolic phospholipase A2
Molecular Weight
85238.2 Da
References
  1. Wolbink GJ, Schalkwijk C, Baars JW, Wagstaff J, van den Bosch H, Hack CE: Therapy with interleukin-2 induces the systemic release of phospholipase-A2. Cancer Immunol Immunother. 1995 Nov;41(5):287-92. [PubMed:8536274]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Elkahwaji J, Robin MA, Berson A, Tinel M, Letteron P, Labbe G, Beaune P, Elias D, Rougier P, Escudier B, Duvillard P, Pessayre D: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol. 1999 Apr 15;57(8):951-4. [PubMed:10086330]
  2. Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD: Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos. 2004 Mar;32(3):359-63. [PubMed:14977871]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Xanthine oxidase activity
Specific Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Ha...
Gene Name
XDH
Uniprot ID
P47989
Uniprot Name
Xanthine dehydrogenase/oxidase
Molecular Weight
146422.99 Da
References
  1. Faggioni R, Allavena P, Cantoni L, Carelli M, Demitri MT, Delgado R, Gatti S, Gnocchi P, Isetta AM, Paganin C, et al.: Mechanisms of interleukin-2-induced hydrothoraxy in mice: protective effect of endotoxin tolerance and dexamethasone and possible role of reactive oxygen intermediates. J Immunother Emphasis Tumor Immunol. 1994 Apr;15(3):194-201. [PubMed:8032542]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Elkahwaji J, Robin MA, Berson A, Tinel M, Letteron P, Labbe G, Beaune P, Elias D, Rougier P, Escudier B, Duvillard P, Pessayre D: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol. 1999 Apr 15;57(8):951-4. [PubMed:10086330]

Drug created on June 13, 2005 07:24 / Updated on January 14, 2018 10:04