Cushing's Disease

Also known as: Cushings Disease / Cushing Disease / Overproduction of pituitary ACTH / Pituitary ACTH Hypersecretion / Pituitary-dependent Cushing's syndrome

DrugDrug NameDrug Description
DB00434CyproheptadineA serotonin and histamine antagonist used in the treatment of allergy symptoms and in combination with epinephrine in the treatment of anaphylaxis.
DB11837OsilodrostatAn oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism.
DB06663PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
DrugDrug NameTargetType
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB11837OsilodrostatCytochrome P450 11B1, mitochondrialtarget
DB11837OsilodrostatCytochrome P450 11B2, mitochondrialtarget
DB11837OsilodrostatCytochrome P450 3A4enzyme
DB11837OsilodrostatCytochrome P450 2B6enzyme
DB11837OsilodrostatCytochrome P450 2D6enzyme
DB11837OsilodrostatUDP-glucuronosyltransferase 1-4enzyme
DB11837OsilodrostatUDP-glucuronosyltransferase 2B7enzyme
DB11837OsilodrostatUDP-glucuronosyltransferase 2B10enzyme
DB11837OsilodrostatCytochrome P450 3A5enzyme
DB11837OsilodrostatCytochrome P450 1A2enzyme
DB11837OsilodrostatCytochrome P450 2C19enzyme
DB11837OsilodrostatCytochrome P450 2E1enzyme
DB11837OsilodrostatUDP-glucuronosyltransferase 1A1enzyme
DB11837OsilodrostatSolute carrier organic anion transporter family member 1B1transporter
DB11837OsilodrostatSolute carrier family 22 member 1transporter
DB11837OsilodrostatSolute carrier family 22 member 2transporter
DB11837OsilodrostatSolute carrier family 22 member 6transporter
DB11837OsilodrostatSolute carrier family 22 member 8transporter
DB11837OsilodrostatMultidrug and toxin extrusion protein 1transporter
DB06663PasireotideSomatostatin receptor type 1target
DB06663PasireotideSomatostatin receptor type 2target
DB06663PasireotideSomatostatin receptor type 3target
DB06663PasireotideSomatostatin receptor type 5target
DB06663PasireotideCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00307Bexarotene1 / 2Unknown Status1
DB00248Cabergoline2Completed1
DB00317Gefitinib2Recruiting1
DB11837Osilodrostat2Completed1
DB11837Osilodrostat2Recruiting1
DB06663Pasireotide2Completed2
DB00412Rosiglitazone2Terminated1
DB06195Seliciclib2Recruiting1
DB06195Seliciclib2Terminated1
DB02546Vorinostat2Recruiting1
DB00248Cabergoline3Completed1
DB05667Levoketoconazole3Recruiting1
DB00834Mifepristone3Completed1
DB00834Mifepristone3Withdrawn1
DB11837Osilodrostat3Active Not Recruiting1
DB11837Osilodrostat3Completed1
DB06663Pasireotide3Completed3
DB00248Cabergoline4Recruiting1
DB06655Liraglutide4Completed1
DB00331Metformin4Completed1
DB06663Pasireotide4Completed2
DB06663Pasireotide4Recruiting1
DB01261Sitagliptin4Completed1
DB06663PasireotideNot AvailableRecruiting1