Anginal Pain

Also known as: Angina / Ischemic chest pain / Anginal syndrome / Stenocardia / Angina equivalent / Anginal discomfort / Angina syndrome / Ischaemic chest pain / Angina Pectoris

DrugDrug NameDrug Description
DB01076AtorvastatinAtorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels.
DB00343DiltiazemA benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic.
DB00373TimololA beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor.
DB13910Valproate bismuthValproate bismuth is available in Canada in the over-the-counter medication Neo-Laryngobis.
DrugDrug NameTargetType
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinMultidrug resistance protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB00343DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DB00343DiltiazemCytochrome P450 3A4enzyme
DB00343DiltiazemCytochrome P450 2C19enzyme
DB00343DiltiazemCytochrome P450 2D6enzyme
DB00343DiltiazemCytochrome P450 3A5enzyme
DB00343DiltiazemCytochrome P450 3A7enzyme
DB00343DiltiazemMultidrug resistance protein 1transporter
DB00343DiltiazemCytochrome P450 2C8enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DrugDrug NamePhaseStatusCount
DB00841Dobutamine0Terminated1
DB06213Regadenoson0Terminated1
DB00335Atenolol1Completed1
DB04854Febuxostat2Terminated1
DB00062Human Serum Albumin2Completed1
DB09337Medical air2Completed1
DB09152Nitrogen2Completed1
DB09140Oxygen2Completed1
DB00243Ranolazine2Completed1
DB00243Ranolazine2Terminated1
DB00243Ranolazine3Completed3
DB00945Acetylsalicylic acid4Not Yet Recruiting1
DB00381Amlodipine4Completed1
DB01076Atorvastatin4Completed1
DB01136Carvedilol4Unknown Status1
DB00187Esmolol4Terminated1
DB09083Ivabradine4Unknown Status1
DB09083Ivabradine4Withdrawn1
DB00281Lidocaine4Recruiting1
DB00264Metoprolol4Terminated1
DB00727Nitroglycerin4Recruiting1
DB08860Pitavastatin4Active Not Recruiting1
DB00243Ranolazine4Recruiting1
DB00243Ranolazine4Unknown Status1
DB00243Ranolazine4Withdrawn1
DB01109HeparinNot AvailableUnknown Status1
DB00243RanolazineNot AvailableNot Yet Recruiting1
DB00243RanolazineNot AvailableUnknown Status1