Identification

Name
Diltiazem
Accession Number
DB00343  (APRD00473)
Type
Small Molecule
Groups
Approved
Description

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem]

Structure
Thumb
Synonyms
  • (+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-5-(2-(dimethylamino)Ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
  • Diltiazem
  • Diltiazemum
Product Ingredients
IngredientUNIICASInChI Key
Diltiazem hydrochlorideOLH94387TE33286-22-5HDRXZJPWHTXQRI-BHDTVMLSSA-N
Diltiazem malate14Y6444DRP144604-00-2IUSFTUWHKCSCDY-QTKZZPNDSA-N
Diltiazem maleate896626Q8XW139492-78-7WHBXLOWLFLTDMD-WECFPGDBSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Diltiazem CDCapsule, extended release120 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release300 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release180 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release240 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release240 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release180 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release300 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release120 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release360 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Alti-diltiazem Tab 30mgTablet30 mgOralAltimed Pharma Inc.1990-12-312005-05-27Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Diltiaz Tab 30mgTablet30 mgOralApotex Corporation1988-12-31Not applicableCanada
Apo Diltiaz Tab 60mgTablet60 mgOralApotex Corporation1988-12-31Not applicableCanada
Apo-diltiaz CDCapsule, extended release180 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CDCapsule, extended release240 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CDCapsule, extended release120 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CD - Cap 300mgCapsule, extended release300 mgOralApotex Corporation1996-09-12Not applicableCanada
Apo-diltiaz InjectableLiquid5 mgIntravenousApotex Corporation2000-06-202013-08-02Canada
Apo-diltiaz SR - 90mg/srcCapsule, extended release90 mgOralApotex Corporation1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 120mgCapsule, extended release120 mgOralApotex Corporation1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 60mgCapsule, extended release60 mgOralApotex Corporation1996-09-19Not applicableCanada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Diltiazem HClInjection, solution1 mg/mLIntravenousCantrell Drug Company2011-09-30Not applicableUs
Diltiazem HClInjection, solution.83 mg/mLIntravenousCantrell Drug Company2013-10-22Not applicableUs
International/Other Brands
Acalix (Roemmers) / Adizem (Mundipharma) / Altiazem (Lusofarmaco) / Anoheal / Calcicard / Cartia / Dilacor / Dilacor-XR (Watson) / Dilcontin (Modi-Mundipharma) / Dilrene (Sanofi) / Diltia XT / Dilticard (Intra) / Dilzem (Pfizer) / Herbesser (Mitsubishi Tanabe) / Incoril AP (Bago) / Masdil (Esteve) / Surazem / TAZTIA / Viazem (Biovail)
Categories
UNII
EE92BBP03H
CAS number
42399-41-7
Weight
Average: 414.518
Monoisotopic: 414.16132802
Chemical Formula
C22H26N2O4S
InChI Key
HSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
SMILES
COC1=CC=C(C=C1)[[email protected]@H]1SC2=CC=CC=C2N(CCN(C)C)C(=O)[[email protected]@H]1OC(C)=O

Pharmacology

Indication

For the treatment of Hypertension

Structured Indications
Pharmacodynamics

Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is a non-dihydropyridine (DHP)member of the calcium channel blocker class, along with Verapamil. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Mechanism of action

Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

TargetActionsOrganism
AVoltage-dependent calcium channel gamma-1 subunit
inhibitor
Human
Absorption

Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Volume of distribution
Not Available
Protein binding

70%-80%

Metabolism

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

Route of elimination
Not Available
Half life

3.0 - 4.5 hours

Clearance
Not Available
Toxicity

LD50=740mg/kg (orally in mice)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Diltiazem Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Beta-1 adrenergic receptor---(G;G) / (C;G)---Effect Directly StudiedPatients with this genotype require a lower dosage of diltiazem to achieve a favourable rate-control response when treating atrial fibrillation.Details

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe metabolism of Diltiazem can be decreased when combined with 1,10-Phenanthroline.Experimental
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Diltiazem.Experimental
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Diltiazem.Vet Approved
3,4-DichloroisocoumarinThe metabolism of Diltiazem can be decreased when combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-Aminoethyl)Benzenesulfonyl FluorideThe metabolism of Diltiazem can be decreased when combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Diltiazem.Experimental
AbirateroneThe serum concentration of Diltiazem can be increased when it is combined with Abiraterone.Approved
AcebutololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Acebutolol.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Diltiazem.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Diltiazem.Approved
AcetyldigitoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Acetyldigitoxin.Approved
AcetyldigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Acetyldigoxin.Experimental
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Diltiazem.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Diltiazem.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Diltiazem.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Diltiazem.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Diltiazem.Approved
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Diltiazem.Approved
AldosteroneThe serum concentration of Diltiazem can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Diltiazem can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Diltiazem.Approved, Illicit
AlfuzosinAlfuzosin may increase the hypotensive activities of Diltiazem.Approved, Investigational
AliskirenThe risk or severity of adverse effects can be increased when Diltiazem is combined with Aliskiren.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Diltiazem.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Diltiazem.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Diltiazem.Approved, Investigational
AlogliptinThe metabolism of Diltiazem can be decreased when combined with Alogliptin.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Diltiazem.Approved, Withdrawn
AloxiprinDiltiazem may increase the anticoagulant activities of Aloxiprin.Experimental
Alpha-1-proteinase inhibitorThe metabolism of Diltiazem can be decreased when combined with Alpha-1-proteinase inhibitor.Approved
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
AlprenololDiltiazem may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmantadineThe serum concentration of Diltiazem can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Diltiazem.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Diltiazem.Approved
AmifostineDiltiazem may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amiloride.Approved
Aminohippuric acidThe serum concentration of Diltiazem can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Diltiazem.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Diltiazem.Approved
Aminosalicylic AcidDiltiazem may increase the anticoagulant activities of Aminosalicylic Acid.Approved
AmiodaroneDiltiazem may increase the bradycardic activities of Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Diltiazem.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amlodipine.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Diltiazem.Approved, Illicit
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Diltiazem.Approved
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Diltiazem.Approved, Investigational
AmprenavirThe metabolism of Diltiazem can be decreased when combined with Amprenavir.Approved
AmsacrineThe serum concentration of Diltiazem can be increased when it is combined with Amsacrine.Approved
Amyl NitriteThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amyl Nitrite.Approved
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Diltiazem.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Diltiazem.Approved
Antithrombin III humanThe metabolism of Diltiazem can be decreased when combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Diltiazem.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Diltiazem.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Apraclonidine.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Diltiazem.Approved, Investigational
AprepitantThe serum concentration of Diltiazem can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe metabolism of Diltiazem can be decreased when combined with Aprotinin.Approved, Withdrawn
ArgatrobanThe metabolism of Diltiazem can be decreased when combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Diltiazem.Approved, Investigational
ArmodafinilThe metabolism of Diltiazem can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Diltiazem.Approved
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Diltiazem.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Diltiazem.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Diltiazem.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Diltiazem.Approved, Withdrawn
AsunaprevirThe metabolism of Diltiazem can be decreased when combined with Asunaprevir.Approved, Investigational
AtazanavirThe metabolism of Diltiazem can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe risk or severity of adverse effects can be increased when Atenolol is combined with Diltiazem.Approved
AtomoxetineThe metabolism of Diltiazem can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Diltiazem can be increased when it is combined with Atorvastatin.Approved
AtosibanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Atosiban.Approved
Atracurium besylateDiltiazem may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Diltiazem.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Diltiazem.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Diltiazem.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Azilsartan medoxomil.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Diltiazem.Approved
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Diltiazem.Experimental
BalsalazideDiltiazem may increase the anticoagulant activities of Balsalazide.Approved, Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Diltiazem.Investigational
BarbexacloneBarbexaclone may increase the hypotensive activities of Diltiazem.Experimental
BarbitalBarbital may increase the hypotensive activities of Diltiazem.Illicit
BarnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Diltiazem.Approved
BatimastatThe metabolism of Diltiazem can be decreased when combined with Batimastat.Experimental
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Diltiazem.Approved
BefunololDiltiazem may increase the hypotensive activities of Befunolol.Experimental
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Diltiazem.Approved, Investigational
BenazeprilThe metabolism of Diltiazem can be decreased when combined with Benazepril.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Diltiazem.Withdrawn
BenzamidineThe metabolism of Diltiazem can be decreased when combined with Benzamidine.Experimental
BenzocaineThe serum concentration of Diltiazem can be increased when it is combined with Benzocaine.Approved
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Diltiazem.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Diltiazem.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Diltiazem.Approved
BepridilThe serum concentration of Diltiazem can be increased when it is combined with Bepridil.Approved, Withdrawn
BeractantDiltiazem may increase the bradycardic activities of Beractant.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Diltiazem.Approved, Vet Approved
BetaxololThe risk or severity of adverse effects can be increased when Betaxolol is combined with Diltiazem.Approved
BethanidineBethanidine may increase the hypotensive activities of Diltiazem.Approved
BevantololDiltiazem may increase the hypotensive activities of Bevantolol.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Diltiazem.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Diltiazem.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Diltiazem.Approved
BietaserpineBietaserpine may increase the hypotensive activities of Diltiazem.Experimental
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Diltiazem.Approved
BimatoprostDiltiazem may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BiperidenThe serum concentration of Diltiazem can be increased when it is combined with Biperiden.Approved
BisoprololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Bisoprolol.Approved
BivalirudinThe metabolism of Diltiazem can be decreased when combined with Bivalirudin.Approved, Investigational
BoceprevirThe metabolism of Diltiazem can be decreased when combined with Boceprevir.Withdrawn
BopindololDiltiazem may increase the hypotensive activities of Bopindolol.Approved
BortezomibThe metabolism of Diltiazem can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Diltiazem.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Diltiazem.Approved
BQ-123Diltiazem may increase the hypotensive activities of BQ-123.Investigational
Brefeldin AThe risk or severity of adverse effects can be increased when 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE is combined with Diltiazem.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Diltiazem.Approved
BretyliumBretylium may increase the bradycardic activities of Diltiazem.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Diltiazem.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Diltiazem.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Diltiazem.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Diltiazem.Approved, Investigational
BrofaromineBrofaromine may increase the hypotensive activities of Diltiazem.Experimental
BromazepamThe metabolism of Bromazepam can be decreased when combined with Diltiazem.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Diltiazem.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Diltiazem.Approved
BucindololDiltiazem may increase the hypotensive activities of Bucindolol.Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Diltiazem.Approved
BufuralolDiltiazem may increase the hypotensive activities of Bufuralol.Experimental, Investigational
BumetanideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Bumetanide.Approved
BunazosinBunazosin may increase the hypotensive activities of Diltiazem.Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Diltiazem.Approved, Investigational
BupranololDiltiazem may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Diltiazem can be decreased when combined with Bupropion.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Diltiazem.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Diltiazem.Approved, Investigational
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Diltiazem.Approved
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Diltiazem.Approved
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Diltiazem.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Diltiazem.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Diltiazem.Approved
CadralazineCadralazine may increase the hypotensive activities of Diltiazem.Experimental
CafedrineDiltiazem may increase the hypotensive activities of Cafedrine.Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Diltiazem.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Diltiazem.Approved, Nutraceutical
CalciumThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium.Nutraceutical
Calcium AcetateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Acetate.Approved
Calcium CarbonateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Carbonate.Approved
Calcium CitrateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium lactate.Approved, Experimental, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium laevulateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium laevulate.Experimental
Calcium pangamateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Phosphate.Approved
CalfactantDiltiazem may increase the bradycardic activities of Calfactant.Approved
CamostatThe metabolism of Diltiazem can be decreased when combined with Camostat.Experimental
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Diltiazem.Experimental
CanagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Canagliflozin.Approved
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Candesartan.Approved
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Diltiazem.Withdrawn
CandoxatrilThe metabolism of Diltiazem can be decreased when combined with Candoxatril.Experimental
CandoxatrilatThe metabolism of Diltiazem can be decreased when combined with Candoxatrilat.Experimental
CapecitabineThe metabolism of Diltiazem can be decreased when combined with Capecitabine.Approved, Investigational
Capric acidThe risk or severity of adverse effects can be increased when Capric acid is combined with Diltiazem.Experimental
CaptoprilThe metabolism of Diltiazem can be decreased when combined with Captopril.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Diltiazem.Approved, Investigational
Carbaspirin calciumDiltiazem may increase the anticoagulant activities of Carbaspirin calcium.Experimental
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Diltiazem.Approved
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Diltiazem.Approved
CarbomycinThe metabolism of Diltiazem can be decreased when combined with Carbomycin.Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Diltiazem.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Diltiazem.Approved
CaroxazoneCaroxazone may increase the hypotensive activities of Diltiazem.Withdrawn
CarteololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Carteolol.Approved
CarvedilolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Carvedilol.Approved, Investigational
CaseinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Casein.Approved
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Diltiazem.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Diltiazem.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Diltiazem.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Diltiazem.Approved, Vet Approved
CeritinibThe serum concentration of Diltiazem can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Diltiazem.Withdrawn
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Diltiazem.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Diltiazem.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Diltiazem.Approved
ChloramphenicolThe metabolism of Diltiazem can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Diltiazem.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Diltiazem.Approved, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Chlorothiazide.Approved, Vet Approved
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Diltiazem.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Diltiazem.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Diltiazem.Approved, Vet Approved
ChlorpropamideThe serum concentration of Diltiazem can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Diltiazem can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Diltiazem.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Diltiazem.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Diltiazem.Approved, Nutraceutical
CholesterolThe metabolism of Diltiazem can be decreased when combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Diltiazem can be decreased when it is combined with Cholic Acid.Approved
ChymostatinThe metabolism of Diltiazem can be decreased when combined with Chymostatin.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Diltiazem.Approved, Investigational
CicletanineDiltiazem may increase the hypotensive activities of Cicletanine.Investigational
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Diltiazem.Approved, Investigational
CilastatinThe metabolism of Diltiazem can be decreased when combined with Cilastatin.Approved
CilazaprilThe metabolism of Diltiazem can be decreased when combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Diltiazem.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Diltiazem.Approved
CimetidineThe serum concentration of Diltiazem can be increased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Diltiazem can be decreased when combined with Cinacalcet.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Diltiazem.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Diltiazem.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Diltiazem.Approved
ClarithromycinThe metabolism of Diltiazem can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Diltiazem can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Diltiazem.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Diltiazem.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Diltiazem.Approved, Investigational
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Diltiazem.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Diltiazem.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Diltiazem.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Diltiazem.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Diltiazem.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Diltiazem.Approved, Illicit
ClonidineClonidine may increase the atrioventricular blocking (AV block) activities of Diltiazem.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Diltiazem.Approved, Nutraceutical
CloranololDiltiazem may increase the hypotensive activities of Cloranolol.Experimental
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Diltiazem.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Diltiazem.Approved, Illicit
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Diltiazem.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Diltiazem.Approved
CobicistatThe serum concentration of Diltiazem can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Diltiazem.Approved
CocaineThe metabolism of Diltiazem can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Diltiazem.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Diltiazem.Approved
ColestipolColestipol can cause a decrease in the absorption of Diltiazem resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColforsinThe serum concentration of Diltiazem can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Diltiazem can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Diltiazem.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Diltiazem.Approved
CordycepinThe risk or severity of adverse effects can be increased when Cordycepin is combined with Diltiazem.Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Diltiazem.Approved
CrisaboroleThe metabolism of Diltiazem can be decreased when combined with Crisaborole.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Diltiazem.Approved
CryptenamineDiltiazem may increase the hypotensive activities of Cryptenamine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Diltiazem.Approved
CyclopenthiazideDiltiazem may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Diltiazem.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
CyclothiazideDiltiazem may increase the hypotensive activities of Cyclothiazide.Approved
CymarinDiltiazem may increase the atrioventricular blocking (AV block) activities of Cymarin.Experimental
CytarabineThe metabolism of Cytarabine can be decreased when combined with Diltiazem.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Diltiazem.Approved
DabrafenibThe serum concentration of Diltiazem can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Diltiazem.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Diltiazem.Approved
DantroleneDantrolene may increase the hyperkalemic activities of Diltiazem.Approved
DapagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dapagliflozin.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Diltiazem.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Diltiazem.Approved, Investigational
DarexabanThe metabolism of Diltiazem can be decreased when combined with Darexaban.Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Diltiazem.Approved, Investigational
DarunavirThe serum concentration of Diltiazem can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Diltiazem.Approved
DasatinibThe serum concentration of Diltiazem can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Diltiazem.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Diltiazem.Approved
DeferasiroxThe serum concentration of Diltiazem can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Diltiazem.Approved
DelanzomibThe metabolism of Diltiazem can be decreased when combined with Delanzomib.Investigational
DelaprilThe metabolism of Diltiazem can be decreased when combined with Delapril.Experimental
DelavirdineThe metabolism of Diltiazem can be decreased when combined with Delavirdine.Approved
dersalazineDiltiazem may increase the anticoagulant activities of dersalazine.Investigational
DeserpidineDiltiazem may increase the hypotensive activities of Deserpidine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Diltiazem.Approved
DesipramineThe serum concentration of Diltiazem can be increased when it is combined with Desipramine.Approved
DeslanosideDiltiazem may increase the atrioventricular blocking (AV block) activities of Deslanoside.Approved
DesloratadineThe serum concentration of Diltiazem can be increased when it is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Diltiazem.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Diltiazem.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Diltiazem.Approved
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Diltiazem.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dexmedetomidine.Approved, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Diltiazem.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Diltiazem.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Diltiazem.Approved, Illicit, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Diltiazem.Approved
DichloropheneThe risk or severity of adverse effects can be increased when Dichlorophene is combined with Diltiazem.Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Diltiazem.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Diclofenamide.Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Diltiazem.Approved
diethylnorspermineDiltiazem may increase the hypotensive activities of diethylnorspermine.Investigational
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Diltiazem.Approved
DiflunisalDiltiazem may increase the anticoagulant activities of Diflunisal.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Diltiazem.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Diltiazem.Approved
DihydralazineDihydralazine may increase the hypotensive activities of Diltiazem.Investigational
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Diltiazem.Approved, Illicit
DihydroergotamineThe metabolism of Diltiazem can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Diltiazem.Illicit
DinutuximabThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dinutuximab.Approved
DiphenhydramineThe metabolism of Diltiazem can be decreased when combined with Diphenhydramine.Approved
DipyridamoleThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dipyridamole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Diltiazem.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Diltiazem.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Diltiazem.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Diltiazem.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Diltiazem.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Diltiazem.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Diltiazem.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Diltiazem.Approved
DosulepinThe metabolism of Diltiazem can be decreased when combined with Dosulepin.Approved
DoxazosinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Diltiazem.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Diltiazem.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Diltiazem.Approved, Investigational
DoxycyclineThe metabolism of Diltiazem can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.Approved, Illicit
DronedaroneDiltiazem may increase the atrioventricular blocking (AV block) activities of Dronedarone.Approved
DuloxetineDiltiazem may increase the orthostatic hypotensive activities of Duloxetine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Diltiazem.Approved, Investigational
EcabetThe metabolism of Diltiazem can be decreased when combined with Ecabet.Approved, Investigational
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Diltiazem.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Diltiazem.Approved
EfavirenzThe serum concentration of Diltiazem can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Diltiazem.Approved
EfonidipineDiltiazem may increase the hypotensive activities of Efonidipine.Approved
ElafinThe metabolism of Diltiazem can be decreased when combined with Elafin.Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Diltiazem.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Diltiazem.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Diltiazem.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Diltiazem.Approved
EmpagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Empagliflozin.Approved
EnalaprilThe metabolism of Diltiazem can be decreased when combined with Enalapril.Approved, Vet Approved
EnalaprilatThe metabolism of Diltiazem can be decreased when combined with Enalaprilat.Approved
EnalkirenThe metabolism of Diltiazem can be decreased when combined with Enalkiren.Experimental
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Diltiazem.Approved
EndralazineEndralazine may increase the hypotensive activities of Diltiazem.Experimental
EnzalutamideThe serum concentration of Diltiazem can be decreased when it is combined with Enzalutamide.Approved
EpanololDiltiazem may increase the hypotensive activities of Epanolol.Experimental
Epigallocatechin GallateThe metabolism of Diltiazem can be decreased when combined with Epigallocatechin Gallate.Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Diltiazem.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Diltiazem.Approved
EpoprostenolDiltiazem may increase the hypotensive activities of Epoprostenol.Approved
EprosartanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Eprosartan.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Diltiazem.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Diltiazem.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Diltiazem.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Diltiazem.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Diltiazem.Approved, Investigational
ErythromycinThe metabolism of Diltiazem can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Diltiazem.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Diltiazem can be decreased when combined with Eslicarbazepine acetate.Approved
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Diltiazem.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Diltiazem.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Diltiazem.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Diltiazem.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Diltiazem.Approved
EstriolThe serum concentration of Diltiazem can be decreased when it is combined with Estriol.Approved, Vet Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Diltiazem.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Diltiazem.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Diltiazem.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Diltiazem.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Diltiazem is combined with Etacrynic acid.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Diltiazem.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Diltiazem.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Diltiazem.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Diltiazem.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Diltiazem.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Diltiazem.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Diltiazem.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Diltiazem.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Diltiazem.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Diltiazem.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Diltiazem.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Diltiazem.Approved
FaldaprevirThe metabolism of Diltiazem can be decreased when combined with Faldaprevir.Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Diltiazem.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Diltiazem.Approved
FelodipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Felodipine.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Diltiazem.Approved
FenoldopamDiltiazem may increase the hypotensive activities of Fenoldopam.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Diltiazem.Approved, Illicit, Investigational, Vet Approved
FenticonazoleThe risk or severity of adverse effects can be increased when Fenticonazole is combined with Diltiazem.Experimental
Ferulic acidDiltiazem may increase the hypotensive activities of Ferulic acid.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diltiazem.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Diltiazem.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Diltiazem.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Diltiazem.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Diltiazem.Approved
FingolimodDiltiazem may increase the bradycardic activities of Fingolimod.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Diltiazem.Approved
FloxuridineThe metabolism of Diltiazem can be decreased when combined with Floxuridine.Approved
FluconazoleThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.Approved
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Diltiazem.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Diltiazem.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Diltiazem.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Diltiazem.Approved
FluorouracilThe metabolism of Diltiazem can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Diltiazem can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Diltiazem can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Diltiazem can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Diltiazem.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Diltiazem.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Diltiazem.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be decreased when combined with Diltiazem.Approved
FlutrimazoleThe risk or severity of adverse effects can be increased when Flutrimazole is combined with Diltiazem.Experimental
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Diltiazem.Approved
FluvoxamineThe metabolism of Diltiazem can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Diltiazem can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Diltiazem can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe metabolism of Diltiazem can be decreased when combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Diltiazem.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Diltiazem.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.Approved
GabexateThe metabolism of Diltiazem can be decreased when combined with Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Diltiazem.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Diltiazem.Approved, Investigational
GeldanamycinThe metabolism of Diltiazem can be decreased when combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Diltiazem.Approved
GemfibrozilThe metabolism of Diltiazem can be decreased when combined with Gemfibrozil.Approved
GenisteinThe serum concentration of Diltiazem can be increased when it is combined with Genistein.Investigational
GitoformateDiltiazem may increase the atrioventricular blocking (AV block) activities of Gitoformate.Experimental
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Diltiazem.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Diltiazem.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Diltiazem.Approved
GlycerinThe serum concentration of Diltiazem can be increased when it is combined with Glycerin.Approved, Investigational
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Diltiazem.Experimental
GM6001The metabolism of Diltiazem can be decreased when combined with GM6001.Experimental
Gramicidin DThe serum concentration of Diltiazem can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Diltiazem.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Diltiazem.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Diltiazem.Withdrawn
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Diltiazem.Approved, Vet Approved
GuacetisalDiltiazem may increase the anticoagulant activities of Guacetisal.Experimental
GuanabenzDiltiazem may increase the hypotensive activities of Guanabenz.Approved
GuanadrelGuanadrel may increase the hypotensive activities of Diltiazem.Approved
GuanazodineDiltiazem may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineGuanethidine may increase the hypotensive activities of Diltiazem.Approved
GuanfacineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Guanfacine.Approved, Investigational
GuanoclorDiltiazem may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzDiltiazem may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanDiltiazem may increase the hypotensive activities of Guanoxan.Experimental
HachimycinThe risk or severity of adverse effects can be increased when Hachimycin is combined with Diltiazem.Experimental
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Diltiazem.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Diltiazem.Approved
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Diltiazem.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be decreased when combined with Diltiazem.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Diltiazem.Experimental
Hemoglobin crosfumarilDiltiazem may increase the anticoagulant activities of Hemoglobin crosfumaril.Experimental
HexamethoniumDiltiazem may increase the hypotensive activities of Hexamethonium.Experimental
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Diltiazem.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Diltiazem.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Diltiazem.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Diltiazem.Experimental
HydralazineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Hydralazine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Diltiazem.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Diltiazem.Approved, Vet Approved
HydroflumethiazideDiltiazem may increase the hypotensive activities of Hydroflumethiazide.Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Diltiazem.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Diltiazem.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Diltiazem.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Diltiazem.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Diltiazem.Approved, Investigational
IdelalisibThe serum concentration of Diltiazem can be increased when it is combined with Idelalisib.Approved
IdraparinuxThe metabolism of Diltiazem can be decreased when combined with Idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Diltiazem resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Diltiazem.Approved
IloprostIloprost may increase the hypotensive activities of Diltiazem.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Diltiazem.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Diltiazem.Approved
ImidaprilThe metabolism of Diltiazem can be decreased when combined with Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Diltiazem.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Diltiazem.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Diltiazem.Approved
IndapamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Indapamide.Approved
IndenololDiltiazem may increase the hypotensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Diltiazem can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Diltiazem.Approved, Investigational
IndoraminIndoramin may increase the hypotensive activities of Diltiazem.Withdrawn
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Diltiazem.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Diltiazem.Approved
IproclozideIproclozide may increase the hypotensive activities of Diltiazem.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Diltiazem.Withdrawn
IrbesartanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Irbesartan.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Diltiazem.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Diltiazem.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Diltiazem.Approved
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Diltiazem.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Diltiazem.Approved, Vet Approved
IsoflurophateThe metabolism of Diltiazem can be decreased when combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Diltiazem can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isosorbide Dinitrate.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe risk or severity of adverse effects can be increased when Isradipine is combined with Diltiazem.Approved
ItraconazoleThe metabolism of Diltiazem can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineDiltiazem may increase the bradycardic activities of Ivabradine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Diltiazem.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Diltiazem.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Diltiazem.Approved, Investigational
IxazomibThe metabolism of Diltiazem can be decreased when combined with Ixazomib.Approved
JosamycinThe metabolism of Diltiazem can be decreased when combined with Josamycin.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Diltiazem.Approved, Vet Approved
KetanserinKetanserin may increase the hypotensive activities of Diltiazem.Investigational
KetazolamThe metabolism of Ketazolam can be decreased when combined with Diltiazem.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Diltiazem.Approved
KetoconazoleThe metabolism of Diltiazem can be decreased when combined with Ketoconazole.Approved, Investigational
KitasamycinThe metabolism of Diltiazem can be decreased when combined with Kitasamycin.Experimental
LabetalolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Labetalol.Approved
LacidipineDiltiazem may increase the hypotensive activities of Lacidipine.Approved
LacosamideDiltiazem may increase the atrioventricular blocking (AV block) activities of Lacosamide.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Diltiazem.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Diltiazem.Approved, Investigational
Lanatoside CDiltiazem may increase the atrioventricular blocking (AV block) activities of Lanatoside C.Experimental
LandiololDiltiazem may increase the hypotensive activities of Landiolol.Investigational
LanreotideDiltiazem may increase the bradycardic activities of Lanreotide.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Diltiazem.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Diltiazem.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Diltiazem.Investigational
LatanoprostDiltiazem may increase the hypotensive activities of Latanoprost.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Diltiazem.Approved
LeflunomideThe metabolism of Diltiazem can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Diltiazem.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Diltiazem.Approved
LepirudinThe metabolism of Diltiazem can be decreased when combined with Lepirudin.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Diltiazem.Approved, Investigational
LetaxabanThe metabolism of Diltiazem can be decreased when combined with Letaxaban.Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Diltiazem.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Diltiazem.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Levobunolol.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Diltiazem.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Diltiazem.Approved
LevodopaDiltiazem may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Diltiazem.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Diltiazem.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Diltiazem.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Diltiazem.Approved, Investigational
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Diltiazem.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Diltiazem.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Diltiazem.Approved, Vet Approved
LinagliptinThe metabolism of Diltiazem can be decreased when combined with Linagliptin.Approved
LinsidomineDiltiazem may increase the hypotensive activities of Linsidomine.Experimental
LiothyronineThe serum concentration of Diltiazem can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Diltiazem can be decreased when it is combined with Liotrix.Approved
LisinoprilThe metabolism of Diltiazem can be decreased when combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Diltiazem.Approved
LithiumDiltiazem may increase the neurotoxic activities of Lithium.Approved
LobeglitazoneThe metabolism of Diltiazem can be decreased when combined with Lobeglitazone.Approved
LofexidineDiltiazem may increase the hypotensive activities of Lofexidine.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Diltiazem.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Diltiazem.Approved
LopinavirThe metabolism of Diltiazem can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Diltiazem.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Diltiazem.Approved
LosartanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Losartan.Approved
LovastatinThe serum concentration of Diltiazem can be increased when it is combined with Lovastatin.Approved, Investigational
LucinactantDiltiazem may increase the bradycardic activities of Lucinactant.Approved
LuliconazoleThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Diltiazem can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Diltiazem.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Diltiazem.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Diltiazem.Approved
Magnesium HydroxideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium Hydroxide.Approved
Magnesium oxideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium salicylate.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium Sulfate.Approved, Vet Approved
ManidipineDiltiazem may increase the hypotensive activities of Manidipine.Approved
MannitolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Mannitol.Approved, Investigational
MaprotilineThe serum concentration of Diltiazem can be increased when it is combined with Maprotiline.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Diltiazem.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Diltiazem.Withdrawn
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Diltiazem.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Mecamylamine.Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Diltiazem.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Diltiazem.Approved
Megestrol acetateThe serum concentration of Diltiazem can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelagatranThe metabolism of Diltiazem can be decreased when combined with Melagatran.Experimental
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Diltiazem.Approved, Vet Approved
MepartricinThe risk or severity of adverse effects can be increased when Mepartricin is combined with Diltiazem.Experimental
MepindololDiltiazem may increase the hypotensive activities of Mepindolol.Experimental
MeprobamateThe serum concentration of Diltiazem can be increased when it is combined with Meprobamate.Approved, Illicit
MesalazineDiltiazem may increase the anticoagulant activities of Mesalazine.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Diltiazem.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Diltiazem.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Methazolamide.Approved
MethohexitalMethohexital may increase the hypotensive activities of Diltiazem.Approved
MethoserpidineDiltiazem may increase the hypotensive activities of Methoserpidine.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Diltiazem.Approved
MethotrimeprazineThe metabolism of Diltiazem can be decreased when combined with Methotrimeprazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Diltiazem.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Diltiazem.Approved, Vet Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Diltiazem.Approved
Methyl salicylateThe metabolism of Methyl salicylate can be decreased when combined with Diltiazem.Approved, Vet Approved
MethyldopaThe risk or severity of adverse effects can be increased when Diltiazem is combined with Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Diltiazem.Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Diltiazem.Approved, Investigational
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Diltiazem.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Diltiazem.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Diltiazem.Approved
MetildigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Metildigoxin.Experimental
MetipranololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Metipranolol.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Metolazone.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Diltiazem.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Diltiazem.Approved
MetyrosineDiltiazem may increase the hypotensive activities of Metyrosine.Approved
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Diltiazem.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Diltiazem.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Diltiazem.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Diltiazem.Withdrawn
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Diltiazem.Approved, Investigational
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Diltiazem.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Diltiazem.Approved, Illicit
MidodrineDiltiazem may increase the bradycardic activities of Midodrine.Approved
MidostaurinThe metabolism of Diltiazem can be decreased when combined with Midostaurin.Approved
MifepristoneThe serum concentration of Diltiazem can be increased when it is combined with Mifepristone.Approved, Investigational
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Diltiazem.Approved
MinaprineMinaprine may increase the hypotensive activities of Diltiazem.Approved
MinoxidilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Minoxidil.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Diltiazem.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Diltiazem.Investigational
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Diltiazem.Approved
MitomycinThe serum concentration of Diltiazem can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Diltiazem can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MivacuriumDiltiazem may increase the neuromuscular blocking activities of Mivacurium.Approved
MoclobemideThe metabolism of Diltiazem can be decreased when combined with Moclobemide.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Diltiazem.Approved, Investigational
MoexiprilThe metabolism of Diltiazem can be decreased when combined with Moexipril.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Diltiazem.Approved
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Diltiazem.Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Diltiazem.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Diltiazem.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Diltiazem.Approved
MuzolimineDiltiazem may increase the hypotensive activities of Muzolimine.Experimental
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Diltiazem.Approved, Investigational
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Diltiazem.Experimental
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe metabolism of Diltiazem can be decreased when combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Diltiazem.Approved, Investigational
NadololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nadolol.Approved
NafamostatThe metabolism of Diltiazem can be decreased when combined with Nafamostat.Approved, Investigational
NafcillinThe metabolism of Diltiazem can be increased when combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Diltiazem.Approved
NaftopidilDiltiazem may increase the hypotensive activities of Naftopidil.Investigational
NaloxoneThe metabolism of Naloxone can be decreased when combined with Diltiazem.Approved, Vet Approved
NaltrexoneThe serum concentration of Diltiazem can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Diltiazem can be increased when it is combined with Naringenin.Experimental
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Diltiazem.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Diltiazem.Approved, Investigational
NebivololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nebivolol.Approved, Investigational
NefazodoneThe metabolism of Diltiazem can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Diltiazem can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Diltiazem can be increased when it is combined with Neostigmine.Approved, Vet Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Diltiazem.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Diltiazem can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Diltiazem.Withdrawn
NicardipineThe metabolism of Diltiazem can be decreased when combined with Nicardipine.Approved
NicorandilNicorandil may increase the hypotensive activities of Diltiazem.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Diltiazem.Approved
NifedipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nifedipine.Approved
NifuratelThe risk or severity of adverse effects can be increased when Nifuratel is combined with Diltiazem.Experimental
NiguldipineDiltiazem may increase the hypotensive activities of Niguldipine.Experimental
Nikkomycin ZThe risk or severity of adverse effects can be increased when Nikkomycin Z is combined with Diltiazem.Investigational
NilotinibThe metabolism of Nilotinib can be decreased when combined with Diltiazem.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Diltiazem.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Diltiazem.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Diltiazem.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nisoldipine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Diltiazem.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Diltiazem.Approved
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Diltiazem.Approved
NitroaspirinThe metabolism of Diltiazem can be decreased when combined with Nitroaspirin.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nitroglycerin.Approved, Investigational
NitroprussideDiltiazem may increase the hypotensive activities of Nitroprusside.Approved
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Diltiazem.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Diltiazem.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Diltiazem.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Diltiazem.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Diltiazem.Approved
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Diltiazem.Approved, Vet Approved
ObinutuzumabDiltiazem may increase the hypotensive activities of Obinutuzumab.Approved
OctamoxinOctamoxin may increase the hypotensive activities of Diltiazem.Withdrawn
OctreotideOctreotide may increase the bradycardic activities of Diltiazem.Approved, Investigational
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Diltiazem.Investigational
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Diltiazem.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Diltiazem.Approved
OleandomycinThe metabolism of Diltiazem can be decreased when combined with Oleandomycin.Vet Approved
OleandrinDiltiazem may increase the atrioventricular blocking (AV block) activities of Oleandrin.Experimental
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Diltiazem.Approved, Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Diltiazem.Approved
OlsalazineDiltiazem may increase the anticoagulant activities of Olsalazine.Approved
OmapatrilatThe metabolism of Diltiazem can be decreased when combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Diltiazem.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
OmoconazoleThe risk or severity of adverse effects can be increased when Omoconazole is combined with Diltiazem.Experimental
OndansetronThe metabolism of Ondansetron can be decreased when combined with Diltiazem.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Diltiazem.Approved
OsimertinibThe serum concentration of Diltiazem can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Diltiazem.Approved
OtamixabanThe metabolism of Diltiazem can be decreased when combined with Otamixaban.Investigational
OuabainDiltiazem may increase the atrioventricular blocking (AV block) activities of Ouabain.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Diltiazem.Approved
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Diltiazem.Approved
OxprenololDiltiazem may increase the hypotensive activities of Oxprenolol.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Diltiazem.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Diltiazem can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Diltiazem.Approved, Vet Approved
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Diltiazem.Investigational
PalbociclibThe serum concentration of Diltiazem can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Diltiazem can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Diltiazem.Approved, Investigational
PanobinostatThe serum concentration of Diltiazem can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Diltiazem.Approved
PapaverineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Papaverine.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Diltiazem.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Diltiazem.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Diltiazem.Approved
PargylinePargyline may increase the hypotensive activities of Diltiazem.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Diltiazem.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Diltiazem.Approved
ParoxetineThe metabolism of Diltiazem can be decreased when combined with Paroxetine.Approved, Investigational
PasireotideDiltiazem may increase the bradycardic activities of Pasireotide.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Diltiazem.Approved
Peginterferon alfa-2bThe serum concentration of Diltiazem can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenbutololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Penbutolol.Approved, Investigational
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Diltiazem.Approved
PentobarbitalThe metabolism of Diltiazem can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoliniumDiltiazem may increase the hypotensive activities of Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Diltiazem.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Diltiazem.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Diltiazem.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Diltiazem.Approved
PerindoprilThe metabolism of Diltiazem can be decreased when combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Diltiazem.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Diltiazem.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Diltiazem.Approved
PeruvosideDiltiazem may increase the atrioventricular blocking (AV block) activities of Peruvoside.Experimental
PethidineThe metabolism of Pethidine can be decreased when combined with Diltiazem.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Diltiazem.Withdrawn
PhenelzinePhenelzine may increase the hypotensive activities of Diltiazem.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Diltiazem.Withdrawn
PhenobarbitalThe metabolism of Diltiazem can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Diltiazem.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Diltiazem.Withdrawn
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Diltiazem.Approved
PhentolamineDiltiazem may increase the hypotensive activities of Phentolamine.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Diltiazem.Approved, Vet Approved
PhosphoramidonThe metabolism of Diltiazem can be decreased when combined with Phosphoramidon.Experimental
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Diltiazem.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Diltiazem.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Diltiazem.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Diltiazem.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Diltiazem.Withdrawn
PindololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Pindolol.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Diltiazem.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Diltiazem.Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Diltiazem.Approved
PirlindolePirlindole may increase the hypotensive activities of Diltiazem.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Diltiazem.Approved
PivhydrazinePivhydrazine may increase the hypotensive activities of Diltiazem.Withdrawn
Platelet Activating FactorThe serum concentration of Diltiazem can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Diltiazem.Approved
PolythiazideDiltiazem may increase the hypotensive activities of Polythiazide.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Diltiazem.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Diltiazem.Approved
Poractant alfaDiltiazem may increase the bradycardic activities of Poractant alfa.Approved
PosaconazoleThe metabolism of Diltiazem can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PractololDiltiazem may increase the hypotensive activities of Practolol.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Diltiazem.Approved, Investigational
PrasteroneThe metabolism of Prasterone can be decreased when combined with Diltiazem.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Diltiazem.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Diltiazem.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Diltiazem.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Diltiazem.Approved, Vet Approved
PrazosinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Prazosin.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Diltiazem.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Diltiazem.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Diltiazem.Approved
PrimidoneThe metabolism of Diltiazem can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe metabolism of Diltiazem can be decreased when combined with Prinomastat.Investigational
ProbenecidThe serum concentration of Diltiazem can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Diltiazem.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Diltiazem.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Diltiazem.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Diltiazem.Approved, Vet Approved
PromethazineThe serum concentration of Diltiazem can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Diltiazem.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be decreased when combined with Diltiazem.Approved
PropranololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Propranolol.Approved, Investigational
ProscillaridinDiltiazem may increase the atrioventricular blocking (AV block) activities of Proscillaridin.Experimental
ProtriptylineThe serum concentration of Diltiazem can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Diltiazem.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Diltiazem.Approved
PyrimethamineThe metabolism of Diltiazem can be decreased when combined with Pyrimethamine.Approved, Vet Approved
PyrrolnitrinThe risk or severity of adverse effects can be increased when Pyrrolnitrin is combined with Diltiazem.Experimental
QuazepamThe metabolism of Quazepam can be decreased when combined with Diltiazem.Approved, Illicit
QuercetinThe serum concentration of Diltiazem can be increased when it is combined with Quercetin.Experimental
QuetiapineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Quetiapine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Diltiazem.Approved
QuinaprilThe metabolism of Diltiazem can be decreased when combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Diltiazem.Approved
QuinineQuinine may increase the hypotensive activities of Diltiazem.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Diltiazem.Approved, Investigational
RacecadotrilThe metabolism of Diltiazem can be decreased when combined with Racecadotril.Investigational
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Diltiazem.Experimental
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Diltiazem.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Diltiazem.Approved, Investigational
RamiprilThe metabolism of Diltiazem can be decreased when combined with Ramipril.Approved
RanitidineThe serum concentration of Diltiazem can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.Approved, Investigational
RapacuroniumDiltiazem may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RasagilineRasagiline may increase the hypotensive activities of Diltiazem.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Diltiazem.Approved, Investigational
RegorafenibRegorafenib may increase the bradycardic activities of Diltiazem.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Diltiazem.Approved
RemikirenThe metabolism of Diltiazem can be decreased when combined with Remikiren.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Diltiazem.Approved, Investigational
RescinnamineDiltiazem may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Diltiazem.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Diltiazem.Approved
RifabutinThe metabolism of Diltiazem can be increased when combined with Rifabutin.Approved
RifampicinThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Diltiazem can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Diltiazem.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Diltiazem.Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Diltiazem.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Diltiazem.Approved, Investigational
RiociguatThe risk or severity of adverse effects can be increased when Diltiazem is combined with Riociguat.Approved
RisperidoneDiltiazem may increase the hypotensive activities of Risperidone.Approved, Investigational
RitonavirThe metabolism of Diltiazem can be decreased when combined with Ritonavir.Approved, Investigational
RituximabDiltiazem may increase the hypotensive activities of Rituximab.Approved
RivaroxabanThe metabolism of Diltiazem can be decreased when combined with Rivaroxaban.Approved
RivastigmineDiltiazem may increase the bradycardic activities of Rivastigmine.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Diltiazem.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Diltiazem.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Diltiazem.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Diltiazem.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Diltiazem.Approved
RosiglitazoneThe metabolism of Diltiazem can be decreased when combined with Rosiglitazone.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Diltiazem.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Diltiazem.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Diltiazem.Approved, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Diltiazem.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Diltiazem.Approved
RuxolitinibRuxolitinib may increase the bradycardic activities of Diltiazem.Approved
S-3304The metabolism of Diltiazem can be decreased when combined with S-3304.Investigational
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Diltiazem.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Diltiazem.Approved
SafrazineSafrazine may increase the hypotensive activities of Diltiazem.Withdrawn
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Diltiazem.Experimental
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Diltiazem.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Diltiazem.Approved
SaprisartanDiltiazem may increase the hypotensive activities of Saprisartan.Experimental
SaquinavirThe metabolism of Diltiazem can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Diltiazem.Approved
ScopolamineThe serum concentration of Diltiazem can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Diltiazem can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Diltiazem.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Diltiazem.Approved
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Diltiazem.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Diltiazem.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Diltiazem.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Diltiazem.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Withdrawn
SildenafilSildenafil may increase the antihypertensive activities of Diltiazem.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Diltiazem.Approved
SiltuximabThe serum concentration of Diltiazem can be decreased when it is combined with Siltuximab.Approved
SimvastatinThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.Approved
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Diltiazem.Experimental
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Diltiazem.Approved, Investigational
SitagliptinThe metabolism of Diltiazem can be decreased when combined with Sitagliptin.Approved, Investigational
SitaxentanDiltiazem may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SivelestatThe metabolism of Diltiazem can be decreased when combined with Sivelestat.Investigational
Sodium NitriteThe risk or severity of adverse effects can be increased when Sodium Nitrite is combined with Diltiazem.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Diltiazem.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Diltiazem.Approved
SolithromycinThe metabolism of Diltiazem can be decreased when combined with Solithromycin.Investigational
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Diltiazem.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Diltiazem.Approved, Investigational
SotalolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Diltiazem.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Diltiazem.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Diltiazem.Approved
SpiraprilThe metabolism of Diltiazem can be decreased when combined with Spirapril.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Diltiazem can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Diltiazem can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Diltiazem can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Diltiazem.Approved
StreptozocinThe serum concentration of Diltiazem can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Diltiazem.Approved, Investigational
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Diltiazem.Approved
SulfadiazineThe metabolism of Diltiazem can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Diltiazem.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Diltiazem.Approved
SulfisoxazoleThe metabolism of Diltiazem can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Diltiazem can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Diltiazem.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Diltiazem.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Diltiazem.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Diltiazem.Approved
TacrineThe serum concentration of Diltiazem can be increased when it is combined with Tacrine.Withdrawn
TadalafilTadalafil may increase the antihypertensive activities of Diltiazem.Approved, Investigational
TalinololDiltiazem may increase the hypotensive activities of Talinolol.Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Diltiazem.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Diltiazem.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Diltiazem.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Diltiazem.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Diltiazem.Experimental
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Diltiazem.Approved
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diltiazem.Approved
TelaprevirThe metabolism of Diltiazem can be decreased when combined with Telaprevir.Withdrawn
TelithromycinThe metabolism of Diltiazem can be decreased when combined with Telithromycin.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Diltiazem.Approved
TemocaprilThe metabolism of Diltiazem can be decreased when combined with Temocapril.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Diltiazem.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Diltiazem.Approved
TerazosinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Terazosin.Approved
TerbinafineThe metabolism of Diltiazem can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Diltiazem.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Diltiazem.Withdrawn
TeriflunomideThe metabolism of Diltiazem can be decreased when combined with Teriflunomide.Approved
TerlipressinDiltiazem may increase the hypotensive activities of Terlipressin.Approved, Investigational
TertatololDiltiazem may increase the hypotensive activities of Tertatolol.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Diltiazem.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Diltiazem.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Diltiazem.Approved, Vet Approved
TetrahydropalmatineDiltiazem may increase the hypotensive activities of Tetrahydropalmatine.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Diltiazem.Approved, Investigational, Withdrawn
TheodrenalineDiltiazem may increase the hypotensive activities of Theodrenaline.Investigational
TheophyllineThe metabolism of Theophylline can be decreased when combined with Diltiazem.Approved
ThiamylalThiamylal may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
ThiopentalThiopental may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Diltiazem.Withdrawn
ThiorphanThe metabolism of Diltiazem can be decreased when combined with Thiorphan.Experimental
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Diltiazem.Approved
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Diltiazem.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Diltiazem.Approved
TiboloneDiltiazem may increase the hypotensive activities of Tibolone.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Diltiazem.Approved
TiclopidineThe metabolism of Diltiazem can be decreased when combined with Ticlopidine.Approved
TicrynafenDiltiazem may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Timolol.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Diltiazem.Approved, Investigational
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Diltiazem.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Diltiazem.Approved
TipranavirThe metabolism of Diltiazem can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Diltiazem can be decreased when it is combined with Tocilizumab.Approved
TofacitinibTofacitinib may increase the bradycardic activities of Diltiazem.Approved, Investigational
TolazolineDiltiazem may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamideThe metabolism of Diltiazem can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Diltiazem.Approved, Withdrawn
TolciclateThe risk or severity of adverse effects can be increased when Tolciclate is combined with Diltiazem.Experimental
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Diltiazem.Approved, Vet Approved
TolonidineDiltiazem may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Diltiazem.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Diltiazem.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Diltiazem.Approved
TopiramateThe metabolism of Diltiazem can be decreased when combined with Topiramate.Approved
TopiroxostatThe metabolism of Diltiazem can be decreased when combined with Topiroxostat.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Diltiazem.Approved, Investigational
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Diltiazem.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Diltiazem.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Diltiazem.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Diltiazem.Approved, Investigational
TrandolaprilThe metabolism of Diltiazem can be decreased when combined with Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Diltiazem.Experimental
TranylcypromineThe metabolism of Diltiazem can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Diltiazem.Approved
TravoprostTravoprost may increase the hypotensive activities of Diltiazem.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Diltiazem.Approved, Investigational
TreprostinilDiltiazem may increase the hypotensive activities of Treprostinil.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Diltiazem.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Diltiazem.Approved, Vet Approved
TriamtereneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Triamterene.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Diltiazem.Approved
TrichlormethiazideDiltiazem may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe serum concentration of Diltiazem can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Diltiazem can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Diltiazem.Experimental
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Diltiazem.Approved
TrimethaphanTrimethaphan may increase the hypotensive activities of Diltiazem.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Diltiazem.Approved, Vet Approved
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Diltiazem.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Diltiazem.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Diltiazem.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Diltiazem.Approved
TylosinThe metabolism of Diltiazem can be decreased when combined with Tylosin.Vet Approved
UbenimexThe metabolism of Diltiazem can be decreased when combined with Ubenimex.Experimental
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Diltiazem.Experimental
UdenafilUdenafil may increase the antihypertensive activities of Diltiazem.Approved, Investigational
UlinastatinThe metabolism of Diltiazem can be decreased when combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Diltiazem.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Diltiazem.Approved
UnoprostoneDiltiazem may increase the hypotensive activities of Unoprostone.Approved
UrapidilUrapidil may increase the hypotensive activities of Diltiazem.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Diltiazem.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Diltiazem.Investigational, Withdrawn
Valproic AcidThe metabolism of Diltiazem can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Diltiazem.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Diltiazem.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Diltiazem.Investigational
VardenafilVardenafil may increase the antihypertensive activities of Diltiazem.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Diltiazem.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Diltiazem.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Diltiazem.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Diltiazem.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Diltiazem.Approved
VerapamilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Diltiazem.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Diltiazem.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Diltiazem.Approved
VildagliptinThe metabolism of Diltiazem can be decreased when combined with Vildagliptin.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Diltiazem.Approved
VincamineDiltiazem may increase the hypotensive activities of Vincamine.Experimental
VincristineThe serum concentration of Vincristine can be increased when it is combined with Diltiazem.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Diltiazem.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Diltiazem.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Diltiazem.Approved, Investigational
VinpocetineDiltiazem may increase the hypotensive activities of Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Diltiazem.Approved
VoriconazoleThe metabolism of Diltiazem can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Diltiazem.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Diltiazem.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Diltiazem.Approved
XimelagatranThe metabolism of Diltiazem can be decreased when combined with Ximelagatran.Approved, Investigational, Withdrawn
XipamideDiltiazem may increase the hypotensive activities of Xipamide.Experimental
XylometazolineDiltiazem may increase the hypotensive activities of Xylometazoline.Approved
YohimbineYohimbine may decrease the antihypertensive activities of Diltiazem.Approved, Vet Approved
Z-Val-Ala-Asp fluoromethyl ketoneThe metabolism of Diltiazem can be decreased when combined with Z-Val-Ala-Asp fluoromethyl ketone.Experimental
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Diltiazem.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Diltiazem.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Diltiazem.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Diltiazem can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Diltiazem can be decreased when combined with Ziprasidone.Approved
ZofenoprilThe metabolism of Diltiazem can be decreased when combined with Zofenopril.Experimental
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Diltiazem.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Diltiazem.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Diltiazem.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Diltiazem.Approved
ZucapsaicinThe metabolism of Diltiazem can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Diltiazem.Approved, Investigational
Food Interactions
  • Avoid natural licorice.
  • Take this medication 30 minutes before meals.

References

Synthesis Reference

Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.

US3562257
General References
Not Available
External Links
Human Metabolome Database
HMDB14487
KEGG Compound
C06958
PubChem Compound
39186
PubChem Substance
46505667
ChemSpider
35850
BindingDB
50004704
ChEBI
101278
ChEMBL
CHEMBL23
Therapeutic Targets Database
DAP001262
PharmGKB
PA449334
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Diltiazem
ATC Codes
C05AE03 — DiltiazemC08DB01 — Diltiazem
AHFS Codes
  • 24:28.92 — Miscellaneous Calcium-channel Blocking Agents
MSDS
Download (73.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableDrug Dependence1
1CompletedNot AvailableNonvalvular Atrial Fibrillation1
1CompletedBasic ScienceDrug-induced QT Interval Prolongation / Pharmacodynamics / Pharmacokinetics1
1CompletedBasic ScienceHealthy Volunteers3
1CompletedBasic ScienceHealthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein1
1CompletedBasic ScienceThrombosis1
1CompletedOtherDrug-induced QT Interval Prolongation / Pharmacodynamics / Pharmacokinetics1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentAtherosclerosis1
1CompletedTreatmentCLARITHROMYCIN/DILTIAZEM [VA Drug Interaction]1
1CompletedTreatmentCardiovascular Disease (CVD) / Human Immunodeficiency Virus (HIV) Infections / Hypertensive1
1CompletedTreatmentHealthy Volunteers2
1CompletedTreatmentHypertensive1
1CompletedTreatmentPharmacokinetics1
1TerminatedOtherHealthy Volunteers1
1TerminatedTreatmentFood Intake1
1Unknown StatusTreatmentAdult Subjects With Anal Fissures1
1Unknown StatusTreatmentDiltiazem Skin Sensitivity1
1Unknown StatusTreatmentSkin Irritation1
1WithdrawnTreatmentChronic Hepatitis C Infection / Hypertensive1
1, 2CompletedTreatmentCraniotomy / Hypertensive1
1, 2CompletedTreatmentMetabolic Syndromes1
2CompletedTreatmentDigital Ulcer of Scleroderma1
2, 3CompletedTreatmentHypertrophic Cardiomyopathy1
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / Hypercholesterolaemia / Hypertensive / Type 2 Diabetes Mellitus1
3CompletedTreatmentArrythmias / Cardiovascular Disease (CVD) / Heart Diseases / Nonvalvular Atrial Fibrillation1
3CompletedTreatmentCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedTreatmentChronic Anal Fissures2
3CompletedTreatmentHeart Failure, Unspecified / Hypertensive1
3CompletedTreatmentNonvalvular Atrial Fibrillation1
3TerminatedTreatmentHeart Failure, Unspecified / Nonvalvular Atrial Fibrillation1
3Unknown StatusTreatmentIschaemia-reperfusion Injury1
3WithdrawnTreatmentDiabetic Nephropathies / Hypertensive1
4CompletedSupportive CarePain1
4CompletedTreatmentAcute Myocardial Infarction (AMI) / Percutaneous Coronary Intervention1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentHeart Rate and Rhythm Disorders1
4CompletedTreatmentRapid Ventricular Response Atrial Fibrillation1
4RecruitingTreatmentAtrial Flutter / Nonvalvular Atrial Fibrillation1
4RecruitingTreatmentFissure in Ano1
4RecruitingTreatmentNonvalvular Atrial Fibrillation / Permanent Atrial Fibrillation1
4Unknown StatusTreatmentNonvalvular Atrial Fibrillation1
Not AvailableCompletedDiagnosticCoronary Artery Ectasia1
Not AvailableCompletedTreatmentArrythmias / Nonvalvular Atrial Fibrillation1
Not AvailableRecruitingTreatmentChronic Anal Fissures1
Not AvailableTerminatedTreatmentNon-Cardiac Chest Pain1
Not AvailableUnknown StatusTreatmentFamilial Primary Pulmonary Hypertension / Idiopathic Pulmonary Arterial Hypertension / Primary Pulmonary Hypertension / Pulmonary Arterial Hypertension (PAH)1

Pharmacoeconomics

Manufacturers
  • Biovail laboratories inc
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  • Watson laboratories inc
  • Apotex inc
  • Actavis elizabeth llc
  • Kv pharmaceutical co
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Apotex inc etobicoke site
  • Biovail corp international
  • Biovail laboratories international srl
  • Apotex inc richmond hill
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • International medication systems ltd
  • Taylor pharmacal co
  • Teva parenteral medicines inc
  • Apothecon inc div bristol myers squibb
  • Dava pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Teva pharmaceuticals usa
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
Capsule, extended releaseOral120 mg
Capsule, extended releaseOral180 mg
Capsule, extended releaseOral240 mg
Capsule, extended releaseOral300 mg
Tablet, coatedOral120 mg/1
Tablet, coatedOral90 mg/1
CapsuleOral240 mg/1
LiquidIntravenous5 mg
Tablet, extended releaseOral120 mg/1
Tablet, extended releaseOral180 mg/1
Tablet, extended releaseOral240 mg/1
Tablet, extended releaseOral300 mg/1
Tablet, extended releaseOral360 mg/1
Tablet, extended releaseOral420 mg/1
Capsule, extended releaseOral60 mg
Capsule, extended releaseOral90 mg
CapsuleOral120 mg/1
CapsuleOral300 mg/1
Injection, solutionIntravenous.83 mg/mL
Injection, solutionIntravenous1 mg/mL
Capsule, coated, extended releaseOral360 mg/1
CapsuleOral180 mg/1
Capsule, extended releaseOral120 mg/1
Capsule, extended releaseOral180 mg/1
Capsule, extended releaseOral240 mg/1
Capsule, extended releaseOral300 mg/1
Capsule, extended releaseOral60 mg/1
Capsule, extended releaseOral90 mg/1
InjectionIntravenous5 mg/mL
Injection, powder, lyophilized, for solutionIntravenous100 mg/1
Injection, solutionIntravenous5 mg/mL
TabletOral120 mg/1
TabletOral30 mg/1
TabletOral60 mg/1
TabletOral90 mg/1
Tablet, coatedOral30 mg/1
Tablet, coatedOral60 mg/1
Tablet, film coatedOral120 mg/1
Tablet, film coatedOral30 mg/1
Tablet, film coatedOral60 mg/1
Tablet, film coatedOral90 mg/1
Capsule, coated, extended releaseOral120 mg/1
Capsule, coated, extended releaseOral180 mg/1
Capsule, coated, extended releaseOral240 mg/1
Capsule, coated, extended releaseOral300 mg/1
CapsuleOral90 mg/1
SolutionIntravenous5 mg
TabletOral30 mg
TabletOral60 mg
Capsule, extended releaseOral360 mg
Capsule, extended releaseOral360 mg/1
Capsule, extended releaseOral420 mg/1
Tablet, extended releaseOral120 mg
Tablet, extended releaseOral180 mg
Tablet, extended releaseOral240 mg
Tablet, extended releaseOral300 mg
Tablet, extended releaseOral360 mg
Prices
Unit descriptionCostUnit
Cormax 0.05% Solution 50ml Bottle81.6USD bottle
Cormax 0.05% Solution 25ml Bottle45.99USD bottle
Cormax 0.05% Cream 15 gm Tube43.98USD tube
Diltiazem hcl 100 mg vial9.54USD vial
Diltiazem hcl powder8.42USD g
Cardizem CD 360 mg 24 Hour Capsule7.94USD capsule
Cardizem cd 360 mg capsule7.63USD capsule
Cardizem CD 300 mg 24 Hour Capsule7.3USD capsule
Cardizem LA 420 mg 24 Hour tablet5.56USD tablet
Cardizem CD 240 mg 24 Hour Capsule5.48USD capsule
Cardizem la 420 mg tablet5.35USD tablet
Diltiazem HCl Coated Beads 420 mg 24 Hour tablet5.01USD tablet
Cardizem la 360 mg tablet4.94USD tablet
Cardizem LA 360 mg 24 Hour tablet4.81USD tablet
Cardizem LA 300 mg 24 Hour tablet4.71USD tablet
Diltiazem HCl Coated Beads 360 mg 24 Hour tablet4.62USD tablet
Cardizem la 300 mg tablet4.59USD tablet
Diltiazem HCl Coated Beads 300 mg 24 Hour tablet4.3USD tablet
Cardizem CD 180 mg 24 Hour Capsule3.98USD capsule
Tiazac 420 mg 24 Hour Capsule3.88USD capsule
Tiazac 360 mg 24 Hour Capsule3.7USD capsule
Cardizem LA 240 mg 24 Hour tablet3.67USD tablet
Tiazac 300 mg 24 Hour Capsule3.64USD capsule
Cardizem la 240 mg tablet3.53USD tablet
Cardizem 120 mg tablet3.49USD tablet
Cardizem CD 120 mg 24 Hour Capsule3.4USD capsule
Dilacor XR 180 mg 24 Hour Capsule3.3USD capsule
Dilacor XR 240 mg 24 Hour Capsule3.3USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour tablet3.3USD tablet
Dilacor xr 240 mg capsule3.29USD capsule
Cardizem Cd 300 mg Controlled-Delivery Capsule3.25USD capsule
Cardizem la 180 mg tablet3.15USD tablet
Cardizem LA 180 mg 24 Hour tablet3.07USD tablet
Dilacor xr 180 mg capsule3.07USD capsule
Tiazac er 420 mg capsule3.03USD capsule
Cardizem la 120 mg tablet2.98USD tablet
Diltiazem HCl Coated Beads 180 mg 24 Hour tablet2.95USD tablet
Diltiazem HCl ER Beads 420 mg 24 Hour Capsule2.87USD capsule
Dilacor XR 120 mg 24 Hour Capsule2.86USD capsule
Tiazac er 360 mg capsule2.86USD capsule
Tiazac er 300 mg capsule2.83USD capsule
Tiazac 240 mg 24 Hour Capsule2.8USD capsule
Cartia XT 300 mg 24 Hour Capsule2.76USD capsule
Dilt-CD 300 mg 24 Hour Capsule2.76USD capsule
Diltiazem HCl Coated Beads 300 mg 24 Hour Capsule2.76USD capsule
Cormax 0.05% cream2.71USD g
Cartia xt 300 mg capsule2.66USD capsule
Dilt-cd er 300 mg capsule2.66USD capsule
Dilacor xr 120 mg capsule2.61USD capsule
Cardizem Cd 240 mg Controlled-Delivery Capsule2.6USD capsule
Diltiazem HCl ER Beads 360 mg 24 Hour Capsule2.44USD capsule
Tiazac 360 mg Extended-Release Capsule2.42USD capsule
Diltiazem HCl ER Beads 300 mg 24 Hour Capsule2.39USD capsule
Cardizem LA 120 mg 24 Hour tablet2.35USD tablet
Tiazac 240 mg capsule sa2.31USD capsule
Tiazac er 240 mg capsule2.18USD capsule
Cardizem cd 300 mg capsule2.15USD capsule
Cartia XT 240 mg 24 Hour Capsule2.13USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour Capsule2.13USD capsule
Dilt-cd 240 mg capsule2.05USD capsule
Cardizem 90 mg tablet2.02USD tablet
Tiazac 180 mg 24 Hour Capsule1.98USD capsule
Tiazac 300 mg Extended-Release Capsule1.98USD capsule
Cardizem Cd 180 mg Controlled-Delivery Capsule1.96USD capsule
Diltiazem HCl ER Beads 240 mg 24 Hour Capsule1.85USD capsule
Cardizem sr 120 mg capsule1.83USD capsule
Apo-Diltiaz Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Novo-Diltazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Ratio-Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Sandoz Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Cardizem cd 240 mg capsule1.69USD capsule
Tiazac 120 mg 24 Hour Capsule1.69USD capsule
Tiazac 240 mg Extended-Release Capsule1.61USD capsule
Tiazac er 180 mg capsule1.52USD capsule
Cartia XT 180 mg 24 Hour Capsule1.5USD capsule
Dilt-CD 180 mg 24 Hour Capsule1.5USD capsule
Diltiazem HCl Coated Beads 180 mg 24 Hour Capsule1.5USD capsule
Cardizem Cd 120 mg Controlled-Delivery Capsule1.48USD capsule
Apo-Diltiaz Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Novo-Diltazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Nu-Diltiaz-Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Ratio-Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Sandoz Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Tiazac Xc 240 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 300 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 360 mg Extended-Release Tablet1.46USD tablet
Dilt-cd 180 mg capsule1.45USD capsule
Diltiazem HCl 120 mg tablet1.42USD tablet
Diltiazem 120 mg tablet1.36USD tablet
Apo-Diltiaz Tz 360 mg Extended-Release Capsule1.36USD capsule
Novo-Diltiazem Hcl Er 360 mg Extended-Release Capsule1.36USD capsule
Sandoz Diltiazem T 360 mg Extended-Release Capsule1.36USD capsule
Cardizem 30 mg tablet1.34USD tablet
Diltiazem HCl ER Beads 180 mg 24 Hour Capsule1.3USD capsule
Diltiazem HCl CR 120 mg 12 Hour Capsule1.29USD capsule
Tiazac er 120 mg capsule1.26USD capsule
Cartia XT 120 mg 24 Hour Capsule1.25USD capsule
Dilt-CD 120 mg 24 Hour Capsule1.25USD capsule
Diltiazem HCl Coated Beads 120 mg 24 Hour Capsule1.25USD capsule
Cardizem cd 180 mg capsule1.24USD capsule
Tiazac 180 mg Extended-Release Capsule1.21USD capsule
Cartia xt 120 mg capsule1.2USD capsule
Dilt-cd 120 mg capsule1.2USD capsule
Diltiazem HCl CR 240 mg 24 Hour Capsule1.19USD capsule
Diltia XT 240 mg 24 Hour Capsule1.17USD capsule
Diltiazem HCl CR 180 mg 24 Hour Capsule1.11USD capsule
Apo-Diltiaz Tz 300 mg Extended-Release Capsule1.11USD capsule
Novo-Diltiazem Hcl Er 300 mg Extended-Release Capsule1.11USD capsule
Sandoz Diltiazem T 300 mg Extended-Release Capsule1.11USD capsule
Tiazac Xc 180 mg Extended-Release Tablet1.1USD tablet
Diltia XT 180 mg 24 Hour Capsule1.1USD capsule
Apo-Diltiaz Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Novo-Diltazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Nu-Diltiaz-Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Ratio-Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Sandoz Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Diltiazem HCl ER Beads 120 mg 24 Hour Capsule1.08USD capsule
Diltiazem HCl 90 mg tablet1.05USD tablet
Diltiazem 90 mg tablet1.01USD tablet
Diltiazem HCl CR 90 mg 12 Hour Capsule0.99USD capsule
Cardizem cd 120 mg capsule0.97USD capsule
Cardizem 60 mg tablet0.95USD tablet
Diltiazem HCl CR 120 mg 24 Hour Capsule0.95USD capsule
Apo-Diltiaz Tz 240 mg Extended-Release Capsule0.9USD capsule
Novo-Diltiazem Hcl Er 240 mg Extended-Release Capsule0.9USD capsule
Sandoz Diltiazem T 240 mg Extended-Release Capsule0.9USD capsule
Tiazac 120 mg Extended-Release Capsule0.89USD capsule
Diltiazem HCl CR 60 mg 12 Hour Capsule0.86USD capsule
Apo-Diltiaz Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Novo-Diltazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Nu-Diltiaz-Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Ratio-Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Sandoz Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Tiazac Xc 120 mg Extended-Release Tablet0.83USD tablet
Cartia xt 240 mg capsule0.81USD capsule
Diltiazem HCl 60 mg tablet0.77USD tablet
Diltiazem 60 mg tablet0.74USD tablet
Apo-Diltiaz Tz 180 mg Extended-Release Capsule0.68USD capsule
Novo-Diltiazem Hcl Er 180 mg Extended-Release Capsule0.68USD capsule
Sandoz Diltiazem T 180 mg Extended-Release Capsule0.68USD capsule
Cartia xt 180 mg capsule0.6USD capsule
Apo-Diltiaz Tz 120 mg Extended-Release Capsule0.5USD capsule
Novo-Diltiazem Hcl Er 120 mg Extended-Release Capsule0.5USD capsule
Sandoz Diltiazem T 120 mg Extended-Release Capsule0.5USD capsule
Diltiazem HCl 30 mg tablet0.49USD tablet
Diltiazem 30 mg tablet0.47USD tablet
Diltia xt 240 mg capsule0.43USD capsule
Diltia xt 180 mg capsule0.42USD capsule
Diltiazem-d5w 250 mg/250 ml0.42USD ml
Diltia xt 120 mg capsule0.38USD capsule
Apo-Diltiaz 60 mg Tablet0.38USD tablet
Novo-Diltazem 60 mg Tablet0.38USD tablet
Nu-Diltiaz 60 mg Tablet0.38USD tablet
Apo-Diltiaz 30 mg Tablet0.22USD tablet
Novo-Diltazem 30 mg Tablet0.22USD tablet
Nu-Diltiaz 30 mg Tablet0.22USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5286497No1994-05-202011-05-20Us
CA2307547No2007-08-142020-05-04Canada
CA2111085No1999-04-272012-06-25Canada
US7108866No1999-12-172019-12-17Us
US6923984No2001-02-252021-02-25Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)187-188Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.
water solubility465 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP2.8Not Available
Caco2 permeability-4.38ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0168 mg/mLALOGPS
logP3.09ALOGPS
logP2.73ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.86ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.08 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity114.37 m3·mol-1ChemAxon
Polarizability43.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9788
Blood Brain Barrier+0.506
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8645
P-glycoprotein inhibitor IInhibitor0.8675
P-glycoprotein inhibitor IIInhibitor0.8997
Renal organic cation transporterNon-inhibitor0.7634
CYP450 2C9 substrateNon-substrate0.699
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8681
Ames testNon AMES toxic0.6985
CarcinogenicityNon-carcinogens0.8772
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.4130 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Inhibitor0.7723
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0ab9-9200000000-b1095b8fe5973d23fdd6
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzothiazepines. These are organic compounds containing a benzene fused to a thiazepine ring (a seven-membered ring with a nitrogen atom and a sulfur atom replacing two carbon atoms).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazepines
Sub Class
Not Available
Direct Parent
Benzothiazepines
Alternative Parents
Phenoxy compounds / Methoxybenzenes / Anisoles / Alkyl aryl ethers / Alkylarylthioethers / Tertiary carboxylic acid amides / Trialkylamines / Amino acids and derivatives / Lactams / Carboxylic acid esters
show 6 more
Substituents
Benzothiazepine / Phenoxy compound / Aryl thioether / Anisole / Phenol ether / Methoxybenzene / Alkyl aryl ether / Alkylarylthioether / Monocyclic benzene moiety / Benzenoid
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (CHEBI:101278)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only...
Gene Name
CACNG1
Uniprot ID
Q06432
Uniprot Name
Voltage-dependent calcium channel gamma-1 subunit
Molecular Weight
25028.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A: Ligands of diltiazem binding site: an overview of some chemotypes. Mini Rev Med Chem. 2009 Oct;9(12):1379-88. [PubMed:19929811]
  4. Romero M, Sanchez I, Pujol MD: New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships. Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):113-41. [PubMed:15320693]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. [PubMed:12124305]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K: Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. [PubMed:11560871]
  2. McGinnity DF, Parker AJ, Soars M, Riley RJ: Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos. 2000 Nov;28(11):1327-34. [PubMed:11038161]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674]
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. [PubMed:12128170]
  3. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett. 1993 Jun 7;324(1):99-102. [PubMed:8099333]

Drug created on June 13, 2005 07:24 / Updated on October 21, 2017 19:21