Identification

Name
Diltiazem
Accession Number
DB00343  (APRD00473)
Type
Small Molecule
Groups
Approved, Investigational
Description

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic.

Structure
Thumb
Synonyms
  • (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
  • D-cis-diltiazem
  • Diltiazem
  • Diltiazemum
Product Ingredients
IngredientUNIICASInChI Key
Diltiazem hydrochlorideOLH94387TE33286-22-5HDRXZJPWHTXQRI-BHDTVMLSSA-N
Diltiazem malate14Y6444DRP144604-00-2IUSFTUWHKCSCDY-QTKZZPNDSA-N
Diltiazem maleate896626Q8XW139492-78-7WHBXLOWLFLTDMD-WECFPGDBSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Diltiazem CDCapsule, extended release120 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release240 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release180 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem CDCapsule, extended release300 mgOralTeva2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release360 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release180 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release300 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release120 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem TCapsule, extended release240 mgOralActavis Pharma Company2011-10-06Not applicableCanada
Apo Diltiaz Tab 30mgTablet30 mgOralApotex Corporation1988-12-31Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-diltiazem Tab 30mgTablet30 mgOralAltimed Pharma Inc.1990-12-312005-05-27Canada
Alti-diltiazem Tab 60mgTablet60 mgOralAltimed Pharma Inc.1990-12-312005-05-27Canada
Apo-diltiaz CDCapsule, extended release240 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CDCapsule, extended release180 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CDCapsule, extended release120 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-diltiaz CD - Cap 300mgCapsule, extended release300 mgOralApotex Corporation1996-09-12Not applicableCanada
Apo-diltiaz InjectableLiquid5 mgIntravenousApotex Corporation2000-06-202013-08-02Canada
Apo-diltiaz SR - 90mg/srcCapsule, extended release90 mgOralApotex Corporation1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 120mgCapsule, extended release120 mgOralApotex Corporation1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 60mgCapsule, extended release60 mgOralApotex Corporation1996-09-19Not applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Diltiazem HClDiltiazem hydrochloride (1 mg/mL)Injection, solutionIntravenousCantrell Drug Company2011-09-302017-12-22Us
Diltiazem HClDiltiazem hydrochloride (.83 mg/mL)Injection, solutionIntravenousCantrell Drug Company2013-10-22Not applicableUs
International/Other Brands
Acalix (Roemmers) / Adizem (Mundipharma) / Altiazem (Lusofarmaco) / Anoheal / Calcicard / Cartia / Dilacor / Dilacor-XR (Watson) / Dilcontin (Modi-Mundipharma) / Dilrene (Sanofi) / Diltia XT / Dilticard (Intra) / Dilzem (Pfizer) / Herbesser (Mitsubishi Tanabe) / Incoril AP (Bago) / Masdil (Esteve) / Surazem / TAZTIA / Tildem / Viazem (Biovail)
Categories
UNII
EE92BBP03H
CAS number
42399-41-7
Weight
Average: 414.518
Monoisotopic: 414.16132802
Chemical Formula
C22H26N2O4S
InChI Key
HSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
SMILES
COC1=CC=C(C=C1)[C@@H]1SC2=C(C=CC=C2)N(CCN(C)C)C(=O)[C@@H]1OC(C)=O

Pharmacology

Indication

For the treatment of Hypertension

Associated Conditions
Pharmacodynamics

Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is a non-dihydropyridine (DHP)member of the calcium channel blocker class, along with Verapamil. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Mechanism of action

Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

TargetActionsOrganism
AVoltage-dependent calcium channel gamma-1 subunit
inhibitor
Human
Absorption

Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Volume of distribution
Not Available
Protein binding

70%-80%

Metabolism

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

Route of elimination
Not Available
Half life

3.0 - 4.5 hours

Clearance
Not Available
Toxicity

LD50=740mg/kg (orally in mice)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Diltiazem Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Beta-1 adrenergic receptor---(G;G) / (C;G)C > GEffect Directly StudiedPatients with this genotype require a lower dosage of diltiazem to achieve a favourable rate-control response when treating atrial fibrillation.Details

Interactions

Drug Interactions
DrugInteractionDrug group
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Diltiazem.Experimental
(S)-WarfarinThe metabolism of (S)-Warfarin can be decreased when combined with Diltiazem.Experimental, Investigational
16-BromoepiandrosteroneThe metabolism of 16-Bromoepiandrosterone can be decreased when combined with Diltiazem.Investigational
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Diltiazem.Investigational
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Diltiazem.Experimental
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Diltiazem.Experimental, Illicit
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Diltiazem.Investigational
AbafunginThe therapeutic efficacy of Abafungin can be increased when used in combination with Diltiazem.Investigational
AbemaciclibThe risk or severity of adverse effects can be increased when Diltiazem is combined with Abemaciclib.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Diltiazem.Approved
AcebutololDiltiazem may increase the hypotensive activities of Acebutolol.Approved, Investigational
AceclofenacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Aceclofenac.Approved, Investigational
AcemetacinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Diltiazem.Approved, Investigational
AcepromazineThe risk or severity of hypotension can be increased when Acepromazine is combined with Diltiazem.Approved, Vet Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Diltiazem.Approved
AcetyldigitoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Acetyldigitoxin.Approved
AcetyldigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Acetyldigoxin.Experimental
Acetylsalicylic acidDiltiazem may increase the anticoagulant activities of Acetylsalicylic acid.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Diltiazem.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Diltiazem.Approved
AgmatineThe metabolism of Agmatine can be decreased when combined with Diltiazem.Experimental, Investigational
AlbaconazoleThe therapeutic efficacy of Albaconazole can be increased when used in combination with Diltiazem.Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Diltiazem.Approved, Vet Approved
AlclofenacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Alclofenac.Approved, Withdrawn
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Diltiazem.Approved
AlcuroniumDiltiazem may increase the neuromuscular blocking activities of Alcuronium.Experimental
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Diltiazem.Approved
AldosteroneThe metabolism of Aldosterone can be decreased when combined with Diltiazem.Experimental, Investigational
AlectinibThe serum concentration of Diltiazem can be increased when it is combined with Alectinib.Approved, Investigational
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Diltiazem.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Diltiazem.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Diltiazem.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Diltiazem.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Diltiazem.Approved
AlminoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Alminoprofen.Experimental
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Diltiazem.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Diltiazem.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Diltiazem.Approved, Withdrawn
AloxiprinDiltiazem may increase the anticoagulant activities of Aloxiprin.Experimental
alpha-Tocopherol acetateThe metabolism of alpha-Tocopherol acetate can be decreased when combined with Diltiazem.Approved
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Diltiazem.Approved, Illicit, Investigational
AlprenololDiltiazem may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Diltiazem.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Diltiazem.Approved, Investigational
AmcinonideThe metabolism of Amcinonide can be decreased when combined with Diltiazem.Approved
AmifostineDiltiazem may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amiloride.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Diltiazem.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Diltiazem.Approved
Aminosalicylic AcidDiltiazem may increase the anticoagulant activities of Aminosalicylic Acid.Approved
AmiodaroneThe risk or severity of bradycardia can be increased when Diltiazem is combined with Amiodarone.Approved, Investigational
AmitriptylineThe risk or severity of hypotension can be increased when Amitriptyline is combined with Diltiazem.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Diltiazem.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Diltiazem.Approved, Illicit
AmodiaquineThe serum concentration of Diltiazem can be increased when it is combined with Amodiaquine.Approved, Investigational
AmoxapineThe risk or severity of hypotension can be increased when Amoxapine is combined with Diltiazem.Approved
Amphotericin BDiltiazem may decrease the nephrotoxic activities of Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Diltiazem.Approved, Investigational
AmsacrineThe serum concentration of Diltiazem can be increased when it is combined with Amsacrine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amyl Nitrite.Approved
AndrostenedioneThe metabolism of Androstenedione can be decreased when combined with Diltiazem.Experimental, Illicit
AnisodamineDiltiazem may increase the hypotensive activities of Anisodamine.Investigational
AnnamycinThe serum concentration of Diltiazem can be increased when it is combined with Annamycin.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Diltiazem.Approved, Investigational
AntrafenineThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Antrafenine.Approved
ApalutamideThe serum concentration of Apalutamide can be increased when it is combined with Diltiazem.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Diltiazem.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Diltiazem.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Apraclonidine.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Diltiazem.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Diltiazem.Approved, Investigational
AranidipineThe metabolism of Aranidipine can be decreased when combined with Diltiazem.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Diltiazem.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Diltiazem.Approved, Investigational
Aripiprazole lauroxilThe serum concentration of aripiprazole, an active metabolite of Diltiazem, can be increased when used in combination with Aripiprazole lauroxil.Approved, Investigational
ArotinololThe risk or severity of hypotension can be increased when Arotinolol is combined with Diltiazem.Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Diltiazem.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Diltiazem.Approved
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Diltiazem.Approved, Nutraceutical
AsenapineThe risk or severity of hypotension can be increased when Asenapine is combined with Diltiazem.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Diltiazem.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Diltiazem.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Diltiazem.Approved, Investigational
AtenololDiltiazem may increase the hypotensive activities of Atenolol.Approved
AtorvastatinThe serum concentration of Diltiazem can be increased when it is combined with Atorvastatin.Approved
AtovaquoneThe metabolism of Atovaquone can be decreased when combined with Diltiazem.Approved
AtracuriumDiltiazem may increase the neuromuscular blocking activities of Atracurium.Approved, Experimental, Investigational
Atracurium besylateDiltiazem may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Diltiazem.Approved
AvatrombopagThe serum concentration of Avatrombopag can be increased when it is combined with Diltiazem.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Diltiazem.Approved, Investigational
AzapropazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Azapropazone.Withdrawn
AzelastineThe metabolism of Azelastine can be decreased when combined with Diltiazem.Approved
AzelnidipineThe metabolism of Azelnidipine can be decreased when combined with Diltiazem.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Azilsartan medoxomil.Approved, Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Diltiazem.Approved
Bafilomycin A1The serum concentration of Diltiazem can be increased when it is combined with Bafilomycin A1.Experimental
Bafilomycin B1The serum concentration of Diltiazem can be increased when it is combined with Bafilomycin B1.Experimental
BalaglitazoneThe metabolism of Balaglitazone can be decreased when combined with Diltiazem.Investigational
BalsalazideDiltiazem may increase the anticoagulant activities of Balsalazide.Approved, Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Diltiazem.Investigational
BarbexacloneBarbexaclone may increase the hypotensive activities of Diltiazem.Experimental
BarbitalBarbital may increase the hypotensive activities of Diltiazem.Illicit
BaricitinibThe metabolism of Baricitinib can be decreased when combined with Diltiazem.Approved, Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Diltiazem.Approved
Beclomethasone dipropionateThe metabolism of Beclomethasone dipropionate can be decreased when combined with Diltiazem.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Diltiazem.Approved
BefunololDiltiazem may increase the hypotensive activities of Befunolol.Experimental
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Diltiazem.Approved, Investigational
BenazeprilDiltiazem may increase the hypotensive activities of Benazepril.Approved, Investigational
BenazeprilatDiltiazem may increase the hypotensive activities of Benazeprilat.Experimental
BencyclaneThe metabolism of Bencyclane can be decreased when combined with Diltiazem.Experimental
BendazacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Bendazac.Experimental
BendroflumethiazideDiltiazem may increase the hypotensive activities of Bendroflumethiazide.Approved
BenidipineThe metabolism of Benidipine can be decreased when combined with Diltiazem.Approved, Investigational
BenmoxinBenmoxin may increase the hypotensive activities of Diltiazem.Withdrawn
BenorilateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Benorilate.Experimental
BenoxaprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Benoxaprofen.Withdrawn
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Diltiazem.Approved, Illicit
BenzquinamideThe serum concentration of Diltiazem can be increased when it is combined with Benzquinamide.Withdrawn
BenzydamineThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Benzydamine.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Diltiazem.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Diltiazem.Approved, Withdrawn
BeractantDiltiazem may increase the bradycardic activities of Beractant.Approved
BetamethasoneThe metabolism of Betamethasone can be decreased when combined with Diltiazem.Approved, Vet Approved
BetaxololDiltiazem may increase the hypotensive activities of Betaxolol.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Diltiazem.Approved
BevantololDiltiazem may increase the hypotensive activities of Bevantolol.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Diltiazem.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Diltiazem.Approved, Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Diltiazem.Approved
BictegravirThe metabolism of Bictegravir can be decreased when combined with Diltiazem.Approved, Investigational
BietaserpineBietaserpine may increase the hypotensive activities of Diltiazem.Experimental
BifonazoleThe therapeutic efficacy of Bifonazole can be increased when used in combination with Diltiazem.Approved, Investigational
BimatoprostDiltiazem may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be decreased when combined with Diltiazem.Approved, Experimental
Biricodar dicitrateThe serum concentration of Diltiazem can be increased when it is combined with Biricodar dicitrate.Investigational
BisacodylThe therapeutic efficacy of Bisacodyl can be decreased when used in combination with Diltiazem.Approved
BisoprololDiltiazem may increase the hypotensive activities of Bisoprolol.Approved
BisoxatinThe therapeutic efficacy of Bisoxatin can be decreased when used in combination with Diltiazem.Approved
BlonanserinThe metabolism of Blonanserin can be decreased when combined with Diltiazem.Approved, Investigational
BoceprevirThe metabolism of Diltiazem can be decreased when combined with Boceprevir.Approved, Withdrawn
BopindololDiltiazem may increase the hypotensive activities of Bopindolol.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Diltiazem.Approved, Investigational
BosentanThe serum concentration of Diltiazem can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Diltiazem.Approved
BQ-123Diltiazem may increase the hypotensive activities of BQ-123.Investigational
Brefeldin AThe serum concentration of Diltiazem can be increased when it is combined with Brefeldin A.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Diltiazem.Approved, Investigational
BretyliumBretylium may increase the bradycardic activities of Diltiazem.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Diltiazem.Approved, Investigational
BrigatinibThe metabolism of Brigatinib can be decreased when combined with Diltiazem.Approved, Investigational
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Diltiazem.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Diltiazem.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
BromfenacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Bromfenac.Approved
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Diltiazem.Approved, Investigational
BromperidolThe serum concentration of Bromperidol can be increased when it is combined with Diltiazem.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Diltiazem.Approved
BucindololDiltiazem may increase the hypotensive activities of Bucindolol.Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Diltiazem.Approved
BufexamacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Bufexamac.Approved, Experimental
BufuralolDiltiazem may increase the hypotensive activities of Bufuralol.Experimental, Investigational
BumadizoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Bumadizone.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Bumetanide.Approved
BunazosinThe risk or severity of hypotension can be increased when Bunazosin is combined with Diltiazem.Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Diltiazem.Approved, Investigational
BupranololDiltiazem may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Diltiazem.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Diltiazem.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Diltiazem.Approved, Investigational
ButoconazoleThe therapeutic efficacy of Butoconazole can be increased when used in combination with Diltiazem.Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Diltiazem.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Diltiazem.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Diltiazem.Approved, Investigational
CadralazineCadralazine may increase the hypotensive activities of Diltiazem.Experimental
CaffeineThe metabolism of Caffeine can be decreased when combined with Diltiazem.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Diltiazem.Approved, Nutraceutical
Calcium AcetateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Acetate.Approved, Investigational
Calcium CarbonateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Carbonate.Approved, Investigational
Calcium ChlorideThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium lactate.Approved, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium levulinateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium levulinate.Approved, Experimental
Calcium pangamateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Phosphate.Approved
CalfactantDiltiazem may increase the bradycardic activities of Calfactant.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Diltiazem.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Diltiazem.Approved
CandesartanDiltiazem may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilDiltiazem may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilDiltiazem may increase the hypotensive activities of Candoxatril.Experimental
CannabidiolThe metabolism of Cannabidiol can be decreased when combined with Diltiazem.Approved, Investigational
CaptoprilThe serum concentration of Diltiazem can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Diltiazem.Approved, Investigational
Carbaspirin calciumDiltiazem may increase the anticoagulant activities of Carbaspirin calcium.Experimental, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Diltiazem.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Diltiazem.Approved
CarboxyamidotriazoleThe metabolism of Carboxyamidotriazole can be decreased when combined with Diltiazem.Investigational
CarboxymethylcelluloseThe therapeutic efficacy of Carboxymethylcellulose can be decreased when used in combination with Diltiazem.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Diltiazem.Approved, Investigational
CariprazineThe metabolism of Cariprazine can be decreased when combined with Diltiazem.Approved, Investigational
CaroverineThe metabolism of Caroverine can be decreased when combined with Diltiazem.Experimental
CaroxazoneCaroxazone may increase the hypotensive activities of Diltiazem.Withdrawn
CarprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Carprofen.Approved, Vet Approved, Withdrawn
CarteololDiltiazem may increase the hypotensive activities of Carteolol.Approved
CarvedilolDiltiazem may increase the hypotensive activities of Carvedilol.Approved, Investigational
Castor oilThe therapeutic efficacy of Castor oil can be decreased when used in combination with Diltiazem.Approved, Investigational, Nutraceutical, Vet Approved
CefoperazoneThe serum concentration of Diltiazem can be increased when it is combined with Cefoperazone.Approved, Investigational
CeftriaxoneThe serum concentration of Diltiazem can be increased when it is combined with Ceftriaxone.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Diltiazem.Approved, Investigational
CeliprololDiltiazem may increase the hypotensive activities of Celiprolol.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
CeritinibDiltiazem may increase the bradycardic activities of Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Diltiazem.Approved, Withdrawn
Cerliponase alfaThe serum concentration of Cerliponase alfa can be increased when it is combined with Diltiazem.Approved, Investigational
CevimelineThe metabolism of Cevimeline can be decreased when combined with Diltiazem.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Diltiazem.Approved
ChlorambucilThe serum concentration of Chlorambucil can be increased when it is combined with Diltiazem.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
ChlormadinoneThe metabolism of Chlormadinone can be decreased when combined with Diltiazem.Experimental
ChloroformThe serum concentration of Diltiazem can be increased when it is combined with Chloroform.Vet Approved
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
ChlorothiazideDiltiazem may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Diltiazem.Approved
ChlorpromazineThe risk or severity of hypotension can be increased when Chlorpromazine is combined with Diltiazem.Approved, Investigational, Vet Approved
ChlorprothixeneThe serum concentration of Diltiazem can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Diltiazem.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Diltiazem.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Diltiazem.Approved, Nutraceutical
Choline magnesium trisalicylateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Choline magnesium trisalicylate.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Diltiazem.Approved, Investigational
CicletanineDiltiazem may increase the hypotensive activities of Cicletanine.Investigational
CiglitazoneThe metabolism of Ciglitazone can be decreased when combined with Diltiazem.Experimental
CilazaprilDiltiazem may increase the hypotensive activities of Cilazapril.Approved
CilnidipineThe metabolism of Cilnidipine can be decreased when combined with Diltiazem.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Diltiazem.Approved, Investigational
CimetidineThe serum concentration of Diltiazem can be increased when it is combined with Cimetidine.Approved, Investigational
CimicoxibThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Cimicoxib.Investigational
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Diltiazem.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Diltiazem.Approved, Investigational
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Diltiazem.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
CisatracuriumDiltiazem may increase the neuromuscular blocking activities of Cisatracurium.Approved
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Diltiazem.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Diltiazem.Approved
ClarithromycinThe metabolism of Diltiazem can be decreased when combined with Clarithromycin.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Diltiazem.Approved, Investigational
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Diltiazem.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Diltiazem.Approved, Illicit
ClobetasolThe metabolism of Clobetasol can be decreased when combined with Diltiazem.Approved, Investigational
Clobetasol propionateThe metabolism of Clobetasol propionate can be decreased when combined with Diltiazem.Approved
ClobetasoneThe metabolism of Clobetasone can be decreased when combined with Diltiazem.Approved
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Diltiazem.Approved, Investigational
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Diltiazem.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Diltiazem.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Diltiazem.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Diltiazem.Approved, Illicit
ClonidineClonidine may increase the atrioventricular blocking (AV block) activities of Diltiazem.Approved
ClonixinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Clonixin.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Diltiazem.Approved
CloranololDiltiazem may increase the hypotensive activities of Cloranolol.Experimental
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Diltiazem.Approved, Illicit
ClorindioneThe metabolism of Clorindione can be decreased when combined with Diltiazem.Experimental
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Diltiazem.Approved, Illicit
ClotrimazoleThe metabolism of Diltiazem can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of hypotension can be increased when Clozapine is combined with Diltiazem.Approved
CobicistatThe metabolism of Diltiazem can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Diltiazem.Approved, Investigational
CocaineThe metabolism of Cocaine can be decreased when combined with Diltiazem.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Diltiazem.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Diltiazem.Approved
ColestipolColestipol can cause a decrease in the absorption of Diltiazem resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Concanamycin AThe serum concentration of Diltiazem can be increased when it is combined with Concanamycin A.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Diltiazem.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Diltiazem.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Diltiazem.Approved, Investigational
CorticosteroneThe metabolism of Corticosterone can be decreased when combined with Diltiazem.Experimental
CorticotropinThe metabolism of Corticotropin can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Diltiazem.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Diltiazem.Approved
CryptenamineDiltiazem may increase the hypotensive activities of Cryptenamine.Approved
CurcuminThe metabolism of Diltiazem can be decreased when combined with Curcumin.Approved, Investigational
CyclandelateThe metabolism of Cyclandelate can be decreased when combined with Diltiazem.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Diltiazem.Approved
CyclopenthiazideDiltiazem may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Diltiazem.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
CyclothiazideDiltiazem may increase the hypotensive activities of Cyclothiazide.Approved
CymarinDiltiazem may increase the atrioventricular blocking (AV block) activities of Cymarin.Experimental
Cyproterone acetateThe metabolism of Cyproterone acetate can be decreased when combined with Diltiazem.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be decreased when combined with Diltiazem.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Diltiazem.Approved
DabrafenibThe serum concentration of Diltiazem can be decreased when it is combined with Dabrafenib.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Diltiazem.Approved, Investigational
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Diltiazem.Approved, Investigational
DanazolThe metabolism of Diltiazem can be decreased when combined with Danazol.Approved
DanthronThe therapeutic efficacy of Danthron can be decreased when used in combination with Diltiazem.Approved, Investigational, Withdrawn
DantroleneDantrolene may increase the hyperkalemic activities of Diltiazem.Approved, Investigational
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Diltiazem.Approved
DapiprazoleThe risk or severity of hypotension can be increased when Dapiprazole is combined with Diltiazem.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Diltiazem.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Diltiazem.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Diltiazem.Approved, Investigational
DarodipineThe metabolism of Darodipine can be decreased when combined with Diltiazem.Experimental
DarunavirThe metabolism of Diltiazem can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Diltiazem.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Diltiazem.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Diltiazem.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Diltiazem.Approved, Investigational
DeferasiroxThe serum concentration of Diltiazem can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Diltiazem.Approved, Investigational
DelamanidDiltiazem may increase the QTc-prolonging activities of Delamanid.Approved, Investigational
DelaprilDiltiazem may increase the hypotensive activities of Delapril.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Diltiazem.Approved
DemegestoneThe metabolism of Demegestone can be decreased when combined with Diltiazem.Approved
DersalazineDiltiazem may increase the anticoagulant activities of Dersalazine.Investigational
DeserpidineDiltiazem may increase the hypotensive activities of Deserpidine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Diltiazem.Approved
DesipramineThe serum concentration of Diltiazem can be increased when it is combined with Desipramine.Approved, Investigational
DeslanosideDiltiazem may increase the atrioventricular blocking (AV block) activities of Deslanoside.Approved
DesmethylsertralineThe serum concentration of Diltiazem can be increased when it is combined with Desmethylsertraline.Experimental
DesogestrelThe metabolism of Desogestrel can be decreased when combined with Diltiazem.Approved
DesonideThe metabolism of Desonide can be decreased when combined with Diltiazem.Approved, Investigational
Desoxycorticosterone acetateThe metabolism of Desoxycorticosterone acetate can be decreased when combined with Diltiazem.Approved
Desoxycorticosterone PivalateThe metabolism of Desoxycorticosterone Pivalate can be decreased when combined with Diltiazem.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Diltiazem.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Diltiazem.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe metabolism of Dexamethasone isonicotinate can be decreased when combined with Diltiazem.Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Diltiazem.Approved
DexibuprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Dexibuprofen.Approved, Investigational
DexketoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Dexketoprofen.Approved, Investigational
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Diltiazem.Approved, Investigational
DexmedetomidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dexmedetomidine.Approved, Vet Approved
DexniguldipineThe metabolism of Dexniguldipine can be decreased when combined with Diltiazem.Experimental
DexrabeprazoleThe metabolism of Dexrabeprazole can be decreased when combined with Diltiazem.Experimental
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Diltiazem.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Withdrawn
DexverapamilThe metabolism of Dexverapamil can be decreased when combined with Diltiazem.Experimental
DiazepamThe metabolism of Diazepam can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Diltiazem.Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Diltiazem.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Diclofenamide.Approved, Investigational
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Diltiazem.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Diltiazem.Approved
Diethyl etherThe serum concentration of Diltiazem can be increased when it is combined with Diethyl ether.Experimental
DiethylnorspermineDiltiazem may increase the hypotensive activities of Diethylnorspermine.Investigational
DiethylstilbestrolThe metabolism of Diethylstilbestrol can be decreased when combined with Diltiazem.Approved, Investigational
DifenpiramideThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Difenpiramide.Experimental
DiflunisalDiltiazem may increase the anticoagulant activities of Diflunisal.Approved, Investigational
DifluocortoloneThe metabolism of Difluocortolone can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
DifluprednateThe metabolism of Difluprednate can be decreased when combined with Diltiazem.Approved
DigitoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Digitoxin.Approved, Investigational
DigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Digoxin.Approved
DihydralazineDihydralazine may increase the hypotensive activities of Diltiazem.Approved, Investigational
Dihydro-alpha-ergocryptineThe metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Diltiazem.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Diltiazem.Approved, Illicit
DihydroergocornineThe metabolism of Dihydroergocornine can be decreased when combined with Diltiazem.Approved
DihydroergocristineThe metabolism of Dihydroergocristine can be decreased when combined with Diltiazem.Approved, Experimental
DihydroergocryptineThe metabolism of Dihydroergocryptine can be decreased when combined with Diltiazem.Experimental
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Diltiazem.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dinutuximab.Approved, Investigational
DiphenadioneThe metabolism of Diphenadione can be decreased when combined with Diltiazem.Experimental
DipyridamoleDipyridamole may increase the antihypertensive activities of Diltiazem.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Diltiazem.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Diltiazem.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Diltiazem.Approved, Investigational
DocusateThe therapeutic efficacy of Docusate can be decreased when used in combination with Diltiazem.Approved
DofequidarThe serum concentration of Diltiazem can be increased when it is combined with Dofequidar.Experimental, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Diltiazem.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Diltiazem.Approved, Investigational
DolutegravirThe serum concentration of Dolutegravir can be increased when it is combined with Diltiazem.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Diltiazem.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Diltiazem.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Diltiazem.Approved
DotarizineThe metabolism of Dotarizine can be decreased when combined with Diltiazem.Investigational
DovitinibThe serum concentration of Diltiazem can be increased when it is combined with Dovitinib.Investigational
DoxacuriumDiltiazem may increase the neuromuscular blocking activities of Doxacurium.Approved
DoxazosinThe risk or severity of hypotension can be increased when Doxazosin is combined with Diltiazem.Approved
DoxepinThe risk or severity of hypotension can be increased when Doxepin is combined with Diltiazem.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Diltiazem.Approved, Investigational
DoxycyclineThe metabolism of Diltiazem can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Diltiazem.Approved
DroperidolThe risk or severity of hypotension can be increased when Droperidol is combined with Diltiazem.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Diltiazem.Approved
DroxicamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Droxicam.Withdrawn
DuloxetineDiltiazem may increase the orthostatic hypotensive activities of Duloxetine.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Diltiazem.Approved, Investigational
DydrogesteroneThe metabolism of Dydrogesterone can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
EconazoleThe serum concentration of Diltiazem can be increased when it is combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Diltiazem.Approved
EfinaconazoleThe therapeutic efficacy of Efinaconazole can be increased when used in combination with Diltiazem.Approved
EfonidipineThe metabolism of Efonidipine can be decreased when combined with Diltiazem.Approved, Investigational
ElacridarThe serum concentration of Diltiazem can be increased when it is combined with Elacridar.Investigational
ElagolixThe serum concentration of Elagolix can be increased when it is combined with Diltiazem.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Diltiazem.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Diltiazem.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Diltiazem.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Diltiazem.Approved
EmopamilThe metabolism of Emopamil can be decreased when combined with Diltiazem.Experimental
EmpagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Empagliflozin.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Diltiazem.Approved, Vet Approved
EnalaprilatDiltiazem may increase the hypotensive activities of Enalaprilat.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Diltiazem.Approved, Investigational
EncorafenibThe metabolism of Encorafenib can be decreased when combined with Diltiazem.Approved, Investigational
EndralazineEndralazine may increase the hypotensive activities of Diltiazem.Experimental
EnzalutamideThe serum concentration of Diltiazem can be decreased when it is combined with Enzalutamide.Approved
EpanololDiltiazem may increase the hypotensive activities of Epanolol.Experimental
EperisoneThe metabolism of Eperisone can be decreased when combined with Diltiazem.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Diltiazem.Approved, Investigational
EpirizoleThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Epirizole.Approved
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Diltiazem.Approved
EpoprostenolEpoprostenol may increase the hypotensive activities of Diltiazem.Approved
EprosartanDiltiazem may increase the hypotensive activities of Eprosartan.Approved
EquileninThe metabolism of Equilenin can be decreased when combined with Diltiazem.Experimental
EquilinThe metabolism of Equilin can be decreased when combined with Diltiazem.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Diltiazem.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Diltiazem.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Diltiazem.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Diltiazem.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Diltiazem.Approved, Investigational
ErtugliflozinThe serum concentration of Ertugliflozin can be increased when it is combined with Diltiazem.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
EsatenololDiltiazem may increase the hypotensive activities of Esatenolol.Experimental
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Diltiazem.Approved, Investigational
EsmololDiltiazem may increase the hypotensive activities of Esmolol.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Diltiazem.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Diltiazem.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol acetateThe metabolism of Estradiol acetate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol benzoateThe metabolism of Estradiol benzoate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol cypionateThe metabolism of Estradiol cypionate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol dienanthateThe metabolism of Estradiol dienanthate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
Estradiol valerateThe metabolism of Estradiol valerate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Diltiazem.Approved, Investigational
EstriolThe serum concentration of Estriol can be increased when it is combined with Diltiazem.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Diltiazem.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Diltiazem.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Diltiazem.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Diltiazem.Approved, Investigational
Etacrynic acidThe risk or severity of adverse effects can be increased when Diltiazem is combined with Etacrynic acid.Approved, Investigational
EthanolThe metabolism of Ethanol can be decreased when combined with Diltiazem.Approved
EthenzamideThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Ethenzamide.Experimental
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Diltiazem.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Diltiazem.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be decreased when combined with Diltiazem.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Diltiazem.Approved, Illicit
EthynodiolThe metabolism of Ethynodiol can be decreased when combined with Diltiazem.Experimental
Ethynodiol diacetateThe metabolism of Ethynodiol diacetate can be decreased when combined with Diltiazem.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Diltiazem.Approved
EtodolacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Etofenamate.Approved, Investigational
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Diltiazem.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Diltiazem.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Diltiazem.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Diltiazem.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Diltiazem.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Diltiazem.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Diltiazem.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Diltiazem.Approved, Investigational
FelbamateThe metabolism of Felbamate can be decreased when combined with Diltiazem.Approved
FelbinacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Felbinac.Experimental
FelodipineThe metabolism of Felodipine can be decreased when combined with Diltiazem.Approved, Investigational
FenbufenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Fenbufen.Approved
FendilineThe metabolism of Fendiline can be decreased when combined with Diltiazem.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Diltiazem.Approved
FenoldopamDiltiazem may increase the hypotensive activities of Fenoldopam.Approved
FenoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Fenoprofen.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Diltiazem.Approved, Illicit, Investigational, Vet Approved
FentiazacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Fentiazac.Experimental
FenticonazoleThe therapeutic efficacy of Fenticonazole can be increased when used in combination with Diltiazem.Experimental
FeprazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Feprazone.Experimental
Ferulic acidDiltiazem may increase the hypotensive activities of Ferulic acid.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diltiazem.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Diltiazem.Approved, Investigational
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Diltiazem.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Diltiazem.Approved, Investigational
FinasterideThe metabolism of Finasteride can be decreased when combined with Diltiazem.Approved
FingolimodThe risk or severity of bradycardia can be increased when Diltiazem is combined with Fingolimod.Approved, Investigational
FirocoxibThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Firocoxib.Experimental, Vet Approved
Fish oilThe metabolism of Fish oil can be decreased when combined with Diltiazem.Approved, Nutraceutical
FlibanserinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Flibanserin.Approved, Investigational
FloctafenineThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Floctafenine.Approved, Withdrawn
Fluciclovine (18F)The serum concentration of Fluciclovine (18F) can be increased when it is combined with Diltiazem.Approved
FluconazoleThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.Approved, Investigational
FludrocortisoneThe metabolism of Fludrocortisone can be decreased when combined with Diltiazem.Approved, Investigational
FluindioneThe metabolism of Fluindione can be decreased when combined with Diltiazem.Approved, Investigational
FlumethasoneThe metabolism of Flumethasone can be decreased when combined with Diltiazem.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Diltiazem.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Diltiazem.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Diltiazem.Approved, Illicit
FlunixinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Flunixin.Vet Approved
FlunoxaprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Flunoxaprofen.Experimental
Fluocinolone AcetonideThe metabolism of Fluocinolone Acetonide can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
FluocinonideThe metabolism of Fluocinonide can be decreased when combined with Diltiazem.Approved, Investigational
FluocortoloneThe metabolism of Fluocortolone can be decreased when combined with Diltiazem.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Diltiazem.Approved, Investigational
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Diltiazem.Approved, Vet Approved
FlupentixolThe risk or severity of hypotension can be increased when Flupentixol is combined with Diltiazem.Approved, Investigational, Withdrawn
FluphenazineThe serum concentration of Diltiazem can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe metabolism of Fluprednidene can be decreased when combined with Diltiazem.Approved, Withdrawn
FluprednisoloneThe metabolism of Fluprednisolone can be decreased when combined with Diltiazem.Approved
FlurandrenolideThe metabolism of Flurandrenolide can be decreased when combined with Diltiazem.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
FlurbiprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Flurbiprofen.Approved, Investigational
FluspirileneThe metabolism of Fluspirilene can be decreased when combined with Diltiazem.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Diltiazem.Approved, Investigational
FluticasoneThe metabolism of Fluticasone can be decreased when combined with Diltiazem.Approved, Experimental, Investigational
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Diltiazem.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Diltiazem.Approved
FlutrimazoleThe therapeutic efficacy of Flutrimazole can be increased when used in combination with Diltiazem.Experimental
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Diltiazem.Approved
FluvoxamineThe serum concentration of Diltiazem can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Diltiazem.Approved
FosaprepitantThe serum concentration of Fosaprepitant can be increased when it is combined with Diltiazem.Approved
FosinoprilDiltiazem may increase the hypotensive activities of Fosinopril.Approved
FosinoprilatDiltiazem may increase the hypotensive activities of Fosinoprilat.Experimental
FosnetupitantThe metabolism of Fosnetupitant can be decreased when combined with Diltiazem.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Diltiazem.Approved, Investigational
FostamatinibFostamatinib may increase the antihypertensive activities of Diltiazem.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Diltiazem.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Diltiazem.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe metabolism of Gabapentin can be decreased when combined with Diltiazem.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Diltiazem.Approved
GallamineDiltiazem may increase the neuromuscular blocking activities of Gallamine.Experimental
Gallamine TriethiodideDiltiazem may increase the neuromuscular blocking activities of Gallamine Triethiodide.Approved
GallopamilThe metabolism of Gallopamil can be decreased when combined with Diltiazem.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Diltiazem.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Diltiazem.Approved
GenisteinThe serum concentration of Diltiazem can be increased when it is combined with Genistein.Investigational
GestodeneThe metabolism of Gestodene can be decreased when combined with Diltiazem.Approved, Investigational
GestrinoneThe metabolism of Gestrinone can be decreased when combined with Diltiazem.Approved
GitoformateDiltiazem may increase the atrioventricular blocking (AV block) activities of Gitoformate.Experimental
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Diltiazem.Approved, Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Diltiazem.Approved, Investigational
GlyburideThe metabolism of Glyburide can be decreased when combined with Diltiazem.Approved
GlycerinThe serum concentration of Diltiazem can be increased when it is combined with Glycerin.Approved, Investigational
Gramicidin DThe serum concentration of Gramicidin D can be increased when it is combined with Diltiazem.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Diltiazem.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Diltiazem.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
GuacetisalDiltiazem may increase the anticoagulant activities of Guacetisal.Experimental
GuanabenzDiltiazem may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Diltiazem.Approved
GuanazodineDiltiazem may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineDiltiazem may increase the hypotensive activities of Guanethidine.Approved
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Diltiazem.Approved, Investigational
GuanoclorDiltiazem may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzDiltiazem may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanDiltiazem may increase the hypotensive activities of Guanoxan.Experimental
HalcinonideThe metabolism of Halcinonide can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Diltiazem.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Diltiazem.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Diltiazem.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Diltiazem.Experimental
HE3286The metabolism of HE3286 can be decreased when combined with Diltiazem.Investigational
HexamethoniumDiltiazem may increase the hypotensive activities of Hexamethonium.Experimental
HexobarbitalHexobarbital may increase the hypotensive activities of Diltiazem.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Diltiazem.Approved, Investigational
HM-30181The serum concentration of Diltiazem can be increased when it is combined with HM-30181.Experimental
HycanthoneThe serum concentration of Diltiazem can be increased when it is combined with Hycanthone.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Diltiazem.Experimental
HydralazineHydralazine may increase the hypotensive activities of Diltiazem.Approved
HydrochlorothiazideDiltiazem may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Diltiazem.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone aceponateThe metabolism of Hydrocortisone aceponate can be decreased when combined with Diltiazem.Experimental, Vet Approved
Hydrocortisone acetateThe metabolism of Hydrocortisone acetate can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone butyrateThe metabolism of Hydrocortisone butyrate can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone cypionateThe metabolism of Hydrocortisone cypionate can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone phosphateThe metabolism of Hydrocortisone phosphate can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone probutateThe metabolism of Hydrocortisone probutate can be decreased when combined with Diltiazem.Approved, Vet Approved
Hydrocortisone succinateThe metabolism of Hydrocortisone succinate can be decreased when combined with Diltiazem.Approved
Hydrocortisone valerateThe metabolism of Hydrocortisone valerate can be decreased when combined with Diltiazem.Approved, Vet Approved
HydroflumethiazideDiltiazem may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Diltiazem.Approved, Illicit
HydroxychloroquineThe serum concentration of Diltiazem can be increased when it is combined with Hydroxychloroquine.Approved
HydroxyprogesteroneThe metabolism of Hydroxyprogesterone can be decreased when combined with Diltiazem.Experimental
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Diltiazem.Approved, Investigational
HydroxyureaThe serum concentration of Hydroxyurea can be increased when it is combined with Diltiazem.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Diltiazem.Approved
IbuprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Ibuprofen.Approved
IbuproxamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Ibuproxam.Withdrawn
IcosapentThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Icosapent.Approved, Nutraceutical
IcotinibThe metabolism of Icotinib can be decreased when combined with Diltiazem.Approved, Investigational
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Diltiazem.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Diltiazem resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Diltiazem.Approved
IloprostIloprost may increase the hypotensive activities of Diltiazem.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Diltiazem.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Diltiazem.Approved, Investigational
ImidaprilDiltiazem may increase the hypotensive activities of Imidapril.Investigational
Imidazole salicylateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Imidazole salicylate.Experimental
ImipramineThe risk or severity of hypotension can be increased when Imipramine is combined with Diltiazem.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Diltiazem.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Diltiazem.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Diltiazem.Approved
IndenololDiltiazem may increase the hypotensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Diltiazem can be decreased when combined with Indinavir.Approved
IndobufenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Indobufen.Investigational
IndomethacinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Indomethacin.Approved, Investigational
IndoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Indoprofen.Withdrawn
IndoraminThe risk or severity of hypotension can be increased when Indoramin is combined with Diltiazem.Withdrawn
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Diltiazem.Approved, Investigational
IpecacThe metabolism of Ipecac can be decreased when combined with Diltiazem.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium can be decreased when combined with Diltiazem.Approved
IproniazidIproniazid may increase the hypotensive activities of Diltiazem.Withdrawn
IrbesartanDiltiazem may increase the hypotensive activities of Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Diltiazem.Approved, Investigational
IsavuconazoleThe serum concentration of Isavuconazole can be increased when it is combined with Diltiazem.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Diltiazem.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Diltiazem.Approved
IsoconazoleThe therapeutic efficacy of Isoconazole can be increased when used in combination with Diltiazem.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Diltiazem.Approved, Vet Approved
IsoniazidThe metabolism of Diltiazem can be decreased when combined with Isoniazid.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Diltiazem.Approved, Investigational
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Diltiazem.Approved
IsoxicamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Isoxicam.Withdrawn
IsoxsuprineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe metabolism of Isradipine can be decreased when combined with Diltiazem.Approved, Investigational
ItraconazoleThe metabolism of Diltiazem can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Diltiazem.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Diltiazem.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
IvosidenibThe metabolism of Ivosidenib can be decreased when combined with Diltiazem.Approved, Investigational
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Diltiazem.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Diltiazem.Approved, Investigational
KebuzoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Kebuzone.Experimental
KetamineThe metabolism of Ketamine can be decreased when combined with Diltiazem.Approved, Vet Approved
KetanserinKetanserin may increase the hypotensive activities of Diltiazem.Investigational
KetazolamThe metabolism of Ketazolam can be decreased when combined with Diltiazem.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Diltiazem.Approved, Investigational
KetoconazoleThe metabolism of Diltiazem can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Ketoprofen.Approved, Vet Approved
KetorolacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Ketorolac.Approved
LabetalolDiltiazem may increase the hypotensive activities of Labetalol.Approved
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Diltiazem.Approved, Investigational
LacosamideDiltiazem may increase the atrioventricular blocking (AV block) activities of Lacosamide.Approved
LactitolThe therapeutic efficacy of Lactitol can be decreased when used in combination with Diltiazem.Investigational
LactuloseThe therapeutic efficacy of Lactulose can be decreased when used in combination with Diltiazem.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Diltiazem.Approved, Investigational
LamotrigineThe metabolism of Lamotrigine can be decreased when combined with Diltiazem.Approved, Investigational
Lanatoside CDiltiazem may increase the atrioventricular blocking (AV block) activities of Lanatoside C.Experimental
LandiololDiltiazem may increase the hypotensive activities of Landiolol.Investigational
LaniquidarThe serum concentration of Diltiazem can be increased when it is combined with Laniquidar.Investigational
LanreotideDiltiazem may increase the bradycardic activities of Lanreotide.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Diltiazem.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Diltiazem.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Diltiazem.Investigational
LatanoprostDiltiazem may increase the hypotensive activities of Latanoprost.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Diltiazem.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Diltiazem.Approved, Investigational
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Diltiazem.Approved, Investigational
LetermovirThe serum concentration of Letermovir can be increased when it is combined with Diltiazem.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Diltiazem.Approved, Investigational
LeuprolideThe metabolism of Leuprolide can be decreased when combined with Diltiazem.Approved, Investigational
LevetiracetamThe metabolism of Levetiracetam can be decreased when combined with Diltiazem.Approved, Investigational
LevobetaxololDiltiazem may increase the hypotensive activities of Levobetaxolol.Approved, Investigational
LevobunololDiltiazem may increase the hypotensive activities of Levobunolol.Approved
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Diltiazem.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Diltiazem.Approved
LevodopaDiltiazem may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Diltiazem.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Diltiazem.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Diltiazem.Approved, Investigational
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Diltiazem.Approved, Investigational
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Diltiazem.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Diltiazem.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Diltiazem.Approved, Vet Approved
LidoflazineThe metabolism of Lidoflazine can be decreased when combined with Diltiazem.Experimental
LinaclotideThe therapeutic efficacy of Linaclotide can be decreased when used in combination with Diltiazem.Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Diltiazem.Approved
LinezolidLinezolid may increase the hypotensive activities of Diltiazem.Approved, Investigational
LinsidomineDiltiazem may increase the hypotensive activities of Linsidomine.Experimental
LiothyronineThe metabolism of Liothyronine can be decreased when combined with Diltiazem.Approved, Vet Approved
LiotrixThe metabolism of Liotrix can be decreased when combined with Diltiazem.Approved
LisinoprilDiltiazem may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Diltiazem.Approved, Investigational
Lithium cationDiltiazem may increase the neurotoxic activities of Lithium cation.Experimental
LobeglitazoneThe metabolism of Lobeglitazone can be decreased when combined with Diltiazem.Approved, Investigational
LofexidineDiltiazem may increase the hypotensive activities of Lofexidine.Approved, Investigational
LomerizineThe metabolism of Lomerizine can be decreased when combined with Diltiazem.Experimental
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Diltiazem.Approved, Investigational
LonafarnibThe serum concentration of Diltiazem can be increased when it is combined with Lonafarnib.Investigational
LonazolacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Lonazolac.Experimental
LoperamideThe metabolism of Loperamide can be decreased when combined with Diltiazem.Approved
LopinavirThe metabolism of Diltiazem can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Diltiazem.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Diltiazem.Approved
LornoxicamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Lornoxicam.Approved, Investigational
LorpiprazoleThe serum concentration of Diltiazem can be increased when it is combined with Lorpiprazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Diltiazem.Approved
LoteprednolThe metabolism of Loteprednol can be decreased when combined with Diltiazem.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Diltiazem.Approved, Investigational
LoxapineThe serum concentration of Diltiazem can be increased when it is combined with Loxapine.Approved
LoxoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Loxoprofen.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Diltiazem.Approved, Investigational
LucinactantDiltiazem may increase the bradycardic activities of Lucinactant.Approved, Investigational
LuliconazoleThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Diltiazem can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Diltiazem.Approved
LumiracoxibThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Lumiracoxib.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Diltiazem.Approved, Investigational
LusutrombopagThe serum concentration of Lusutrombopag can be increased when it is combined with Diltiazem.Approved, Investigational
LynestrenolThe metabolism of Lynestrenol can be decreased when combined with Diltiazem.Approved, Investigational
Lysergic Acid DiethylamideThe metabolism of Lysergic Acid Diethylamide can be decreased when combined with Diltiazem.Illicit, Investigational, Withdrawn
MacimorelinThe metabolism of Macimorelin can be decreased when combined with Diltiazem.Approved, Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Diltiazem.Approved
Magnesium carbonateThe therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Diltiazem.Approved, Investigational
Magnesium citrateThe therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Diltiazem.Approved
Magnesium hydroxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium oxide.Approved
Magnesium peroxideThe therapeutic efficacy of Magnesium peroxide can be decreased when used in combination with Diltiazem.Experimental
Magnesium salicylateThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium salicylate.Approved
Magnesium sulfateThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
ManidipineThe metabolism of Manidipine can be decreased when combined with Diltiazem.Approved, Investigational
MannitolThe therapeutic efficacy of Mannitol can be decreased when used in combination with Diltiazem.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Diltiazem.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Diltiazem.Withdrawn
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Diltiazem.Approved, Vet Approved
MecamylamineMecamylamine may increase the hypotensive activities of Diltiazem.Approved, Investigational
Meclofenamic acidThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Meclofenamic acid.Approved, Vet Approved
Medical CannabisThe metabolism of Medical Cannabis can be decreased when combined with Diltiazem.Experimental, Investigational
MedrogestoneThe metabolism of Medrogestone can be decreased when combined with Diltiazem.Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Diltiazem.Approved, Investigational
MedrysoneThe metabolism of Medrysone can be decreased when combined with Diltiazem.Approved
Mefenamic acidThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Mefenamic acid.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Diltiazem.Approved, Investigational
Megestrol acetateThe metabolism of Megestrol acetate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
MelengestrolThe metabolism of Melengestrol can be decreased when combined with Diltiazem.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Diltiazem.Approved, Vet Approved
MelphalanThe serum concentration of Melphalan can be increased when it is combined with Diltiazem.Approved
MentholThe metabolism of Menthol can be decreased when combined with Diltiazem.Approved
MepindololDiltiazem may increase the hypotensive activities of Mepindolol.Experimental
MeprednisoneThe metabolism of Meprednisone can be decreased when combined with Diltiazem.Approved, Investigational
MesalazineDiltiazem may increase the anticoagulant activities of Mesalazine.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Diltiazem.Approved
MetamizoleThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Metamizole.Approved, Investigational, Withdrawn
MetergolineThe metabolism of Metergoline can be decreased when combined with Diltiazem.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Diltiazem.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Diltiazem.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Methazolamide.Approved
MethohexitalMethohexital may increase the hypotensive activities of Diltiazem.Approved
MethoserpidineDiltiazem may increase the hypotensive activities of Methoserpidine.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Diltiazem.Approved
MethotrimeprazineThe risk or severity of hypotension can be increased when Methotrimeprazine is combined with Diltiazem.Approved, Investigational
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Diltiazem.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Diltiazem.Approved
Methyl celluloseThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Diltiazem.Approved
Methyl salicylateDiltiazem may increase the anticoagulant activities of Methyl salicylate.Approved, Vet Approved
MethyldopaDiltiazem may increase the hypotensive activities of Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Diltiazem.Approved, Investigational
MethylergometrineThe metabolism of Methylergometrine can be decreased when combined with Diltiazem.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Diltiazem.Approved, Investigational
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Diltiazem.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Diltiazem.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Diltiazem.Approved
MethysergideThe metabolism of Methysergide can be decreased when combined with Diltiazem.Approved
MetildigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Metildigoxin.Experimental
MetipranololDiltiazem may increase the hypotensive activities of Metipranolol.Approved
MetocurineDiltiazem may increase the neuromuscular blocking activities of Metocurine.Approved
Metocurine IodideDiltiazem may increase the neuromuscular blocking activities of Metocurine Iodide.Approved, Withdrawn
MetolazoneDiltiazem may increase the hypotensive activities of Metolazone.Approved
MetoprololDiltiazem may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Diltiazem.Approved
MetyrosineDiltiazem may increase the hypotensive activities of Metyrosine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Diltiazem.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Diltiazem.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be decreased when combined with Diltiazem.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Diltiazem.Approved, Illicit
MidecamycinThe metabolism of Midecamycin can be decreased when combined with Diltiazem.Approved
MidodrineDiltiazem may increase the bradycardic activities of Midodrine.Approved
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Diltiazem.Approved, Investigational
MifepristoneThe serum concentration of Diltiazem can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineMinaprine may increase the hypotensive activities of Diltiazem.Approved
Mineral oilThe therapeutic efficacy of Mineral oil can be decreased when used in combination with Diltiazem.Approved, Vet Approved
MinoxidilMinoxidil may increase the hypotensive activities of Diltiazem.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Diltiazem.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Diltiazem.Investigational
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Diltiazem.Approved
MitomycinThe serum concentration of Mitomycin can be increased when it is combined with Diltiazem.Approved
MitotaneThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Diltiazem can be increased when it is combined with Mitoxantrone.Approved, Investigational
MivacuriumDiltiazem may increase the neuromuscular blocking activities of Mivacurium.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Diltiazem.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Diltiazem.Approved, Investigational
MoexiprilDiltiazem may increase the hypotensive activities of Moexipril.Approved
MofebutazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Mofebutazone.Experimental
MolsidomineMolsidomine may increase the hypotensive activities of Diltiazem.Approved, Investigational
MometasoneThe metabolism of Mometasone can be decreased when combined with Diltiazem.Approved, Vet Approved
Mometasone furoateThe metabolism of Mometasone furoate can be decreased when combined with Diltiazem.Approved, Vet Approved
MonensinThe serum concentration of Diltiazem can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Diltiazem.Approved
MorniflumateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Morniflumate.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Diltiazem.Approved, Investigational
MoxidectinThe serum concentration of Moxidectin can be increased when it is combined with Diltiazem.Approved, Investigational, Vet Approved
MoxonidineMoxonidine may increase the hypotensive activities of Diltiazem.Approved, Investigational
MuzolimineDiltiazem may increase the hypotensive activities of Muzolimine.Experimental
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Diltiazem.Approved, Investigational
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Diltiazem.Approved, Investigational
NabiximolsThe metabolism of Nabiximols can be decreased when combined with Diltiazem.Approved, Investigational
NabumetoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Nabumetone.Approved
NadololDiltiazem may increase the hypotensive activities of Nadolol.Approved
NafcillinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Nafcillin.Approved, Investigational
NaftopidilThe metabolism of Naftopidil can be decreased when combined with Diltiazem.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Diltiazem.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Diltiazem.Approved, Vet Approved
NaltrexoneThe metabolism of Naltrexone can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
NaproxenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Naproxen.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Diltiazem.Approved, Investigational
NebivololDiltiazem may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneThe risk or severity of hypotension can be increased when Nefazodone is combined with Diltiazem.Approved, Withdrawn
NelfinavirThe metabolism of Diltiazem can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Neostigmine can be increased when it is combined with Diltiazem.Approved, Vet Approved
NepafenacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Nepafenac.Approved, Investigational
NeratinibThe metabolism of Neratinib can be decreased when combined with Diltiazem.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nesiritide.Approved, Investigational
NetoglitazoneThe metabolism of Netoglitazone can be decreased when combined with Diltiazem.Experimental
NetupitantThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Diltiazem can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Diltiazem.Withdrawn
NicardipineThe risk or severity of hypotension can be increased when Nicardipine is combined with Diltiazem.Approved, Investigational
NicergolineThe metabolism of Nicergoline can be decreased when combined with Diltiazem.Approved, Investigational
NicorandilNicorandil may increase the hypotensive activities of Diltiazem.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Diltiazem.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Diltiazem.Approved
NifenazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Nifenazone.Experimental
Niflumic AcidThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Niflumic Acid.Approved
NigericinThe serum concentration of Diltiazem can be increased when it is combined with Nigericin.Experimental
NiguldipineThe risk or severity of hypotension can be increased when Niguldipine is combined with Diltiazem.Experimental
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Diltiazem.Approved, Investigational
NiludipineThe metabolism of Niludipine can be decreased when combined with Diltiazem.Experimental
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Diltiazem.Approved, Investigational
NimesulideThe metabolism of Nimesulide can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Diltiazem.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Diltiazem.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Diltiazem.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Diltiazem.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Diltiazem.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Diltiazem.Approved
NitroaspirinDiltiazem may increase the anticoagulant activities of Nitroaspirin.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nitroglycerin.Approved, Investigational
NitroprussideDiltiazem may increase the hypotensive activities of Nitroprusside.Approved, Investigational
Nitrous acidThe risk or severity of adverse effects can be increased when Nitrous acid is combined with Diltiazem.Approved, Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Diltiazem.Approved
NomegestrolThe metabolism of Nomegestrol can be decreased when combined with Diltiazem.Approved
Nomegestrol acetateThe metabolism of Nomegestrol acetate can be decreased when combined with Diltiazem.Approved, Investigational
NorelgestrominThe metabolism of Norelgestromin can be decreased when combined with Diltiazem.Approved, Investigational
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Diltiazem.Approved
NorethynodrelThe metabolism of Norethynodrel can be decreased when combined with Diltiazem.Approved
NorgestimateThe metabolism of Norgestimate can be decreased when combined with Diltiazem.Approved, Investigational
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Diltiazem.Approved
NorgestrienoneThe metabolism of Norgestrienone can be decreased when combined with Diltiazem.Experimental
NortriptylineThe risk or severity of hypotension can be increased when Nortriptyline is combined with Diltiazem.Approved
NS-398The therapeutic efficacy of Diltiazem can be decreased when used in combination with NS-398.Experimental
NylidrinThe metabolism of Nylidrin can be decreased when combined with Diltiazem.Approved
ObinutuzumabDiltiazem may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Diltiazem.Withdrawn
OctreotideThe serum concentration of Octreotide can be increased when it is combined with Diltiazem.Approved, Investigational
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Diltiazem.Investigational
OlanzapineThe risk or severity of hypotension can be increased when Olanzapine is combined with Diltiazem.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Diltiazem.Approved
OleandrinDiltiazem may increase the atrioventricular blocking (AV block) activities of Oleandrin.Experimental, Investigational
OlmesartanOlmesartan may increase the hypotensive activities of Diltiazem.Approved, Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Diltiazem.Approved
OlsalazineDiltiazem may increase the anticoagulant activities of Olsalazine.Approved
OmapatrilatDiltiazem may increase the hypotensive activities of Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Diltiazem.Approved, Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
OmoconazoleThe therapeutic efficacy of Omoconazole can be increased when used in combination with Diltiazem.Experimental
OndansetronThe metabolism of Ondansetron can be decreased when combined with Diltiazem.Approved
ONT-093The serum concentration of Diltiazem can be increased when it is combined with ONT-093.Investigational
OpiumThe metabolism of Opium can be decreased when combined with Diltiazem.Approved, Illicit
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Diltiazem.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Diltiazem.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Diltiazem.Approved, Investigational
OtiloniumThe metabolism of Otilonium can be decreased when combined with Diltiazem.Experimental, Investigational
OuabainDiltiazem may increase the atrioventricular blocking (AV block) activities of Ouabain.Approved
OxaprozinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Oxaprozin.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Diltiazem.Approved
OxiconazoleThe therapeutic efficacy of Oxiconazole can be increased when used in combination with Diltiazem.Approved
OxprenololDiltiazem may increase the hypotensive activities of Oxprenolol.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Diltiazem.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
OxyphenbutazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Oxyphenbutazone.Approved, Withdrawn
OxyphenisatinThe therapeutic efficacy of Oxyphenisatin can be decreased when used in combination with Diltiazem.Investigational, Withdrawn
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Diltiazem.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Diltiazem.Approved, Investigational
PaliperidoneThe risk or severity of hypotension can be increased when Paliperidone is combined with Diltiazem.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Diltiazem.Approved, Investigational
PancuroniumDiltiazem may increase the neuromuscular blocking activities of Pancuronium.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Diltiazem.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Diltiazem.Approved
PapaverineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Papaverine.Approved, Investigational
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Diltiazem.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Diltiazem.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Diltiazem.Approved
PargylinePargyline may increase the hypotensive activities of Diltiazem.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Diltiazem.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Diltiazem.Approved, Investigational
ParoxetineThe serum concentration of Diltiazem can be increased when it is combined with Paroxetine.Approved, Investigational
PasireotideDiltiazem may increase the bradycardic activities of Pasireotide.Approved
Patent BlueThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Patent Blue.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Diltiazem.Approved
PenbutololDiltiazem may increase the hypotensive activities of Penbutolol.Approved, Investigational
PenfluridolThe metabolism of Penfluridol can be decreased when combined with Diltiazem.Experimental
PentaerithritylThe therapeutic efficacy of Pentaerithrityl can be decreased when used in combination with Diltiazem.Experimental
PentamidineThe metabolism of Pentamidine can be decreased when combined with Diltiazem.Approved, Investigational
PentazocineThe serum concentration of Pentazocine can be increased when it is combined with Diltiazem.Approved, Vet Approved
PentobarbitalPentobarbital may increase the hypotensive activities of Diltiazem.Approved, Investigational, Vet Approved
PentoliniumDiltiazem may increase the hypotensive activities of Pentolinium.Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Diltiazem.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Diltiazem.Approved, Investigational
PerindoprilDiltiazem may increase the hypotensive activities of Perindopril.Approved
PerindoprilatDiltiazem may increase the hypotensive activities of Perindoprilat.Experimental
PermethrinThe metabolism of Permethrin can be decreased when combined with Diltiazem.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Diltiazem.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Diltiazem.Approved
PeruvosideDiltiazem may increase the atrioventricular blocking (AV block) activities of Peruvoside.Experimental
PethidineThe metabolism of Pethidine can be decreased when combined with Diltiazem.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Diltiazem.Withdrawn
PhenelzinePhenelzine may increase the hypotensive activities of Diltiazem.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Diltiazem.Withdrawn
PhenobarbitalPhenobarbital may increase the hypotensive activities of Diltiazem.Approved, Investigational
PhenolphthaleinThe therapeutic efficacy of Phenolphthalein can be decreased when used in combination with Diltiazem.Approved, Withdrawn
PhenothiazineThe serum concentration of Phenothiazine can be increased when it is combined with Diltiazem.Vet Approved
PhenoxybenzamineThe risk or severity of hypotension can be increased when Phenoxybenzamine is combined with Diltiazem.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Diltiazem.Withdrawn
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Diltiazem.Approved, Investigational
PhentolamineThe risk or severity of hypotension can be increased when Phentolamine is combined with Diltiazem.Approved
Phenyl aminosalicylateDiltiazem may increase the anticoagulant activities of Phenyl aminosalicylate.Approved
PhenylbutazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Phenylbutazone.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Diltiazem.Approved, Vet Approved
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Diltiazem.Approved, Investigational
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Diltiazem.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Diltiazem.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Diltiazem.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Diltiazem.Approved
PinaveriumThe metabolism of Pinaverium can be decreased when combined with Diltiazem.Approved
PindololDiltiazem may increase the hypotensive activities of Pindolol.Approved, Investigational
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Diltiazem.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Diltiazem.Approved, Investigational
PipecuroniumDiltiazem may increase the neuromuscular blocking activities of Pipecuronium.Approved
PiperaquineThe metabolism of Piperaquine can be decreased when combined with Diltiazem.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Diltiazem.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Diltiazem.Approved
PiroxicamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Piroxicam.Approved, Investigational
PirprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Pirprofen.Experimental
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Diltiazem.Approved
PitolisantThe serum concentration of Diltiazem can be decreased when it is combined with Pitolisant.Approved, Investigational
PivhydrazinePivhydrazine may increase the hypotensive activities of Diltiazem.Withdrawn
PizotifenThe risk or severity of hypotension can be increased when Pizotifen is combined with Diltiazem.Approved
Plantago seedThe therapeutic efficacy of Plantago seed can be decreased when used in combination with Diltiazem.Approved, Investigational
PlecanatideThe therapeutic efficacy of Plecanatide can be decreased when used in combination with Diltiazem.Approved, Investigational
PodofiloxThe metabolism of Podofilox can be decreased when combined with Diltiazem.Approved
PolycarbophilThe therapeutic efficacy of Polycarbophil can be decreased when used in combination with Diltiazem.Approved
Polyethylene glycolThe therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Diltiazem.Approved, Vet Approved
PolythiazideDiltiazem may increase the hypotensive activities of Polythiazide.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Diltiazem.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Diltiazem.Approved, Investigational
Poractant alfaDiltiazem may increase the bradycardic activities of Poractant alfa.Approved
PosaconazoleThe metabolism of Diltiazem can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium acetateThe therapeutic efficacy of Potassium acetate can be decreased when used in combination with Diltiazem.Approved, Investigational
PractololDiltiazem may increase the hypotensive activities of Practolol.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Diltiazem.Approved, Investigational
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Diltiazem.Approved, Investigational
PranoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Pranoprofen.Experimental, Investigational
PrasteroneThe metabolism of Prasterone can be decreased when combined with Diltiazem.Approved, Investigational, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Diltiazem resulting in a loss in efficacy.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Diltiazem.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Diltiazem.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
PrazosinThe risk or severity of hypotension can be increased when Prazosin is combined with Diltiazem.Approved
PrednicarbateThe metabolism of Prednicarbate can be decreased when combined with Diltiazem.Approved, Investigational
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Diltiazem.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Diltiazem.Approved, Vet Approved
PrednylideneThe metabolism of Prednylidene can be decreased when combined with Diltiazem.Experimental
PregabalinThe metabolism of Pregabalin can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
PregnenoloneThe metabolism of Pregnenolone can be decreased when combined with Diltiazem.Approved, Experimental, Investigational
PrenylamineThe metabolism of Prenylamine can be decreased when combined with Diltiazem.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Diltiazem.Approved
PrimidonePrimidone may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Diltiazem.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Diltiazem.Approved, Vet Approved
ProglumetacinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Proglumetacin.Experimental
ProguanilThe metabolism of Proguanil can be decreased when combined with Diltiazem.Approved
PromazineThe risk or severity of hypotension can be increased when Promazine is combined with Diltiazem.Approved, Vet Approved
PromegestoneThe metabolism of Promegestone can be decreased when combined with Diltiazem.Experimental
PromethazineThe serum concentration of Diltiazem can be increased when it is combined with Promethazine.Approved, Investigational
PropacetamolThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Propacetamol.Approved, Investigational
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Diltiazem.Approved
PropericiazineThe risk or severity of hypotension can be increased when Propericiazine is combined with Diltiazem.Approved, Investigational
PropiomazineThe risk or severity of hypotension can be increased when Propiomazine is combined with Diltiazem.Approved
PropiverineThe risk or severity of hypotension can be increased when Propiverine is combined with Diltiazem.Approved, Investigational
PropofolThe metabolism of Propofol can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
PropranololDiltiazem may increase the hypotensive activities of Propranolol.Approved, Investigational
PropyphenazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Propyphenazone.Experimental
ProquazoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Proquazone.Experimental
ProscillaridinDiltiazem may increase the atrioventricular blocking (AV block) activities of Proscillaridin.Experimental
ProtriptylineThe serum concentration of Diltiazem can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Diltiazem.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Diltiazem.Approved, Investigational
QuazepamThe metabolism of Quazepam can be decreased when combined with Diltiazem.Approved, Illicit
QuercetinThe serum concentration of Diltiazem can be increased when it is combined with Quercetin.Experimental, Investigational
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Diltiazem.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Diltiazem.Approved, Investigational
QuinaprilDiltiazem may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinaprilatDiltiazem may increase the hypotensive activities of Quinaprilat.Experimental
QuingestanolThe metabolism of Quingestanol can be decreased when combined with Diltiazem.Experimental
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Diltiazem.Approved, Investigational
QuinineThe metabolism of Diltiazem can be increased when combined with Quinine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Diltiazem.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Diltiazem.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Diltiazem.Approved, Investigational
RamiprilRamipril may increase the hypotensive activities of Diltiazem.Approved
RamiprilatDiltiazem may increase the hypotensive activities of Ramiprilat.Experimental
RanitidineThe serum concentration of Diltiazem can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.Approved, Investigational
RapacuroniumDiltiazem may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RasagilineRasagiline may increase the hypotensive activities of Diltiazem.Approved
RavuconazoleThe therapeutic efficacy of Ravuconazole can be increased when used in combination with Diltiazem.Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Diltiazem.Approved, Investigational
RegorafenibRegorafenib may increase the bradycardic activities of Diltiazem.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Diltiazem.Approved
RemikirenRemikiren may increase the hypotensive activities of Diltiazem.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Diltiazem.Approved, Investigational
RescinnamineDiltiazem may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe serum concentration of Diltiazem can be increased when it is combined with Reserpine.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Diltiazem.Approved
Reversin 121The serum concentration of Diltiazem can be increased when it is combined with Reversin 121.Experimental
Rhodamine 6GThe serum concentration of Rhodamine 6G can be increased when it is combined with Diltiazem.Experimental
RibociclibThe serum concentration of Ribociclib can be increased when it is combined with Diltiazem.Approved, Investigational
RifabutinThe metabolism of Rifabutin can be decreased when combined with Diltiazem.Approved, Investigational
RifampicinThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.Approved
RifamycinThe metabolism of Diltiazem can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Diltiazem can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Diltiazem.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Diltiazem.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Diltiazem.Approved
RimexoloneThe metabolism of Diltiazem can be increased when combined with Rimexolone.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Diltiazem.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Diltiazem.Approved
RisperidoneDiltiazem may increase the hypotensive activities of Risperidone.Approved, Investigational
RitonavirThe metabolism of Diltiazem can be decreased when combined with Ritonavir.Approved, Investigational
RituximabDiltiazem may increase the hypotensive activities of Rituximab.Approved
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Diltiazem.Approved
RivastigmineDiltiazem may increase the bradycardic activities of Rivastigmine.Approved, Investigational
RivoglitazoneThe metabolism of Rivoglitazone can be decreased when combined with Diltiazem.Experimental, Investigational
RobenacoxibThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Robenacoxib.Experimental, Vet Approved
RocuroniumDiltiazem may increase the neuromuscular blocking activities of Rocuronium.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Diltiazem.Approved, Investigational
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Diltiazem.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Diltiazem.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Diltiazem.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Diltiazem.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Diltiazem.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Diltiazem.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Diltiazem.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Diltiazem.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Diltiazem.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Diltiazem.Approved
SafinamideSafinamide may increase the hypotensive activities of Diltiazem.Approved, Investigational
SafrazineSafrazine may increase the hypotensive activities of Diltiazem.Withdrawn
SalicylamideThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Salicylamide.Approved
Salicylic acidDiltiazem may increase the anticoagulant activities of Salicylic acid.Approved, Investigational, Vet Approved
SalinomycinThe serum concentration of Diltiazem can be increased when it is combined with Salinomycin.Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Diltiazem.Approved
SalsalateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Salsalate.Approved
SaprisartanDiltiazem may increase the hypotensive activities of Saprisartan.Experimental
SaquinavirThe metabolism of Diltiazem can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Diltiazem.Approved
SC-236The therapeutic efficacy of Diltiazem can be decreased when used in combination with SC-236.Experimental, Investigational
SecobarbitalSecobarbital may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Diltiazem.Approved, Investigational, Vet Approved
SeletracetamThe metabolism of Seletracetam can be decreased when combined with Diltiazem.Investigational
SelexipagThe metabolism of Selexipag can be decreased when combined with Diltiazem.Approved
SennosidesThe therapeutic efficacy of Sennosides can be decreased when used in combination with Diltiazem.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Diltiazem.Approved
SertaconazoleThe therapeutic efficacy of Sertaconazole can be increased when used in combination with Diltiazem.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Diltiazem.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Diltiazem.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Diltiazem.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Diltiazem.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Diltiazem.Approved
SiltuximabThe serum concentration of Diltiazem can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Diltiazem.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Diltiazem.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Diltiazem.Approved, Investigational
SitaxentanDiltiazem may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
Sodium phosphate, monobasicThe therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Diltiazem.Approved
Sodium sulfateThe therapeutic efficacy of Sodium sulfate can be decreased when used in combination with Diltiazem.Approved, Vet Approved
Sodium tartrateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Diltiazem.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Diltiazem.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Diltiazem.Approved
SomatostatinThe serum concentration of Somatostatin can be increased when it is combined with Diltiazem.Approved, Investigational
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Diltiazem.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Diltiazem.Approved, Investigational
SorbitolThe therapeutic efficacy of Sorbitol can be decreased when used in combination with Diltiazem.Approved
SotalolDiltiazem may increase the hypotensive activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Diltiazem.Approved, Investigational
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Diltiazem.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Diltiazem.Approved
SpiraprilDiltiazem may increase the hypotensive activities of Spirapril.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Diltiazem can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StanoloneThe serum concentration of Stanolone can be increased when it is combined with Diltiazem.Illicit, Investigational
Stanolone acetateThe serum concentration of Stanolone acetate can be increased when it is combined with Diltiazem.Experimental
StaurosporineThe serum concentration of Diltiazem can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Diltiazem can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Diltiazem.Approved, Investigational
SufentanilThe metabolism of Sufentanil can be decreased when combined with Diltiazem.Approved, Investigational
SulconazoleThe therapeutic efficacy of Sulconazole can be increased when used in combination with Diltiazem.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Diltiazem.Approved
SulfasalazineDiltiazem may increase the anticoagulant activities of Sulfasalazine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Diltiazem.Approved
SulindacThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Sulindac.Approved, Investigational
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Diltiazem.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Diltiazem.Approved, Investigational
SuprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Suprofen.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Diltiazem.Approved, Investigational
SuxibuzoneThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Suxibuzone.Experimental
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Diltiazem.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Diltiazem.Approved
TacrineThe serum concentration of Tacrine can be increased when it is combined with Diltiazem.Investigational, Withdrawn
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Diltiazem.Approved, Investigational
TalinololDiltiazem may increase the hypotensive activities of Talinolol.Investigational
TalniflumateThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Talniflumate.Approved
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Diltiazem.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Diltiazem.Approved, Investigational
TariquidarThe serum concentration of Diltiazem can be increased when it is combined with Tariquidar.Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Diltiazem.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Diltiazem.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Diltiazem.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Diltiazem.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diltiazem.Approved, Investigational
TegaserodThe therapeutic efficacy of Tegaserod can be decreased when used in combination with Diltiazem.Approved, Investigational, Withdrawn
TelaprevirThe metabolism of Diltiazem can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Diltiazem can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Diltiazem can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Diltiazem.Approved, Investigational
TemocaprilDiltiazem may increase the hypotensive activities of Temocapril.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Diltiazem.Approved
TenidapThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tenidap.Experimental
TeniposideThe metabolism of Teniposide can be decreased when combined with Diltiazem.Approved
TenoxicamThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tenoxicam.Approved
TepoxalinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tepoxalin.Vet Approved
TerazosinThe risk or severity of hypotension can be increased when Terazosin is combined with Diltiazem.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved
TerconazoleThe therapeutic efficacy of Terconazole can be increased when used in combination with Diltiazem.Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Diltiazem.Approved, Withdrawn
TergurideThe metabolism of Terguride can be decreased when combined with Diltiazem.Experimental
TerodilineThe metabolism of Terodiline can be decreased when combined with Diltiazem.Experimental
TertatololDiltiazem may increase the hypotensive activities of Tertatolol.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Diltiazem.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Diltiazem.Approved, Investigational
Testosterone cypionateThe metabolism of Testosterone cypionate can be decreased when combined with Diltiazem.Approved
Testosterone enanthateThe metabolism of Testosterone enanthate can be decreased when combined with Diltiazem.Approved
Testosterone propionateThe metabolism of Testosterone propionate can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe metabolism of Testosterone undecanoate can be decreased when combined with Diltiazem.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Diltiazem.Approved, Vet Approved
TetrahydropalmatineThe metabolism of Tetrahydropalmatine can be decreased when combined with Diltiazem.Investigational
TetrandrineThe metabolism of Tetrandrine can be decreased when combined with Diltiazem.Experimental
TezacaftorThe metabolism of Tezacaftor can be decreased when combined with Diltiazem.Approved, Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Diltiazem.Approved, Investigational, Withdrawn
TheophyllineTheophylline may increase the antihypertensive activities of Diltiazem.Approved
ThiamylalThiamylal may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
ThiopentalThiopental may increase the hypotensive activities of Diltiazem.Approved, Vet Approved
ThioproperazineThe risk or severity of hypotension can be increased when Thioproperazine is combined with Diltiazem.Approved
ThioridazineThe risk or severity of hypotension can be increased when Thioridazine is combined with Diltiazem.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Diltiazem.Approved, Investigational
TiagabineThe metabolism of Tiagabine can be decreased when combined with Diltiazem.Approved, Investigational
TianeptineThe metabolism of Tianeptine can be decreased when combined with Diltiazem.Approved, Investigational
Tiaprofenic acidThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tiaprofenic acid.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Diltiazem resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Diltiazem.Approved
TicrynafenDiltiazem may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololDiltiazem may increase the hypotensive activities of Timolol.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Diltiazem.Approved, Investigational
TinoridineThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tinoridine.Investigational
TioconazoleThe therapeutic efficacy of Tioconazole can be increased when used in combination with Diltiazem.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Diltiazem.Approved
TipifarnibThe serum concentration of Diltiazem can be increased when it is combined with Tipifarnib.Investigational
TipranavirThe metabolism of Tipranavir can be decreased when combined with Diltiazem.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Tizanidine.Approved, Investigational
TocilizumabThe serum concentration of Diltiazem can be decreased when it is combined with Tocilizumab.Approved
TocofersolanThe metabolism of Tocofersolan can be decreased when combined with Diltiazem.Approved
TocopherolThe metabolism of Tocopherol can be decreased when combined with Diltiazem.Approved, Investigational
TocopherylquinoneDiltiazem may increase the hypotensive activities of Tocopherylquinone.Experimental, Investigational
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Diltiazem.Approved, Investigational
TolazolineThe risk or severity of hypotension can be increased when Tolazoline is combined with Diltiazem.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Diltiazem.Approved, Withdrawn
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be decreased when combined with Diltiazem.Approved, Investigational
TolmetinThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Tolmetin.Approved
TolonidineDiltiazem may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Diltiazem.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Diltiazem.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Diltiazem.Approved
TopiramateThe serum concentration of Topiramate can be increased when it is combined with Diltiazem.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Diltiazem.Approved, Investigational
TorasemideTorasemide may increase the hypotensive activities of Diltiazem.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Diltiazem.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Diltiazem.Approved, Investigational
TrandolaprilDiltiazem may increase the hypotensive activities of Trandolapril.Approved
TranilastThe metabolism of Tranilast can be decreased when combined with Diltiazem.Approved, Investigational
TranylcypromineTranylcypromine may increase the hypotensive activities of Diltiazem.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Diltiazem.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Diltiazem.Approved
TrazodoneThe risk or severity of hypotension can be increased when Trazodone is combined with Diltiazem.Approved, Investigational
TreprostinilTreprostinil may increase the hypotensive activities of Diltiazem.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Diltiazem.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Diltiazem.Approved, Vet Approved
TriamtereneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Triamterene.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Diltiazem.Approved, Investigational
TrichlormethiazideDiltiazem may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of hypotension can be increased when Trifluoperazine is combined with Diltiazem.Approved, Investigational
TriflupromazineThe serum concentration of Diltiazem can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrilostaneThe metabolism of Trilostane can be decreased when combined with Diltiazem.Approved, Investigational, Vet Approved, Withdrawn
TrimazosinThe risk or severity of hypotension can be increased when Trimazosin is combined with Diltiazem.Experimental
TrimebutineThe metabolism of Trimebutine can be decreased when combined with Diltiazem.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Diltiazem.Approved
TrimethaphanTrimethaphan may increase the hypotensive activities of Diltiazem.Approved, Investigational
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Diltiazem.Approved, Vet Approved
TrimipramineThe risk or severity of hypotension can be increased when Trimipramine is combined with Diltiazem.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Diltiazem.Investigational, Withdrawn
Trolamine salicylateDiltiazem may increase the anticoagulant activities of Trolamine salicylate.Approved
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Diltiazem.Approved
TubocurarineDiltiazem may increase the neuromuscular blocking activities of Tubocurarine.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Diltiazem.Approved, Investigational, Nutraceutical
UdenafilUdenafil may increase the antihypertensive activities of Diltiazem.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Diltiazem.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Diltiazem.Approved
UnoprostoneDiltiazem may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilThe risk or severity of hypotension can be increased when Urapidil is combined with Diltiazem.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Diltiazem.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
ValinomycinThe serum concentration of Valinomycin can be increased when it is combined with Diltiazem.Experimental
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Diltiazem.Approved, Investigational
ValsartanValsartan may increase the hypotensive activities of Diltiazem.Approved, Investigational
ValspodarThe serum concentration of Valspodar can be increased when it is combined with Diltiazem.Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Diltiazem.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Diltiazem.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Diltiazem.Approved
VecuroniumDiltiazem may increase the neuromuscular blocking activities of Vecuronium.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Diltiazem.Approved, Investigational
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Diltiazem.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Diltiazem.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Diltiazem.Approved
VerapamilThe risk or severity of hypotension can be increased when Verapamil is combined with Diltiazem.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Diltiazem.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Diltiazem.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Diltiazem.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Diltiazem.Approved
VincamineDiltiazem may increase the hypotensive activities of Vincamine.Experimental
VincristineThe serum concentration of Vincristine can be increased when it is combined with Diltiazem.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Diltiazem.Approved, Investigational
VinflunineThe metabolism of Vinflunine can be decreased when combined with Diltiazem.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Diltiazem.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be decreased when combined with Diltiazem.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Diltiazem.Approved, Investigational
VoacamineThe serum concentration of Diltiazem can be increased when it is combined with Voacamine.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Diltiazem.Approved
VoriconazoleThe metabolism of Diltiazem can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Diltiazem.Approved, Investigational
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Diltiazem.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Diltiazem.Approved
WIN 55212-2The metabolism of WIN 55212-2 can be decreased when combined with Diltiazem.Experimental
XipamideDiltiazem may increase the hypotensive activities of Xipamide.Experimental
YohimbineYohimbine may decrease the antihypertensive activities of Diltiazem.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Diltiazem.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Diltiazem.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Diltiazem.Approved, Illicit, Investigational
ZaltoprofenThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Zaltoprofen.Approved, Investigational
ZiconotideThe metabolism of Ziconotide can be decreased when combined with Diltiazem.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Diltiazem.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
ZiprasidoneThe risk or severity of hypotension can be increased when Ziprasidone is combined with Diltiazem.Approved
ZofenoprilDiltiazem may increase the hypotensive activities of Zofenopril.Experimental
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Diltiazem.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Diltiazem.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Diltiazem.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Diltiazem.Approved
ZosuquidarThe serum concentration of Diltiazem can be increased when it is combined with Zosuquidar.Investigational
ZotepineThe metabolism of Zotepine can be decreased when combined with Diltiazem.Approved, Investigational, Withdrawn
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Diltiazem.Approved, Investigational
Food Interactions
  • Avoid natural licorice.
  • Take this medication 30 minutes before meals.

References

Synthesis Reference

Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.

US3562257
General References
Not Available
External Links
Human Metabolome Database
HMDB0014487
KEGG Drug
D07845
KEGG Compound
C06958
PubChem Compound
39186
PubChem Substance
46505667
ChemSpider
35850
BindingDB
50004704
ChEBI
101278
ChEMBL
CHEMBL23
Therapeutic Targets Database
DAP001262
PharmGKB
PA449334
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Diltiazem
ATC Codes
C05AE03 — DiltiazemC08DB01 — Diltiazem
AHFS Codes
  • 24:28.92 — Miscellaneous Calcium-channel Blocking Agents
MSDS
Download (73.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingPreventionInduction of intra-operative hypotension1
1CompletedNot AvailableDrug Dependence1
1CompletedNot AvailableNonvalvular Atrial Fibrillation1
1CompletedBasic ScienceDrug-induced QT Interval Prolongation / Pharmacodynamics / Pharmacokinetics1
1CompletedBasic ScienceHealthy Volunteers3
1CompletedBasic ScienceHealthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein1
1CompletedBasic ScienceThrombosis1
1CompletedOtherDrug-induced QT Interval Prolongation / Pharmacodynamics / Pharmacokinetics1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentAtherosclerosis1
1CompletedTreatmentCLARITHROMYCIN/DILTIAZEM [VA Drug Interaction]1
1CompletedTreatmentCardiovascular Disease (CVD) / High Blood Pressure (Hypertension) / Human Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentHealthy Volunteers2
1CompletedTreatmentHigh Blood Pressure (Hypertension)1
1CompletedTreatmentPharmacokinetics1
1TerminatedOtherHealthy Volunteers1
1TerminatedTreatmentFood Intake1
1Unknown StatusTreatmentAdult Subjects With Anal Fissures1
1Unknown StatusTreatmentDiltiazem Skin Sensitivity1
1Unknown StatusTreatmentSkin Irritation1
1WithdrawnTreatmentHepatitis C Viral Infection / High Blood Pressure (Hypertension)1
1, 2CompletedTreatmentCraniotomy / High Blood Pressure (Hypertension)1
1, 2CompletedTreatmentMetabolic Syndromes1
2CompletedTreatmentDigital Ulcer of Scleroderma1
2RecruitingTreatmentFlu caused by Influenza1
2, 3CompletedTreatmentHypertrophic Cardiomyopathy1
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
3CompletedTreatmentArrythmias / Cardiovascular Disease (CVD) / Heart Diseases / Nonvalvular Atrial Fibrillation1
3CompletedTreatmentCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedTreatmentChronic Anal Fissures2
3CompletedTreatmentHeart Failure, Unspecified / High Blood Pressure (Hypertension)1
3CompletedTreatmentNonvalvular Atrial Fibrillation1
3TerminatedTreatmentHeart Failure, Unspecified / Nonvalvular Atrial Fibrillation1
3Unknown StatusTreatmentIschaemia-reperfusion Injury1
3WithdrawnTreatmentDiabetic Nephropathies / High Blood Pressure (Hypertension)1
4CompletedSupportive CarePain1
4CompletedTreatmentAcute Myocardial Infarction (AMI) / Percutaneous Coronary Intervention1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentHeart Rate and Rhythm Disorders1
4CompletedTreatmentRapid Ventricular Response Atrial Fibrillation1
4RecruitingTreatmentAcute Ischemic Stroke (AIS)1
4RecruitingTreatmentAtrial Fibrillation and Flutter1
4RecruitingTreatmentAtrial Flutter / Nonvalvular Atrial Fibrillation1
4RecruitingTreatmentFissure in Ano1
4RecruitingTreatmentNonvalvular Atrial Fibrillation / Permanent Atrial Fibrillation1
4Unknown StatusTreatmentNonvalvular Atrial Fibrillation1
Not AvailableActive Not RecruitingTreatmentChronic Anal Fissures1
Not AvailableCompletedDiagnosticCoronary Artery Ectasia1
Not AvailableCompletedTreatmentArrythmias / Nonvalvular Atrial Fibrillation1
Not AvailableTerminatedTreatmentNon-Cardiac Chest Pain1
Not AvailableUnknown StatusTreatmentFamilial Primary Pulmonary Hypertension / Idiopathic Pulmonary Arterial Hypertension / Primary Pulmonary Hypertension / Pulmonary Arterial Hypertension (PAH)1

Pharmacoeconomics

Manufacturers
  • Biovail laboratories inc
  • Watson laboratories inc florida
  • Watson laboratories inc
  • Apotex inc
  • Actavis elizabeth llc
  • Kv pharmaceutical co
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Apotex inc etobicoke site
  • Biovail corp international
  • Biovail laboratories international srl
  • Apotex inc richmond hill
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • International medication systems ltd
  • Taylor pharmacal co
  • Teva parenteral medicines inc
  • Apothecon inc div bristol myers squibb
  • Dava pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Teva pharmaceuticals usa
  • Merck and co inc
Packagers
  • Abbott Laboratories Ltd.
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Akorn Inc.
  • Amerisource Health Services Corp.
  • Apotex Inc.
  • Apotheca Inc.
  • A-S Medication Solutions LLC
  • Atlantic Biologicals Corporation
  • Baxter International Inc.
  • Bedford Labs
  • Ben Venue Laboratories Inc.
  • Biovail Pharmaceuticals
  • Bracco Diagnostics Inc.
  • Bryant Ranch Prepack
  • BTA Pharmaceuticals
  • Cardinal Health
  • Caremark LLC
  • Comprehensive Consultant Services Inc.
  • Corepharma LLC
  • Dept Health Central Pharmacy
  • Direct Dispensing Inc.
  • DispenseXpress Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Driam Usa Inc.
  • Elan Pharmaceuticals Inc.
  • Ethex Corp.
  • Ethypharm
  • Forest Pharmaceuticals
  • Gruppo Lepetit SPA
  • Heartland Repack Services LLC
  • Hl Moore Drug Exchange
  • Hospira Inc.
  • Inwood Labs
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • KV Pharmaceutical Co.
  • Lake Erie Medical and Surgical Supply
  • Liberty Pharmaceuticals
  • Long Wing International Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medisca Inc.
  • Meridian Medical Technologies Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Neighborcare Repackaging Inc.
  • Neuman Distributors Inc.
  • Novex Pharma
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmacy Service Center
  • Pharmedium
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Prescript Pharmaceuticals
  • Rebel Distributors Corp.
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Sandhills Packaging Inc.
  • Sanofi-Aventis Inc.
  • Southwood Pharmaceuticals
  • Teva Pharmaceutical Industries Ltd.
  • Ther-Rx Corp.
  • Torpharm Inc.
  • Tya Pharmaceuticals
  • UDL Laboratories
  • Vangard Labs Inc.
  • Vetter Pharma Fertigung GmbH and Co. KG
  • Watson Pharmaceuticals
Dosage forms
FormRouteStrength
Capsule, extended releaseOral120 mg
Capsule, extended releaseOral180 mg
Capsule, extended releaseOral240 mg
Capsule, extended releaseOral300 mg
Tablet, coatedOral120 mg/1
Tablet, coatedOral30 mg/1
Tablet, coatedOral60 mg/1
Tablet, coatedOral90 mg/1
CapsuleOral240 mg/1
LiquidIntravenous5 mg
Capsule, extended releaseOral60 mg
Capsule, extended releaseOral90 mg
CapsuleOral120 mg/1
CapsuleOral300 mg/1
Injection, solutionIntravenous.83 mg/mL
Injection, solutionIntravenous1 mg/mL
Capsule, coated, extended releaseOral360 mg/1
CapsuleOral180 mg/1
Capsule, extended releaseOral60 mg/1
Capsule, extended releaseOral90 mg/1
InjectionIntravenous5 mg/mL
Injection, powder, lyophilized, for solutionIntravenous100 mg/1
Injection, solutionIntravenous5 mg/mL
TabletOral120 mg/1
TabletOral30 mg/1
TabletOral60 mg/1
TabletOral90 mg/1
Tablet, film coatedOral120 mg/1
Tablet, film coatedOral30 mg/1
Tablet, film coatedOral60 mg/1
Tablet, film coatedOral90 mg/1
Capsule, coated, extended releaseOral120 mg/1
Capsule, coated, extended releaseOral180 mg/1
Capsule, coated, extended releaseOral240 mg/1
Capsule, coated, extended releaseOral300 mg/1
CapsuleOral90 mg/1
SolutionIntravenous5 mg
Tablet, extended releaseOral120 mg/1
Tablet, extended releaseOral180 mg/1
Tablet, extended releaseOral240 mg/1
Tablet, extended releaseOral300 mg/1
Tablet, extended releaseOral360 mg/1
Tablet, extended releaseOral420 mg/1
TabletOral30 mg
TabletOral60 mg
Capsule, extended releaseOral360 mg
Capsule, extended releaseOral120 mg/1
Capsule, extended releaseOral180 mg/1
Capsule, extended releaseOral240 mg/1
Capsule, extended releaseOral300 mg/1
Capsule, extended releaseOral360 mg/1
Capsule, extended releaseOral420 mg/1
Tablet, extended releaseOral120 mg
Tablet, extended releaseOral180 mg
Tablet, extended releaseOral240 mg
Tablet, extended releaseOral300 mg
Tablet, extended releaseOral360 mg
Prices
Unit descriptionCostUnit
Cormax 0.05% Solution 50ml Bottle81.6USD bottle
Cormax 0.05% Solution 25ml Bottle45.99USD bottle
Cormax 0.05% Cream 15 gm Tube43.98USD tube
Diltiazem hcl 100 mg vial9.54USD vial
Diltiazem hcl powder8.42USD g
Cardizem CD 360 mg 24 Hour Capsule7.94USD capsule
Cardizem cd 360 mg capsule7.63USD capsule
Cardizem CD 300 mg 24 Hour Capsule7.3USD capsule
Cardizem LA 420 mg 24 Hour tablet5.56USD tablet
Cardizem CD 240 mg 24 Hour Capsule5.48USD capsule
Cardizem la 420 mg tablet5.35USD tablet
Diltiazem HCl Coated Beads 420 mg 24 Hour tablet5.01USD tablet
Cardizem la 360 mg tablet4.94USD tablet
Cardizem LA 360 mg 24 Hour tablet4.81USD tablet
Cardizem LA 300 mg 24 Hour tablet4.71USD tablet
Diltiazem HCl Coated Beads 360 mg 24 Hour tablet4.62USD tablet
Cardizem la 300 mg tablet4.59USD tablet
Diltiazem HCl Coated Beads 300 mg 24 Hour tablet4.3USD tablet
Cardizem CD 180 mg 24 Hour Capsule3.98USD capsule
Tiazac 420 mg 24 Hour Capsule3.88USD capsule
Tiazac 360 mg 24 Hour Capsule3.7USD capsule
Cardizem LA 240 mg 24 Hour tablet3.67USD tablet
Tiazac 300 mg 24 Hour Capsule3.64USD capsule
Cardizem la 240 mg tablet3.53USD tablet
Cardizem 120 mg tablet3.49USD tablet
Cardizem CD 120 mg 24 Hour Capsule3.4USD capsule
Dilacor XR 180 mg 24 Hour Capsule3.3USD capsule
Dilacor XR 240 mg 24 Hour Capsule3.3USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour tablet3.3USD tablet
Dilacor xr 240 mg capsule3.29USD capsule
Cardizem Cd 300 mg Controlled-Delivery Capsule3.25USD capsule
Cardizem la 180 mg tablet3.15USD tablet
Cardizem LA 180 mg 24 Hour tablet3.07USD tablet
Dilacor xr 180 mg capsule3.07USD capsule
Tiazac er 420 mg capsule3.03USD capsule
Cardizem la 120 mg tablet2.98USD tablet
Diltiazem HCl Coated Beads 180 mg 24 Hour tablet2.95USD tablet
Diltiazem HCl ER Beads 420 mg 24 Hour Capsule2.87USD capsule
Dilacor XR 120 mg 24 Hour Capsule2.86USD capsule
Tiazac er 360 mg capsule2.86USD capsule
Tiazac er 300 mg capsule2.83USD capsule
Tiazac 240 mg 24 Hour Capsule2.8USD capsule
Cartia XT 300 mg 24 Hour Capsule2.76USD capsule
Dilt-CD 300 mg 24 Hour Capsule2.76USD capsule
Diltiazem HCl Coated Beads 300 mg 24 Hour Capsule2.76USD capsule
Cormax 0.05% cream2.71USD g
Cartia xt 300 mg capsule2.66USD capsule
Dilt-cd er 300 mg capsule2.66USD capsule
Dilacor xr 120 mg capsule2.61USD capsule
Cardizem Cd 240 mg Controlled-Delivery Capsule2.6USD capsule
Diltiazem HCl ER Beads 360 mg 24 Hour Capsule2.44USD capsule
Tiazac 360 mg Extended-Release Capsule2.42USD capsule
Diltiazem HCl ER Beads 300 mg 24 Hour Capsule2.39USD capsule
Cardizem LA 120 mg 24 Hour tablet2.35USD tablet
Tiazac 240 mg capsule sa2.31USD capsule
Tiazac er 240 mg capsule2.18USD capsule
Cardizem cd 300 mg capsule2.15USD capsule
Cartia XT 240 mg 24 Hour Capsule2.13USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour Capsule2.13USD capsule
Dilt-cd 240 mg capsule2.05USD capsule
Cardizem 90 mg tablet2.02USD tablet
Tiazac 180 mg 24 Hour Capsule1.98USD capsule
Tiazac 300 mg Extended-Release Capsule1.98USD capsule
Cardizem Cd 180 mg Controlled-Delivery Capsule1.96USD capsule
Diltiazem HCl ER Beads 240 mg 24 Hour Capsule1.85USD capsule
Cardizem sr 120 mg capsule1.83USD capsule
Apo-Diltiaz Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Novo-Diltazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Ratio-Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Sandoz Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Cardizem cd 240 mg capsule1.69USD capsule
Tiazac 120 mg 24 Hour Capsule1.69USD capsule
Tiazac 240 mg Extended-Release Capsule1.61USD capsule
Tiazac er 180 mg capsule1.52USD capsule
Cartia XT 180 mg 24 Hour Capsule1.5USD capsule
Dilt-CD 180 mg 24 Hour Capsule1.5USD capsule
Diltiazem HCl Coated Beads 180 mg 24 Hour Capsule1.5USD capsule
Cardizem Cd 120 mg Controlled-Delivery Capsule1.48USD capsule
Apo-Diltiaz Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Novo-Diltazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Nu-Diltiaz-Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Ratio-Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Sandoz Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Tiazac Xc 240 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 300 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 360 mg Extended-Release Tablet1.46USD tablet
Dilt-cd 180 mg capsule1.45USD capsule
Diltiazem HCl 120 mg tablet1.42USD tablet
Diltiazem 120 mg tablet1.36USD tablet
Apo-Diltiaz Tz 360 mg Extended-Release Capsule1.36USD capsule
Novo-Diltiazem Hcl Er 360 mg Extended-Release Capsule1.36USD capsule
Sandoz Diltiazem T 360 mg Extended-Release Capsule1.36USD capsule
Cardizem 30 mg tablet1.34USD tablet
Diltiazem HCl ER Beads 180 mg 24 Hour Capsule1.3USD capsule
Diltiazem HCl CR 120 mg 12 Hour Capsule1.29USD capsule
Tiazac er 120 mg capsule1.26USD capsule
Cartia XT 120 mg 24 Hour Capsule1.25USD capsule
Dilt-CD 120 mg 24 Hour Capsule1.25USD capsule
Diltiazem HCl Coated Beads 120 mg 24 Hour Capsule1.25USD capsule
Cardizem cd 180 mg capsule1.24USD capsule
Tiazac 180 mg Extended-Release Capsule1.21USD capsule
Cartia xt 120 mg capsule1.2USD capsule
Dilt-cd 120 mg capsule1.2USD capsule
Diltiazem HCl CR 240 mg 24 Hour Capsule1.19USD capsule
Diltia XT 240 mg 24 Hour Capsule1.17USD capsule
Diltiazem HCl CR 180 mg 24 Hour Capsule1.11USD capsule
Apo-Diltiaz Tz 300 mg Extended-Release Capsule1.11USD capsule
Novo-Diltiazem Hcl Er 300 mg Extended-Release Capsule1.11USD capsule
Sandoz Diltiazem T 300 mg Extended-Release Capsule1.11USD capsule
Tiazac Xc 180 mg Extended-Release Tablet1.1USD tablet
Diltia XT 180 mg 24 Hour Capsule1.1USD capsule
Apo-Diltiaz Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Novo-Diltazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Nu-Diltiaz-Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Ratio-Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Sandoz Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Diltiazem HCl ER Beads 120 mg 24 Hour Capsule1.08USD capsule
Diltiazem HCl 90 mg tablet1.05USD tablet
Diltiazem 90 mg tablet1.01USD tablet
Diltiazem HCl CR 90 mg 12 Hour Capsule0.99USD capsule
Cardizem cd 120 mg capsule0.97USD capsule
Cardizem 60 mg tablet0.95USD tablet
Diltiazem HCl CR 120 mg 24 Hour Capsule0.95USD capsule
Apo-Diltiaz Tz 240 mg Extended-Release Capsule0.9USD capsule
Novo-Diltiazem Hcl Er 240 mg Extended-Release Capsule0.9USD capsule
Sandoz Diltiazem T 240 mg Extended-Release Capsule0.9USD capsule
Tiazac 120 mg Extended-Release Capsule0.89USD capsule
Diltiazem HCl CR 60 mg 12 Hour Capsule0.86USD capsule
Apo-Diltiaz Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Novo-Diltazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Nu-Diltiaz-Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Ratio-Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Sandoz Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Tiazac Xc 120 mg Extended-Release Tablet0.83USD tablet
Cartia xt 240 mg capsule0.81USD capsule
Diltiazem HCl 60 mg tablet0.77USD tablet
Diltiazem 60 mg tablet0.74USD tablet
Apo-Diltiaz Tz 180 mg Extended-Release Capsule0.68USD capsule
Novo-Diltiazem Hcl Er 180 mg Extended-Release Capsule0.68USD capsule
Sandoz Diltiazem T 180 mg Extended-Release Capsule0.68USD capsule
Cartia xt 180 mg capsule0.6USD capsule
Apo-Diltiaz Tz 120 mg Extended-Release Capsule0.5USD capsule
Novo-Diltiazem Hcl Er 120 mg Extended-Release Capsule0.5USD capsule
Sandoz Diltiazem T 120 mg Extended-Release Capsule0.5USD capsule
Diltiazem HCl 30 mg tablet0.49USD tablet
Diltiazem 30 mg tablet0.47USD tablet
Diltia xt 240 mg capsule0.43USD capsule
Diltia xt 180 mg capsule0.42USD capsule
Diltiazem-d5w 250 mg/250 ml0.42USD ml
Diltia xt 120 mg capsule0.38USD capsule
Apo-Diltiaz 60 mg Tablet0.38USD tablet
Novo-Diltazem 60 mg Tablet0.38USD tablet
Nu-Diltiaz 60 mg Tablet0.38USD tablet
Apo-Diltiaz 30 mg Tablet0.22USD tablet
Novo-Diltazem 30 mg Tablet0.22USD tablet
Nu-Diltiaz 30 mg Tablet0.22USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5286497No1994-05-202011-05-20Us
CA2307547No2007-08-142020-05-04Canada
CA2111085No1999-04-272012-06-25Canada
US7108866No1999-12-172019-12-17Us
US6923984No2001-02-252021-02-25Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)187-188Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.
water solubility465 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP2.8Not Available
Caco2 permeability-4.38ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0168 mg/mLALOGPS
logP3.09ALOGPS
logP2.73ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.86ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.08 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity114.37 m3·mol-1ChemAxon
Polarizability43.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9788
Blood Brain Barrier+0.506
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8645
P-glycoprotein inhibitor IInhibitor0.8675
P-glycoprotein inhibitor IIInhibitor0.8997
Renal organic cation transporterNon-inhibitor0.7634
CYP450 2C9 substrateNon-substrate0.699
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8681
Ames testNon AMES toxic0.6985
CarcinogenicityNon-carcinogens0.8772
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.4130 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Inhibitor0.7723
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0ab9-9200000000-b1095b8fe5973d23fdd6
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzothiazepines. These are organic compounds containing a benzene fused to a thiazepine ring (a seven-membered ring with a nitrogen atom and a sulfur atom replacing two carbon atoms).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazepines
Sub Class
Not Available
Direct Parent
Benzothiazepines
Alternative Parents
Phenoxy compounds / Methoxybenzenes / Anisoles / Alkyl aryl ethers / Alkylarylthioethers / Tertiary carboxylic acid amides / Trialkylamines / Amino acids and derivatives / Lactams / Carboxylic acid esters
show 6 more
Substituents
Benzothiazepine / Phenoxy compound / Aryl thioether / Anisole / Phenol ether / Methoxybenzene / Alkyl aryl ether / Alkylarylthioether / Monocyclic benzene moiety / Benzenoid
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (CHEBI:101278)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only...
Gene Name
CACNG1
Uniprot ID
Q06432
Uniprot Name
Voltage-dependent calcium channel gamma-1 subunit
Molecular Weight
25028.105 Da
References
  1. Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A: Ligands of diltiazem binding site: an overview of some chemotypes. Mini Rev Med Chem. 2009 Oct;9(12):1379-88. [PubMed:19929811]
  2. Romero M, Sanchez I, Pujol MD: New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships. Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):113-41. [PubMed:15320693]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. [PubMed:12124305]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  4. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  3. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  2. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K: Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. [PubMed:11560871]
  2. McGinnity DF, Parker AJ, Soars M, Riley RJ: Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos. 2000 Nov;28(11):1327-34. [PubMed:11038161]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674]
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. [PubMed:12128170]
  3. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett. 1993 Jun 7;324(1):99-102. [PubMed:8099333]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:39