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Identification
NameCalcium
Accession NumberDB01373
TypeSmall Molecule
GroupsNutraceutical
DescriptionCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alka-cal TabletsTablet166.6 mgOralMorter HealthsystemNot applicableNot applicableCanada
Leucovorin Ca Inj (pharm. Bulk Vial) 10mg/mlLiquid10 mgIntravenousDavid Bull Laboratories (Pty) Ltd.1992-12-311997-08-14Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bakanasan Calcium Citrate PowderPowder63.4 mgOralRheingold Food International Ltd.1995-12-311999-08-03Canada
Biocalth Calcium PowderPowder336 mgOralBiocalth International Corporation2003-05-102006-07-31Canada
Biocalth Calcium SupplementTablet100 mgOralBiocalth International Corporation2002-10-152006-07-31Canada
Bodysmarts With CalciumTablet30 mgOralCadbury Adams Canada Inc.2001-02-192005-07-28Canada
Cal 500 Tab 500mgTablet500 mgOralBioforce Canada Inc.1985-12-311997-04-04Canada
Cal Gel Cap 45mgCapsule45 mgOralLaboratoire Lalco Inc.1977-12-311997-07-31Canada
Cal Supp 500Tablet500 mgOralWn Pharmaceuticals Ltd.2002-06-062006-08-08Canada
Cal Supp 500 - TabTablet500 mgOralVita Health Products Inc1996-10-112008-08-05Canada
Cal-citrusTablet200 mgOralSterimax Inc1996-09-102006-10-20Canada
CalciumCapsule150 mgOralSeroyal International Inc.1996-12-312009-07-06Canada
CalciumTablet500 mgOralHealth Wise Nutrition Inc.2000-04-042002-07-18Canada
Calcium 350 Mg (calcium Citrate) - CapletTablet350 mgOralVita Health Products Inc1996-10-112007-07-30Canada
Calcium 350 Mg (calcium Citrate) CapletTablet350 mgOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012008-07-07Canada
Calcium 350mgTablet350 mgOralGeneral Nutrition Canada Inc.2001-10-202009-08-05Canada
Calcium 500 mgTablet500 mgOralNutricorp International2001-11-012007-08-01Canada
Calcium 600Tablet600 mgOralLaboratoire Riva Inc2001-01-152008-08-11Canada
Calcium 600mg Dietary SupplementTablet600 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Calcium 650mgTablet650 mgOralNutricorp International1999-12-152007-08-01Canada
Calcium 650mg TabTablet650 mgOralJamieson Laboratories Ltd1994-12-312006-07-25Canada
Calcium Caps 400mgCapsule400 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium CarbonateTablet500 mgOralVita Health Products Inc1985-12-312004-07-26Canada
Calcium Carbonate 1500mgTablet600 mgOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Calcium Carbonate TabTablet246 mgOralSwiss Herbal Remedies Ltd.1989-12-311998-07-15Canada
Calcium CitramateCapsule160.0 mgOralThorne Research Inc.1997-04-182006-08-04Canada
Calcium CitrateTablet200 mgOralVita Health Products Inc1998-01-132004-07-26Canada
Calcium CitrateTablet350 mgOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Calcium Citrate 300mgTablet300 mgOralWn Pharmaceuticals Ltd.1998-06-192008-07-17Canada
Calcium Gluconate Tablets USP 650 mgTablet60 mgOralPharmetics (2011) Inc2002-03-102006-07-27Canada
Calcium Lactate 650mgTablet120 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Calcium Lactate CapsCapsule100 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium Lactate Tab 84.5mgTablet84.5 mgOralLaboratoire Lalco Inc.1980-12-311997-07-31Canada
Calcium Lactate Tablets USP 650 mgTablet84 mgOralPharmetics (2011) Inc2002-03-102006-07-27Canada
Calcium LiquidLiquid100 mgOralPharmetics (2011) Inc2002-09-302009-07-30Canada
Calcium Liquid SyrupSyrup100 mgOralSupplements Aromatik Inc.2003-07-022008-08-01Canada
Calcium Sandoz Syr 110mg/5mlSyrup110 mgOralNovartis Consumer Health Canada Inc.1995-12-311999-07-21Canada
Calcium Syrup 110mg/5mlSyrup110 mgOralVita Health Products Inc1990-12-312002-07-31Canada
Calsan Chewable Tab 500mgTablet500 mgOralNovartis Consumer Health Canada Inc.1986-01-012008-07-15Canada
Chelated Calcium Supplement - 150mg TabTablet150 mgOralAlbion Laboratories Inc.1996-09-062002-07-12Canada
Chelazome Calcium 125mgTablet125 mgOralTrophic Canada Ltd.1987-12-312000-08-03Canada
Children's Chewable Calcium (chewable Tablets)Tablet266.7 mgOralGeneral Nutrition Canada Inc.1998-11-232007-08-01Canada
Coral CalciumPowder216.7 mgOralNature's Sunshine Products Of Canada Ltd.2003-12-012007-07-30Canada
Dia Cal Cap 500mgCapsule500 mgOralR & D Laboratories Inc.1991-12-312003-07-16Canada
Extra Strength Calcium Antacid ChewableTablet300 mgOralPerrigo International1996-12-311998-08-12Canada
Gellucal Cap 45mgCapsule45 mgOralVitalab1990-12-311996-09-09Canada
Hi Potency Cal Tab 650mgTablet650 mgOralSwiss Herbal Remedies Ltd.1986-12-311997-07-28Canada
Lactate De Calcium 648 mgTablet84.2 mgOralGamme Nature1990-12-312008-07-31Canada
Lactate De Calcium Tab 42.1mgTablet42.1 mgOralLe Naturiste J.M.B. Inc.1980-12-311997-07-23Canada
Mor-cal Tab 500mgTablet500 mgOralPharmetics (2011) Inc1986-12-312006-07-27Canada
Nutrol-cal Tab 875mgTablet350 mgOralRolmex International Inc.1990-12-311997-08-08Canada
Os-cal 250 mgTablet250 mgOralWyeth Canada1994-12-312003-07-28Canada
Os-cal 500Tablet500 mgOralWyeth Canada1993-12-312008-12-16Canada
Os-cal 500 Chewable Tab 500mgTablet500 mgOralWyeth Ayerst Canada Inc.1996-09-301998-01-28Canada
Os-cal 500 Chewable Tab 500mgTablet500 mgOralAyerst Laboratories1986-12-311997-08-15Canada
Pharmacal 500 Tab 500mgTablet500 mgOralPharmadex Laboratories Inc.1993-12-311999-08-28Canada
Prevencal Tab 500mgTablet500 mgOralLaboratoire Lalco Inc.1988-12-311997-07-31Canada
Regular Strength Calcium Antacid Chew. TabsTablet200 mgOralPerrigo International1996-12-311998-08-12Canada
Soluble Calcium Citrate 1200mgTablet250 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tropicana Calcium Supplement 344 mgSolution1.458 mgOralTropicana Canada2002-01-142007-06-21Canada
Tropicana Calcium Supplement 393 mgSolution1.667 mgOralTropicana Canada2002-02-182007-06-21Canada
Tropicana Calcium Supplement 604 mgSolution1.458 mgOralTropicana Canada2003-02-072007-06-21Canada
Tums 500 TabTablet500 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311996-09-12Canada
Tums Extra Strength Assorted Tropical FruitTablet300 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-09-101998-08-25Canada
Tums Ultra Strength Assorted Mint FlavoursTablet400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-12-311998-08-25Canada
Tums Ultra Strength Assorted Tropical FruitTablet400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-07-311998-08-25Canada
Tums Ultra Strength LiquidLiquid400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-04-172001-07-31Canada
Vitamine C Cap 600mgCapsule600 mgOralSisu Inc.1989-12-312008-07-25Canada
Webber Calcium Tab 500mgTablet500 mgOralNovartis Consumer Health Canada Inc.1985-12-311998-07-08Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7030 Calcium GoldCapsule.99 1/1OralApexel Co., Ltd2013-03-10Not applicableUs
7030 Calcium PremiumCapsule.99 1/1OralApexel Co., Ltd2013-03-10Not applicableUs
Ena Actimineral ALiquid803.8 mg/1000mLOralJinju Bio Food2013-06-28Not applicableUs
Hantai 8030 Ca-D3 GoldTablet.99 1/1OralApexel Co., Ltd.2015-05-18Not applicableUs
Hantai 8030 Ca-D3 PremiumTablet.99 1/1OralApexel Co., Ltd.2015-05-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
A D Calcium TabStar Products Inc.
A-D Calcium CapVitalab
A.R.T.H. Away FormulaAbundance Marketing Ltd.
Act EtidrocalActavis Pharma Company
Acti-cal/mag 2:1 + Zinc and D CapletActi Form Ltd.
Acti-megascorb Crystals PwrActi Form Ltd.
Actical Plus Calcium-magnesium-vitamin D3-silicon ChewableUsana Health Sciences Inc.
Active Calcium Plus Magnesium, Vitamin D and SiliconUsana Health Sciences Inc.
Actonel Plus CalciumWarner Chilcott Canada Co
Actonel Sachet KitWarner Chilcott Canada Co
Ad & Calcium CapLaboratoire Lalco Inc.
Ad Calcium CapLes Produits Gerbex Inc.
Alsimine W Vitamins A DAlsi Cie Ltee
Astral C TabAlbi Naturals
Avon Nutrivance Soft Calcium Chews With Vitamin DAvon Canada Ulc
B & J Formula Dietary SupplementGarden State Nutritionals
B-nexaUpsher Smith Laboratories, Inc.
BaisixProdemdis Enr.
BseltzerAbundance Marketing Ltd.
Buffered Vitamin C Powder With Ca Mg and KThorne Research Canada Ltd.
Buffered Vitamin C Pwr W Cal-mag-potassiumSisu Inc.
C-crystals With CalciumAlive Vitamins
C.H.V. FormulaNihon Kenko Zoushin Kenkyukai Canada Inc., Subsidery Of Nikken Usa Inc.
Cal & Mag Hvp Chel Plus C Potass & Zinc TabGahler Enterprises Ltd.
Cal M TabAnabolic Laboratories Inc.
Cal Mag Drink With Vitamin CWampole Brands
Cal Mag Plus - TabNutrilite, A Division Of Access Business Group, Llc
Cal Mag TabSwiss Herbal Remedies Ltd.
Cal-mag (one To One) With Potass & ZincGahler Enterprises Ltd.
Cal-mag Citrate Zinc & Vitamin D TabletsSwiss Herbal Remedies Ltd.
Cal-mag Complete With Zinc, C and DQuest Vitamins A Div Of Purity Life Health Products
Cal-mag Plus K, Mn and Zn CapletsHealth Wise Nutrition Inc.
Cal-mag TabletStandard Process Inc.
Cal-mag Vitamin C and Zinc TabSwiss Herbal Remedies Ltd.
Cal-mag With Vitamin DAlbi Imports Ltd.
Cal-mag With Zinc & Vitamin DHealth Wise Nutrition Inc.
Cal/mag 1:1 With Zinc and Vitamin D - TabletHealth Wise Nutrition Inc.
Cal/mag 2:1 With DWn Pharmaceuticals Ltd.
Cal/mag+dSeroyal International Inc.
Calburst Calcium 500mg With Vitamin DPharmavite Llc
Calci-yum Plus Magnesium + D3Nu Life Nutrition Ltd.
Calcimag TabLes Produits Naturels Suisse Inc.
CalcitolFrega Inc.
Calcium Mg and Zn Capsules With Vitamin DRheingold Food International Ltd.
Calcium & Magnesium Citrate Plus D With Manganese, Potassium & ZincNatural Factors Nutritional Products Ltd.
Calcium & Magnesium Plus Potassium & ZincNatural Factors Nutritional Products Ltd.
Calcium & Magnesium Plus Potassium, Zinc, & ManganeseNatural Factors Nutritional Products Ltd.
Calcium & Magnesium TabBioforce Canada Inc.
Calcium & Magnesium TabletsVita Health Products Inc
Calcium & Magnesium With Potassium & ZincWn Pharmaceuticals Ltd.
Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin DWn Pharmaceuticals Ltd.
Calcium & Magnesium With Vitamin DOrganika Health Products Inc.
Calcium & Vitamin DQuantofill Inc.
Calcium 250 Mg With Vitamin DGfr Pharma Ltd.
Calcium 400 With Magnesium - PwrHillestad Pharmaceuticals Usa
Calcium 500 With Vitamin D TabVita Health Products Inc
Calcium 500mg With Vitamin DNutricorp International
Calcium 600 + DLaboratoire Riva Inc
Calcium 600 + D ComprimesNobel Pharm Enr.
Calcium 600mg + Vit D3 125unit TabPharmetics (2011) Inc
Calcium 650mg With Vitamin DNutricorp International
Calcium A DProduits Phyto Inc.
Calcium and Mag-potass and Zinc CapGahler Enterprises Ltd.
Calcium and Magnesium 1:1 Plus TabletsAlbi Naturals
Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iuWn Pharmaceuticals Ltd.
Calcium and Magnesium Citrate With Vitamin DSisu Inc.
Calcium and Magnesium TabAlbi Imports Ltd.
Calcium and Magnesium TabletsVitazan Herbs & Vitamins Inc.
Calcium and Magnesium W Zinc TabPharmavite Llc
Calcium and Magnesium With Vitamin DVita Health Products Inc
Calcium and Magnesium With ZincVita Health Products Inc
Calcium and Vitamin D - Soft ChewVita Health Products Inc
Calcium Ascorbate 1000 Mg - TabletHealth Wise Nutrition Inc.
Calcium Ascorbate Cap 850mgQuest Vitamins A Div Of Purity Life Health Products
Calcium Ascorbate PowderEster C Health Co, Division Of Inter Cal Corp
Calcium Ascorbate Tab 550mgEster C Health Co, Division Of Inter Cal Corp
Calcium Caps Plus MagnesiumTwin Laboratories Inc.
Calcium Capsules With Magnesium and Vitamin DHerba Lab Inc.
Calcium Carbonate + Vitamin DWn Pharmaceuticals Ltd.
Calcium Carbonate Tablets With Vitamin DVita Health Products Inc
Calcium Chelate Plus Vit DHall Laboratories, Ltd.
Calcium Citrate and Vitamin D 200mg/160iuWn Pharmaceuticals Ltd.
Calcium Citrate With Vitamin DWn Pharmaceuticals Ltd.
Calcium Complex High GradeNew Spirit Naturals, Inc.
Calcium Et Magnesium Plus Vitamin DLaboratoire Lalco Inc.
Calcium Et Magnesium Plus Vitamine D/fe/znLaboratoire Lalco Inc.
Calcium Et Magnesium TabLaboratoire Lalco Inc.
Calcium Lactate PowderStandard Process Inc.
Calcium Magnesium 1000/500 - TabPro Shop Inc.
Calcium Magnesium 2:1 Tablets With Vitamin DSisu Inc.
Calcium Magnesium Avec Vitamine CLes Aliments Nutri Source Inc.
Calcium Magnesium Avec Vitamine D Et ZincLes Aliments Nutri Source Inc.
Calcium Magnesium Sulfur Silicon - TabPro Shop Inc.
Calcium Magnesium TabNutricorp International
Calcium Magnesium Tablets Nu LifeNu Life Nutrition Ltd.
Calcium Magnesium With Potassium TabNutrition For Life International
Calcium PlusLaboratoire Riva Inc
Calcium Tab W Vit DShoppers Drug Mart Inc.
Calcium With Magnesium and Vitamin DGeneral Nutrition Canada Inc.
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DJamieson Laboratories Ltd
Calcium With Vitamin D 200 Mg/160 IuWn Pharmaceuticals Ltd.
Calcium With Vitamin D2Sisu Inc.
Calcium With Vitamins C and D TabPure Life International Prods Inc.
Calcium-magnesium Cap 1:1 W Vitamin DSisu Inc.
Calcium-magnesium With K & Zn and Vitamin D3Holista Health (Canada) Inc.
Calcium, Magnesium, Zinc and DNutravite Pharmaceuticals Inc.
Calcium/magnesium DrinkNew Vision Nutritionals Company
Calcium/magnesium Supplement TabletsGeneral Nutrition Canada Inc.
Calcium/magnesium/vitamin D - CapsuleHolista Health (Canada) Inc.
CalcorSimone Protective Pharmaceuticals, Inc.
Calma-DWn Pharmaceuticals Ltd.
CalmaxMedia Power, Inc.
CalplusLifestyles Canada Corporation
Caltrate 600 Plus D - TabletWhitehall Robins Inc.
Cell-wiseMelaleuca Of Canada Inc.
Cell-wise Natural SourceMelaleuca Of Canada Inc.
Chela Calmag-100 Plus Zinc D3Nu Life Nutrition Ltd.
Chela Calmag-300 Plus Zinc D3Nu Life Nutrition Ltd.
Chelated Cal-mag(2:1)with Zn Vit.c and DHealth Wise Nutrition Inc.
Chelated Cal/mag/zn With VitaminsHealth Wise Nutrition Inc.
Chelated Calcium and Magnesium TabAlive Vitamins
Chewable Cal-mag Chocolate FlavourViva Life Science, Inc.
Chewable Calcium & Magnesium 2:1 TabletSwiss Herbal Remedies Ltd.
Chewable Calcium 500 Mg With Vitamin D 200 IuVita Health Products Inc
Chewable Calcium Plus Magnesium and MineralsNature's Sunshine Products Of Canada Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Chromium Gtf + CalciumWeider Nutrition Group (Canada) Ltd.
Citrate De Calcium Plus Vitamine D Et ZincSantÉ Naturelle (Ag) LtÉe
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc
Coral Calcium Plus Vitamin DHolista Health (Canada) Inc.
Coral Calcium Plus Vitamin D 210mg/100iuWn Pharmaceuticals Ltd.
Derma-forcePrairie Naturals
DidrocalWarner Chilcott Canada Co
Dol Mite TabSwiss Herbal Remedies Ltd.
Dolomite 1280mgRay Irastorza
Eden With Calcium and Vitamin DWarner Lambert Canada Inc.
Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mgNaturale Science Inc.
Effervescent Vitamin C Powder With Ca and mgThorne Research Canada Ltd.
Enviroflex - TabEnviro Tech International Canada
Ester C 500 TabNu Life Nutrition Ltd.
Ester C Calcium Ascorbate CapNatrol, Inc.
Ester C CapsuleNatural Factors Nutritional Products Ltd.
Ester C PowderNatural Factors Nutritional Products Ltd.
Ester C Tab ChewableNatrol, Inc.
Ester C Vitamin C and Calcium PwsNatrol, Inc.
Ester-CNatural Factors Nutritional Products Ltd.
Ester-C 500 mgWn Pharmaceuticals Ltd.
Ester-C 600 mgWn Pharmaceuticals Ltd.
Ester-C 787mgNatural Factors Nutritional Products Ltd.
Ester-C Calcium Ascor TabNatrol, Inc.
Ester-C Calcium Ascorbate CapsulesSwiss Herbal Remedies Ltd.
Ester-C Calcium Ascorbate TabNatrol, Inc.
Ester-C Calcium Ascorbate TabletsSwiss Herbal Remedies Ltd.
Ester-C PowderNatural Factors Nutritional Products Ltd.
Ester-C TabletNatural Factors Nutritional Products Ltd.
Ester-C Vitamin C With CalciumDarwen Holdings Ltd.
EtidrocalSanis Health Inc
Fb FormulaWeider Nutrition Group (Canada) Ltd.
FemidausePns Pharma Therapy
Feminex 300 TabSantÉ Naturelle (Ag) LtÉe
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Ferrous SulfateMartin Ekwealor Pharmaceuticals, Inc.
Flex CapsulesFoodscience Laboratories, Division Of Foodscience Corporation
Folcaps Omega-3Midlothian Laboratories
Formula 2025 TabStandard Process Inc.
Formula 9 TabPure Life International Prods Inc.
Formula A.R.-th Dietary SupplementRx Vitamins Inc.
Formula InfBalance Plus, Inc.
Formula IntBalance Plus, Inc.
Formula O-care Vitamin and Mineral SupplementFor Mor International Inc.
Formula OsgSeroyal International Inc.
Fusion Activator Formula TabL & S Research Corporation
Fusion PM Formula TabL & S Research Corporation
G.A.S. ComplexAbundance Marketing Ltd.
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Good Night/pm Formula TabNikken Usa, Incorporated
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hormodausse Plus Calc Et D TabLaboratoires Charton Laboratories
Hvp Chelated Cal/mag With Zinc and Vitamins C and DDarwen Holdings Ltd.
Hypo Vites TabPharmetics (2011) Inc
IpricalPep Products Inc.
Isotonix Calcium Plus FormulaMarket America, Inc.
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Liqui Cal-DTwin Laboratories Inc.
LiquicalLand Art Inc.
Liquid Cal-magSeroyal International Inc.
Liquid Cal/mag Plus DGahler Enterprises Ltd.
Liquid Calcium and Magnesium With Vit.dRheingold Food International Ltd.
Liquid Calcium With Vitamin DT & T Nutrition Inc.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
Mag/cal 1:1 Capsules W Vitamin DRheingold Food International Ltd.
MagnacalHolista Health (Canada) Inc.
Menocal TabLes Aliments Nutri Source Inc.
Mid-life Magnacal 2Holista Health (Canada) Inc.
Min-tran TabStandard Process Inc.
Mnps Formula SupplementGarden State Nutritionals
Mor-vites TabPharmetics (2011) Inc
Multi RolRolmex International Inc.
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi-min Electro C Pow Plus B2Quest Vitamins A Div Of Purity Life Health Products
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
Multimineral ChelatesW.R. Enterprises Inc.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamins and Minerals TabRandle Labs Inc.
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Mylan-eti-cal CarepacMylan Pharmaceuticals Ulc
Nata KompleteWh Nutritionals, Llc
NataviteSchein Pharmaceutical Canada Inc.
Natelle OneMEDA Pharmaceuticals
Nexa PlusUpsher Smith Laboratories, Inc.
Nexa Select Rx Prenatal Vitamin With Plant-based DHAUpsher Smith Laboratories, Inc.
Novo-etidronatecalTeva Canada Limited
Ntp-etidronate CalciumTeva Canada Limited
Nutravite Calcium Magnesium and Zinc CapsNutravite Pharmaceuticals Inc.
Nutri-chem Cal MagNutri Chem Pharmacy Ltd
Nutri-chem Calcium Magnesium With D and ZincNutri Chem Pharmacy Ltd
Nutrifer Plus TabletsWyeth Ayerst Canada Inc.
Nutrilite Double XNutrilite, A Division Of Access Business Group, Llc
O Calcium 500mg Plus D TabVita Health Products Inc
O-cal Prenatal VitaminPharmics, Inc.
O-calcium 250mg Plus DVita Health Products Inc
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day Bone BuilderBayer Inc Consumer Care
One A Day TabCountry Health Laboratories Ltd.
Opti-cal Chewable +d CapletNu Life Nutrition Ltd.
Orange Flavored Crystal Chews TabJeunique International Inc.
Orifer FSanofi Aventis Canada Inc
Os-cal-D 500Wyeth Canada
Osteo FormulaNutramed Laboratories Inc.
Osteo Formula TabQuest Vitamins A Div Of Purity Life Health Products
Osteo TabletsQuest Vitamins A Div Of Purity Life Health Products
Osteo-lifeViva Pharmaceutical Inc.
Osteo-plusRolmex International Inc.
Osteocit-DSeaford Pharmaceuticals Inc
OsteoligoClinique Lafontaine Inc, Division Les Importations Ortho
Oyster Shell Calcium With Vitamin DCardinal Health
Phytofortis + Calcium A-DProduits Phyto Inc.
PMS-risedronate Plus CalciumPharmascience Inc
Pnv-dhaAcella Pharmaceuticals, LLC
Port A Mins Super Cal-mag 300/150 With Vitamin D3Great Earth Companies, Inc.
Port A Mins Super Cal-mag 600/300Great Earth Companies, Inc.
Port A Mins Super Calcium 375 With Vitamin D3Great Earth Companies, Inc.
Port A Mins Super Calcium 750 With Vitamin D3Great Earth Companies, Inc.
Pour Ma SantéProdemdis Enr.
PregvitDuchesnay Inc
Pregvit Folic 4Duchesnay Inc
Pregvit Folic 5Duchesnay Inc
PremelLe Naturiste J.M.B. Inc.
Prenatal Vitamins Plusbryant ranch prepack
Prenavite Forte TabletsRoberts Pharmaceutical Canada Inc.
Prenavite TabletsRoberts Pharmaceutical Canada Inc.
Prevencal + D A Croquer 600mgLaboratoire Lalco Inc.
Prevencal 300 + D A CroquerLaboratoire Lalco Inc.
Prevencal 500 +dLaboratoire Lalco Inc.
Prevencal 600 + D Et FerLaboratoire Lalco Inc.
Prevencal 600 + D Et MagnesiumLaboratoire Lalco Inc.
Pure Calcium CalciumSaimdang Cosmetics Co., Ltd
Redoxon-calBayer Inc Consumer Care
ReebokClearly Canadian Beverage Corporation
Revitex Ampoules Et ComprimesLes Produits Gerbex Inc.
Revival 1 TabBio Vita
Rolaids Extra Strength Multi-symptom TabletsSanofi Consumer Health Inc Sanofi Sante Grand Public Inc
Rolaids Extra Strength TabWarner Lambert Canada Inc.
Silica-calcium With Biotin CapsulesNaka Sales Ltd.
Somarexin and C 1000Laboratoire Lalco Inc.
Spectrum 2 CapNf Formulas Inc.
Super C Crystals W CalciumNu Life Nutrition Ltd.
Super C-M-KCreative Nutrition Canada Corp.
Super Cal Mag PlusShaklee Canada Inc
Super Charged EnergySimone Protective Pharmaceuticals, Inc.
Super Daily No 2W.R. Enterprises Inc.
Supplement De Vitamines Et MinerauxLand Art Inc.
Supplements De Vitamines Et MinerauxLand Art Inc.
Swical D-M - TabLes Laboratoires Swisse Inc.
Swical-multiLes Laboratoires Swisse Inc.
T-PA CapSeroyal International Inc.
Tianshi Calcium and Vitamin D Chewable Tablets (melon Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium and Vitamin D Chewable Tablets (peach Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium and Vitamin D Chewable Tablets (strawberry Flavour)Tianjin Tianshi Group Co., Ltd.
Tianshi Calcium With Natural Source Vitamin D TabletsTianjin Tianshi Group Co., Ltd.
Tianshi Calcium With Natural Source Vitamin E Softgel CapsulesTianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder ITianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder IITianjin Tianshi Group Co., Ltd.
Tianshi Vital Powder IIITianjin Tianshi Group Co., Ltd.
Timed Release and Esterified Vitamin C-500Great Earth Companies, Inc.
Timed Release Ester-C 1000mgSwiss Herbal Remedies Ltd.
Tri-mins - CapAlbion Laboratories Inc.
Tropicana Calcium & Vitamin C SupplementTropicana Canada
Tropicana Calcium and Vitamin C SupplementTropicana Canada
Tums Ultra Strength Liquid Plus Anti-gasSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ultimatecare One NfTrigen Laboratories, Inc.
Usana Calmag Plus Tablets - TabUsana Health Sciences Inc.
Usana Multimineral TabletsUsana Health Sciences Inc.
Usana Multimineral Tablets - TabUsana Health Sciences Inc.
Usana Optimizer Actical Plus Calcium-magnesium-vitamin D3-silicon TabletsUsana Health Sciences Inc.
Viamon Ampoules Et ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Vimeral TabIcn Canada Ltd.
Vit C W Calc-mag and Potass PowderNf Formulas Inc.
Vita - Gl CapsulesAnton Hubner Gmbh & Co.
Vitaflex Dietary SuplementHome Shopping Network Direct
Vitafol CapletEverett Laboratories, Inc.
Vitafol Ob CapletEverett Laboratories, Inc.
Vitalife - CapsuleHolista Health (Canada) Inc.
Vitality Brand Calcium Plus TabGolden Neo Life Diamite International, Limited
Vitamin C and Calcium TabNatrol, Inc.
Vitamin C Calcium PwrSisu Inc.
Vitamin D + Calcium Dietary SupplementGarden State Nutritionals
Vitamines A - D CalciumLaboratoire Lalco Inc.
Women's FormulaPro Ma Systems
Women's Support TabletsGeneral Nutrition Canada Inc.
ZingiberPru Gen, Inc. Pharmaceuticals
Salts
Name/CASStructureProperties
Calcium acetate
ThumbNot applicableDBSALT001052
Categories
UNIISY7Q814VUP
CAS number7440-70-2
WeightAverage: 40.078
Monoisotopic: 39.962591155
Chemical FormulaCa
InChI KeyOYPRJOBELJOOCE-UHFFFAOYSA-N
InChI
InChI=1S/Ca
IUPAC Name
calcium
SMILES
[Ca]
Pharmacology
IndicationCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
Structured Indications Not Available
PharmacodynamicsCalcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.
Mechanism of actionCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
TargetKindPharmacological actionActionsOrganismUniProt ID
Voltage-dependent L-type calcium channel subunit alpha-1CProteinyes
ligand
HumanQ13936 details
Calcium-transporting ATPase type 2C member 1Proteinyes
agonist
HumanP98194 details
Troponin C, skeletal muscleProteinyes
agonist
HumanP02585 details
Troponin C, slow skeletal and cardiac musclesProteinyes
agonist
HumanP63316 details
Spectrin beta chain, non-erythrocytic 1Proteinunknown
agonist
HumanQ01082 details
Protein S100-BProteinunknownNot AvailableHumanP04271 details
CalpastatinProteinunknownNot AvailableHumanP20810 details
Cartilage oligomeric matrix proteinProteinunknownNot AvailableHumanP49747 details
CalmodulinProteinunknownNot AvailableHumanP62158 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationThe kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Beta-Alanine MetabolismMetabolicSMP00007
Phospholipid BiosynthesisMetabolicSMP00025
Pantothenate and CoA BiosynthesisMetabolicSMP00027
Riboflavin MetabolismMetabolicSMP00070
Arachidonic Acid MetabolismMetabolicSMP00075
Meloxicam Action PathwayDrug actionSMP00106
Mefenamic Acid Action PathwayDrug actionSMP00109
Malate-Aspartate ShuttleMetabolicSMP00129
Dicumarol Action PathwayDrug actionSMP00270
Ardeparin Action PathwayDrug actionSMP00275
Streptokinase Action PathwayDrug actionSMP00282
Acebutolol Action PathwayDrug actionSMP00296
Atenolol Action PathwayDrug actionSMP00298
Nadolol Action PathwayDrug actionSMP00303
Oxprenolol Action PathwayDrug actionSMP00304
Pindolol Action PathwayDrug actionSMP00306
Gaucher DiseaseDiseaseSMP00349
17-Beta Hydroxysteroid Dehydrogenase III DeficiencyDiseaseSMP00356
Fc Epsilon Receptor I Signaling in Mast CellsSignalingSMP00358
Gout or Kelley-Seegmiller SyndromeDiseaseSMP00365
Carvedilol Action PathwayDrug actionSMP00367
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)DiseaseSMP00369
Tyrosinemia Type 3 (TYRO3)DiseaseSMP00370
Isradipine Action PathwayDrug actionSMP00378
Prilocaine Action PathwayDrug actionSMP00401
Heroin Action PathwayDrug actionSMP00407
Methadone Action PathwayDrug actionSMP00408
Alfentanil Action PathwayDrug actionSMP00413
Carfentanil Action PathwayDrug actionSMP00414
Azathioprine Action PathwayDrug actionSMP00427
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinCalcium may increase the arrhythmogenic activities of Acetyldigitoxin.Approved
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium.Approved
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium is combined with Alfacalcidol.Approved, Nutraceutical
AmlodipineThe therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium.Approved
AmrinoneThe therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium.Approved
AnvirzelCalcium may increase the arrhythmogenic activities of Anvirzel.Investigational
AzelnidipineThe therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium.Approved
AzimilideThe therapeutic efficacy of Azimilide can be decreased when used in combination with Calcium.Investigational
BarnidipineThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium.Approved
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
BenidipineThe therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium.Approved
BepridilThe therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium.Approved, Withdrawn
CaiThe therapeutic efficacy of Cai can be decreased when used in combination with Calcium.Investigational
CalcidiolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcidiol.Approved, Nutraceutical
CalcipotriolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcipotriol.Approved
CalcitriolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe risk or severity of adverse effects can be increased when Calcium is combined with Calcium Acetate.Approved
CeftriaxoneThe risk or severity of adverse effects can be increased when Calcium is combined with Ceftriaxone.Approved
ChlorothiazideChlorothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
ChlortetracyclineThe serum concentration of Chlortetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
ChlorthalidoneChlorthalidone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
CholecalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Cholecalciferol.Approved, Nutraceutical
CilnidipineThe therapeutic efficacy of Cilnidipine can be decreased when used in combination with Calcium.Approved
CinnarizineThe therapeutic efficacy of Cinnarizine can be decreased when used in combination with Calcium.Approved
CinoxacinCalcium can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
CiprofloxacinCalcium can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
ClevidipineThe therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium.Approved
ClodronateThe serum concentration of Clodronate can be decreased when it is combined with Calcium.Approved, Investigational, Vet Approved
DarodipineThe therapeutic efficacy of Darodipine can be decreased when used in combination with Calcium.Experimental
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Calcium.Approved
DemeclocyclineThe serum concentration of Demeclocycline can be decreased when it is combined with Calcium.Approved
DeslanosideCalcium may increase the arrhythmogenic activities of Deslanoside.Approved
DigitoxinCalcium may increase the arrhythmogenic activities of Digitoxin.Approved
DigoxinCalcium may increase the arrhythmogenic activities of Digoxin.Approved
DihydrotachysterolThe risk or severity of adverse effects can be increased when Calcium is combined with Dihydrotachysterol.Approved
DiltiazemThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium.Approved
Dipotassium phosphateCalcium can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DobutamineThe therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Calcium.Approved
DotarizineThe therapeutic efficacy of Dotarizine can be decreased when used in combination with Calcium.Investigational
DoxercalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Doxercalciferol.Approved
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Calcium.Approved, Investigational, Vet Approved
EfonidipineThe therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium.Approved
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Calcium.Approved
EnoxacinCalcium can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
EperisoneThe therapeutic efficacy of Eperisone can be decreased when used in combination with Calcium.Approved, Investigational
ErgocalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Ergocalciferol.Approved, Nutraceutical
EstramustineCalcium can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Calcium.Approved
FelodipineThe therapeutic efficacy of Felodipine can be decreased when used in combination with Calcium.Approved, Investigational
FendilineThe therapeutic efficacy of Fendiline can be decreased when used in combination with Calcium.Withdrawn
FleroxacinCalcium can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FlumequineCalcium can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be decreased when used in combination with Calcium.Approved
GabapentinThe therapeutic efficacy of Gabapentin can be decreased when used in combination with Calcium.Approved, Investigational
GallopamilThe therapeutic efficacy of Gallopamil can be decreased when used in combination with Calcium.Investigational
GarenoxacinCalcium can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
GatifloxacinCalcium can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GemifloxacinCalcium can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GrepafloxacinCalcium can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
HydrochlorothiazideHydrochlorothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Calcium.Approved, Investigational
IndapamideIndapamide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
IsradipineThe therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium.Approved
LacidipineThe therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium.Approved
LamotrigineThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium.Approved, Investigational
LercanidipineThe therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium.Approved, Investigational
LevofloxacinCalcium can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium.Approved
Lipoic AcidCalcium can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Nutraceutical
LomefloxacinCalcium can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium SulfateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium.Approved, Vet Approved
ManidipineThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium.Approved
MethyclothiazideMethyclothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
MetolazoneMetolazone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
MibefradilThe therapeutic efficacy of Mibefradil can be decreased when used in combination with Calcium.Withdrawn
MinocyclineThe serum concentration of Minocycline can be decreased when it is combined with Calcium.Approved, Investigational
MoxifloxacinCalcium can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
NaftopidilThe therapeutic efficacy of Naftopidil can be decreased when used in combination with Calcium.Investigational
Nalidixic AcidCalcium can cause a decrease in the absorption of Nalidixic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NemonoxacinCalcium can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
NicardipineThe therapeutic efficacy of Nicardipine can be decreased when used in combination with Calcium.Approved
NifedipineThe therapeutic efficacy of Nifedipine can be decreased when used in combination with Calcium.Approved
NiguldipineThe therapeutic efficacy of Niguldipine can be decreased when used in combination with Calcium.Experimental
NiludipineThe therapeutic efficacy of Niludipine can be decreased when used in combination with Calcium.Experimental
NilvadipineThe therapeutic efficacy of Nilvadipine can be decreased when used in combination with Calcium.Approved
NimesulideThe therapeutic efficacy of Nimesulide can be decreased when used in combination with Calcium.Approved, Withdrawn
NimodipineThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium.Approved
NisoldipineThe therapeutic efficacy of Nisoldipine can be decreased when used in combination with Calcium.Approved
NitrendipineThe therapeutic efficacy of Nitrendipine can be decreased when used in combination with Calcium.Approved
NorfloxacinCalcium can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OfloxacinCalcium can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OuabainCalcium may increase the arrhythmogenic activities of Ouabain.Approved
OxytetracyclineThe serum concentration of Oxytetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Calcium.Approved
ParicalcitolThe risk or severity of adverse effects can be increased when Calcium is combined with Paricalcitol.Approved, Investigational
PazufloxacinCalcium can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
PefloxacinCalcium can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PerhexilineThe therapeutic efficacy of Perhexiline can be decreased when used in combination with Calcium.Approved
PinaveriumThe therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium.Approved
PolythiazidePolythiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
PregabalinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium.Approved, Illicit, Investigational
PrenylamineThe therapeutic efficacy of Prenylamine can be decreased when used in combination with Calcium.Withdrawn
PrulifloxacinCalcium can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
QuinethazoneQuinethazone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Calcium.Approved, Investigational
RosoxacinCalcium can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium glycerophosphateCalcium can cause a decrease in the absorption of Sodium glycerophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium phosphateCalcium can cause a decrease in the absorption of Sodium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SparfloxacinCalcium can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Strontium ranelateThe serum concentration of Strontium ranelate can be decreased when it is combined with Calcium.Approved
Technetium tc 99m etidronateThe serum concentration of Technetium tc 99m etidronate can be decreased when it is combined with Calcium.Approved
Technetium Tc-99m MedronateThe serum concentration of Technetium Tc-99m Medronate can be decreased when it is combined with Calcium.Approved
TemafloxacinCalcium can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Calcium.Approved
TiludronateThe serum concentration of Tiludronate can be decreased when it is combined with Calcium.Approved, Vet Approved
Tolfenamic AcidThe therapeutic efficacy of Tolfenamic Acid can be decreased when used in combination with Calcium.Approved
TranilastThe therapeutic efficacy of Tranilast can be decreased when used in combination with Calcium.Approved, Investigational
TrichlormethiazideTrichlormethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
TriethylenetetramineThe serum concentration of Triethylenetetramine can be decreased when it is combined with Calcium.Approved
TrovafloxacinCalcium can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
VerapamilThe therapeutic efficacy of Verapamil can be decreased when used in combination with Calcium.Approved
VinpocetineThe therapeutic efficacy of Vinpocetine can be decreased when used in combination with Calcium.Investigational
XylometazolineThe therapeutic efficacy of Xylometazoline can be decreased when used in combination with Calcium.Approved
ZiconotideThe therapeutic efficacy of Ziconotide can be decreased when used in combination with Calcium.Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Calcium.Approved
Food InteractionsNot Available
References
Synthesis ReferenceUS5667761
General References
  1. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6. [PubMed:9278463 ]
  2. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003548. [PubMed:16034903 ]
  3. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D: Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. [PubMed:16481635 ]
  4. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005 May 7-13;365(9471):1621-8. [PubMed:15885294 ]
  5. Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005 Apr 30;330(7498):1003. [PubMed:15860827 ]
External Links
ATC CodesM05BB02M05BB08M05BB04A11AA02M05BB05M05BB01
AHFS Codes
  • 34:00.00
  • 40:12.00
  • 40:18.17
  • 40:18.19
  • 40:34.00*
  • 56:04.00
  • 56:12.00
  • 88:08.00
  • 88:12.00
  • 88:29.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (25.6 KB)
MSDSDownload (47.9 KB)
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral.99 1/1
PowderOral
Granule, effervescent; kit; tabletOral
TabletOral166.6 mg
Capsule; liquidOral
TabletOral
PowderOral63.4 mg
PowderOral336 mg
TabletOral100 mg
TabletOral30 mg
WaferOral
CapsuleOral150 mg
TabletOral600 mg
TabletOral650 mg
CapsuleOral400 mg
TabletOral246 mg
CapsuleOral160.0 mg
TabletOral60 mg
TabletOral120 mg
CapsuleOral100 mg
TabletOral84.5 mg
TabletOral84 mg
LiquidOral100 mg
SyrupOral100 mg
SyrupOral110 mg
TabletOral150 mg
TabletOral125 mg
TabletOral266.7 mg
PowderOral216.7 mg
CapsuleOral500 mg
LiquidOral803.8 mg/1000mL
Powder, for solutionOral
TabletOral300 mg
CapsuleOral45 mg
TabletOral.99 1/1
TabletOral84.2 mg
TabletOral42.1 mg
LiquidIntravenous10 mg
LiquidOral
Liquid; tabletOral
Granule, effervescentOral
Kit; tabletOral
Capsule, gelatin coatedOral
CapsuleOral
TabletOral350 mg
TabletOral250 mg
Tablet, film coatedOral
Tablet, chewableOral
Tablet, effervescentOral
TabletOral200 mg
Tablet, extended releaseOral
SolutionOral1.458 mg
SolutionOral1.667 mg
TabletOral400 mg
LiquidOral400 mg
CapsuleOral600 mg
TabletOral500 mg
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point839°CMSDS
boiling point1484°CMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.0 mg/mLALOGPS
logP-1.3ALOGPS
logP-0.57ChemAxon
logS1.08ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular Weight:
248974.1 Da
References
  1. Boda D, Giri J, Henderson D, Eisenberg B, Gillespie D: Analyzing the components of the free-energy landscape in a calcium selective ion channel by Widom's particle insertion method. J Chem Phys. 2011 Feb 7;134(5):055102. doi: 10.1063/1.3532937. [PubMed:21303162 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Signal transducer activity
Specific Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Gene Name:
ATP2C1
Uniprot ID:
P98194
Molecular Weight:
100576.42 Da
References
  1. Shi X, Chen M, Huvos PE, Hardwicke PM: Amino acid sequence of a Ca(2+)-transporting ATPase from the sarcoplasmic reticulum of the cross-striated part of the adductor muscle of the deep sea scallop: comparison to serca enzymes of other animals. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):359-74. [PubMed:9787799 ]
  2. Bonza MC, Martin H, Kang M, Lewis G, Greiner T, Giacometti S, Van Etten JL, De Michelis MI, Thiel G, Moroni A: A functional calcium-transporting ATPase encoded by chlorella viruses. J Gen Virol. 2010 Oct;91(Pt 10):2620-9. doi: 10.1099/vir.0.021873-0. Epub 2010 Jun 23. [PubMed:20573858 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Calcium ion binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC2
Uniprot ID:
P02585
Molecular Weight:
18121.895 Da
References
  1. Martin SR, Avella G, Adrover M, de Nicola GF, Bullard B, Pastore A: Binding properties of the calcium-activated F2 isoform of Lethocerus troponin C. Biochemistry. 2011 Mar 22;50(11):1839-47. doi: 10.1021/bi102076s. Epub 2011 Feb 10. [PubMed:21250664 ]
  2. Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M: Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28. [PubMed:21035455 ]
  3. Robertson IM, Sun YB, Li MX, Sykes BD: A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. J Mol Cell Cardiol. 2010 Dec;49(6):1031-41. doi: 10.1016/j.yjmcc.2010.08.019. Epub 2010 Aug 27. [PubMed:20801130 ]
  4. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Troponin t binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC1
Uniprot ID:
P63316
Molecular Weight:
18402.36 Da
References
  1. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
  2. Swindle N, Tikunova SB: Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C. Biochemistry. 2010 Jun 15;49(23):4813-20. doi: 10.1021/bi100400h. [PubMed:20459070 ]
  3. Parvatiyar MS, Pinto JR, Liang J, Potter JD: Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C. J Biol Chem. 2010 Sep 3;285(36):27785-97. doi: 10.1074/jbc.M110.112326. Epub 2010 Jun 21. [PubMed:20566645 ]
  4. Baylor SM, Hollingworth S: Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling. Prog Biophys Mol Biol. 2011 May;105(3):162-79. doi: 10.1016/j.pbiomolbio.2010.06.001. Epub 2010 Jun 25. [PubMed:20599552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Structural constituent of cytoskeleton
Specific Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Gene Name:
SPTBN1
Uniprot ID:
Q01082
Molecular Weight:
274606.995 Da
References
  1. Wallis CJ, Wenegieme EF, Babitch JA: Characterization of calcium binding to brain spectrin. J Biol Chem. 1992 Mar 5;267(7):4333-7. [PubMed:1537825 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within...
Gene Name:
S100B
Uniprot ID:
P04271
Molecular Weight:
10712.985 Da
References
  1. Lee TS, Mane S, Eid T, Zhao H, Lin A, Guan Z, Kim JH, Schweitzer J, King-Stevens D, Weber P, Spencer SS, Spencer DD, de Lanerolle NC: Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med. 2007 Jan-Feb;13(1-2):1-13. [PubMed:17515952 ]
  2. Marlatt NM, Shaw GS: Amide exchange shows calcium-induced conformational changes are transmitted to the dimer interface of S100B. Biochemistry. 2007 Jun 26;46(25):7478-87. Epub 2007 May 31. [PubMed:17536784 ]
  3. Liang J, Luo G, Ning X, Shi Y, Zhai H, Sun S, Jin H, Liu Z, Zhang F, Lu Y, Zhao Y, Chen X, Zhang H, Guo X, Wu K, Fan D: Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein. Biochem Cell Biol. 2007 Jun;85(3):375-83. [PubMed:17612632 ]
  4. Friel LA, Romero R, Edwin S, Nien JK, Gomez R, Chaiworapongsa T, Kusanovic JP, Tolosa JE, Hassan SS, Espinoza J: The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35(5):385-93. [PubMed:17624933 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Poly(a) rna binding
Specific Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Gene Name:
CAST
Uniprot ID:
P20810
Molecular Weight:
76572.035 Da
References
  1. Hanna RA, Garcia-Diaz BE, Davies PL: Calpastatin simultaneously binds four calpains with different kinetic constants. FEBS Lett. 2007 Jun 26;581(16):2894-8. Epub 2007 May 25. [PubMed:17543955 ]
  2. De Tullio R, Averna M, Stifanese R, Parr T, Bardsley RG, Pontremoli S, Melloni E: Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons. Arch Biochem Biophys. 2007 Sep 1;465(1):148-56. Epub 2007 May 30. [PubMed:17570336 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both pr...
Gene Name:
COMP
Uniprot ID:
P49747
Molecular Weight:
82859.88 Da
References
  1. Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 2007 Aug 24;282(34):24591-8. Epub 2007 Jun 22. [PubMed:17588949 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Titin binding
Specific Function:
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Gene Name:
CALM1
Uniprot ID:
P62158
Molecular Weight:
16837.47 Da
References
  1. Sosa V, Carbo R, Guarner V: Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia. Eur J Pharmacol. 2007 Jul 30;568(1-3):83-8. Epub 2007 Apr 30. [PubMed:17537429 ]
  2. Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y: The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem. 2007 Aug 10;282(32):23737-44. Epub 2007 Jun 5. [PubMed:17550897 ]
  3. Schallreuter KU, Gibbons NC, Zothner C, Abou Elloof MM, Wood JM: Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun. 2007 Aug 17;360(1):70-5. Epub 2007 Jun 11. [PubMed:17592724 ]
  4. Caride AJ, Filoteo AG, Penniston JT, Strehler EE: The plasma membrane Ca2+ pump isoform 4a differs from isoform 4b in the mechanism of calmodulin binding and activation kinetics: implications for Ca2+ signaling. J Biol Chem. 2007 Aug 31;282(35):25640-8. Epub 2007 Jun 26. [PubMed:17595168 ]
  5. Lo LW, Chen YC, Chen YJ, Wongcharoen W, Lin CI, Chen SA: Calmodulin kinase II inhibition prevents arrhythmic activity induced by alpha and beta adrenergic agonists in rabbit pulmonary veins. Eur J Pharmacol. 2007 Oct 1;571(2-3):197-208. Epub 2007 Jun 13. [PubMed:17612522 ]
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Drug created on July 06, 2007 14:28 / Updated on August 17, 2016 12:23