Identification
NameCalcium
Accession NumberDB01373
TypeSmall Molecule
GroupsNutraceutical
Description

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.

Structure
Thumb
SynonymsNot Available
External IDs Not Available
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Leucovorin Ca Inj (pharm. Bulk Vial) 10mg/mlLiquid10 mgIntravenousDavid Bull Laboratories (Pty) Ltd.1992-12-311997-08-14Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bakanasan Calcium Citrate PowderPowder63.4 mgOralRheingold Food International Ltd.1995-12-311999-08-03Canada
Biocalth Calcium PowderPowder336 mgOralBiocalth International Corporation2003-05-102006-07-31Canada
Biocalth Calcium SupplementTablet100 mgOralBiocalth International Corporation2002-10-152006-07-31Canada
Bodysmarts With CalciumTablet30 mgOralCadbury Adams Canada Inc.2001-02-192005-07-28Canada
Cal 500 Tab 500mgTablet500 mgOralBioforce Canada Inc.1985-12-311997-04-04Canada
Cal Gel Cap 45mgCapsule45 mgOralLaboratoire Lalco Inc.1977-12-311997-07-31Canada
Cal Supp 500Tablet500 mgOralWn Pharmaceuticals Ltd.2002-06-062006-08-08Canada
Cal Supp 500 - TabTablet500 mgOralVita Health Products Inc1996-10-112008-08-05Canada
Cal-citrusTablet200 mgOralSterimax Inc1996-09-102006-10-20Canada
CalciumTablet500 mgOralHealth Wise Nutrition Inc.2000-04-042002-07-18Canada
CalciumCapsule150 mgOralSeroyal International Inc.1996-12-312009-07-06Canada
Calcium 350 Mg (calcium Citrate) - CapletTablet350 mgOralVita Health Products Inc1996-10-112007-07-30Canada
Calcium 350 Mg (calcium Citrate) CapletTablet350 mgOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012008-07-07Canada
Calcium 350mgTablet350 mgOralGeneral Nutrition Canada Inc.2001-10-202009-08-05Canada
Calcium 500 mgTablet500 mgOralNutricorp International2001-11-012007-08-01Canada
Calcium 600Tablet600 mgOralLaboratoire Riva Inc2001-01-152008-08-11Canada
Calcium 600mg Dietary SupplementTablet600 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Calcium 650mgTablet650 mgOralNutricorp International1999-12-152007-08-01Canada
Calcium 650mg TabTablet650 mgOralJamieson Laboratories Ltd1994-12-312006-07-25Canada
Calcium Caps 400mgCapsule400 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium CarbonateTablet500 mgOralVita Health Products Inc1985-12-312004-07-26Canada
Calcium Carbonate 1500mgTablet600 mgOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Calcium Carbonate TabTablet246 mgOralSwiss Herbal Remedies Ltd.1989-12-311998-07-15Canada
Calcium CitramateCapsule160.0 mgOralThorne Research Inc.1997-04-182006-08-04Canada
Calcium CitrateTablet350 mgOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Calcium CitrateTablet200 mgOralVita Health Products Inc1998-01-132004-07-26Canada
Calcium Citrate 300mgTablet300 mgOralWn Pharmaceuticals Ltd.1998-06-192008-07-17Canada
Calcium Gluconate Tablets USP 650 mgTablet60 mgOralPharmetics (2011) Inc.2002-03-102006-07-27Canada
Calcium Lactate 650mgTablet120 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Calcium Lactate CapsCapsule100 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium Lactate Tab 84.5mgTablet84.5 mgOralLaboratoire Lalco Inc.1980-12-311997-07-31Canada
Calcium Lactate Tablets USP 650 mgTablet84 mgOralPharmetics (2011) Inc.2002-03-102006-07-27Canada
Calcium LiquidLiquid100 mgOralPharmetics (2011) Inc.2002-09-302009-07-30Canada
Calcium Liquid SyrupSyrup100 mgOralSupplements Aromatik Inc.2003-07-022008-08-01Canada
Calcium Sandoz Syr 110mg/5mlSyrup110 mgOralNovartis1995-12-311999-07-21Canada
Calcium Syrup 110mg/5mlSyrup110 mgOralVita Health Products Inc1990-12-312002-07-31Canada
Calsan Chewable Tab 500mgTablet500 mgOralNovartis1986-01-012008-07-15Canada
Chelated Calcium Supplement - 150mg TabTablet150 mgOralAlbion1996-09-062002-07-12Canada
Chelazome Calcium 125mgTablet125 mgOralTrophic Canada Ltd.1987-12-312000-08-03Canada
Children's Chewable Calcium (chewable Tablets)Tablet266.7 mgOralGeneral Nutrition Canada Inc.1998-11-232007-08-01Canada
Coral CalciumPowder216.7 mgOralNatures Sunshine Products, Inc.2003-12-012007-07-30Canada
Dia Cal Cap 500mgCapsule500 mgOralR & D Laboratories Inc.1991-12-312003-07-16Canada
Extra Strength Calcium Antacid ChewableTablet300 mgOralPerrigo International1996-12-311998-08-12Canada
Gellucal Cap 45mgCapsule45 mgOralVitalab1990-12-311996-09-09Canada
Hi Potency Cal Tab 650mgTablet650 mgOralSwiss Herbal Remedies Ltd.1986-12-311997-07-28Canada
Lactate De Calcium 648 mgTablet84.2 mgOralGamme Nature1990-12-312008-07-31Canada
Lactate De Calcium Tab 42.1mgTablet42.1 mgOralLe Naturiste J.M.B. Inc.1980-12-311997-07-23Canada
Mor-cal Tab 500mgTablet500 mgOralPharmetics (2011) Inc.1986-12-312006-07-27Canada
Nutrol-cal Tab 875mgTablet350 mgOralRolmex International Inc.1990-12-311997-08-08Canada
Os-cal 250 mgTablet250 mgOralWyeth Ltd.1994-12-312003-07-28Canada
Os-cal 500Tablet500 mgOralWyeth Ltd.1993-12-312008-12-16Canada
Os-cal 500 Chewable Tab 500mgTablet500 mgOralWyeth Ayerst Canada Inc.1996-09-301998-01-28Canada
Os-cal 500 Chewable Tab 500mgTablet500 mgOralAyerst Laboratories1986-12-311997-08-15Canada
Pharmacal 500 Tab 500mgTablet500 mgOralPharmadex Laboratories Inc.1993-12-311999-08-28Canada
Prevencal Tab 500mgTablet500 mgOralLaboratoire Lalco Inc.1988-12-311997-07-31Canada
Regular Strength Calcium Antacid Chew. TabsTablet200 mgOralPerrigo International1996-12-311998-08-12Canada
Soluble Calcium Citrate 1200mgTablet250 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tropicana Calcium Supplement 344 mgSolution1.458 mgOralTropicana Canada2002-01-142007-06-21Canada
Tropicana Calcium Supplement 393 mgSolution1.667 mgOralTropicana Canada2002-02-182007-06-21Canada
Tropicana Calcium Supplement 604 mgSolution1.458 mgOralTropicana Canada2003-02-072007-06-21Canada
Tums 500 TabTablet500 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311996-09-12Canada
Tums Extra Strength Assorted Tropical FruitTablet300 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-09-101998-08-25Canada
Tums Ultra Strength Assorted Mint FlavoursTablet400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-12-311998-08-25Canada
Tums Ultra Strength Assorted Tropical FruitTablet400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-07-311998-08-25Canada
Tums Ultra Strength LiquidLiquid400 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-04-172001-07-31Canada
Vitamine C Cap 600mgCapsule600 mgOralSisu Inc.1989-12-312008-07-25Canada
Webber Calcium Tab 500mgTablet500 mgOralNovartis1985-12-311998-07-08Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7030 Calcium GoldCapsule.99 1/1OralApexel Co., Ltd.2013-03-10Not applicableUs
7030 Calcium PremiumCapsule.99 1/1OralApexel Co., Ltd.2013-03-10Not applicableUs
ENA Actimineral ALiquid803.8 mg/1000mLOralJinju Bio Food2013-06-28Not applicableUs
HANTAI 8030 Ca-D3 GOLDTablet.99 1/1OralApexel Co., Ltd.2015-05-18Not applicableUs
HANTAI 8030 Ca-D3 PremiumTablet.99 1/1OralApexel Co., Ltd.2015-05-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A D Calcium TabTabletOralStar Pharmaceuticals, Llc1979-12-311999-07-21Canada
A-D Calcium CapCapsuleOralVitalab1990-12-312005-07-12Canada
A.R.T.H. Away FormulaCapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Act EtidrocalTabletOralActavis Pharma Company2008-04-10Not applicableCanada
Acti-cal/mag 2:1 + Zinc and D CapletTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-megascorb Crystals PwrPowderOralActi Form Ltd.1991-12-312005-03-21Canada
Actical Plus Calcium-magnesium-vitamin D3-silicon ChewableTabletOralUsana Health Sciences, Inc.1999-09-302004-07-27Canada
Active Calcium Plus Magnesium, Vitamin D and SiliconTabletOralUsana Health Sciences, Inc.2002-07-082007-07-18Canada
Actonel Plus CalciumTabletOralWarner Chilcott2006-05-182015-11-19Canada
Actonel Sachet KitGranule, effervescent; Kit; TabletOralWarner ChilcottNot applicableNot applicableCanada
Ad & Calcium CapCapsuleOralLaboratoire Lalco Inc.1977-12-312001-10-15Canada
Ad Calcium CapCapsuleOralLes Produits Gerbex Inc.1979-12-311997-08-11Canada
Alsimine W Vitamins A DCapsule; LiquidOralAlsi Cie Ltee1978-12-312003-05-21Canada
Astral C TabTabletOralAlbi Naturals1994-12-312008-07-17Canada
Avon Nutrivance Soft Calcium Chews With Vitamin DTablet, chewableOralAvon Products, Inc.2004-01-052006-07-14Canada
B & J Formula Dietary SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
B-NexaTabletOralUpsher Smith Laboratories2011-12-08Not applicableUs
BaisixTabletOralProdemdis Enr.Not applicableNot applicableCanada
BseltzerGranule, effervescentOralAbundance Marketing Ltd.2001-11-112007-07-23Canada
Buffered Vitamin C Powder With Ca Mg and KPowderOralThorne Research Inc.1997-04-182005-06-21Canada
Buffered Vitamin C Pwr W Cal-mag-potassiumPowderOralSisu Inc.1987-12-312009-08-04Canada
C-crystals With CalciumPowderOralAlive Vitamins1985-12-311997-08-11Canada
C.H.V. FormulaCapsuleOralNihon Kenko Zoushin Kenkyukai Canada Inc., Subsidery Of Nikken Usa Inc.1999-09-252005-07-15Canada
Cal & Mag Hvp Chel Plus C Potass & Zinc TabTabletOralGahler Enterprises Ltd.1989-12-312000-09-05Canada
Cal M TabTabletOralAnabolic Laboratories Inc.1978-12-312004-03-15Canada
Cal Mag Drink With Vitamin CPowderOralWampole Brands2003-01-012004-06-29Canada
Cal Mag Plus - TabTabletOralNutrilite, A Division Of Access Business Group, Llc1995-12-312007-07-06Canada
Cal Mag TabTabletOralSwiss Herbal Remedies Ltd.1982-12-311999-09-09Canada
Cal-mag (one To One) With Potass & ZincTabletOralGahler Enterprises Ltd.1988-12-311999-01-27Canada
Cal-mag Citrate Zinc & Vitamin D TabletsTabletOralSwiss Herbal Remedies Ltd.Not applicableNot applicableCanada
Cal-mag Complete With Zinc, C and DTabletOralQuest Vitamins A Div Of Purity Life Health Products1992-12-312009-07-14Canada
Cal-mag Plus K, Mn and Zn CapletsTabletOralHealth Wise Nutrition Inc.1994-12-311999-08-13Canada
Cal-mag TabletTabletOralStandard Process Inc.Not applicableNot applicableCanada
Cal-mag Vitamin C and Zinc TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312004-09-03Canada
Cal-mag With Vitamin DTabletOralAlbi Imports Ltd.1990-12-312005-09-20Canada
Cal-mag With Zinc & Vitamin DTabletOralHealth Wise Nutrition Inc.2000-06-092002-07-18Canada
Cal/mag 1:1 With Zinc and Vitamin D - TabletTabletOralHealth Wise Nutrition Inc.1997-08-152002-07-18Canada
Cal/mag 2:1 With DTabletOralWn Pharmaceuticals Ltd.1998-06-262000-02-02Canada
Cal/mag+dTabletOralSeroyal International Inc.1989-12-312009-07-06Canada
Calburst Calcium 500mg With Vitamin DWaferOralPharmavite2000-03-202004-07-20Canada
Calci-yum Plus Magnesium + D3TabletOralNu Life Nutrition Ltd.1987-12-312000-05-23Canada
Calcimag TabTabletOralLes Produits Naturels Suisse Inc.1985-12-311996-09-09Canada
CalcitolCapsuleOralFrega Inc.1979-12-312001-08-09Canada
Calcium Mg and Zn Capsules With Vitamin DCapsuleOralRheingold Food International Ltd.1995-12-312007-07-26Canada
Calcium & Magnesium Citrate Plus D With Manganese, Potassium & ZincTabletOralNatural Factors Nutritional Products Ltd.1998-12-142008-07-17Canada
Calcium & Magnesium Plus Potassium & ZincTabletOralNatural Factors Nutritional Products Ltd.1998-12-212009-09-28Canada
Calcium & Magnesium Plus Potassium, Zinc, & ManganeseCapsuleOralNatural Factors Nutritional Products Ltd.2000-04-272008-07-17Canada
Calcium & Magnesium TabTabletOralBioforce Canada Inc.1985-12-311997-12-02Canada
Calcium & Magnesium TabletsTabletOralVita Health Products Inc1997-09-082007-07-30Canada
Calcium & Magnesium With Potassium & ZincTabletOralWn Pharmaceuticals Ltd.2000-08-302005-08-15Canada
Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin DTabletOralWn Pharmaceuticals Ltd.2000-08-302005-08-15Canada
Calcium & Magnesium With Vitamin DCapsuleOralOrganika Health Products Inc.1998-09-282009-08-05Canada
Calcium & Vitamin DCapsuleOralQuantofill Inc.Not applicableNot applicableCanada
Calcium 250 Mg With Vitamin DTabletOralGfr Pharma Ltd.2002-10-102008-07-17Canada
Calcium 400 With Magnesium - PwrPowderOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
Calcium 500 With Vitamin D TabTabletOralVita Health Products Inc1992-12-312006-07-31Canada
Calcium 500mg With Vitamin DTabletOralNutricorp International2001-11-012007-08-01Canada
Calcium 600 + DTabletOralLaboratoire Riva Inc2001-01-152008-08-11Canada
Calcium 600 + D ComprimesTabletOralNobel Pharm Enr.1989-12-311997-07-31Canada
Calcium 600mg + Vit D3 125unit TabTabletOralPharmetics (2011) Inc.1994-12-312009-07-30Canada
Calcium 650mg With Vitamin DTabletOralNutricorp International2000-08-012007-08-01Canada
Calcium A DTabletOralPhyto Health Corporation1973-12-312003-11-03Canada
Calcium and Mag-potass and Zinc CapCapsuleOralGahler Enterprises Ltd.1991-12-312001-07-26Canada
Calcium and Magnesium 1:1 Plus TabletsTabletOralAlbi Naturals1998-02-202009-07-15Canada
Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iuTabletOralWn Pharmaceuticals Ltd.2001-11-232002-05-15Canada
Calcium and Magnesium Citrate With Vitamin DTabletOralSisu Inc.1997-10-282005-07-13Canada
Calcium and Magnesium TabTabletOralAlbi Imports Ltd.1981-12-312004-09-24Canada
Calcium and Magnesium TabletsTabletOralVitazan Herbs & Vitamins Inc.1997-09-042008-07-23Canada
Calcium and Magnesium W Zinc TabTabletOralPharmavite1987-12-312005-07-15Canada
Calcium and Magnesium With Vitamin DTabletOralVita Health Products Inc1998-09-152002-07-31Canada
Calcium and Magnesium With ZincTabletOralVita Health Products Inc1998-09-152002-07-31Canada
Calcium and Vitamin D - Soft ChewTabletOralVita Health Products Inc2001-09-012004-07-26Canada
Calcium Ascorbate 1000 Mg - TabletTabletOralHealth Wise Nutrition Inc.1997-08-152000-07-29Canada
Calcium Ascorbate Cap 850mgCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1984-12-312001-07-06Canada
Calcium Ascorbate PowderPowderOralEster C Health Co, Division Of Inter Cal Corp1987-12-311998-09-02Canada
Calcium Ascorbate Tab 550mgTabletOralEster C Health Co, Division Of Inter Cal Corp1987-12-311998-09-02Canada
Calcium Caps Plus MagnesiumCapsuleOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Calcium Capsules With Magnesium and Vitamin DCapsuleOralHerba Lab Inc.2003-04-222007-07-26Canada
Calcium Carbonate + Vitamin DTabletOralWn Pharmaceuticals Ltd.2002-04-152009-08-27Canada
Calcium Carbonate Tablets With Vitamin DTabletOralVita Health Products Inc1996-10-112006-07-31Canada
Calcium Chelate Plus Vit DTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Calcium Citrate and Vitamin D 200mg/160iuCapsuleOralWn Pharmaceuticals Ltd.2001-11-302002-07-07Canada
Calcium Citrate With Vitamin DTabletOralWn Pharmaceuticals Ltd.2001-11-232007-08-07Canada
Calcium Complex High GradeCapsuleOralNew Spirit Naturals, Inc.Not applicableNot applicableCanada
Calcium Et Magnesium Plus Vitamin DTabletOralLaboratoire Lalco Inc.Not applicableNot applicableCanada
Calcium Et Magnesium Plus Vitamine D/fe/znTabletOralLaboratoire Lalco Inc.1993-12-312008-07-29Canada
Calcium Et Magnesium TabTabletOralLaboratoire Lalco Inc.1992-12-312006-09-07Canada
Calcium Lactate PowderPowderOralStandard Process Inc.Not applicableNot applicableCanada
Calcium Magnesium 1000/500 - TabTabletOralPro Shop Inc.1995-12-312004-08-05Canada
Calcium Magnesium 2:1 Tablets With Vitamin DTabletOralSisu Inc.2004-01-302009-08-04Canada
Calcium Magnesium Avec Vitamine CTabletOralLes Aliments Nutri Source Inc.1989-12-312009-08-05Canada
Calcium Magnesium Avec Vitamine D Et ZincTabletOralLes Aliments Nutri Source Inc.1991-12-311996-09-09Canada
Calcium Magnesium Sulfur Silicon - TabTabletOralPro Shop Inc.1995-12-312000-07-31Canada
Calcium Magnesium TabTabletOralNutricorp International1994-12-312009-08-05Canada
Calcium Magnesium Tablets Nu LifeTabletOralNu Life Nutrition Ltd.1963-12-312000-05-23Canada
Calcium Magnesium With Potassium TabTabletOralNutrition For Life International1996-11-271998-09-01Canada
Calcium PlusTabletOralLaboratoire Riva IncNot applicableNot applicableCanada
Calcium Tab W Vit DTabletOralShoppers Drug Mart Inc.1981-12-311997-08-15Canada
Calcium With Magnesium and Vitamin DTabletOralGeneral Nutrition Canada Inc.2000-08-012000-10-23Canada
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DTabletOralJamieson Laboratories Ltd1993-12-312001-09-14Canada
Calcium With Vitamin D 200 Mg/160 IuCapsuleOralWn Pharmaceuticals Ltd.2002-07-072007-08-07Canada
Calcium With Vitamin D2CapsuleOralSisu Inc.2002-12-182008-07-25Canada
Calcium With Vitamins C and D TabTabletOralPure Life International Prods Inc.1993-12-312000-07-27Canada
Calcium-magnesium Cap 1:1 W Vitamin DCapsuleOralSisu Inc.1988-12-312008-07-25Canada
Calcium-magnesium With K & Zn and Vitamin D3CapsuleOralHolista Health (Canada) Inc.1997-08-152002-08-06Canada
Calcium, Magnesium, Zinc and DCapsuleOralNutravite Pharmaceuticals Inc.1999-08-032007-07-17Canada
Calcium/magnesium DrinkPowderOralNew Vision Nutritionals Company1999-04-012002-11-20Canada
Calcium/magnesium Supplement TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Calcium/magnesium/vitamin D - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
CalcorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
Calma-DTabletOralWn Pharmaceuticals Ltd.1999-01-212009-09-28Canada
CalmaxPowderOralMedia Power, Inc.2001-08-202009-09-04Canada
CalplusTabletOralLifestyles Canada Corporation1998-08-072000-07-16Canada
Caltrate 600 Plus D - TabletTabletOralWhitehall Robins Inc.1985-12-312001-08-07Canada
Cell-wiseTabletOralMelaleuca, Inc.1998-01-122004-07-30Canada
Cell-wise Natural SourceTabletOralMelaleuca, Inc.1998-05-262005-06-28Canada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chela Calmag-100 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chela Calmag-300 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chelated Cal-mag(2:1)with Zn Vit.c and DTabletOralHealth Wise Nutrition Inc.1995-12-312002-07-18Canada
Chelated Cal/mag/zn With VitaminsTabletOralHealth Wise Nutrition Inc.2000-04-072002-07-18Canada
Chelated Calcium and Magnesium TabTabletOralAlive Vitamins1984-12-312000-07-13Canada
Chewable Cal-mag Chocolate FlavourTabletOralViva Life Science, Inc.1997-04-012009-09-29Canada
Chewable Calcium & Magnesium 2:1 TabletTabletOralSwiss Herbal Remedies Ltd.2000-04-182009-08-04Canada
Chewable Calcium 500 Mg With Vitamin D 200 IuTabletOralVita Health Products Inc2005-01-102008-08-05Canada
Chewable Calcium Plus Magnesium and MineralsTabletOralNatures Sunshine Products, Inc.1998-01-262002-08-23Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Chromium Gtf + CalciumTabletOralWeider Nutrition Group (Canada) Ltd.1998-05-052001-07-23Canada
Citrate De Calcium Plus Vitamine D Et ZincTabletOralSantÉ Naturelle (Ag) LtÉe2000-06-282003-07-10Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Coral Calcium Plus Vitamin DCapsuleOralHolista Health (Canada) Inc.2003-10-292009-09-28Canada
Coral Calcium Plus Vitamin D 210mg/100iuCapsuleOralWn Pharmaceuticals Ltd.2004-12-012009-09-28Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
DidrocalKit; TabletOralWarner Chilcott1995-12-312015-11-19Canada
Dol Mite TabTabletOralSwiss Herbal Remedies Ltd.1980-12-312006-07-25Canada
Dolomite 1280mgTabletOralRay IrastorzaNot applicableNot applicableCanada
Eden With Calcium and Vitamin DTabletOralWarner Lambert Canada Inc.Not applicableNot applicableCanada
Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mgTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Effervescent Vitamin C Powder With Ca and mgPowderOralThorne Research Inc.1997-04-182005-06-21Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
Ester C 500 TabTabletOralNu Life Nutrition Ltd.1997-08-152005-03-15Canada
Ester C Calcium Ascorbate CapCapsuleOralNatrol, Inc.1991-12-312007-10-01Canada
Ester C CapsuleCapsuleOralNatural Factors Nutritional Products Ltd.1998-01-222002-04-23Canada
Ester C PowderPowderOralNatural Factors Nutritional Products Ltd.1997-12-232001-07-26Canada
Ester C Tab ChewableTabletOralNatrol, Inc.1991-12-312001-07-30Canada
Ester C Vitamin C and Calcium PwsPowder, for solutionOralNatrol, Inc.1990-12-312007-10-01Canada
Ester-CCapsuleOralNatural Factors Nutritional Products Ltd.2002-04-232008-07-17Canada
Ester-C 500 mgTabletOralWn Pharmaceuticals Ltd.2000-05-102008-07-17Canada
Ester-C 600 mgCapsuleOralWn Pharmaceuticals Ltd.2000-06-012007-08-07Canada
Ester-C 787mgCapsuleOralNatural Factors Nutritional Products Ltd.2004-01-202008-07-17Canada
Ester-C Calcium Ascor TabTabletOralNatrol, Inc.1991-12-312007-10-01Canada
Ester-C Calcium Ascorbate CapsulesCapsuleOralSwiss Herbal Remedies Ltd.1995-12-312009-08-04Canada
Ester-C Calcium Ascorbate TabTabletOralNatrol, Inc.1991-12-312001-07-30Canada
Ester-C Calcium Ascorbate TabletsTabletOralSwiss Herbal Remedies Ltd.1995-12-312009-08-04Canada
Ester-C PowderPowderOralNatural Factors Nutritional Products Ltd.2000-05-162002-08-02Canada
Ester-C TabletTabletOralNatural Factors Nutritional Products Ltd.1999-12-062003-07-22Canada
Ester-C Vitamin C With CalciumCapsuleOralDarwen Holdings Ltd.Not applicableNot applicableCanada
EtidrocalTabletOralSanis Health Inc2010-07-26Not applicableCanada
Fb FormulaTabletOralWeider Nutrition Group (Canada) Ltd.1998-05-052001-07-23Canada
FemidauseCapsuleOralPns Pharma Therapy1999-02-022009-08-05Canada
Feminex 300 TabTabletOralSantÉ Naturelle (Ag) LtÉe1986-12-311997-09-09Canada
Feminique W Iron and Calcium TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-311998-08-13Canada
Ferrous SulfateTabletOralMartin Ekwealor Pharmaceuticals, Inc.2014-09-01Not applicableUs
Flex CapsulesCapsuleOralFoodscience Laboratories, Division Of Foodscience Corporation1998-07-022006-06-16Canada
Folcaps Omega-3Capsule, gelatin coatedOralMidlothian Laboratories2011-01-03Not applicableUs
Formula 2025 TabTabletOralStandard Process Inc.Not applicableNot applicableCanada
Formula 9 TabTabletOralPure Life International Prods Inc.1992-12-312001-08-07Canada
Formula A.R.-th Dietary SupplementCapsuleOralRx Vitamins Inc.2004-04-042007-10-25Canada
Formula ECTabletOralBody Wise International LlcNot applicableNot applicableCanada
Formula InfCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula IntCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula O-care Vitamin and Mineral SupplementTabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Formula OsgTabletOralSeroyal International Inc.1994-12-312000-08-08Canada
Fusion Activator Formula TabTabletOralL & S Research Corporation1993-12-311996-09-09Canada
Fusion PM Formula TabTabletOralL & S Research Corporation1993-12-311996-09-09Canada
G.A.S. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Good Night/pm Formula TabTabletOralNikken Usa, Incorporated1995-12-312002-06-26Canada
Hemarexin TabTabletOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1997-12-172004-08-03Canada
Hormodausse Plus Calc Et D TabTabletOralLaboratoires Charton Laboratories1988-12-311999-01-16Canada
Hvp Chelated Cal/mag With Zinc and Vitamins C and DTabletOralDarwen Holdings Ltd.Not applicableNot applicableCanada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
IpricalTabletOralPep Products Inc.1999-03-142003-01-13Canada
Isotonix Calcium Plus FormulaPowderOralMarket America1998-12-172001-06-28Canada
J.T. FormulaTabletOralChanges InternationalNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
L.G.I.T.CapsuleOralMorinda Canada1999-12-152001-07-23Canada
Liqui Cal-DLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
LiquicalLiquidOralLand Art Inc.2003-05-172008-06-26Canada
Liquid Cal-magLiquidOralSeroyal International Inc.1989-12-312009-07-06Canada
Liquid Cal/mag Plus DLiquidOralGahler Enterprises Ltd.1991-12-312002-07-17Canada
Liquid Calcium and Magnesium With Vit.dLiquidOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Liquid Calcium With Vitamin DCapsuleOralT & T Nutrition Inc.Not applicableNot applicableCanada
Lysamine Diet Supp Amp-tabLiquid; TabletOralWelcker Lyster Ltd., Division Of Technilab Inc.1983-12-311999-09-17Canada
Mag/cal 1:1 Capsules W Vitamin DCapsuleOralRheingold Food International Ltd.1990-12-312007-07-26Canada
MagnacalCapsuleOralHolista Health (Canada) Inc.1996-11-012002-08-06Canada
Menocal TabTabletOralLes Aliments Nutri Source Inc.1994-12-312009-08-05Canada
Mid-life Magnacal 2CapsuleOralHolista Health (Canada) Inc.1999-08-192002-08-06Canada
Milk Calcium With Vitamins C, D, and PhosphorousTabletOralQuest Vitamins A Div Of Purity Life Health Products2000-10-012006-07-25Canada
Min-tran TabTabletOralStandard Process Inc.Not applicableNot applicableCanada
Mnps Formula SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Mor-vites TabTabletOralPharmetics (2011) Inc.1992-12-312006-07-27Canada
Multi RolLiquid; TabletOralRolmex International Inc.1975-12-311997-08-08Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
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Multimineral ChelatesTabletOralW.R. Enterprises Inc.1984-12-312002-08-01Canada
Multiple Vitamin Plus Minerals TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins and Minerals TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Multiple Vitamins W Minerals TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-312002-07-31Canada
Multiple Vitamins With Minerals TabletsTabletOralPharmetics (2011) Inc.1999-07-162009-07-30Canada
Multivitamines Et MinerauxTabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Mylan-eti-cal CarepacKit; TabletOralMylan Pharmaceuticals2008-04-102017-01-09Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Natelle OneCapsule, gelatin coatedOralMeda Pharmaceuticals Ltd2015-02-01Not applicableUs
Nexa PlusCapsuleOralUpsher Smith Laboratories2012-08-01Not applicableUs
Nexa Select Rx Prenatal Vitamin with Plant-Based DHACapsuleOralUpsher Smith Laboratories2012-12-17Not applicableUs
Novo-etidronatecalKit; TabletOralTeva2009-06-15Not applicableCanada
Ntp-etidronate CalciumKit; TabletOralTevaNot applicableNot applicableCanada
Nutravite Calcium Magnesium and Zinc CapsCapsuleOralNutravite Pharmaceuticals Inc.1998-08-251999-08-07Canada
Nutri-chem Cal MagCapsuleOralNutri Chem Pharmacy Ltd1998-03-052008-08-13Canada
Nutri-chem Calcium Magnesium With D and ZincTabletOralNutri Chem Pharmacy Ltd2001-08-272009-08-19Canada
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
O Calcium 500mg Plus D TabTabletOralVita Health Products Inc1991-12-312006-07-31Canada
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
O-calcium 250mg Plus DTabletOralVita Health Products Inc1987-12-312005-07-20Canada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day Bone BuilderTabletOralBayer Inc Consumer Care2000-09-272003-07-29Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Opti-cal Chewable +d CapletTabletOralNu Life Nutrition Ltd.1991-12-312000-05-23Canada
Orange Flavored Crystal Chews TabTabletOralJeunique International Inc.1998-02-172006-07-20Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Os-cal-D 500TabletOralWyeth Ltd.1993-12-312008-12-16Canada
Osteo FormulaTabletOralNutramed Laboratories Inc.Not applicableNot applicableCanada
Osteo Formula TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1994-12-312006-07-25Canada
Osteo TabletsTabletOralQuest Vitamins A Div Of Purity Life Health Products1995-12-312000-07-20Canada
Osteo-lifeTabletOralViva Pharmaceutical Inc.2001-09-012009-12-18Canada
Osteo-plusTabletOralRolmex International Inc.2000-09-152008-07-09Canada
Osteocit-DTabletOralSeaford Pharmaceuticals Inc2003-02-132006-11-16Canada
OsteoligoCapsuleOralClinique Lafontaine Inc, Division Les Importations Ortho1998-01-221999-08-10Canada
Oyster Shell Calcium with Vitamin DTablet, film coatedOralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2005-11-15Not applicableUs
Phytofortis + Calcium A-DLiquid; TabletOralPhyto Health Corporation1983-12-312003-11-27Canada
PMS-risedronate Plus CalciumTabletOralPharmascience IncNot applicableNot applicableCanada
Pnv-dhaCapsule, gelatin coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Port A Mins Super Cal-mag 300/150 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Cal-mag 600/300TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Calcium 375 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Calcium 750 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Pour Ma SantéTabletOralProdemdis Enr.Not applicableNot applicableCanada
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
PremelTabletOralLe Naturiste J.M.B. Inc.2002-10-312008-07-31Canada
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenavite Forte TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
Prenavite TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
Prevencal + D A Croquer 600mgTabletOralLaboratoire Lalco Inc.1987-12-311998-08-14Canada
Prevencal 300 + D A CroquerTabletOralLaboratoire Lalco Inc.1987-12-311997-07-31Canada
Prevencal 500 +dTabletOralLaboratoire Lalco Inc.1987-12-311997-07-31Canada
Prevencal 600 + D Et FerTabletOralLaboratoire Lalco Inc.1987-12-311997-07-31Canada
Prevencal 600 + D Et MagnesiumTabletOralLaboratoire Lalco Inc.1987-12-311997-07-31Canada
Pure Calcium calciumTablet, chewableOralSaimdang Cosmetics Co., Ltd2010-08-24Not applicableUs
Redoxon-calTablet, effervescentOralBayer Inc Consumer Care1992-12-312007-08-02Canada
ReebokLiquidOralClearly Canadian Beverage Corporation2003-05-152009-08-06Canada
Revitex Ampoules Et ComprimesLiquid; TabletOralLes Produits Gerbex Inc.1988-12-312005-06-29Canada
Revival 1 TabTabletOralBio Vita1991-12-311999-08-12Canada
Rolaids Extra Strength Multi-symptom TabletsTabletOralSanofi Consumer Health Inc Sanofi Sante Grand Public Inc2004-09-012015-07-24Canada
Rolaids Extra Strength TabTabletOralWarner Lambert Canada Inc.1988-12-312000-08-25Canada
Silica-calcium With Biotin CapsulesCapsuleOralNaka Sales Ltd.2002-05-152009-07-29Canada
Somarexin and C 1000Liquid; TabletOralLaboratoire Lalco Inc.1977-12-312008-07-29Canada
Spd TabTabletOralSeroyal International Inc.1988-12-311996-09-10Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stom #2CapsuleOralMorinda Canada1999-12-202001-07-23Canada
Super C Crystals W CalciumPowderOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Super C-M-KTabletOralCreative Nutrition Canada Corp.1986-12-312007-07-11Canada
Super Cal Mag PlusTabletOralShaklee Corporation2002-07-022006-11-13Canada
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Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Supplement De Vitamines Et MinerauxLiquidOralLand Art Inc.1998-01-201999-08-02Canada
Supplements De Vitamines Et MinerauxLiquidOralLand Art Inc.1999-08-022008-06-26Canada
Swical D-M - TabTabletOralLes Laboratoires Swisse Inc.1996-12-312009-08-05Canada
Swical-multiTabletOralLes Laboratoires Swisse Inc.1997-05-282009-08-05Canada
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Tianshi Calcium and Vitamin D Chewable Tablets (melon Flavour)TabletOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Calcium and Vitamin D Chewable Tablets (peach Flavour)TabletOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Calcium and Vitamin D Chewable Tablets (strawberry Flavour)TabletOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Calcium With Natural Source Vitamin D TabletsTabletOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Calcium With Natural Source Vitamin E Softgel CapsulesCapsuleOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Vital Powder IPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Vital Powder IIPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Vital Powder IIIPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
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Vitafol OB CapletTabletOralExeltis Usa, Inc.2002-12-02Not applicableUs
Vitalife - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-11-132002-08-06Canada
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Vitamines A - D CalciumTabletOralLaboratoire Lalco Inc.Not applicableNot applicableCanada
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Categories
UNIISY7Q814VUP
CAS number7440-70-2
WeightAverage: 40.078
Monoisotopic: 39.962591155
Chemical FormulaCa
InChI KeyOYPRJOBELJOOCE-UHFFFAOYSA-N
InChI
InChI=1S/Ca
IUPAC Name
calcium
SMILES
[Ca]
Pharmacology
Indication

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.

Structured Indications Not Available
Pharmacodynamics

Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

Mechanism of action

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.

TargetKindPharmacological actionActionsOrganismUniProt ID
Voltage-dependent L-type calcium channel subunit alpha-1CProteinyes
ligand
HumanQ13936 details
Calcium-transporting ATPase type 2C member 1Proteinyes
agonist
HumanP98194 details
Troponin C, skeletal muscleProteinyes
agonist
HumanP02585 details
Troponin C, slow skeletal and cardiac musclesProteinyes
agonist
HumanP63316 details
Spectrin beta chain, non-erythrocytic 1Proteinunknown
agonist
HumanQ01082 details
Protein S100-BProteinunknownNot AvailableHumanP04271 details
CalpastatinProteinunknownNot AvailableHumanP20810 details
Cartilage oligomeric matrix proteinProteinunknownNot AvailableHumanP49747 details
CalmodulinProteinunknownNot AvailableHumanP0DP23 details
Amiloride-sensitive amine oxidase [copper-containing]ProteinunknownNot AvailableHumanP19801 details
Protein S100-A13ProteinunknownNot AvailableHumanQ99584 details
Alkaline phosphatase, placental typeProteinunknownNot AvailableHumanP05187 details
Protein S100-A8ProteinunknownNot AvailableHumanP05109 details
Protein S100-A9ProteinunknownNot AvailableHumanP06702 details
Protein S100-A2ProteinunknownNot AvailableHumanP29034 details
CeruloplasminProteinunknownNot AvailableHumanP00450 details
Bone morphogenetic protein 4ProteinunknownNot AvailableHumanP12644 details
Matrix Gla proteinProteinunknownNot AvailableHumanP08493 details
Protocadherin-19ProteinunknownNot AvailableHumanQ8TAB3 details
Programmed cell death protein 6ProteinunknownNot AvailableHumanO75340 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of elimination

The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.

Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Beta-Alanine MetabolismMetabolicSMP00007
Phospholipid BiosynthesisMetabolicSMP00025
Pantothenate and CoA BiosynthesisMetabolicSMP00027
Riboflavin MetabolismMetabolicSMP00070
Arachidonic Acid MetabolismMetabolicSMP00075
Meloxicam Action PathwayDrug actionSMP00106
Mefenamic Acid Action PathwayDrug actionSMP00109
Malate-Aspartate ShuttleMetabolicSMP00129
Dicumarol Action PathwayDrug actionSMP00270
Ardeparin Action PathwayDrug actionSMP00275
Streptokinase Action PathwayDrug actionSMP00282
Acebutolol Action PathwayDrug actionSMP00296
Atenolol Action PathwayDrug actionSMP00298
Nadolol Action PathwayDrug actionSMP00303
Oxprenolol Action PathwayDrug actionSMP00304
Pindolol Action PathwayDrug actionSMP00306
Gaucher DiseaseDiseaseSMP00349
17-Beta Hydroxysteroid Dehydrogenase III DeficiencyDiseaseSMP00356
Fc Epsilon Receptor I Signaling in Mast CellsSignalingSMP00358
Gout or Kelley-Seegmiller SyndromeDiseaseSMP00365
Carvedilol Action PathwayDrug actionSMP00367
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)DiseaseSMP00369
Tyrosinemia Type 3 (TYRO3)DiseaseSMP00370
Isradipine Action PathwayDrug actionSMP00378
Prilocaine Action PathwayDrug actionSMP00401
Heroin Action PathwayDrug actionSMP00407
Methadone Action PathwayDrug actionSMP00408
Alfentanil Action PathwayDrug actionSMP00413
Carfentanil Action PathwayDrug actionSMP00414
Azathioprine Action PathwayDrug actionSMP00427
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinCalcium may increase the arrhythmogenic activities of Acetyldigitoxin.Approved
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium.Approved
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium is combined with Alfacalcidol.Approved, Nutraceutical
AmlodipineThe therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium.Approved
AmrinoneThe therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium.Approved
AzelnidipineThe therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium.Approved
AzimilideThe therapeutic efficacy of Azimilide can be decreased when used in combination with Calcium.Investigational
BarnidipineThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium.Approved
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
BenidipineThe therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium.Approved
BepridilThe therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium.Approved, Withdrawn
CalcidiolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcidiol.Approved, Nutraceutical
CalcipotriolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcipotriol.Approved
CalcitriolThe risk or severity of adverse effects can be increased when Calcium is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe risk or severity of adverse effects can be increased when Calcium is combined with Calcium Acetate.Approved
CarboxyamidotriazoleThe therapeutic efficacy of Cai can be decreased when used in combination with Calcium.Investigational
CeftriaxoneThe risk or severity of adverse effects can be increased when Calcium is combined with Ceftriaxone.Approved
ChlorothiazideChlorothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
ChlortetracyclineThe serum concentration of Chlortetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
ChlorthalidoneChlorthalidone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
CholecalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Cholecalciferol.Approved, Nutraceutical
CilnidipineThe therapeutic efficacy of Cilnidipine can be decreased when used in combination with Calcium.Approved
CinnarizineThe therapeutic efficacy of Cinnarizine can be decreased when used in combination with Calcium.Approved
CinoxacinCalcium can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
CiprofloxacinCalcium can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
ClevidipineThe therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium.Approved
Clodronic AcidThe serum concentration of Clodronate can be decreased when it is combined with Calcium.Approved, Investigational, Vet Approved
DarodipineThe therapeutic efficacy of Darodipine can be decreased when used in combination with Calcium.Experimental
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Calcium.Approved
DemeclocyclineThe serum concentration of Demeclocycline can be decreased when it is combined with Calcium.Approved
DeslanosideCalcium may increase the arrhythmogenic activities of Deslanoside.Approved
DigitoxinCalcium may increase the arrhythmogenic activities of Digitoxin.Approved
DigoxinCalcium may increase the arrhythmogenic activities of Digoxin.Approved
DihydrotachysterolThe risk or severity of adverse effects can be increased when Calcium is combined with Dihydrotachysterol.Approved
DiltiazemThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium.Approved
Dipotassium phosphateCalcium can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DobutamineThe therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Calcium.Approved
DotarizineThe therapeutic efficacy of Dotarizine can be decreased when used in combination with Calcium.Investigational
DoxercalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Doxercalciferol.Approved
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Calcium.Approved, Investigational, Vet Approved
EfonidipineThe therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium.Approved
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Calcium.Approved
EnoxacinCalcium can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
EperisoneThe therapeutic efficacy of Eperisone can be decreased when used in combination with Calcium.Approved, Investigational
ErgocalciferolThe risk or severity of adverse effects can be increased when Calcium is combined with Ergocalciferol.Approved, Nutraceutical
EstramustineCalcium can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Calcium.Approved
FelodipineThe therapeutic efficacy of Felodipine can be decreased when used in combination with Calcium.Approved, Investigational
FendilineThe therapeutic efficacy of Fendiline can be decreased when used in combination with Calcium.Withdrawn
FleroxacinCalcium can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FlumequineCalcium can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be decreased when used in combination with Calcium.Approved
GabapentinThe therapeutic efficacy of Gabapentin can be decreased when used in combination with Calcium.Approved, Investigational
GallopamilThe therapeutic efficacy of Gallopamil can be decreased when used in combination with Calcium.Investigational
GarenoxacinCalcium can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
GatifloxacinCalcium can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GemifloxacinCalcium can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GrepafloxacinCalcium can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
HydrochlorothiazideHydrochlorothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Calcium.Approved, Investigational
IndapamideIndapamide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
IsradipineThe therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium.Approved
LacidipineThe therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium.Approved
LamotrigineThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium.Approved, Investigational
LercanidipineThe therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium.Approved, Investigational
LevofloxacinCalcium can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium.Approved
Lipoic AcidCalcium can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Nutraceutical
LomefloxacinCalcium can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium SulfateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium.Approved, Vet Approved
ManidipineThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium.Approved
MethyclothiazideMethyclothiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
MetolazoneMetolazone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
MibefradilThe therapeutic efficacy of Mibefradil can be decreased when used in combination with Calcium.Withdrawn
MinocyclineThe serum concentration of Minocycline can be decreased when it is combined with Calcium.Approved, Investigational
MoxifloxacinCalcium can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
NaftopidilThe therapeutic efficacy of Naftopidil can be decreased when used in combination with Calcium.Investigational
Nalidixic AcidCalcium can cause a decrease in the absorption of Nalidixic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NemonoxacinCalcium can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
NicardipineThe therapeutic efficacy of Nicardipine can be decreased when used in combination with Calcium.Approved
NifedipineThe therapeutic efficacy of Nifedipine can be decreased when used in combination with Calcium.Approved
NiguldipineThe therapeutic efficacy of Niguldipine can be decreased when used in combination with Calcium.Experimental
NiludipineThe therapeutic efficacy of Niludipine can be decreased when used in combination with Calcium.Experimental
NilvadipineThe therapeutic efficacy of Nilvadipine can be decreased when used in combination with Calcium.Approved
NimesulideThe therapeutic efficacy of Nimesulide can be decreased when used in combination with Calcium.Approved, Withdrawn
NimodipineThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium.Approved
NisoldipineThe therapeutic efficacy of Nisoldipine can be decreased when used in combination with Calcium.Approved
NitrendipineThe therapeutic efficacy of Nitrendipine can be decreased when used in combination with Calcium.Approved
NorfloxacinCalcium can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OfloxacinCalcium can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OleandrinCalcium may increase the arrhythmogenic activities of Anvirzel.Experimental
OuabainCalcium may increase the arrhythmogenic activities of Ouabain.Approved
OxytetracyclineThe serum concentration of Oxytetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Calcium.Approved
ParicalcitolThe risk or severity of adverse effects can be increased when Calcium is combined with Paricalcitol.Approved, Investigational
PazufloxacinCalcium can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
PefloxacinCalcium can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PerhexilineThe therapeutic efficacy of Perhexiline can be decreased when used in combination with Calcium.Approved
PinaveriumThe therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium.Approved
PolythiazidePolythiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
PregabalinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium.Approved, Illicit, Investigational
PrenylamineThe therapeutic efficacy of Prenylamine can be decreased when used in combination with Calcium.Withdrawn
PrulifloxacinCalcium can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
QuinethazoneQuinethazone may decrease the excretion rate of Calcium which could result in a higher serum level.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Calcium.Approved, Investigational
RosoxacinCalcium can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium glycerophosphateCalcium can cause a decrease in the absorption of Sodium glycerophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium phosphateCalcium can cause a decrease in the absorption of Sodium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SparfloxacinCalcium can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Strontium ranelateThe serum concentration of Strontium ranelate can be decreased when it is combined with Calcium.Approved
Technetium Tc-99m etidronateThe serum concentration of Technetium tc 99m etidronate can be decreased when it is combined with Calcium.Approved
Technetium Tc-99m medronateThe serum concentration of Technetium Tc-99m Medronate can be decreased when it is combined with Calcium.Approved
TemafloxacinCalcium can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Calcium.Approved, Vet Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Calcium.Approved
Tiludronic acidThe serum concentration of Tiludronate can be decreased when it is combined with Calcium.Approved, Vet Approved
Tolfenamic AcidThe therapeutic efficacy of Tolfenamic Acid can be decreased when used in combination with Calcium.Approved
TranilastThe therapeutic efficacy of Tranilast can be decreased when used in combination with Calcium.Approved, Investigational
TrichlormethiazideTrichlormethiazide may decrease the excretion rate of Calcium which could result in a higher serum level.Approved, Vet Approved
TriethylenetetramineThe serum concentration of Triethylenetetramine can be decreased when it is combined with Calcium.Approved
TrovafloxacinCalcium can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
VerapamilThe therapeutic efficacy of Verapamil can be decreased when used in combination with Calcium.Approved
VinpocetineThe therapeutic efficacy of Vinpocetine can be decreased when used in combination with Calcium.Investigational
XylometazolineThe therapeutic efficacy of Xylometazoline can be decreased when used in combination with Calcium.Approved
ZiconotideThe therapeutic efficacy of Ziconotide can be decreased when used in combination with Calcium.Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Calcium.Approved
Food InteractionsNot Available
References
Synthesis ReferenceUS5667761
General References
  1. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6. [PubMed:9278463 ]
  2. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003548. [PubMed:16034903 ]
  3. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D: Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. [PubMed:16481635 ]
  4. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005 May 7-13;365(9471):1621-8. [PubMed:15885294 ]
  5. Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005 Apr 30;330(7498):1003. [PubMed:15860827 ]
External Links
ATC CodesA11GB01 — Ascorbic acid (vit c) and calciumM05BB08 — Zoledronic acid, calcium and colecalciferol, sequentialM05BB02 — Risedronic acid and calcium, sequentialM05BB04 — Risedronic acid, calcium and colecalciferol, sequentialA11AA02 — Multivitamins and calciumM05BB01 — Etidronic acid and calcium, sequentialM05BB05 — Alendronic acid, calcium and colecalciferol, sequential
AHFS Codes
  • 34:00.00
  • 40:12.00
  • 40:18.17
  • 40:18.19
  • 40:34.00*
  • 56:04.00
  • 56:12.00
  • 88:08.00
  • 88:12.00
  • 88:29.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (25.6 KB)
MSDSDownload (47.9 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceChronic Kidney Disease (CKD) / Healthy Volunteers / Test Ferric Hydroxide Adipate as Phosphate Binder in Healthy Subjects1
0RecruitingPreventionBone destruction1
1CompletedNot AvailableHealthy Volunteers1
1CompletedPreventionAdenocarcinomas / Colorectal Adenomas / Colorectal Polyps1
1CompletedPreventionPaclitaxel-induced Neuropathy1
1CompletedTreatmentCalcium Deficiency / Deficiency, Vitamin D1
1CompletedTreatmentDiabetic Nephropathies1
1CompletedTreatmentHypertensive1
1CompletedTreatmentIron-refractory, Iron-deficiency Anemia (IRIDA)1
1RecruitingPreventionMalignant Neoplasm of Colon1
1RecruitingTreatmentHead Neck Cancer1
1, 2CompletedBasic ScienceOpioid Induced Motor Disturbances1
2CompletedPreventionCardiovascular Disease (CVD) / Heart Diseases / Hypertensive / Pregnancy Toxemias / Prophylaxis of preeclampsia / Vascular Diseases1
2CompletedPreventionDietary Carcinogenesis1
2CompletedPreventionBone destruction1
2CompletedTreatmentAutism Spectrum Disorder (ASD) / Sleeplessness1
2CompletedTreatmentHyperparathyroidism, Secondary / Renal Osteodystrophy1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentBone destruction1
2CompletedTreatmentParathyroid deficiency1
2RecruitingPreventionBone destruction / Osteopenia1
2RecruitingTreatmentBone Metabolism / Hyperparathyroidism, Primary1
2RecruitingTreatmentIron Deficiency Anemia (IDA) / Restless Legs Syndrome (RLS)1
2RecruitingTreatmentIron-Deficiency Anemias1
2RecruitingTreatmentBone destruction / Rheumatoid Arthritis1
2TerminatedTreatmentHypocalcemia1
2Unknown StatusBasic ScienceMetastatic Colorectal Cancers1
2Unknown StatusPreventionLead Toxicity1
2Unknown StatusTreatmentAdenocarincoma of Pancreas / Stage III Pancreatic Cancer / Stage IVA Pancreatic Cancer / Stage IVB Pancreatic Cancer1
2WithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Iron Deficiency Anemia (IDA)1
2, 3Active Not RecruitingPreventionAdenoma benign / Colorectal Cancers / Polyps1
2, 3CompletedTreatmentHeart Failure, Systolic / Iron-Deficiency Anemias1
2, 3CompletedTreatmentMale Infertility1
2, 3RecruitingPreventionNeoplasms, Colorectal1
2, 3TerminatedTreatmentIron-Deficiency Anemias / Postpartum Depression / Puerperal Disorders1
3Active Not RecruitingTreatmentHemodialysis-dependent patients / Hyperphosphataemia1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedPreventionBone destruction / Bone Diseases / Cardiovascular Disease (CVD) / Colonic Neoplasms / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia / Neoplasms, Breast / One to five years postmenopausal1
3CompletedPreventionCardiovascular Disease (CVD) / Eclampsia / Heart Diseases / HELLP Syndrome / Hypertensive / Pregnancy Toxemias / Prophylaxis of preeclampsia / Vascular Diseases1
3CompletedPreventionIron Deficiency1
3CompletedPreventionOvarian Hyperstimulation Syndrome1
3CompletedPreventionBone destruction1
3CompletedTreatmentAnemias4
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentChronic Kidney Disease (CKD) / Peritoneal dialysis therapy1
3CompletedTreatmentHyperphosphataemia / Renal Failure1
3CompletedTreatmentIron Deficiency Anemia (IDA)1
3CompletedTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentNeoplasms, Colorectal1
3CompletedTreatmentPaget's Disease of Bone1
3CompletedTreatmentPostpartum Anemia1
3CompletedTreatmentBone destruction2
3Not Yet RecruitingTreatmentHyperphosphataemia1
3Not Yet RecruitingTreatmentLiver Cirrhosis3
3RecruitingTreatmentHyperphosphataemia1
3RecruitingTreatmentLiver Cirrhosis / Muscle Cramps1
3TerminatedPreventionDiarrhea1
3TerminatedTreatmentIron Deficiency Anemia (IDA) / Nondialysis Dependent Chronic Kidney Disease1
3Unknown StatusTreatmentChronic Kidney Disease (CKD)1
4Active Not RecruitingTreatmentIron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass1
4CompletedPreventionBone destruction / Bone Loss / Epilepsies / Fracture Bone1
4CompletedPreventionWe Investigated the Relationship Between Plasma FGF23 Levels and Endothelial Dysfunction in a Sizable Series of Incident Stage 3-4 CKD Patients1
4CompletedTreatmentArteriosclerosis / Calcinosis / Hyperparathyroidism, Secondary1
4CompletedTreatmentBMI >27 kg/m2 / BMI >30 kg/m21
4CompletedTreatmentCardiovascular Events / Hemodialysis-dependent patients / Hyperphosphataemia1
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentIron-Deficiency Anemias / Kidney Failure,Chronic2
4CompletedTreatmentNutritional Rickets1
4CompletedTreatmentPostmenopausal Osteoporosis (PMO)2
4CompletedTreatmentPregnancy1
4CompletedTreatmentStage 3 Chronic Kidney Disease1
4CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
4Enrolling by InvitationTreatmentBone Diseases, Metabolic / Hyperphosphataemia / Renal Insufficiency,Chronic1
4TerminatedPreventionChronic Kidney Disease (CKD)1
4TerminatedTreatmentChronic Kidney Disease (CKD) / Iron-Deficiency Anemias1
4Unknown StatusTreatmentAnemias1
4Unknown StatusTreatmentIron Deficiency Anemia (IDA)1
4Unknown StatusTreatmentOther Nonspecific Abnormal Serum Enzyme Levels1
4WithdrawnTreatmentCrohn's Disease (CD)1
Not AvailableCompletedNot AvailableAnemias1
Not AvailableCompletedBasic ScienceIron Bioavailability1
Not AvailableCompletedPreventionChronic Kidney Disease (CKD)1
Not AvailableCompletedPreventionRenal Failure1
Not AvailableCompletedPreventionResidual Neuromuscular Blockade1
Not AvailableCompletedPreventionRisperidone-induced Hyperprolactinemia1
Not AvailableCompletedPreventionBone destruction1
Not AvailableCompletedTreatmentCardiovascular Mortality1
Not AvailableCompletedTreatmentCystic Fibrosis (CF) / Iron-Deficiency Anemias1
Not AvailableCompletedTreatmentEnd Stage Renal Disease (ESRD) / Hemodialysis-dependent patients / Intimal Media Thickness1
Not AvailableCompletedTreatmentHIV Seropositive1
Not AvailableCompletedTreatmentIntestinal Malabsorption / Pancreatitis, Chronic1
Not AvailableCompletedTreatmentPostpartum Hemorrhage1
Not AvailableCompletedTreatmentPremenstrual Syndrome1
Not AvailableRecruitingTreatmentAnemia in Pregnancy1
Not AvailableRecruitingTreatmentAnemias / Chronic Kidney Disease (CKD) / Iron Deficiency1
Not AvailableUnknown StatusPreventionPreEclampsia1
Not AvailableUnknown StatusTreatmentAnemias / Hemorrhage1
Not AvailableUnknown StatusTreatmentHaemodialyzed Patients / Hyperphosphataemia1
Not AvailableUnknown StatusTreatmentImpaired Renal Function1
Not AvailableWithdrawnPreventionAnemias1
Not AvailableWithdrawnTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Insulin Resistance / Insulin Sensitivity1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral.99 1/1
PowderOral
Granule, effervescent; kit; tabletOral
Capsule; liquidOral
TabletOral
PowderOral63.4 mg
PowderOral336 mg
TabletOral100 mg
TabletOral30 mg
WaferOral
CapsuleOral150 mg
TabletOral600 mg
TabletOral650 mg
CapsuleOral400 mg
TabletOral246 mg
CapsuleOral160.0 mg
TabletOral60 mg
TabletOral120 mg
CapsuleOral100 mg
TabletOral84.5 mg
TabletOral84 mg
LiquidOral100 mg
SyrupOral100 mg
SyrupOral110 mg
TabletOral150 mg
TabletOral125 mg
TabletOral266.7 mg
PowderOral216.7 mg
CapsuleOral500 mg
LiquidOral803.8 mg/1000mL
Powder, for solutionOral
TabletOral300 mg
CapsuleOral45 mg
TabletOral.99 1/1
TabletOral84.2 mg
TabletOral42.1 mg
LiquidIntravenous10 mg
LiquidOral
Liquid; tabletOral
Granule, effervescentOral
Capsule, gelatin coatedOral
CapsuleOral
Kit; tabletOral
TabletOral350 mg
TabletOral250 mg
Tablet, film coatedOral
Tablet, chewableOral
Tablet, effervescentOral
TabletOral200 mg
Tablet, extended releaseOral
SolutionOral1.458 mg
SolutionOral1.667 mg
TabletOral400 mg
LiquidOral400 mg
CapsuleOral600 mg
TabletOral500 mg
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)839°CMSDS
boiling point (°C)1484°CMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.0 mg/mLALOGPS
logP-1.3ALOGPS
logP-0.57ChemAxon
logS1.08ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as miscellaneous mixed metal/non-metals. These are inorganic compounds containing non-metal as well as metal atoms but not belonging to afore mentioned classes.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassMiscellaneous mixed metal/non-metals
Sub ClassNot Available
Direct ParentMiscellaneous mixed metal/non-metals
Alternative ParentsNot Available
SubstituentsMiscellaneous mixed metal/non-metal
Molecular FrameworkNot Available
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Uniprot Name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Molecular Weight:
248974.1 Da
References
  1. Boda D, Giri J, Henderson D, Eisenberg B, Gillespie D: Analyzing the components of the free-energy landscape in a calcium selective ion channel by Widom's particle insertion method. J Chem Phys. 2011 Feb 7;134(5):055102. doi: 10.1063/1.3532937. [PubMed:21303162 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Signal transducer activity
Specific Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Gene Name:
ATP2C1
Uniprot ID:
P98194
Uniprot Name:
Calcium-transporting ATPase type 2C member 1
Molecular Weight:
100576.42 Da
References
  1. Shi X, Chen M, Huvos PE, Hardwicke PM: Amino acid sequence of a Ca(2+)-transporting ATPase from the sarcoplasmic reticulum of the cross-striated part of the adductor muscle of the deep sea scallop: comparison to serca enzymes of other animals. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):359-74. [PubMed:9787799 ]
  2. Bonza MC, Martin H, Kang M, Lewis G, Greiner T, Giacometti S, Van Etten JL, De Michelis MI, Thiel G, Moroni A: A functional calcium-transporting ATPase encoded by chlorella viruses. J Gen Virol. 2010 Oct;91(Pt 10):2620-9. doi: 10.1099/vir.0.021873-0. Epub 2010 Jun 23. [PubMed:20573858 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Calcium ion binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC2
Uniprot ID:
P02585
Uniprot Name:
Troponin C, skeletal muscle
Molecular Weight:
18121.895 Da
References
  1. Martin SR, Avella G, Adrover M, de Nicola GF, Bullard B, Pastore A: Binding properties of the calcium-activated F2 isoform of Lethocerus troponin C. Biochemistry. 2011 Mar 22;50(11):1839-47. doi: 10.1021/bi102076s. Epub 2011 Feb 10. [PubMed:21250664 ]
  2. Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M: Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28. [PubMed:21035455 ]
  3. Robertson IM, Sun YB, Li MX, Sykes BD: A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. J Mol Cell Cardiol. 2010 Dec;49(6):1031-41. doi: 10.1016/j.yjmcc.2010.08.019. Epub 2010 Aug 27. [PubMed:20801130 ]
  4. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Troponin t binding
Specific Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Gene Name:
TNNC1
Uniprot ID:
P63316
Uniprot Name:
Troponin C, slow skeletal and cardiac muscles
Molecular Weight:
18402.36 Da
References
  1. Dweck D, Reynaldo DP, Pinto JR, Potter JD: A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding. J Biol Chem. 2010 Jun 4;285(23):17371-9. doi: 10.1074/jbc.M109.064105. Epub 2010 Apr 6. [PubMed:20371872 ]
  2. Swindle N, Tikunova SB: Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C. Biochemistry. 2010 Jun 15;49(23):4813-20. doi: 10.1021/bi100400h. [PubMed:20459070 ]
  3. Parvatiyar MS, Pinto JR, Liang J, Potter JD: Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C. J Biol Chem. 2010 Sep 3;285(36):27785-97. doi: 10.1074/jbc.M110.112326. Epub 2010 Jun 21. [PubMed:20566645 ]
  4. Baylor SM, Hollingworth S: Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling. Prog Biophys Mol Biol. 2011 May;105(3):162-79. doi: 10.1016/j.pbiomolbio.2010.06.001. Epub 2010 Jun 25. [PubMed:20599552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Structural constituent of cytoskeleton
Specific Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Gene Name:
SPTBN1
Uniprot ID:
Q01082
Uniprot Name:
Spectrin beta chain, non-erythrocytic 1
Molecular Weight:
274606.995 Da
References
  1. Wallis CJ, Wenegieme EF, Babitch JA: Characterization of calcium binding to brain spectrin. J Biol Chem. 1992 Mar 5;267(7):4333-7. [PubMed:1537825 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within...
Gene Name:
S100B
Uniprot ID:
P04271
Uniprot Name:
Protein S100-B
Molecular Weight:
10712.985 Da
References
  1. Lee TS, Mane S, Eid T, Zhao H, Lin A, Guan Z, Kim JH, Schweitzer J, King-Stevens D, Weber P, Spencer SS, Spencer DD, de Lanerolle NC: Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med. 2007 Jan-Feb;13(1-2):1-13. [PubMed:17515952 ]
  2. Marlatt NM, Shaw GS: Amide exchange shows calcium-induced conformational changes are transmitted to the dimer interface of S100B. Biochemistry. 2007 Jun 26;46(25):7478-87. Epub 2007 May 31. [PubMed:17536784 ]
  3. Liang J, Luo G, Ning X, Shi Y, Zhai H, Sun S, Jin H, Liu Z, Zhang F, Lu Y, Zhao Y, Chen X, Zhang H, Guo X, Wu K, Fan D: Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein. Biochem Cell Biol. 2007 Jun;85(3):375-83. [PubMed:17612632 ]
  4. Friel LA, Romero R, Edwin S, Nien JK, Gomez R, Chaiworapongsa T, Kusanovic JP, Tolosa JE, Hassan SS, Espinoza J: The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35(5):385-93. [PubMed:17624933 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Poly(a) rna binding
Specific Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Gene Name:
CAST
Uniprot ID:
P20810
Uniprot Name:
Calpastatin
Molecular Weight:
76572.035 Da
References
  1. Hanna RA, Garcia-Diaz BE, Davies PL: Calpastatin simultaneously binds four calpains with different kinetic constants. FEBS Lett. 2007 Jun 26;581(16):2894-8. Epub 2007 May 25. [PubMed:17543955 ]
  2. De Tullio R, Averna M, Stifanese R, Parr T, Bardsley RG, Pontremoli S, Melloni E: Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons. Arch Biochem Biophys. 2007 Sep 1;465(1):148-56. Epub 2007 May 30. [PubMed:17570336 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both pr...
Gene Name:
COMP
Uniprot ID:
P49747
Uniprot Name:
Cartilage oligomeric matrix protein
Molecular Weight:
82859.88 Da
References
  1. Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 2007 Aug 24;282(34):24591-8. Epub 2007 Jun 22. [PubMed:17588949 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Titin binding
Specific Function:
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Gene Name:
CALM1
Uniprot ID:
P0DP23
Uniprot Name:
Calmodulin
Molecular Weight:
16837.47 Da
References
  1. Sosa V, Carbo R, Guarner V: Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia. Eur J Pharmacol. 2007 Jul 30;568(1-3):83-8. Epub 2007 Apr 30. [PubMed:17537429 ]
  2. Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y: The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem. 2007 Aug 10;282(32):23737-44. Epub 2007 Jun 5. [PubMed:17550897 ]
  3. Schallreuter KU, Gibbons NC, Zothner C, Abou Elloof MM, Wood JM: Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun. 2007 Aug 17;360(1):70-5. Epub 2007 Jun 11. [PubMed:17592724 ]
  4. Caride AJ, Filoteo AG, Penniston JT, Strehler EE: The plasma membrane Ca2+ pump isoform 4a differs from isoform 4b in the mechanism of calmodulin binding and activation kinetics: implications for Ca2+ signaling. J Biol Chem. 2007 Aug 31;282(35):25640-8. Epub 2007 Jun 26. [PubMed:17595168 ]
  5. Lo LW, Chen YC, Chen YJ, Wongcharoen W, Lin CI, Chen SA: Calmodulin kinase II inhibition prevents arrhythmic activity induced by alpha and beta adrenergic agonists in rabbit pulmonary veins. Eur J Pharmacol. 2007 Oct 1;571(2-3):197-208. Epub 2007 Jun 13. [PubMed:17612522 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Gene Name:
AOC1
Uniprot ID:
P19801
Uniprot Name:
Amiloride-sensitive amine oxidase [copper-containing]
Molecular Weight:
85377.1 Da
References
  1. Elmore BO, Bollinger JA, Dooley DM: Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79. Epub 2002 Feb 13. [PubMed:12072962 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not ...
Gene Name:
S100A13
Uniprot ID:
Q99584
Uniprot Name:
Protein S100-A13
Molecular Weight:
11471.095 Da
References
  1. Sivaraja V, Kumar TK, Rajalingam D, Graziani I, Prudovsky I, Yu C: Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006 Sep 1;91(5):1832-43. Epub 2006 Jun 9. [PubMed:16766622 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Not Available
Gene Name:
ALPP
Uniprot ID:
P05187
Uniprot Name:
Alkaline phosphatase, placental type
Molecular Weight:
57953.31 Da
References
  1. Llinas P, Masella M, Stigbrand T, Menez A, Stura EA, Le Du MH: Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones. Protein Sci. 2006 Jul;15(7):1691-700. [PubMed:16815919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
Specific Function:
Arachidonic acid binding
Gene Name:
S100A8
Uniprot ID:
P05109
Uniprot Name:
Protein S100-A8
Molecular Weight:
10834.43 Da
References
  1. Vogl T, Leukert N, Barczyk K, Strupat K, Roth J: Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochim Biophys Acta. 2006 Nov;1763(11):1298-306. Epub 2006 Aug 25. [PubMed:17050004 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.
Specific Function:
Antioxidant activity
Gene Name:
S100A9
Uniprot ID:
P06702
Uniprot Name:
Protein S100-A9
Molecular Weight:
13241.955 Da
References
  1. Vogl T, Leukert N, Barczyk K, Strupat K, Roth J: Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochim Biophys Acta. 2006 Nov;1763(11):1298-306. Epub 2006 Aug 25. [PubMed:17050004 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
Gene Name:
S100A2
Uniprot ID:
P29034
Uniprot Name:
Protein S100-A2
Molecular Weight:
11116.695 Da
References
  1. Koch M, Bhattacharya S, Kehl T, Gimona M, Vasak M, Chazin W, Heizmann CW, Kroneck PM, Fritz G: Implications on zinc binding to S100A2. Biochim Biophys Acta. 2007 Mar;1773(3):457-70. Epub 2006 Dec 19. [PubMed:17239974 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ferroxidase activity
Specific Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pul...
Gene Name:
CP
Uniprot ID:
P00450
Uniprot Name:
Ceruloplasmin
Molecular Weight:
122204.45 Da
References
  1. Bento I, Peixoto C, Zaitsev VN, Lindley PF: Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites. Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):240-8. Epub 2007 Jan 16. [PubMed:17242517 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
Specific Function:
Bmp receptor binding
Gene Name:
BMP4
Uniprot ID:
P12644
Uniprot Name:
Bone morphogenetic protein 4
Molecular Weight:
46554.545 Da
References
  1. Yao Y, Shahbazian A, Bostrom KI: Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. Circ Res. 2008 May 9;102(9):1065-74. doi: 10.1161/CIRCRESAHA.107.166124. Epub 2008 Mar 27. [PubMed:18369157 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Structural constituent of bone
Specific Function:
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Gene Name:
MGP
Uniprot ID:
P08493
Uniprot Name:
Matrix Gla protein
Molecular Weight:
12353.06 Da
References
  1. Yao Y, Shahbazian A, Bostrom KI: Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. Circ Res. 2008 May 9;102(9):1065-74. doi: 10.1161/CIRCRESAHA.107.166124. Epub 2008 Mar 27. [PubMed:18369157 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Calcium ion binding
Specific Function:
Potential calcium-dependent cell-adhesion protein.
Gene Name:
PCDH19
Uniprot ID:
Q8TAB3
Uniprot Name:
Protocadherin-19
Molecular Weight:
126251.425 Da
References
  1. Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, Barthorpe S, Buck G, Cole J, Halliday K, Jones D, Lee R, Madison M, Mironenko T, Varian J, West S, Widaa S, Wray P, Teague J, Dicks E, Butler A, Menzies A, Jenkinson A, Shepherd R, Gusella JF, Afawi Z, Mazarib A, Neufeld MY, Kivity S, Lev D, Lerman-Sagie T, Korczyn AD, Derry CP, Sutherland GR, Friend K, Shaw M, Corbett M, Kim HG, Geschwind DH, Thomas P, Haan E, Ryan S, McKee S, Berkovic SF, Futreal PA, Stratton MR, Mulley JC, Gecz J: X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet. 2008 Jun;40(6):776-81. doi: 10.1038/ng.149. Epub 2008 May 11. [PubMed:18469813 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein dimerization activity
Specific Function:
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogene...
Gene Name:
PDCD6
Uniprot ID:
O75340
Uniprot Name:
Programmed cell death protein 6
Molecular Weight:
21868.32 Da
References
  1. Suzuki H, Kawasaki M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M: Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):974-7. doi: 10.1107/S1744309108030297. Epub 2008 Oct 31. [PubMed:18997320 ]
Drug created on July 06, 2007 14:28 / Updated on September 01, 2017 10:39