Identification

Name
Carvedilol
Accession Number
DB01136  (APRD00091)
Type
Small Molecule
Groups
Approved, Investigational
Description

Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.

Structure
Thumb
Synonyms
  • (+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol
  • Carvedilol
  • Carvedilolum
  • SKF 105517
Product Ingredients
IngredientUNIICASInChI Key
Carvedilol phosphateEQT531S367610309-89-2LHNYXTULDSJZRB-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CarvedilolTablet3.125 mgOralMeliapharm Inc2010-06-012014-06-25Canada
CarvedilolTablet25.0 mgOralPro Doc Limitee2009-06-12Not applicableCanada
CarvedilolTablet25 mgOralSivem Pharmaceuticals Ulc2004-04-06Not applicableCanada
CarvedilolTablet3.125 mgOralSivem Pharmaceuticals Ulc2004-04-06Not applicableCanada
CarvedilolTablet3.125 mgOralPro Doc Limitee2009-06-12Not applicableCanada
CarvedilolTablet12.5 mgOralMeliapharm Inc2010-05-172014-06-25Canada
CarvedilolTablet6.25 mgOralSanis Health Inc2011-06-10Not applicableCanada
CarvedilolTablet12.5 mgOralSivem Pharmaceuticals Ulc2004-04-06Not applicableCanada
CarvedilolTablet12.5 mgOralPro Doc Limitee2009-06-12Not applicableCanada
CarvedilolTablet25 mgOralSanis Health Inc2011-06-10Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-carvedilolTablet25 mgOralApotex Corporation2003-08-06Not applicableCanada
Apo-carvedilolTablet3.125 mgOralApotex Corporation2003-08-06Not applicableCanada
Apo-carvedilolTablet12.5 mgOralApotex Corporation2003-08-06Not applicableCanada
Apo-carvedilolTablet6.25 mgOralApotex Corporation2003-08-06Not applicableCanada
Auro-carvedilolTablet6.25 mgOralAuro Pharma Inc2014-02-06Not applicableCanada
Auro-carvedilolTablet25 mgOralAuro Pharma Inc2014-02-06Not applicableCanada
Auro-carvedilolTablet3.125 mgOralAuro Pharma Inc2014-02-06Not applicableCanada
Auro-carvedilolTablet12.5 mgOralAuro Pharma Inc2014-02-06Not applicableCanada
Ava-carvedilolTablet6.25 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-carvedilolTablet25 mgOralAvanstra Inc2011-10-112014-08-21Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Hypertenevide-12.5Carvedilol + L-ArginineKitPhysician Therapeutics Llc2011-07-072016-10-13Us
International/Other Brands
COREGCR
Categories
UNII
0K47UL67F2
CAS number
72956-09-3
Weight
Average: 406.4742
Monoisotopic: 406.18925733
Chemical Formula
C24H26N2O4
InChI Key
OGHNVEJMJSYVRP-UHFFFAOYSA-N
InChI
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
IUPAC Name
1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
SMILES
COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2

Pharmacology

Indication

For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Associated Conditions
Pharmacodynamics

Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin. Carvedilol is a racemic mixture in which nonselective b-adrenoreceptor blocking activity is present in the S(-) enantiomer and a-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity. The effect of carvedilol's b-adrenoreceptor blocking activity has been demonstrated in animal and human studies showing that carvedilol (1) reduces cardiac output in normal subjects; (2) reduces exercise-and/or isoproterenol-induced tachycardia and (3) reduces reflex orthostatic tachycardia.

Mechanism of action

Carvedilol is a racemic mixture in which nonselective beta-adrenoreceptor blocking activity is present in the S(-) enantiomer and alpha-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol's beta-adrenergic receptor blocking ability decreases the heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its alpha adrenergic receptor blocking properties. Carvedilol and its metabolite BM-910228 (a less potent beta blocker, but more potent antioxidant) have been shown to restore the inotropic responsiveness to Ca2+ in OH- free radical-treated myocardium. Carvedilol and its metabolites also prevent OH- radical-induced decrease in sarcoplasmic reticulum Ca2+-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in chronic heart failure by preventing free radical damage.

TargetActionsOrganism
ABeta-1 adrenergic receptor
antagonist
Human
AAlpha-1A adrenergic receptor
antagonist
Human
UNADH dehydrogenase [ubiquinone] 1 subunit C2
inhibitor
Human
UBeta-2 adrenergic receptor
antagonist
Human
UVascular endothelial growth factor A
other
Human
UNatriuretic peptides B
other
Human
UGap junction alpha-1 protein
other
Human
UPotassium voltage-gated channel subfamily H member 2
inhibitor
Human
UVascular cell adhesion protein 1
inhibitor
Human
UAlpha-1D adrenergic receptor
antagonist
Human
UAlpha-1B adrenergic receptor
antagonist
Human
UAlpha-2C adrenergic receptor
antagonist
Human
UAlpha-2B adrenergic receptor
antagonist
Human
UAlpha-2A adrenergic receptor
antagonist
Human
UE-selectin
inhibitor
Human
UHypoxia-inducible factor 1-alpha
modulator
Human
UInward rectifier potassium channel 4Not AvailableHuman
Absorption

Carvedilol is rapidly and extensively absorbed following oral administration, with an absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism.

Volume of distribution
  • 115 L
Protein binding

98%

Metabolism

Hepatic. Carvedilol is metabolized primarily by aromatic ring oxidation and glucuronidation. The oxidative metabolites are further metabolized by conjugation via glucuronidation and sulfation. Demethylation and hydroxylation at the phenol ring produce three active metabolites with b-receptor blocking activity. The 4'-hydroxyphenyl metabolite is approximately 13 times more potent than carvedilol for b-blockade.

Route of elimination

Carvedilol is extensively metabolized. Less than 2% of the dose was excreted unchanged in the urine. Carvedilol is metabolized primarily by aromatic ring oxidation and glucuronidation. The oxidative metabolites are further metabolized by conjugation via glucuronidation and sulfation. The metabolites of carvedilol are excreted primarily via the bile into the feces.

Half life

7-10 hours

Clearance
  • 500-700 mL/min
Toxicity

Not expected to be toxic following ingestion.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Carvedilol Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Beta-1 adrenergic receptor---(C;C) / (C;G) / (A;A)C Allele, homozygousEffect Directly StudiedPatients with this genotype in ADRB1 have an increased likelihood of responding to carvedilol for the treatment of increased blood pressure.Details
Cytochrome P450 2D6CYP2D6*3Not AvailableC alleleEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*4Not AvailableC alleleEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*5Not AvailableWhole-gene deletionEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*6Not Available1707delTEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*7Not Available2935A>CEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*8Not Available1758G>TEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*11Not Available883G>CEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*12Not Available124G>AEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*13Not AvailableCYP2D7/2D6 hybrid gene structureEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*14ANot Available1758G>AEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*15Not Available137insT, 137_138insTEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*19Not Available2539_2542delAACTEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*20Not Available1973_1974insGEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*21Not Available2573insCEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*31Not Available-1770G>A / -1584C>G  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*36Not Available100C>T / -1426C>T  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*38Not Available2587_2590delGACTEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*40Not Available1863_1864ins(TTT CGC CCC)2Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*42Not Available3259_3260insGTEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*44Not Available2950G>CEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*47Not Available100C>T / -1426C>T  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*51Not Available-1584C>G / -1235A>G  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*56Not Available3201C>TEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*57Not Available100C>T / 310G>T  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*62Not Available4044C>TEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*68ANot Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*68BNot AvailableSimilar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*69Not Available2988G>A / -1426C>T  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*92Not Available1995delCEffect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*100Not Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details
Cytochrome P450 2D6CYP2D6*101Not Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, increased dizziness.Details

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-Phenanthroline1,10-Phenanthroline may increase the bradycardic activities of Carvedilol.Experimental
4-MethoxyamphetamineThe therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.Experimental, Illicit
AbediterolThe therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.Investigational
AbemaciclibThe serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.Approved, Investigational
AbirateroneThe serum concentration of Carvedilol can be increased when it is combined with Abiraterone.Approved
AcebutololAcebutolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
AceclofenacAceclofenac may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
AcemetacinAcemetacin may decrease the antihypertensive activities of Carvedilol.Approved, Experimental, Investigational
AcepromazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.Approved, Vet Approved
AceprometazineThe serum concentration of Carvedilol can be increased when it is combined with Aceprometazine.Approved
AcetohexamideCarvedilol may increase the hypoglycemic activities of Acetohexamide.Approved, Investigational, Withdrawn
AcetophenazineThe serum concentration of Carvedilol can be increased when it is combined with Acetophenazine.Approved
AcetylcholineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Acetylcholine.Approved
AcetyldigitoxinCarvedilol may increase the bradycardic activities of Acetyldigitoxin.Approved
AcetyldigoxinCarvedilol may increase the bradycardic activities of Acetyldigoxin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
AdrafinilThe therapeutic efficacy of Adrafinil can be decreased when used in combination with Carvedilol.Withdrawn
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Carvedilol.Approved
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with Carvedilol.Experimental, Investigational
Agrostis gigantea pollenThe risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Carvedilol.Approved
Agrostis stolonifera pollenThe risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Carvedilol.Approved
AlaproclateThe serum concentration of Carvedilol can be increased when it is combined with Alaproclate.Experimental
AlclofenacAlclofenac may decrease the antihypertensive activities of Carvedilol.Approved, Withdrawn
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Carvedilol.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Carvedilol.Experimental, Investigational
AlfentanilAlfentanil may increase the bradycardic activities of Carvedilol.Approved, Illicit
AlimemazineThe serum concentration of Carvedilol can be increased when it is combined with Alimemazine.Approved, Vet Approved
AliskirenCarvedilol may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Carvedilol.Approved, Investigational
AlminoprofenAlminoprofen may decrease the antihypertensive activities of Carvedilol.Experimental
AlosetronThe metabolism of Carvedilol can be decreased when combined with Alosetron.Approved, Withdrawn
AlprenololAlprenolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Withdrawn
AmbenoniumAmbenonium may increase the bradycardic activities of Carvedilol.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Carvedilol.Approved, Investigational
AmibegronThe therapeutic efficacy of Amibegron can be decreased when used in combination with Carvedilol.Investigational
AmifostineCarvedilol may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Carvedilol.Approved
AminophenazoneAminophenazone may decrease the antihypertensive activities of Carvedilol.Approved, Withdrawn
AmiodaroneThe therapeutic efficacy of Carvedilol can be increased when used in combination with Amiodarone.Approved, Investigational
AmitrazThe therapeutic efficacy of Amitraz can be decreased when used in combination with Carvedilol.Vet Approved
AmitriptylineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.Approved
AmlodipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Amlodipine.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Carvedilol.Approved, Illicit
AmodiaquineThe risk or severity of QTc prolongation can be decreased when Amodiaquine is combined with Carvedilol.Approved, Investigational
AmoxapineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.Approved
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Carvedilol.Approved, Investigational
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Carvedilol.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Carvedilol is combined with Amyl Nitrite.Approved
AnisodamineThe therapeutic efficacy of Anisodamine can be decreased when used in combination with Carvedilol.Investigational
Anthoxanthum odoratum pollenThe risk of a hypersensitivity reaction to Anthoxanthum odoratum pollen is increased when it is combined with Carvedilol.Approved
AntipyrineAntipyrine may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
AntrafenineAntrafenine may decrease the antihypertensive activities of Carvedilol.Approved
ApalutamideThe serum concentration of Carvedilol can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Carvedilol.Approved
ApomorphineThe therapeutic efficacy of Apomorphine can be decreased when used in combination with Carvedilol.Approved, Investigational
ApraclonidineThe therapeutic efficacy of Apraclonidine can be decreased when used in combination with Carvedilol.Approved
AprepitantThe serum concentration of Carvedilol can be increased when it is combined with Aprepitant.Approved, Investigational
AranidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Aranidipine.Approved, Investigational
ArbutamineThe therapeutic efficacy of Arbutamine can be decreased when used in combination with Carvedilol.Approved
ArdeparinThe risk or severity of hyperkalemia can be increased when Ardeparin is combined with Carvedilol.Approved, Investigational, Withdrawn
ArecolineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Arecoline.Experimental
ArformoterolThe therapeutic efficacy of Arformoterol can be decreased when used in combination with Carvedilol.Approved, Investigational
ArotinololArotinolol may increase the orthostatic hypotensive activities of Carvedilol.Investigational
Arrhenatherum elatius pollenThe risk of a hypersensitivity reaction to Arrhenatherum elatius pollen is increased when it is combined with Carvedilol.Approved
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Carvedilol.Approved, Investigational
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Carvedilol.Approved, Nutraceutical
AsenapineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.Approved
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Carvedilol.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Carvedilol can be decreased when combined with Atazanavir.Approved, Investigational
AtenololAtenolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Carvedilol.Approved
AvanafilAvanafil may increase the antihypertensive activities of Carvedilol.Approved
AvatrombopagThe serum concentration of Avatrombopag can be increased when it is combined with Carvedilol.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Carvedilol.Approved, Investigational
AzapropazoneAzapropazone may decrease the antihypertensive activities of Carvedilol.Withdrawn
AzelnidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Azelnidipine.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Carvedilol is combined with Azilsartan medoxomil.Approved, Investigational
BalsalazideBalsalazide may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
BambuterolThe therapeutic efficacy of Bambuterol can be decreased when used in combination with Carvedilol.Approved, Investigational
BarbexacloneBarbexaclone may increase the hypotensive activities of Carvedilol.Experimental
BarbitalBarbital may increase the hypotensive activities of Carvedilol.Illicit
BaricitinibThe serum concentration of Baricitinib can be increased when it is combined with Carvedilol.Approved, Investigational
BarnidipineCarvedilol may increase the antihypertensive activities of Barnidipine.Approved
BefunololThe therapeutic efficacy of Befunolol can be decreased when used in combination with Carvedilol.Experimental
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Carvedilol.Approved, Investigational
BemiparinThe risk or severity of hyperkalemia can be increased when Bemiparin is combined with Carvedilol.Approved, Investigational
BenazeprilBenazepril may increase the hypotensive activities of Carvedilol.Approved, Investigational
BenazeprilatCarvedilol may increase the hypotensive activities of Benazeprilat.Experimental
BencyclaneThe risk or severity of hypotension can be increased when Carvedilol is combined with Bencyclane.Experimental
BendazacBendazac may decrease the antihypertensive activities of Carvedilol.Experimental
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Carvedilol.Approved
BenidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Benidipine.Approved, Investigational
BenmoxinBenmoxin may increase the hypotensive activities of Carvedilol.Withdrawn
BenorilateBenorilate may decrease the antihypertensive activities of Carvedilol.Experimental
BenoxaprofenBenoxaprofen may decrease the antihypertensive activities of Carvedilol.Withdrawn
BenzphetamineThe therapeutic efficacy of Benzphetamine can be decreased when used in combination with Carvedilol.Approved, Illicit
BenzydamineBenzydamine may decrease the antihypertensive activities of Carvedilol.Approved
BepridilThe risk or severity of hypotension can be increased when Carvedilol is combined with Bepridil.Approved, Withdrawn
BeractantCarvedilol may increase the bradycardic activities of Beractant.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Carvedilol.Approved, Vet Approved
BetaxololBetaxolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
BethanecholThe risk or severity of adverse effects can be increased when Carvedilol is combined with Bethanechol.Approved
BethanidineThe therapeutic efficacy of Bethanidine can be decreased when used in combination with Carvedilol.Approved
BevantololCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bevantolol.Approved
BicalutamideThe metabolism of Carvedilol can be decreased when combined with Bicalutamide.Approved
BietaserpineBietaserpine may increase the hypotensive activities of Carvedilol.Experimental
BimatoprostBimatoprost may increase the hypotensive activities of Carvedilol.Approved, Investigational
BioallethrinThe risk or severity of hypotension can be increased when Carvedilol is combined with Bioallethrin.Approved, Experimental
BisoprololBisoprolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
BitolterolThe therapeutic efficacy of Bitolterol can be decreased when used in combination with Carvedilol.Withdrawn
BL-1020The serum concentration of Carvedilol can be increased when it is combined with BL-1020.Investigational
BoceprevirThe metabolism of Carvedilol can be decreased when combined with Boceprevir.Approved, Withdrawn
BopindololBopindolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Carvedilol.Approved, Investigational
BosentanThe serum concentration of Carvedilol can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Carvedilol.Approved
Bouteloua gracilis pollenThe risk of a hypersensitivity reaction to Bouteloua gracilis pollen is increased when it is combined with Carvedilol.Approved
BQ-123Carvedilol may increase the hypotensive activities of BQ-123.Investigational
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Carvedilol.Approved, Investigational
BretyliumBretylium may increase the bradycardic activities of Carvedilol.Approved
BrexpiprazoleCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Brexpiprazole.Approved, Investigational
BrimonidineBrimonidine may increase the antihypertensive activities of Carvedilol.Approved
BromfenacBromfenac may decrease the antihypertensive activities of Carvedilol.Approved
BromocriptineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bromocriptine.Approved, Investigational
BromperidolThe serum concentration of Bromperidol can be increased when it is combined with Carvedilol.Approved, Investigational
Bromus secalinus pollenThe risk of a hypersensitivity reaction to Bromus secalinus pollen is increased when it is combined with Carvedilol.Approved
BucindololCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bucindolol.Investigational
BufexamacBufexamac may decrease the antihypertensive activities of Carvedilol.Approved, Experimental
BufuralolBufuralol may increase the orthostatic hypotensive activities of Carvedilol.Experimental, Investigational
BumadizoneBumadizone may decrease the antihypertensive activities of Carvedilol.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Carvedilol.Approved
BunazosinCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bunazosin.Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Carvedilol.Approved, Investigational
BupranololBupranolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
BupropionThe metabolism of Carvedilol can be decreased when combined with Bupropion.Approved
ButaperazineThe serum concentration of Carvedilol can be increased when it is combined with Butaperazine.Experimental
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Carvedilol.Approved
CabergolineCarvedilol may increase the vasoconstricting activities of Cabergoline.Approved
CadralazineCadralazine may increase the hypotensive activities of Carvedilol.Experimental
CaffeineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Caffeine.Approved
CalfactantCarvedilol may increase the bradycardic activities of Calfactant.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Carvedilol.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Carvedilol.Approved
CandesartanCarvedilol may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilCandesartan cilexetil may increase the hypotensive activities of Carvedilol.Approved
CandoxatrilCandoxatril may increase the hypotensive activities of Carvedilol.Experimental
CapecitabineThe serum concentration of Carvedilol can be increased when it is combined with Capecitabine.Approved, Investigational
CaptoprilCarvedilol may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe serum concentration of Carvedilol can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbamoylcholineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Carbamoylcholine.Approved
Carbaspirin calciumCarbaspirin calcium may decrease the antihypertensive activities of Carvedilol.Experimental, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Carvedilol.Approved, Investigational
CarboxyamidotriazoleThe risk or severity of hypotension can be increased when Carvedilol is combined with Carboxyamidotriazole.Investigational
CarbutamideCarvedilol may increase the hypoglycemic activities of Carbutamide.Experimental
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Carvedilol.Approved, Investigational
CaroverineThe risk or severity of hypotension can be increased when Carvedilol is combined with Caroverine.Experimental
CaroxazoneCaroxazone may increase the hypotensive activities of Carvedilol.Withdrawn
CarprofenCarprofen may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved, Withdrawn
CarteololCarteolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
CelecoxibCelecoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
CeliprololThe therapeutic efficacy of Celiprolol can be decreased when used in combination with Carvedilol.Approved, Investigational
CeritinibCarvedilol may increase the bradycardic activities of Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Carvedilol.Approved, Withdrawn
Cerliponase alfaThe serum concentration of Cerliponase alfa can be increased when it is combined with Carvedilol.Approved, Investigational
CertoparinThe risk or severity of hyperkalemia can be increased when Certoparin is combined with Carvedilol.Approved, Investigational
CevimelineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Cevimeline.Approved
ChlorambucilThe serum concentration of Chlorambucil can be increased when it is combined with Carvedilol.Approved
ChloroquineThe risk or severity of QTc prolongation can be decreased when Chloroquine is combined with Carvedilol.Approved, Investigational, Vet Approved
ChlorothiazideChlorothiazide may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
ChlorproethazineThe serum concentration of Carvedilol can be increased when it is combined with Chlorproethazine.Experimental
ChlorpromazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Chlorpromazine.Approved, Investigational, Vet Approved
ChlorpropamideCarvedilol may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Carvedilol.Approved
CholecalciferolThe metabolism of Carvedilol can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the antihypertensive activities of Carvedilol.Approved
CicletanineCarvedilol may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilCarvedilol may increase the hypotensive activities of Cilazapril.Approved
CilnidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Cilnidipine.Approved, Investigational
CimicoxibCimicoxib may decrease the antihypertensive activities of Carvedilol.Investigational
CinacalcetThe metabolism of Carvedilol can be decreased when combined with Cinacalcet.Approved
CinnarizineThe risk or severity of hypotension can be increased when Carvedilol is combined with Cinnarizine.Approved, Investigational
CiprofloxacinThe metabolism of Carvedilol can be decreased when combined with Ciprofloxacin.Approved, Investigational
CirazolineThe therapeutic efficacy of Cirazoline can be decreased when used in combination with Carvedilol.Experimental
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Carvedilol.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Carvedilol.Approved
ClarithromycinThe metabolism of Carvedilol can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Carvedilol can be decreased when combined with Clemastine.Approved, Investigational
ClenbuterolThe therapeutic efficacy of Clenbuterol can be decreased when used in combination with Carvedilol.Approved, Investigational, Vet Approved
ClevidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Clevidipine.Approved, Investigational
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Carvedilol.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Carvedilol.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Carvedilol.Approved, Investigational, Vet Approved
ClonidineThe therapeutic efficacy of Clonidine can be decreased when used in combination with Carvedilol.Approved
ClonixinClonixin may decrease the antihypertensive activities of Carvedilol.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Carvedilol.Approved
CloranololCloranolol may increase the orthostatic hypotensive activities of Carvedilol.Experimental
ClotrimazoleThe serum concentration of Carvedilol can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Clozapine.Approved
CobicistatThe serum concentration of Carvedilol can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Carvedilol.Approved, Investigational
CocaineThe metabolism of Carvedilol can be decreased when combined with Cocaine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Carvedilol.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Carvedilol.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Carvedilol.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Carvedilol.Approved, Investigational
CoumaphosCoumaphos may increase the bradycardic activities of Carvedilol.Vet Approved
CrisaboroleThe serum concentration of Carvedilol can be increased when it is combined with Crisaborole.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Carvedilol.Approved
CryptenamineCryptenamine may increase the hypotensive activities of Carvedilol.Approved
CurcuminThe serum concentration of Carvedilol can be increased when it is combined with Curcumin.Approved, Investigational
CyamemazineThe serum concentration of Carvedilol can be increased when it is combined with Cyamemazine.Approved
CyclandelateThe risk or severity of hypotension can be increased when Carvedilol is combined with Cyclandelate.Approved
CyclopenthiazideCarvedilol may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
CyclothiazideCyclothiazide may increase the hypotensive activities of Carvedilol.Approved
CymarinCarvedilol may increase the bradycardic activities of Cymarin.Experimental
Cynodon dactylon pollenThe risk of a hypersensitivity reaction to Cynodon dactylon pollen is increased when it is combined with Carvedilol.Approved
Cyproterone acetateThe serum concentration of Carvedilol can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Carvedilol.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Carvedilol.Approved
DabrafenibThe serum concentration of Carvedilol can be decreased when it is combined with Dabrafenib.Approved, Investigational
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Carvedilol.Approved, Investigational
Dactylis glomerata pollenThe risk of a hypersensitivity reaction to Dactylis glomerata pollen is increased when it is combined with Carvedilol.Approved
DalteparinThe risk or severity of hyperkalemia can be increased when Dalteparin is combined with Carvedilol.Approved
DanaparoidThe risk or severity of hyperkalemia can be increased when Danaparoid is combined with Carvedilol.Approved, Withdrawn
DanazolThe metabolism of Carvedilol can be decreased when combined with Danazol.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Carvedilol.Approved
DapiprazoleCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Dapiprazole.Approved
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Carvedilol.Investigational
DarifenacinThe metabolism of Carvedilol can be decreased when combined with Darifenacin.Approved, Investigational
DarodipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Darodipine.Experimental
DarunavirThe serum concentration of Carvedilol can be increased when it is combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Carvedilol.Approved
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Carvedilol.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Carvedilol.Approved, Investigational
DecamethoniumDecamethonium may increase the bradycardic activities of Carvedilol.Approved
DeferasiroxThe serum concentration of Carvedilol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelaprilCarvedilol may increase the hypotensive activities of Delapril.Investigational
DelavirdineThe serum concentration of Carvedilol can be increased when it is combined with Delavirdine.Approved
DemecariumDemecarium may increase the bradycardic activities of Carvedilol.Approved
DeserpidineCarvedilol may increase the hypotensive activities of Deserpidine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Carvedilol.Approved
DeslanosideCarvedilol may increase the bradycardic activities of Deslanoside.Approved
DesvenlafaxineThe serum concentration of Carvedilol can be increased when it is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe therapeutic efficacy of Detomidine can be decreased when used in combination with Carvedilol.Vet Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
DexibuprofenDexibuprofen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
DexketoprofenDexketoprofen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
DexmedetomidineThe therapeutic efficacy of Dexmedetomidine can be decreased when used in combination with Carvedilol.Approved, Vet Approved
DexniguldipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Dexniguldipine.Experimental
DexverapamilThe risk or severity of hypotension can be increased when Carvedilol is combined with Dexverapamil.Experimental
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Carvedilol.Approved, Illicit, Investigational, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Carvedilol.Approved
DichlorvosDichlorvos may increase the bradycardic activities of Carvedilol.Vet Approved
DiclofenacDiclofenac may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Carvedilol is combined with Diclofenamide.Approved, Investigational
DiethylnorspermineCarvedilol may increase the hypotensive activities of Diethylnorspermine.Investigational
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Carvedilol.Approved, Investigational
DifenpiramideDifenpiramide may decrease the antihypertensive activities of Carvedilol.Experimental
DiflunisalDiflunisal may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
DigitoxinCarvedilol may increase the bradycardic activities of Digitoxin.Approved, Investigational
DihydralazineDihydralazine may increase the hypotensive activities of Carvedilol.Approved, Investigational
DihydroergocornineCarvedilol may increase the vasoconstricting activities of Dihydroergocornine.Approved
DihydroergocristineCarvedilol may increase the vasoconstricting activities of Dihydroergocristine.Approved, Experimental
DihydroergocryptineCarvedilol may increase the vasoconstricting activities of Dihydroergocryptine.Experimental
DihydroergotamineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Dihydroergotamine.Approved, Investigational
DiltiazemDiltiazem may increase the hypotensive activities of Carvedilol.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Carvedilol is combined with Dinutuximab.Approved, Investigational
DiphenhydramineThe metabolism of Carvedilol can be decreased when combined with Diphenhydramine.Approved, Investigational
DipivefrinThe therapeutic efficacy of Dipivefrin can be decreased when used in combination with Carvedilol.Approved
DipyridamoleDipyridamole may increase the bradycardic activities of Carvedilol.Approved
DisopyramideDisopyramide may increase the bradycardic activities of Carvedilol.Approved
Distichlis spicata pollenThe risk of a hypersensitivity reaction to Distichlis spicata pollen is increased when it is combined with Carvedilol.Approved
DistigmineDistigmine may increase the bradycardic activities of Carvedilol.Experimental
DixyrazineThe serum concentration of Carvedilol can be increased when it is combined with Dixyrazine.Experimental
DL-MethylephedrineThe therapeutic efficacy of DL-Methylephedrine can be decreased when used in combination with Carvedilol.Approved
DobutamineThe therapeutic efficacy of Dobutamine can be decreased when used in combination with Carvedilol.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Carvedilol.Approved, Investigational
DolutegravirThe serum concentration of Dolutegravir can be increased when it is combined with Carvedilol.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
DonepezilDonepezil may increase the bradycardic activities of Carvedilol.Approved
DopexamineThe therapeutic efficacy of Dopexamine can be decreased when used in combination with Carvedilol.Approved, Investigational
DorzolamideDorzolamide may increase the hypotensive activities of Carvedilol.Approved
DosulepinThe metabolism of Carvedilol can be decreased when combined with Dosulepin.Approved
DotarizineThe risk or severity of hypotension can be increased when Carvedilol is combined with Dotarizine.Investigational
DoxazosinDoxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.Approved
DoxepinCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.Approved, Investigational
DoxofyllineThe therapeutic efficacy of Doxofylline can be decreased when used in combination with Carvedilol.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Carvedilol.Approved, Investigational
DoxycyclineThe metabolism of Carvedilol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DroperidolCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Droperidol.Approved, Vet Approved
DroxicamDroxicam may decrease the antihypertensive activities of Carvedilol.Withdrawn
DroxidopaThe therapeutic efficacy of Droxidopa can be decreased when used in combination with Carvedilol.Approved, Investigational
DuloxetineCarvedilol may increase the orthostatic hypotensive activities of Duloxetine.Approved
EchothiophateEchothiophate may increase the bradycardic activities of Carvedilol.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Carvedilol.Approved
EdrophoniumEdrophonium may increase the bradycardic activities of Carvedilol.Approved
EfavirenzThe serum concentration of Carvedilol can be decreased when it is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Efonidipine.Approved, Investigational
ElagolixThe serum concentration of Elagolix can be increased when it is combined with Carvedilol.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Carvedilol.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Carvedilol.Approved, Investigational
Elymus repens pollenThe risk of a hypersensitivity reaction to Elymus repens pollen is increased when it is combined with Carvedilol.Approved
EmopamilThe risk or severity of hypotension can be increased when Carvedilol is combined with Emopamil.Experimental
EmpagliflozinThe risk or severity of adverse effects can be increased when Carvedilol is combined with Empagliflozin.Approved
EnalaprilEnalapril may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
EnalaprilatCarvedilol may increase the hypotensive activities of Enalaprilat.Approved
EndralazineEndralazine may increase the hypotensive activities of Carvedilol.Experimental
EnoxacinThe metabolism of Carvedilol can be decreased when combined with Enoxacin.Approved, Investigational
EnoxaparinThe risk or severity of hyperkalemia can be increased when Enoxaparin is combined with Carvedilol.Approved
EnzalutamideThe serum concentration of Carvedilol can be decreased when it is combined with Enzalutamide.Approved
EpanololEpanolol may increase the orthostatic hypotensive activities of Carvedilol.Experimental
EperisoneThe risk or severity of hypotension can be increased when Carvedilol is combined with Eperisone.Approved, Investigational
EphedraThe therapeutic efficacy of Ephedra can be decreased when used in combination with Carvedilol.Approved, Nutraceutical, Withdrawn
EphedrineThe therapeutic efficacy of Ephedrine can be decreased when used in combination with Carvedilol.Approved
EpibatidineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Epibatidine.Experimental
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Carvedilol.Approved, Investigational
EpinephrineThe therapeutic efficacy of Epinephrine can be decreased when used in combination with Carvedilol.Approved, Vet Approved
EpirizoleEpirizole may decrease the antihypertensive activities of Carvedilol.Approved
EplerenoneThe risk or severity of adverse effects can be increased when Eplerenone is combined with Carvedilol.Approved
EpoprostenolEpoprostenol may increase the hypotensive activities of Carvedilol.Approved
EprosartanEprosartan may increase the hypotensive activities of Carvedilol.Approved
Ergoloid mesylateCarvedilol may increase the vasoconstricting activities of Ergoloid mesylate.Approved
ErgonovineThe therapeutic efficacy of Ergonovine can be decreased when used in combination with Carvedilol.Approved
ErgotamineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Carvedilol.Approved, Investigational
ErtugliflozinThe serum concentration of Ertugliflozin can be increased when it is combined with Carvedilol.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
EsatenololEsatenolol may increase the orthostatic hypotensive activities of Carvedilol.Experimental
EsmololEsmolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Estradiol acetate can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
Estradiol benzoateThe serum concentration of Estradiol benzoate can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
Estradiol dienanthateThe serum concentration of Estradiol dienanthate can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Carvedilol.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Carvedilol.Approved, Investigational
EtafedrineThe therapeutic efficacy of Etafedrine can be decreased when used in combination with Carvedilol.Approved
EthenzamideEthenzamide may decrease the antihypertensive activities of Carvedilol.Experimental
Ethinyl EstradiolThe serum concentration of Carvedilol can be decreased when it is combined with Ethinyl Estradiol.Approved
EthosuximideThe risk or severity of hypotension can be increased when Carvedilol is combined with Ethosuximide.Approved
EtilefrineThe therapeutic efficacy of Etilefrine can be decreased when used in combination with Carvedilol.Withdrawn
EtodolacEtodolac may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
EtomidateThe therapeutic efficacy of Etomidate can be decreased when used in combination with Carvedilol.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Carvedilol.Approved
EtoricoxibEtoricoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
EtravirineThe serum concentration of Carvedilol can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Carvedilol.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Carvedilol.Approved
FelbamateThe serum concentration of Carvedilol can be increased when it is combined with Felbamate.Approved
FelbinacFelbinac may decrease the antihypertensive activities of Carvedilol.Experimental
FelodipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Felodipine.Approved, Investigational
FenbufenFenbufen may decrease the antihypertensive activities of Carvedilol.Approved
FendilineThe risk or severity of hypotension can be increased when Carvedilol is combined with Fendiline.Withdrawn
FenoldopamFenoldopam may increase the hypotensive activities of Carvedilol.Approved
FenoprofenFenoprofen may decrease the antihypertensive activities of Carvedilol.Approved
FenoterolThe therapeutic efficacy of Fenoterol can be decreased when used in combination with Carvedilol.Approved, Investigational
FentanylFentanyl may increase the bradycardic activities of Carvedilol.Approved, Illicit, Investigational, Vet Approved
FenthionFenthion may increase the bradycardic activities of Carvedilol.Vet Approved
FentiazacFentiazac may decrease the antihypertensive activities of Carvedilol.Experimental
FeprazoneFeprazone may decrease the antihypertensive activities of Carvedilol.Experimental
Ferulic acidCarvedilol may increase the hypotensive activities of Ferulic acid.Experimental
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Carvedilol.Approved
Festuca pratensis pollenThe risk of a hypersensitivity reaction to Festuca pratensis pollen is increased when it is combined with Carvedilol.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Carvedilol.Approved, Investigational
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Carvedilol.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Carvedilol.Approved, Investigational
FingolimodCarvedilol may increase the bradycardic activities of Fingolimod.Approved, Investigational
FirocoxibFirocoxib may decrease the antihypertensive activities of Carvedilol.Experimental, Vet Approved
Fish oilThe risk or severity of hypotension can be increased when Carvedilol is combined with Fish oil.Approved, Nutraceutical
FloctafenineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Floctafenine.Approved, Withdrawn
FloxuridineThe serum concentration of Carvedilol can be increased when it is combined with Floxuridine.Approved
Fluciclovine (18F)The serum concentration of Fluciclovine (18F) can be increased when it is combined with Carvedilol.Approved
FluconazoleThe serum concentration of Carvedilol can be increased when it is combined with Fluconazole.Approved, Investigational
FlunarizineThe risk or severity of hypotension can be increased when Carvedilol is combined with Flunarizine.Approved
FlunixinFlunixin may decrease the antihypertensive activities of Carvedilol.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the antihypertensive activities of Carvedilol.Experimental
FluorouracilThe serum concentration of Carvedilol can be increased when it is combined with Fluorouracil.Approved
FlupentixolCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Flupentixol.Approved, Investigational, Withdrawn
FluphenazineThe serum concentration of Carvedilol can be increased when it is combined with Fluphenazine.Approved
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
FluspirileneThe risk or severity of hypotension can be increased when Carvedilol is combined with Fluspirilene.Approved, Investigational
FluticasoneThe serum concentration of Fluticasone can be increased when it is combined with Carvedilol.Approved, Experimental, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Carvedilol.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Carvedilol.Approved
FluvoxamineThe serum concentration of Carvedilol can be increased when it is combined with Fluvoxamine.Approved, Investigational
ForasartanThe risk or severity of hyperkalemia can be increased when Forasartan is combined with Carvedilol.Experimental
FormoterolThe therapeutic efficacy of Formoterol can be decreased when used in combination with Carvedilol.Approved, Investigational
FosamprenavirThe metabolism of Carvedilol can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Carvedilol can be increased when it is combined with Fosaprepitant.Approved
FosinoprilFosinopril may increase the hypotensive activities of Carvedilol.Approved
FosinoprilatCarvedilol may increase the hypotensive activities of Fosinoprilat.Experimental
FosphenytoinThe metabolism of Carvedilol can be increased when combined with Fosphenytoin.Approved, Investigational
FostamatinibFostamatinib may increase the antihypertensive activities of Carvedilol.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Carvedilol.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Carvedilol.Approved, Vet Approved
Fusidic AcidThe serum concentration of Carvedilol can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe risk or severity of hypotension can be increased when Carvedilol is combined with Gabapentin.Approved, Investigational
GalantamineGalantamine may increase the bradycardic activities of Carvedilol.Approved
Gallamine TriethiodideGallamine Triethiodide may increase the bradycardic activities of Carvedilol.Approved
GallopamilThe risk or severity of hypotension can be increased when Carvedilol is combined with Gallopamil.Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Carvedilol.Approved, Investigational
GemfibrozilThe serum concentration of Carvedilol can be increased when it is combined with Gemfibrozil.Approved
Ginkgo bilobaGinkgo biloba may increase the bradycardic activities of Carvedilol.Approved, Investigational, Nutraceutical
GitoformateCarvedilol may increase the bradycardic activities of Gitoformate.Experimental
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Carvedilol.Approved, Investigational
GlibornurideCarvedilol may increase the hypoglycemic activities of Glibornuride.Investigational, Withdrawn
GliclazideCarvedilol may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideCarvedilol may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideCarvedilol may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GliquidoneCarvedilol may increase the hypoglycemic activities of Gliquidone.Approved, Investigational
GlisoxepideCarvedilol may increase the hypoglycemic activities of Glisoxepide.Investigational
GlyburideCarvedilol may increase the hypoglycemic activities of Glyburide.Approved
Glycerol PhenylbutyrateThe metabolism of Carvedilol can be decreased when combined with Glycerol Phenylbutyrate.Approved
Gramicidin DThe serum concentration of Gramicidin D can be increased when it is combined with Carvedilol.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Carvedilol.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Carvedilol.Approved, Investigational, Withdrawn
GTS-21The risk or severity of adverse effects can be increased when Carvedilol is combined with GTS-21.Investigational
GuacetisalGuacetisal may decrease the antihypertensive activities of Carvedilol.Experimental
GuanabenzThe therapeutic efficacy of Guanabenz can be decreased when used in combination with Carvedilol.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Carvedilol.Approved
GuanazodineCarvedilol may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineCarvedilol may increase the hypotensive activities of Guanethidine.Approved
GuanfacineThe therapeutic efficacy of Guanfacine can be decreased when used in combination with Carvedilol.Approved, Investigational
GuanoclorCarvedilol may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzCarvedilol may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanCarvedilol may increase the hypotensive activities of Guanoxan.Experimental
HaloperidolThe metabolism of Carvedilol can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Carvedilol.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Carvedilol.Experimental
HeparinThe risk or severity of hyperkalemia can be increased when Heparin is combined with Carvedilol.Approved, Investigational
HexamethoniumCarvedilol may increase the hypotensive activities of Hexamethonium.Experimental
HexobarbitalHexobarbital may increase the hypotensive activities of Carvedilol.Approved
HexoprenalineThe therapeutic efficacy of Hexoprenaline can be decreased when used in combination with Carvedilol.Approved, Withdrawn
HigenamineThe therapeutic efficacy of Higenamine can be decreased when used in combination with Carvedilol.Investigational
Holcus lanatus pollenThe risk of a hypersensitivity reaction to Holcus lanatus pollen is increased when it is combined with Carvedilol.Approved
Huperzine AHuperzine A may increase the bradycardic activities of Carvedilol.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Carvedilol.Experimental
HydralazineHydralazine may increase the hypotensive activities of Carvedilol.Approved
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Carvedilol.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Carvedilol.Approved, Investigational
HydroxychloroquineThe risk or severity of QTc prolongation can be decreased when Hydroxychloroquine is combined with Carvedilol.Approved
HydroxyureaThe serum concentration of Hydroxyurea can be increased when it is combined with Carvedilol.Approved
IbuprofenIbuprofen may decrease the antihypertensive activities of Carvedilol.Approved
IbuproxamIbuproxam may decrease the antihypertensive activities of Carvedilol.Withdrawn
IcosapentIcosapent may decrease the antihypertensive activities of Carvedilol.Approved, Nutraceutical
IdelalisibThe metabolism of Carvedilol can be decreased when combined with Idelalisib.Approved
IloperidoneCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Iloperidone.Approved
IloprostIloprost may increase the hypotensive activities of Carvedilol.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Carvedilol.Approved
ImidaprilCarvedilol may increase the hypotensive activities of Imidapril.Investigational
Imidazole salicylateImidazole salicylate may decrease the antihypertensive activities of Carvedilol.Experimental
ImipramineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Imipramine.Approved
IndacaterolThe therapeutic efficacy of Indacaterol can be decreased when used in combination with Carvedilol.Approved
IndalpineThe serum concentration of Carvedilol can be increased when it is combined with Indalpine.Investigational, Withdrawn
IndapamideIndapamide may increase the hypotensive activities of Carvedilol.Approved
IndenololIndenolol may increase the orthostatic hypotensive activities of Carvedilol.Withdrawn
IndinavirThe metabolism of Carvedilol can be decreased when combined with Indinavir.Approved
IndobufenIndobufen may decrease the antihypertensive activities of Carvedilol.Investigational
IndomethacinIndomethacin may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
IndoprofenIndoprofen may decrease the antihypertensive activities of Carvedilol.Withdrawn
IndoraminCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Indoramin.Withdrawn
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Carvedilol.Approved, Investigational
Insulin AspartCarvedilol may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DegludecCarvedilol may increase the hypoglycemic activities of Insulin Degludec.Approved
Insulin DetemirCarvedilol may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineCarvedilol may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineCarvedilol may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanCarvedilol may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproCarvedilol may increase the hypoglycemic activities of Insulin Lispro.Approved
Insulin peglisproCarvedilol may increase the hypoglycemic activities of Insulin peglispro.Investigational
Insulin PorkCarvedilol may increase the hypoglycemic activities of Insulin Pork.Approved
IpidacrineIpidacrine may increase the bradycardic activities of Carvedilol.Experimental
IproniazidIproniazid may increase the hypotensive activities of Carvedilol.Withdrawn
IrbesartanIrbesartan may increase the hypotensive activities of Carvedilol.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Carvedilol.Approved, Investigational
IsavuconazoleThe serum concentration of Carvedilol can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Carvedilol can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Carvedilol.Approved
IsoetarineThe therapeutic efficacy of Isoetarine can be decreased when used in combination with Carvedilol.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Carvedilol.Approved, Vet Approved
IsoflurophateIsoflurophate may increase the bradycardic activities of Carvedilol.Approved, Investigational, Withdrawn
IsomethepteneThe therapeutic efficacy of Isometheptene can be decreased when used in combination with Carvedilol.Approved
IsoniazidThe metabolism of Carvedilol can be decreased when combined with Isoniazid.Approved, Investigational
IsoprenalineThe therapeutic efficacy of Isoprenaline can be decreased when used in combination with Carvedilol.Approved, Investigational
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Isosorbide Dinitrate is combined with Carvedilol.Approved, Investigational
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Isosorbide Mononitrate is combined with Carvedilol.Approved
IsoxicamIsoxicam may decrease the antihypertensive activities of Carvedilol.Withdrawn
IsoxsuprineThe therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Carvedilol.Approved, Withdrawn
IsradipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Isradipine.Approved, Investigational
ItoprideItopride may increase the bradycardic activities of Carvedilol.Investigational
ItraconazoleThe metabolism of Carvedilol can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineCarvedilol may increase the bradycardic activities of Ivabradine.Approved
IvacaftorThe serum concentration of Carvedilol can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
IvosidenibThe serum concentration of Ivosidenib can be increased when it is combined with Carvedilol.Approved, Investigational
KebuzoneKebuzone may decrease the antihypertensive activities of Carvedilol.Experimental
KetanserinKetanserin may increase the hypotensive activities of Carvedilol.Investigational
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Carvedilol.Approved
KetoconazoleThe metabolism of Carvedilol can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenKetoprofen may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
KetorolacKetorolac may decrease the antihypertensive activities of Carvedilol.Approved
Koeleria macrantha pollenThe risk of a hypersensitivity reaction to Koeleria macrantha pollen is increased when it is combined with Carvedilol.Approved
LabetalolLabetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.Approved
LacidipineCarvedilol may increase the hypotensive activities of Lacidipine.Approved, Investigational
LacosamideCarvedilol may increase the atrioventricular blocking (AV block) activities of Lacosamide.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Carvedilol.Approved, Investigational
LamotrigineThe serum concentration of Carvedilol can be decreased when it is combined with Lamotrigine.Approved, Investigational
Lanatoside CCarvedilol may increase the bradycardic activities of Lanatoside C.Experimental
LandiololLandiolol may increase the orthostatic hypotensive activities of Carvedilol.Investigational
LanreotideCarvedilol may increase the bradycardic activities of Lanreotide.Approved
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Carvedilol.Approved, Investigational
LatanoprostLatanoprost may increase the hypotensive activities of Carvedilol.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Carvedilol.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Carvedilol.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Carvedilol.Approved, Investigational
LercanidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Lercanidipine.Approved, Investigational
LetermovirThe serum concentration of Letermovir can be increased when it is combined with Carvedilol.Approved, Investigational
LevetiracetamThe risk or severity of hypotension can be increased when Carvedilol is combined with Levetiracetam.Approved, Investigational
LevobetaxololLevobetaxolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Carvedilol is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Carvedilol.Approved, Investigational
LevodopaCarvedilol may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Carvedilol.Approved, Investigational
LevomilnacipranThe serum concentration of Carvedilol can be increased when it is combined with Levomilnacipran.Approved, Investigational
LevosalbutamolThe therapeutic efficacy of Levosalbutamol can be decreased when used in combination with Carvedilol.Approved, Investigational
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Carvedilol.Approved, Investigational
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Carvedilol.Approved, Vet Approved
LidoflazineThe risk or severity of hypotension can be increased when Carvedilol is combined with Lidoflazine.Experimental
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Carvedilol.Approved
LinezolidLinezolid may increase the hypotensive activities of Carvedilol.Approved, Investigational
LinsidomineCarvedilol may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilLisinopril may increase the hypotensive activities of Carvedilol.Approved, Investigational
LisurideCarvedilol may increase the vasoconstricting activities of Lisuride.Approved, Investigational
LobeglitazoneThe metabolism of Carvedilol can be decreased when combined with Lobeglitazone.Approved, Investigational
LobelineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Lobeline.Investigational
LofexidineThe therapeutic efficacy of Lofexidine can be decreased when used in combination with Carvedilol.Approved, Investigational
Lolium perenne pollenThe risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Carvedilol.Approved
Lolium perenne subsp. multiflorum pollenThe risk of a hypersensitivity reaction to Lolium perenne subsp. multiflorum pollen is increased when it is combined with Carvedilol.Approved
LomerizineThe risk or severity of hypotension can be increased when Carvedilol is combined with Lomerizine.Experimental
LonazolacLonazolac may decrease the antihypertensive activities of Carvedilol.Experimental
LoperamideThe risk or severity of hypotension can be increased when Carvedilol is combined with Loperamide.Approved
LopinavirThe metabolism of Carvedilol can be decreased when combined with Lopinavir.Approved
LorcaserinThe metabolism of Carvedilol can be decreased when combined with Lorcaserin.Approved
LornoxicamLornoxicam may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
LorpiprazoleThe serum concentration of Carvedilol can be increased when it is combined with Lorpiprazole.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Carvedilol.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Carvedilol.Approved, Investigational
LoxoprofenLoxoprofen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
LucinactantCarvedilol may increase the bradycardic activities of Lucinactant.Approved, Investigational
LuliconazoleThe serum concentration of Carvedilol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Carvedilol can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Carvedilol can be decreased when combined with Lumefantrine.Approved
LumiracoxibLumiracoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
Lysergic Acid DiethylamideCarvedilol may increase the vasoconstricting activities of Lysergic Acid Diethylamide.Illicit, Investigational, Withdrawn
MacitentanCarvedilol may increase the hypotensive activities of Macitentan.Approved
Magnesium salicylateMagnesium salicylate may decrease the antihypertensive activities of Carvedilol.Approved
Magnesium sulfateThe risk or severity of hypotension can be increased when Carvedilol is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
MalathionMalathion may increase the bradycardic activities of Carvedilol.Approved, Investigational
ManidipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Manidipine.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Mannitol is combined with Carvedilol.Approved, Investigational
Mannitol busulfanThe risk or severity of hyperkalemia can be increased when Carvedilol is combined with Mannitol busulfan.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Carvedilol.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Carvedilol.Approved, Investigational
Meclofenamic acidMeclofenamic acid may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
MedetomidineThe therapeutic efficacy of Medetomidine can be decreased when used in combination with Carvedilol.Vet Approved
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Carvedilol.Approved
MefloquineThe risk or severity of QTc prolongation can be decreased when Mefloquine is combined with Carvedilol.Approved, Investigational
MeloxicamMeloxicam may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
MelphalanThe serum concentration of Melphalan can be increased when it is combined with Carvedilol.Approved
MentholThe risk or severity of hypotension can be increased when Carvedilol is combined with Menthol.Approved
MephentermineThe therapeutic efficacy of Mephentermine can be decreased when used in combination with Carvedilol.Approved
MepindololMepindolol may increase the orthostatic hypotensive activities of Carvedilol.Experimental
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Carvedilol.Approved, Vet Approved
MesalazineMesalazine may decrease the antihypertensive activities of Carvedilol.Approved
MesoridazineThe serum concentration of Carvedilol can be increased when it is combined with Mesoridazine.Approved, Investigational
MetahexamideCarvedilol may increase the hypoglycemic activities of Metahexamide.Experimental
MetamizoleMetamizole may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Withdrawn
MetaraminolThe therapeutic efficacy of Metaraminol can be decreased when used in combination with Carvedilol.Approved, Investigational
MetergolineCarvedilol may increase the vasoconstricting activities of Metergoline.Experimental
MethacholineCarvedilol may increase the bronchoconstrictory activities of Methacholine.Approved, Investigational
MethadoneThe metabolism of Carvedilol can be decreased when combined with Methadone.Approved
MethamphetamineThe therapeutic efficacy of Methamphetamine can be decreased when used in combination with Carvedilol.Approved, Illicit
Methanesulfonyl FluorideMethanesulfonyl Fluoride may increase the bradycardic activities of Carvedilol.Investigational
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Carvedilol.Approved
MethohexitalMethohexital may increase the hypotensive activities of Carvedilol.Approved
MethoserpidineCarvedilol may increase the hypotensive activities of Methoserpidine.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Carvedilol.Approved
MethotrimeprazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Methotrimeprazine.Approved, Investigational
MethoxamineThe therapeutic efficacy of Methoxamine can be decreased when used in combination with Carvedilol.Approved, Investigational
MethoxyphenamineThe therapeutic efficacy of Methoxyphenamine can be decreased when used in combination with Carvedilol.Experimental
MethsuximideThe risk or severity of hypotension can be increased when Carvedilol is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Carvedilol.Approved
MethyldopaThe therapeutic efficacy of Methyldopa can be decreased when used in combination with Carvedilol.Approved
Methylene blueThe serum concentration of Carvedilol can be increased when it is combined with Methylene blue.Approved, Investigational
MethylergometrineCarvedilol may increase the vasoconstricting activities of Methylergometrine.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Carvedilol.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Carvedilol.Approved, Vet Approved
MethysergideCarvedilol may increase the vasoconstricting activities of Methysergide.Approved
MetildigoxinCarvedilol may increase the bradycardic activities of Metildigoxin.Experimental
MetipranololCarvedilol may increase the hypotensive activities of Metipranolol.Approved
MetoclopramideMetoclopramide may increase the bradycardic activities of Carvedilol.Approved, Investigational
MetolazoneMetolazone may increase the hypotensive activities of Carvedilol.Approved
MetoprololMetoprolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
MetyrosineCarvedilol may increase the hypotensive activities of Metyrosine.Approved
MexiletineThe metabolism of Carvedilol can be decreased when combined with Mexiletine.Approved, Investigational
MibefradilThe risk or severity of hypotension can be increased when Carvedilol is combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Carvedilol can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidostaurinThe serum concentration of Carvedilol can be increased when it is combined with Midostaurin.Approved, Investigational
MifepristoneThe serum concentration of Carvedilol can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe serum concentration of Carvedilol can be increased when it is combined with Milnacipran.Approved, Investigational
MinaprineMinaprine may increase the bradycardic activities of Carvedilol.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Carvedilol.Approved, Investigational
MirabegronThe therapeutic efficacy of Mirabegron can be decreased when used in combination with Carvedilol.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Carvedilol.Investigational
MitomycinThe serum concentration of Mitomycin can be increased when it is combined with Carvedilol.Approved
MitotaneThe serum concentration of Carvedilol can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Carvedilol.Approved, Investigational
MoclobemideMoclobemide may increase the hypotensive activities of Carvedilol.Approved, Investigational
ModafinilThe serum concentration of Carvedilol can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilMoexipril may increase the hypotensive activities of Carvedilol.Approved
MofebutazoneMofebutazone may decrease the antihypertensive activities of Carvedilol.Experimental
MolsidomineMolsidomine may increase the hypotensive activities of Carvedilol.Approved, Investigational
MoricizineThe serum concentration of Carvedilol can be increased when it is combined with Moricizine.Approved, Investigational, Withdrawn
MorniflumateMorniflumate may decrease the antihypertensive activities of Carvedilol.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Carvedilol.Approved, Investigational
MoxidectinThe serum concentration of Moxidectin can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
MoxonidineThe therapeutic efficacy of Moxonidine can be decreased when used in combination with Carvedilol.Approved, Investigational
MuzolimineCarvedilol may increase the hypotensive activities of Muzolimine.Experimental
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Carvedilol.Approved, Investigational
NabiloneThe serum concentration of Carvedilol can be increased when it is combined with Nabilone.Approved, Investigational
NabumetoneNabumetone may decrease the antihypertensive activities of Carvedilol.Approved
NadololNadolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
NadroparinThe risk or severity of hyperkalemia can be increased when Nadroparin is combined with Carvedilol.Approved, Investigational
NafcillinThe serum concentration of Carvedilol can be decreased when it is combined with Nafcillin.Approved, Investigational
NaftopidilThe risk or severity of hypotension can be increased when Carvedilol is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Carvedilol.Approved
NaloxoneThe metabolism of Carvedilol can be decreased when combined with Naloxone.Approved, Vet Approved
NaphazolineThe therapeutic efficacy of Naphazoline can be decreased when used in combination with Carvedilol.Approved
NaproxenNaproxen may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
NebivololThe therapeutic efficacy of Nebivolol can be decreased when used in combination with Carvedilol.Approved, Investigational
NefazodoneCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Carvedilol can be decreased when it is combined with Nelfinavir.Approved
NeostigmineNeostigmine may increase the bradycardic activities of Carvedilol.Approved, Vet Approved
NepafenacNepafenac may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Carvedilol is combined with Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Carvedilol can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Carvedilol can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Carvedilol.Withdrawn
NicergolineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nicergoline.Approved, Investigational
NicorandilNicorandil may increase the hypotensive activities of Carvedilol.Approved, Investigational
NicotineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Nicotine.Approved
NifedipineThe risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Carvedilol.Approved
NifenazoneNifenazone may decrease the antihypertensive activities of Carvedilol.Experimental
Niflumic AcidNiflumic Acid may decrease the antihypertensive activities of Carvedilol.Approved
NiguldipineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Niguldipine.Experimental
NilotinibThe metabolism of Carvedilol can be decreased when combined with Nilotinib.Approved, Investigational
NiludipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Niludipine.Experimental
NilvadipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Nilvadipine.Approved, Investigational
NimesulideNimesulide may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Withdrawn
NimodipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Nimodipine.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Carvedilol.Approved
NisoldipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Nisoldipine.Approved
NitrendipineThe risk or severity of hypotension can be increased when Carvedilol is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Carvedilol.Approved
NitroaspirinNitroaspirin may decrease the antihypertensive activities of Carvedilol.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Carvedilol.Approved, Investigational
NitroprussideNitroprusside may increase the hypotensive activities of Carvedilol.Approved, Investigational
Nitrous acidThe risk or severity of adverse effects can be increased when Nitrous acid is combined with Carvedilol.Approved, Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Carvedilol.Approved
NN344Carvedilol may increase the hypoglycemic activities of NN344.Investigational
NorepinephrineThe therapeutic efficacy of Norepinephrine can be decreased when used in combination with Carvedilol.Approved
NorfenefrineThe therapeutic efficacy of Norfenefrine can be decreased when used in combination with Carvedilol.Experimental
NortriptylineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nortriptyline.Approved
NS-398NS-398 may decrease the antihypertensive activities of Carvedilol.Experimental
NylidrinThe therapeutic efficacy of Nylidrin can be decreased when used in combination with Carvedilol.Approved
ObinutuzumabCarvedilol may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Carvedilol.Withdrawn
OctopamineThe therapeutic efficacy of Octopamine can be decreased when used in combination with Carvedilol.Experimental
OctreotideThe serum concentration of Octreotide can be increased when it is combined with Carvedilol.Approved, Investigational
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Carvedilol.Investigational
OlanzapineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Olanzapine.Approved, Investigational
OlaparibThe metabolism of Carvedilol can be decreased when combined with Olaparib.Approved
OleandrinCarvedilol may increase the bradycardic activities of Oleandrin.Experimental, Investigational
OlmesartanOlmesartan may increase the hypotensive activities of Carvedilol.Approved, Investigational
OlodaterolThe therapeutic efficacy of Olodaterol can be decreased when used in combination with Carvedilol.Approved
OlsalazineOlsalazine may decrease the antihypertensive activities of Carvedilol.Approved
OmapatrilatOmapatrilat may increase the hypotensive activities of Carvedilol.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Carvedilol.Approved, Investigational
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Carvedilol.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Carvedilol.Approved
OrciprenalineThe therapeutic efficacy of Orciprenaline can be decreased when used in combination with Carvedilol.Approved
OtiloniumThe risk or severity of hypotension can be increased when Carvedilol is combined with Otilonium.Experimental, Investigational
OuabainCarvedilol may increase the bradycardic activities of Ouabain.Approved
OxaprozinOxaprozin may decrease the antihypertensive activities of Carvedilol.Approved
OxcarbazepineThe serum concentration of Carvedilol can be decreased when it is combined with Oxcarbazepine.Approved
OxprenololOxprenolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
OxyfedrineThe therapeutic efficacy of Oxyfedrine can be decreased when used in combination with Carvedilol.Experimental
OxymetazolineThe therapeutic efficacy of Oxymetazoline can be decreased when used in combination with Carvedilol.Approved, Investigational
OxyphenbutazoneOxyphenbutazone may decrease the antihypertensive activities of Carvedilol.Approved, Withdrawn
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Carvedilol.Approved, Vet Approved
PalbociclibThe serum concentration of Carvedilol can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Paliperidone.Approved
PanobinostatThe serum concentration of Carvedilol can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Carvedilol.Approved
PapaverineThe risk or severity of adverse effects can be increased when Papaverine is combined with Carvedilol.Approved, Investigational
ParaoxonParaoxon may increase the bradycardic activities of Carvedilol.Experimental
ParecoxibParecoxib may decrease the antihypertensive activities of Carvedilol.Approved
PargylinePargyline may increase the hypotensive activities of Carvedilol.Approved
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Carvedilol.Approved, Investigational
ParnaparinThe risk or severity of hyperkalemia can be increased when Parnaparin is combined with Carvedilol.Approved, Investigational
ParoxetineThe serum concentration of Carvedilol can be increased when it is combined with Paroxetine.Approved, Investigational
Pascopyrum smithii pollenThe risk of a hypersensitivity reaction to Pascopyrum smithii pollen is increased when it is combined with Carvedilol.Approved
PasireotideCarvedilol may increase the bradycardic activities of Pasireotide.Approved
Paspalum notatum pollenThe risk of a hypersensitivity reaction to Paspalum notatum pollen is increased when it is combined with Carvedilol.Approved
Patent BlueThe therapeutic efficacy of Carvedilol can be decreased when used in combination with Patent Blue.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Carvedilol.Approved
Peginterferon alfa-2bThe serum concentration of Carvedilol can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenbutololPenbutolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
PenfluridolThe risk or severity of hypotension can be increased when Carvedilol is combined with Penfluridol.Experimental
Penicillin G Acyl-SerineThe risk or severity of hyperkalemia can be increased when Carvedilol is combined with Penicillin G Acyl-Serine.Experimental
PentamidineThe risk or severity of hyperkalemia can be increased when Carvedilol is combined with Pentamidine.Approved, Investigational
PentazocineThe serum concentration of Pentazocine can be increased when it is combined with Carvedilol.Approved, Vet Approved
PentobarbitalPentobarbital may increase the hypotensive activities of Carvedilol.Approved, Investigational, Vet Approved
PentoliniumPentolinium may increase the hypotensive activities of Carvedilol.Approved
PerazineThe serum concentration of Carvedilol can be increased when it is combined with Perazine.Approved, Investigational
PergolideThe therapeutic efficacy of Pergolide can be decreased when used in combination with Carvedilol.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilPerindopril may increase the hypotensive activities of Carvedilol.Approved
PerindoprilatCarvedilol may increase the hypotensive activities of Perindoprilat.Experimental
PerphenazineThe serum concentration of Carvedilol can be increased when it is combined with Perphenazine.Approved
PeruvosideCarvedilol may increase the bradycardic activities of Peruvoside.Experimental
PF-00610355The therapeutic efficacy of PF-00610355 can be decreased when used in combination with Carvedilol.Investigational
Phalaris arundinacea pollenThe risk of a hypersensitivity reaction to Phalaris arundinacea pollen is increased when it is combined with Carvedilol.Approved
Phalaris minor pollenThe risk of a hypersensitivity reaction to Phalaris minor pollen is increased when it is combined with Carvedilol.Approved
PhendimetrazineThe therapeutic efficacy of Phendimetrazine can be decreased when used in combination with Carvedilol.Approved, Illicit
PhenelzinePhenelzine may increase the hypotensive activities of Carvedilol.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Carvedilol.Withdrawn
PhenobarbitalThe serum concentration of Carvedilol can be decreased when it is combined with Phenobarbital.Approved, Investigational
PhenothiazineThe serum concentration of Phenothiazine can be increased when it is combined with Carvedilol.Vet Approved
PhenoxybenzamineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Carvedilol.Withdrawn
PhentolamineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phentolamine.Approved
PhenylbutazonePhenylbutazone may decrease the antihypertensive activities of Carvedilol.Approved, Vet Approved
Phenylbutyric acidThe metabolism of Carvedilol can be decreased when combined with Phenylbutyric acid.Approved, Investigational
PhenylephrineThe therapeutic efficacy of Phenylephrine can be decreased when used in combination with Carvedilol.Approved
PhenylpropanolamineThe therapeutic efficacy of Phenylpropanolamine can be decreased when used in combination with Carvedilol.Approved, Vet Approved, Withdrawn
PhenytoinThe serum concentration of Carvedilol can be decreased when it is combined with Phenytoin.Approved, Vet Approved
Phleum pratense pollenThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Carvedilol.Approved, Investigational
PhysostigminePhysostigmine may increase the bradycardic activities of Carvedilol.Approved, Investigational
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Carvedilol.Approved, Investigational
PilocarpineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Pilocarpine.Approved, Investigational
PinacidilPinacidil may increase the hypotensive activities of Carvedilol.Approved
PinaveriumThe risk or severity of hypotension can be increased when Carvedilol is combined with Pinaverium.Approved
PindololPindolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Carvedilol.Approved, Investigational
PiperineThe serum concentration of Carvedilol can be increased when it is combined with Piperine.Investigational
PipotiazineThe serum concentration of Carvedilol can be increased when it is combined with Pipotiazine.Approved, Investigational
PirbuterolThe therapeutic efficacy of Pirbuterol can be decreased when used in combination with Carvedilol.Approved
PirlindolePirlindole may increase the hypotensive activities of Carvedilol.Approved
PiroxicamPiroxicam may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
PirprofenPirprofen may decrease the antihypertensive activities of Carvedilol.Experimental
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Carvedilol.Approved
PitolisantThe serum concentration of Carvedilol can be decreased when it is combined with Pitolisant.Approved, Investigational
PivhydrazinePivhydrazine may increase the hypotensive activities of Carvedilol.Withdrawn
PizotifenCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Pizotifen.Approved
Poa annua pollenThe risk of a hypersensitivity reaction to Poa annua pollen is increased when it is combined with Carvedilol.Approved
Poa compressa pollenThe risk of a hypersensitivity reaction to Poa compressa pollen is increased when it is combined with Carvedilol.Approved
Poa pratensis pollenThe risk of a hypersensitivity reaction to Poa pratensis pollen is increased when it is combined with Carvedilol.Approved
PolythiazideCarvedilol may increase the hypotensive activities of Polythiazide.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Carvedilol.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Carvedilol.Approved, Investigational
Poractant alfaCarvedilol may increase the bradycardic activities of Poractant alfa.Approved
PosaconazoleThe metabolism of Carvedilol can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium acetateThe risk or severity of hyperkalemia can be increased when Potassium acetate is combined with Carvedilol.Approved, Investigational
Potassium bicarbonateThe risk or severity of hyperkalemia can be increased when Potassium bicarbonate is combined with Carvedilol.Approved
Potassium cationThe risk or severity of hyperkalemia can be increased when Potassium cation is combined with Carvedilol.Approved, Investigational
Potassium ChlorideThe risk or severity of hyperkalemia can be increased when Potassium Chloride is combined with Carvedilol.Approved, Withdrawn
Potassium CitrateThe risk or severity of hyperkalemia can be increased when Potassium Citrate is combined with Carvedilol.Approved, Investigational, Vet Approved
PractololPractolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Carvedilol.Approved, Investigational
PranoprofenPranoprofen may decrease the antihypertensive activities of Carvedilol.Experimental, Investigational
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Carvedilol.Approved
PrazosinPrazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Carvedilol.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Carvedilol.Approved, Vet Approved
PrenalterolThe therapeutic efficacy of Prenalterol can be decreased when used in combination with Carvedilol.Experimental
PrenylamineThe risk or severity of hypotension can be increased when Carvedilol is combined with Prenylamine.Withdrawn
PrimaquineThe risk or severity of QTc prolongation can be decreased when Primaquine is combined with Carvedilol.Approved
PrimidoneThe serum concentration of Carvedilol can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcaterolThe therapeutic efficacy of Procaterol can be decreased when used in combination with Carvedilol.Approved, Investigational
ProchlorperazineThe serum concentration of Carvedilol can be increased when it is combined with Prochlorperazine.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the antihypertensive activities of Carvedilol.Experimental
PromazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Promazine.Approved, Vet Approved
PromethazineThe serum concentration of Carvedilol can be increased when it is combined with Promethazine.Approved, Investigational
PropacetamolPropacetamol may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
PropafenoneThe risk or severity of adverse effects can be increased when Propafenone is combined with Carvedilol.Approved
PropericiazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Propericiazine.Approved, Investigational
PropiomazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Propiomazine.Approved
PropiopromazineThe serum concentration of Carvedilol can be increased when it is combined with Propiopromazine.Vet Approved
PropiverineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Propiverine.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Carvedilol.Approved, Investigational, Vet Approved
PropranololPropranolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
PropyphenazonePropyphenazone may decrease the antihypertensive activities of Carvedilol.Experimental
ProquazoneProquazone may decrease the antihypertensive activities of Carvedilol.Experimental
ProscillaridinCarvedilol may increase the bradycardic activities of Proscillaridin.Experimental
ProtokylolThe therapeutic efficacy of Protokylol can be decreased when used in combination with Carvedilol.Approved, Vet Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Carvedilol.Approved
PseudoephedrineThe therapeutic efficacy of Pseudoephedrine can be decreased when used in combination with Carvedilol.Approved
PyridostigminePyridostigmine may increase the bradycardic activities of Carvedilol.Approved, Investigational
QuetiapineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quetiapine.Approved
QuinaprilQuinapril may increase the hypotensive activities of Carvedilol.Approved, Investigational
QuinaprilatCarvedilol may increase the hypotensive activities of Quinaprilat.Experimental
QuinidineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quinidine.Approved, Investigational
QuinineThe metabolism of Carvedilol can be increased when combined with Quinine.Approved
RacepinephrineThe therapeutic efficacy of Racepinephrine can be decreased when used in combination with Carvedilol.Approved
RactopamineThe therapeutic efficacy of Ractopamine can be decreased when used in combination with Carvedilol.Vet Approved
RamiprilRamipril may increase the hypotensive activities of Carvedilol.Approved
RamiprilatCarvedilol may increase the hypotensive activities of Ramiprilat.Experimental
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Carvedilol.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Carvedilol.Approved, Investigational
RasagilineRasagiline may increase the hypotensive activities of Carvedilol.Approved
RegorafenibRegorafenib may increase the bradycardic activities of Carvedilol.Approved
RemifentanilRemifentanil may increase the bradycardic activities of Carvedilol.Approved
RemikirenRemikiren may increase the hypotensive activities of Carvedilol.Approved
ReproterolThe therapeutic efficacy of Reproterol can be decreased when used in combination with Carvedilol.Investigational
RescinnamineCarvedilol may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Carvedilol.Approved, Investigational
ReviparinThe risk or severity of hyperkalemia can be increased when Reviparin is combined with Carvedilol.Approved, Investigational
RheinThe metabolism of Carvedilol can be decreased when combined with Rhein.Experimental
Rhodamine 6GThe serum concentration of Rhodamine 6G can be increased when it is combined with Carvedilol.Experimental
RifampicinThe serum concentration of Carvedilol can be decreased when it is combined with Rifampicin.Approved
RifamycinThe metabolism of Carvedilol can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Carvedilol can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Carvedilol.Approved, Investigational
RilmenidineThe therapeutic efficacy of Rilmenidine can be decreased when used in combination with Carvedilol.Approved, Investigational
RimexoloneThe metabolism of Carvedilol can be increased when combined with Rimexolone.Approved
RimiterolThe therapeutic efficacy of Rimiterol can be decreased when used in combination with Carvedilol.Experimental
RiociguatCarvedilol may increase the hypotensive activities of Riociguat.Approved
RitanserinThe serum concentration of Carvedilol can be increased when it is combined with Ritanserin.Investigational
RitobegronThe therapeutic efficacy of Ritobegron can be decreased when used in combination with Carvedilol.Investigational
RitodrineThe therapeutic efficacy of Ritodrine can be decreased when used in combination with Carvedilol.Approved, Investigational
RitonavirThe serum concentration of Carvedilol can be decreased when it is combined with Ritonavir.Approved, Investigational
RituximabCarvedilol may increase the hypotensive activities of Rituximab.Approved
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Carvedilol.Approved
RivastigmineCarvedilol may increase the bradycardic activities of Rivastigmine.Approved, Investigational
RobenacoxibRobenacoxib may decrease the antihypertensive activities of Carvedilol.Experimental, Vet Approved
RofecoxibRofecoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Withdrawn
RolapitantThe metabolism of Carvedilol can be decreased when combined with Rolapitant.Approved, Investigational
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Carvedilol.Approved, Investigational
RomifidineThe therapeutic efficacy of Romifidine can be decreased when used in combination with Carvedilol.Vet Approved
RopiniroleThe therapeutic efficacy of Ropinirole can be decreased when used in combination with Carvedilol.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Carvedilol.Approved
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Carvedilol.Approved
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Carvedilol.Approved, Investigational
RuxolitinibRuxolitinib may increase the bradycardic activities of Carvedilol.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Carvedilol.Approved
SafinamideSafinamide may increase the hypotensive activities of Carvedilol.Approved, Investigational
SafrazineSafrazine may increase the hypotensive activities of Carvedilol.Withdrawn
SalbutamolThe therapeutic efficacy of Salbutamol can be decreased when used in combination with Carvedilol.Approved, Vet Approved
SalicylamideSalicylamide may decrease the antihypertensive activities of Carvedilol.Approved
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Vet Approved
SalmeterolThe therapeutic efficacy of Salmeterol can be decreased when used in combination with Carvedilol.Approved
SalsalateSalsalate may decrease the antihypertensive activities of Carvedilol.Approved
SaprisartanCarvedilol may increase the hypotensive activities of Saprisartan.Experimental
SaquinavirThe metabolism of Carvedilol can be decreased when combined with Saquinavir.Approved, Investigational
SaralasinThe risk or severity of hyperkalemia can be increased when Saralasin is combined with Carvedilol.Investigational
SarilumabThe therapeutic efficacy of Carvedilol can be decreased when used in combination with Sarilumab.Approved, Investigational
SC-236SC-236 may decrease the antihypertensive activities of Carvedilol.Experimental, Investigational
Secale cereale pollenThe risk of a hypersensitivity reaction to Secale cereale pollen is increased when it is combined with Carvedilol.Approved
SecobarbitalSecobarbital may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Carvedilol.Approved, Investigational, Vet Approved
SeletracetamThe risk or severity of hypotension can be increased when Carvedilol is combined with Seletracetam.Investigational
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Carvedilol.Approved
SertralineThe serum concentration of Carvedilol can be increased when it is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Carvedilol.Approved, Vet Approved
SildenafilSildenafil may increase the antihypertensive activities of Carvedilol.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Carvedilol.Approved
SiltuximabThe serum concentration of Carvedilol can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Carvedilol can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Carvedilol.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Carvedilol.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Carvedilol.Approved, Investigational
SitaxentanCarvedilol may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Carvedilol.Approved
SolabegronThe therapeutic efficacy of Solabegron can be decreased when used in combination with Carvedilol.Investigational
SomatostatinThe serum concentration of Somatostatin can be increased when it is combined with Carvedilol.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Carvedilol.Approved, Investigational
Sorghum bicolor subsp. drummondii pollenThe risk of a hypersensitivity reaction to Sorghum bicolor subsp. drummondii pollen is increased when it is combined with Carvedilol.Approved
Sorghum halepense pollenThe risk of a hypersensitivity reaction to Sorghum halepense pollen is increased when it is combined with Carvedilol.Approved
SotalolSotalol may increase the orthostatic hypotensive activities of Carvedilol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Carvedilol.Approved, Investigational
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Carvedilol.Experimental
SpiraprilCarvedilol may increase the hypotensive activities of Spirapril.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Carvedilol.Approved
St. John's WortThe serum concentration of Carvedilol can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StanoloneThe serum concentration of Stanolone can be increased when it is combined with Carvedilol.Illicit, Investigational
Stanolone acetateThe serum concentration of Stanolone acetate can be increased when it is combined with Carvedilol.Experimental
StiripentolThe serum concentration of Carvedilol can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Carvedilol.Approved, Investigational
SuccinylcholineThe risk or severity of hyperkalemia can be increased when Carvedilol is combined with Succinylcholine.Approved
SufentanilSufentanil may increase the bradycardic activities of Carvedilol.Approved, Investigational
SulconazoleThe metabolism of Carvedilol can be decreased when combined with Sulconazole.Approved
SulfasalazineSulfasalazine may decrease the antihypertensive activities of Carvedilol.Approved
SulindacSulindac may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
SulodexideThe risk or severity of hyperkalemia can be increased when Sulodexide is combined with Carvedilol.Approved, Investigational
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Carvedilol.Approved, Investigational
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Carvedilol.Approved, Investigational
SuprofenSuprofen may decrease the antihypertensive activities of Carvedilol.Approved, Withdrawn
SuxibuzoneSuxibuzone may decrease the antihypertensive activities of Carvedilol.Experimental
SynephrineThe therapeutic efficacy of Synephrine can be decreased when used in combination with Carvedilol.Experimental
TacrineTacrine may increase the bradycardic activities of Carvedilol.Investigational, Withdrawn
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Carvedilol.Approved, Investigational
TadalafilTadalafil may increase the antihypertensive activities of Carvedilol.Approved, Investigational
TalinololTalinolol may increase the orthostatic hypotensive activities of Carvedilol.Investigational
TalniflumateTalniflumate may decrease the antihypertensive activities of Carvedilol.Approved
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Carvedilol.Approved
TamsulosinTamsulosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.Approved, Investigational
TasosartanThe risk or severity of hyperkalemia can be increased when Tasosartan is combined with Carvedilol.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Carvedilol.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Carvedilol.Approved, Investigational
TelaprevirThe metabolism of Carvedilol can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Carvedilol can be decreased when combined with Telithromycin.Approved
TelmisartanTelmisartan may increase the hypotensive activities of Carvedilol.Approved, Investigational
TemocaprilCarvedilol may increase the hypotensive activities of Temocapril.Experimental, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Carvedilol.Approved
TenidapTenidap may decrease the antihypertensive activities of Carvedilol.Experimental
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Carvedilol.Approved
TenoxicamTenoxicam may decrease the antihypertensive activities of Carvedilol.Approved
TepoxalinTepoxalin may decrease the antihypertensive activities of Carvedilol.Vet Approved
TerazosinCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.Approved
TerbinafineThe metabolism of Carvedilol can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineThe therapeutic efficacy of Terbutaline can be decreased when used in combination with Carvedilol.Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Carvedilol.Approved, Withdrawn
TergurideCarvedilol may increase the vasoconstricting activities of Terguride.Experimental
TeriflunomideThe serum concentration of Carvedilol can be decreased when it is combined with Teriflunomide.Approved
TerodilineThe risk or severity of hypotension can be increased when Carvedilol is combined with Terodiline.Experimental
TertatololTertatolol may increase the orthostatic hypotensive activities of Carvedilol.Experimental
Testosterone propionateThe serum concentration of Carvedilol can be decreased when it is combined with Testosterone propionate.Approved, Investigational, Vet Approved, Withdrawn
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Carvedilol.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of hypotension can be increased when Carvedilol is combined with Tetrahydropalmatine.Investigational
TetrandrineThe risk or severity of hypotension can be increased when Carvedilol is combined with Tetrandrine.Experimental
TetryzolineThe therapeutic efficacy of Tetryzoline can be decreased when used in combination with Carvedilol.Approved
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Carvedilol.Approved, Investigational, Withdrawn
TheophyllineTheophylline may increase the antihypertensive activities of Carvedilol.Approved
ThiamylalThiamylal may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
ThiazinamThe serum concentration of Carvedilol can be increased when it is combined with Thiazinam.Experimental
ThiethylperazineThe serum concentration of Carvedilol can be increased when it is combined with Thiethylperazine.Withdrawn
ThiopentalThiopental may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
ThioproperazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Thioproperazine.Approved
ThioridazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Thioridazine.Approved, Withdrawn
ThiothixeneThe metabolism of Carvedilol can be decreased when combined with Thiothixene.Approved
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Carvedilol.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Carvedilol.Approved
TicrynafenCarvedilol may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololTimolol may increase the orthostatic hypotensive activities of Carvedilol.Approved
TinoridineTinoridine may decrease the antihypertensive activities of Carvedilol.Investigational
TinzaparinThe risk or severity of hyperkalemia can be increased when Tinzaparin is combined with Carvedilol.Approved
TipranavirThe serum concentration of Carvedilol can be decreased when it is combined with Tipranavir.Approved, Investigational
TizanidineThe therapeutic efficacy of Tizanidine can be decreased when used in combination with Carvedilol.Approved, Investigational
TocilizumabThe serum concentration of Carvedilol can be decreased when it is combined with Tocilizumab.Approved
TocopherylquinoneCarvedilol may increase the hypotensive activities of Tocopherylquinone.Experimental, Investigational
TofacitinibTofacitinib may increase the bradycardic activities of Carvedilol.Approved, Investigational
TolazamideCarvedilol may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolazolineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tolazoline.Approved, Vet Approved
TolbutamideCarvedilol may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Carvedilol.Approved, Withdrawn
Tolfenamic AcidTolfenamic Acid may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
TolmetinTolmetin may decrease the antihypertensive activities of Carvedilol.Approved
TolonidineCarvedilol may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Carvedilol.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Carvedilol.Approved
TopiramateThe serum concentration of Topiramate can be increased when it is combined with Carvedilol.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Carvedilol.Approved, Investigational
TorasemideTorasemide may increase the hypotensive activities of Carvedilol.Approved
TrandolaprilTrandolapril may increase the hypotensive activities of Carvedilol.Approved
TranilastThe risk or severity of hypotension can be increased when Carvedilol is combined with Tranilast.Approved, Investigational
TranylcypromineTranylcypromine may increase the hypotensive activities of Carvedilol.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Carvedilol.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Carvedilol.Approved
TrazodoneCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trazodone.Approved, Investigational
TreprostinilTreprostinil may increase the hypotensive activities of Carvedilol.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Carvedilol.Approved, Investigational, Nutraceutical
TretoquinolThe therapeutic efficacy of Tretoquinol can be decreased when used in combination with Carvedilol.Experimental
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Carvedilol.Approved
TrichlorfonTrichlorfon may increase the bradycardic activities of Carvedilol.Vet Approved
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Carvedilol.Approved, Vet Approved
TrifluoperazineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trifluoperazine.Approved, Investigational
TriflupromazineThe serum concentration of Carvedilol can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimazosinCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trimazosin.Experimental
TrimebutineThe risk or severity of hypotension can be increased when Carvedilol is combined with Trimebutine.Approved
TrimethadioneThe risk or severity of hypotension can be increased when Carvedilol is combined with Trimethadione.Approved
TrimethaphanTrimethaphan may increase the hypotensive activities of Carvedilol.Approved, Investigational
TrimethoprimThe risk or severity of hyperkalemia can be increased when Carvedilol is combined with Trimethoprim.Approved, Vet Approved
TrimipramineCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Trimipramine.Approved
Trolamine salicylateTrolamine salicylate may decrease the antihypertensive activities of Carvedilol.Approved
TroleandomycinThe metabolism of Carvedilol can be decreased when combined with Troleandomycin.Approved
TubocurarineTubocurarine may increase the bradycardic activities of Carvedilol.Approved
TulobuterolThe therapeutic efficacy of Tulobuterol can be decreased when used in combination with Carvedilol.Investigational
TyrothricinTyrothricin may increase the bradycardic activities of Carvedilol.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Carvedilol.Approved, Investigational, Nutraceutical
UdenafilUdenafil may increase the antihypertensive activities of Carvedilol.Approved, Investigational
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Carvedilol.Approved
UnoprostoneCarvedilol may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Urapidil.Investigational
Urochloa mutica pollenThe risk of a hypersensitivity reaction to Urochloa mutica pollen is increased when it is combined with Carvedilol.Approved
ValaciclovirThe risk or severity of adverse effects can be increased when Carvedilol is combined with Valaciclovir.Approved, Investigational
ValdecoxibValdecoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Withdrawn
ValinomycinThe serum concentration of Valinomycin can be increased when it is combined with Carvedilol.Experimental
Valproic AcidThe serum concentration of Carvedilol can be increased when it is combined with Valproic Acid.Approved, Investigational
ValsartanValsartan may increase the hypotensive activities of Carvedilol.Approved, Investigational
ValspodarThe serum concentration of Valspodar can be increased when it is combined with Carvedilol.Investigational
VardenafilVardenafil may increase the antihypertensive activities of Carvedilol.Approved
VareniclineThe risk or severity of adverse effects can be increased when Carvedilol is combined with Varenicline.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Carvedilol.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Carvedilol.Approved, Investigational
VemurafenibThe serum concentration of Carvedilol can be increased when it is combined with Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Carvedilol.Approved, Investigational
VenlafaxineThe serum concentration of Carvedilol can be increased when it is combined with Venlafaxine.Approved
VerapamilCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Verapamil.Approved
VilanterolThe therapeutic efficacy of Vilanterol can be decreased when used in combination with Carvedilol.Approved
VilazodoneThe metabolism of Carvedilol can be decreased when combined with Vilazodone.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Carvedilol.Approved
VincamineCarvedilol may increase the hypotensive activities of Vincamine.Experimental
VincristineThe excretion of Vincristine can be decreased when combined with Carvedilol.Approved, Investigational
VinflunineThe serum concentration of Vinflunine can be increased when it is combined with Carvedilol.Approved, Investigational
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Carvedilol.Approved, Investigational
VinpocetineThe risk or severity of hypotension can be increased when Carvedilol is combined with Vinpocetine.Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Carvedilol.Approved, Investigational
VoriconazoleThe metabolism of Carvedilol can be decreased when combined with Voriconazole.Approved, Investigational
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Carvedilol.Approved, Investigational
WIN 55212-2The risk or severity of hypotension can be increased when Carvedilol is combined with WIN 55212-2.Experimental
XamoterolThe therapeutic efficacy of Xamoterol can be decreased when used in combination with Carvedilol.Experimental
XipamideCarvedilol may increase the hypotensive activities of Xipamide.Experimental
XylazineThe therapeutic efficacy of Xylazine can be decreased when used in combination with Carvedilol.Vet Approved
XylometazolineThe therapeutic efficacy of Xylometazoline can be decreased when used in combination with Carvedilol.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Carvedilol.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Carvedilol can be decreased when combined with Zafirlukast.Approved, Investigational
ZaltoprofenZaltoprofen may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
ZiconotideThe risk or severity of hypotension can be increased when Carvedilol is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Carvedilol can be decreased when it is combined with Zidovudine.Approved
ZimelidineThe serum concentration of Carvedilol can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Ziprasidone.Approved
ZofenoprilCarvedilol may increase the hypotensive activities of Zofenopril.Experimental
ZomepiracZomepirac may decrease the antihypertensive activities of Carvedilol.Withdrawn
ZonisamideThe risk or severity of hypotension can be increased when Carvedilol is combined with Zonisamide.Approved, Investigational
ZucapsaicinThe metabolism of Carvedilol can be decreased when combined with Zucapsaicin.Approved, Investigational
ZuclopenthixolCarvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Take with food, food slows the absorption rate and reduces the incidence of adverse effects (extent of absorption is not affected).

References

Synthesis Reference

Ilan Kor, "Crystalline solids of carvedilol and processes for their preparation." U.S. Patent US20030166702, issued September 04, 2003.

US20030166702
General References
  1. Packer M, Fowler MB, Roecker EB, Coats AJ, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Staiger C, Holcslaw TL, Amann-Zalan I, DeMets DL: Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation. 2002 Oct 22;106(17):2194-9. [PubMed:12390947]
  2. Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Castaigne A, Roecker EB, Schultz MK, DeMets DL: Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001 May 31;344(22):1651-8. [PubMed:11386263]
  3. Vanderhoff BT, Ruppel HM, Amsterdam PB: Carvedilol: the new role of beta blockers in congestive heart failure. Am Fam Physician. 1998 Nov 1;58(7):1627-34, 1641-2. [PubMed:9824960]
External Links
Human Metabolome Database
HMDB0015267
KEGG Drug
D00255
KEGG Compound
C06875
PubChem Compound
2585
PubChem Substance
46505146
ChemSpider
2487
BindingDB
25759
ChEBI
3441
ChEMBL
CHEMBL723
Therapeutic Targets Database
DAP000135
PharmGKB
PA448817
IUPHAR
551
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Carvedilol
ATC Codes
C07AG02 — Carvedilol
AHFS Codes
  • 24:24.00 — Beta-adrenergic Blocking Agents
FDA label
Download (1.25 MB)
MSDS
Download (32.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingBasic ScienceSleep / Sleep Deprivation / Sleep Wake Disorders1
1CompletedNot AvailableHealthy Volunteers6
1CompletedDiagnosticHeart Diseases1
1CompletedPreventionHigh Blood Pressure (Hypertension)1
1CompletedTreatmentChronic Heart Failure (CHF) / Congestive Heart Failure (CHF)1
1CompletedTreatmentFasting State1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentHigh Blood Pressure (Hypertension)3
1WithdrawnTreatmentPulmonary Hypertension (PH)1
1, 2CompletedTreatmentPre-Hypertension1
1, 2CompletedTreatmentPulmonary Arterial Hypertension (PAH)1
1, 2WithdrawnTreatmentPulmonary Arterial Hypertension (PAH)1
2Active Not RecruitingPreventionCancer, Breast1
2Active Not RecruitingSupportive CareCancer Survivors1
2Active Not RecruitingSupportive CareCancer, Breast / Cardiac Toxicity1
2Active Not RecruitingTreatmentSmoking1
2CompletedTreatmentCocaine Withdrawal / Dependence, Cocaine1
2CompletedTreatmentCocaine-Related Disorders1
2Not Yet RecruitingTreatmentHypoglycemia Unawareness1
2RecruitingPreventionCancer Survivors / Heart Failure, Unspecified1
2RecruitingPreventionCardiovascular Abnormalities / HER2 Positive Breast Cancers1
2RecruitingPreventionCardiovascular Disease (CVD) / Diabetes Mellitus (DM) / High Blood Pressure (Hypertension)1
2RecruitingTreatmentProstate Cancer1
2RecruitingTreatmentPulmonary Arterial Hypertension (PAH)1
2TerminatedTreatmentCardiac MRI <40 / Pulmonary Hypertension (PH)1
2TerminatedTreatmentHigh Blood Pressure (Hypertension)1
2Unknown StatusTreatmentPost-Traumatic Stress Disorder (PTSD)1
2WithdrawnNot AvailableFeeling Anxious / Relapses / Substance Addiction1
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
3CompletedPreventionAutologous Hematopoietic Stem Cell Transplantation / Leukemia Acute Myeloid Leukemia (AML) / Lymphoid Neoplasms / Malignant Lymphomas / Multiple Myeloma (MM) / Precursor-cell Lymphoblastic Leukemia-Lymphoma1
3CompletedPreventionCancer, Breast / Cardiotoxicity / Heart Failure, Unspecified1
3CompletedPreventionLiver Cirrhosis / Portal Hypertension1
3CompletedTreatmentChronic Heart Failure (CHF)1
3CompletedTreatmentCongestive Heart Failure (CHF)3
3CompletedTreatmentHeart Failure, Unspecified1
3CompletedTreatmentHigh Blood Pressure (Hypertension)1
3CompletedTreatmentHigh Blood Pressure (Hypertension) / Obesity, Abdominal1
3CompletedTreatmentNonvalvular Atrial Fibrillation2
3RecruitingSupportive CareCardiotoxicity / HER2/Neu Positive / Metastatic Malignant Neoplasm in the Brain / Recurrent Breast Carcinoma / Stage IV Breast Cancer AJCC v6 and v71
3RecruitingTreatmentPortal Hypertension1
3TerminatedTreatmentHeart Failure, Unspecified / Nonvalvular Atrial Fibrillation1
3Unknown StatusTreatmentHypertension,Essential1
3WithdrawnTreatmentPortal Hypertension Related to Cirrhosis1
4CompletedBasic ScienceIdiopathic Dilated Cardiomyopathy1
4CompletedDiagnosticDiabetes Mellitus (DM)1
4CompletedDiagnosticHeart Failure, Unspecified / Prophylaxis of cardiomyopathy1
4CompletedPreventionAscites / Hepatic Encephalopathy / Portal Hypertension Gastropathy / Spontaneous Bacterial Peritonitis (SBP) / Varices, Esophageal1
4CompletedPreventionHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
4CompletedPreventionVariceal Rebleeding1
4CompletedTreatmentAdverse Effect of Beta-adrenoreceptor Antagonists / Asthma Bronchial / Pulmonary Disease, Chronic Obstructive1
4CompletedTreatmentAltitude / Arterial hypoxia / Heart Failure, Unspecified1
4CompletedTreatmentAlzheimer's Disease (AD)1
4CompletedTreatmentChronic Heart Failure (CHF)1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4CompletedTreatmentChronic Stable Angina Pectoris1
4CompletedTreatmentCoronary Artery Disease / High Blood Pressure (Hypertension)1
4CompletedTreatmentHeart Failure, Unspecified / Ventricular Dysfunction, Left1
4CompletedTreatmentHigh Blood Pressure (Hypertension)5
4CompletedTreatmentIntradialytic Hypertension1
4CompletedTreatmentMyocardial Infarction1
4Not Yet RecruitingTreatmentNonvalvular Atrial Fibrillation1
4Not Yet RecruitingTreatmentPortal Hypertension1
4RecruitingBasic ScienceAcute Coronary Syndromes (ACS)1
4RecruitingPreventionEsophageal and Gastric Varices / Hemorrhage / Liver Cirrhosis1
4RecruitingPreventionGastroesophageal Varices / Liver Cirrhosis1
4RecruitingPreventionLiver Cirrhosis / Portal Hypertension1
4RecruitingTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Hypertension,Essential / Strokes1
4RecruitingTreatmentCarvedilol / Outflow Tract / Ventricular Premature Complexes1
4RecruitingTreatmentEsophageal and Gastric Varices1
4RecruitingTreatmentEsophageal and Gastric Varices / Liver Cirrhosis1
4RecruitingTreatmentFontan / Univentricular heart1
4RecruitingTreatmentHeart Failure With Reduced Ejection Fraction (HFrEF)1
4RecruitingTreatmentHigh Blood Pressure (Hypertension)1
4RecruitingTreatmentLiver Cirrhosis / Portal Hypertension1
4TerminatedTreatmentHeart Failure, Unspecified1
4Unknown StatusNot AvailableDiabetes Mellitus (DM) / Endothelial Function / High Blood Pressure (Hypertension)1
4Unknown StatusPreventionBecker's Muscular Dystrophy (BMD) / Duchenne's Muscular Dystrophy (DMD)1
4Unknown StatusPreventionDuchenne's Muscular Dystrophy (DMD) / Prophylaxis of cardiomyopathy1
4Unknown StatusPreventionPortal Hypertension1
4Unknown StatusPreventionVariceal Bleeding1
4Unknown StatusTreatmentAnginal Pain / Coronary Heart Disease (CHD) / Hemodialysis-dependent patients1
4Unknown StatusTreatmentCongestive Cardiomyopathy1
4Unknown StatusTreatmentHigh Blood Pressure (Hypertension)1
4Unknown StatusTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
4WithdrawnTreatmentChronic Obstructive Pulmonary Disease (COPD) / Heart Failure, Unspecified1
Not AvailableCompletedNot AvailableAcute Myocardial Infarction (AMI) / Heart Failure, Unspecified1
Not AvailableCompletedNot AvailableHealthy Volunteers2
Not AvailableCompletedNot AvailableHigh Blood Pressure (Hypertension)1
Not AvailableCompletedBasic ScienceAmphetamine-Related Disorders / Moods Disorders / Substance-Related Disorders1
Not AvailableCompletedHealth Services ResearchDependence, Cocaine / Opiate Dependence1
Not AvailableCompletedPreventionDiabetes Mellitus (DM) / High Blood Pressure (Hypertension)1
Not AvailableCompletedPreventionLiver Cirrhosis1
Not AvailableCompletedTreatmentAcute on Chronic Liver Failure1
Not AvailableCompletedTreatmentArrythmias / Nonvalvular Atrial Fibrillation1
Not AvailableCompletedTreatmentChronic Liver Diseases (CLD) / Diastolic Dysfunction1
Not AvailableCompletedTreatmentCirrhosis With Esophageal Varices / Cirrhosis With Large Esophageal Varices1
Not AvailableCompletedTreatmentPulmonary Hypertension (PH)1
Not AvailableNot Yet RecruitingNot AvailableLiver Cirrhosis / Portal Hypertension1
Not AvailableRecruitingNot AvailableLiver Cirrhosis / Portal Hypertension / Varix, Esophageal1
Not AvailableRecruitingPreventionLiver Cirrhosis1
Not AvailableRecruitingTreatmentHeart Failure, Unspecified1
Not AvailableRecruitingTreatmentHigh Blood Pressure (Hypertension)1
Not AvailableRecruitingTreatmentLiver Cirrhosis1
Not AvailableRecruitingTreatmentNonvalvular Atrial Fibrillation1
Not AvailableUnknown StatusNot AvailableHeart Failure, Unspecified1
Not AvailableUnknown StatusTreatmentChronic Heart Failure (CHF)1
Not AvailableWithdrawnTreatmentHepatocellular Carcinoma With Portal Vein Thrombosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Actavis Group
  • Advantage Dose LLC
  • Amerisource Health Services Corp.
  • Apotex Inc.
  • A-S Medication Solutions LLC
  • Atlantic Biologicals Corporation
  • Aurobindo Pharma Ltd.
  • Bryant Ranch Prepack
  • Cadila Healthcare Ltd.
  • Caraco Pharmaceutical Labs
  • Cardinal Health
  • Caremark LLC
  • Dept Health Central Pharmacy
  • DHHS Program Support Center Supply Service Center
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Doctor Reddys Laboratories Ltd.
  • GlaxoSmithKline Inc.
  • Glenmark Generics Ltd.
  • Hikma Pharmaceuticals
  • Kaiser Foundation Hospital
  • Lupin Pharmaceuticals Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Ohm Laboratories Inc.
  • Patheon Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Prepak Systems Inc.
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Sandoz
  • Shasun Chemicals & Drugs Ltd.
  • Solco Healthcare US LLC
  • Southwood Pharmaceuticals
  • Taro Pharmaceuticals USA
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • Vangard Labs Inc.
  • West-Ward Pharmaceuticals
  • Zydus Pharmaceuticals
Dosage forms
FormRouteStrength
TabletOral12.5 mg/1
TabletOral25 mg/1
TabletOral25.0 mg
TabletOral3.125 mg/1
TabletOral6.25 mg/1
Tablet, film coatedOral12.5 mg/301
Tablet, film coatedOral12.5 mg/1
Tablet, film coatedOral25 mg/1
Tablet, film coatedOral3.125 mg/1
Tablet, film coatedOral6.25 mg/1
Capsule, extended releaseOral10 mg/1
Capsule, extended releaseOral20 mg/1
Capsule, extended releaseOral40 mg/1
Capsule, extended releaseOral80 mg/1
TabletOral50 mg
Kit
TabletOral12.5 mg
TabletOral25 mg
TabletOral3.125 mg
TabletOral6.25 mg
Prices
Unit descriptionCostUnit
Coreg CR 10 mg 24 Hour Capsule4.77USD capsule
Coreg CR 20 mg 24 Hour Capsule4.77USD capsule
Coreg CR 40 mg 24 Hour Capsule4.77USD capsule
Coreg CR 80 mg 24 Hour Capsule4.77USD capsule
Coreg cr 10 mg capsule4.59USD capsule
Coreg cr 20 mg capsule4.59USD capsule
Coreg cr 40 mg capsule4.59USD capsule
Coreg cr 80 mg capsule4.59USD capsule
Coreg 12.5 mg tablet2.54USD tablet
Coreg 25 mg tablet2.54USD tablet
Coreg 3.125 mg tablet2.54USD tablet
Coreg 6.25 mg tablet2.54USD tablet
Carvedilol 12.5 mg tablet2.18USD tablet
Carvedilol 25 mg tablet2.18USD tablet
Carvedilol 3.125 mg tablet2.18USD tablet
Carvedilol 6.25 mg tablet2.18USD tablet
Apo-Carvedilol 12.5 mg Tablet0.84USD tablet
Apo-Carvedilol 25 mg Tablet0.84USD tablet
Apo-Carvedilol 3.125 mg Tablet0.84USD tablet
Apo-Carvedilol 6.25 mg Tablet0.84USD tablet
Phl-Carvedilol 12.5 mg Tablet0.79USD tablet
Phl-Carvedilol 3.125 mg Tablet0.79USD tablet
Phl-Carvedilol 6.25 mg Tablet0.79USD tablet
Pms-Carvedilol 12.5 mg Tablet0.79USD tablet
Pms-Carvedilol 25 mg Tablet0.79USD tablet
Pms-Carvedilol 3.125 mg Tablet0.79USD tablet
Pms-Carvedilol 6.25 mg Tablet0.79USD tablet
Ran-Carvedilol 12.5 mg Tablet0.79USD tablet
Ran-Carvedilol 25 mg Tablet0.79USD tablet
Ran-Carvedilol 3.125 mg Tablet0.79USD tablet
Ran-Carvedilol 6.25 mg Tablet0.79USD tablet
Ratio-Carvedilol 12.5 mg Tablet0.79USD tablet
Ratio-Carvedilol 25 mg Tablet0.79USD tablet
Ratio-Carvedilol 3.125 mg Tablet0.79USD tablet
Ratio-Carvedilol 6.25 mg Tablet0.79USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7268156Yes2003-12-272023-12-27Us
US8101209Yes2006-03-112026-03-11Us
US6022562Yes1996-04-172016-04-17Us
USRE40000Yes1995-12-072015-12-07Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)114.5 °CPhysProp
water solubilityPractically insoluble (0.583 mg/L)Not Available
logP4.19AVDEEF,A (1997)
Predicted Properties
PropertyValueSource
Water Solubility0.00444 mg/mLALOGPS
logP3.05ALOGPS
logP3.42ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)14.03ChemAxon
pKa (Strongest Basic)8.74ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area75.74 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity115.64 m3·mol-1ChemAxon
Polarizability45.03 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9706
Blood Brain Barrier-0.6814
Caco-2 permeable-0.6308
P-glycoprotein substrateSubstrate0.8552
P-glycoprotein inhibitor INon-inhibitor0.8729
P-glycoprotein inhibitor IINon-inhibitor0.6521
Renal organic cation transporterNon-inhibitor0.5405
CYP450 2C9 substrateNon-substrate0.7517
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.5408
CYP450 1A2 substrateInhibitor0.524
CYP450 2C9 inhibitorNon-inhibitor0.8496
CYP450 2D6 inhibitorNon-inhibitor0.7274
CYP450 2C19 inhibitorNon-inhibitor0.5676
CYP450 3A4 inhibitorNon-inhibitor0.6352
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6048
Ames testNon AMES toxic0.8261
CarcinogenicityNon-carcinogens0.9692
BiodegradationNot ready biodegradable0.963
Rat acute toxicity2.4566 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5725
hERG inhibition (predictor II)Inhibitor0.8889
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-1662900000-f901a62f255da92e9a09
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-0220900000-5821022307fc5077033b

Taxonomy

Description
This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Indoles and derivatives
Sub Class
Carbazoles
Direct Parent
Carbazoles
Alternative Parents
Indoles / Phenoxy compounds / Methoxybenzenes / Anisoles / Alkyl aryl ethers / Pyrroles / Heteroaromatic compounds / Secondary alcohols / 1,2-aminoalcohols / Dialkylamines
show 3 more
Substituents
Carbazole / Indole / Phenoxy compound / Anisole / Phenol ether / Methoxybenzene / Alkyl aryl ether / Monocyclic benzene moiety / Benzenoid / Pyrrole
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
secondary alcohol, secondary amino compound, carbazoles (CHEBI:3441)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Receptor signaling protein activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately e...
Gene Name
ADRB1
Uniprot ID
P08588
Uniprot Name
Beta-1 adrenergic receptor
Molecular Weight
51322.1 Da
References
  1. Nichols AJ, Gellai M, Ruffolo RR Jr: Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol. Fundam Clin Pharmacol. 1991;5(1):25-38. [PubMed:1712335]
  2. Nichols AJ, Sulpizio AC, Ashton DJ, Hieble JP, Ruffolo RR Jr: In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol. Pharmacology. 1989;39(5):327-36. [PubMed:2575762]
  3. Nichols AJ, Sulpizio AC, Ashton DJ, Hieble JP, Ruffolo RR Jr: The interaction of the enantiomers of carvedilol with alpha 1- and beta 1-adrenoceptors. Chirality. 1989;1(4):265-70. [PubMed:2577144]
  4. de Mey C, Breithaupt K, Schloos J, Neugebauer G, Palm D, Belz GG: Dose-effect and pharmacokinetic-pharmacodynamic relationships of the beta 1-adrenergic receptor blocking properties of various doses of carvedilol in healthy humans. Clin Pharmacol Ther. 1994 Mar;55(3):329-37. [PubMed:7908256]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Protein heterodimerization activity
Specific Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) prot...
Gene Name
ADRA1A
Uniprot ID
P35348
Uniprot Name
Alpha-1A adrenergic receptor
Molecular Weight
51486.005 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons ...
Gene Name
NDUFC2
Uniprot ID
O95298
Uniprot Name
NADH dehydrogenase [ubiquinone] 1 subunit C2
Molecular Weight
14187.33 Da
References
  1. Oliveira PJ, Santos DJ, Moreno AJ: Carvedilol inhibits the exogenous NADH dehydrogenase in rat heart mitochondria. Arch Biochem Biophys. 2000 Feb 15;374(2):279-85. [PubMed:10666308]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Irodova NL, Krasnikova TL, Masenko VP, Kochetov AG, Chazova IE: [Carvedilol in treating primary pulmonary hypertension patients: effect on severity of cardiac failure, degree of pulmonary hypertension, concentration of catecholamines in blood plasma and dependence of cyclic AMP synthesis in lymphocytes on beta-adrenergic receptors]. Ter Arkh. 2002;74(8):30-4. [PubMed:12360591]
  2. Maebara C, Ohtani H, Sugahara H, Mine K, Kubo C, Sawada Y: Nightmares and panic disorder associated with carvedilol overdose. Ann Pharmacother. 2002 Nov;36(11):1736-40. [PubMed:12398570]
  3. Okajima K, Harada N, Uchiba M, Isobe H: Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats. J Pharmacol Exp Ther. 2004 May;309(2):684-91. Epub 2004 Feb 5. [PubMed:14764656]
  4. Nichols AJ, Gellai M, Ruffolo RR Jr: Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol. Fundam Clin Pharmacol. 1991;5(1):25-38. [PubMed:1712335]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other
General Function
Vascular endothelial growth factor receptor binding
Specific Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of...
Gene Name
VEGFA
Uniprot ID
P15692
Uniprot Name
Vascular endothelial growth factor A
Molecular Weight
27042.205 Da
References
  1. de Boer RA, Siebelink HJ, Tio RA, Boomsma F, van Veldhuisen DJ: Carvedilol increases plasma vascular endothelial growth factor (VEGF) in patients with chronic heart failure. Eur J Heart Fail. 2001 Jun;3(3):331-3. [PubMed:11378004]
  2. Saijonmaa O, Nyman T, Fyhrquist F: Carvedilol inhibits basal and stimulated ACE production in human endothelial cells. J Cardiovasc Pharmacol. 2004 May;43(5):616-21. [PubMed:15071347]
  3. Shyu KG, Lu MJ, Chang H, Sun HY, Wang BW, Kuan P: Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. J Card Fail. 2005 Mar;11(2):152-9. [PubMed:15732037]
  4. Shyu KG, Liou JY, Wang BW, Fang WJ, Chang H: Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart. J Biomed Sci. 2005;12(2):409-20. [PubMed:15942707]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other
General Function
Receptor binding
Specific Function
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition...
Gene Name
NPPB
Uniprot ID
P16860
Uniprot Name
Natriuretic peptides B
Molecular Weight
14725.825 Da
References
  1. Ohta Y, Watanabe K, Nakazawa M, Yamamoto T, Ma M, Fuse K, Ito M, Hirono S, Tanabe T, Hanawa H, Kato K, Kodama M, Aizawa Y: Carvedilol enhances atrial and brain natriuretic peptide mRNA expression and release in rat heart. J Cardiovasc Pharmacol. 2000;36 Suppl 2:S19-23. [PubMed:11206715]
  2. Richards AM, Doughty R, Nicholls MG, MacMahon S, Sharpe N, Murphy J, Espiner EA, Frampton C, Yandle TG: Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. Australia-New Zealand Heart Failure Group. J Am Coll Cardiol. 2001 Jun 1;37(7):1781-7. [PubMed:11401111]
  3. Konishi H, Nishio S, Tsutamoto T, Minouchi T, Yamaji A: Serum carvedilol concentration and its relation to change in plasma brain natriuretic peptide level in the treatment of heart failure: a preliminary study. Int J Clin Pharmacol Ther. 2003 Dec;41(12):578-86. [PubMed:14692707]
  4. Takeda Y, Fukutomi T, Suzuki S, Yamamoto K, Ogata M, Kondo H, Sugiura M, Shigeyama J, Itoh M: Effects of carvedilol on plasma B-type natriuretic peptide concentration and symptoms in patients with heart failure and preserved ejection fraction. Am J Cardiol. 2004 Aug 15;94(4):448-53. [PubMed:15325927]
  5. Frantz RP, Olson LJ, Grill D, Moualla SK, Nelson SM, Nobrega TP, Hanna RD, Backes RJ, Mookadam F, Heublein D, Bailey KR, Burnett JC: Carvedilol therapy is associated with a sustained decline in brain natriuretic peptide levels in patients with congestive heart failure. Am Heart J. 2005 Mar;149(3):541-7. [PubMed:15864245]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other
General Function
Signal transducer activity
Specific Function
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of ...
Gene Name
GJA1
Uniprot ID
P17302
Uniprot Name
Gap junction alpha-1 protein
Molecular Weight
43008.005 Da
References
  1. Yeh HI, Lee PY, Su CH, Tian TY, Ko YS, Tsai CH: Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens. 2006 Feb;19(2):129-35. [PubMed:16448880]
  2. Fan SY, Ke YN, Zeng YJ, Wang Y, Cheng WL, Yang JR: [Effects and the mechanism of carvedilol on gap junctional intercellular communication in rat myocardium]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1141-5. [PubMed:16563290]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the ...
Gene Name
KCNH2
Uniprot ID
Q12809
Uniprot Name
Potassium voltage-gated channel subfamily H member 2
Molecular Weight
126653.52 Da
References
  1. Karle CA, Kreye VA, Thomas D, Rockl K, Kathofer S, Zhang W, Kiehn J: Antiarrhythmic drug carvedilol inhibits HERG potassium channels. Cardiovasc Res. 2001 Feb 1;49(2):361-70. [PubMed:11164846]
  2. Kawakami K, Nagatomo T, Abe H, Kikuchi K, Takemasa H, Anson BD, Delisle BP, January CT, Nakashima Y: Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. [PubMed:16314852]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Primary amine oxidase activity
Specific Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and si...
Gene Name
VCAM1
Uniprot ID
P19320
Uniprot Name
Vascular cell adhesion protein 1
Molecular Weight
81275.43 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ: Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2075-81. Epub 2004 Sep 16. [PubMed:15374848]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Alpha1-adrenergic receptor activity
Specific Function
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Gene Name
ADRA1D
Uniprot ID
P25100
Uniprot Name
Alpha-1D adrenergic receptor
Molecular Weight
60462.205 Da
References
  1. Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A: Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res. 2004 Sep 1;63(4):662-72. [PubMed:15306222]
  2. Van Tassell BW, Rondina MT, Huggins F, Gilbert EM, Munger MA: Carvedilol increases blood pressure response to phenylephrine infusion in heart failure subjects with systolic dysfunction: evidence of improved vascular alpha1-adrenoreceptor signal transduction. Am Heart J. 2008 Aug;156(2):315-21. doi: 10.1016/j.ahj.2008.04.004. Epub 2008 Jun 20. [PubMed:18657662]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Protein heterodimerization activity
Specific Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) prot...
Gene Name
ADRA1B
Uniprot ID
P35368
Uniprot Name
Alpha-1B adrenergic receptor
Molecular Weight
56835.375 Da
References
  1. Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A: Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res. 2004 Sep 1;63(4):662-72. [PubMed:15306222]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Protein homodimerization activity
Specific Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name
ADRA2C
Uniprot ID
P18825
Uniprot Name
Alpha-2C adrenergic receptor
Molecular Weight
49521.585 Da
References
  1. Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A: Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res. 2004 Sep 1;63(4):662-72. [PubMed:15306222]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Epinephrine binding
Specific Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine...
Gene Name
ADRA2B
Uniprot ID
P18089
Uniprot Name
Alpha-2B adrenergic receptor
Molecular Weight
49565.8 Da
References
  1. Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A: Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res. 2004 Sep 1;63(4):662-72. [PubMed:15306222]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Thioesterase binding
Specific Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazo...
Gene Name
ADRA2A
Uniprot ID
P08913
Uniprot Name
Alpha-2A adrenergic receptor
Molecular Weight
48956.275 Da
References
  1. Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A: Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res. 2004 Sep 1;63(4):662-72. [PubMed:15306222]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Transmembrane signaling receptor activity
Specific Function
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in ...
Gene Name
SELE
Uniprot ID
P16581
Uniprot Name
E-selectin
Molecular Weight
66654.575 Da
References
  1. Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ: Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2075-81. Epub 2004 Sep 16. [PubMed:15374848]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Modulator
General Function
Ubiquitin protein ligase binding
Specific Function
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transp...
Gene Name
HIF1A
Uniprot ID
Q16665
Uniprot Name
Hypoxia-inducible factor 1-alpha
Molecular Weight
92669.595 Da
References
  1. Shyu KG, Lu MJ, Chang H, Sun HY, Wang BW, Kuan P: Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. J Card Fail. 2005 Mar;11(2):152-9. [PubMed:15732037]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Pdz domain binding
Specific Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentratio...
Gene Name
KCNJ4
Uniprot ID
P48050
Uniprot Name
Inward rectifier potassium channel 4
Molecular Weight
49499.61 Da
References
  1. Ferrer T, Ponce-Balbuena D, Lopez-Izquierdo A, Arechiga-Figueroa IA, de Boer TP, van der Heyden MA, Sanchez-Chapula JA: Carvedilol inhibits Kir2.3 channels by interference with PIP(2)-channel interaction. Eur J Pharmacol. 2011 Oct 1;668(1-2):72-7. doi: 10.1016/j.ejphar.2011.05.067. Epub 2011 Jun 6. [PubMed:21663737]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Xanthine oxidase activity
Specific Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Ha...
Gene Name
XDH
Uniprot ID
P47989
Uniprot Name
Xanthine dehydrogenase/oxidase
Molecular Weight
146422.99 Da
References
  1. Yue TL, McKenna PJ, Gu JL, Cheng HY, Ruffolo RE Jr, Feuerstein GZ: Carvedilol, a new vasodilating beta adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils. Cardiovasc Res. 1994 Mar;28(3):400-6. [PubMed:7909721]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Steroid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
Gene Name
UGT1A1
Uniprot ID
P22309
Uniprot Name
UDP-glucuronosyltransferase 1-1
Molecular Weight
59590.91 Da
References
  1. Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE: Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. doi: 10.1124/dmd.104.000794. Epub 2004 Aug 10. [PubMed:15304429]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514]
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Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:49