Catechol O-methyltransferase
Details
- Name
- Catechol O-methyltransferase
- Synonyms
- 2.1.1.6
- Gene Name
- COMT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004096|Catechol O-methyltransferase MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
- Number of residues
- 271
- Molecular Weight
- 30036.77
- Theoretical pI
- 5.15
- GO Classification
- Functionscatechol O-methyltransferase activity / magnesium ion binding / O-methyltransferase activityProcessescellular response to phosphate starvation / developmental process / dopamine catabolic process / estrogen metabolic process / female pregnancy / learning / methylation / multicellular organismal reproductive process / negative regulation of dopamine metabolic process / negative regulation of renal sodium excretion / negative regulation of smooth muscle cell proliferation / neurotransmitter biosynthetic process / neurotransmitter catabolic process / positive regulation of homocysteine metabolic process / regulation of sensory perception of pain / response to drug / response to lipopolysaccharide / response to organic cyclic compound / response to pain / short-term memory / small molecule metabolic process / synaptic transmission / xenobiotic metabolic processComponentsaxon / cell body / cytosol / dendritic spine / extracellular exosome / integral component of membrane / membrane / mitochondrion / plasma membrane / postsynaptic membrane
- General Function
- O-methyltransferase activity
- Specific Function
- Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
- Pfam Domain Function
- Methyltransf_3 (PF01596)
- Transmembrane Regions
- 7-26
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011516|Catechol O-methyltransferase (COMT) ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA
- Chromosome Location
- 22
- Locus
- 22q11.21-q11.23|22q11.21
- External Identifiers
Resource Link UniProtKB ID P21964 UniProtKB Entry Name COMT_HUMAN GenBank Protein ID 180920 GenBank Gene ID M65212 GenAtlas ID COMT HGNC ID HGNC:2228 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02105 3,5-Dinitrocatechol experimental unknown Details DB03907 N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide experimental unknown Details DB00323 Tolcapone approved, withdrawn yes inhibitor Details DB00494 Entacapone approved, investigational yes inhibitor Details DB00494 Entacapone approved, investigational unknown inhibitor Details DB00255 Diethylstilbestrol approved, investigational, withdrawn unknown substrate Details DB00286 Conjugated estrogens approved unknown substrate Details DB00841 Dobutamine approved unknown substrate Details DB00968 Methyldopa approved no substrate Details DB00988 Dopamine approved unknown substrate Details DB01141 Micafungin approved, investigational unknown substrate Details DB03336 BIA experimental unknown Details DB07462 (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE experimental unknown Details DB08049 7,8-dihydroxy-4-phenyl-2H-chromen-2-one experimental unknown Details DB00118 Ademetionine approved, investigational, nutraceutical unknown cofactor Details DB04820 Nialamide approved, withdrawn unknown Details DB02342 2-Methoxyestradiol investigational unknown Details DB06152 Nylidrin approved unknown inducer Details DB01420 Testosterone propionate approved, investigational, vet_approved, withdrawn unknown inhibitor Details DB11632 Opicapone approved, investigational yes inhibitor Details DB00668 Epinephrine approved, vet_approved no substrate Details DB15488 Echinacoside experimental unknown substrate Details DB00252 Phenytoin approved, vet_approved no substrate Details DB00783 Estradiol approved, investigational, vet_approved unknown substrate Details DB00977 Ethinylestradiol approved unknown substrate Details DB00714 Apomorphine approved, investigational unknown substrate Details DB01064 Isoprenaline approved, investigational unknown substrate Details