Identification

Name
Testosterone propionate
Accession Number
DB01420  (DBSALT001032)
Type
Small Molecule
Groups
Approved, Investigational, Vet approved, Withdrawn
Description

Testosterone propionate is a slower releasing anabolic steroid with a short half-life. This characteristic allows the user to run short testosterone propionate cycles of 8-10 weeks as optimal peak blood plasma levels are achieved at 2-4 weeks.[4] It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.[2] Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.[5]

Structure
Thumb
Synonyms
Not Available
External IDs
NRB-03689 / NSC-9166
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Malogen In Oil Liq 100mg/mlLiquid100 mgIntramuscularGermiphene Corporation1995-12-311999-04-14Canada
Testosterone Propionate Inj 100mg/mlLiquid100 mgIntramuscularTaro Pharmaceuticals, Inc.1972-12-312001-08-21Canada
Testosterone Propionate Injection, USPLiquid100 mgIntramuscularSterimax Inc1992-12-31Not applicableCanada
International/Other Brands
Testex
Categories
UNII
WI93Z9138A
CAS number
57-85-2
Weight
Average: 344.4877
Monoisotopic: 344.23514489
Chemical Formula
C22H32O3
InChI Key
PDMMFKSKQVNJMI-BLQWBTBKSA-N
InChI
InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
IUPAC Name
(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl propanoate
SMILES
[H][C@@]12CC[C@H](OC(=O)CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Pharmacology

Indication

Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause.[6] Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.[5]

Pharmacodynamics

The administration of testosterone propionate can induce production of proteins related to male sexual development.[7] On the other hand, testosterone itself present an estrogenic activity due to interaction with aromatase enzyme, thus the continuous aministration of testosterone propionate may cause the elevation of plasma estrogen.[6] Clinical trials showed as well, a decrease in plasma LH after testosterone propionate administration.[1]

Mechanism of action

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

TargetActionsOrganism
AAndrogen receptor
agonist
Human
Absorption

Testosterone propionate presents a slow absorption from the intramuscular site of administration. This slow absorption is due to the presence of the less polar ester group.[7] The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.[1]

Volume of distribution

The registered volume of distribution for testosterone propionate is in the range of 75-120 L/kg.[1]

Protein binding

Even 98% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound or bound to albumin and other proteins.[3]

Metabolism

As all testosterone esters, testosterone propionate is rapidly hydrolysed into free testosterone in plasma.[1] Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).[7]

Route of elimination

About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites. From the rest of the dose, approximately 6% of a dose is excreted in the feces, mostly in the unconjugated form.[7]

Half life

Testosterone propionate presents a the shortest half life of all testosterone esters, being of 4.5 days. This characteristic produces a higher administration requirement.[4]

Clearance

Testosterone propionate has a reduced clearance rate compared to testosterone.[7] The reported clearance rate is of approximately 2000 ml/min.[1]

Toxicity

Reports have showed a potential stimulation of cancerous tissue growth. The potential testosterone propionate accumulation in the body produces a high risk of edema secondaryh to water and sodium retention.[7]

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the fluid retaining activities of Testosterone propionate.Investigational
19-norandrostenedione19-norandrostenedione may increase the fluid retaining activities of Testosterone propionate.Experimental, Illicit
5-androstenedione5-androstenedione may increase the fluid retaining activities of Testosterone propionate.Experimental, Illicit
AcarboseTestosterone propionate may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcenocoumarolTestosterone propionate may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Testosterone propionate.Approved
Acetyl sulfisoxazoleThe metabolism of Testosterone propionate can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AlbiglutideTestosterone propionate may increase the hypoglycemic activities of Albiglutide.Approved
AlclometasoneAlclometasone may increase the fluid retaining activities of Testosterone propionate.Approved
AldosteroneAldosterone may increase the fluid retaining activities of Testosterone propionate.Experimental, Investigational
AlogliptinTestosterone propionate may increase the hypoglycemic activities of Alogliptin.Approved
AmcinonideAmcinonide may increase the fluid retaining activities of Testosterone propionate.Approved
AmiodaroneThe serum concentration of Testosterone propionate can be increased when it is combined with Amiodarone.Approved, Investigational
AmlodipineThe serum concentration of Testosterone propionate can be increased when it is combined with Amlodipine.Approved
AndrostenedioneAndrostenedione may increase the fluid retaining activities of Testosterone propionate.Experimental, Illicit
AnecortaveAnecortave may increase the fluid retaining activities of Testosterone propionate.Investigational
anecortave acetateanecortave acetate may increase the fluid retaining activities of Testosterone propionate.Investigational
ApalutamideThe serum concentration of Testosterone propionate can be decreased when it is combined with Apalutamide.Approved, Investigational
AprepitantThe serum concentration of Testosterone propionate can be increased when it is combined with Aprepitant.Approved, Investigational
AtamestaneAtamestane may increase the fluid retaining activities of Testosterone propionate.Investigational
AtazanavirThe metabolism of Testosterone propionate can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Testosterone propionate can be decreased when combined with Atomoxetine.Approved
Beclomethasone dipropionateThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Beclomethasone dipropionate.Approved, Investigational
Benzyl alcoholThe serum concentration of Testosterone propionate can be increased when it is combined with Benzyl alcohol.Approved
BepridilThe serum concentration of Testosterone propionate can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneBetamethasone may increase the fluid retaining activities of Testosterone propionate.Approved, Vet Approved
BoceprevirThe metabolism of Testosterone propionate can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Testosterone propionate can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Testosterone propionate can be decreased when it is combined with Bosentan.Approved, Investigational
BromocriptineTestosterone propionate may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BudesonideThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Budesonide.Approved
CaffeineThe serum concentration of Testosterone propionate can be increased when it is combined with Caffeine.Approved
CanagliflozinTestosterone propionate may increase the hypoglycemic activities of Canagliflozin.Approved
CarbamazepineThe metabolism of Testosterone propionate can be increased when combined with Carbamazepine.Approved, Investigational
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Testosterone propionate.Approved, Investigational
CeritinibThe serum concentration of Testosterone propionate can be increased when it is combined with Ceritinib.Approved
ChlorpropamideTestosterone propionate may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
CiclesonideCiclesonide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
ClarithromycinThe metabolism of Testosterone propionate can be decreased when combined with Clarithromycin.Approved
ClobetasolClobetasol may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
Clobetasol propionateClobetasol propionate may increase the fluid retaining activities of Testosterone propionate.Approved
ClobetasoneClobetasone may increase the fluid retaining activities of Testosterone propionate.Approved
ClocortoloneClocortolone may increase the fluid retaining activities of Testosterone propionate.Approved
ClorindioneTestosterone propionate may increase the anticoagulant activities of Clorindione.Experimental
ClotrimazoleThe metabolism of Testosterone propionate can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe metabolism of Testosterone propionate can be decreased when combined with Cobicistat.Approved
CodeineThe serum concentration of Codeine can be decreased when it is combined with Testosterone propionate.Approved, Illicit
Conestat alfaTestosterone propionate may increase the thrombogenic activities of Conestat alfa.Approved, Investigational
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Testosterone propionate.Approved, Investigational
Cortexolone 17α-propionateCortexolone 17α-propionate may increase the fluid retaining activities of Testosterone propionate.Investigational
CorticosteroneCorticosterone may increase the fluid retaining activities of Testosterone propionate.Experimental
Cortisone acetateCortisone acetate may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
CrizotinibThe metabolism of Testosterone propionate can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Testosterone propionate can be decreased when combined with Curcumin.Approved, Investigational
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Testosterone propionate.Approved
CyclosporineTestosterone propionate may increase the hepatotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Testosterone propionate can be decreased when it is combined with Dabrafenib.Approved, Investigational
DapagliflozinTestosterone propionate may increase the hypoglycemic activities of Dapagliflozin.Approved
DarunavirThe metabolism of Testosterone propionate can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Testosterone propionate can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Testosterone propionate can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortDeflazacort may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
DelavirdineThe metabolism of Testosterone propionate can be decreased when combined with Delavirdine.Approved
DesonideDesonide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
DesoximetasoneDesoximetasone may increase the fluid retaining activities of Testosterone propionate.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the fluid retaining activities of Testosterone propionate.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may increase the fluid retaining activities of Testosterone propionate.Experimental, Vet Approved
DexamethasoneThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the fluid retaining activities of Testosterone propionate.Vet Approved
DexniguldipineThe serum concentration of Testosterone propionate can be increased when it is combined with Dexniguldipine.Experimental
Dextrose, unspecified formThe serum concentration of Dextrose, unspecified form can be decreased when it is combined with Testosterone propionate.Approved, Vet Approved
DexverapamilThe serum concentration of Testosterone propionate can be increased when it is combined with Dexverapamil.Experimental
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Testosterone propionate.Approved, Vet Approved
DicoumarolTestosterone propionate may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneDiflorasone may increase the fluid retaining activities of Testosterone propionate.Approved
DifluocortoloneDifluocortolone may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Withdrawn
DifluprednateDifluprednate may increase the fluid retaining activities of Testosterone propionate.Approved
DihydroergotamineThe metabolism of Testosterone propionate can be decreased when combined with Dihydroergotamine.Approved, Investigational
DiltiazemThe metabolism of Testosterone propionate can be decreased when combined with Diltiazem.Approved, Investigational
DiphenadioneTestosterone propionate may increase the anticoagulant activities of Diphenadione.Experimental
DisopyramideTestosterone propionate may increase the hypoglycemic activities of Disopyramide.Approved
DoxazosinThe serum concentration of Testosterone propionate can be increased when it is combined with Doxazosin.Approved
DoxycyclineThe metabolism of Testosterone propionate can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Testosterone propionate can be decreased when combined with Dronedarone.Approved
DulaglutideTestosterone propionate may increase the hypoglycemic activities of Dulaglutide.Approved, Investigational
EmopamilThe serum concentration of Testosterone propionate can be increased when it is combined with Emopamil.Experimental
EmpagliflozinTestosterone propionate may increase the hypoglycemic activities of Empagliflozin.Approved
EnzalutamideThe serum concentration of Testosterone propionate can be decreased when it is combined with Enzalutamide.Approved
EquileninEquilenin may increase the fluid retaining activities of Testosterone propionate.Experimental
EquilinEquilin may increase the fluid retaining activities of Testosterone propionate.Approved
ErythromycinThe metabolism of Testosterone propionate can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Testosterone propionate.Approved, Investigational, Vet Approved
EstroneEstrone may increase the fluid retaining activities of Testosterone propionate.Approved
Estrone sulfateEstrone sulfate may increase the fluid retaining activities of Testosterone propionate.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Testosterone propionate.Approved
Ethyl biscoumacetateTestosterone propionate may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
ExenatideTestosterone propionate may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipineThe serum concentration of Testosterone propionate can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Testosterone propionate can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FluasteroneFluasterone may increase the fluid retaining activities of Testosterone propionate.Investigational
FluconazoleThe metabolism of Testosterone propionate can be decreased when combined with Fluconazole.Approved, Investigational
FludrocortisoneFludrocortisone may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
FluindioneTestosterone propionate may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneFlumethasone may increase the fluid retaining activities of Testosterone propionate.Approved, Vet Approved
FlunisolideFlunisolide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
Fluocinolone AcetonideFluocinolone Acetonide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
FluocortoloneFluocortolone may increase the fluid retaining activities of Testosterone propionate.Approved, Withdrawn
FluorometholoneFluorometholone may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
FluoxetineThe serum concentration of Testosterone propionate can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FluprednideneFluprednidene may increase the fluid retaining activities of Testosterone propionate.Approved, Withdrawn
FluprednisoloneFluprednisolone may increase the fluid retaining activities of Testosterone propionate.Approved
FlurandrenolideFlurandrenolide may increase the fluid retaining activities of Testosterone propionate.Approved
FluticasoneFluticasone may increase the fluid retaining activities of Testosterone propionate.Approved, Experimental, Investigational
Fluticasone furoateFluticasone furoate may increase the fluid retaining activities of Testosterone propionate.Approved
Fluticasone propionateThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Fluticasone propionate.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Testosterone propionate.Approved
FluvoxamineThe serum concentration of Testosterone propionate can be increased when it is combined with Fluvoxamine.Approved, Investigational
FormestaneFormestane may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Withdrawn
FosamprenavirThe metabolism of Testosterone propionate can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Testosterone propionate can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Testosterone propionate can be increased when combined with Fosphenytoin.Approved, Investigational
FurosemideThe serum concentration of Furosemide can be decreased when it is combined with Testosterone propionate.Approved, Vet Approved
Fusidic AcidThe serum concentration of Testosterone propionate can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabexateTestosterone propionate may increase the thrombogenic activities of Gabexate.Investigational
GallopamilThe serum concentration of Testosterone propionate can be increased when it is combined with Gallopamil.Investigational
GliclazideTestosterone propionate may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideTestosterone propionate may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Testosterone propionate.Approved, Investigational
GlyburideThe serum concentration of Testosterone propionate can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Testosterone propionate can be increased when it is combined with Glycerin.Approved, Investigational
HalcinonideHalcinonide may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Withdrawn
HE3286HE3286 may increase the fluid retaining activities of Testosterone propionate.Investigational
Human C1-esterase inhibitorTestosterone propionate may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HydrocortisoneThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Hydrocortisone.Approved, Vet Approved
Hydrocortisone acetateThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Hydrocortisone acetate.Approved, Vet Approved
Hydrocortisone butyrateThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Hydrocortisone butyrate.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Testosterone propionate.Approved
IdelalisibThe metabolism of Testosterone propionate can be decreased when combined with Idelalisib.Approved
ImatinibThe metabolism of Testosterone propionate can be decreased when combined with Imatinib.Approved
IndinavirThe metabolism of Testosterone propionate can be decreased when combined with Indinavir.Approved
Insulin AspartTestosterone propionate may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirTestosterone propionate may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineTestosterone propionate may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineTestosterone propionate may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanTestosterone propionate may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproTestosterone propionate may increase the hypoglycemic activities of Insulin Lispro.Approved
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Testosterone propionate.Approved, Investigational
IsavuconazoleThe serum concentration of Testosterone propionate can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Testosterone propionate can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe serum concentration of Testosterone propionate can be increased when it is combined with Isradipine.Approved, Investigational
IstaroximeIstaroxime may increase the fluid retaining activities of Testosterone propionate.Investigational
ItraconazoleThe metabolism of Testosterone propionate can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Testosterone propionate can be increased when it is combined with Ivacaftor.Approved
KetoconazoleThe metabolism of Testosterone propionate can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Testosterone propionate.Approved, Investigational
LidocaineThe serum concentration of Testosterone propionate can be increased when it is combined with Lidocaine.Approved, Vet Approved
LiraglutideTestosterone propionate may increase the hypoglycemic activities of Liraglutide.Approved
LomerizineThe serum concentration of Testosterone propionate can be increased when it is combined with Lomerizine.Experimental
LoperamideThe serum concentration of Testosterone propionate can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Testosterone propionate can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Testosterone propionate can be increased when it is combined with Loratadine.Approved, Investigational
LorpiprazoleThe serum concentration of Testosterone propionate can be increased when it is combined with Lorpiprazole.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Testosterone propionate.Approved
LoteprednolLoteprednol may increase the fluid retaining activities of Testosterone propionate.Approved
LovastatinThe metabolism of Testosterone propionate can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Testosterone propionate can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Testosterone propionate can be decreased when it is combined with Lumacaftor.Approved
ME-609ME-609 may increase the fluid retaining activities of Testosterone propionate.Investigational
MecaserminTestosterone propionate may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MedrysoneMedrysone may increase the fluid retaining activities of Testosterone propionate.Approved
MelengestrolMelengestrol may increase the fluid retaining activities of Testosterone propionate.Vet Approved
MetforminTestosterone propionate may increase the hypoglycemic activities of Metformin.Approved
MethylprednisoloneThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Methylprednisolone.Approved, Vet Approved
MibefradilThe metabolism of Testosterone propionate can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Testosterone propionate can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MifepristoneThe serum concentration of Testosterone propionate can be increased when it is combined with Mifepristone.Approved, Investigational
MiglitolTestosterone propionate may increase the hypoglycemic activities of Miglitol.Approved
MitotaneThe serum concentration of Testosterone propionate can be decreased when it is combined with Mitotane.Approved
MometasoneMometasone may increase the fluid retaining activities of Testosterone propionate.Approved, Vet Approved
NaproxenThe serum concentration of Naproxen can be decreased when it is combined with Testosterone propionate.Approved, Vet Approved
NateglinideTestosterone propionate may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 1022NCX 1022 may increase the fluid retaining activities of Testosterone propionate.Investigational
NefazodoneThe metabolism of Testosterone propionate can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Testosterone propionate can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Testosterone propionate can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Testosterone propionate can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Testosterone propionate can be increased when it is combined with Nicardipine.Approved, Investigational
NiguldipineThe serum concentration of Testosterone propionate can be increased when it is combined with Niguldipine.Experimental
NilotinibThe metabolism of Testosterone propionate can be decreased when combined with Nilotinib.Approved, Investigational
NimodipineThe serum concentration of Testosterone propionate can be increased when it is combined with Nimodipine.Approved, Investigational
NisoldipineThe serum concentration of Testosterone propionate can be increased when it is combined with Nisoldipine.Approved
NitrendipineThe serum concentration of Testosterone propionate can be increased when it is combined with Nitrendipine.Approved, Investigational
OlaparibThe metabolism of Testosterone propionate can be decreased when combined with Olaparib.Approved
Oleoyl-estroneOleoyl-estrone may increase the fluid retaining activities of Testosterone propionate.Investigational
OmeprazoleThe serum concentration of Testosterone propionate can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Testosterone propionate can be increased when it is combined with Osimertinib.Approved
PalbociclibThe serum concentration of Testosterone propionate can be increased when it is combined with Palbociclib.Approved, Investigational
ParamethasoneParamethasone may increase the fluid retaining activities of Testosterone propionate.Approved
ParoxetineThe serum concentration of Testosterone propionate can be increased when it is combined with Paroxetine.Approved, Investigational
PentamidineTestosterone propionate may increase the hypoglycemic activities of Pentamidine.Approved, Investigational
PentobarbitalThe metabolism of Testosterone propionate can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PhenindioneTestosterone propionate may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe metabolism of Testosterone propionate can be increased when combined with Phenobarbital.Approved, Investigational
PhenprocoumonTestosterone propionate may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenytoinThe metabolism of Testosterone propionate can be increased when combined with Phenytoin.Approved, Vet Approved
PioglitazoneTestosterone propionate may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PitolisantThe serum concentration of Testosterone propionate can be decreased when it is combined with Pitolisant.Approved, Investigational
PosaconazoleThe metabolism of Testosterone propionate can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramlintideTestosterone propionate may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrasteronePrasterone may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Nutraceutical
Prasterone sulfatePrasterone sulfate may increase the fluid retaining activities of Testosterone propionate.Investigational
PrednicarbatePrednicarbate may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational
PrednisoloneThe risk or severity of edema formation can be increased when Testosterone propionate is combined with Prednisolone.Approved, Vet Approved
PrednisonePrednisone may increase the fluid retaining activities of Testosterone propionate.Approved, Vet Approved
PregnenolonePregnenolone may increase the fluid retaining activities of Testosterone propionate.Approved, Experimental, Investigational
PrimidoneThe metabolism of Testosterone propionate can be increased when combined with Primidone.Approved, Vet Approved
PromethazineThe serum concentration of Testosterone propionate can be increased when it is combined with Promethazine.Approved, Investigational
PropafenoneThe serum concentration of Testosterone propionate can be increased when it is combined with Propafenone.Approved
QuinineTestosterone propionate may increase the hypoglycemic activities of Quinine.Approved
RanitidineThe serum concentration of Testosterone propionate can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Testosterone propionate can be increased when it is combined with Ranolazine.Approved, Investigational
RepaglinideTestosterone propionate may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RifabutinThe metabolism of Testosterone propionate can be increased when combined with Rifabutin.Approved, Investigational
RifampicinThe metabolism of Testosterone propionate can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Testosterone propionate can be increased when combined with Rifapentine.Approved, Investigational
RimexoloneRimexolone may increase the fluid retaining activities of Testosterone propionate.Approved
RosiglitazoneTestosterone propionate may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
RucaparibThe metabolism of Testosterone propionate can be decreased when combined with Rucaparib.Approved, Investigational
SaquinavirThe metabolism of Testosterone propionate can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Testosterone propionate can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinTestosterone propionate may increase the hypoglycemic activities of Saxagliptin.Approved
SildenafilThe metabolism of Testosterone propionate can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Testosterone propionate can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Testosterone propionate can be increased when it is combined with Simeprevir.Approved
SitagliptinTestosterone propionate may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
St. John's WortThe serum concentration of Testosterone propionate can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Testosterone propionate can be increased when it is combined with Stiripentol.Approved
SulfadiazineTestosterone propionate may increase the hypoglycemic activities of Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleTestosterone propionate may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Testosterone propionate can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibTestosterone propionate may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TelaprevirThe metabolism of Testosterone propionate can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Testosterone propionate can be decreased when combined with Telithromycin.Approved
TetrandrineThe serum concentration of Testosterone propionate can be increased when it is combined with Tetrandrine.Experimental
TiclopidineThe metabolism of Testosterone propionate can be decreased when combined with Ticlopidine.Approved
TioclomarolTestosterone propionate may increase the anticoagulant activities of Tioclomarol.Experimental
TixocortolTixocortol may increase the fluid retaining activities of Testosterone propionate.Approved, Withdrawn
TocilizumabThe serum concentration of Testosterone propionate can be decreased when it is combined with Tocilizumab.Approved
TolazamideTestosterone propionate may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolbutamideTestosterone propionate may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Testosterone propionate.Approved, Investigational
TriamcinoloneTriamcinolone may increase the fluid retaining activities of Testosterone propionate.Approved, Vet Approved
UlobetasolUlobetasol may increase the fluid retaining activities of Testosterone propionate.Approved
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Testosterone propionate.Approved, Investigational
VemurafenibThe serum concentration of Testosterone propionate can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe serum concentration of Testosterone propionate can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Testosterone propionate can be increased when it is combined with Verapamil.Approved
VoriconazoleThe metabolism of Testosterone propionate can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinTestosterone propionate may increase the anticoagulant activities of Warfarin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Testosterone propionate.Approved
ZiprasidoneThe metabolism of Testosterone propionate can be decreased when combined with Ziprasidone.Approved
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Testosterone propionate.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Fujioka M, Shinohara Y, Baba S, Irie M, Inoue K: Pharmacokinetic properties of testosterone propionate in normal men. J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4. doi: 10.1210/jcem-63-6-1361. [PubMed:3782423]
  2. Elks J. and Ganellin C.R. (1990). The dictionary of drugs. Springer Science.
  3. Woo T.M. and Robinson M. (2016). Pharmacotherapeutics for advanced practice nurse prescribers (4th ed.). Davis Company.
  4. Steroidal [Link]
  5. Dailymed [Link]
  6. Steroidal [Link]
  7. Empowerpharmacy [Link]
  8. Fittness uncovered [Link]
External Links
Human Metabolome Database
HMDB0015489
KEGG Drug
D00959
KEGG Compound
C08158
PubChem Compound
5995
PubChem Substance
46508693
ChemSpider
5774
BindingDB
50215709
ChEBI
9466
ChEMBL
CHEMBL1170
PharmGKB
PA164751373
Drugs.com
Drugs.com Drug Page
Wikipedia
Testosterone_propionate
AHFS Codes
  • 68:08.00 — Androgens
MSDS
Download (50 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2SuspendedTreatmentNeoplasms, Breast / Painful Intercourse / Vaginal Inflammation1
Not AvailableCompletedBasic ScienceFeeling Anxious1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • C.O. Truxton Inc.
  • Cutis Pharma Inc.
  • Dispensing Solutions
  • Lyne Laboratories Inc.
  • Paddock Labs
  • Wa Butler Co.
Dosage forms
FormRouteStrength
LiquidIntramuscular100 mg
Prices
Unit descriptionCostUnit
Testosterone propionate powder6.25USD g
First-testosterone mc 2% cr0.91USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)118-123 °CElks. The Dictionary of Drugs. (1990)
water solubility1.48 mg/L (at 25ºC)Yalkowsky, SH & Dannenfelser, RM. (1992)
logS-5.37ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.00502 mg/mLALOGPS
logP3.65ALOGPS
logP4.51ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)19.09ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area43.37 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity98.21 m3·mol-1ChemAxon
Polarizability40.43 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.974
Caco-2 permeable+0.6304
P-glycoprotein substrateSubstrate0.6262
P-glycoprotein inhibitor IInhibitor0.8746
P-glycoprotein inhibitor IIInhibitor0.7623
Renal organic cation transporterNon-inhibitor0.776
CYP450 2C9 substrateNon-substrate0.8672
CYP450 2D6 substrateNon-substrate0.9159
CYP450 3A4 substrateSubstrate0.7429
CYP450 1A2 substrateNon-inhibitor0.9445
CYP450 2C9 inhibitorNon-inhibitor0.8459
CYP450 2D6 inhibitorNon-inhibitor0.9301
CYP450 2C19 inhibitorInhibitor0.6089
CYP450 3A4 inhibitorNon-inhibitor0.7576
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5939
Ames testNon AMES toxic0.9474
CarcinogenicityNon-carcinogens0.9046
BiodegradationNot ready biodegradable0.9777
Rat acute toxicity2.0463 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8475
hERG inhibition (predictor II)Non-inhibitor0.7643
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (9.53 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0a4i-9800000000-8aff9c2cbe0b5c20d85a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Steroid esters
Direct Parent
Steroid esters
Alternative Parents
Androgens and derivatives / 3-oxo delta-4-steroids / Delta-4-steroids / Cyclohexenones / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives
Substituents
Steroid ester / Androgen-skeleton / Androstane-skeleton / 3-oxosteroid / 3-oxo-delta-4-steroid / Oxosteroid / Delta-4-steroid / Cyclohexenone / Ketone / Carboxylic acid ester
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
steroid ester (CHEBI:9466) / C19 steroids (androgens) and derivatives (C08158) / C19 steroids (androgens) and derivatives (LMST02020076)

Targets

Details
1. Androgen receptor
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
Gene Name
AR
Uniprot ID
P10275
Uniprot Name
Androgen receptor
Molecular Weight
98987.9 Da
References
  1. Small EJ, Ryan CJ: The case for secondary hormonal therapies in the chemotherapy age. J Urol. 2006 Dec;176(6 Pt 2):S66-71. [PubMed:17084172]
  2. Omwancha J, Brown TR: Selective androgen receptor modulators: in pursuit of tissue-selective androgens. Curr Opin Investig Drugs. 2006 Oct;7(10):873-81. [PubMed:17086931]
  3. Petraki CD, Sfikas CP: Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. Histol Histopathol. 2007 Jan;22(1):107-18. [PubMed:17128417]
  4. Maudsley S, Davidson L, Pawson AJ, Freestone SH, Lopez de Maturana R, Thomson AA, Millar RP: Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2006;84(5):285-300. Epub 2007 Jan 4. [PubMed:17202804]
  5. Lapauw B, Goemaere S, Crabbe P, Kaufman JM, Ruige JB: Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? Eur J Endocrinol. 2007 Mar;156(3):395-401. [PubMed:17322500]
  6. Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, Marhefka CA, Veverka KA, Miller DD, Dalton JT: Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40. [PubMed:12604714]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
O-methyltransferase activity
Specific Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOP...
Gene Name
COMT
Uniprot ID
P21964
Uniprot Name
Catechol O-methyltransferase
Molecular Weight
30036.77 Da
References
  1. Ladosky W, Schneider HT: Changes in hypothalamic catechol-O-methyl-transferase during sexual differentiation of the brain. Braz J Med Biol Res. 1981 Dec;14(6):409-13. [PubMed:6153046]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
Gene Name
UGT1A1
Uniprot ID
P22309
Uniprot Name
UDP-glucuronosyltransferase 1-1
Molecular Weight
59590.91 Da
References
  1. Stern ST, Tallman MN, Miles KK, Ritter JK, Smith PC: Androgen regulation of renal uridine diphosphoglucuronosyltransferase 1A1 in rats. Drug Metab Dispos. 2008 Sep;36(9):1737-9. doi: 10.1124/dmd.108.020610. Epub 2008 May 30. [PubMed:18515331]
Kind
Protein group
Organism
Not Available
Pharmacological action
No
Actions
Substrate
General Function
Electron carrier activity
Specific Function
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and andro...

Components:
References
  1. Empowerpharmacy [Link]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Empowerpharmacy [Link]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Androgen binding
Specific Function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone...
Gene Name
SHBG
Uniprot ID
P04278
Uniprot Name
Sex hormone-binding globulin
Molecular Weight
43778.755 Da
References
  1. Empowerpharmacy [Link]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Empowerpharmacy [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Empowerpharmacy [Link]

Drug created on July 24, 2007 03:23 / Updated on August 15, 2018 09:51