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Displaying drugs 201 - 225 of 11565 in total

Methotrexate

Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Description: … Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis …
Matched Categories: … OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … METOTREXATO 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE …

Sultamicillin

Sultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).
Approved
Investigational
Matched Products: … TYCLAR® 250MG/5ML POLVO PARA RECONSTITUIR A SUSPENSIÓN ORAL. …

Carvedilol

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Lithium carbonate

Lithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Approved
Matched Description: … Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse …
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Ixazomib

Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to...
Approved
Investigational
Matched Description: … Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November ... Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …

Pemirolast

Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic...
Approved
Investigational
Matched Iupac: … 9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one …
Matched Description: … It is a mast cell stabilizer that acts as an antiallergic agent. ... Pemirolast potassium is a slightly yellow powder that is soluble in water. …

Praziquantel

Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat...
Approved
Investigational
Vet approved
Matched Iupac: … 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one …
Matched Description: … Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic ... Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis ... of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a …

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Description: … Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia ... Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Rivastigmine 1 A Pharma …

Codeine

The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Description: … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for ... Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease ... [A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic …
Matched Mixtures name: … Virtussin A/C ... Virtussin A/C ... Virtussin A/C …

Pitavastatin

Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Description: … (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid. ... Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the ... leading cause of death in high-income countries and a major cause of morbidity around the world. …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …

Palmitic Acid

A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
Approved
Matched Description: … A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. …

Clove oil

Clove oil is obtained by extraction from the dried flower buds of the clove plant. Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. It is also found in topical analgesics. Clove oil has shown to exert some antimicrobial activities. The antioxidant and antimicrobial...
Approved
Nutraceutical
Matched Description: … Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. ... The FDA categorizes clove oil as generally recognized as safe (GRAS) for use in dental cement or as a …

Synthetic camphor

Approved
Experimental
Matched Mixtures name: … Cho-A Point Plaster ... Cho-A Point Plaster ... Kank-A with Blistex Medicated Lip …

Factor IX Complex (Human)

Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of...
Approved
Investigational
Matched Description: … Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting …

Amphetamine

Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 and first...
Approved
Illicit
Investigational
Matched Description: … Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs ... It was previously used for a large variety of conditions and this changed until this point where its ... This use derived into a large overproduction of amphetamine and all the surplus after the war finalized …
Matched Mixtures name: … Mixed Salts of a Single-Entity Amphetamine Product ... Mixed Salts of a Single-Entity Amphetamine Product ... Mixed Salts of a Single-Entity Amphetamine Product …

Eslicarbazepine acetate

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body....
Approved
Matched Description: … Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active …

Propylthiouracil

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Approved
Investigational
Matched Description: … A thiourea antithyroid agent. …

Nitroglycerin

Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief...
Approved
Investigational
Matched Description: … Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent ... [A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and ... [A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Acenocoumarol

Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients...
Approved
Investigational
Matched Description: … Acenocoumarol is a coumarin derivative used as an anticoagulant. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Tipiracil

Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been...
Approved
Investigational
Matched Description: … Tipiracil is a thymidine phosphorylase inhibitor. ... It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. …
Matched Categories: … MATE 1 Substrates with a Narrow Therapeutic Index ... OCT2 Substrates with a Narrow Therapeutic Index …

Acyclovir

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA...
Approved
Matched Description: … Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster …
Matched Products: … ACICLOVIR250 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …

Diphenhydramine

Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269,...
Approved
Investigational
Matched Description: … Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation ... As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties. ... Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect …
Matched Mixtures name: … End-A-flu Multi-symptom Severe Cold and Cough Nighttime Formula …
Matched Products: … A Health Itch Relief Gel …

Carindacillin

Carindacillin or Carbenicillin isdanyl was an oral penicillin prodrug of carbenicillin marketed by Pfizer as Geocillin. It is no longer marketed in the United States.
Approved
Investigational

Bethanechol

Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For example, bethanechol is readily used to treat postoperative or...
Approved
Matched Description: … Bethanechol is a synthetic ester that was initially synthesized in 1935. ... [A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function …

Tegafur

Tegafur (INN, BAN, USAN) is a prodrug of DB00544 (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers. It is a pyrimidine analogue used in combination therapies as an active chemotherapeutic agent in conjunction with DB09257 and DB03209, or along with...
Approved
Investigational
Matched Description: … Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment ... its degradation, or serves to limit the toxicity of 5-FU by ensuring high concentrations of 5-FU at a ... It is a pyrimidine analogue used in combination therapies as an active chemotherapeutic agent in conjunction …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Displaying drugs 201 - 225 of 11565 in total