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Displaying drugs 151 - 175 of 1931 in total

Olaratumab

Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Studies show that the...
Approved
Investigational
Matched Description: … and blocks ligand binding. ... Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively ... binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Epoprostenol

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Approved
Matched Description: … A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. ... It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. …
Matched Categories: … Blood and Blood Forming Organs …

Tucatinib

Tucatinib is a kinase inhibitor drug used with trastuzumab and capecitabine in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer who...
Approved
Investigational
Matched Description: … It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. ... Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … Piracetam has neuroprotective and anticonvulsant properties and is reported to improve neural plasticity ... It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative ... Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Arsenic trioxide

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Selenium

Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species [FDA Label]
Approved
Investigational
Vet approved
Matched Description: … Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase ... , an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species …
Matched Mixtures name: … Multiple Vitamins and Minerals ... Vitamin E With Selenium and Zinc ... Henkel's Vitamin E and Selenium Cap …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism …

Tremelimumab

Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours...
Approved
Investigational
Matched Description: … Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against ... [A253717] By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours and reduces ... [A253717, A253722] After receiving an EMA Committee for Medicinal Products for Human Use (CHMP) recommendation …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Acetyl sulfisoxazole

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes...
Approved
Vet approved
Matched Description: … and pyrimidines, resulting in cell growth arrest and cell death [L2788]. ... Sulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog ... This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines …
Matched Mixtures name: … Erythromycin Ethylsuccinate and Sulfisoxazole Acetyl ... Erythromycin Ethylsuccinate and Sulfisoxazole Acetyl ... Erythromycin Ethylsuccinate and Sulfisoxazole Acetyl …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Venetoclax

Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Vorinostat

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Mefloquine

Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and...
Approved
Investigational
Matched Description: … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around ... Eastern Africa, nonimmune civilian and military travelers, pregnant women, and immigrants traveling ... It was approved by the FDA in 1989, and was first marketed by Hoffman Laroche. …
Matched Categories: … artesunate and mefloquine ... Antiparasitic Products, Insecticides and Repellents …

Albiglutide

Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on April 15, 2014 by the...
Approved
Matched Description: … It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). ... It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. …
Matched Categories: … Alimentary Tract and Metabolism ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Isavuconazonium

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Description: … [A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and ... Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July ... 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed …
Matched Categories: … Isavuconazole and Prodrugs …

Elvitegravir

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Description: … Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI ... Elvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. ... thereby blocks the formation of the HIV-1 provirus and resulting propagation of the viral infection. …
Matched Categories: … Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor ... emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat ... emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat …

Rituximab

Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … sequences and human constant region sequences [A40017], [FDA label]. ... Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the ... CD20 antigen found on the surface of normal and malignant B lymphocytes. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Ancestim

Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine . Ancestim was...
Approved
Investigational
Withdrawn
Matched Description: … Ancestim was developed by Amgen and sold to Biovitrium in December 2008. ... Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. ... produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Insulin degludec

Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human ... tissues such as the liver, fat cells, and skeletal muscle. ... inhibits lipolysis and proteolysis among many other functions. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin degludec and liraglutide ... insulin degludec and insulin aspart ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Amlodipine

Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched Description: … Amlodipine is commonly used in the treatment of high blood pressure and angina. ... Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), ... dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and …
Matched Mixtures name: … AMLODIPINE and VALSARTAN ... Amlodipine and Valsartan ... Amlodipine and Valsartan …
Matched Categories: … losartan and amlodipine ... ramipril and amlodipine ... nebivolol and amlodipine ... aliskiren and amlodipine ... valsartan and amlodipine …

Olodaterol

Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and...
Approved
Matched Description: … LABAs including improved convenience and compliance and improved airflow over a 24-hour period. ... novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and ... signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and …
Matched Categories: … olodaterol and tiotropium bromide …

Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated)

Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human respiratory tract.
Approved
Matched Description: … cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human …

Insulin glargine

Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human ... Insulin glargine differs from endogenous human insulin by the replacement of an asparagine residue at ... and proteolysis. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin glargine and lixisenatide ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Sodium fluoride

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as Fluoride ion F-18. Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated...
Approved
Matched Description: … chemical compound that is a source of the fluoride ion in many applications, including dental care and ... control dental caries is safe when used correctly and is highly effective in reducing the prevalence ... Dental Association (ADA), thorough evidence reviews have indicated that the use of fluoride to prevent and …
Matched Mixtures name: … Nicorette and Aquafresh Fruit Chill and Extreme Clean Whitening ... Twice Science and Wellness Invigorating Wintergreen and Peppermint ... Up and Up Sensitive Toothpaste …
Matched Categories: … Mouthwashes and Gargles ... Alimentary Tract and Metabolism …
Matched Products: … Maesa - Hey Human ... Truly Radiant Whitening and Strengthening Rinse CLEAN AND FRESH ... Fresh Brush and Cover …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … and minimal toxicity. ... [A7514] The effect of this drug has no homology in human host cells, which gives it excellent tolerability ... [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. …
Matched Categories: … Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor ... lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …

Ramipril

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Description: … It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ... Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to …
Matched Categories: … ACE Inhibitors and Diuretics ... ramipril and diuretics ... ramipril and felodipine ... ramipril and amlodipine ... ramipril and bisoprolol …

Pemirolast

Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic...
Approved
Investigational
Matched Description: … pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and …
Displaying drugs 151 - 175 of 1931 in total