Isavuconazonium

Identification

Name

Isavuconazonium

Accession Number

DB06636

Type

Small Molecule

Groups

Approved, Investigational

Description

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and parenteral formulations. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. This formulation also avoids the use of a cyclodextrin vehicle for solubilization required for intravenous administration of other antifungals such as voriconazole and posaconazole, eliminating concerns of nephrotoxicity associated with cyclodextrin. Isovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market.

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for DB06636 (Isavuconazonium)

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Synonyms

Not Available

External IDs

BAL-8557 / BAL8557

Product Ingredients

Ingredient	UNII	CAS	InChI Key
Isavuconazonium sulfate	31Q44514JV	946075-13-4	LWXUIUUOMSMZKJ-KLFWAVJMSA-M

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Cresemba	Capsule	186 mg/1	Oral	Astellas Pharma Inc	2015-03-06	2016-12-31
Cresemba	Capsule	186 mg/1	Oral	Astellas Pharma Inc	2015-11-04	Not applicable
Cresemba	Injection, powder, lyophilized, for solution	74.4 mg/mL	Intravenous	Astellas Pharma Inc	2015-03-06	Not applicable

Categories

• Azole Antifungals
• Combined Inhibitors of CYP3A4 and P-glycoprotein
• Cytochrome P-450 CYP3A Inducers
• Cytochrome P-450 CYP3A Inhibitors
• Cytochrome P-450 CYP3A4 Inducers (weak)
• Cytochrome P-450 CYP3A4 Inhibitors
• Cytochrome P-450 CYP3A4 Inhibitors (moderate)
• Cytochrome P-450 CYP3A4 Substrates
• Cytochrome P-450 Enzyme Inducers
• Cytochrome P-450 Enzyme Inhibitors
• P-glycoprotein/ABCB1 Inhibitors

UNII

VH2L779W8Q

CAS number

742049-41-8

Weight

Average: 717.77
Monoisotopic: 717.241370179

Chemical Formula

C₃₅H₃₅F₂N₈O₅S

InChI Key

RSWOJTICKMKTER-QXLBVTBOSA-N

InChI

InChI=1S/C35H35F2N8O5S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3/q+1/t22-,23?,35+/m0/s1

IUPAC Name

1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium

SMILES

[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[[email protected]](O)(C2=C(F)C=CC(F)=C2)[[email protected]@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1

Pharmacology

Indication

Indicated in the treatment of invasive aspergillosis and invasive mucormycosis.

Structured Indications

• Disseminated mucormycosis
• Invasive Aspergillosis

Pharmacodynamics

Not Available

Mechanism of action

Antifungals in the triazole class, such as isavuconazonium, target and inhibit the sterol 14-α-demethylase (Erg11p) which is a key player in the demethylation step of the ergosterol biosynthetic pathway. This inhibition results in a halt in production of ergosterol, a molecule typically found in the membranes of fungi such as Aspergillus, Candida, and Mucorales that plays a role in regulation of membrane integrity, fluidity and permeability. The inhibition of Erg11p also causes the buildup of ergosterol precursors, which are toxic and cause cell death.

Absorption

When administered intravenously as isavuconazonium, >99% of the prodrug is quickly converted to active isavuconazole (catalyzed by plasma esterases). Oral administration of isavuconazonium shows 98% oral bioavailability, however administration with food results in a 20% decrease in AUC (area under concentration-time curve) as well as decreasing maximum serum concentration (Cmax) by 50% and increasing time to Cmax by 1.5 hours.

Volume of distribution

450 L

Protein binding

>99%

Metabolism

Metabolism is primarily hepatic, with CYP3A4 and CYP3A5 involved in phase I metabolism, followed by modification by uridine diphosphate glucuronosyltransferase (UGT).

Route of elimination

45% excreted in feces and bile, and 45% excreted in urine as inactive metabolites. Less than 1% of active isavuconazole is excreted unchanged in urine.

Half life

80 to 130 hours.

Clearance

Not Available

Toxicity

Isavuconazole, the active moiety of isavuconazonium, is classified as Pregnancy Class C and should be avoided in pregnant women. It was also found to be excreted in breast milk in animal studies in rats, therefore it should be avoided in breastfeeding women.

Affected organisms

• Candida albicans and other yeasts
• Aspergillis, Candida and other fungi

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
Abemaciclib	The metabolism of Abemaciclib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Abiraterone	The metabolism of Abiraterone can be decreased when combined with Isavuconazonium.	Approved
Acenocoumarol	The metabolism of Acenocoumarol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Acetaminophen	The metabolism of Acetaminophen can be decreased when combined with Isavuconazonium.	Approved
Adinazolam	The metabolism of Adinazolam can be decreased when combined with Isavuconazonium.	Approved
Afatinib	The serum concentration of Afatinib can be increased when it is combined with Isavuconazonium.	Approved
Albendazole	The metabolism of Albendazole can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Alclometasone	The metabolism of Alclometasone can be decreased when combined with Isavuconazonium.	Approved
Alfentanil	The metabolism of Alfentanil can be decreased when combined with Isavuconazonium.	Approved, Illicit
Alfuzosin	The metabolism of Alfuzosin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Aliskiren	The metabolism of Aliskiren can be decreased when combined with Isavuconazonium.	Approved, Investigational
Allylestrenol	The metabolism of Allylestrenol can be decreased when combined with Isavuconazonium.	Approved
Almotriptan	The metabolism of Almotriptan can be decreased when combined with Isavuconazonium.	Approved, Investigational
Alogliptin	The metabolism of Alogliptin can be decreased when combined with Isavuconazonium.	Approved
Alosetron	The metabolism of Alosetron can be decreased when combined with Isavuconazonium.	Approved, Withdrawn
alpha-Tocopherol acetate	The metabolism of alpha-Tocopherol acetate can be decreased when combined with Isavuconazonium.	Approved
Alprazolam	The metabolism of Alprazolam can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational
Ambrisentan	The metabolism of Ambrisentan can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ambroxol	The metabolism of Ambroxol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Aminophenazone	The metabolism of Aminophenazone can be decreased when combined with Isavuconazonium.	Approved, Withdrawn
Aminophylline	The metabolism of Aminophylline can be decreased when combined with Isavuconazonium.	Approved
Amiodarone	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Amiodarone.	Approved, Investigational
Amitriptyline	The metabolism of Amitriptyline can be decreased when combined with Isavuconazonium.	Approved
Amlodipine	The metabolism of Amlodipine can be decreased when combined with Isavuconazonium.	Approved
Amprenavir	The metabolism of Amprenavir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Antipyrine	The metabolism of Antipyrine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Apalutamide	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Apalutamide resulting in a loss in efficacy.	Approved, Investigational
Apixaban	The serum concentration of Apixaban can be increased when it is combined with Isavuconazonium.	Approved
Apremilast	The metabolism of Apremilast can be decreased when combined with Isavuconazonium.	Approved, Investigational
Aprepitant	The serum concentration of Isavuconazonium can be increased when it is combined with Aprepitant.	Approved, Investigational
Argatroban	The metabolism of Argatroban can be decreased when combined with Isavuconazonium.	Approved, Investigational
Aripiprazole	The serum concentration of Aripiprazole can be decreased when it is combined with Isavuconazonium.	Approved, Investigational
Artemether	The metabolism of Artemether can be decreased when combined with Isavuconazonium.	Approved
Asenapine	The metabolism of Asenapine can be decreased when combined with Isavuconazonium.	Approved
Astemizole	The metabolism of Astemizole can be decreased when combined with Isavuconazonium.	Approved, Withdrawn
Asunaprevir	The serum concentration of Asunaprevir can be decreased when it is combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Atazanavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Atazanavir.	Approved, Investigational
Atomoxetine	The metabolism of Isavuconazonium can be decreased when combined with Atomoxetine.	Approved
Atorvastatin	The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Atorvastatin.	Approved
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Isavuconazonium.	Approved
Axitinib	The metabolism of Axitinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Azelastine	The metabolism of Azelastine can be decreased when combined with Isavuconazonium.	Approved
Azithromycin	The metabolism of Azithromycin can be decreased when combined with Isavuconazonium.	Approved
Banoxantrone	The metabolism of Banoxantrone can be decreased when combined with Isavuconazonium.	Investigational
Baricitinib	The metabolism of Baricitinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Bedaquiline	The metabolism of Bedaquiline can be decreased when combined with Isavuconazonium.	Approved
Benidipine	The metabolism of Benidipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Benzphetamine	The metabolism of Benzphetamine can be decreased when combined with Isavuconazonium.	Approved, Illicit
Benzyl alcohol	The metabolism of Benzyl alcohol can be decreased when combined with Isavuconazonium.	Approved
Bexarotene	The metabolism of Bexarotene can be decreased when combined with Isavuconazonium.	Approved, Investigational
Bezafibrate	The metabolism of Bezafibrate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Bicalutamide	The metabolism of Bicalutamide can be decreased when combined with Isavuconazonium.	Approved
Bictegravir	The metabolism of Bictegravir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Bisoprolol	The metabolism of Bisoprolol can be decreased when combined with Isavuconazonium.	Approved
Blonanserin	The metabolism of Blonanserin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Boceprevir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir.	Approved, Withdrawn
Bortezomib	The metabolism of Isavuconazonium can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The serum concentration of Bosentan can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Isavuconazonium.	Approved
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Brexpiprazole	The serum concentration of Brexpiprazole can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Brigatinib	The metabolism of Brigatinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Brinzolamide	The metabolism of Brinzolamide can be decreased when combined with Isavuconazonium.	Approved
Brivaracetam	The metabolism of Brivaracetam can be decreased when combined with Isavuconazonium.	Approved, Investigational
Bromazepam	The metabolism of Bromazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational
Bromocriptine	The risk or severity of adverse effects can be increased when Bromocriptine is combined with Isavuconazonium.	Approved, Investigational
Brompheniramine	The metabolism of Brompheniramine can be decreased when combined with Isavuconazonium.	Approved
Budesonide	The serum concentration of Budesonide can be increased when it is combined with Isavuconazonium.	Approved
Bupivacaine	The metabolism of Bupivacaine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Buprenorphine	The metabolism of Buprenorphine can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational, Vet Approved
Bupropion	The serum concentration of Bupropion can be decreased when it is combined with Isavuconazonium.	Approved
Buspirone	The metabolism of Buspirone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Busulfan	The metabolism of Busulfan can be decreased when combined with Isavuconazonium.	Approved, Investigational
Cabazitaxel	The metabolism of Cabazitaxel can be decreased when combined with Isavuconazonium.	Approved
Cabergoline	The risk or severity of adverse effects can be increased when Cabergoline is combined with Isavuconazonium.	Approved
Cabozantinib	The metabolism of Cabozantinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Caffeine	The metabolism of Caffeine can be decreased when combined with Isavuconazonium.	Approved
Calcitriol	The metabolism of Calcitriol can be decreased when combined with Isavuconazonium.	Approved, Nutraceutical
Canagliflozin	The metabolism of Canagliflozin can be decreased when combined with Isavuconazonium.	Approved
Cannabidiol	The metabolism of Cannabidiol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Carbamazepine	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Carbamazepine resulting in a loss in efficacy.	Approved, Investigational
Carbinoxamine	The metabolism of Carbinoxamine can be decreased when combined with Isavuconazonium.	Approved
Cariprazine	The metabolism of Cariprazine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Carvedilol	The metabolism of Carvedilol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Celecoxib	The metabolism of Celecoxib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Celiprolol	The metabolism of Celiprolol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Cephalexin	The metabolism of Cephalexin can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Ceritinib	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ceritinib.	Approved
Cerivastatin	The serum concentration of Cerivastatin can be increased when it is combined with Isavuconazonium.	Approved, Withdrawn
Cevimeline	The metabolism of Cevimeline can be decreased when combined with Isavuconazonium.	Approved
Chenodeoxycholic acid	The metabolism of Chenodeoxycholic acid can be decreased when combined with Isavuconazonium.	Approved
Chlordiazepoxide	The metabolism of Chlordiazepoxide can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational
Chloroquine	The metabolism of Chloroquine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Chlorphenamine	The metabolism of Chlorphenamine can be decreased when combined with Isavuconazonium.	Approved
Chlorpromazine	The metabolism of Chlorpromazine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Chlorzoxazone	The metabolism of Chlorzoxazone can be decreased when combined with Isavuconazonium.	Approved
Cholecalciferol	The metabolism of Cholecalciferol can be decreased when combined with Isavuconazonium.	Approved, Nutraceutical
Ciclesonide	The metabolism of Ciclesonide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Cilostazol	The serum concentration of Cilostazol can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Cinacalcet	The metabolism of Cinacalcet can be decreased when combined with Isavuconazonium.	Approved
Cisapride	The metabolism of Cisapride can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Citalopram	The metabolism of Citalopram can be decreased when combined with Isavuconazonium.	Approved
Clarithromycin	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Clarithromycin.	Approved
Clemastine	The metabolism of Isavuconazonium can be decreased when combined with Clemastine.	Approved, Investigational
Clindamycin	The metabolism of Clindamycin can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Clobazam	The metabolism of Clobazam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Clofazimine	The metabolism of Clofazimine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Clofibrate	The metabolism of Clofibrate can be decreased when combined with Isavuconazonium.	Approved, Investigational
clomethiazole	The metabolism of clomethiazole can be decreased when combined with Isavuconazonium.	Investigational
Clomipramine	The metabolism of Clomipramine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Clonazepam	The metabolism of Clonazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Clonidine	The metabolism of Clonidine can be decreased when combined with Isavuconazonium.	Approved
Clopidogrel	The metabolism of Clopidogrel can be decreased when combined with Isavuconazonium.	Approved
Clorazepate	The metabolism of Clorazepate can be decreased when combined with Isavuconazonium.	Approved, Illicit
Clotiazepam	The metabolism of Clotiazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Clotrimazole	The metabolism of Isavuconazonium can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The metabolism of Clozapine can be decreased when combined with Isavuconazonium.	Approved
Cobicistat	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Cobicistat.	Approved
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Cocaine	The metabolism of Cocaine can be decreased when combined with Isavuconazonium.	Approved, Illicit
Codeine	The metabolism of Codeine can be decreased when combined with Isavuconazonium.	Approved, Illicit
Colchicine	The serum concentration of Colchicine can be increased when it is combined with Isavuconazonium.	Approved
Conivaptan	The serum concentration of Conivaptan can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Conjugated estrogens	The metabolism of Conjugated estrogens can be decreased when combined with Isavuconazonium.	Approved
Copanlisib	The metabolism of Copanlisib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Cortisone acetate	The metabolism of Cortisone acetate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Crizotinib	The metabolism of Isavuconazonium can be decreased when combined with Crizotinib.	Approved
Cyclobenzaprine	The metabolism of Cyclobenzaprine can be decreased when combined with Isavuconazonium.	Approved
Cyclophosphamide	The metabolism of Cyclophosphamide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Cyclosporine	The metabolism of Isavuconazonium can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Cytarabine	The metabolism of Cytarabine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dabigatran etexilate	The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Isavuconazonium.	Approved
Dabrafenib	The serum concentration of Isavuconazonium can be decreased when it is combined with Dabrafenib.	Approved, Investigational
Daclatasvir	The metabolism of Daclatasvir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dantrolene	The metabolism of Dantrolene can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dapagliflozin	The metabolism of Dapagliflozin can be decreased when combined with Isavuconazonium.	Approved
Dapoxetine	The serum concentration of Dapoxetine can be increased when it is combined with Isavuconazonium.	Investigational
Dapsone	The metabolism of Dapsone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Darifenacin	The metabolism of Darifenacin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Darunavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir.	Approved
Dasabuvir	The metabolism of Dasabuvir can be decreased when combined with Isavuconazonium.	Approved
Dasatinib	The serum concentration of Isavuconazonium can be increased when it is combined with Dasatinib.	Approved, Investigational
Daunorubicin	The metabolism of Daunorubicin can be decreased when combined with Isavuconazonium.	Approved
Deferasirox	The serum concentration of Isavuconazonium can be decreased when it is combined with Deferasirox.	Approved, Investigational
Deflazacort	The metabolism of Deflazacort can be decreased when combined with Isavuconazonium.	Approved, Investigational
Delavirdine	The metabolism of Isavuconazonium can be decreased when combined with Delavirdine.	Approved
Desvenlafaxine	The metabolism of Desvenlafaxine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Deutetrabenazine	The metabolism of Deutetrabenazine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dexamethasone	The metabolism of Dexamethasone can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Dexchlorpheniramine maleate	The metabolism of Dexchlorpheniramine maleate can be decreased when combined with Isavuconazonium.	Approved
Dexlansoprazole	The metabolism of Dexlansoprazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dextromethorphan	The metabolism of Dextromethorphan can be decreased when combined with Isavuconazonium.	Approved
Dextropropoxyphene	The metabolism of Dextropropoxyphene can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational, Withdrawn
Diazepam	The metabolism of Diazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational, Vet Approved
Diclofenac	The metabolism of Diclofenac can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Dienogest	The metabolism of Dienogest can be decreased when combined with Isavuconazonium.	Approved
Digitoxin	The metabolism of Digitoxin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Isavuconazonium.	Approved
Dihydrocodeine	The metabolism of Dihydrocodeine can be decreased when combined with Isavuconazonium.	Approved, Illicit
Dihydroergocornine	The risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Isavuconazonium.	Approved
Dihydroergocristine	The risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Isavuconazonium.	Approved, Experimental
Dihydroergocryptine	The risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Isavuconazonium.	Experimental
Dihydroergotamine	The risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Isavuconazonium.	Approved, Investigational
Diltiazem	The metabolism of Isavuconazonium can be decreased when combined with Diltiazem.	Approved, Investigational
Disopyramide	The metabolism of Disopyramide can be decreased when combined with Isavuconazonium.	Approved
Disulfiram	The metabolism of Disulfiram can be decreased when combined with Isavuconazonium.	Approved
Docetaxel	The metabolism of Docetaxel can be decreased when combined with Isavuconazonium.	Approved, Investigational
Dofetilide	The serum concentration of Dofetilide can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Dolasetron	The metabolism of Dolasetron can be decreased when combined with Isavuconazonium.	Approved, Investigational
Domperidone	The serum concentration of Domperidone can be increased when it is combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Donepezil	The metabolism of Donepezil can be decreased when combined with Isavuconazonium.	Approved
Dorzolamide	The metabolism of Dorzolamide can be decreased when combined with Isavuconazonium.	Approved
Doxepin	The metabolism of Doxepin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Doxorubicin	The metabolism of Doxorubicin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Doxycycline	The metabolism of Isavuconazonium can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
Dronabinol	The serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium.	Approved, Illicit
Dronedarone	The metabolism of Isavuconazonium can be decreased when combined with Dronedarone.	Approved
Dutasteride	The metabolism of Dutasteride can be decreased when combined with Isavuconazonium.	Approved, Investigational
Edoxaban	The serum concentration of Edoxaban can be increased when it is combined with Isavuconazonium.	Approved
Efavirenz	The metabolism of Efavirenz can be decreased when combined with Isavuconazonium.	Approved, Investigational
Elbasvir	The metabolism of Elbasvir can be decreased when combined with Isavuconazonium.	Approved
Eletriptan	The serum concentration of Eletriptan can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Eliglustat	The serum concentration of Eliglustat can be increased when it is combined with Isavuconazonium.	Approved
Elvitegravir	The metabolism of Elvitegravir can be decreased when combined with Isavuconazonium.	Approved
Enalapril	The metabolism of Enalapril can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Enasidenib	The metabolism of Enasidenib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Enzalutamide	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Enzalutamide resulting in a loss in efficacy.	Approved
Epinastine	The metabolism of Epinastine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Eplerenone	The serum concentration of Eplerenone can be increased when it is combined with Isavuconazonium.	Approved
Ergocalciferol	The metabolism of Ergocalciferol can be decreased when combined with Isavuconazonium.	Approved, Nutraceutical
Ergoloid mesylate	The metabolism of Ergoloid mesylate can be decreased when combined with Isavuconazonium.	Approved
Ergonovine	The risk or severity of adverse effects can be increased when Ergonovine is combined with Isavuconazonium.	Approved
Ergotamine	The risk or severity of adverse effects can be increased when Ergotamine is combined with Isavuconazonium.	Approved
Erlotinib	The metabolism of Erlotinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Erythromycin	The metabolism of Isavuconazonium can be decreased when combined with Erythromycin.	Approved, Investigational, Vet Approved
Escitalopram	The metabolism of Escitalopram can be decreased when combined with Isavuconazonium.	Approved, Investigational
Esomeprazole	The metabolism of Esomeprazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Estazolam	The metabolism of Estazolam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Estradiol	The metabolism of Estradiol can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estradiol acetate	The metabolism of Estradiol acetate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estradiol benzoate	The metabolism of Estradiol benzoate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estradiol cypionate	The metabolism of Estradiol cypionate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estradiol dienanthate	The metabolism of Estradiol dienanthate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estradiol valerate	The metabolism of Estradiol valerate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Estramustine	The metabolism of Estramustine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Estrogens, esterified	The metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium.	Approved
Estrone	The metabolism of Estrone can be decreased when combined with Isavuconazonium.	Approved
Estrone sulfate	The metabolism of Estrone sulfate can be decreased when combined with Isavuconazonium.	Approved
Eszopiclone	The metabolism of Eszopiclone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ethanol	The metabolism of Ethanol can be decreased when combined with Isavuconazonium.	Approved
Ethinyl Estradiol	The metabolism of Ethinyl Estradiol can be decreased when combined with Isavuconazonium.	Approved
Ethosuximide	The metabolism of Ethosuximide can be decreased when combined with Isavuconazonium.	Approved
Ethylmorphine	The metabolism of Ethylmorphine can be decreased when combined with Isavuconazonium.	Approved, Illicit
Etizolam	The metabolism of Etizolam can be decreased when combined with Isavuconazonium.	Approved
Etonogestrel	The metabolism of Etonogestrel can be decreased when combined with Isavuconazonium.	Approved, Investigational
Etoposide	The metabolism of Etoposide can be decreased when combined with Isavuconazonium.	Approved
Etoricoxib	The metabolism of Etoricoxib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Etravirine	The metabolism of Etravirine can be decreased when combined with Isavuconazonium.	Approved
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Isavuconazonium.	Approved
Exemestane	The metabolism of Exemestane can be decreased when combined with Isavuconazonium.	Approved, Investigational
Famciclovir	The metabolism of Famciclovir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Felbamate	The metabolism of Felbamate can be decreased when combined with Isavuconazonium.	Approved
Felodipine	The metabolism of Felodipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Fenofibrate	The metabolism of Fenofibrate can be decreased when combined with Isavuconazonium.	Approved
Fentanyl	The serum concentration of Fentanyl can be increased when it is combined with Isavuconazonium.	Approved, Illicit, Investigational, Vet Approved
Fesoterodine	The metabolism of Fesoterodine can be decreased when combined with Isavuconazonium.	Approved
Finasteride	The metabolism of Finasteride can be decreased when combined with Isavuconazonium.	Approved
Fingolimod	The metabolism of Fingolimod can be decreased when combined with Isavuconazonium.	Approved, Investigational
Flibanserin	The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Flibanserin.	Approved, Investigational
Fluconazole	The metabolism of Isavuconazonium can be decreased when combined with Fluconazole.	Approved, Investigational
Flunisolide	The metabolism of Flunisolide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Flunitrazepam	The metabolism of Flunitrazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Fluorometholone	The metabolism of Fluorometholone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Fluoxetine	The metabolism of Fluoxetine can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Flurazepam	The metabolism of Flurazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational
Flutamide	The metabolism of Flutamide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Fluticasone furoate	The metabolism of Fluticasone furoate can be decreased when combined with Isavuconazonium.	Approved
Fluticasone propionate	The metabolism of Fluticasone propionate can be decreased when combined with Isavuconazonium.	Approved
Fluvastatin	The serum concentration of Fluvastatin can be increased when it is combined with Isavuconazonium.	Approved
Fluvoxamine	The metabolism of Isavuconazonium can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The metabolism of Isavuconazonium can be decreased when combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Isavuconazonium can be increased when it is combined with Fosaprepitant.	Approved
Fosphenytoin	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Fosphenytoin resulting in a loss in efficacy.	Approved, Investigational
Fulvestrant	The metabolism of Fulvestrant can be decreased when combined with Isavuconazonium.	Approved, Investigational
Fusidic Acid	The serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Galantamine	The metabolism of Galantamine can be decreased when combined with Isavuconazonium.	Approved
Gefitinib	The metabolism of Gefitinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Gemfibrozil	The metabolism of Gemfibrozil can be decreased when combined with Isavuconazonium.	Approved
Glipizide	The metabolism of Glipizide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Glyburide	The metabolism of Glyburide can be decreased when combined with Isavuconazonium.	Approved
Granisetron	The metabolism of Granisetron can be decreased when combined with Isavuconazonium.	Approved, Investigational
Grazoprevir	The metabolism of Grazoprevir can be decreased when combined with Isavuconazonium.	Approved
Grepafloxacin	The metabolism of Grepafloxacin can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Guanfacine	The metabolism of Guanfacine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Halofantrine	The serum concentration of Halofantrine can be increased when it is combined with Isavuconazonium.	Approved
Haloperidol	The metabolism of Haloperidol can be decreased when combined with Isavuconazonium.	Approved
Halothane	The metabolism of Halothane can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Hexobarbital	The metabolism of Hexobarbital can be decreased when combined with Isavuconazonium.	Approved
Histamine	The metabolism of Histamine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Hydrocodone	The serum concentration of Hydrocodone can be increased when it is combined with Isavuconazonium.	Approved, Illicit
Hydrocortisone	The metabolism of Hydrocortisone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Hydromorphone	The metabolism of Hydromorphone can be decreased when combined with Isavuconazonium.	Approved, Illicit
Hydroxyprogesterone caproate	The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ibrutinib	The serum concentration of Ibrutinib can be increased when it is combined with Isavuconazonium.	Approved
Icotinib	The metabolism of Icotinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Idelalisib	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Idelalisib.	Approved
Ifosfamide	The serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Isavuconazonium resulting in a loss in efficacy.	Approved
Iloperidone	The metabolism of Iloperidone can be decreased when combined with Isavuconazonium.	Approved
Imatinib	The serum concentration of Imatinib can be increased when it is combined with Isavuconazonium.	Approved
Imidafenacin	The metabolism of Imidafenacin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Imipramine	The metabolism of Imipramine can be decreased when combined with Isavuconazonium.	Approved
Imiquimod	The metabolism of Imiquimod can be decreased when combined with Isavuconazonium.	Approved, Investigational
Indacaterol	The metabolism of Indacaterol can be decreased when combined with Isavuconazonium.	Approved
Indapamide	The metabolism of Indapamide can be decreased when combined with Isavuconazonium.	Approved
Indinavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Indinavir.	Approved
Ipratropium bromide	The metabolism of Ipratropium bromide can be decreased when combined with Isavuconazonium.	Approved
Irinotecan	The metabolism of Irinotecan can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isavuconazole	The serum concentration of Isavuconazonium can be increased when it is combined with Isavuconazole.	Approved, Investigational
Isosorbide Dinitrate	The metabolism of Isosorbide Dinitrate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isosorbide Mononitrate	The metabolism of Isosorbide Mononitrate can be decreased when combined with Isavuconazonium.	Approved
Isradipine	The metabolism of Isavuconazonium can be decreased when combined with Isradipine.	Approved, Investigational
Itraconazole	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Itraconazole.	Approved, Investigational
Ivabradine	The serum concentration of Ivabradine can be increased when it is combined with Isavuconazonium.	Approved
Ivacaftor	The serum concentration of Ivacaftor can be increased when it is combined with Isavuconazonium.	Approved
Ivermectin	The metabolism of Ivermectin can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Ixabepilone	The metabolism of Ixabepilone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ixazomib	The metabolism of Ixazomib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ketamine	The metabolism of Ketamine can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Ketazolam	The metabolism of Ketazolam can be decreased when combined with Isavuconazonium.	Approved
Ketobemidone	The metabolism of Ketobemidone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ketoconazole	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ketoconazole.	Approved, Investigational
Lacidipine	The metabolism of Lacidipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Lansoprazole	The metabolism of Lansoprazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Lapatinib	The metabolism of Lapatinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Laquinimod	The metabolism of Laquinimod can be decreased when combined with Isavuconazonium.	Investigational
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with Isavuconazonium.	Approved
Lenvatinib	The metabolism of Lenvatinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Lercanidipine	The metabolism of Lercanidipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Letrozole	The metabolism of Letrozole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Levobupivacaine	The metabolism of Levobupivacaine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Levocetirizine	The metabolism of Levocetirizine can be decreased when combined with Isavuconazonium.	Approved
Levomethadyl Acetate	The metabolism of Levomethadyl Acetate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Levomilnacipran	The metabolism of Levomilnacipran can be decreased when combined with Isavuconazonium.	Approved, Investigational
Levonorgestrel	The metabolism of Levonorgestrel can be decreased when combined with Isavuconazonium.	Approved, Investigational
Levothyroxine	The metabolism of Levothyroxine can be decreased when combined with Isavuconazonium.	Approved
Lidocaine	The metabolism of Lidocaine can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Lisuride	The risk or severity of adverse effects can be increased when Lisuride is combined with Isavuconazonium.	Approved, Investigational
Lomitapide	The serum concentration of Lomitapide can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Loperamide	The metabolism of Loperamide can be decreased when combined with Isavuconazonium.	Approved
Lopinavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Lopinavir.	Approved
Loratadine	The metabolism of Loratadine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Lorcaserin	The metabolism of Lorcaserin can be decreased when combined with Isavuconazonium.	Approved
Lorpiprazole	The serum concentration of Isavuconazonium can be increased when it is combined with Lorpiprazole.	Approved
Losartan	The metabolism of Losartan can be decreased when combined with Isavuconazonium.	Approved
Lovastatin	The serum concentration of Lovastatin can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Luliconazole	The serum concentration of Isavuconazonium can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Lumacaftor resulting in a loss in efficacy.	Approved
Lumefantrine	The metabolism of Lumefantrine can be decreased when combined with Isavuconazonium.	Approved
Lurasidone	The serum concentration of Lurasidone can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Lysergic Acid Diethylamide	The risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Isavuconazonium.	Illicit, Investigational, Withdrawn
Macimorelin	The metabolism of Macimorelin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Macitentan	The metabolism of Macitentan can be decreased when combined with Isavuconazonium.	Approved
Maraviroc	The metabolism of Maraviroc can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mebendazole	The metabolism of Mebendazole can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Medroxyprogesterone acetate	The metabolism of Medroxyprogesterone acetate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mefloquine	The metabolism of Mefloquine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Meloxicam	The metabolism of Meloxicam can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Metergoline	The risk or severity of adverse effects can be increased when Metergoline is combined with Isavuconazonium.	Experimental
Methadone	The metabolism of Methadone can be decreased when combined with Isavuconazonium.	Approved
Methaqualone	The metabolism of Methaqualone can be decreased when combined with Isavuconazonium.	Illicit, Withdrawn
Methoxsalen	The metabolism of Methoxsalen can be decreased when combined with Isavuconazonium.	Approved
Methoxyflurane	The metabolism of Methoxyflurane can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Methylergometrine	The risk or severity of adverse effects can be increased when Methylergometrine is combined with Isavuconazonium.	Approved
Methylprednisolone	The metabolism of Methylprednisolone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Methyltestosterone	The metabolism of Methyltestosterone can be decreased when combined with Isavuconazonium.	Approved
Methysergide	The risk or severity of adverse effects can be increased when Methysergide is combined with Isavuconazonium.	Approved
Metronidazole	The metabolism of Metronidazole can be decreased when combined with Isavuconazonium.	Approved
Mevastatin	The serum concentration of Mevastatin can be increased when it is combined with Isavuconazonium.	Experimental
Mexiletine	The metabolism of Mexiletine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mianserin	The metabolism of Mianserin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mibefradil	The metabolism of Mibefradil can be decreased when combined with Isavuconazonium.	Investigational, Withdrawn
Miconazole	The metabolism of Miconazole can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Midazolam	The metabolism of Midazolam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Midostaurin	The metabolism of Midostaurin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mifepristone	The serum concentration of Isavuconazonium can be increased when it is combined with Mifepristone.	Approved, Investigational
Mirabegron	The metabolism of Mirabegron can be decreased when combined with Isavuconazonium.	Approved
Mirtazapine	The metabolism of Mirtazapine can be decreased when combined with Isavuconazonium.	Approved
Mitotane	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Mitotane resulting in a loss in efficacy.	Approved
Modafinil	The metabolism of Modafinil can be decreased when combined with Isavuconazonium.	Approved, Investigational
Montelukast	The metabolism of Montelukast can be decreased when combined with Isavuconazonium.	Approved
Morphine	The metabolism of Morphine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mycophenolate mofetil	The metabolism of Mycophenolate mofetil can be decreased when combined with Isavuconazonium.	Approved, Investigational
Mycophenolic acid	The serum concentration of Mycophenolic acid can be increased when it is combined with Isavuconazonium.	Approved
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Isavuconazonium.	Approved
Naloxone	The metabolism of Naloxone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Nateglinide	The metabolism of Nateglinide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Nefazodone	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nefazodone.	Approved, Withdrawn
Nelfinavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nelfinavir.	Approved
Neratinib	The metabolism of Neratinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Netupitant	The serum concentration of Isavuconazonium can be increased when it is combined with Netupitant.	Approved, Investigational
Nevirapine	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Nevirapine resulting in a loss in efficacy.	Approved
Nicardipine	The metabolism of Nicardipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Nicergoline	The risk or severity of adverse effects can be increased when Nicergoline is combined with Isavuconazonium.	Approved, Investigational
Nicotine	The metabolism of Nicotine can be decreased when combined with Isavuconazonium.	Approved
Nifedipine	The metabolism of Nifedipine can be decreased when combined with Isavuconazonium.	Approved
Nilotinib	The metabolism of Isavuconazonium can be decreased when combined with Nilotinib.	Approved, Investigational
Nilvadipine	The metabolism of Nilvadipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Nimodipine	The serum concentration of Nimodipine can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Nintedanib	The serum concentration of Nintedanib can be increased when it is combined with Isavuconazonium.	Approved
Nisoldipine	The metabolism of Nisoldipine can be decreased when combined with Isavuconazonium.	Approved
Nitrazepam	The metabolism of Nitrazepam can be decreased when combined with Isavuconazonium.	Approved
Nitrendipine	The metabolism of Nitrendipine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Norethisterone	The metabolism of Norethisterone can be decreased when combined with Isavuconazonium.	Approved
Norgestrel	The metabolism of Norgestrel can be decreased when combined with Isavuconazonium.	Approved
Nortriptyline	The metabolism of Nortriptyline can be decreased when combined with Isavuconazonium.	Approved
Odanacatib	The metabolism of Odanacatib can be decreased when combined with Isavuconazonium.	Investigational
Olaparib	The serum concentration of Olaparib can be increased when it is combined with Isavuconazonium.	Approved
Olopatadine	The metabolism of Olopatadine can be decreased when combined with Isavuconazonium.	Approved
Omeprazole	The metabolism of Omeprazole can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Ondansetron	The metabolism of Ondansetron can be decreased when combined with Isavuconazonium.	Approved
Opium	The metabolism of Opium can be decreased when combined with Isavuconazonium.	Approved, Illicit
Orphenadrine	The metabolism of Orphenadrine can be decreased when combined with Isavuconazonium.	Approved
Osimertinib	The serum concentration of Isavuconazonium can be increased when it is combined with Osimertinib.	Approved
Ospemifene	The metabolism of Ospemifene can be decreased when combined with Isavuconazonium.	Approved, Investigational
Oxazepam	The metabolism of Oxazepam can be decreased when combined with Isavuconazonium.	Approved
Oxybutynin	The metabolism of Oxybutynin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Oxycodone	The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Oxycodone.	Approved, Illicit, Investigational
Oxymorphone	The metabolism of Oxymorphone can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Paclitaxel	The metabolism of Paclitaxel can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Palbociclib	The serum concentration of Isavuconazonium can be increased when it is combined with Palbociclib.	Approved, Investigational
Palonosetron	The metabolism of Palonosetron can be decreased when combined with Isavuconazonium.	Approved, Investigational
Panobinostat	The metabolism of Panobinostat can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pantoprazole	The metabolism of Pantoprazole can be decreased when combined with Isavuconazonium.	Approved
Paramethadione	The metabolism of Paramethadione can be decreased when combined with Isavuconazonium.	Approved
Paramethasone	The metabolism of Paramethasone can be decreased when combined with Isavuconazonium.	Approved
Parecoxib	The metabolism of Parecoxib can be decreased when combined with Isavuconazonium.	Approved
Paricalcitol	The metabolism of Paricalcitol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Paritaprevir	The metabolism of Paritaprevir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Isavuconazonium.	Approved
Pentamidine	The metabolism of Pentamidine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pentobarbital	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Pentobarbital resulting in a loss in efficacy.	Approved, Investigational, Vet Approved
Perampanel	The metabolism of Perampanel can be decreased when combined with Isavuconazonium.	Approved
Pergolide	The risk or severity of adverse effects can be increased when Pergolide is combined with Isavuconazonium.	Approved, Investigational, Vet Approved, Withdrawn
Perhexiline	The metabolism of Perhexiline can be decreased when combined with Isavuconazonium.	Approved, Investigational
Permethrin	The metabolism of Permethrin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Perospirone	The metabolism of Perospirone can be decreased when combined with Isavuconazonium.	Approved
Perphenazine	The metabolism of Perphenazine can be decreased when combined with Isavuconazonium.	Approved
Pethidine	The metabolism of Pethidine can be decreased when combined with Isavuconazonium.	Approved
Phenacetin	The metabolism of Phenacetin can be decreased when combined with Isavuconazonium.	Withdrawn
Phenobarbital	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenobarbital resulting in a loss in efficacy.	Approved, Investigational
Phenoxybenzamine	The metabolism of Phenoxybenzamine can be decreased when combined with Isavuconazonium.	Approved
Phenprocoumon	The metabolism of Phenprocoumon can be decreased when combined with Isavuconazonium.	Approved, Investigational
Phenytoin	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenytoin resulting in a loss in efficacy.	Approved, Vet Approved
Pilocarpine	The metabolism of Pilocarpine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pimecrolimus	The metabolism of Pimecrolimus can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pimozide	The serum concentration of Pimozide can be increased when it is combined with Isavuconazonium.	Approved
Pinacidil	The metabolism of Pinacidil can be decreased when combined with Isavuconazonium.	Approved
Pioglitazone	The metabolism of Pioglitazone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Piperaquine	The metabolism of Piperaquine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pipotiazine	The metabolism of Pipotiazine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Pitavastatin	The serum concentration of Pitavastatin can be increased when it is combined with Isavuconazonium.	Approved
Pitolisant	The serum concentration of Isavuconazonium can be decreased when it is combined with Pitolisant.	Approved, Investigational
Podofilox	The metabolism of Podofilox can be decreased when combined with Isavuconazonium.	Approved
Pomalidomide	The metabolism of Pomalidomide can be decreased when combined with Isavuconazonium.	Approved
Ponatinib	The metabolism of Ponatinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Posaconazole	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Posaconazole.	Approved, Investigational, Vet Approved
Prasterone	The metabolism of Prasterone can be decreased when combined with Isavuconazonium.	Approved, Investigational, Nutraceutical
Prasugrel	The metabolism of Prasugrel can be decreased when combined with Isavuconazonium.	Approved
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with Isavuconazonium.	Approved
Prazepam	The metabolism of Prazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Praziquantel	The metabolism of Praziquantel can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Prednisolone	The metabolism of Prednisolone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Prednisone	The metabolism of Prednisone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Primaquine	The metabolism of Primaquine can be decreased when combined with Isavuconazonium.	Approved
Primidone	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Primidone resulting in a loss in efficacy.	Approved, Vet Approved
Prochlorperazine	The metabolism of Prochlorperazine can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Progesterone	The metabolism of Progesterone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Proguanil	The metabolism of Proguanil can be decreased when combined with Isavuconazonium.	Approved
Promazine	The metabolism of Promazine can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Propafenone	The serum concentration of Propafenone can be increased when it is combined with Isavuconazonium.	Approved
Propofol	The metabolism of Propofol can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Propoxyphene napsylate	The metabolism of Propoxyphene napsylate can be decreased when combined with Isavuconazonium.	Approved
Propranolol	The metabolism of Propranolol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Prucalopride	The serum concentration of Prucalopride can be increased when it is combined with Isavuconazonium.	Approved
Pyrazinamide	The metabolism of Pyrazinamide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Quazepam	The metabolism of Quazepam can be decreased when combined with Isavuconazonium.	Approved, Illicit
Quetiapine	The metabolism of Quetiapine can be decreased when combined with Isavuconazonium.	Approved
Quinacrine	The metabolism of Quinacrine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Quinidine	The metabolism of Quinidine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Quinine	The metabolism of Quinine can be decreased when combined with Isavuconazonium.	Approved
Rabeprazole	The metabolism of Rabeprazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Raloxifene	The metabolism of Raloxifene can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ramelteon	The metabolism of Ramelteon can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ranolazine	The serum concentration of Ranolazine can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Reboxetine	The metabolism of Reboxetine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Regorafenib	The metabolism of Regorafenib can be decreased when combined with Isavuconazonium.	Approved
Repaglinide	The metabolism of Repaglinide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Retapamulin	The metabolism of Retapamulin can be decreased when combined with Isavuconazonium.	Approved
Rifabutin	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy.	Approved, Investigational
Rifampicin	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.	Approved
Rifapentine	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifapentine resulting in a loss in efficacy.	Approved, Investigational
Rifaximin	The serum concentration of Rifaximin can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Rilpivirine	The serum concentration of Rilpivirine can be decreased when it is combined with Isavuconazonium.	Approved
Rimonabant	The metabolism of Rimonabant can be decreased when combined with Isavuconazonium.	Approved, Investigational
Riociguat	The metabolism of Riociguat can be decreased when combined with Isavuconazonium.	Approved
Risperidone	The metabolism of Risperidone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ritonavir	The metabolism of Ritonavir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Rivaroxaban	The metabolism of Rivaroxaban can be decreased when combined with Isavuconazonium.	Approved
Rofecoxib	The metabolism of Rofecoxib can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Rolapitant	The metabolism of Rolapitant can be decreased when combined with Isavuconazonium.	Approved, Investigational
Romidepsin	The metabolism of Romidepsin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ropinirole	The metabolism of Ropinirole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ropivacaine	The metabolism of Ropivacaine can be decreased when combined with Isavuconazonium.	Approved
Rosuvastatin	The serum concentration of Rosuvastatin can be increased when it is combined with Isavuconazonium.	Approved
Rotigotine	The metabolism of Rotigotine can be decreased when combined with Isavuconazonium.	Approved
Roxithromycin	The metabolism of Roxithromycin can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Rucaparib	The metabolism of Rucaparib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Rupatadine	The metabolism of Rupatadine can be decreased when combined with Isavuconazonium.	Approved
Ruxolitinib	The metabolism of Ruxolitinib can be decreased when combined with Isavuconazonium.	Approved
Safinamide	The metabolism of Safinamide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Salmeterol	The serum concentration of Salmeterol can be increased when it is combined with Isavuconazonium.	Approved
Saquinavir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Saquinavir.	Approved, Investigational
Sarilumab	The therapeutic efficacy of Isavuconazonium can be decreased when used in combination with Sarilumab.	Approved, Investigational
Saxagliptin	The serum concentration of Saxagliptin can be increased when it is combined with Isavuconazonium.	Approved
Selegiline	The metabolism of Selegiline can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Selexipag	The metabolism of Selexipag can be decreased when combined with Isavuconazonium.	Approved
Seratrodast	The metabolism of Seratrodast can be decreased when combined with Isavuconazonium.	Approved
Sertindole	The metabolism of Sertindole can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Sertraline	The metabolism of Sertraline can be decreased when combined with Isavuconazonium.	Approved
Sevoflurane	The metabolism of Sevoflurane can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Sibutramine	The metabolism of Sibutramine can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational, Withdrawn
Sildenafil	The metabolism of Isavuconazonium can be decreased when combined with Sildenafil.	Approved, Investigational
Silodosin	The serum concentration of Silodosin can be increased when it is combined with Isavuconazonium.	Approved
Siltuximab	The serum concentration of Isavuconazonium can be decreased when it is combined with Siltuximab.	Approved, Investigational
Simeprevir	The serum concentration of Isavuconazonium can be increased when it is combined with Simeprevir.	Approved
Simvastatin	The serum concentration of Simvastatin can be increased when it is combined with Isavuconazonium.	Approved
Sirolimus	The metabolism of Sirolimus can be decreased when combined with Isavuconazonium.	Approved, Investigational
Sitagliptin	The metabolism of Sitagliptin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Solifenacin	The metabolism of Solifenacin can be decreased when combined with Isavuconazonium.	Approved
Sonidegib	The serum concentration of Sonidegib can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Sorafenib	The metabolism of Sorafenib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Spiramycin	The metabolism of Spiramycin can be decreased when combined with Isavuconazonium.	Approved
St. John's Wort	The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with St. John's Wort resulting in a loss in efficacy.	Approved, Investigational, Nutraceutical
Stiripentol	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Stiripentol.	Approved
Sufentanil	The metabolism of Sufentanil can be decreased when combined with Isavuconazonium.	Approved, Investigational
Sulfadiazine	The metabolism of Sulfadiazine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Sulfamethoxazole	The metabolism of Sulfamethoxazole can be decreased when combined with Isavuconazonium.	Approved
Sulfinpyrazone	The metabolism of Sulfinpyrazone can be decreased when combined with Isavuconazonium.	Approved
Sulfisoxazole	The metabolism of Isavuconazonium can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sunitinib	The metabolism of Sunitinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Suvorexant	The serum concentration of Suvorexant can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Synthetic Conjugated Estrogens, A	The metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Isavuconazonium.	Approved
Synthetic Conjugated Estrogens, B	The metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Isavuconazonium.	Approved
Tacrolimus	The metabolism of Tacrolimus can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tadalafil	The metabolism of Tadalafil can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tamoxifen	The metabolism of Tamoxifen can be decreased when combined with Isavuconazonium.	Approved
Tamsulosin	The metabolism of Tamsulosin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tasosartan	The metabolism of Tasosartan can be decreased when combined with Isavuconazonium.	Approved
Taurochenodeoxycholic acid	The metabolism of Taurochenodeoxycholic acid can be decreased when combined with Isavuconazonium.	Experimental
Telaprevir	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir.	Approved, Withdrawn
Telithromycin	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin.	Approved
Temazepam	The metabolism of Temazepam can be decreased when combined with Isavuconazonium.	Approved, Investigational
Temsirolimus	The metabolism of Temsirolimus can be decreased when combined with Isavuconazonium.	Approved
Teniposide	The metabolism of Teniposide can be decreased when combined with Isavuconazonium.	Approved
Terbinafine	The metabolism of Terbinafine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Terfenadine	The metabolism of Terfenadine can be decreased when combined with Isavuconazonium.	Approved, Withdrawn
Terguride	The risk or severity of adverse effects can be increased when Terguride is combined with Isavuconazonium.	Experimental
Tesmilifene	The metabolism of Tesmilifene can be decreased when combined with Isavuconazonium.	Investigational
Testosterone	The metabolism of Testosterone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Testosterone cypionate	The metabolism of Testosterone cypionate can be decreased when combined with Isavuconazonium.	Approved
Testosterone enanthate	The metabolism of Testosterone enanthate can be decreased when combined with Isavuconazonium.	Approved
Testosterone propionate	The metabolism of Testosterone propionate can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoate	The metabolism of Testosterone undecanoate can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tetracycline	The metabolism of Tetracycline can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Tezacaftor	The metabolism of Tezacaftor can be decreased when combined with Isavuconazonium.	Approved, Investigational
Theophylline	The metabolism of Theophylline can be decreased when combined with Isavuconazonium.	Approved
Thiotepa	The metabolism of Thiotepa can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tiagabine	The metabolism of Tiagabine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ticagrelor	The metabolism of Ticagrelor can be decreased when combined with Isavuconazonium.	Approved
Ticlopidine	The metabolism of Isavuconazonium can be decreased when combined with Ticlopidine.	Approved
Tinidazole	The metabolism of Tinidazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tiotropium	The metabolism of Tiotropium can be decreased when combined with Isavuconazonium.	Approved
Tipranavir	The metabolism of Tipranavir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tocilizumab	The serum concentration of Isavuconazonium can be decreased when it is combined with Tocilizumab.	Approved
Tocopherol	The metabolism of Tocopherol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tofacitinib	The metabolism of Tofacitinib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tolterodine	The metabolism of Tolterodine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Isavuconazonium.	Approved
Topotecan	The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Toremifene	The metabolism of Toremifene can be decreased when combined with Isavuconazonium.	Approved, Investigational
Trabectedin	The metabolism of Trabectedin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tramadol	The metabolism of Tramadol can be decreased when combined with Isavuconazonium.	Approved, Investigational
Trastuzumab emtansine	The metabolism of Trastuzumab emtansine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Trazodone	The metabolism of Trazodone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Tretinoin	The metabolism of Tretinoin can be decreased when combined with Isavuconazonium.	Approved, Investigational, Nutraceutical
Triamcinolone	The metabolism of Triamcinolone can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Triazolam	The metabolism of Triazolam can be decreased when combined with Isavuconazonium.	Approved, Investigational
Trimethadione	The metabolism of Trimethadione can be decreased when combined with Isavuconazonium.	Approved
Trimethoprim	The metabolism of Trimethoprim can be decreased when combined with Isavuconazonium.	Approved, Vet Approved
Trimipramine	The metabolism of Trimipramine can be decreased when combined with Isavuconazonium.	Approved
Troglitazone	The metabolism of Troglitazone can be decreased when combined with Isavuconazonium.	Investigational, Withdrawn
Troleandomycin	The metabolism of Troleandomycin can be decreased when combined with Isavuconazonium.	Approved
Udenafil	The metabolism of Udenafil can be decreased when combined with Isavuconazonium.	Approved, Investigational
Ulipristal	The serum concentration of Ulipristal can be increased when it is combined with Isavuconazonium.	Approved
Valbenazine	The metabolism of Valbenazine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Valdecoxib	The metabolism of Valdecoxib can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Vandetanib	The metabolism of Vandetanib can be decreased when combined with Isavuconazonium.	Approved
Vanoxerine	The metabolism of Vanoxerine can be decreased when combined with Isavuconazonium.	Investigational
Vardenafil	The metabolism of Vardenafil can be decreased when combined with Isavuconazonium.	Approved
Velpatasvir	The metabolism of Velpatasvir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Vemurafenib	The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Isavuconazonium.	Approved
Venetoclax	The metabolism of Venetoclax can be decreased when combined with Isavuconazonium.	Approved, Investigational
Venlafaxine	The metabolism of Isavuconazonium can be decreased when combined with Venlafaxine.	Approved
Verapamil	The metabolism of Isavuconazonium can be decreased when combined with Verapamil.	Approved
Vicriviroc	The metabolism of Vicriviroc can be decreased when combined with Isavuconazonium.	Investigational
Vilanterol	The metabolism of Vilanterol can be decreased when combined with Isavuconazonium.	Approved
Vilazodone	The serum concentration of Vilazodone can be increased when it is combined with Isavuconazonium.	Approved
Vinblastine	The metabolism of Vinblastine can be decreased when combined with Isavuconazonium.	Approved
Vincristine	The metabolism of Vincristine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Vindesine	The serum concentration of Vindesine can be increased when it is combined with Isavuconazonium.	Approved, Investigational
Vinorelbine	The metabolism of Vinorelbine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Vismodegib	The metabolism of Vismodegib can be decreased when combined with Isavuconazonium.	Approved, Investigational
Voriconazole	The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Voriconazole.	Approved, Investigational
Vortioxetine	The metabolism of Vortioxetine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Voxilaprevir	The metabolism of Voxilaprevir can be decreased when combined with Isavuconazonium.	Approved, Investigational
Warfarin	The metabolism of Warfarin can be decreased when combined with Isavuconazonium.	Approved
Yohimbine	The metabolism of Yohimbine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Vet Approved
Zafirlukast	The metabolism of Zafirlukast can be decreased when combined with Isavuconazonium.	Approved, Investigational
Zalcitabine	The metabolism of Zalcitabine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Zaleplon	The metabolism of Zaleplon can be decreased when combined with Isavuconazonium.	Approved, Illicit, Investigational
Zidovudine	The metabolism of Zidovudine can be decreased when combined with Isavuconazonium.	Approved
Zileuton	The metabolism of Zileuton can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Ziprasidone	The metabolism of Isavuconazonium can be decreased when combined with Ziprasidone.	Approved
Zolpidem	The metabolism of Zolpidem can be decreased when combined with Isavuconazonium.	Approved
Zomepirac	The metabolism of Zomepirac can be decreased when combined with Isavuconazonium.	Withdrawn
Zonisamide	The metabolism of Zonisamide can be decreased when combined with Isavuconazonium.	Approved, Investigational
Zopiclone	The serum concentration of Zopiclone can be increased when it is combined with Isavuconazonium.	Approved
Zotepine	The metabolism of Zotepine can be decreased when combined with Isavuconazonium.	Approved, Investigational, Withdrawn
Zuclopenthixol	The serum concentration of Zuclopenthixol can be increased when it is combined with Isavuconazonium.	Approved, Investigational

Food Interactions

Not Available

References

General References

1. Rybak JM, Marx KR, Nishimoto AT, Rogers PD: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. doi: 10.1002/phar.1652. Epub 2015 Nov 2. [PubMed:26598096]
2. Miceli MH, Kauffman CA: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis. 2015 Nov 15;61(10):1558-65. doi: 10.1093/cid/civ571. Epub 2015 Jul 15. [PubMed:26179012]

External Links

KEGG Drug

D10643

PubChem Compound

6918606

PubChem Substance

310264875

ChemSpider

5293801

ChEBI

85978

ChEMBL

CHEMBL1183349

Wikipedia

Isavuconazole

FDA label

Download (851 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
1	Completed	Not Available	Healthy Adult Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Ketoconazole	1
1	Completed	Not Available	Healthy Volunteers	1
1	Completed	Not Available	Healthy Volunteers / Pharmacodynamics of Warfarin / Pharmacokinetics of Isavuconazole / Pharmacokinetics of S- and R-warfarin	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of 14C-labeled Isavuconazonium Sulfate	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of 7-hydroxymethotrexate / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Methotrexate	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Atorvastatin / Pharmacokinetics of Isavuconazole	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of BAL4815 / Pharmacokinetics of BAL8728	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Bupropion / Pharmacokinetics of Isavuconazole	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Digoxin / Pharmacokinetics of Isavuconazole	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Ethinyl Estradiol and Norethindrone / Pharmacokinetics of Isavuconazole	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Lopinavir/Ritonavir	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Metformin	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Methadone	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Midazolam	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Prednisolone	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Sirolimus	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Tacrolimus	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Renal Impaired	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Safety and Tolerability in Elderly	1
1	Recruiting	Treatment	Haematological Malignancies	1
2	Recruiting	Treatment	Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
2	Recruiting	Treatment	Malignancies, Hematologic / Myeloproliferative Disorders	1
2, 3	Completed	Prevention	Leukemia Acute Myeloid Leukemia (AML)	1
3	Completed	Treatment	Aspergillosis / Invasive Fungal Infections	2
3	Completed	Treatment	Candidemia / Candidiasis, Invasive / Mycoses	1
Not Available	Recruiting	Not Available	Invasive Fungal Infections	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Form	Route	Strength
Capsule	Oral	186 mg/1
Injection, powder, lyophilized, for solution	Intravenous	74.4 mg/mL

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US7459561	No	2000-10-31	2020-10-31
US6812238	No	2000-10-31	2020-10-31

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.00516 mg/mL	ALOGPS
logP	1.73	ALOGPS
logP	0.52	ChemAxon
logS	-5.2	ALOGPS
pKa (Strongest Acidic)	12.57	ChemAxon
pKa (Strongest Basic)	6.45	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	159.37 Å2	ChemAxon
Rotatable Bond Count	15	ChemAxon
Refractivity	193.86 m3·mol-1	ChemAxon
Polarizability	71.63 Å3	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acid esters

Alternative Parents

Phenylpropanes / Benzonitriles / Fluorobenzenes / 2,4-disubstituted thiazoles / Imidolactams / Pyridines and derivatives / Aryl fluorides / Triazoles / Heteroaromatic compounds / Carbamate estersTertiary alcohols / Carboxylic acid esters / Organic carbonic acids and derivatives / Dialkylamines / Monocarboxylic acids and derivatives / Nitriles / Azacyclic compounds / Organopnictogen compounds / Carbonyl compounds / Hydrocarbon derivatives / Organic oxides / Organofluorides / Aromatic alcohols / Organic cations

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Substituents

Alpha-amino acid ester / Phenylpropane / Benzonitrile / 2,4-disubstituted 1,3-thiazole / Fluorobenzene / Halobenzene / Aryl fluoride / Aryl halide / Pyridine / ImidolactamBenzenoid / Monocyclic benzene moiety / Azole / Heteroaromatic compound / Carbamic acid ester / 1,2,4-triazole / Thiazole / Tertiary alcohol / Carboxylic acid ester / Carbonic acid derivative / Secondary aliphatic amine / Secondary amine / Organoheterocyclic compound / Azacycle / Nitrile / Carbonitrile / Monocarboxylic acid or derivatives / Organic nitrogen compound / Alcohol / Organohalogen compound / Organofluoride / Organonitrogen compound / Organooxygen compound / Carbonyl group / Aromatic alcohol / Hydrocarbon derivative / Organic oxide / Organopnictogen compound / Amine / Organic oxygen compound / Organic cation / Aromatic heteromonocyclic compound

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Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

organic cation (CHEBI:85978)

Drug created on March 19, 2008 10:42 / Updated on March 02, 2018 05:15