Identification

Name
Isavuconazonium
Accession Number
DB06636
Type
Small Molecule
Groups
Approved, Investigational
Description

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and parenteral formulations. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. This formulation also avoids the use of a cyclodextrin vehicle for solubilization required for intravenous administration of other antifungals such as voriconazole and posaconazole, eliminating concerns of nephrotoxicity associated with cyclodextrin. Isovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market.

Structure
Thumb
Synonyms
Not Available
External IDs
BAL-8557 / BAL8557
Product Ingredients
IngredientUNIICASInChI Key
Isavuconazonium sulfate31Q44514JV946075-13-4LWXUIUUOMSMZKJ-KLFWAVJMSA-M
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CresembaInjection, powder, lyophilized, for solution74.4 mg/mLIntravenousAstellas Pharma Inc2015-03-06Not applicableUs
CresembaCapsule186 mg/1OralAstellas Pharma Inc2015-11-04Not applicableUs
CresembaCapsule186 mg/1OralAstellas Pharma Inc2015-03-062016-12-31Us
Categories
UNII
VH2L779W8Q
CAS number
742049-41-8
Weight
Average: 717.77
Monoisotopic: 717.241370179
Chemical Formula
C35H35F2N8O5S
InChI Key
RSWOJTICKMKTER-QXLBVTBOSA-N
InChI
InChI=1S/C35H35F2N8O5S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3/q+1/t22-,23?,35+/m0/s1
IUPAC Name
1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium
SMILES
[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[[email protected]](O)(C2=C(F)C=CC(F)=C2)[[email protected]@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1

Pharmacology

Indication

Indicated in the treatment of invasive aspergillosis and invasive mucormycosis.

Structured Indications
Pharmacodynamics
Not Available
Mechanism of action

Antifungals in the triazole class, such as isavuconazonium, target and inhibit the sterol 14-α-demethylase (Erg11p) which is a key player in the demethylation step of the ergosterol biosynthetic pathway. This inhibition results in a halt in production of ergosterol, a molecule typically found in the membranes of fungi such as Aspergillus, Candida, and Mucorales that plays a role in regulation of membrane integrity, fluidity and permeability. The inhibition of Erg11p also causes the buildup of ergosterol precursors, which are toxic and cause cell death.

Absorption

When administered intravenously as isavuconazonium, >99% of the prodrug is quickly converted to active isavuconazole (catalyzed by plasma esterases). Oral administration of isavuconazonium shows 98% oral bioavailability, however administration with food results in a 20% decrease in AUC (area under concentration-time curve) as well as decreasing maximum serum concentration (Cmax) by 50% and increasing time to Cmax by 1.5 hours.

Volume of distribution

450 L

Protein binding

>99%

Metabolism

Metabolism is primarily hepatic, with CYP3A4 and CYP3A5 involved in phase I metabolism, followed by modification by uridine diphosphate glucuronosyltransferase (UGT).

Route of elimination

45% excreted in feces and bile, and 45% excreted in urine as inactive metabolites. Less than 1% of active isavuconazole is excreted unchanged in urine.

Half life

80 to 130 hours.

Clearance
Not Available
Toxicity

Isavuconazole, the active moiety of isavuconazonium, is classified as Pregnancy Class C and should be avoided in pregnant women. It was also found to be excreted in breast milk in animal studies in rats, therefore it should be avoided in breastfeeding women.

Affected organisms
  • Candida albicans and other yeasts
  • Aspergillis, Candida and other fungi
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Isavuconazonium.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Isavuconazonium.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Isavuconazonium.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Isavuconazonium.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Isavuconazonium.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Isavuconazonium.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Isavuconazonium.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Isavuconazonium.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Isavuconazonium.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Isavuconazonium.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Isavuconazonium.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Isavuconazonium.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Isavuconazonium.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Isavuconazonium.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Isavuconazonium.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Isavuconazonium.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Isavuconazonium.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Isavuconazonium.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Isavuconazonium.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Isavuconazonium.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Isavuconazonium.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Isavuconazonium.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Isavuconazonium.Approved
AmiodaroneThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Isavuconazonium.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Isavuconazonium.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Isavuconazonium.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Isavuconazonium.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Isavuconazonium.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Isavuconazonium.Approved, Investigational
AprepitantThe serum concentration of Isavuconazonium can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Isavuconazonium.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Isavuconazonium.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Isavuconazonium.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Isavuconazonium.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Isavuconazonium.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Isavuconazonium.Approved, Withdrawn
AtazanavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Isavuconazonium.Approved
AtomoxetineThe metabolism of Isavuconazonium can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Isavuconazonium is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Isavuconazonium.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Isavuconazonium.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Isavuconazonium.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Isavuconazonium.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Isavuconazonium.Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Isavuconazonium.Approved
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Isavuconazonium.Approved, Investigational
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Isavuconazonium.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Isavuconazonium.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Isavuconazonium.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Isavuconazonium.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Isavuconazonium.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Isavuconazonium.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Isavuconazonium.Approved
BoceprevirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir.Withdrawn
BortezomibThe metabolism of Isavuconazonium can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Isavuconazonium.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Isavuconazonium.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Isavuconazonium.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Isavuconazonium.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Isavuconazonium.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Isavuconazonium.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Isavuconazonium.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Isavuconazonium.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Isavuconazonium.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Isavuconazonium.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Isavuconazonium.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Isavuconazonium.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Isavuconazonium.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Isavuconazonium.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Isavuconazonium.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Isavuconazonium.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Isavuconazonium.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Isavuconazonium.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Isavuconazonium.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Isavuconazonium.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Isavuconazonium.Approved
CarbamazepineThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Carbamazepine resulting in a loss in efficacy.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Isavuconazonium.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Isavuconazonium.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Isavuconazonium.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Isavuconazonium.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Isavuconazonium.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Isavuconazonium.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Isavuconazonium.Approved, Vet Approved
CeritinibThe serum concentration of Isavuconazonium can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Isavuconazonium.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Isavuconazonium.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Isavuconazonium.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Isavuconazonium.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Isavuconazonium.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Isavuconazonium.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Isavuconazonium.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Isavuconazonium.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Isavuconazonium.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Isavuconazonium.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Isavuconazonium.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Isavuconazonium.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Isavuconazonium.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Isavuconazonium.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Isavuconazonium.Approved
ClarithromycinThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Clarithromycin.Approved
ClemastineThe metabolism of Isavuconazonium can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Isavuconazonium.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Isavuconazonium.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Isavuconazonium.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Isavuconazonium.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Isavuconazonium.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Isavuconazonium.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Isavuconazonium.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Isavuconazonium.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
ClotrimazoleThe metabolism of Isavuconazonium can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Isavuconazonium.Approved
CobicistatThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Isavuconazonium.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Isavuconazonium.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Isavuconazonium.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Isavuconazonium.Approved
ConivaptanThe serum concentration of Isavuconazonium can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Isavuconazonium.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Isavuconazonium.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Isavuconazonium.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Isavuconazonium.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Isavuconazonium.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Isavuconazonium.Approved, Investigational
CyclosporineThe metabolism of Isavuconazonium can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Isavuconazonium.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Isavuconazonium.Approved
DabrafenibThe serum concentration of Isavuconazonium can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Isavuconazonium.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Isavuconazonium.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Isavuconazonium.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Isavuconazonium.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Isavuconazonium.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Isavuconazonium.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Isavuconazonium.Approved, Investigational
DarunavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Isavuconazonium.Approved
DasatinibThe serum concentration of Isavuconazonium can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Isavuconazonium.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Isavuconazonium.Approved
DeferasiroxThe serum concentration of Isavuconazonium can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Isavuconazonium.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Isavuconazonium.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Isavuconazonium.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Isavuconazonium.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Isavuconazonium.Approved
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Isavuconazonium.Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Isavuconazonium.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Isavuconazonium.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Isavuconazonium.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Isavuconazonium.Approved, Vet Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Isavuconazonium.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Isavuconazonium.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Isavuconazonium.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Isavuconazonium.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Isavuconazonium.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Isavuconazonium.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Isavuconazonium.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Isavuconazonium.Experimental
DihydroergotamineThe metabolism of Isavuconazonium can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Isavuconazonium.Illicit
DiltiazemThe metabolism of Isavuconazonium can be decreased when combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Isavuconazonium.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Isavuconazonium.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Isavuconazonium.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Isavuconazonium.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Isavuconazonium.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Isavuconazonium.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Isavuconazonium.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Isavuconazonium.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Isavuconazonium.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Isavuconazonium.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Isavuconazonium.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Isavuconazonium.Approved, Investigational
DoxycyclineThe metabolism of Isavuconazonium can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Isavuconazonium.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Isavuconazonium.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Isavuconazonium.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Isavuconazonium.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Isavuconazonium.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Isavuconazonium.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Isavuconazonium.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Isavuconazonium.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Isavuconazonium.Approved, Vet Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Isavuconazonium.Approved
EnzalutamideThe serum concentration of Isavuconazonium can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Isavuconazonium.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Isavuconazonium.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Isavuconazonium.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Isavuconazonium.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Isavuconazonium.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Isavuconazonium.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Isavuconazonium.Approved, Investigational
ErythromycinThe metabolism of Isavuconazonium can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Isavuconazonium.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Isavuconazonium.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Isavuconazonium.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Isavuconazonium.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Isavuconazonium.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Isavuconazonium.Approved, Vet Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Isavuconazonium.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Isavuconazonium.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Isavuconazonium.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Isavuconazonium.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Isavuconazonium.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Isavuconazonium.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Isavuconazonium.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Isavuconazonium.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Isavuconazonium.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Isavuconazonium.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Isavuconazonium.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Isavuconazonium.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Isavuconazonium.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Isavuconazonium.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Isavuconazonium.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Isavuconazonium.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Isavuconazonium.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Isavuconazonium.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Isavuconazonium.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Isavuconazonium.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Isavuconazonium.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Isavuconazonium.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Isavuconazonium.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Isavuconazonium.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Isavuconazonium.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Isavuconazonium.Approved
FluconazoleThe metabolism of Isavuconazonium can be decreased when combined with Fluconazole.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Isavuconazonium.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Isavuconazonium.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Isavuconazonium.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Isavuconazonium.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be decreased when combined with Isavuconazonium.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Isavuconazonium.Approved
FluvoxamineThe metabolism of Isavuconazonium can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Isavuconazonium.Approved
FosaprepitantThe serum concentration of Isavuconazonium can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Fosphenytoin resulting in a loss in efficacy.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Isavuconazonium.Approved, Investigational
Fusidic AcidThe serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Isavuconazonium.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Isavuconazonium.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Isavuconazonium.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Isavuconazonium.Approved
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Isavuconazonium.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Isavuconazonium.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Isavuconazonium.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Isavuconazonium.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Isavuconazonium.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Isavuconazonium.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Isavuconazonium.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Isavuconazonium.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Isavuconazonium.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Isavuconazonium.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Isavuconazonium.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Isavuconazonium.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Isavuconazonium.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Isavuconazonium.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Isavuconazonium.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Isavuconazonium.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Isavuconazonium.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Isavuconazonium.Approved, Investigational
IdelalisibThe serum concentration of Isavuconazonium can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Isavuconazonium resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Isavuconazonium.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Isavuconazonium.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Isavuconazonium.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Isavuconazonium.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Isavuconazonium.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Isavuconazonium.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Isavuconazonium.Approved
IndinavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Isavuconazonium.Approved, Investigational
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Isavuconazonium.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Isavuconazonium.Approved
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Isavuconazonium.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Isavuconazonium.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Isavuconazonium.Approved
IsradipineThe metabolism of Isavuconazonium can be decreased when combined with Isradipine.Approved
ItraconazoleThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Isavuconazonium.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Isavuconazonium.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Isavuconazonium.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Isavuconazonium.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Isavuconazonium.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Isavuconazonium.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Isavuconazonium.Approved
KetoconazoleThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Isavuconazonium.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Isavuconazonium.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Isavuconazonium.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Isavuconazonium.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Isavuconazonium.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Isavuconazonium.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Isavuconazonium.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Isavuconazonium.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Isavuconazonium.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Isavuconazonium.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Isavuconazonium.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Isavuconazonium.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Isavuconazonium.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Isavuconazonium.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Isavuconazonium.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Isavuconazonium.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Isavuconazonium.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Isavuconazonium.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Isavuconazonium.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Isavuconazonium.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Isavuconazonium.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Isavuconazonium.Approved
LopinavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Isavuconazonium.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Isavuconazonium.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Isavuconazonium.Approved
LovastatinThe metabolism of Isavuconazonium can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Isavuconazonium can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Lumacaftor resulting in a loss in efficacy.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Isavuconazonium.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Isavuconazonium.Approved
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Isavuconazonium.Illicit, Withdrawn
MacitentanThe metabolism of Macitentan can be decreased when combined with Isavuconazonium.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Isavuconazonium.Approved, Investigational
MaravirocThe metabolism of Maraviroc can be decreased when combined with Isavuconazonium.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Isavuconazonium.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Isavuconazonium.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Isavuconazonium.Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Isavuconazonium.Approved, Vet Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Isavuconazonium.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Isavuconazonium.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Isavuconazonium.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Isavuconazonium.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Isavuconazonium.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Isavuconazonium.Approved, Vet Approved
Methyl salicylateThe metabolism of Methyl salicylate can be decreased when combined with Isavuconazonium.Approved, Vet Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Isavuconazonium.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Isavuconazonium.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Isavuconazonium.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Isavuconazonium.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Isavuconazonium.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Isavuconazonium.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Isavuconazonium.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Isavuconazonium.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Isavuconazonium.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Isavuconazonium.Approved, Illicit
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Isavuconazonium.Approved
MifepristoneThe serum concentration of Isavuconazonium can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Isavuconazonium.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Isavuconazonium.Approved
MitotaneThe serum concentration of Isavuconazonium can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Isavuconazonium.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Isavuconazonium.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Isavuconazonium.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Isavuconazonium.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Isavuconazonium.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be increased when it is combined with Isavuconazonium.Approved
NadololThe serum concentration of Nadolol can be increased when it is combined with Isavuconazonium.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Isavuconazonium.Approved, Investigational
NefazodoneThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nelfinavir.Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Isavuconazonium.Approved, Investigational
NetupitantThe serum concentration of Isavuconazonium can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Nevirapine resulting in a loss in efficacy.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Isavuconazonium.Approved
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Isavuconazonium.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Isavuconazonium.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Isavuconazonium.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Isavuconazonium.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Isavuconazonium.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Isavuconazonium.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Isavuconazonium.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Isavuconazonium.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Isavuconazonium.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Isavuconazonium.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Isavuconazonium.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Isavuconazonium.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Isavuconazonium.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Isavuconazonium.Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Isavuconazonium.Investigational
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Isavuconazonium.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Isavuconazonium.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Isavuconazonium.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Isavuconazonium.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Isavuconazonium.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Isavuconazonium.Approved
OsimertinibThe serum concentration of Isavuconazonium can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Isavuconazonium.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Isavuconazonium.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Isavuconazonium.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Isavuconazonium is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Isavuconazonium.Approved, Vet Approved
PalbociclibThe serum concentration of Isavuconazonium can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Isavuconazonium.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Isavuconazonium.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Isavuconazonium.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Isavuconazonium.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Isavuconazonium.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Isavuconazonium.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Isavuconazonium.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Isavuconazonium.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Isavuconazonium.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Isavuconazonium.Approved
PentobarbitalThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Pentobarbital resulting in a loss in efficacy.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Isavuconazonium.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Isavuconazonium.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Isavuconazonium.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Isavuconazonium.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Isavuconazonium.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Isavuconazonium.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Isavuconazonium.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Isavuconazonium.Withdrawn
PhenobarbitalThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenobarbital resulting in a loss in efficacy.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Isavuconazonium.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Isavuconazonium.Approved
PhenytoinThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenytoin resulting in a loss in efficacy.Approved, Vet Approved
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Isavuconazonium.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Isavuconazonium.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Isavuconazonium.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Isavuconazonium.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Isavuconazonium.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Isavuconazonium.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Isavuconazonium.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Isavuconazonium.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Isavuconazonium.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Isavuconazonium.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Isavuconazonium.Approved
PosaconazoleThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Isavuconazonium.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Isavuconazonium.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Isavuconazonium.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Isavuconazonium.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Isavuconazonium.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Isavuconazonium.Approved
PrimidoneThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Primidone resulting in a loss in efficacy.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Isavuconazonium.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Isavuconazonium.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be decreased when combined with Isavuconazonium.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Isavuconazonium.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Isavuconazonium.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Isavuconazonium.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Isavuconazonium.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Isavuconazonium.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Isavuconazonium.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Isavuconazonium.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Isavuconazonium.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Isavuconazonium.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Isavuconazonium.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Isavuconazonium.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Isavuconazonium.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Isavuconazonium.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Isavuconazonium.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Isavuconazonium.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Isavuconazonium.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Isavuconazonium.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Isavuconazonium.Approved
RifabutinThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy.Approved
RifampicinThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.Approved
RifapentineThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifapentine resulting in a loss in efficacy.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Isavuconazonium.Approved, Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Isavuconazonium.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Isavuconazonium.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Isavuconazonium.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Isavuconazonium.Approved, Investigational
RitonavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Isavuconazonium.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Isavuconazonium.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Isavuconazonium.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Isavuconazonium.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Isavuconazonium.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Isavuconazonium.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Isavuconazonium.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Isavuconazonium.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Isavuconazonium.Approved, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Isavuconazonium.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Isavuconazonium.Approved
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Isavuconazonium.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Isavuconazonium.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Isavuconazonium.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Isavuconazonium.Approved
SaquinavirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Isavuconazonium.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Isavuconazonium.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Isavuconazonium.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Isavuconazonium.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Isavuconazonium.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Isavuconazonium.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Isavuconazonium.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Isavuconazonium can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Isavuconazonium.Approved
SiltuximabThe serum concentration of Isavuconazonium can be decreased when it is combined with Siltuximab.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Isavuconazonium.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Isavuconazonium.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Isavuconazonium.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Isavuconazonium.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Isavuconazonium.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Isavuconazonium.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Isavuconazonium.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Isavuconazonium.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Isavuconazonium.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Isavuconazonium.Approved
St. John's WortThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with St. John's Wort resulting in a loss in efficacy.Nutraceutical
StiripentolThe serum concentration of Isavuconazonium can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Isavuconazonium.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Isavuconazonium.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Isavuconazonium.Approved
SulfisoxazoleThe metabolism of Isavuconazonium can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Isavuconazonium.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Isavuconazonium.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Isavuconazonium.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Isavuconazonium.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Isavuconazonium.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Isavuconazonium.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Isavuconazonium.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Isavuconazonium.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Isavuconazonium.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Isavuconazonium.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Isavuconazonium.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Isavuconazonium.Approved
TelaprevirThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir.Withdrawn
TelithromycinThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Isavuconazonium.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Isavuconazonium.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Isavuconazonium.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Isavuconazonium.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Isavuconazonium.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Isavuconazonium.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Isavuconazonium.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Isavuconazonium.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Isavuconazonium.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Isavuconazonium.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Isavuconazonium.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Isavuconazonium.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Isavuconazonium.Approved
TiclopidineThe metabolism of Isavuconazonium can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Isavuconazonium.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Isavuconazonium.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Isavuconazonium.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Isavuconazonium.Approved, Investigational
TocilizumabThe serum concentration of Isavuconazonium can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Isavuconazonium.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be decreased when combined with Isavuconazonium.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Isavuconazonium.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Isavuconazonium.Approved, Investigational
ToremifeneThe metabolism of Toremifene can be decreased when combined with Isavuconazonium.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Isavuconazonium.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Isavuconazonium.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Isavuconazonium.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Isavuconazonium.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Isavuconazonium.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Isavuconazonium.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Isavuconazonium.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Isavuconazonium.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Isavuconazonium.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Isavuconazonium.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Isavuconazonium.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Isavuconazonium.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Isavuconazonium.Experimental
UdenafilThe metabolism of Udenafil can be decreased when combined with Isavuconazonium.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Isavuconazonium.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Isavuconazonium.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Isavuconazonium.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Isavuconazonium.Investigational, Withdrawn
VandetanibThe metabolism of Vandetanib can be decreased when combined with Isavuconazonium.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Isavuconazonium.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Isavuconazonium.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Isavuconazonium.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Isavuconazonium.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Isavuconazonium.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Isavuconazonium.Approved
VenlafaxineThe metabolism of Isavuconazonium can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Isavuconazonium.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Isavuconazonium.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Isavuconazonium.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Isavuconazonium.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Isavuconazonium.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Isavuconazonium.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Isavuconazonium.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Isavuconazonium.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Isavuconazonium.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Isavuconazonium.Approved
VoriconazoleThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Isavuconazonium.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Isavuconazonium.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Isavuconazonium.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Isavuconazonium.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Isavuconazonium.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Isavuconazonium.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Isavuconazonium.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Isavuconazonium.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Isavuconazonium.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Isavuconazonium can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Isavuconazonium.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Isavuconazonium.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Isavuconazonium.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Isavuconazonium.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Isavuconazonium.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Rybak JM, Marx KR, Nishimoto AT, Rogers PD: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. doi: 10.1002/phar.1652. Epub 2015 Nov 2. [PubMed:26598096]
  2. Miceli MH, Kauffman CA: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis. 2015 Nov 15;61(10):1558-65. doi: 10.1093/cid/civ571. Epub 2015 Jul 15. [PubMed:26179012]
External Links
KEGG Drug
D10643
ChemSpider
5293801
ChEBI
85978
ChEMBL
CHEMBL1183349
Wikipedia
Isavuconazole
FDA label
Download (851 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Adult Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Ketoconazole1
1CompletedNot AvailableHealthy Volunteers1
1CompletedNot AvailableHealthy Volunteers / Pharmacodynamics of Warfarin / Pharmacokinetics of Isavuconazole / Pharmacokinetics of S- and R-warfarin1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of 14C-labeled Isavuconazonium Sulfate1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of 7-hydroxymethotrexate / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Methotrexate1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Atorvastatin / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of BAL4815 / Pharmacokinetics of BAL87281
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Bupropion / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Digoxin / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Ethinyl Estradiol and Norethindrone / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Lopinavir/Ritonavir1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Metformin1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Methadone1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Midazolam1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Prednisolone1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Sirolimus1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Tacrolimus1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Renal Impaired1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Safety and Tolerability in Elderly1
1RecruitingTreatmentHaematological Malignancies1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
2RecruitingTreatmentMalignancies, Hematologic / Myeloproliferative Disorders1
2, 3CompletedPreventionLeukemia Acute Myeloid Leukemia (AML)1
3CompletedTreatmentAspergillosis / Invasive Fungal Infections2
3CompletedTreatmentCandidemia / Candidiasis, Invasive / Mycoses1
Not AvailableRecruitingNot AvailableInvasive Fungal Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral186 mg/1
Injection, powder, lyophilized, for solutionIntravenous74.4 mg/mL
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7459561No2000-10-312020-10-31Us
US6812238No2000-10-312020-10-31Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00516 mg/mLALOGPS
logP1.73ALOGPS
logP0.52ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)12.57ChemAxon
pKa (Strongest Basic)6.45ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area159.37 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity193.86 m3·mol-1ChemAxon
Polarizability71.63 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acid esters
Alternative Parents
Phenylpropanes / Benzonitriles / Fluorobenzenes / 2,4-disubstituted thiazoles / Imidolactams / Pyridines and derivatives / Aryl fluorides / Triazoles / Heteroaromatic compounds / Carbamate esters
show 14 more
Substituents
Alpha-amino acid ester / Phenylpropane / Benzonitrile / 2,4-disubstituted 1,3-thiazole / Fluorobenzene / Halobenzene / Aryl fluoride / Aryl halide / Pyridine / Imidolactam
show 32 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
organic cation (CHEBI:85978)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Rybak JM, Marx KR, Nishimoto AT, Rogers PD: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. doi: 10.1002/phar.1652. Epub 2015 Nov 2. [PubMed:26598096]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Miceli MH, Kauffman CA: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis. 2015 Nov 15;61(10):1558-65. doi: 10.1093/cid/civ571. Epub 2015 Jul 15. [PubMed:26179012]

Drug created on March 19, 2008 10:42 / Updated on October 02, 2017 05:45