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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyIsavuconazonium
Identification
- Name
- Isavuconazonium
- Accession Number
- DB06636
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Description
Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and parenteral formulations. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. This formulation also avoids the use of a cyclodextrin vehicle for solubilization required for intravenous administration of other antifungals such as voriconazole and posaconazole, eliminating concerns of nephrotoxicity associated with cyclodextrin. Isovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market.
- Structure
Structure for DB06636 (Isavuconazonium)
- Synonyms
- Not Available
- External IDs
- BAL-8557 / BAL8557
- Product Ingredients
Ingredient UNII CAS InChI Key Isavuconazonium sulfate 31Q44514JV 946075-13-4 LWXUIUUOMSMZKJ-KLFWAVJMSA-M - Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Cresemba Capsule 186 mg/1 Oral Astellas Pharma Inc 2015-03-06 2016-12-31 US 
Cresemba Capsule 186 mg/1 Oral Astellas Pharma Inc 2015-11-04 Not applicable US Cresemba Injection, powder, lyophilized, for solution 74.4 mg/mL Intravenous Astellas Pharma Inc 2015-03-06 Not applicable US - Categories
- UNII
- VH2L779W8Q
- CAS number
- 742049-41-8
- Weight
- Average: 717.77
Monoisotopic: 717.241370179 - Chemical Formula
- C35H35F2N8O5S
- InChI Key
- RSWOJTICKMKTER-QXLBVTBOSA-N
- InChI
- InChI=1S/C35H35F2N8O5S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3/q+1/t22-,23?,35+/m0/s1
- IUPAC Name
- 1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium
- SMILES
- [H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1
Pharmacology
- Indication
Indicated in the treatment of invasive aspergillosis and invasive mucormycosis.
- Associated Conditions
- Pharmacodynamics
- Not Available
- Mechanism of action
Antifungals in the triazole class, such as isavuconazonium, target and inhibit the sterol 14-α-demethylase (Erg11p) which is a key player in the demethylation step of the ergosterol biosynthetic pathway. This inhibition results in a halt in production of ergosterol, a molecule typically found in the membranes of fungi such as Aspergillus, Candida, and Mucorales that plays a role in regulation of membrane integrity, fluidity and permeability. The inhibition of Erg11p also causes the buildup of ergosterol precursors, which are toxic and cause cell death.
- Absorption
When administered intravenously as isavuconazonium, >99% of the prodrug is quickly converted to active isavuconazole (catalyzed by plasma esterases). Oral administration of isavuconazonium shows 98% oral bioavailability, however administration with food results in a 20% decrease in AUC (area under concentration-time curve) as well as decreasing maximum serum concentration (Cmax) by 50% and increasing time to Cmax by 1.5 hours.
- Volume of distribution
450 L
- Protein binding
>99%
- Metabolism
Metabolism is primarily hepatic, with CYP3A4 and CYP3A5 involved in phase I metabolism, followed by modification by uridine diphosphate glucuronosyltransferase (UGT).
- Route of elimination
45% excreted in feces and bile, and 45% excreted in urine as inactive metabolites. Less than 1% of active isavuconazole is excreted unchanged in urine.
- Half life
80 to 130 hours.
- Clearance
- Not Available
- Toxicity
Isavuconazole, the active moiety of isavuconazonium, is classified as Pregnancy Class C and should be avoided in pregnant women. It was also found to be excreted in breast milk in animal studies in rats, therefore it should be avoided in breastfeeding women.
- Affected organisms
- Candida albicans and other yeasts
- Aspergillis, Candida and other fungi
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Isavuconazonium. Approved, Investigational Abiraterone The metabolism of Abiraterone can be decreased when combined with Isavuconazonium. Approved Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Isavuconazonium. Approved, Investigational Acetaminophen The metabolism of Acetaminophen can be decreased when combined with Isavuconazonium. Approved Acetyl sulfisoxazole The metabolism of Isavuconazonium can be decreased when combined with Acetyl sulfisoxazole. Approved, Vet Approved Adinazolam The metabolism of Adinazolam can be decreased when combined with Isavuconazonium. Approved Afatinib The serum concentration of Afatinib can be increased when it is combined with Isavuconazonium. Approved Albendazole The metabolism of Albendazole can be decreased when combined with Isavuconazonium. Approved, Vet Approved Alclometasone The metabolism of Alclometasone can be decreased when combined with Isavuconazonium. Approved Alfentanil The metabolism of Alfentanil can be decreased when combined with Isavuconazonium. Approved, Illicit Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Isavuconazonium. Approved, Investigational Aliskiren The metabolism of Aliskiren can be decreased when combined with Isavuconazonium. Approved, Investigational Allylestrenol The metabolism of Allylestrenol can be decreased when combined with Isavuconazonium. Approved Almotriptan The metabolism of Almotriptan can be decreased when combined with Isavuconazonium. Approved, Investigational Alogliptin The metabolism of Alogliptin can be decreased when combined with Isavuconazonium. Approved Alosetron The metabolism of Alosetron can be decreased when combined with Isavuconazonium. Approved, Withdrawn alpha-Tocopherol acetate The metabolism of alpha-Tocopherol acetate can be decreased when combined with Isavuconazonium. Approved Alprazolam The metabolism of Alprazolam can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Isavuconazonium. Approved, Investigational Ambroxol The metabolism of Ambroxol can be decreased when combined with Isavuconazonium. Approved, Investigational Aminophenazone The metabolism of Aminophenazone can be decreased when combined with Isavuconazonium. Approved, Withdrawn Aminophylline The metabolism of Aminophylline can be decreased when combined with Isavuconazonium. Approved Amiodarone The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Amiodarone. Approved, Investigational Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Isavuconazonium. Approved Amlodipine The metabolism of Amlodipine can be decreased when combined with Isavuconazonium. Approved Amprenavir The metabolism of Amprenavir can be decreased when combined with Isavuconazonium. Approved, Investigational Antipyrine The metabolism of Antipyrine can be decreased when combined with Isavuconazonium. Approved, Investigational Apalutamide The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Apalutamide resulting in a loss in efficacy. Approved, Investigational Apixaban The serum concentration of Apixaban can be increased when it is combined with Isavuconazonium. Approved Apremilast The metabolism of Apremilast can be decreased when combined with Isavuconazonium. Approved, Investigational Aprepitant The serum concentration of Isavuconazonium can be increased when it is combined with Aprepitant. Approved, Investigational Argatroban The metabolism of Argatroban can be decreased when combined with Isavuconazonium. Approved, Investigational Aripiprazole The serum concentration of Aripiprazole can be decreased when it is combined with Isavuconazonium. Approved, Investigational Artemether The metabolism of Artemether can be decreased when combined with Isavuconazonium. Approved Asenapine The metabolism of Asenapine can be decreased when combined with Isavuconazonium. Approved Astemizole The metabolism of Astemizole can be decreased when combined with Isavuconazonium. Approved, Withdrawn Asunaprevir The serum concentration of Asunaprevir can be decreased when it is combined with Isavuconazonium. Approved, Investigational, Withdrawn Atazanavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Atazanavir. Approved, Investigational Atomoxetine The metabolism of Isavuconazonium can be decreased when combined with Atomoxetine. Approved Atorvastatin The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Atorvastatin. Approved Avanafil The serum concentration of Avanafil can be increased when it is combined with Isavuconazonium. Approved Avatrombopag The metabolism of Avatrombopag can be decreased when combined with Isavuconazonium. Approved, Investigational Axitinib The metabolism of Axitinib can be decreased when combined with Isavuconazonium. Approved, Investigational Azelastine The metabolism of Azelastine can be decreased when combined with Isavuconazonium. Approved Azithromycin The metabolism of Azithromycin can be decreased when combined with Isavuconazonium. Approved Banoxantrone The metabolism of Banoxantrone can be decreased when combined with Isavuconazonium. Investigational Baricitinib The metabolism of Baricitinib can be decreased when combined with Isavuconazonium. Approved, Investigational Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Isavuconazonium. Approved Benidipine The metabolism of Benidipine can be decreased when combined with Isavuconazonium. Approved, Investigational Benzphetamine The metabolism of Benzphetamine can be decreased when combined with Isavuconazonium. Approved, Illicit Benzyl alcohol The metabolism of Benzyl alcohol can be decreased when combined with Isavuconazonium. Approved Bexarotene The metabolism of Bexarotene can be decreased when combined with Isavuconazonium. Approved, Investigational Bezafibrate The metabolism of Bezafibrate can be decreased when combined with Isavuconazonium. Approved, Investigational Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Isavuconazonium. Approved Bictegravir The metabolism of Bictegravir can be decreased when combined with Isavuconazonium. Approved, Investigational Bioallethrin The metabolism of Bioallethrin can be decreased when combined with Isavuconazonium. Approved, Experimental Bisoprolol The metabolism of Bisoprolol can be decreased when combined with Isavuconazonium. Approved Blonanserin The metabolism of Blonanserin can be decreased when combined with Isavuconazonium. Approved, Investigational Boceprevir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir. Approved, Withdrawn Bortezomib The metabolism of Isavuconazonium can be decreased when combined with Bortezomib. Approved, Investigational Bosentan The serum concentration of Bosentan can be increased when it is combined with Isavuconazonium. Approved, Investigational Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Isavuconazonium. Approved Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Isavuconazonium. Approved, Investigational Brexpiprazole The serum concentration of Brexpiprazole can be increased when it is combined with Isavuconazonium. Approved, Investigational Brigatinib The metabolism of Brigatinib can be decreased when combined with Isavuconazonium. Approved, Investigational Brinzolamide The metabolism of Brinzolamide can be decreased when combined with Isavuconazonium. Approved Brivaracetam The metabolism of Brivaracetam can be decreased when combined with Isavuconazonium. Approved, Investigational Bromazepam The metabolism of Bromazepam can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Isavuconazonium. Approved, Investigational Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Isavuconazonium. Approved Budesonide The serum concentration of Budesonide can be increased when it is combined with Isavuconazonium. Approved Bupivacaine The metabolism of Bupivacaine can be decreased when combined with Isavuconazonium. Approved, Investigational Buprenorphine The metabolism of Buprenorphine can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational, Vet Approved Bupropion The serum concentration of Bupropion can be decreased when it is combined with Isavuconazonium. Approved Buspirone The metabolism of Buspirone can be decreased when combined with Isavuconazonium. Approved, Investigational Busulfan The metabolism of Busulfan can be decreased when combined with Isavuconazonium. Approved, Investigational Cabazitaxel The metabolism of Cabazitaxel can be decreased when combined with Isavuconazonium. Approved Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Isavuconazonium. Approved Cabozantinib The metabolism of Cabozantinib can be decreased when combined with Isavuconazonium. Approved, Investigational Caffeine The metabolism of Caffeine can be decreased when combined with Isavuconazonium. Approved Calcitriol The metabolism of Calcitriol can be decreased when combined with Isavuconazonium. Approved, Nutraceutical Canagliflozin The metabolism of Canagliflozin can be decreased when combined with Isavuconazonium. Approved Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Isavuconazonium. Approved, Investigational Carbamazepine The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Carbamazepine resulting in a loss in efficacy. Approved, Investigational Carbinoxamine The metabolism of Carbinoxamine can be decreased when combined with Isavuconazonium. Approved Cariprazine The metabolism of Cariprazine can be decreased when combined with Isavuconazonium. Approved, Investigational Carvedilol The metabolism of Carvedilol can be decreased when combined with Isavuconazonium. Approved, Investigational Celecoxib The metabolism of Celecoxib can be decreased when combined with Isavuconazonium. Approved, Investigational Celiprolol The metabolism of Celiprolol can be decreased when combined with Isavuconazonium. Approved, Investigational Cephalexin The metabolism of Cephalexin can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Ceritinib The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ceritinib. Approved Cerivastatin The serum concentration of Cerivastatin can be increased when it is combined with Isavuconazonium. Approved, Withdrawn Cevimeline The metabolism of Cevimeline can be decreased when combined with Isavuconazonium. Approved Chenodeoxycholic acid The metabolism of Chenodeoxycholic acid can be decreased when combined with Isavuconazonium. Approved Chlordiazepoxide The metabolism of Chlordiazepoxide can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational Chloroquine The metabolism of Chloroquine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Chlorphenamine The metabolism of Chlorphenamine can be decreased when combined with Isavuconazonium. Approved Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Isavuconazonium. Approved Cholecalciferol The metabolism of Cholecalciferol can be decreased when combined with Isavuconazonium. Approved, Nutraceutical Ciclesonide The metabolism of Ciclesonide can be decreased when combined with Isavuconazonium. Approved, Investigational Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Isavuconazonium. Approved, Investigational Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Isavuconazonium. Approved Cisapride The metabolism of Cisapride can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Citalopram The metabolism of Citalopram can be decreased when combined with Isavuconazonium. Approved Clarithromycin The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Clarithromycin. Approved Clemastine The metabolism of Isavuconazonium can be decreased when combined with Clemastine. Approved, Investigational Clindamycin The metabolism of Clindamycin can be decreased when combined with Isavuconazonium. Approved, Vet Approved Clobazam The metabolism of Clobazam can be decreased when combined with Isavuconazonium. Approved, Illicit Clofazimine The metabolism of Clofazimine can be decreased when combined with Isavuconazonium. Approved, Investigational Clofibrate The metabolism of Clofibrate can be decreased when combined with Isavuconazonium. Approved, Investigational clomethiazole The metabolism of clomethiazole can be decreased when combined with Isavuconazonium. Investigational Clomipramine The metabolism of Clomipramine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Clonazepam The metabolism of Clonazepam can be decreased when combined with Isavuconazonium. Approved, Illicit Clonidine The metabolism of Clonidine can be decreased when combined with Isavuconazonium. Approved Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Isavuconazonium. Approved Clorazepate The metabolism of Clorazepate can be decreased when combined with Isavuconazonium. Approved, Illicit Clotiazepam The metabolism of Clotiazepam can be decreased when combined with Isavuconazonium. Approved, Illicit Clotrimazole The metabolism of Isavuconazonium can be decreased when combined with Clotrimazole. Approved, Vet Approved Clozapine The metabolism of Clozapine can be decreased when combined with Isavuconazonium. Approved Cobicistat The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Cobicistat. Approved Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Isavuconazonium. Approved, Investigational Cocaine The metabolism of Cocaine can be decreased when combined with Isavuconazonium. Approved, Illicit Codeine The metabolism of Codeine can be decreased when combined with Isavuconazonium. Approved, Illicit Colchicine The serum concentration of Colchicine can be increased when it is combined with Isavuconazonium. Approved Conivaptan The serum concentration of Conivaptan can be increased when it is combined with Isavuconazonium. Approved, Investigational Conjugated estrogens The metabolism of Conjugated estrogens can be decreased when combined with Isavuconazonium. Approved Copanlisib The metabolism of Copanlisib can be decreased when combined with Isavuconazonium. Approved, Investigational Cortisone acetate The metabolism of Cortisone acetate can be decreased when combined with Isavuconazonium. Approved, Investigational Crizotinib The metabolism of Isavuconazonium can be decreased when combined with Crizotinib. Approved Curcumin The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Curcumin. Approved, Investigational Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Isavuconazonium. Approved Cyclophosphamide The metabolism of Cyclophosphamide can be decreased when combined with Isavuconazonium. Approved, Investigational Cyclosporine The metabolism of Isavuconazonium can be decreased when combined with Cyclosporine. Approved, Investigational, Vet Approved Cytarabine The metabolism of Cytarabine can be decreased when combined with Isavuconazonium. Approved, Investigational Dabigatran etexilate The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Isavuconazonium. Approved Dabrafenib The serum concentration of Isavuconazonium can be decreased when it is combined with Dabrafenib. Approved, Investigational Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Isavuconazonium. Approved, Investigational Dantrolene The metabolism of Dantrolene can be decreased when combined with Isavuconazonium. Approved, Investigational Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Isavuconazonium. Approved Dapoxetine The serum concentration of Dapoxetine can be increased when it is combined with Isavuconazonium. Investigational Dapsone The metabolism of Dapsone can be decreased when combined with Isavuconazonium. Approved, Investigational Darifenacin The metabolism of Darifenacin can be decreased when combined with Isavuconazonium. Approved, Investigational Darunavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir. Approved Dasabuvir The metabolism of Dasabuvir can be decreased when combined with Isavuconazonium. Approved Dasatinib The serum concentration of Isavuconazonium can be increased when it is combined with Dasatinib. Approved, Investigational Daunorubicin The metabolism of Daunorubicin can be decreased when combined with Isavuconazonium. Approved Deferasirox The serum concentration of Isavuconazonium can be decreased when it is combined with Deferasirox. Approved, Investigational Deflazacort The metabolism of Deflazacort can be decreased when combined with Isavuconazonium. Approved, Investigational Delamanid The metabolism of Delamanid can be decreased when combined with Isavuconazonium. Approved, Investigational Delavirdine The metabolism of Isavuconazonium can be decreased when combined with Delavirdine. Approved Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Isavuconazonium. Approved, Investigational Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Isavuconazonium. Approved, Investigational Dexamethasone The metabolism of Dexamethasone can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Dexchlorpheniramine maleate The metabolism of Dexchlorpheniramine maleate can be decreased when combined with Isavuconazonium. Approved Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Isavuconazonium. Approved, Investigational Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Isavuconazonium. Approved Dextropropoxyphene The metabolism of Dextropropoxyphene can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational, Withdrawn Diazepam The metabolism of Diazepam can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational, Vet Approved Diclofenac The metabolism of Diclofenac can be decreased when combined with Isavuconazonium. Approved, Vet Approved Dienogest The metabolism of Dienogest can be decreased when combined with Isavuconazonium. Approved Digitoxin The metabolism of Digitoxin can be decreased when combined with Isavuconazonium. Approved, Investigational Digoxin The serum concentration of Digoxin can be increased when it is combined with Isavuconazonium. Approved Dihydro-alpha-ergocryptine The metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Isavuconazonium. Approved Dihydrocodeine The metabolism of Dihydrocodeine can be decreased when combined with Isavuconazonium. Approved, Illicit Dihydroergocornine The risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Isavuconazonium. Approved Dihydroergocristine The risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Isavuconazonium. Approved, Experimental Dihydroergocryptine The risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Isavuconazonium. Experimental Dihydroergotamine The risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Isavuconazonium. Approved, Investigational Diltiazem The metabolism of Isavuconazonium can be decreased when combined with Diltiazem. Approved, Investigational Disopyramide The metabolism of Disopyramide can be decreased when combined with Isavuconazonium. Approved Disulfiram The metabolism of Disulfiram can be decreased when combined with Isavuconazonium. Approved Docetaxel The metabolism of Docetaxel can be decreased when combined with Isavuconazonium. Approved, Investigational Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Isavuconazonium. Approved, Investigational Dolasetron The metabolism of Dolasetron can be decreased when combined with Isavuconazonium. Approved, Investigational Domperidone The serum concentration of Domperidone can be increased when it is combined with Isavuconazonium. Approved, Investigational, Vet Approved Donepezil The metabolism of Donepezil can be decreased when combined with Isavuconazonium. Approved Dorzolamide The metabolism of Dorzolamide can be decreased when combined with Isavuconazonium. Approved Doxepin The metabolism of Doxepin can be decreased when combined with Isavuconazonium. Approved, Investigational Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Isavuconazonium. Approved, Investigational Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Isavuconazonium. Approved, Investigational Doxycycline The metabolism of Isavuconazonium can be decreased when combined with Doxycycline. Approved, Investigational, Vet Approved Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium. Approved, Illicit Dronedarone The metabolism of Isavuconazonium can be decreased when combined with Dronedarone. Approved Dutasteride The metabolism of Dutasteride can be decreased when combined with Isavuconazonium. Approved, Investigational Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Isavuconazonium. Approved Efavirenz The metabolism of Efavirenz can be decreased when combined with Isavuconazonium. Approved, Investigational Elbasvir The metabolism of Elbasvir can be decreased when combined with Isavuconazonium. Approved Eletriptan The serum concentration of Eletriptan can be increased when it is combined with Isavuconazonium. Approved, Investigational Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Isavuconazonium. Approved Elvitegravir The metabolism of Elvitegravir can be decreased when combined with Isavuconazonium. Approved Enalapril The metabolism of Enalapril can be decreased when combined with Isavuconazonium. Approved, Vet Approved Enasidenib The metabolism of Enasidenib can be decreased when combined with Isavuconazonium. Approved, Investigational Enzalutamide The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Enzalutamide resulting in a loss in efficacy. Approved Epinastine The metabolism of Epinastine can be decreased when combined with Isavuconazonium. Approved, Investigational Eplerenone The serum concentration of Eplerenone can be increased when it is combined with Isavuconazonium. Approved Ergocalciferol The metabolism of Ergocalciferol can be decreased when combined with Isavuconazonium. Approved, Nutraceutical Ergoloid mesylate The metabolism of Ergoloid mesylate can be decreased when combined with Isavuconazonium. Approved Ergonovine The risk or severity of adverse effects can be increased when Ergonovine is combined with Isavuconazonium. Approved Ergotamine The risk or severity of adverse effects can be increased when Ergotamine is combined with Isavuconazonium. Approved Erlotinib The metabolism of Erlotinib can be decreased when combined with Isavuconazonium. Approved, Investigational Erythromycin The metabolism of Isavuconazonium can be decreased when combined with Erythromycin. Approved, Investigational, Vet Approved Escitalopram The metabolism of Escitalopram can be decreased when combined with Isavuconazonium. Approved, Investigational Esomeprazole The metabolism of Esomeprazole can be decreased when combined with Isavuconazonium. Approved, Investigational Estazolam The metabolism of Estazolam can be decreased when combined with Isavuconazonium. Approved, Illicit Estradiol The metabolism of Estradiol can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estradiol acetate The metabolism of Estradiol acetate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estradiol benzoate The metabolism of Estradiol benzoate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estradiol cypionate The metabolism of Estradiol cypionate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estradiol dienanthate The metabolism of Estradiol dienanthate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estradiol valerate The metabolism of Estradiol valerate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Estramustine The metabolism of Estramustine can be decreased when combined with Isavuconazonium. Approved, Investigational Estrogens, esterified The metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium. Approved Estrone The metabolism of Estrone can be decreased when combined with Isavuconazonium. Approved Estrone sulfate The metabolism of Estrone sulfate can be decreased when combined with Isavuconazonium. Approved Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Isavuconazonium. Approved, Investigational Ethanol The metabolism of Ethanol can be decreased when combined with Isavuconazonium. Approved Ethinyl Estradiol The metabolism of Ethinyl Estradiol can be decreased when combined with Isavuconazonium. Approved Ethosuximide The metabolism of Ethosuximide can be decreased when combined with Isavuconazonium. Approved Ethylmorphine The metabolism of Ethylmorphine can be decreased when combined with Isavuconazonium. Approved, Illicit Etizolam The metabolism of Etizolam can be decreased when combined with Isavuconazonium. Approved Etonogestrel The metabolism of Etonogestrel can be decreased when combined with Isavuconazonium. Approved, Investigational Etoposide The metabolism of Etoposide can be decreased when combined with Isavuconazonium. Approved Etoricoxib The metabolism of Etoricoxib can be decreased when combined with Isavuconazonium. Approved, Investigational Etravirine The metabolism of Etravirine can be decreased when combined with Isavuconazonium. Approved Everolimus The serum concentration of Everolimus can be increased when it is combined with Isavuconazonium. Approved Exemestane The metabolism of Exemestane can be decreased when combined with Isavuconazonium. Approved, Investigational Famciclovir The metabolism of Famciclovir can be decreased when combined with Isavuconazonium. Approved, Investigational Felbamate The metabolism of Felbamate can be decreased when combined with Isavuconazonium. Approved Felodipine The metabolism of Felodipine can be decreased when combined with Isavuconazonium. Approved, Investigational Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Isavuconazonium. Approved Fentanyl The serum concentration of Fentanyl can be increased when it is combined with Isavuconazonium. Approved, Illicit, Investigational, Vet Approved Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Isavuconazonium. Approved Finasteride The metabolism of Finasteride can be decreased when combined with Isavuconazonium. Approved Fingolimod The metabolism of Fingolimod can be decreased when combined with Isavuconazonium. Approved, Investigational Flibanserin The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Flibanserin. Approved, Investigational Fluconazole The metabolism of Isavuconazonium can be decreased when combined with Fluconazole. Approved, Investigational Flunisolide The metabolism of Flunisolide can be decreased when combined with Isavuconazonium. Approved, Investigational Flunitrazepam The metabolism of Flunitrazepam can be decreased when combined with Isavuconazonium. Approved, Illicit Fluorometholone The metabolism of Fluorometholone can be decreased when combined with Isavuconazonium. Approved, Investigational Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Isavuconazonium. Approved, Vet Approved Flurazepam The metabolism of Flurazepam can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational Flutamide The metabolism of Flutamide can be decreased when combined with Isavuconazonium. Approved, Investigational Fluticasone furoate The metabolism of Fluticasone furoate can be decreased when combined with Isavuconazonium. Approved Fluticasone propionate The metabolism of Fluticasone propionate can be decreased when combined with Isavuconazonium. Approved Fluvastatin The serum concentration of Fluvastatin can be increased when it is combined with Isavuconazonium. Approved Fluvoxamine The metabolism of Isavuconazonium can be decreased when combined with Fluvoxamine. Approved, Investigational Fosamprenavir The metabolism of Isavuconazonium can be decreased when combined with Fosamprenavir. Approved Fosaprepitant The serum concentration of Isavuconazonium can be increased when it is combined with Fosaprepitant. Approved Fosnetupitant The metabolism of Fosnetupitant can be decreased when combined with Isavuconazonium. Approved Fosphenytoin The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Fosphenytoin resulting in a loss in efficacy. Approved, Investigational Fostamatinib The metabolism of Fostamatinib can be decreased when combined with Isavuconazonium. Approved, Investigational Fulvestrant The metabolism of Fulvestrant can be decreased when combined with Isavuconazonium. Approved, Investigational Fusidic Acid The serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid. Approved, Investigational Galantamine The metabolism of Galantamine can be decreased when combined with Isavuconazonium. Approved Gefitinib The metabolism of Gefitinib can be decreased when combined with Isavuconazonium. Approved, Investigational Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Isavuconazonium. Approved Glipizide The metabolism of Glipizide can be decreased when combined with Isavuconazonium. Approved, Investigational Glyburide The metabolism of Glyburide can be decreased when combined with Isavuconazonium. Approved Granisetron The metabolism of Granisetron can be decreased when combined with Isavuconazonium. Approved, Investigational Grazoprevir The metabolism of Grazoprevir can be decreased when combined with Isavuconazonium. Approved Grepafloxacin The metabolism of Grepafloxacin can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Guanfacine The metabolism of Guanfacine can be decreased when combined with Isavuconazonium. Approved, Investigational Halofantrine The serum concentration of Halofantrine can be increased when it is combined with Isavuconazonium. Approved Haloperidol The metabolism of Haloperidol can be decreased when combined with Isavuconazonium. Approved Halothane The metabolism of Halothane can be decreased when combined with Isavuconazonium. Approved, Vet Approved Hexobarbital The metabolism of Hexobarbital can be decreased when combined with Isavuconazonium. Approved Histamine The metabolism of Histamine can be decreased when combined with Isavuconazonium. Approved, Investigational Hydrocodone The serum concentration of Hydrocodone can be increased when it is combined with Isavuconazonium. Approved, Illicit Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Hydromorphone The metabolism of Hydromorphone can be decreased when combined with Isavuconazonium. Approved, Illicit Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Isavuconazonium. Approved, Investigational Ibrutinib The serum concentration of Ibrutinib can be increased when it is combined with Isavuconazonium. Approved Icotinib The metabolism of Icotinib can be decreased when combined with Isavuconazonium. Approved, Investigational Idelalisib The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Idelalisib. Approved Ifosfamide The serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Isavuconazonium resulting in a loss in efficacy. Approved Iloperidone The metabolism of Iloperidone can be decreased when combined with Isavuconazonium. Approved Imatinib The serum concentration of Imatinib can be increased when it is combined with Isavuconazonium. Approved Imidafenacin The metabolism of Imidafenacin can be decreased when combined with Isavuconazonium. Approved, Investigational Imipramine The metabolism of Imipramine can be decreased when combined with Isavuconazonium. Approved Imiquimod The metabolism of Imiquimod can be decreased when combined with Isavuconazonium. Approved, Investigational Indacaterol The metabolism of Indacaterol can be decreased when combined with Isavuconazonium. Approved Indapamide The metabolism of Indapamide can be decreased when combined with Isavuconazonium. Approved Indinavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Indinavir. Approved Ipecac The metabolism of Ipecac can be decreased when combined with Isavuconazonium. Approved, Withdrawn Ipratropium The metabolism of Ipratropium bromide can be decreased when combined with Isavuconazonium. Approved Irinotecan The metabolism of Irinotecan can be decreased when combined with Isavuconazonium. Approved, Investigational Isavuconazole The serum concentration of Isavuconazonium can be increased when it is combined with Isavuconazole. Approved, Investigational Isosorbide Dinitrate The metabolism of Isosorbide Dinitrate can be decreased when combined with Isavuconazonium. Approved, Investigational Isosorbide Mononitrate The metabolism of Isosorbide Mononitrate can be decreased when combined with Isavuconazonium. Approved Isradipine The metabolism of Isavuconazonium can be decreased when combined with Isradipine. Approved, Investigational Itraconazole The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Itraconazole. Approved, Investigational Ivabradine The serum concentration of Ivabradine can be increased when it is combined with Isavuconazonium. Approved Ivacaftor The serum concentration of Ivacaftor can be increased when it is combined with Isavuconazonium. Approved Ivermectin The metabolism of Ivermectin can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Ixabepilone The metabolism of Ixabepilone can be decreased when combined with Isavuconazonium. Approved, Investigational Ixazomib The metabolism of Ixazomib can be decreased when combined with Isavuconazonium. Approved, Investigational Ketamine The metabolism of Ketamine can be decreased when combined with Isavuconazonium. Approved, Vet Approved Ketazolam The metabolism of Ketazolam can be decreased when combined with Isavuconazonium. Approved Ketobemidone The metabolism of Ketobemidone can be decreased when combined with Isavuconazonium. Approved, Investigational Ketoconazole The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ketoconazole. Approved, Investigational Lacidipine The metabolism of Lacidipine can be decreased when combined with Isavuconazonium. Approved, Investigational Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Isavuconazonium. Approved, Investigational Lapatinib The metabolism of Lapatinib can be decreased when combined with Isavuconazonium. Approved, Investigational Laquinimod The metabolism of Laquinimod can be decreased when combined with Isavuconazonium. Investigational Ledipasvir The serum concentration of Ledipasvir can be increased when it is combined with Isavuconazonium. Approved Lenvatinib The metabolism of Lenvatinib can be decreased when combined with Isavuconazonium. Approved, Investigational Lercanidipine The metabolism of Lercanidipine can be decreased when combined with Isavuconazonium. Approved, Investigational Letrozole The metabolism of Letrozole can be decreased when combined with Isavuconazonium. Approved, Investigational Levobupivacaine The metabolism of Levobupivacaine can be decreased when combined with Isavuconazonium. Approved, Investigational Levocetirizine The metabolism of Levocetirizine can be decreased when combined with Isavuconazonium. Approved Levomethadyl Acetate The metabolism of Levomethadyl Acetate can be decreased when combined with Isavuconazonium. Approved, Investigational Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Isavuconazonium. Approved, Investigational Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Isavuconazonium. Approved, Investigational Levothyroxine The metabolism of Levothyroxine can be decreased when combined with Isavuconazonium. Approved Lidocaine The metabolism of Lidocaine can be decreased when combined with Isavuconazonium. Approved, Vet Approved Lisuride The risk or severity of adverse effects can be increased when Lisuride is combined with Isavuconazonium. Approved, Investigational Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Isavuconazonium. Approved, Investigational Loperamide The metabolism of Loperamide can be decreased when combined with Isavuconazonium. Approved Lopinavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Lopinavir. Approved Loratadine The metabolism of Loratadine can be decreased when combined with Isavuconazonium. Approved, Investigational Lorcaserin The metabolism of Lorcaserin can be decreased when combined with Isavuconazonium. Approved Lorpiprazole The serum concentration of Isavuconazonium can be increased when it is combined with Lorpiprazole. Approved Losartan The metabolism of Losartan can be decreased when combined with Isavuconazonium. Approved Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Isavuconazonium. Approved, Investigational Luliconazole The serum concentration of Isavuconazonium can be increased when it is combined with Luliconazole. Approved Lumacaftor The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Lumacaftor resulting in a loss in efficacy. Approved Lumefantrine The metabolism of Lumefantrine can be decreased when combined with Isavuconazonium. Approved Lurasidone The serum concentration of Lurasidone can be increased when it is combined with Isavuconazonium. Approved, Investigational Lysergic Acid Diethylamide The risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Isavuconazonium. Illicit, Investigational, Withdrawn Macimorelin The metabolism of Macimorelin can be decreased when combined with Isavuconazonium. Approved, Investigational Macitentan The metabolism of Macitentan can be decreased when combined with Isavuconazonium. Approved Maraviroc The metabolism of Maraviroc can be decreased when combined with Isavuconazonium. Approved, Investigational Mebendazole The metabolism of Mebendazole can be decreased when combined with Isavuconazonium. Approved, Vet Approved Medical Cannabis The metabolism of Medical Cannabis can be decreased when combined with Isavuconazonium. Experimental, Investigational Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be decreased when combined with Isavuconazonium. Approved, Investigational Mefloquine The metabolism of Mefloquine can be decreased when combined with Isavuconazonium. Approved, Investigational Meloxicam The metabolism of Meloxicam can be decreased when combined with Isavuconazonium. Approved, Vet Approved Metergoline The risk or severity of adverse effects can be increased when Metergoline is combined with Isavuconazonium. Experimental Methadone The metabolism of Methadone can be decreased when combined with Isavuconazonium. Approved Methaqualone The metabolism of Methaqualone can be decreased when combined with Isavuconazonium. Illicit, Withdrawn Methoxsalen The metabolism of Methoxsalen can be decreased when combined with Isavuconazonium. Approved Methoxyflurane The metabolism of Methoxyflurane can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Methylergometrine The risk or severity of adverse effects can be increased when Methylergometrine is combined with Isavuconazonium. Approved Methylprednisolone The metabolism of Methylprednisolone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Methyltestosterone The metabolism of Methyltestosterone can be decreased when combined with Isavuconazonium. Approved Methysergide The risk or severity of adverse effects can be increased when Methysergide is combined with Isavuconazonium. Approved Metronidazole The metabolism of Metronidazole can be decreased when combined with Isavuconazonium. Approved Mevastatin The serum concentration of Mevastatin can be increased when it is combined with Isavuconazonium. Experimental Mexiletine The metabolism of Mexiletine can be decreased when combined with Isavuconazonium. Approved, Investigational Mianserin The metabolism of Mianserin can be decreased when combined with Isavuconazonium. Approved, Investigational Mibefradil The metabolism of Mibefradil can be decreased when combined with Isavuconazonium. Investigational, Withdrawn Miconazole The metabolism of Miconazole can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Midazolam The metabolism of Midazolam can be decreased when combined with Isavuconazonium. Approved, Illicit Midecamycin The metabolism of Midecamycin can be decreased when combined with Isavuconazonium. Approved Midostaurin The metabolism of Midostaurin can be decreased when combined with Isavuconazonium. Approved, Investigational Mifepristone The serum concentration of Isavuconazonium can be increased when it is combined with Mifepristone. Approved, Investigational Mirabegron The metabolism of Mirabegron can be decreased when combined with Isavuconazonium. Approved Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Isavuconazonium. Approved Mitotane The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Mitotane resulting in a loss in efficacy. Approved Modafinil The metabolism of Modafinil can be decreased when combined with Isavuconazonium. Approved, Investigational Montelukast The metabolism of Montelukast can be decreased when combined with Isavuconazonium. Approved Morphine The metabolism of Morphine can be decreased when combined with Isavuconazonium. Approved, Investigational Mycophenolate mofetil The metabolism of Mycophenolate mofetil can be decreased when combined with Isavuconazonium. Approved, Investigational Mycophenolic acid The serum concentration of Mycophenolic acid can be increased when it is combined with Isavuconazonium. Approved Nabiximols The metabolism of Nabiximols can be decreased when combined with Isavuconazonium. Approved, Investigational Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Isavuconazonium. Approved Naloxone The metabolism of Naloxone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Nateglinide The metabolism of Nateglinide can be decreased when combined with Isavuconazonium. Approved, Investigational Nefazodone The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nefazodone. Approved, Withdrawn Nelfinavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nelfinavir. Approved Neratinib The metabolism of Neratinib can be decreased when combined with Isavuconazonium. Approved, Investigational Netupitant The serum concentration of Isavuconazonium can be increased when it is combined with Netupitant. Approved, Investigational Nevirapine The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Nevirapine resulting in a loss in efficacy. Approved Nicardipine The metabolism of Nicardipine can be decreased when combined with Isavuconazonium. Approved, Investigational Nicergoline The risk or severity of adverse effects can be increased when Nicergoline is combined with Isavuconazonium. Approved, Investigational Nicotine The metabolism of Nicotine can be decreased when combined with Isavuconazonium. Approved Nifedipine The metabolism of Nifedipine can be decreased when combined with Isavuconazonium. Approved Nilotinib The metabolism of Isavuconazonium can be decreased when combined with Nilotinib. Approved, Investigational Nilvadipine The metabolism of Nilvadipine can be decreased when combined with Isavuconazonium. Approved, Investigational Nimodipine The serum concentration of Nimodipine can be increased when it is combined with Isavuconazonium. Approved, Investigational Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Isavuconazonium. Approved Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Isavuconazonium. Approved Nitrazepam The metabolism of Nitrazepam can be decreased when combined with Isavuconazonium. Approved Nitrendipine The metabolism of Nitrendipine can be decreased when combined with Isavuconazonium. Approved, Investigational Norethisterone The metabolism of Norethisterone can be decreased when combined with Isavuconazonium. Approved Norgestrel The metabolism of Norgestrel can be decreased when combined with Isavuconazonium. Approved Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Isavuconazonium. Approved Odanacatib The metabolism of Odanacatib can be decreased when combined with Isavuconazonium. Investigational Olaparib The serum concentration of Olaparib can be increased when it is combined with Isavuconazonium. Approved Olopatadine The metabolism of Olopatadine can be decreased when combined with Isavuconazonium. Approved Omeprazole The metabolism of Omeprazole can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Ondansetron The metabolism of Ondansetron can be decreased when combined with Isavuconazonium. Approved Opium The metabolism of Opium can be decreased when combined with Isavuconazonium. Approved, Illicit Orphenadrine The metabolism of Orphenadrine can be decreased when combined with Isavuconazonium. Approved Osimertinib The serum concentration of Isavuconazonium can be increased when it is combined with Osimertinib. Approved Ospemifene The metabolism of Ospemifene can be decreased when combined with Isavuconazonium. Approved, Investigational Oxazepam The metabolism of Oxazepam can be decreased when combined with Isavuconazonium. Approved Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Isavuconazonium. Approved, Investigational Oxycodone The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Oxycodone. Approved, Illicit, Investigational Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Paclitaxel The metabolism of Paclitaxel can be decreased when combined with Isavuconazonium. Approved, Vet Approved Palbociclib The serum concentration of Isavuconazonium can be increased when it is combined with Palbociclib. Approved, Investigational Palonosetron The metabolism of Palonosetron can be decreased when combined with Isavuconazonium. Approved, Investigational Panobinostat The metabolism of Panobinostat can be decreased when combined with Isavuconazonium. Approved, Investigational Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Isavuconazonium. Approved Paramethadione The metabolism of Paramethadione can be decreased when combined with Isavuconazonium. Approved Paramethasone The metabolism of Paramethasone can be decreased when combined with Isavuconazonium. Approved Parecoxib The metabolism of Parecoxib can be decreased when combined with Isavuconazonium. Approved Paricalcitol The metabolism of Paricalcitol can be decreased when combined with Isavuconazonium. Approved, Investigational Paritaprevir The metabolism of Paritaprevir can be decreased when combined with Isavuconazonium. Approved, Investigational Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Isavuconazonium. Approved Pentamidine The metabolism of Pentamidine can be decreased when combined with Isavuconazonium. Approved, Investigational Pentobarbital The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Pentobarbital resulting in a loss in efficacy. Approved, Investigational, Vet Approved Perampanel The metabolism of Perampanel can be decreased when combined with Isavuconazonium. Approved Pergolide The risk or severity of adverse effects can be increased when Pergolide is combined with Isavuconazonium. Approved, Investigational, Vet Approved, Withdrawn Perhexiline The metabolism of Perhexiline can be decreased when combined with Isavuconazonium. Approved, Investigational Permethrin The metabolism of Permethrin can be decreased when combined with Isavuconazonium. Approved, Investigational Perospirone The metabolism of Perospirone can be decreased when combined with Isavuconazonium. Approved Perphenazine The metabolism of Perphenazine can be decreased when combined with Isavuconazonium. Approved Pethidine The metabolism of Pethidine can be decreased when combined with Isavuconazonium. Approved Phenacetin The metabolism of Phenacetin can be decreased when combined with Isavuconazonium. Withdrawn Phenobarbital The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenobarbital resulting in a loss in efficacy. Approved, Investigational Phenoxybenzamine The metabolism of Phenoxybenzamine can be decreased when combined with Isavuconazonium. Approved Phenprocoumon The metabolism of Phenprocoumon can be decreased when combined with Isavuconazonium. Approved, Investigational Phenytoin The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Phenytoin resulting in a loss in efficacy. Approved, Vet Approved Pilocarpine The metabolism of Pilocarpine can be decreased when combined with Isavuconazonium. Approved, Investigational Pimecrolimus The metabolism of Pimecrolimus can be decreased when combined with Isavuconazonium. Approved, Investigational Pimozide The serum concentration of Pimozide can be increased when it is combined with Isavuconazonium. Approved Pinacidil The metabolism of Pinacidil can be decreased when combined with Isavuconazonium. Approved Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Isavuconazonium. Approved, Investigational Piperaquine The metabolism of Piperaquine can be decreased when combined with Isavuconazonium. Approved, Investigational Pipotiazine The metabolism of Pipotiazine can be decreased when combined with Isavuconazonium. Approved, Investigational Pitavastatin The serum concentration of Pitavastatin can be increased when it is combined with Isavuconazonium. Approved Pitolisant The serum concentration of Isavuconazonium can be decreased when it is combined with Pitolisant. Approved, Investigational Podofilox The metabolism of Podofilox can be decreased when combined with Isavuconazonium. Approved Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Isavuconazonium. Approved Ponatinib The metabolism of Ponatinib can be decreased when combined with Isavuconazonium. Approved, Investigational Posaconazole The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Posaconazole. Approved, Investigational, Vet Approved Prasterone The metabolism of Prasterone can be decreased when combined with Isavuconazonium. Approved, Investigational, Nutraceutical Prasugrel The metabolism of Prasugrel can be decreased when combined with Isavuconazonium. Approved Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Isavuconazonium. Approved Prazepam The metabolism of Prazepam can be decreased when combined with Isavuconazonium. Approved, Illicit Praziquantel The metabolism of Praziquantel can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Prednisolone The metabolism of Prednisolone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Prednisone The metabolism of Prednisone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Primaquine The metabolism of Primaquine can be decreased when combined with Isavuconazonium. Approved Primidone The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Primidone resulting in a loss in efficacy. Approved, Vet Approved Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Isavuconazonium. Approved, Vet Approved Progesterone The metabolism of Progesterone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Proguanil The metabolism of Proguanil can be decreased when combined with Isavuconazonium. Approved Promazine The metabolism of Promazine can be decreased when combined with Isavuconazonium. Approved, Vet Approved Propafenone The serum concentration of Propafenone can be increased when it is combined with Isavuconazonium. Approved Propiverine The metabolism of Propiverine can be decreased when combined with Isavuconazonium. Approved, Investigational Propofol The metabolism of Propofol can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Propranolol The metabolism of Propranolol can be decreased when combined with Isavuconazonium. Approved, Investigational Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Isavuconazonium. Approved Pyrazinamide The metabolism of Pyrazinamide can be decreased when combined with Isavuconazonium. Approved, Investigational Quazepam The metabolism of Quazepam can be decreased when combined with Isavuconazonium. Approved, Illicit Quetiapine The metabolism of Quetiapine can be decreased when combined with Isavuconazonium. Approved Quinacrine The metabolism of Quinacrine can be decreased when combined with Isavuconazonium. Approved, Investigational Quinidine The metabolism of Quinidine can be decreased when combined with Isavuconazonium. Approved, Investigational Quinine The metabolism of Quinine can be decreased when combined with Isavuconazonium. Approved Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Isavuconazonium. Approved, Investigational Raloxifene The metabolism of Raloxifene can be decreased when combined with Isavuconazonium. Approved, Investigational Ramelteon The metabolism of Ramelteon can be decreased when combined with Isavuconazonium. Approved, Investigational Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Isavuconazonium. Approved, Investigational Reboxetine The metabolism of Reboxetine can be decreased when combined with Isavuconazonium. Approved, Investigational Regorafenib The metabolism of Regorafenib can be decreased when combined with Isavuconazonium. Approved Repaglinide The metabolism of Repaglinide can be decreased when combined with Isavuconazonium. Approved, Investigational Retapamulin The metabolism of Retapamulin can be decreased when combined with Isavuconazonium. Approved Rifabutin The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy. Approved, Investigational Rifampicin The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy. Approved Rifapentine The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifapentine resulting in a loss in efficacy. Approved, Investigational Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Isavuconazonium. Approved, Investigational Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Isavuconazonium. Approved Rimonabant The metabolism of Rimonabant can be decreased when combined with Isavuconazonium. Approved, Investigational Riociguat The metabolism of Riociguat can be decreased when combined with Isavuconazonium. Approved Risperidone The metabolism of Risperidone can be decreased when combined with Isavuconazonium. Approved, Investigational Ritonavir The metabolism of Ritonavir can be decreased when combined with Isavuconazonium. Approved, Investigational Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Isavuconazonium. Approved Rofecoxib The metabolism of Rofecoxib can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Rolapitant The metabolism of Rolapitant can be decreased when combined with Isavuconazonium. Approved, Investigational Romidepsin The metabolism of Romidepsin can be decreased when combined with Isavuconazonium. Approved, Investigational Ropinirole The metabolism of Ropinirole can be decreased when combined with Isavuconazonium. Approved, Investigational Ropivacaine The metabolism of Ropivacaine can be decreased when combined with Isavuconazonium. Approved Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Isavuconazonium. Approved Rotigotine The metabolism of Rotigotine can be decreased when combined with Isavuconazonium. Approved Roxithromycin The metabolism of Roxithromycin can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Rucaparib The metabolism of Rucaparib can be decreased when combined with Isavuconazonium. Approved, Investigational Rupatadine The metabolism of Rupatadine can be decreased when combined with Isavuconazonium. Approved Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Isavuconazonium. Approved Safinamide The metabolism of Safinamide can be decreased when combined with Isavuconazonium. Approved, Investigational Salmeterol The serum concentration of Salmeterol can be increased when it is combined with Isavuconazonium. Approved Saquinavir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Saquinavir. Approved, Investigational Sarilumab The therapeutic efficacy of Isavuconazonium can be decreased when used in combination with Sarilumab. Approved, Investigational Saxagliptin The serum concentration of Saxagliptin can be increased when it is combined with Isavuconazonium. Approved Selegiline The metabolism of Selegiline can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Selexipag The metabolism of Selexipag can be decreased when combined with Isavuconazonium. Approved Seratrodast The metabolism of Seratrodast can be decreased when combined with Isavuconazonium. Approved Sertindole The metabolism of Sertindole can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Sertraline The metabolism of Sertraline can be decreased when combined with Isavuconazonium. Approved Sevoflurane The metabolism of Sevoflurane can be decreased when combined with Isavuconazonium. Approved, Vet Approved Sibutramine The metabolism of Sibutramine can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational, Withdrawn Sildenafil The metabolism of Isavuconazonium can be decreased when combined with Sildenafil. Approved, Investigational Silodosin The serum concentration of Silodosin can be increased when it is combined with Isavuconazonium. Approved Siltuximab The serum concentration of Isavuconazonium can be decreased when it is combined with Siltuximab. Approved, Investigational Simeprevir The serum concentration of Isavuconazonium can be increased when it is combined with Simeprevir. Approved Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Isavuconazonium. Approved Sirolimus The metabolism of Sirolimus can be decreased when combined with Isavuconazonium. Approved, Investigational Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Isavuconazonium. Approved, Investigational Solifenacin The metabolism of Solifenacin can be decreased when combined with Isavuconazonium. Approved Sonidegib The serum concentration of Sonidegib can be increased when it is combined with Isavuconazonium. Approved, Investigational Sorafenib The metabolism of Sorafenib can be decreased when combined with Isavuconazonium. Approved, Investigational Spiramycin The metabolism of Spiramycin can be decreased when combined with Isavuconazonium. Approved St. John's Wort The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with St. John's Wort resulting in a loss in efficacy. Approved, Investigational, Nutraceutical Stiripentol The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Stiripentol. Approved Sufentanil The metabolism of Sufentanil can be decreased when combined with Isavuconazonium. Approved, Investigational Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Sulfamethoxazole The metabolism of Sulfamethoxazole can be decreased when combined with Isavuconazonium. Approved Sulfinpyrazone The metabolism of Sulfinpyrazone can be decreased when combined with Isavuconazonium. Approved Sulfisoxazole The metabolism of Isavuconazonium can be decreased when combined with Sulfisoxazole. Approved, Vet Approved Sunitinib The metabolism of Sunitinib can be decreased when combined with Isavuconazonium. Approved, Investigational Suvorexant The serum concentration of Suvorexant can be increased when it is combined with Isavuconazonium. Approved, Investigational Synthetic Conjugated Estrogens, A The metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Isavuconazonium. Approved Synthetic Conjugated Estrogens, B The metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Isavuconazonium. Approved Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Isavuconazonium. Approved, Investigational Tadalafil The metabolism of Tadalafil can be decreased when combined with Isavuconazonium. Approved, Investigational Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Isavuconazonium. Approved Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Isavuconazonium. Approved, Investigational Tasosartan The metabolism of Tasosartan can be decreased when combined with Isavuconazonium. Approved Taurochenodeoxycholic acid The metabolism of Taurochenodeoxycholic acid can be decreased when combined with Isavuconazonium. Experimental Telaprevir The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir. Approved, Withdrawn Telithromycin The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin. Approved Temazepam The metabolism of Temazepam can be decreased when combined with Isavuconazonium. Approved, Investigational Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Isavuconazonium. Approved Teniposide The metabolism of Teniposide can be decreased when combined with Isavuconazonium. Approved Terbinafine The metabolism of Terbinafine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Terfenadine The metabolism of Terfenadine can be decreased when combined with Isavuconazonium. Approved, Withdrawn Terguride The risk or severity of adverse effects can be increased when Terguride is combined with Isavuconazonium. Experimental Tesmilifene The metabolism of Tesmilifene can be decreased when combined with Isavuconazonium. Investigational Testosterone The metabolism of Testosterone can be decreased when combined with Isavuconazonium. Approved, Investigational Testosterone cypionate The metabolism of Testosterone cypionate can be decreased when combined with Isavuconazonium. Approved Testosterone enanthate The metabolism of Testosterone enanthate can be decreased when combined with Isavuconazonium. Approved Testosterone propionate The metabolism of Testosterone propionate can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved, Withdrawn Testosterone undecanoate The metabolism of Testosterone undecanoate can be decreased when combined with Isavuconazonium. Approved, Investigational Tetracycline The metabolism of Tetracycline can be decreased when combined with Isavuconazonium. Approved, Vet Approved Tezacaftor The metabolism of Tezacaftor can be decreased when combined with Isavuconazonium. Approved, Investigational Theophylline The metabolism of Theophylline can be decreased when combined with Isavuconazonium. Approved Thiotepa The metabolism of Thiotepa can be decreased when combined with Isavuconazonium. Approved, Investigational Tiagabine The metabolism of Tiagabine can be decreased when combined with Isavuconazonium. Approved, Investigational Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Isavuconazonium. Approved Ticlopidine The metabolism of Isavuconazonium can be decreased when combined with Ticlopidine. Approved Tinidazole The metabolism of Tinidazole can be decreased when combined with Isavuconazonium. Approved, Investigational Tiotropium The metabolism of Tiotropium can be decreased when combined with Isavuconazonium. Approved Tipranavir The metabolism of Tipranavir can be decreased when combined with Isavuconazonium. Approved, Investigational Tocilizumab The serum concentration of Isavuconazonium can be decreased when it is combined with Tocilizumab. Approved Tocofersolan The metabolism of Tocofersolan can be decreased when combined with Isavuconazonium. Approved Tocopherol The metabolism of Tocopherol can be decreased when combined with Isavuconazonium. Approved, Investigational Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Isavuconazonium. Approved, Investigational Tolterodine The metabolism of Tolterodine can be decreased when combined with Isavuconazonium. Approved, Investigational Tolvaptan The serum concentration of Tolvaptan can be increased when it is combined with Isavuconazonium. Approved Topotecan The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium. Approved, Investigational Toremifene The metabolism of Toremifene can be decreased when combined with Isavuconazonium. Approved, Investigational Trabectedin The metabolism of Trabectedin can be decreased when combined with Isavuconazonium. Approved, Investigational Tramadol The metabolism of Tramadol can be decreased when combined with Isavuconazonium. Approved, Investigational Trastuzumab emtansine The metabolism of Trastuzumab emtansine can be decreased when combined with Isavuconazonium. Approved, Investigational Trazodone The metabolism of Trazodone can be decreased when combined with Isavuconazonium. Approved, Investigational Tretinoin The metabolism of Tretinoin can be decreased when combined with Isavuconazonium. Approved, Investigational, Nutraceutical Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Isavuconazonium. Approved, Vet Approved Triazolam The metabolism of Triazolam can be decreased when combined with Isavuconazonium. Approved, Investigational Trimethadione The metabolism of Trimethadione can be decreased when combined with Isavuconazonium. Approved Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Isavuconazonium. Approved, Vet Approved Trimipramine The metabolism of Trimipramine can be decreased when combined with Isavuconazonium. Approved Troglitazone The metabolism of Troglitazone can be decreased when combined with Isavuconazonium. Investigational, Withdrawn Troleandomycin The metabolism of Troleandomycin can be decreased when combined with Isavuconazonium. Approved Udenafil The metabolism of Udenafil can be decreased when combined with Isavuconazonium. Approved, Investigational Ulipristal The serum concentration of Ulipristal can be increased when it is combined with Isavuconazonium. Approved Valbenazine The metabolism of Valbenazine can be decreased when combined with Isavuconazonium. Approved, Investigational Valdecoxib The metabolism of Valdecoxib can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Vandetanib The metabolism of Vandetanib can be decreased when combined with Isavuconazonium. Approved Vanoxerine The metabolism of Vanoxerine can be decreased when combined with Isavuconazonium. Investigational Vardenafil The metabolism of Vardenafil can be decreased when combined with Isavuconazonium. Approved Velpatasvir The metabolism of Velpatasvir can be decreased when combined with Isavuconazonium. Approved, Investigational Vemurafenib The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Isavuconazonium. Approved Venetoclax The metabolism of Venetoclax can be decreased when combined with Isavuconazonium. Approved, Investigational Venlafaxine The metabolism of Isavuconazonium can be decreased when combined with Venlafaxine. Approved Verapamil The metabolism of Isavuconazonium can be decreased when combined with Verapamil. Approved Vicriviroc The metabolism of Vicriviroc can be decreased when combined with Isavuconazonium. Investigational Vilanterol The metabolism of Vilanterol can be decreased when combined with Isavuconazonium. Approved Vilazodone The serum concentration of Vilazodone can be increased when it is combined with Isavuconazonium. Approved Vinblastine The metabolism of Vinblastine can be decreased when combined with Isavuconazonium. Approved Vincristine The metabolism of Vincristine can be decreased when combined with Isavuconazonium. Approved, Investigational Vindesine The serum concentration of Vindesine can be increased when it is combined with Isavuconazonium. Approved, Investigational Vinflunine The metabolism of Vinflunine can be decreased when combined with Isavuconazonium. Approved, Investigational Vinorelbine The metabolism of Vinorelbine can be decreased when combined with Isavuconazonium. Approved, Investigational Vismodegib The metabolism of Vismodegib can be decreased when combined with Isavuconazonium. Approved, Investigational Voriconazole The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Voriconazole. Approved, Investigational Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Isavuconazonium. Approved, Investigational Voxilaprevir The metabolism of Voxilaprevir can be decreased when combined with Isavuconazonium. Approved, Investigational Warfarin The metabolism of Warfarin can be decreased when combined with Isavuconazonium. Approved Yohimbine The metabolism of Yohimbine can be decreased when combined with Isavuconazonium. Approved, Investigational, Vet Approved Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Isavuconazonium. Approved, Investigational Zalcitabine The metabolism of Zalcitabine can be decreased when combined with Isavuconazonium. Approved, Investigational Zaleplon The metabolism of Zaleplon can be decreased when combined with Isavuconazonium. Approved, Illicit, Investigational Zidovudine The metabolism of Zidovudine can be decreased when combined with Isavuconazonium. Approved Zileuton The metabolism of Zileuton can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Ziprasidone The metabolism of Isavuconazonium can be decreased when combined with Ziprasidone. Approved Zolpidem The metabolism of Zolpidem can be decreased when combined with Isavuconazonium. Approved Zomepirac The metabolism of Zomepirac can be decreased when combined with Isavuconazonium. Withdrawn Zonisamide The metabolism of Zonisamide can be decreased when combined with Isavuconazonium. Approved, Investigational Zopiclone The serum concentration of Zopiclone can be increased when it is combined with Isavuconazonium. Approved Zotepine The metabolism of Zotepine can be decreased when combined with Isavuconazonium. Approved, Investigational, Withdrawn Zuclopenthixol The serum concentration of Zuclopenthixol can be increased when it is combined with Isavuconazonium. Approved, Investigational - Food Interactions
- Not Available
References
- General References
- Rybak JM, Marx KR, Nishimoto AT, Rogers PD: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. doi: 10.1002/phar.1652. Epub 2015 Nov 2. [PubMed:26598096]
- Miceli MH, Kauffman CA: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis. 2015 Nov 15;61(10):1558-65. doi: 10.1093/cid/civ571. Epub 2015 Jul 15. [PubMed:26179012]
- External Links
- KEGG Drug
- D10643
- PubChem Compound
- 6918606
- PubChem Substance
- 310264875
- ChemSpider
- 5293801
- ChEBI
- 85978
- ChEMBL
- CHEMBL1183349
- Wikipedia
- Isavuconazole
- FDA label
- Download (851 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Capsule Oral 186 mg/1 Injection, powder, lyophilized, for solution Intravenous 74.4 mg/mL - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) US7459561 No 2000-10-31 2020-10-31 US US6812238 No 2000-10-31 2020-10-31 US
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00516 mg/mL ALOGPS logP 1.73 ALOGPS logP 0.52 ChemAxon logS -5.2 ALOGPS pKa (Strongest Acidic) 12.57 ChemAxon pKa (Strongest Basic) 6.45 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 9 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 159.37 Å2 ChemAxon Rotatable Bond Count 15 ChemAxon Refractivity 193.86 m3·mol-1 ChemAxon Polarizability 71.63 Å3 ChemAxon Number of Rings 5 ChemAxon Bioavailability 0 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- Alpha amino acid esters
- Alternative Parents
- Phenylpropanes / Benzonitriles / Fluorobenzenes / 2,4-disubstituted thiazoles / Imidolactams / Pyridines and derivatives / Aryl fluorides / Triazoles / Heteroaromatic compounds / Carbamate esters show 14 more
- Substituents
- Alpha-amino acid ester / Phenylpropane / Benzonitrile / 2,4-disubstituted 1,3-thiazole / Fluorobenzene / Halobenzene / Aryl fluoride / Aryl halide / Pyridine / Imidolactam show 32 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- organic cation (CHEBI:85978)
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- SubstrateInhibitorInducer
- Curator comments
- Isavuconazonium is a prodrug to Isavuconazole which is the actual CYP3A4 substrate, but it will therefore still participate in CYP3A4 drug interactions when taken.
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Rybak JM, Marx KR, Nishimoto AT, Rogers PD: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. doi: 10.1002/phar.1652. Epub 2015 Nov 2. [PubMed:26598096]
Transporters
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Xenobiotic-transporting atpase activity
- Specific Function
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Gene Name
- ABCB1
- Uniprot ID
- P08183
- Uniprot Name
- Multidrug resistance protein 1
- Molecular Weight
- 141477.255 Da
References
- Miceli MH, Kauffman CA: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis. 2015 Nov 15;61(10):1558-65. doi: 10.1093/cid/civ571. Epub 2015 Jul 15. [PubMed:26179012]
Drug created on March 19, 2008 10:42 / Updated on June 06, 2018 15:19