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Displaying drugs 251 - 275 of 11741 in total

Carvedilol

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Lithium carbonate

Lithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Approved
Matched Description: … Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse …
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Eslicarbazepine acetate

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body....
Approved
Matched Description: … Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active …

Polyethylene glycol 300

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They...
Approved
Matched Description: … It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. ... Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 ... PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hydroxyethyl ethylcellulose

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dichromate

Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …

Digoxin

Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Iupac: … yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a,11-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. ... [A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Clove oil

Clove oil is obtained by extraction from the dried flower buds of the clove plant. Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. It is also found in topical analgesics. Clove oil has shown to exert some antimicrobial activities. The antioxidant and antimicrobial...
Approved
Nutraceutical
Matched Description: … Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. ... The FDA categorizes clove oil as generally recognized as safe (GRAS) for use in dental cement or as a …

Ferric carboxymaltose

Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nickel sulfate

Nickel sulfate is used in allergenic testing.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cobalt chloride

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Matched Iupac: … methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … A cardiac glycoside sometimes used in place of digoxin. ... It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a ... This product is currently available as both an oral tablet and as a powder for intravenous injection. …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Astemizole

Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Approved
Withdrawn
Matched Description: … Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Romidepsin

Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.
Approved
Investigational
Matched Description: … Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Pyrethrum extract

Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species....
Approved
Matched Description: … Pyrethrin refers to a more refined extract of pyrethrum. ... Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species. …
Matched Mixtures name: … Mata Piojos A Pediculicide Low Foaming …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Sodium hydroxide

Sodium hydroxide is also known as lye or soda , or caustic soda . At room temperature, sodium hydroxide is a white crystalline odorless solid that absorbs moisture from the air. It is a synthetically manufactured substance. When dissolved in water or neutralized with acid it releases substantial amounts of...
Approved
Matched Description: … Sodium hydroxide is generally used as a solid or a diluted in a 50% solution. ... It is a synthetically manufactured substance. ... as a pH control agent and follows good manufacturing guidelines [L1967]. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Potassium hydroxide

Potassium hydroxide, also known as lye is an inorganic compound with the chemical formula KOH. Also commonly referred to as caustic potash, it is a potent base that is marketed in several forms including pellets, flakes, and powders. It is used in various chemical, industrial and manufacturing applications. Potassium hydroxide...
Approved
Matched Description: … Potassium hydroxide is used in food to adjust pH, as a stabilizer, and as a thickening agent. ... Potassium hydroxide is also a precursor to other potassium compounds. ... Also commonly referred to as _caustic potash_, it is a potent base that is marketed in several forms …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. ... A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a …
Matched Products: … N/A …

Phenprocoumon

Coumarin derivative that acts as a long-acting oral anticoagulant.
Approved
Investigational
Matched Description: … Coumarin derivative that acts as a long-acting oral anticoagulant. …
Matched Categories: … Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Zanubrutinib

Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival. BTK...
Approved
Investigational
Matched Iupac: … (7S)-2-(4-phenoxyphenyl)-7-[1-(prop-2-enoyl)piperidin-4-yl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Matched Description: … trial whose tumour is entirely or partially destroyed by a drug. ... Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients ... [A187967] BTK is an enzyme that plays a role in oncogenic signalling pathways, promoting the survival …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Risdiplam

Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of SMN2 gene transcription. This mechanism of action is similar to its predecessor nusinersen, the biggest difference being their route of administration: nusinersen...
Approved
Investigational
Matched Iupac: … 7-{4,7-diazaspiro[2.5]octan-7-yl}-2-{2,8-dimethylimidazo[1,2-b]pyridazin-6-yl}-4H-pyrido[1,2-a]pyrimidin …
Matched Description: … to be substantially cheaper than other available SMA therapies,[L15351] risdiplam appears to provide a …

Angiotensin II

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Matched Description: … and affects up to one third of patients in the intensive care unit, the FDA determined that there is a ... Pharmaceutical's Giapreza (angiotensin II) Injection for Intravenouse Infusion for the indication of acting as a …

Fluciclovine (18F)

Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging. The structure of fluciclovine allows it to be uptaken by the tumoral cells by its amino acid transporter without incorporating in the metabolism within the...
Approved
Matched Description: … Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. …

Cantharidin

Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle.[A32891, A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory...
Approved
Investigational
Matched Description: … female beetle as a copulatory gift during mating. ... Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that ... , A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Displaying drugs 251 - 275 of 11741 in total