Displaying drugs 26 - 50 of 796 in total
VA-MENGOC-BC®
VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide of meningococcal group C. As there already exists a polysaccharide-based vaccine against meningococcal disease originating from serogroups A,C,W135, and...
Investigational
Matched Synonyms: … Meningococcal polysaccharide vaccine groups B and C …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Givastomig
Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody.
Investigational
Matched Synonyms: … an anti-Claudin 18.2 and 4.1BB Bispecific Antibody …
Matched Description: … Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody. …
Matched Description: … Givastomig is an anti-Claudin 18.2 and 4.1BB bispecific antibody. …
MM-111
MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.
Investigational
Matched Synonyms: … Antibody bispecific for erbb2 and erbb3 ... Bispecific her2/her3 antibody albumin fusion protein …
Matched Description: … family receptor tyrosine kinases, ERBB2 and ERBB3. ... MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … family receptor tyrosine kinases, ERBB2 and ERBB3. ... MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Benzalkonium
Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent [FDA Label]. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA Label]. This salt is used in a great variety of international pharmaceutical products such...
Approved
Investigational
Matched Description: … Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase ... This salt is used in a great variety of international pharmaceutical products such as eye, ear, and nasal ... When used as an ingredient in antiseptic and disinfectant products however, it is an active antimicrobial …
Matched Mixtures name: … RBX For Men Antibacterial Hand Sanitizer Aloe Vera and Tea Tree Scented ... Whole Wipes ... First aid and Burn …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Primal Blends ... Flower Pelle Bubble Antibacterial Hand Wash ... Personal CARE Antibacterial Foaming Hand Wild Flowers …
Matched Mixtures name: … RBX For Men Antibacterial Hand Sanitizer Aloe Vera and Tea Tree Scented ... Whole Wipes ... First aid and Burn …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Primal Blends ... Flower Pelle Bubble Antibacterial Hand Wash ... Personal CARE Antibacterial Foaming Hand Wild Flowers …
Efprezimod alfa
CD24Fc is a biological immunomodulator originally developed to address graft-versus-host disease in stem cell transplantation in leukemia patients.
Investigational
Matched Synonyms: … Human CD24 and human IgG Fc Fusion Protein …
Matched Description: … CD24Fc is a biological immunomodulator originally developed to address graft-versus-host disease in stem …
Matched Description: … CD24Fc is a biological immunomodulator originally developed to address graft-versus-host disease in stem …
Colloidal oatmeal
Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal material. It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. Phenols are also contained in colloidal oatmeal, which possess antioxidant and anti-inflammatory activities, as well as UV-absorbing activity. Colloidal oatmeal...
Approved
Nutraceutical
Matched Synonyms: … Oat flour ... Oat Kernel Flour ... Avena Sativa (oat) kernel flour …
Matched Description: … Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal ... It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. ... skin irritation and itching due to rashes, eczema, poison ivy, oak, sumac, or insect bites. …
Matched Mixtures name: … Dermavive Shower and Bath Oil …
Matched Products: … Phyllis Golden Hair ... Phyllis Golden Hair Essence ... Skinfix Calm and Nourish Body …
Matched Description: … Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal ... It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. ... skin irritation and itching due to rashes, eczema, poison ivy, oak, sumac, or insect bites. …
Matched Mixtures name: … Dermavive Shower and Bath Oil …
Matched Products: … Phyllis Golden Hair ... Phyllis Golden Hair Essence ... Skinfix Calm and Nourish Body …
Penicillium glaucum
Penicillium glaucum allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, penicillium glaucum ... Molds, rusts and smuts, penicillium glaucus ... Penicillium glaucum whole …
PMC-403
PMC-403 is a novel Tie2-activating antibody being investigated for the treatment of systemic capillary leak syndrome.
Investigational
Matched Synonyms: … a fully human monoclonal antibody that binds and activates the Tie2 receptor …
Matched Description: … leak syndrome. ... PMC-403 is a novel Tie2-activating antibody being investigated for the treatment of systemic capillary …
Matched Description: … leak syndrome. ... PMC-403 is a novel Tie2-activating antibody being investigated for the treatment of systemic capillary …
Allantoin
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains...
Approved
Matched Description: … Allantoin is a substance that is endogenous to the human body and also found as a normal component of ... During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated ... , in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions [A32213]. …
Matched Mixtures name: … Fruit of the Earth Cool Blue Aloe Vera Cooling ... Red Ginseng Snail Gold Serum ... Bubble Cheee Gold Plus Tooth …
Matched Categories: … Basic Ointments and Protectants ... Herbs and Natural Products …
Matched Products: … Sang Leaf Ginseng Collagen ... Atobos Centella and Wash ... Healing Foot and Leg Balm …
Matched Mixtures name: … Fruit of the Earth Cool Blue Aloe Vera Cooling ... Red Ginseng Snail Gold Serum ... Bubble Cheee Gold Plus Tooth …
Matched Categories: … Basic Ointments and Protectants ... Herbs and Natural Products …
Matched Products: … Sang Leaf Ginseng Collagen ... Atobos Centella and Wash ... Healing Foot and Leg Balm …
Chloroxylenol
Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic...
Approved
Matched Description: … disinfection and surgical instruments. ... Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin ... It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. …
Matched Categories: … Antiseptics and Disinfectants ... Phenol and Derivatives …
Matched Products: … Gold and Sudsy ... GOJO Gold and Klean Antimicrobial Ltn Sp ... Highmark Professional Gold and Clean Antimicrobial Ltn Sp …
Matched Categories: … Antiseptics and Disinfectants ... Phenol and Derivatives …
Matched Products: … Gold and Sudsy ... GOJO Gold and Klean Antimicrobial Ltn Sp ... Highmark Professional Gold and Clean Antimicrobial Ltn Sp …
Zinc oxide
Zinc oxide is an inorganic compound used in a number of manufacturing processes. It can be found in rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced...
Approved
Matched Description: … lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and ... It is also widely used to treat a variety of other skin conditions, in products such as baby powder and ... barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments …
Matched Mixtures name: … Sirot Hand and Body Trio Transformative glass Technology Complete Age Resistance Day and Night ... Sirot Hand and Body Trio Transformative Glass Technology Complete Age Resistance Day and Night ... SIROT 24-Hour Hand Care Transformative Glass Technology Age-Fighting Protection Day and Night …
Matched Categories: … Basic Ointments and Protectants ... Basic Powders and Demulcents ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … Whole Body Organic Sunscreen ... Maui Vera Reef Friendly Mineral Sunscreen ... avatara Kom Bu Cha The Simple Shield Balancing Oil-Free Moisturizer SPF 30 …
Matched Mixtures name: … Sirot Hand and Body Trio Transformative glass Technology Complete Age Resistance Day and Night ... Sirot Hand and Body Trio Transformative Glass Technology Complete Age Resistance Day and Night ... SIROT 24-Hour Hand Care Transformative Glass Technology Age-Fighting Protection Day and Night …
Matched Categories: … Basic Ointments and Protectants ... Basic Powders and Demulcents ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … Whole Body Organic Sunscreen ... Maui Vera Reef Friendly Mineral Sunscreen ... avatara Kom Bu Cha The Simple Shield Balancing Oil-Free Moisturizer SPF 30 …
Aluminum sesquichlorohydrate
Aluminum sesquichlorohydrate is an aluminum salt used as an antiperspirant agent, cosmetic astringent and deodorant agent. It works by physically blocking eccrine sweat gland ducts .
Approved
Matched Description: … Aluminum sesquichlorohydrate is an aluminum salt used as an antiperspirant agent, cosmetic astringent and …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Fraicheur The Vert Antiperspirant and Deodorant Roll-ON ... ESIKA FLOWERY Roll-On ... Fraicheur The Vert Deo Bille Antiperspirant …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Fraicheur The Vert Antiperspirant and Deodorant Roll-ON ... ESIKA FLOWERY Roll-On ... Fraicheur The Vert Deo Bille Antiperspirant …
CAM-GM201
Investigational
Matched Synonyms: … rAAV2/1 Hex alpha and beta ... Recombinant adeno-associated viral vector serotype 2/1 encoding human beta-hexosaminidase alpha and beta …
Romilkimab
Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).
Investigational
Matched Synonyms: … Bispecific antibody targeting interleukin 4 (IL-4) and interleukin 13 (IL-13) …
Matched Description: … Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in …
Matched Description: … Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in …
Salicylic acid
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Approved
Investigational
Vet approved
Matched Description: … A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically ... It has bacteriostatic, fungicidal, and keratolytic actions. …
Matched Mixtures name: … Peace Out Acne Day and Night Duo ... Peace Out Acne Day and Night Duo ... Peace Out Acne Day and Night Duo …
Matched Categories: … Salicylic Acid and Derivatives ... Genito Urinary System and Sex Hormones ... sodium salicylate and methenamine …
Matched Products: … Doctor Lead M ... DOCTOR LEAD M 500mL ... TRANS-VER-SAL …
Matched Mixtures name: … Peace Out Acne Day and Night Duo ... Peace Out Acne Day and Night Duo ... Peace Out Acne Day and Night Duo …
Matched Categories: … Salicylic Acid and Derivatives ... Genito Urinary System and Sex Hormones ... sodium salicylate and methenamine …
Matched Products: … Doctor Lead M ... DOCTOR LEAD M 500mL ... TRANS-VER-SAL …
Capsaicin
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent...
Approved
Matched Description: … Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, ... and patch preparations of various strengths; however, it may also be found in some dietary supplements …
Matched Mixtures name: … Satohap Cool and Hot Pads ... Zostrix Hot and Cold Therapy System ... Cajun Hot Ice Muscle and Joint Pain Rub …
Matched Categories: … Basic Lotions and Liniments ... Capsaicin and Similar Agents ... Topical Products for Joint and Muscular Pain …
Matched Products: … MINTED LEAF Heat Therapy Roll-On with Capsaicin and CBD ... Sherman and Clark Pain Relieving ... CareALL Arthritis and Muscle …
Matched Mixtures name: … Satohap Cool and Hot Pads ... Zostrix Hot and Cold Therapy System ... Cajun Hot Ice Muscle and Joint Pain Rub …
Matched Categories: … Basic Lotions and Liniments ... Capsaicin and Similar Agents ... Topical Products for Joint and Muscular Pain …
Matched Products: … MINTED LEAF Heat Therapy Roll-On with Capsaicin and CBD ... Sherman and Clark Pain Relieving ... CareALL Arthritis and Muscle …
Stannous fluoride
Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective...
Approved
Matched Description: … It manages and prevents dental caries and gingivitis by promoting enamel mineralization [A19580], reducing ... compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and ... effect and modulation of the microbial composition of the dental biofilm [A19581]. …
Matched Mixtures name: … Perfect Choice 0.717% Root and Dentin Desens …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Up and Up Anticavity Toothpaste Multi Function ... Sensodyne Sensitivity and Gum Clean and Fresh ... Crest Sensi-Repair and Prevent …
Matched Mixtures name: … Perfect Choice 0.717% Root and Dentin Desens …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Up and Up Anticavity Toothpaste Multi Function ... Sensodyne Sensitivity and Gum Clean and Fresh ... Crest Sensi-Repair and Prevent …
Antihemophilic factor (recombinant), PEGylated
Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product Adynovate [FDA label].
Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one molecule of...
Approved
Investigational
Matched Description: … It has been created to increase the half-life of factor VIII, which decreases dose frequency and decreases ... PEGylation decreases factor VIII clearance and allowing for an increased duration of drug circulation ... 2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 3000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 250 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 3000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 250 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Moroctocog alfa
Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Description: … as a result, leads to easy bruising and bleeding. ... results in the conversion of prothrombin to thrombin, and as a result, leads to the conversion of fibrinogen ... purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Lonoctocog alfa
Approved
Investigational
Matched Products: … AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250IU/VIAL ... AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500IU/VIAL ... AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1000IU/VIAL …
Aloe vera flower
Aloe vera flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Synonyms: … Aloe Vera Flower Extract ... Aloe Barbadensis Flower ... Aloe Flower Extract …
Matched Name: … Aloe vera flower …
Matched Description: … Aloe vera flower is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Aloe vera flower …
Matched Description: … Aloe vera flower is a plant/plant extract used in some OTC (over-the-counter) products. …
Hydrogen peroxide
Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition....
Approved
Vet approved
Matched Description: … whites, and dried egg yolks. ... and gas form for preservative, disinfection and sterilization applications as an oxidative biocide [A32369 ... cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg …
Matched Mixtures name: … SALON CODE Glam Hair Color Glam Rose Gold ... QCare Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System, Q4 …
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … Tooth Whole White ... Primal Elements Hydrogen Peroxide 3 Percent ... Up and Up 3 Hydrogen Peroxide Wipes …
Matched Mixtures name: … SALON CODE Glam Hair Color Glam Rose Gold ... QCare Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System, Q4 …
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … Tooth Whole White ... Primal Elements Hydrogen Peroxide 3 Percent ... Up and Up 3 Hydrogen Peroxide Wipes …
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Approved
Matched Description: … It has bactericidal activity and is used often as a topical disinfectant. ... A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout ... It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as …
Matched Mixtures name: … RBX For Men Antibacterial Hand Sanitizer Aloe Vera and Tea Tree Scented ... Whole Wipes ... whole health Hand Sanitizers 3-pack …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Aloe Vera Leaf Hand Sanitizer ... Every Night Hand Sanitizer with Aloe Vera ... Friuts and Flowers Clean Cotton Waterless Hand Sanitizer …
Matched Mixtures name: … RBX For Men Antibacterial Hand Sanitizer Aloe Vera and Tea Tree Scented ... Whole Wipes ... whole health Hand Sanitizers 3-pack …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Aloe Vera Leaf Hand Sanitizer ... Every Night Hand Sanitizer with Aloe Vera ... Friuts and Flowers Clean Cotton Waterless Hand Sanitizer …
Rurioctocog alfa pegol
Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous or secondary events like trauma...
Approved
Experimental
Matched Description: … Bleeding in joints is a common manifestation of hemophilia A, and bleeding episodes can be severe and ... alfa pegol aims to restore functional levels of factor VIII in patients with hemophilia A to manage and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 1500IU Powder and Solvent for Solution for Injection ... ADYNOVATE 2000IU Powder and Solvent for Solution for Injection ... ADYNOVATE 1000IU Powder and Solvent for Solution for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 1500IU Powder and Solvent for Solution for Injection ... ADYNOVATE 2000IU Powder and Solvent for Solution for Injection ... ADYNOVATE 1000IU Powder and Solvent for Solution for Injection …
RP-72
Investigational
Matched Synonyms: … CXC chemokine receptor types 1 and 2 inhibitor RP72 ... 72 amino acid proprietary recombinant protein antagonist for the CXCR1 and CXCR2 receptors of interleukin …
Displaying drugs 26 - 50 of 796 in total