Zinc oxide

Identification

Name
Zinc oxide
Accession Number
DB09321
Type
Small Molecule
Groups
Approved
Description

Zinc oxide is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water, and it is widely used as an additive in numerous materials and products including rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced synthetically. It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.

Structure
Thumb
Synonyms
  • óxido de cinc
  • oxyde de zinc
  • Zinc (as oxide)
  • Zinc (as zinc oxide)
  • Zinc white
  • Zinci oxydum
  • Zincum oxydatum
  • Zinkoxid
External IDs
C.I. 77947 / C.I. pigment white 4 / CI 77947
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MezincPlaster28.3 %TopicalAbigo Medical AbNot applicableNot applicableCanada
ZincofaxOintment15 %TopicalWarner Lambert Canada Inc.Not applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
100% Pure Argan Oil Moisturizer SPF 30Lotion20 mg/mLTopicalPurity Cosmetics2014-09-032017-05-03Us
100% Pure Sweet Mint Lip Balm SPF 15Stick87 mg/gTopicalPurity Cosmetics2017-05-01Not applicableUs
100% Pure Yerba Mate MIst SPF 30Aerosol, spray120 mg/mLTopicalPurity Cosmetics2017-05-01Not applicableUs
1000 Roses CC Color plus Correct Sheer Nude SPF 30Lotion200 mg/mLTopicalAndalou Naturals2014-03-01Not applicableUs
1000 Roses CC Color Plus Correct Sheer Tan SPF 30Lotion200 mg/mLTopicalAndalou Naturals2014-03-01Not applicableUs
ABC Arbonne Baby Care Sunscreen Broad Spectrum SPF 30Lotion144 mg/mLTopicalArbonne International Llc2014-09-20Not applicableUs
ACCOJE SUNSCREEN (SPF50 Broad Spectrum)Cream4.97 g/100mLTopicalUcl Co., Ltd.2016-02-04Not applicableUs
ACTIVE ARGAN 02.3(TM) PLASMA PRO 50 FEATHERWEIGHT DAY BROAD SPECTRUM SPF 20 WITH PROPRIETARY A.P.I. and ACTIVATED ARGAN COMPLEX(TM)Cream140 mg/mLTopicalSiborg2016-12-01Not applicableUs
Active Daily DefenseCream12 mg/100mLTopicalUrban Skin Solutions2016-07-25Not applicableUs
Active Day Cream With Uv-protectionCream2 kgTopicalBiokosma Sa1998-08-041999-09-11Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BabySpa Shea Butter DiaperCream120 mg/mLTopicalExpro3, Llc2012-07-18Not applicableUs
DDM CalamineLotion160 mg/mLTopicalDiscount Drug Mart2008-01-01Not applicableUs
Desitin Rapid Relief Diaper RashCream130 mg/gTopicalJohnson & Johnson2015-10-20Not applicableUs
Freds CalamineLotion160 mg/mLTopicalFred's1998-03-25Not applicableUs
Health Care CalamineLotion160 mg/mLTopicalGreat Lakes Wholesale, Marketing, and Sales, Inc.2008-01-01Not applicableUs
Mineral Baby SPF 50 Broad SpectrumStick20 g/100gTopicalBell International Laboratories2017-01-01Not applicableUs
Mineral Sport Golden Tint SPF 50 Broad SpectrumStick20 g/100gTopicalBell International Laboratories2017-01-01Not applicableUs
Mineral Sport Stick Untinted SPF 50 Broad SpectrumStick20 g/100gTopicalBell International Laboratories2017-01-01Not applicableUs
Premiere Value CalamineLotion160 mg/mLTopicalChain Drug Consortium2008-01-01Not applicableUs
Rite Aid CalamineLotion160 mg/mLTopicalRite Aid1998-03-25Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
01 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
02 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
03 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
04 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
05 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
06 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
07 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
08 Moisture Foundation SPF 15Zinc oxide (3.9 mg/.5mL) + Octinoxate (3.75 mg/.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-06Not applicableUs
100% Pure Baby Sunscreen SPF 30Zinc oxide (25 mg/g) + Titanium dioxide (80 mg/g)StickTopicalPurity Cosmetics2014-09-092017-05-03Us
100% Pure Everywhere Sunscreen SPF 30Zinc oxide (25 mg/g) + Titanium dioxide (80 mg/g)StickTopicalPurity Cosmetics2014-09-09Not applicableUs
Categories
UNII
SOI2LOH54Z
CAS number
1314-13-2
Weight
Average: 81.408
Monoisotopic: 79.9240612
Chemical Formula
OZn
InChI Key
XLOMVQKBTHCTTD-UHFFFAOYSA-N
InChI
InChI=1S/O.Zn
IUPAC Name
oxozinc
SMILES
O=[Zn]

Pharmacology

Indication

For adjunctive treatment of diaper dermatitis. Also, it can be used to treat minor skin irritations (eg, cuts, burns, and scrapes, poison ivy). Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light.

Structured Indications
Pharmacodynamics

Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.

Mechanism of action

It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.

Absorption

No significant percutaneous absorption from topically applied zinc oxide.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Toxicity

Acute oral toxicity (LD50): 7950 mg/kg [Mouse].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Derry JE, McLean WM, Freeman JB: A study of the percutaneous absorption from topically applied zinc oxide ointment. JPEN J Parenter Enteral Nutr. 1983 Mar-Apr;7(2):131-5. [PubMed:6406699]
  2. MSDS [Link]
  3. product info [Link]
External Links
KEGG Drug
D01170
PubChem Compound
14806
PubChem Substance
310265203
ChemSpider
14122
ChEBI
36560
ChEMBL
CHEMBL1201128
Wikipedia
Zinc_oxide
ATC Codes
C05AX04 — Zinc preparations
AHFS Codes
  • 84:24.12 — Basic Ointments and Protectants
  • 84:24.16 — Basic Powders and Demulcents
  • 84:80.00 — Sunscreen Agents
FDA label
Download (112 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentIntertrigo1
2Active Not RecruitingSupportive CareDermatologic Complications / Neoplasms, Malignant1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
4CompletedTreatmentDiaper Rash1
4CompletedTreatmentHyperpigmentation1
4CompletedTreatmentMelasma1
Not AvailableCompletedPreventionPigmentation From Visible Light1
Not AvailableCompletedTreatmentFoot Dryness in Patients With NIDDM / Foot Transepidermal Water Loss in Patients in NIDDM1
Not AvailableTerminatedTreatmentDiaper Rash1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LotionTopical20 mg/mL
StickTopical87 mg/g
Aerosol, sprayTopical120 mg/mL
SolutionTopical
Cream; kitTopical
LotionTopical144 mg/mL
CreamTopical4.97 g/100mL
CreamTopical140 mg/mL
CreamTopical12 mg/100mL
CreamTopical5.5 g/100g
StickTopical5.5 g/100g
LotionTopical22.5 g/100g
StickTopical4.14 g/18.4g
OintmentTopical3.8 g/100g
PowderTopical9.1 g/100g
OintmentTopical160 mg/g
LipstickTopical8 g/100g
PatchCutaneous; Topical; Transdermal
CreamTopical10 g/100g
SprayTopical10 g/99g
CreamTopical20 g/100g
LotionTopical8.5 g/100g
PowderTopical
CreamTopical17.1 g/57g
CreamTopical10 g/10g
OintmentTopical130 g/g
CreamTopical16.51 g/127g
CreamTopical23.8 g/85g
CreamTopical2.75 g/11g
LotionTopical20 g/100g
OintmentTopical11.3 %
CreamTopical150 mg/g
OintmentTopical16 g/100g
CreamTopical16 g/100g
CreamTopical120 mg/mL
LotionTopical12 g/100mL
CreamTopical18.75 g/100mL
StickTopical8 g/100g
CreamTopical20 g/100mL
StickTopical22.5 g/100g
OintmentTopical18.75 mL/100mL
CreamTopical22.5 g/100mL
CreamTopical10 g/100mL
CreamTopical.113 g/g
PoulticeTopical
PowderTopical20 g/100g
CreamTopical12 %
CreamTopical5.0016 g/100mL
CreamTopical1.92 g/100mL
LotionTopical14 g/100mL
StickTopical15.4 g/100g
EmulsionTopical19 g/100mL
LipstickTopical8.05 g/100g
LotionTopical140 mg/mL
CreamTopical17 mL/100mL
LotionTopical19.7 g/100mL
LotionTopical18 g/100mL
OintmentTopical17.75 g/71g
CreamTopical16 g/113g
CreamTopical40 g/113g
LiquidTopical10 g/100mL
SprayTopical4 g/100g
SprayTopical10 g/100g
PasteTopical45.2 g/113g
CreamTopical14.69 g/113g
CreamTopical12 g/100g
CreamTopical120 mg/g
SuppositoryRectal
OintmentTopical.2 g/g
LotionTopical
StickTopical
CreamTopical20 mg/100mL
CreamTopical.0686 mg/g
OintmentTopical.4 g/g
LotionTopical200 mg/g
OintmentTopical13 kg/100kg
CreamTopical20 %
PasteTopical20 %
CreamTopical.013 g/g
LipstickTopical
LotionTopical66 mg/mL
LotionTopical10 g/100g
LotionTopical17.5 g/100g
OintmentTopical
CreamTopical.9 g/100mL
CreamTopical5 g/100g
LotionTopical95 mg/mL
CreamTopical95 mg/mL
CreamTopical15.25 g/100g
CreamTopical12 g/100mL
CreamTopical15 g/100g
PasteTopical400 mg/g
OintmentTopical400 mg/g
CreamTopical.113 kg/g
CreamTopical.4 g/g
PasteTopical532 mg/g
CreamTopical19 g/100mL
CreamTopical4.9 g/100g
OintmentTopical12 %
CreamTopical96 mg/g
OintmentTopical100 mg/g
CreamTopical
OintmentTopical65 mg/g
OintmentTopical10 g/100g
CreamTopical.01248 g/g
LiquidCutaneous
OintmentTopical19 g/100g
OintmentTopical21 g/100g
PowderTopical15.004 g/100g
LotionTopical22 g/100g
CreamTopical13.8 g/100mL
CreamTopical25 g/100mL
CreamTopical75 g/1000g
CreamTopical60 g/1000g
CreamTopical225 mg/100mL
CreamTopical59.02 g/454g
CreamTopical181.6 g/454g
EmulsionTopical1.1 g/10g
LotionTopical100 mg/mL
CreamTopical16.32 mL/100mL
LotionTopical13.6 g/100mL
CreamTopical168 mg/mL
CreamTopical101 mg/mL
LotionTopical19 g/100g
PatchTopical
LiquidTopical13.8 g/100mL
PowderCutaneous
PatchTopical8.3 g/100g
CreamTopical25 mL/100mL
LiquidTopical.65 mg/130mL
PasteTopical200 mg/mL
CreamTopical.125 mL/mL
LotionTopical160 mg/mL
CreamTopical190 mg/g
LotionTopical190 mg/mL
CreamTopical.07 g/g
PowderTopical.02 g/g
StickCutaneous
CreamTopical13 mg/g
OintmentTopical.1 g/g
PasteOral400 mg/g
CreamTopical1.6 g/20mL
LiquidTopical160 mg/mL
OintmentRectal
OintmentRectal50 mg/g
OintmentTopical150 mg
LotionTopical19 g/100mL
LotionTopical9.3 g/100mL
Spray, suspensionTopical12 g/100mL
CreamTopical.03 g/mL
PowderTopical.0192 g/g
PowderTopical.0291 g/g
LotionTopical13.5 g/100g
PasteTopical25 %
CreamTopical14.5 mg/mL
LiquidTopical1.6 g/100g
CreamTopical.0192 g/g
LiquidTopical.02 g/g
CreamTopical13.0 %
PowderTopical10 %
Kit
PowderTopical100 mg/g
Cream, augmentedTopical
OintmentTopical10 mL/100mL
CreamTopical200 mg/mL
OintmentTopical250 g/1000g
LotionTopical15 g/100mL
LotionTopical.0157 g/mL
PasteTopical
LotionTopical.48 g/30mL
LiquidTopical.016 g/mL
Lotion / shampooTopical
CreamTopical9.45 mg/mL
CreamTopical6.8 g/100mL
OintmentTopical113.6 g/284g
LotionTopical7.9 mg/100mL
CreamTopical21 g/100g
CreamTopical14 g/100mL
SuspensionTopical
OintmentTopical18 g/100g
LotionTopical200 mg/mL
CreamTopical.0098 g/g
CreamTopical400 mg/g
OintmentRectal; Topical
SuppositoryRectal1.7 g/1
CreamTopical50 mg/mL
DressingTopical19.8 g/165g
DressingTopical24.6 g/205g
GelTopical
OintmentTopical96 mg/g
OintmentTopical9.6 g/100g
CreamTopical1.8 g/100g
CreamTopical3.8 g/100g
PasteTopical40 g/100g
PlasterTopical28.3 %
LotionTopical.25 mg/mg
StickTopical17 g/100g
CreamTopical24 mg/g
CreamCutaneous3.5 mL/50mL
CreamCutaneous
CreamTopical105 mg/mL
CreamTopical9.9 g/100g
LotionTopical8.3 g/83g
LotionTopical5.5 g/55g
CreamTopical13 g/100g
CreamTopical7.85 g/50mL
LotionTopical24 g/68mL
CreamTopical24.96 g/100g
LotionTopical22 g/100mL
OintmentTopical8.8 g/88mL
Spray, meteredOral
LotionCutaneous
Kit
LotionTopical182.4 mg/mL
LotionTopical216 mg/mL
GelTopical20 g/100g
CreamTopical.12 mL/mL
Kit; lotionTopical
CreamTopical185 mg/g
LotionTopical185 mg/g
CapsuleOral
CreamTopical17 g/100mL
LipstickTopical10 g/100g
CreamTopical114 mg/mL
CreamTopical250 mg/g
PasteTopical180 mg
PasteTopical25 g/100g
LotionTopical13.0 %
CreamTopical2.4 g/.259mL
OintmentTopical.038 g/g
LotionTopical.13 mg/2.5mL
Capsule, liquid filledOral
TabletOral
Tablet, coatedOral
CreamTopical7.5 g/100g
LotionTopical1 g/5g
LiquidTopical.0098 g/mL
CreamTopical13.5 g/100g
LotionTopical7.5 mL/100mL
CreamTopical.1 g/g
CreamTopical130 mg/g
CreamTopical4.9 g/100mL
CreamTopical18.5 g/100g
StickTopical227.5 mg/g
CreamTopical230 mg/mL
CreamTopical227.5 mg/g
LotionTopical49.5 mg/mL
Kit
CreamTopical4.45 g/100g
DressingTopical
DressingTopical25 g/1
PasteTopical20 g/100g
CreamTopical13 g/100mL
CreamTopical.9 mL/30mL
StickTopical35 mg/g
CreamTopical8 g/90mL
CreamTopical.26 g/1.54g
PlasterTopical
LotionTopical.75 g/5mL
PowderTopical18 g/100g
Tablet, chewableOral
CreamTopical306.1 mg/g
CreamTopical100 mg/g
KitTopical
CreamTopical2 kg
Aerosol, foamTopical140 mg/mL
PowderTopical12 mg/.1g
PowderTopical12 mg/100mg
EmulsionTopical10 g/100mL
LiquidTopical
CreamTopical40 g/100g
PowderTopical5 %
LotionTopical19 g/142g
LotionTopical25 g/142g
PasteTopical12.5 g/100g
LipstickTopical.462 g/4.62g
LotionTopical23.7 g/118.294g
OintmentTopical.085 g/g
OintmentTopical55 mg/g
CreamTopical.0702 mg/g
CreamTopical200 mg/g
Aerosol, foamTopical
CreamTopical223 mg/g
CreamTopical10.8 g/96g
CreamTopical2.94 g/28g
CreamTopical186 mg/mL
LotionTopical20 g/100mL
LiquidTopical8.82 g/90mL
SpongeTopical
EmulsionTopical
CreamTopical220 mg/g
SprayTopical12 g/100mL
StickTopical17 g/100mL
GelTopical186 mg/mL
CreamTopical190 mg/mL
CreamTopical170 mg/mL
CreamTopical43.4 g/177mL
CreamTopical28.9 g/118mL
CreamTopical25 g/100g
LiquidTopical50 mg/mL
LotionTopical12.9 mL/52mL
LotionTopical1.24 mL/5mL
LotionTopical32.3 mL/130mL
SprayTopical
StickTopical20 g/100g
LipstickTopical18 g/100g
CreamTopical882.7 mg/9.1g
Aerosol, sprayTopical
StickTopical24.5 g/100g
LotionTopical30 mg/mL
CreamTopical15 g/100mL
LotionTopical10 g/100mL
CreamTopical100 mg/mL
PasteTopical200 mg/g
CreamTopical.12 g/g
CreamTopical.2 g/g
SprayTopical25 g/100g
CreamTopical1.15 g/40mL
StickTopical22 g/100g
CreamTopical10 %
PasteTopical12.8 g/100g
LotionTopical20 mL/100mL
SprayTopical24 mL/120mL
CreamTopical10 mL/50mL
CreamTopical.135 mg/g
PasteTopical5 mg/cm2
OintmentTopical13 g/100g
OintmentTopical40 g/100g
AerosolTopical
LotionTopical6.87 g/34.35g
PasteTopical125 mg/g
PowderTopical.69 g/3g
Tablet, film coatedOral
Capsule, gelatin coatedOral
PowderTopical2 g/100g
LotionTopical146 mg/mL
CreamTopical14 g/100g
ClothTopical20 g/100g
StickTopical6.5 g/100g
StickTopical7.6 g/100g
CreamTopical1.96 g/100g
CreamTopical22 g/100g
LotionTopical8 g/100g
CreamTopical15 %
OintmentTopical15 %
CreamTopical.2 kg/kg
OintmentTopical1.8 g/100g
OintmentTopical20 g/100g
OintmentTopical200 mg/g
CreamTopical15 g
OintmentTopical20 g
OintmentTopical20 %
CreamTopical186 mg/g
OintmentTopical40 %
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8147852No2008-03-302028-03-30Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.2ChemAxon
pKa (Strongest Basic)-5.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.07 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity1.44 m3·mol-1ChemAxon
Polarizability3 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as transition metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal organides
Sub Class
Transition metal oxides
Direct Parent
Transition metal oxides
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Transition metal oxide / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
zinc molecular entity (CHEBI:36560)

Drug created on November 17, 2015 10:38 / Updated on November 22, 2017 12:38