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Displaying drugs 26 - 50 of 77 in total

Exenatide

Exenatide is a glucagon-like peptide-1 (GLP-1) analog . It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control . Exenatide was given FDA approval on April 28, 2005 . It is available as immediate- and extended-release formulations.[L42685,L42690] Bydureon, the brand...
Approved
Investigational
Matched Description: … It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows ... It is available as immediate- and extended-release formulations. …
Matched Categories: … Fluids and Secretions ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … BYDUREON 2 mg powder and solvent for prolonged-release suspension for injection ... BYDUREON POWDER AND SOLVENT FOR PROLONGED-RELEASE SUSPENSION FOR INJECTION IN PRE-FILLED PEN 2MG …

Chromium nicotinate

Approved
Experimental

Metreleptin

Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy include metabolic abnormalities such as hypertriglyceridemia,...
Approved
Matched Description: … Metreleptin is produced in _E. coli_ and differs from native human leptin by the addition of a methionine ... resistance, reduced HbA1c and fasting glucose, reduced triglycerides, and reductions in food intake. ... Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Lixisenatide

Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Approved
Matched Description: … It is sold by Sanofi-Aventis under the brand name Adlyxin in the US[L763] and Lyxumia in the EU. …
Matched Mixtures name: … LYXUMIA SOLUTION FOR INJECTION IN PRE-FILLED PEN 10MCG AND 20MCG (50mcg/mL and 100mcg/mL) ... LYXUMIA SOLUTION FOR INJECTION IN PRE-FILLED PEN 10MCG AND 20MCG (50mcg/mL and 100mcg/mL) …
Matched Categories: … insulin glargine and lixisenatide ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Sotalol

Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening...
Approved
Matched Description: … injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm ... [L6334] A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous …
Matched Categories: … sotalol and thiazides ... Beta Blocking Agents and Thiazides ... sotalol and acetylsalicylic acid ... Beta Blocking Agents, Non-Selective, and Thiazides …

Glimepiride

First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … increasing the insulin-mediated peripheral glucose uptake. ... resistance in accordance with progressive β cell failure and long-term microvascular and macrovascular ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes …
Matched Mixtures name: … Pioglitazone and Glimepiride ... Pioglitazone and Glimepiride ... Pioglitazone hydrochloride and glimepiride …
Matched Categories: … Insulin Secretagogues ... Alimentary Tract and Metabolism ... glimepiride and pioglitazone ... glimepiride and rosiglitazone …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Description: … Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and ... Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Telmisartan

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to...
Approved
Investigational
Matched Mixtures name: … Telmisartan and Amlodipine ... Telmisartan and Amlodipine ... Telmisartan and Amlodipine …
Matched Categories: … telmisartan and diuretics ... telmisartan and amlodipine ... rosuvastatin and telmisartan ... telmisartan, amlodipine and hydrochlorothiazide ... Angiotensin II receptor blockers (ARBs) and diuretics …

Moxonidine

Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Description: … As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin ... suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and …
Matched Categories: … moxonidine and diuretics …

Macimorelin

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … fat mass (particularly in the abdominal region), decreased lean body mass, osteopenia, dyslipidemia, insulin ... such as AIDS and cancer. ... resistance, and/or glucose intolerance overtime. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Rosuvastatin

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Description: … studies to significantly reduce the risk of development of CVD and all-cause mortality. ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and ... of metabolic reactions involved in the production of several compounds involved in lipid metabolism and …
Matched Mixtures name: … Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe …
Matched Categories: … Alimentary Tract and Metabolism ... rosuvastatin and ramipril ... rosuvastatin and valsartan ... rosuvastatin and ezetimibe ... rosuvastatin and amlodipine …

Mecasermin

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is...
Approved
Investigational
Matched Synonyms: … INSULIN-LIKE GROWTH FACTOR I (HUMAN) ... RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I ... Human somatomedin C …
Matched Description: … Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label ... IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a ... The amino acid sequence of the product is identical to that of endogenous human IGF-1. …
Matched Categories: … Human Insulin-like Growth Factor Analogs ... Recombinant Human Insulin-like Growth Factor-1 ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins …

Tesamorelin

Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and hyperlipidemia associated with antiretroviral therapy for HIV infection.
Approved
Investigational
Matched Synonyms: … N-[(3E)-1-oxo-3-hexenyl]Somatoliberin (human pancreatic islet) …
Matched Description: … Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and hyperlipidemia …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …

Teduglutide

Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that teduglutide...
Approved
Matched Synonyms: … Glucagon-like peptide II (2-glycine) (human) …
Matched Description: … It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Various Alimentary Tract and Metabolism Products ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Pasireotide

Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.
Approved
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … SIGNIFOR LAR(60 MG POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION) ... Signifor LAR 20mg powder and solvent for suspension for injection ... Signifor LAR 40mg powder and solvent for suspension for injection …

Pioglitazone

Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert in vivo with little consequence. The thiazolidinedione class...
Approved
Investigational
Matched Description: … ], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake ... affect numerous metabolic processes, most notably lipid and glucose homeostasis. ... safer and more effective alternatives for patients with type 2 diabetes mellitus. …
Matched Mixtures name: … Pioglitazone and metformin ... Pioglitazone and Glimepiride ... Pioglitazone and Glimepiride …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and pioglitazone ... pioglitazone and alogliptin ... glimepiride and pioglitazone ... pioglitazone and sitagliptin …

Dextrose, unspecified form

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Vet approved
Matched Description: … It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms ... through aerobic or anaerobic respiration and fermentation. ... Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and …
Matched Mixtures name: … Normosol-R and Dextrose ... Normosol-R and Dextrose ... Dextrose and Sodium Chloride …
Matched Products: … Monoject Insulin Reaction Gel 40% …

Chromic nitrate

Approved

Chromium gluconate

Approved

Chromous sulfate

Approved

Dulaglutide

Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA in 2014, and...
Approved
Investigational
Matched Description: … agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and ... [A236070] Dulaglutide was initially approved by the FDA in 2014, and in February 2020 was approved for ... use in patients with T2DM and multiple cardiovascular risk factors for the prevention of cardiovascular …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Liraglutide

Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid...
Approved
Matched Description: … Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as ... [Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine …
Matched Categories: … insulin degludec and liraglutide ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Somapacitan

Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan was granted FDA approval...
Approved
Investigational
Matched Description: … and prolonging the effect so that it requires weekly dosing rather than daily. ... [A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, …
Matched Categories: … Human Growth Hormone Analogs ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists …

Teplizumab

Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … production, impaired glycemic control, and reliance on exogenous insulin. ... an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin ... L44091] Fc-receptors can bind to the "tail-end" anti-CD3 antibodies in an antigen-non-specific manner and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Somatrem

Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disposition of short...
Approved
Investigational
Withdrawn
Matched Description: … Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Displaying drugs 26 - 50 of 77 in total