Displaying drugs 76 - 100 of 14997 in total
Betibeglogene autotemcel
Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Synonyms: … Autologous CD34+ cells encoding βA-T87Q-Globin gene …
Matched Description: … [L42940] β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a ... [A251770,A251785] Betibeglogene autotemcel was approved by the FDA in August 2022 and is the first ex-vivo ... lentiviral vector gene therapy available in the U.S. for the treatment of people with β-thalassemia. …
Matched Categories: … Autologous Hematopoietic Stem Cell-Based Gene Therapy …
Matched Description: … [L42940] β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a ... [A251770,A251785] Betibeglogene autotemcel was approved by the FDA in August 2022 and is the first ex-vivo ... lentiviral vector gene therapy available in the U.S. for the treatment of people with β-thalassemia. …
Matched Categories: … Autologous Hematopoietic Stem Cell-Based Gene Therapy …
Formestane
Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity....
Approved
Investigational
Withdrawn
Matched Synonyms: … 4-OH-A ... 4-hydroxy-4-androstene-3,17-dione ... 4-Hydroxy-delta(4)-androstenedione …
Matched Iupac: … 9bS,11aS)-6-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. ... Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity ... Formestane has poor oral bioavailability, and thus must be administered fortnightly (bi-weekly) by intramuscular …
Matched Iupac: … 9bS,11aS)-6-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. ... Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity ... Formestane has poor oral bioavailability, and thus must be administered fortnightly (bi-weekly) by intramuscular …
Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen
Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.
Approved
Matched Name: … Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen …
Matched Description: … a vaccine. ... Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is …
Matched Description: … a vaccine. ... Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is …
Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine
Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine is used to prevent invasive meningococcal disease, which is caused by bacteria Neisseria meningitidis entering the bloodstream and invading the blood-brain barrier to cause a variety of infections such as septicemia, meningitis, and pneumonia. Several serogroups of N....
Approved
Matched Name: … Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine …
Matched Description: … , marketed as MENVEO, was first approved by the FDA in 2010. ... _ CRM197 protein carrier, resulting in four drug substances contained in each dose of vaccine. ... to prevent invasive meningococcal disease, which is caused by bacteria _Neisseria meningitidis_ entering …
Matched Description: … , marketed as MENVEO, was first approved by the FDA in 2010. ... _ CRM197 protein carrier, resulting in four drug substances contained in each dose of vaccine. ... to prevent invasive meningococcal disease, which is caused by bacteria _Neisseria meningitidis_ entering …
D-glucose
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Investigational
Vet approved
Matched Synonyms: … D-Glucose in linear form …
Matched Description: … a basic health system. ... L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. ... Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and …
Matched Mixtures name: … Acd-A ... Anticoagulant Citrate Dextrose A ACD-A ... Acd A …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … DEXTROSE 5% IN DIS.WATER INJ 500ML ... DEXTROSE 5% IN DIS.WATER INJ 1000ML ... DEXTROSE 10% IN DIS.WATER INJ 500ML …
Matched Description: … a basic health system. ... L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. ... Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and …
Matched Mixtures name: … Acd-A ... Anticoagulant Citrate Dextrose A ACD-A ... Acd A …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … DEXTROSE 5% IN DIS.WATER INJ 500ML ... DEXTROSE 5% IN DIS.WATER INJ 1000ML ... DEXTROSE 10% IN DIS.WATER INJ 500ML …
Voretigene neparvovec
Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune response. This type of virus is vastly used as vectors for gene therapy because they can...
Approved
Matched Synonyms: … Recombinant adeno-associated virus retinal pigment epithelium gene vector AAV2-hRPE65v2 …
Matched Description: … capacity by the removal of *rep* and *cap* and the insertion of the desired gene with its promoter between ... specific region of the human cellular genome localized in the chromosome 19. ... It is not pathogenic and it causes a very mild immune response. …
Matched Description: … capacity by the removal of *rep* and *cap* and the insertion of the desired gene with its promoter between ... specific region of the human cellular genome localized in the chromosome 19. ... It is not pathogenic and it causes a very mild immune response. …
Tofersen
Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene that causes amyotrophic lateral sclerosis (ALS). Although there were various causes of ALS, 2% of ALS cases are due to SOD1 mutations, with more than 200 SOD1 mutations documented.[A259028,A259033] Tofersen was granted accelerated approval from the FDA...
Approved
Investigational
Matched Synonyms: … Antisense Oligonucleotide Inhibitor Of The Expression Of Superoxide Dismutase 1 Gene ... METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP …
Matched Description: … Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene ... accelerated approval from the FDA on April 25, 2023, as the first treatment for adults with ALS caused by ... [L46133] Tofersen demonstrated efficacy in reducing the concentration of SOD1 in CSF and of neurofilament …
Matched Description: … Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene ... accelerated approval from the FDA on April 25, 2023, as the first treatment for adults with ALS caused by ... [L46133] Tofersen demonstrated efficacy in reducing the concentration of SOD1 in CSF and of neurofilament …
Allantoin
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains...
Approved
Matched Synonyms: … (2,5-Dioxo-4-imidazolidinyl)urea ... 2,5-Dioxo-4-imidazolidinyl-urea ... 4-ureido-2,5-imidazolidinedione …
Matched Iupac: … (2,5-dioxoimidazolidin-4-yl)urea …
Matched Description: … It is a major metabolic intermediate in most organisms. ... The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about ... Allantoin is a substance that is endogenous to the human body and also found as a normal component of …
Matched Mixtures name: … Hands First 4 in 1 ... Alegria Neo ... Dr.g Whitening Fortifier By Egf …
Matched Products: … Miracle GYN (4 Tablets) ... Gene 16 Whitening Factor ... ATOMU Essence A …
Matched Iupac: … (2,5-dioxoimidazolidin-4-yl)urea …
Matched Description: … It is a major metabolic intermediate in most organisms. ... The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about ... Allantoin is a substance that is endogenous to the human body and also found as a normal component of …
Matched Mixtures name: … Hands First 4 in 1 ... Alegria Neo ... Dr.g Whitening Fortifier By Egf …
Matched Products: … Miracle GYN (4 Tablets) ... Gene 16 Whitening Factor ... ATOMU Essence A …
Triptorelin
Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels...
Approved
Vet approved
Matched Synonyms: … Luteinizing hormone-releasing factor (pig), 6-D-tryptophan …
Matched Iupac: … hydroxyphenyl)propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamide ... pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4- ... )-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4- …
Matched Description: … Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH) ... Serum testosterone concentrations may fall to levels typically observed in surgically castrated men. ... After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production …
Matched Products: … Triptofem 0,1 mg/ml Injektionslösung in einer Fertigspritze ... Decapeptyl Depot - Retardmikrokapseln und Suspensionsmittel in Einmalspritzen …
Matched Iupac: … hydroxyphenyl)propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamide ... pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4- ... )-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4- …
Matched Description: … Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH) ... Serum testosterone concentrations may fall to levels typically observed in surgically castrated men. ... After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production …
Matched Products: … Triptofem 0,1 mg/ml Injektionslösung in einer Fertigspritze ... Decapeptyl Depot - Retardmikrokapseln und Suspensionsmittel in Einmalspritzen …
Dapiprazole
Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Approved
Matched Synonyms: … 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine …
Matched Iupac: … 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine …
Matched Description: … It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. …
Matched Iupac: … 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine …
Matched Description: … It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. …
Cyd dengue virus serotype 4 live (attenuated) antigen
Approved
Matched Name: … Cyd dengue virus serotype 4 live (attenuated) antigen …
Interferon alfa-2b
Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Approved
Matched Synonyms: … Intron A ... Intron A (Interferon α2b) …
Matched Description: … A type I interferon consisting of 165 amino acid residues with arginine in position 23. ... This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes …
Matched Mixtures name: … Intron A ... Intron A ... Intron A - Kit (pws+diluent) 3000000iu/vial …
Matched Products: … Intron A ... Intron A - Liq 5000000iu/ml ... Intron A Inj 3000000unit/vial …
Matched Description: … A type I interferon consisting of 165 amino acid residues with arginine in position 23. ... This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes …
Matched Mixtures name: … Intron A ... Intron A ... Intron A - Kit (pws+diluent) 3000000iu/vial …
Matched Products: … Intron A ... Intron A - Liq 5000000iu/ml ... Intron A Inj 3000000unit/vial …
Cyclosporine
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products...
Approved
Investigational
Vet approved
Matched Synonyms: … Cyclosporin A …
Matched Iupac: … (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28 …
Matched Description: … [A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now ... available in various products by Novartis (previously known as Sandoz). ... Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Products: … Cyclosporine A ... Nail Cyclosporin-A ... MODUSIK-A OFTENO …
Matched Iupac: … (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28 …
Matched Description: … [A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now ... available in various products by Novartis (previously known as Sandoz). ... Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Products: … Cyclosporine A ... Nail Cyclosporin-A ... MODUSIK-A OFTENO …
Catridecacog
Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential...
Approved
Matched Synonyms: … Factor XIII A-Subunit (Recombinant) ... Coagulation Factor XIII A-Subunit (recombinant) ... Blood Coagulation Factor XIII (Synthetic Human A-Chain Precursor) …
Matched Description: … When activated by thrombin at the site of injury, the FXIII A2B2 pro-enzyme is cleaved resulting in activation ... It is subsequently isolated by homogenization of cells and purification by several chromatography steps ... Factor XIII is long (5-11 days), prophylactic therapy with the replacement of FXIII can be given every 4- …
Matched Description: … When activated by thrombin at the site of injury, the FXIII A2B2 pro-enzyme is cleaved resulting in activation ... It is subsequently isolated by homogenization of cells and purification by several chromatography steps ... Factor XIII is long (5-11 days), prophylactic therapy with the replacement of FXIII can be given every 4- …
Glatiramer
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Synonyms: … (T,G)-A-L …
Matched Description: … [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. ... immunomodulatory effects and reduces the relapse rate of relapsing-remitting multiple sclerosis (RRMS) by ... [A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a …
Matched Products: … Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze ... Copaxone 40 mg/ml Injektionslösung in einer Fertigspritze ... Copaxobene 20 mg/ml Injektionslösung in einer Fertigspritze …
Matched Description: … [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. ... immunomodulatory effects and reduces the relapse rate of relapsing-remitting multiple sclerosis (RRMS) by ... [A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a …
Matched Products: … Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze ... Copaxone 40 mg/ml Injektionslösung in einer Fertigspritze ... Copaxobene 20 mg/ml Injektionslösung in einer Fertigspritze …
Isotretinoin
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Synonyms: … Neovitamin A acid ... 13-cis-Vitamin A acid …
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. ... the iPLEDGE program in the United States. ... [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under …
Matched Categories: … Retinoids for Topical Use in Acne …
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. ... the iPLEDGE program in the United States. ... [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under …
Matched Categories: … Retinoids for Topical Use in Acne …
Selpercatinib
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including cabozantinib, ponatinib, sorafenib, sunitinib, and vandetanib, have shown efficacy in RET-driven cancers, their...
Approved
Investigational
Matched Synonyms: … -yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile ... 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3 …
Matched Iupac: … -yl}pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile ... 6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3 …
Matched Description: … [L13604] Selpercatinib is also approved by the European Commission. ... It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. ... Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs …
Matched Iupac: … -yl}pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile ... 6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3 …
Matched Description: … [L13604] Selpercatinib is also approved by the European Commission. ... It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. ... Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs …
Omacetaxine mepesuccinate
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate...
Approved
Investigational
Matched Synonyms: … 1-[(1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-H]pyrrolo[2,1-b][ ... 3]benzazepin-1-yl] 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate ... CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE (ESTER) …
Matched Iupac: … (19)-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate ... (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(20),4,13,15 …
Matched Description: … by the FDA. ... protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies ... Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Matched Iupac: … (19)-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate ... (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(20),4,13,15 …
Matched Description: … by the FDA. ... protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies ... Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Nadofaragene firadenovec
Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). It was approved by the FDA on December 2022 for the treatment of high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without...
Approved
Investigational
Matched Synonyms: … Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon alpha-2b) gene …
Matched Description: … It is the first gene therapy approved by the FDA for the treatment of bladder cancer. ... Compared to [pembrolizumab], a smaller proportion of patients experienced grade 3-4 adverse events (4% ... The localized expression of this gene induces anti-tumor effects. …
Matched Categories: … Cellular and Gene Therapy …
Matched Description: … It is the first gene therapy approved by the FDA for the treatment of bladder cancer. ... Compared to [pembrolizumab], a smaller proportion of patients experienced grade 3-4 adverse events (4% ... The localized expression of this gene induces anti-tumor effects. …
Matched Categories: … Cellular and Gene Therapy …
Gramicidin D
Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino...
Approved
Matched Synonyms: … Gramicidin A …
Matched Iupac: … methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl]-2-{2-[(2S)-2-formamido-3-methylbutanamido]acetamido}-4- …
Matched Description: … topical antibiotic and is also found in Polysporin ophthalmic solution. ... Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making ... amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a …
Matched Iupac: … methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl]-2-{2-[(2S)-2-formamido-3-methylbutanamido]acetamido}-4- …
Matched Description: … topical antibiotic and is also found in Polysporin ophthalmic solution. ... Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making ... amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Synonyms: … 4-amino-10-methylfolic acid ... 4-amino-N(10)-methylpteroylglutamic acid ... N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Description: … Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis ... or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma. ... [A180322] Because of these effects, methotrexate is often used to treat inflammation caused by arthritis …
Matched Categories: … OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … METOTREXATO 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE ... METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Description: … Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis ... or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma. ... [A180322] Because of these effects, methotrexate is often used to treat inflammation caused by arthritis …
Matched Categories: … OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … METOTREXATO 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE ... METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Clarithromycin
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Synonyms: … 6-O-methylerythromycin A …
Matched Iupac: … }-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy ... (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy …
Matched Description: … synthesis by binding to the bacterial 50S ribosomal subunit. ... Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein …
Matched Products: … MACROMYCIN GRÁNULOS PARA RECONSTITUIR A SUSPENSIÓN ORAL ... ROLICYTIN® 250 MG/5 ML POLVO PARA RECONSTITUIR A SUSPENSION ORAL ... CLARITROMICINA 250MG/5ML GRANULOS PARA RECONSTITUIR A SUSPENSION ORAL. …
Matched Iupac: … }-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy ... (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy …
Matched Description: … synthesis by binding to the bacterial 50S ribosomal subunit. ... Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein …
Matched Products: … MACROMYCIN GRÁNULOS PARA RECONSTITUIR A SUSPENSIÓN ORAL ... ROLICYTIN® 250 MG/5 ML POLVO PARA RECONSTITUIR A SUSPENSION ORAL ... CLARITROMICINA 250MG/5ML GRANULOS PARA RECONSTITUIR A SUSPENSION ORAL. …
Primaquine
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of...
Approved
Matched International brands: … Neo-Quipenyl …
Matched Synonyms: … 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline ... 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline ... 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline …
Matched Description: … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale ... there is a potential for re-introduction of malaria. ... malarias following treatment with a blood schizontocide. …
Matched Products: … NEO QUIPENYL® …
Matched Synonyms: … 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline ... 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline ... 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline …
Matched Description: … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale ... there is a potential for re-introduction of malaria. ... malarias following treatment with a blood schizontocide. …
Matched Products: … NEO QUIPENYL® …
Dopamine
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Approved
Matched Synonyms: … 4-(2-aminoethyl)catechol ... 4-(2-aminoethyl)pyrocatechol ... 4-(2-aminoethyl)-1,2-benzenediol …
Matched Iupac: … 4-(2-aminoethyl)benzene-1,2-diol …
Matched Description: … Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating ... A family of receptors (receptors, dopamine) mediate its action. ... One of the catecholamine neurotransmitters in the brain. …
Matched Mixtures name: … Dopamine Hydrochloride in Dextrose ... Dopamine Hydrochloride in Dextrose ... Dopamine Hydrochloride in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Monoamine Oxidase A Substrates …
Matched Products: … Dopamine HCl Inj 4% ... Dopamine Hci In 5% Dextrose ... Dopamine Hydrochloride in Dextrose …
Matched Iupac: … 4-(2-aminoethyl)benzene-1,2-diol …
Matched Description: … Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating ... A family of receptors (receptors, dopamine) mediate its action. ... One of the catecholamine neurotransmitters in the brain. …
Matched Mixtures name: … Dopamine Hydrochloride in Dextrose ... Dopamine Hydrochloride in Dextrose ... Dopamine Hydrochloride in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Monoamine Oxidase A Substrates …
Matched Products: … Dopamine HCl Inj 4% ... Dopamine Hci In 5% Dextrose ... Dopamine Hydrochloride in Dextrose …
Acenocoumarol
Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients...
Approved
Investigational
Matched Synonyms: … 3-(alpha-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin ... 3-(alpha-(4'-Nitrophenyl)-beta-acetylethyl)-4-hydroxycoumarin ... 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one …
Matched Iupac: … 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one …
Matched Description: … Acenocoumarol is a coumarin derivative used as an anticoagulant. ... Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. …
Matched Categories: … 4-Hydroxycoumarins ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …
Matched Products: … Sintrom 4 mg Tabletten …
Matched Iupac: … 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one …
Matched Description: … Acenocoumarol is a coumarin derivative used as an anticoagulant. ... Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. …
Matched Categories: … 4-Hydroxycoumarins ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …
Matched Products: … Sintrom 4 mg Tabletten …
Displaying drugs 76 - 100 of 14997 in total