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Displaying drugs 76 - 100 of 10290 in total

Difluprednate

Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Approved
Matched Categories: … Immunosuppressive Agents ... Corticosteroids, Potent (Group III) …

Avelumab

Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … [A261496] Avelumab was first approved by the FDA on March 23, 2017. …
Matched Categories: … Antineoplastic Agents ... Antineoplastic Agents, Immunological ... Antineoplastic and Immunomodulating Agents …

Dibenzepin

Dibenzepin is approved for use in Europe.
Approved
Matched Description: … Dibenzepin is approved for use in Europe. …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Neurotoxic agents ... Agents that produce hypertension ... Central Nervous System Agents …

Repaglinide

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood...
Approved
Investigational
Matched Description: … that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents ... Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes ... Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. …
Matched Categories: … Blood Glucose Lowering Agents ... Hypoglycemia-Associated Agents …

Drotaverine

Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). It is a benzylisoquinoline derivative that is structurally related to papaverine, although it displays more potent antispasmodic activities than papaverine. Drotaverine has been used in the symptomatic treatment of various spastic conditions, such as gastrointestinal diseases, biliary dyskinesia, and...
Approved
Investigational
Matched Description: … Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). ... It is approved for use in Thailand as oral tablets or intramuscular injections.[L22689] ... [A231619] Drotaverine is not approved by the FDA, European Medicines Agency, or Health Canada. …
Matched Categories: … Autonomic Agents ... Cardiovascular Agents ... Vasodilating Agents ... Sensory System Agents ... Central Nervous System Agents …

Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast …
Matched Categories: … Antineoplastic Agents ... Myelosuppressive Agents ... Immunosuppressive Agents ... Cardiotoxic antineoplastic agents ... Antineoplastic and Immunomodulating Agents …

Methylergometrine

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Approved
Matched Description: … A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) …
Matched Categories: … Uterotonic agents ... Agents that produce hypertension ... Reproductive Control Agents …

Sutilain

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from Bacillus subtilis and it is available as a cream-colored odorless powder. One gram of sutilain powder contains 250,000...
Approved
Withdrawn
Matched Description: … Sutilain is a member of the keratase family which includes agents such as papain. ... [T169] Sutilain was developed by Abbott and FDA approved on June 12, 1969. …

Acetohydroxamic acid

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics...
Approved
Matched Description: … In the urine, it acts as an antagonist of the bacterial enzyme urease. …

Protriptyline

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive...
Approved
Matched Description: … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. ... The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression ... Adrenergic Agents ... Neurotoxic agents …

Antazoline

Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.
Approved
Matched Categories: … Anti-Allergic Agents ... Histamine Agents ... QTc Prolonging Agents ... Neurotransmitter Agents ... Moderate Risk QTc-Prolonging Agents …

Alclofenac

Alclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979.
Approved
Withdrawn
Matched Categories: … Nephrotoxic agents ... Antirheumatic Agents ... Anti-Inflammatory Agents ... Sensory System Agents ... Agents causing hyperkalemia …

Secnidazole

Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Description: … [A245503, A245508] In September 2017, FDA approved secnidazole under the market name Solosec for the …
Matched Categories: … Anti-Infective Agents ... Antiparasitic Agents …

Zidovudine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator...
Approved
Matched Description: … by an azido group. ... A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced …
Matched Categories: … Anti-HIV Agents ... Antiviral Agents ... Anti-Infective Agents ... Anti-Retroviral Agents ... Agents Causing Muscle Toxicity …

Tetradecyl hydrogen sulfate (ester)

Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins . Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties ... Also noted was an unspecified number of episodes of epidermal necrosis without significant long-term …

Minoxidil

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Approved
Investigational
Matched Description: … A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance …
Matched Categories: … Antihypertensive Agents ... Hypotensive Agents ... Cardiovascular Agents ... Vasodilating Agents ... Skin and Mucous Membrane Agents …

Iohexol

Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Approved
Matched Description: … Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography …
Matched Categories: … Iodinated Contrast Agents ... Agents that reduce seizure threshold …

Flurandrenolide

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Approved
Matched Description: … It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive …
Matched Categories: … Corticosteroids, Potent (Group III) ... Anti-Inflammatory Agents ... Immunosuppressive Agents …

Anthrax vaccine

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to Bacillus anthracis. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis...
Approved
Matched Description: … [L47526] It is considered one of the most likely agents to be used in a biological attack. ... [L47561] There are currently 2 anthrax vaccines approved by the FDA: BioThrax in August 15, 2016 and ... It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain …

Ketoconazole

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation...
Approved
Investigational
Matched Description: … [A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in ... A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents ... Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal …
Matched Categories: … Antifungal Agents ... Anti-Infective Agents ... Agents causing hyperkalemia ... Hepatotoxic Agents ... QTc Prolonging Agents …

Metipranolol

A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Approved
Matched Description: … It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent. …
Matched Categories: … Adrenergic Agents ... Autonomic Agents ... Antiarrhythmic agents ... Hypotensive Agents ... Cardiovascular Agents …

Elranatamab

Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb, each of which contributes one heavy chain and one light chain to drug structure. The resulting 4-chain bispecific...
Approved
Investigational
Matched Description: … [L47820] Elranatamab was also approved by the European Commission on December 8, 2023.[L50437] ... a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an ... anti-BCMA mAb and an anti-CD3 mAb,[A261060] each of which contributes one heavy chain and one light …

Remimazolam

Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid...
Approved
Investigational
Matched Description: … Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation ... trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents ... A214852,A214857] Remimazolam was the first "soft" benzodiazepine analog to be developed[A214862] and was approved …
Matched Categories: … GABA Agents ... Tranquilizing Agents …

Iodide

Iodide has been investigated for the treatment of Goiter, Nodular.
Approved
Experimental

Anser anser feather

Anser anser feather is used in allergenic testing.
Approved
Displaying drugs 76 - 100 of 10290 in total