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Displaying drugs 101 - 125 of 2596 in total

Brexucabtagene autoleucel

Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib and acalabrutinib, the prognosis for MCL patients remains poor and those that relapse...
Approved
Matched Description: … Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified ... More recently, chimeric antigen receptor (CAR) T cell therapies have been developed that modify a ... [A216188] Similar to [axicabtagene ciloleucel], brexucabtagene autoleucel employs a murine anti-CD19 …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Antineoplastic Agents ... Antineoplastic Agents, Immunological ... Amino Acids, Peptides, and Proteins ... Antineoplastic cell and gene therapy …

Crizotinib

Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers...
Approved
Investigational
Matched Iupac: … 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine …
Matched Description: … Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase ... used to detect ALK and ROS1 rearrangements. ... and genetic resistance mechanisms crizotinib is prone to. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Antineoplastic Agents ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Bradycardia-Causing Agents ... QTc Prolonging Agents …

Ziprasidone

Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior. These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers. Luckily, several treatment options for psychotic disorders have been...
Approved
Matched Iupac: … 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one …
Matched Description: … [A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower ... abuse, and can significantly impact the quality of life of patients and caregivers. ... Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior …
Matched Categories: … Antidepressive Agents ... Dopamine Agents ... Antipsychotic Agents ... Anticholinergic Agents ... Serotonin Agents …
Matched Products: … Truemed Group LLC …

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Synonyms: … 1-Butyl-3-tosylurea ... 1-Butyl-3-(p-tolylsulfonyl)urea ... 1-p-Toluenesulfonyl-3-butylurea …
Matched Iupac: … 3-butyl-1-(4-methylbenzenesulfonyl)urea …
Matched Description: … Tolbutamide and its metabolites are excreted in urine (75-85%) and feces. ... It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea ... increase the number and sensitivity of insulin receptors. …
Matched Categories: … Diagnostic Agents ... Alimentary Tract and Metabolism ... Blood Glucose Lowering Agents ... Hypoglycemia-Associated Agents ... Genito Urinary System and Sex Hormones …

Flunarizine

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Approved
Matched Synonyms: … 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine …
Matched Iupac: … 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine …
Matched Description: … Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 ... peripheral origin, and as an adjuvant in the therapy of epilepsy. ... effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Antiarrhythmic agents ... Histamine Agents ... Agents causing hyperkalemia ... Cardiovascular Agents …

Methsuximide

Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Approved
Matched Synonyms: … 1,3-Dimethyl-3-phenylsuccinimide ... 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine ... (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion …
Matched Iupac: … 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione …
Matched Categories: … Antiarrhythmic agents ... Agents causing hyperkalemia ... Bradycardia-Causing Agents ... QTc Prolonging Agents ... Central Nervous System Agents …

Tetryzoline

Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties. Available since the 1950s, tetryzoline is a selective α1-receptor agonist that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most...
Approved
Matched Description: … Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral ... [A231769] Available since the 1950s, tetryzoline is a selective α1-receptor agonist [A231774 ... Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, …
Matched Mixtures name: … Murine Tears Plus 3 ... ISCHEMOL A ... ISCHEMOL A …
Matched Categories: … Decongestants and Antiallergics ... Compounds used in a research, industrial, or household setting ... Autonomic Agents ... Cardiovascular Agents ... Vasoconstrictor Agents …
Matched Products: … Foster and Thrive Original Formula Eye Drops ... Walgreens Eye Drops Original 15mL and twin pack …

Ceftriaxone

Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges , eyes , and inner ear . Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone...
Approved
Matched Iupac: … (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1,2,5,6 ... -tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic …
Matched Description: … [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the ... Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. ... meninges[A215582], eyes[A215647], and inner ear[A215627]. …
Matched Mixtures name: … CEF-3 INJECTION IM (1G) ... CEF-3 INJECTION IM (1G) ... CEF-3 INJECTION IM (250MG) …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Nephrotoxic agents …
Matched Products: … Ceftriaxone and Dextrose ... CEFTRIAXONA 1000 MG POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE. ... CEF-3 INJECTION 1V (1G) …

Edetic acid

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Description: … A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. ... It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition ... Compounds used in a research, industrial, or household setting ... Chelating Agents ... Hematologic Agents ... Sequestering Agents …

Tromethamine

An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed,...
Approved
Matched Description: … cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used ... It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Tapentadol

Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011....
Approved
Matched Synonyms: … 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol ... PHENOL, 3-((1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL)- …
Matched Iupac: … 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol …
Matched Description: … Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. ... It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake. …
Matched Categories: … Antidepressive Agents ... Adrenergic Agents ... Serotonin Agents ... Sensory System Agents ... Neurotransmitter Agents …

Cetrorelix

Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Iupac: … (4-chlorophenyl)-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido ... ]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]pentanamido]-4-methylpentanamide ... carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-5-(carbamoylamino)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3- …
Matched Description: … Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). …
Matched Categories: … Fertility Agents ... Fertility Agents, Female ... Reproductive Control Agents ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins …
Matched Products: … CETROTIDE 3 MG. ... Cetrotide 0.25 mg powder and solvent for solution for injection ... CETROTIDE 3 MG ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADET …

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Iupac: … 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. ... of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and ... Nisoldipine may be used in alone or in combination with other agents in the management of hypertension …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Antiarrhythmic agents ... Antihypertensive Agents ... Agents causing hyperkalemia ... Hypotensive Agents …

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly ... It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Nephrotoxic agents ... Antirheumatic Agents ... Agents causing hyperkalemia …

Ethanol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Approved
Matched Description: … It has bactericidal activity and is used often as a topical disinfectant. ... A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout ... It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as …
Matched Mixtures name: … Nox-A-Sting ... Soothe-A-sting ... Soothe-A-Sting …
Matched Categories: … Antiseptics and Disinfectants ... Compounds used in a research, industrial, or household setting ... Anti-Infective Agents ... Neurotoxic agents ... Agents Causing Muscle Toxicity …
Matched Products: … Physicians Group Hand Sanitizer ... Physicians Group Hand Sanitizer Gel ... Beauty Industry Group Hand Sanitizer …

Dimercaptosuccinic acid

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting ... Chelating Agents ... Protective Agents ... Sequestering Agents …

Methenamine

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Approved
Vet approved
Matched Description: … Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. …
Matched Salts cas: … 34317-08-3 ... 72962-49-3 …
Matched Mixtures name: … Methenamine and Sodium Salicylate ... Methenamine and Sodium Salicylate (nsaid) ... Disinfectant(Model III)Sanitizer Hand And Surface …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Urinary Acidifying Agents ... Anti-Infective Agents, Urinary …

Loracarbef

Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Approved
Investigational
Withdrawn
Matched Iupac: … (6R,7S)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin …
Matched Salts cas: … 121961-22-6 …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Nephrotoxic agents …

Lomitapide

Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Approved
Investigational
Matched Description: … Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Hepatotoxic Agents ... Hypolipidemic Agents ... Lipid Modifying Agents ... Lipid Modifying Agents, Plain …

Fluconazole

Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Description: … superficial fungal infections in a variety of tissues. ... This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. ... Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and …
Matched Categories: … Antifungal Agents ... Anti-Infective Agents ... Imidazole and Triazole Derivatives ... Triazole and tetrazole derivatives ... Agents causing hyperkalemia …
Matched Products: … CANDIDIN 50 MG KAPSÜL, 3 ADET …

Alprazolam

Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse...
Approved
Illicit
Investigational
Matched Synonyms: … 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine …
Matched Iupac: … 12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. ... ketoconazole and itraconazole. ... of the drug which may lead to coma and death. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepines and benzodiazepine derivatives ... GABA Agents ... Anti-Anxiety Agents ... Tranquilizing Agents …
Matched Products: … XANAX XR EXTENDED-RELEASE TABLET 3 mg …

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized...
Approved
Investigational
Matched Iupac: … 4R)-4-[(1R,3aS,3bR,4S,5aS,7R,9aS,9bS,11aR)-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by ... a minor fraction of the human bile acid pool. ... [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary …
Matched Categories: … Cholelitholytic Agents ... Gastrointestinal Agents ... Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives …

Oseltamivir

Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which...
Approved
Matched Synonyms: … Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate ... 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha …
Matched Iupac: … ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate …
Matched Description: … prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. ... "core" drug to a "complementary" drug, due to limited cost-effectiveness. ... that early antiviral treatment can shorten the duration of fever and illness symptoms, and may reduce …
Matched Categories: … Antiviral Agents ... Anti-Infective Agents …

Linezolid

Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically,...
Approved
Investigational
Matched Synonyms: … N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide …
Matched Iupac: … N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide …
Matched Description: … [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered ... Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive ... Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most …
Matched Categories: … Antidepressive Agents ... Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Serotonin Agents ... Anti-Bacterial Agents ... Anti-Infective Agents …

Etanercept

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1....
Approved
Investigational
Matched Description: … ), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA). ... Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell ... [L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antirheumatic Agents ... Anti-Inflammatory Agents ... Agents reducing cytokine levels ... Immunosuppressive Agents …
Matched Products: … Truemed Group LLC ... Enbrel Solution for Injection in a Pre-filled Pen 50mg ... Enbrel Solution for Injection in a Pre-filled Syringe 50mg …
Displaying drugs 101 - 125 of 2596 in total