Identification

Name
Fluconazole
Accession Number
DB00196  (APRD00327)
Type
Small Molecule
Groups
Approved
Description

Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem]

Structure
Thumb
Synonyms
  • 2-(2,4-DIFLUOROPHENYL)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol
  • 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
  • Biozole
  • Elazor
  • Fluconazol
  • Fluconazolum
  • Triflucan
External IDs
UK-49,858 / UK-49858
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act FluconazoleTablet50 mgOralActavis Pharma Company2007-12-03Not applicableCanada
Act FluconazoleTablet100 mgOralActavis Pharma Company2007-12-03Not applicableCanada
DiflucanTablet200 mg/1OralPd Rx Pharmaceuticals, Inc.1990-01-29Not applicableUs
DiflucanTablet150 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc1990-01-29Not applicableUs
DiflucanTablet150 mg/1OralA S Medication Solutions1990-01-292017-06-20Us
DiflucanTablet200 mg/1OralRoerig1990-01-29Not applicableUs
DiflucanTablet150 mg/1OralRoerig1990-01-29Not applicableUs
DiflucanTablet100 mg/1OralRemedy Repack2013-02-192017-03-01Us
DiflucanTablet50 mg/1OralRoerig1990-01-29Not applicableUs
DiflucanPowder, for suspension350 mg/35mLOralRoerig1993-12-23Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fluconazoleTablet200 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-fluconazoleTablet100 mgOralApotex Corporation1998-10-13Not applicableCanada
Apo-fluconazoleTablet50 mgOralApotex Corporation1998-10-13Not applicableCanada
FluconazoleTablet200 mg/1OralNorth Star Rx Llc2008-10-07Not applicableUs16714 0693 01 nlmimage10 b549dace
FluconazolePowder, for suspension40 mg/mLOralCitron Pharma LLC2009-09-18Not applicableUs
FluconazoleTablet150 mg/1OralMed Vantx, Inc.2004-07-29Not applicableUs
FluconazoleTablet50 mg/1OralLucid Pharma Llc2008-10-07Not applicableUs
FluconazoleInjection2 mg/mLIntravenousWest Ward Pharmaceutical2012-01-30Not applicableUs
FluconazoleTablet50 mg/1OralDr Reddy's Laboratories2014-06-20Not applicableUs
FluconazoleTablet200 mg/1OralMylan Pharmaceuticals2013-02-26Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fluconazole-150Capsule150 mgOralApotex Corporation2000-03-20Not applicableCanada
Bio-fluconazoleCapsule150 mgOralBiomed PharmaNot applicableNot applicableCanada
CanesoralCapsule150 mgOralBayer2010-03-10Not applicableCanada
Co Fluconazole-150Capsule150 mgOralCobalt Laboratories2009-07-21Not applicableCanada
Diflucan OneCapsule150 mgOralPfizer Laboratories Div Pfizer Inc.1995-12-31Not applicableCanada
Dom-fluconazoleCapsule150 mgOralDominion PharmacalNot applicableNot applicableCanada
FluconazoleCapsule150 mgOralSorres Pharma Inc2009-06-172014-06-20Canada
FluconazoleCapsule150 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
FluconazoleCapsule150 mgOralPharmel IncNot applicableNot applicableCanada
Fluconazole 150Capsule150 mgOralTaro Pharmaceuticals, Inc.Not applicableNot applicableCanada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
FluconazoleTablet150 mg/1OralPreferreed Pharmaceuticals Inc.2017-10-31Not applicableUs
FluconazoleTablet200 mg/1OralDirectrx2017-11-01Not applicableUs
International/Other Brands
Diflucan / Elazor / Flucazol / Flucostat / Flunizol / Pritenzol / Trican / Triflucan
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Canesoral Combi-pakFluconazole (150 mg) + Clotrimazole (1 %)Capsule; CreamOral; Topical; VaginalBayer2010-03-10Not applicableCanada
Clotrimaderm-fluconazole Combi-packFluconazole (150 mg) + Clotrimazole (1 %)Capsule; Cream; KitOral; TopicalTaro Pharmaceuticals, Inc.2017-02-14Not applicableCanada
Clotrimazole-fluconazole Combi-packFluconazole (150 mg) + Clotrimazole (1 %)Capsule; Cream; KitOral; TopicalTaro Pharmaceuticals, Inc.2017-02-03Not applicableCanada
Monicure ComboFluconazole (150 mg) + Miconazole nitrate (2 %)Capsule; Cream; KitOral; TopicalInsight Pharmaceuticals2012-10-25Not applicableCanada
Categories
UNII
8VZV102JFY
CAS number
86386-73-4
Weight
Average: 306.2708
Monoisotopic: 306.104065446
Chemical Formula
C13H12F2N6O
InChI Key
RFHAOTPXVQNOHP-UHFFFAOYSA-N
InChI
InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
IUPAC Name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
SMILES
OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1

Pharmacology

Indication

For the treatment of fungal infections.

Structured Indications
Pharmacodynamics

Fluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane.

Mechanism of action

Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

TargetActionsOrganism
ALanosterol 14-alpha demethylase
inhibitor
Yeast
Absorption

90%

Volume of distribution
Not Available
Protein binding

11 to 12%

Metabolism

Hepatic

Route of elimination

In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug.

Half life

30 hours (range 20-50 hours)

Clearance
  • 0.23 mL/min/Kg [adults]
  • 0.18 mL/min/Kg [In premature newborns within 36 hours of birth]
  • 0.22 mL/min/Kg [In premature newborns 6 days old]
  • 0.33 mL/min/Kg [In premature newborns 12 days old]
  • 0.4 mL/min/kg [9 Months-13 yearsreceiving single-oral 2 mg/kg]
  • 0.51 mL/min/Kg [9 Months-13 yearsreceiving single-oral 8 mg/kg]
  • 0.49 mL/min/Kg [5-15 yearsreceiving multiple IV 2 mg/kg]
  • 0.59 mL/min/Kg [5-15 yearsreceiving multiple IV 4 mg/kg]
  • 0.66 mL/min/Kg [5-15 yearsreceiving multiple IV 8 mg/kg]
Toxicity

Symptoms of overdose include hallucinations and paranoid behavior.

Affected organisms
  • Fungi
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbemaciclibThe metabolism of Abemaciclib can be decreased when combined with Fluconazole.Approved
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Fluconazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Fluconazole.Approved, Investigational
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Fluconazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Fluconazole.Approved
AcetohexamideThe serum concentration of Acetohexamide can be increased when it is combined with Fluconazole.Investigational, Withdrawn
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Fluconazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Fluconazole.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Fluconazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Fluconazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Fluconazole.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Fluconazole.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Fluconazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Fluconazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Fluconazole.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Fluconazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Fluconazole.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Fluconazole.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Fluconazole.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Fluconazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Fluconazole.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Fluconazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Fluconazole.Approved
AmiodaroneFluconazole may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Fluconazole.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fluconazole.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Fluconazole.Approved, Vet Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Fluconazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Fluconazole.Approved
AmrinoneThe serum concentration of Amrinone can be increased when it is combined with Fluconazole.Approved
AnagrelideFluconazole may increase the QTc-prolonging activities of Anagrelide.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Fluconazole.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fluconazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Fluconazole.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Fluconazole.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Fluconazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Fluconazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Fluconazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fluconazole.Approved, Investigational
Arsenic trioxideFluconazole may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherFluconazole may increase the QTc-prolonging activities of Artemether.Approved
AsenapineFluconazole may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Fluconazole.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Fluconazole.Approved, Investigational
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Fluconazole.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fluconazole.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fluconazole.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Fluconazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Fluconazole.Approved
AzelnidipineThe serum concentration of Azelnidipine can be increased when it is combined with Fluconazole.Approved, Investigational
AzimilideThe serum concentration of Azimilide can be increased when it is combined with Fluconazole.Investigational
AzithromycinFluconazole may increase the QTc-prolonging activities of Azithromycin.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Fluconazole.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Fluconazole.Approved
BedaquilineFluconazole may increase the QTc-prolonging activities of Bedaquiline.Approved
BencyclaneThe serum concentration of Bencyclane can be increased when it is combined with Fluconazole.Experimental
BenidipineThe serum concentration of Benidipine can be increased when it is combined with Fluconazole.Approved, Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Fluconazole.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Fluconazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Fluconazole.Approved
BepridilThe serum concentration of Bepridil can be increased when it is combined with Fluconazole.Approved, Withdrawn
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Fluconazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Fluconazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Fluconazole.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Fluconazole.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Fluconazole.Approved, Withdrawn
BortezomibThe metabolism of Bortezomib can be decreased when combined with Fluconazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fluconazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fluconazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fluconazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fluconazole.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Fluconazole.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Fluconazole.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Fluconazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Fluconazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Fluconazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fluconazole.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Fluconazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Fluconazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Fluconazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Fluconazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Fluconazole.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Fluconazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Fluconazole.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Fluconazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Fluconazole.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Fluconazole.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Fluconazole.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Fluconazole.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be decreased when combined with Fluconazole.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fluconazole.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Fluconazole.Approved
CarboxyamidotriazoleThe serum concentration of Carboxyamidotriazole can be increased when it is combined with Fluconazole.Investigational
CarbutamideThe serum concentration of Carbutamide can be increased when it is combined with Fluconazole.Experimental
CariprazineThe metabolism of Cariprazine can be decreased when combined with Fluconazole.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Fluconazole.Approved
CaroverineThe serum concentration of Caroverine can be increased when it is combined with Fluconazole.Experimental
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Fluconazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Fluconazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Fluconazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Fluconazole.Approved, Vet Approved
CeritinibFluconazole may increase the QTc-prolonging activities of Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Fluconazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Fluconazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Fluconazole.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Fluconazole.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Fluconazole.Approved, Illicit
ChloroquineFluconazole may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Fluconazole.Approved
ChlorpromazineFluconazole may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Chlorpropamide can be increased when it is combined with Fluconazole.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Fluconazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Fluconazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Fluconazole.Approved, Investigational
CilnidipineThe serum concentration of Cilnidipine can be increased when it is combined with Fluconazole.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fluconazole.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Fluconazole.Approved
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Fluconazole.Approved, Investigational
CiprofloxacinFluconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fluconazole.Approved, Investigational, Withdrawn
CitalopramFluconazole may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Fluconazole.Approved
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Fluconazole.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Fluconazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Fluconazole.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Fluconazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Fluconazole.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Fluconazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Fluconazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Fluconazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Fluconazole.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Fluconazole resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Fluconazole.Approved, Illicit
ClorindioneThe serum concentration of Clorindione can be increased when it is combined with Fluconazole.Experimental
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Fluconazole.Approved, Illicit
ClozapineThe metabolism of Clozapine can be decreased when combined with Fluconazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fluconazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Fluconazole.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Fluconazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fluconazole.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Fluconazole.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Fluconazole.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Fluconazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Fluconazole.Approved
CrizotinibFluconazole may increase the QTc-prolonging activities of Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Fluconazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Fluconazole.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fluconazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Fluconazole.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Fluconazole.Approved
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Fluconazole.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Fluconazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Fluconazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Fluconazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Fluconazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Fluconazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Fluconazole.Approved, Investigational
DarodipineThe serum concentration of Darodipine can be increased when it is combined with Fluconazole.Experimental
DarunavirThe metabolism of Darunavir can be decreased when combined with Fluconazole.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Fluconazole.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Fluconazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Fluconazole.Approved
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Fluconazole.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Fluconazole.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Fluconazole.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Fluconazole.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Fluconazole.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Fluconazole.Approved
DexlansoprazoleThe serum concentration of Dexlansoprazole can be increased when it is combined with Fluconazole.Approved
DexrabeprazoleThe serum concentration of Dexrabeprazole can be increased when it is combined with Fluconazole.Experimental
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Fluconazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Fluconazole.Approved, Illicit, Investigational, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Fluconazole.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Fluconazole.Approved, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Fluconazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Fluconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Fluconazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Fluconazole.Approved, Investigational
DigoxinThe metabolism of Digoxin can be decreased when combined with Fluconazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Fluconazole.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Fluconazole.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.Approved
DiphenadioneThe serum concentration of Diphenadione can be increased when it is combined with Fluconazole.Experimental
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Fluconazole.Approved
DisopyramideFluconazole may increase the QTc-prolonging activities of Disopyramide.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Fluconazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Fluconazole.Approved, Investigational
DoconexentThe metabolism of Doconexent can be decreased when combined with Fluconazole.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fluconazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Fluconazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fluconazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Fluconazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Fluconazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Fluconazole.Approved
DotarizineThe serum concentration of Dotarizine can be increased when it is combined with Fluconazole.Investigational
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Fluconazole.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Fluconazole.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fluconazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Fluconazole.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fluconazole.Approved, Illicit
DronedaroneFluconazole may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolFluconazole may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Fluconazole.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Fluconazole.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Fluconazole.Approved, Investigational
EfonidipineThe serum concentration of Efonidipine can be increased when it is combined with Fluconazole.Approved
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Fluconazole.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fluconazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fluconazole.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Fluconazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Fluconazole.Approved, Vet Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Fluconazole.Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Fluconazole.Approved, Investigational
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Fluconazole.Approved
EperisoneThe serum concentration of Eperisone can be increased when it is combined with Fluconazole.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Fluconazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fluconazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Fluconazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Fluconazole.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Fluconazole.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Fluconazole.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Fluconazole.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Fluconazole.Approved, Investigational
ErythromycinFluconazole may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramFluconazole may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Fluconazole.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Fluconazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Fluconazole.Approved, Investigational
EstramustineThe metabolism of Estramustine can be decreased when combined with Fluconazole.Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Fluconazole.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Fluconazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Fluconazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Fluconazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Fluconazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Fluconazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Fluconazole.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Fluconazole.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Fluconazole.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Fluconazole.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Fluconazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Fluconazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Fluconazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Fluconazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fluconazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Fluconazole.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Fluconazole.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Fluconazole.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Fluconazole.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fluconazole.Approved, Investigational
FendilineThe serum concentration of Fendiline can be increased when it is combined with Fluconazole.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Fluconazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fluconazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Fluconazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Fluconazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Fluconazole.Approved, Investigational
FlecainideFluconazole may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fluconazole.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Fluconazole.Investigational
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Fluconazole.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Fluconazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Fluconazole.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Fluconazole.Approved
FluoxetineFluconazole may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolFluconazole may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Fluconazole.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Fluconazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Fluconazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Fluconazole.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be decreased when combined with Fluconazole.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Fluconazole.Approved
FormoterolThe metabolism of Formoterol can be decreased when combined with Fluconazole.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Fluconazole.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Fluconazole.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Fluconazole.Approved, Investigational
GabapentinThe serum concentration of Gabapentin can be increased when it is combined with Fluconazole.Approved, Investigational
Gadobenic acidFluconazole may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Fluconazole.Approved
GallopamilThe serum concentration of Gallopamil can be increased when it is combined with Fluconazole.Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Fluconazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Fluconazole.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Fluconazole.Approved
GemifloxacinFluconazole may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GlibornurideThe serum concentration of Glibornuride can be increased when it is combined with Fluconazole.Investigational, Withdrawn
GliclazideThe serum concentration of Gliclazide can be increased when it is combined with Fluconazole.Approved
GlimepirideThe serum concentration of Glimepiride can be increased when it is combined with Fluconazole.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Fluconazole.Approved
GliquidoneThe serum concentration of Gliquidone can be increased when it is combined with Fluconazole.Approved, Investigational
GlisoxepideThe serum concentration of Glisoxepide can be increased when it is combined with Fluconazole.Approved, Investigational
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Fluconazole.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Fluconazole.Approved
GoserelinFluconazole may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronFluconazole may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Fluconazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Fluconazole.Investigational, Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Fluconazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fluconazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Fluconazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Fluconazole.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Fluconazole.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Fluconazole.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fluconazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Fluconazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Fluconazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Fluconazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fluconazole.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Fluconazole.Approved
IbutilideFluconazole may increase the QTc-prolonging activities of Ibutilide.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Fluconazole.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Fluconazole.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Fluconazole resulting in a loss in efficacy.Approved
IloperidoneFluconazole may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fluconazole.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Fluconazole.Approved, Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Fluconazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Fluconazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Fluconazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Fluconazole.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Fluconazole.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Fluconazole.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Fluconazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Fluconazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Fluconazole.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Fluconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Fluconazole.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Fluconazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Fluconazole.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fluconazole.Approved
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Fluconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fluconazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fluconazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Fluconazole.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Fluconazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Fluconazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Fluconazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Fluconazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Fluconazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Fluconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Fluconazole.Approved, Vet Approved
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Fluconazole.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Fluconazole.Approved
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Fluconazole.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Fluconazole.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Fluconazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Fluconazole.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Fluconazole.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Fluconazole.Approved, Investigational
LenvatinibFluconazole may increase the QTc-prolonging activities of Lenvatinib.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Fluconazole.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Fluconazole.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Fluconazole.Approved, Investigational
LeuprolideFluconazole may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Fluconazole.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Fluconazole.Approved
LevofloxacinFluconazole may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Fluconazole.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Fluconazole.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Fluconazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Fluconazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Fluconazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Fluconazole.Approved, Vet Approved
LidoflazineThe serum concentration of Lidoflazine can be increased when it is combined with Fluconazole.Experimental
LisurideThe metabolism of Lisuride can be decreased when combined with Fluconazole.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fluconazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Fluconazole.Approved
LopinavirFluconazole may increase the QTc-prolonging activities of Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Fluconazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Fluconazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Fluconazole.Approved, Investigational
LosartanThe serum concentration of Losartan can be decreased when it is combined with Fluconazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fluconazole.Approved, Investigational
LumefantrineFluconazole may increase the QTc-prolonging activities of Lumefantrine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Fluconazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fluconazole.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Fluconazole.Approved
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be increased when it is combined with Fluconazole.Approved, Vet Approved
ManidipineThe serum concentration of Manidipine can be increased when it is combined with Fluconazole.Approved, Investigational
MaravirocThe metabolism of Maraviroc can be decreased when combined with Fluconazole.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Fluconazole.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Fluconazole.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Fluconazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Fluconazole.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Fluconazole.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Fluconazole.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Fluconazole.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Fluconazole.Approved, Illicit
MestranolThe metabolism of Mestranol can be decreased when combined with Fluconazole.Approved
MetahexamideThe serum concentration of Metahexamide can be increased when it is combined with Fluconazole.Experimental
MethadoneFluconazole may increase the QTc-prolonging activities of Methadone.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Fluconazole.Illicit, Withdrawn
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Fluconazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Fluconazole.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Fluconazole.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Fluconazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Fluconazole.Approved
MetoprololThe metabolism of Metoprolol can be decreased when combined with Fluconazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Fluconazole.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Fluconazole.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Fluconazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Fluconazole.Approved, Investigational
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Fluconazole.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Fluconazole.Approved, Illicit
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Fluconazole.Approved
MifepristoneMifepristone may increase the QTc-prolonging activities of Fluconazole.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Fluconazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Fluconazole.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Fluconazole.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Fluconazole.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Fluconazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Fluconazole.Approved, Investigational
MoxifloxacinFluconazole may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Fluconazole.Approved, Investigational
NaftopidilThe serum concentration of Naftopidil can be increased when it is combined with Fluconazole.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fluconazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Fluconazole.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Fluconazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Fluconazole.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Fluconazole.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Fluconazole.Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Fluconazole.Approved, Investigational
NetupitantThe metabolism of Netupitant can be decreased when combined with Fluconazole.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Fluconazole.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fluconazole.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Fluconazole.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fluconazole.Approved
NiguldipineThe serum concentration of Niguldipine can be increased when it is combined with Fluconazole.Experimental
NilotinibFluconazole may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NiludipineThe serum concentration of Niludipine can be increased when it is combined with Fluconazole.Experimental
NilutamideThe metabolism of Nilutamide can be decreased when combined with Fluconazole.Approved
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Fluconazole.Approved, Investigational
NimesulideThe serum concentration of Nimesulide can be increased when it is combined with Fluconazole.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fluconazole.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Fluconazole.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fluconazole.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Fluconazole.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Fluconazole.Approved, Investigational
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Fluconazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Fluconazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Fluconazole.Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Fluconazole.Investigational
OfloxacinFluconazole may increase the QTc-prolonging activities of Ofloxacin.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fluconazole.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Fluconazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Fluconazole.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Fluconazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Fluconazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Fluconazole.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Fluconazole.Approved
OtiloniumThe serum concentration of Otilonium can be increased when it is combined with Fluconazole.Experimental, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Fluconazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Fluconazole.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Fluconazole.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Fluconazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Fluconazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Fluconazole.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Fluconazole.Approved
PaliperidoneFluconazole may increase the QTc-prolonging activities of Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Fluconazole.Approved, Investigational
PanobinostatFluconazole may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Fluconazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Fluconazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Fluconazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Fluconazole.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Fluconazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Fluconazole.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fluconazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Fluconazole.Approved
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Fluconazole.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Fluconazole.Approved
PerflutrenFluconazole may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Fluconazole.Approved, Investigational
PermethrinThe metabolism of Permethrin can be decreased when combined with Fluconazole.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Fluconazole.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Fluconazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Fluconazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Fluconazole.Withdrawn
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Fluconazole.Approved, Investigational
PhenobarbitalThe metabolism of Phenobarbital can be decreased when combined with Fluconazole.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Fluconazole.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Fluconazole.Approved, Investigational
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Fluconazole.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fluconazole.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Fluconazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Fluconazole.Approved, Investigational
PimozideFluconazole may increase the arrhythmogenic activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Fluconazole.Withdrawn
PinaveriumThe serum concentration of Pinaverium can be increased when it is combined with Fluconazole.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Fluconazole.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Fluconazole.Approved, Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Fluconazole.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Fluconazole.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Fluconazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Fluconazole.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Fluconazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Fluconazole.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Fluconazole.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Fluconazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Fluconazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Fluconazole.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Fluconazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fluconazole.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be increased when it is combined with Fluconazole.Approved, Illicit, Investigational
PrenylamineThe serum concentration of Prenylamine can be increased when it is combined with Fluconazole.Withdrawn
PrimaquineFluconazole may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe metabolism of Primidone can be decreased when combined with Fluconazole.Approved, Vet Approved
ProcainamideFluconazole may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Fluconazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Fluconazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Fluconazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Fluconazole.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fluconazole.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be decreased when combined with Fluconazole.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Fluconazole.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Fluconazole.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Fluconazole.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Fluconazole.Approved, Illicit
QuetiapineFluconazole may increase the QTc-prolonging activities of Quetiapine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Fluconazole.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Fluconazole.Approved
QuinineFluconazole may increase the QTc-prolonging activities of Quinine.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Fluconazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Fluconazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Fluconazole.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Fluconazole.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fluconazole.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Fluconazole.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Fluconazole.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Fluconazole.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Fluconazole.Approved
RibociclibThe risk or severity of QTc prolongation can be increased when Ribociclib is combined with Fluconazole.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Fluconazole.Approved
RifampicinThe metabolism of Rifampicin can be decreased when combined with Fluconazole.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Fluconazole.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Fluconazole.Approved, Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Fluconazole.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Fluconazole.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Fluconazole.Approved
RisedronateThe serum concentration of Risedronate can be increased when it is combined with Fluconazole.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Fluconazole.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Fluconazole.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Fluconazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Fluconazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Fluconazole.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Fluconazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Fluconazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Fluconazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Fluconazole.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Fluconazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Fluconazole.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Fluconazole.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Fluconazole.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Fluconazole.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Fluconazole.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Fluconazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fluconazole.Approved
SaquinavirFluconazole may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fluconazole.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Fluconazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Fluconazole.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Fluconazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Fluconazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Fluconazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fluconazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fluconazole.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fluconazole.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fluconazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Fluconazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Fluconazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Fluconazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fluconazole.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Fluconazole.Approved, Investigational
SotalolFluconazole may increase the QTc-prolonging activities of Sotalol.Approved
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Fluconazole.Approved
SucralfateSucralfate can cause a decrease in the absorption of Fluconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Fluconazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Fluconazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Fluconazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Fluconazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Fluconazole.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Fluconazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Fluconazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Fluconazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Fluconazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Fluconazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Fluconazole.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fluconazole.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fluconazole.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Fluconazole.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Fluconazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Fluconazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Fluconazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Fluconazole.Experimental
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Fluconazole.Approved, Withdrawn
TelavancinFluconazole may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinFluconazole may increase the QTc-prolonging activities of Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Fluconazole.Approved
TemsirolimusThe serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Fluconazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Fluconazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Fluconazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Fluconazole.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Fluconazole.Withdrawn
TerodilineThe serum concentration of Terodiline can be increased when it is combined with Fluconazole.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Fluconazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Fluconazole.Approved, Investigational
TetrabenazineFluconazole may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Fluconazole.Approved, Vet Approved
TetrahydropalmatineThe serum concentration of Tetrahydropalmatine can be increased when it is combined with Fluconazole.Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Fluconazole.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Fluconazole.Approved, Vet Approved
ThioridazineFluconazole may increase the QTc-prolonging activities of Thioridazine.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Fluconazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Fluconazole.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Fluconazole.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Fluconazole.Approved
TimololThe metabolism of Timolol can be decreased when combined with Fluconazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Fluconazole.Approved, Investigational
TioclomarolThe serum concentration of Tioclomarol can be increased when it is combined with Fluconazole.Experimental
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Fluconazole.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Fluconazole.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Fluconazole.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Fluconazole.Approved, Investigational
TolazamideThe serum concentration of Tolazamide can be increased when it is combined with Fluconazole.Approved
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Fluconazole.Approved
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be increased when it is combined with Fluconazole.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Fluconazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fluconazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Fluconazole.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Fluconazole.Approved
ToremifeneFluconazole may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fluconazole.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Fluconazole.Approved, Investigational
TranilastThe serum concentration of Tranilast can be increased when it is combined with Fluconazole.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Fluconazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Fluconazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Fluconazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Fluconazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Fluconazole.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Fluconazole.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Fluconazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Fluconazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Fluconazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Fluconazole.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Fluconazole.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Fluconazole.Approved, Experimental
UdenafilThe metabolism of Udenafil can be decreased when combined with Fluconazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fluconazole.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Fluconazole.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Fluconazole.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Fluconazole.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Fluconazole.Approved, Investigational
VandetanibFluconazole may increase the QTc-prolonging activities of Vandetanib.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Fluconazole.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Fluconazole.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Fluconazole.Approved
VemurafenibFluconazole may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Fluconazole.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Fluconazole.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fluconazole.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Fluconazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Fluconazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fluconazole.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Fluconazole.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fluconazole.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Fluconazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fluconazole.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Fluconazole.Approved, Investigational
VinpocetineThe serum concentration of Vinpocetine can be increased when it is combined with Fluconazole.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Fluconazole.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fluconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Fluconazole.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Fluconazole.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fluconazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
XylometazolineThe serum concentration of Xylometazoline can be increased when it is combined with Fluconazole.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Fluconazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Fluconazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Fluconazole.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Fluconazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Fluconazole.Approved, Investigational
ZiconotideThe serum concentration of Ziconotide can be increased when it is combined with Fluconazole.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Fluconazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Fluconazole.Approved, Investigational, Withdrawn
ZiprasidoneFluconazole may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Fluconazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Fluconazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Fluconazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fluconazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Fluconazole.Approved, Investigational
Food Interactions
  • Take without regard to meals.

References

Synthesis Reference
US4404216
General References
Not Available
External Links
Human Metabolome Database
HMDB14342
KEGG Drug
D00322
PubChem Compound
3365
PubChem Substance
46505735
ChemSpider
3248
BindingDB
25817
ChEBI
46081
ChEMBL
CHEMBL106
Therapeutic Targets Database
DAP000628
PharmGKB
PA449653
HET
TPF
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Fluconazole
ATC Codes
J02AC01 — FluconazoleD01AC15 — FluconazoleJ01RA07 — Azithromycin, fluconazole and secnidazole
AHFS Codes
  • 08:14.08 — Azoles
PDB Entries
1ea1 / 2ij7 / 2wuz / 2wv2 / 2wx2 / 3khm / 3l4d / 4wmz / 4zdz / 4ze3
show 4 more
FDA label
Download (16.9 KB)
MSDS
Download (73.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAdvanced Solid Tumors1
1Active Not RecruitingTreatmentCardio-respiratory arrest / Infections, Fungal1
1CompletedNot AvailableHealthy Volunteers2
1CompletedNot AvailableMetabolic Detoxication, Phase I1
1CompletedBasic ScienceAlzheimer's Disease (AD)1
1CompletedBasic ScienceDrug Interactions1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceTumors, Solid1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentBacterial Infections / Human Immunodeficiency Virus (HIV) Infections / Mycoses1
1CompletedTreatmentEndometriosis / Prostate Cancer1
1CompletedTreatmentHealthy Participants1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentHealthy Volunteers / Pulmonary Disease, Chronic Obstructive1
1CompletedTreatmentCandidiasis infection / Human Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentInvasive Aspergillosis1
1CompletedTreatmentCandidiasis infection1
1RecruitingTreatmentGraft Versus Host Disease (GVHD) / Transplantation, Stem Cell1
1RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Primary Mediastinal Lymphoma1
1RecruitingTreatmentNeoplasms1
1WithdrawnBasic ScienceHealthy Volunteers1
1WithdrawnTreatmentMalignant Lymphomas1
1, 2CompletedDiagnosticHealthy Volunteers1
1, 2CompletedTreatmentHIV Associated Neurocognitive Disorders (HAND)1
1, 2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis, Cryptococcal1
2CompletedBasic ScienceVery Low Birth Weight Infant1
2CompletedPreventionIntra-abdominal Perforation1
2CompletedTreatmentBlastomycosis / Histoplasmosis / Sporotrichosis1
2CompletedTreatmentCandidemia / Candidiasis, Invasive / Mycoses1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis, Cryptococcal2
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Oral Candidiasis1
2CompletedTreatmentMeningitis, Cryptococcal1
2CompletedTreatmentMoniliasis, Vulvovaginal / Mycoses / Vaginitis, Monilial / Vulvovaginal Candidiasis / Yeast Infections1
2CompletedTreatmentSporotrichosis1
2CompletedTreatmentVulvovaginal Candidiasis2
2CompletedTreatmentVulvovaginal Candidiasis / Vulvovaginitis / Yeast Infection Vaginal / Yeast Infections1
2Not Yet RecruitingTreatmentHuman Immunodeficiency Virus (HIV) / Meningitis / Meningitis streptococcal / Meningoencephalitis1
2RecruitingTreatmentCandida Vulvovaginitis1
2RecruitingTreatmentCandidemia / Candidiasis, Invasive / Fungaemia / Infections, Fungal / Mycoses1
2RecruitingTreatmentCrohn's Disease (CD)1
2TerminatedDiagnosticHyperlipidemias1
2TerminatedTreatmentCrohn's Disease Aggravated1
2TerminatedTreatmentCryptococcal Infection Disseminated1
2, 3Active Not RecruitingTreatmentHuman Immunodeficiency Virus (HIV) / Meningitis, Cryptococcal1
2, 3CompletedTreatmentHead and Neck Carcinoma / Infection NOS / Oral Complications1
2, 3CompletedTreatmentMinor burns1
2, 3Not Yet RecruitingTreatmentCandidiasis infection1
2, 3RecruitingTreatmentMinor burns1
3Active Not RecruitingSupportive CareAdult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Childhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Minimally Differentiated Myeloid Leukemia (M0) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myeloid Leukemia in Remission / Childhood Acute Myelomonocytic Leukemia (M4) / Infections, Fungal / Neutropenias / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3Active Not RecruitingSupportive CareHematopoietic/Lymphoid Cancer / Infections, Fungal1
3CompletedPreventionAcute Appendicitis / Perforated Gastroduodenal Ulcer / Small intestinal obstruction1
3CompletedPreventionBacterial Diseases / Other Mycoses / Sexually Transmitted Infections (STIs)1
3CompletedPreventionCandidiasis infection / Human Immunodeficiency Virus (HIV) Infections / Mycoses1
3CompletedPreventionLeukopenia1
3CompletedPreventionMycoses / Transplantation, Liver1
3CompletedPreventionCandidiasis infection1
3CompletedSupportive CareCancers1
3CompletedTreatmentAspergillosis / Candidiasis infection / Fungaemia / Mycoses1
3CompletedTreatmentCandidemia / Candidiasis, Invasive1
3CompletedTreatmentCandidiasis, Invasive1
3CompletedTreatmentCoccidioidomycosis1
3CompletedTreatmentDiabetes Mellitus (DM) / Vulvovaginal Candidiasis1
3CompletedTreatmentEsophageal Candidiasis / Human Immunodeficiency Virus (HIV) Infections1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV)1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare / Mycoses1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis, Cryptococcal1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Mycoses1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Oral Candidiasis1
3CompletedTreatmentInfection NOS / Leukemias / Malignant Lymphomas1
3CompletedTreatmentOral Candidiasis1
3CompletedTreatmentTinea Capitis1
3CompletedTreatmentVaginal Discharge1
3CompletedTreatmentVulvovaginal Candidiasis1
3CompletedTreatmentCandidiasis infection2
3Not Yet RecruitingTreatmentAntifungal Drugs in Onychomycosis1
3RecruitingTreatmentAIDS-Related Opportunistic Infections / Cryptococcal infections / Cryptococcus Neoformans1
3RecruitingTreatmentCandidemia1
3TerminatedNot AvailableCandidemia1
3TerminatedTreatmentLeishmaniasis, Cutaneous1
3Unknown StatusPreventionLiver Transplant Recipients1
4CompletedPreventionCentral Nervous System Fungal Infections / Fungaemia / Lung Diseases, Fungal / Mycoses1
4CompletedPreventionCryptococcus Neoformans / Meningitis, Cryptococcal1
4CompletedPreventionCandidiasis infection1
4CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Candidiasis infection / Oral Candidiasis1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Oral Candidiasis1
4CompletedTreatmentOropharyngeal Candidiasis1
4CompletedTreatmentVulvovaginal Candidiasis2
4CompletedTreatmentCandidiasis infection1
4RecruitingTreatmentCoccidioidomycosis1
4Unknown StatusDiagnosticPulmonary Candidiasis1
4WithdrawnTreatmentCandidiasis infection / Sepsis1
Not AvailableActive Not RecruitingNot AvailableCentral Nervous System Fungal Infections / Central Nervous System Infections / Meningitis, Cryptococcal / Meningitis, Fungal1
Not AvailableActive Not RecruitingNot AvailableSystemic Fungal Infections1
Not AvailableCompletedNot AvailableDeep Mycosis1
Not AvailableCompletedNot AvailableFungal Infection by Site1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableCandidiasis infection1
Not AvailableCompletedBasic ScienceDrug Interactions / Healthy Volunteers / Warfarin1
Not AvailableCompletedBasic ScienceHeart Diseases / Vascular Diseases1
Not AvailableCompletedPreventionBlood Diseases / Graft Versus Host Disease (GVHD) / Hematopoietic Stem Cell Transplantation (HSCT) / Leukemias / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Transplantation, Bone Marrow1
Not AvailableCompletedTreatmentCoccidioidomycosis / Human Immunodeficiency Virus (HIV) Infections / Mycoses1
Not AvailableCompletedTreatmentEsophageal Candidiasis / Human Immunodeficiency Virus (HIV) Infections2
Not AvailableCompletedTreatmentCandidiasis infection / Esophageal Candidiasis / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHistoplasmosis / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis, Cryptococcal13
Not AvailableCompletedTreatmentCandidiasis infection / Human Immunodeficiency Virus (HIV) Infections / Mycoses1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Oral Candidiasis2
Not AvailableRecruitingScreeningMeningitis, Cryptococcal1
Not AvailableUnknown StatusTreatmentAutism Spectrum Conditions/Disorders1

Pharmacoeconomics

Manufacturers
  • Pfizer chemicals div pfizer inc
  • Aurobindo pharma usa inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Ranbaxy laboratories ltd
  • Roxane laboratories inc
  • Taro pharmaceutical industries ltd
  • Pfizer inc
  • Acs dobfar info sa
  • Apotex inc richmond hill
  • Hospira inc
  • App pharmaceuticals llc
  • Bedford laboratories div ben venue laboratories inc
  • Claris lifesciences ltd
  • Hikma farmaceutica portugal lda
  • Teva parenteral medicines inc
  • Baxter healthcare corp
  • Bedford laboratories
  • Pfizer central research
  • Apotex inc
  • Aurobindo pharma ltd
  • Dr reddys laboratories inc
  • Gedeon richter usa inc
  • Genpharm inc
  • Glenmark generics ltd
  • Mylan pharmaceuticals inc
  • Pliva inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Unique pharmaceutical laboratories
Packagers
Dosage forms
FormRouteStrength
TabletOral200 mg
Capsule; creamOral; Topical; Vaginal
CapsuleOral150 mg
Powder, for solutionOral50 mg
InjectionIntravenous2 mg/mL
Injection, solutionIntravenous2 mg/mL
Injection, solutionIntravenous200 mg/100mL
Injection, solutionIntravenous400 mg/200mL
Powder, for suspensionOral10 mg/mL
Powder, for suspensionOral1400 mg/35mL
Powder, for suspensionOral350 mg/35mL
Powder, for suspensionOral40 mg/mL
TabletOral100 mg/1
TabletOral150 mg/1
TabletOral200 mg/1
TabletOral50 mg/1
SolutionIntravenous2 mg
Capsule; cream; kitOral; Topical
TabletOral100 mg
TabletOral50 mg
TabletOral150 mg
Prices
Unit descriptionCostUnit
Diflucan 40 mg/ml Suspension 35ml Bottle203.65USD bottle
Fluconazole 40 mg/ml Suspension 35ml Bottle135.99USD bottle
Diflucan 10 mg/ml Suspension 35ml Bottle56.06USD bottle
Fluconazole 10 mg/ml Suspension 35ml Bottle35.94USD bottle
Diflucan 150 mg tablet24.71USD tablet
Diflucan 200 mg tablet20.82USD tablet
Diflucan 150 mg Capsule16.44USD capsule
Fluconazole 200 mg tablet14.26USD tablet
Fluconazole powder14.08USD g
Fluconazole 150 mg tablet13.93USD tablet
Diflucan 100 mg tablet12.61USD tablet
Apo-Fluconazole-150 150 mg Capsule9.18USD capsule
Co Fluconazole 150 mg Capsule9.18USD capsule
Mylan-Fluconazole 150 mg Capsule9.18USD capsule
Pms-Fluconazole 150 mg Capsule9.18USD capsule
Fluconazole 100 mg tablet8.95USD tablet
Diflucan 50 mg tablet8.05USD tablet
Apo-Fluconazole 100 mg Tablet5.81USD tablet
Mylan-Fluconazole 100 mg Tablet5.81USD tablet
Fluconazole 50 mg tablet5.7USD tablet
Co Fluconazole 100 mg Tablet5.42USD tablet
Novo-Fluconazole 100 mg Tablet5.42USD tablet
Pms-Fluconazole 100 mg Tablet5.42USD tablet
Apo-Fluconazole 50 mg Tablet3.28USD tablet
Mylan-Fluconazole 50 mg Tablet3.28USD tablet
Co Fluconazole 50 mg Tablet3.06USD tablet
Novo-Fluconazole 50 mg Tablet3.06USD tablet
Pms-Fluconazole 50 mg Tablet3.06USD tablet
Diflucan-dextr 200 mg/100 ml1.28USD ml
Diflucan-saline 200 mg/100 ml1.28USD ml
Diflucan 2 mg/ml0.6USD ml
Fluconazole 2 mg/ml0.33USD ml
Fluconazole Omega 2 mg/ml0.33USD ml
Fluconazole-dext 200 mg/100 ml0.32USD ml
Fluconazole-ns 200 mg/100 ml0.19USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)138-140 °CNot Available
water solubility1 mg/LNot Available
logP0.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.39 mg/mLALOGPS
logP0.58ALOGPS
logP0.56ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)12.71ChemAxon
pKa (Strongest Basic)2.56ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area81.65 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity97.2 m3·mol-1ChemAxon
Polarizability26.52 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9894
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.6008
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.9004
Renal organic cation transporterNon-inhibitor0.6461
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.565
CYP450 1A2 substrateNon-inhibitor0.6312
CYP450 2C9 inhibitorNon-inhibitor0.5497
CYP450 2D6 inhibitorNon-inhibitor0.809
CYP450 2C19 inhibitorInhibitor0.532
CYP450 3A4 inhibitorNon-inhibitor0.8196
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.524
Ames testNon AMES toxic0.548
CarcinogenicityNon-carcinogens0.7298
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4136 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8229
hERG inhibition (predictor II)Non-inhibitor0.6614
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-339ec0708a6a6299e4d1
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-ea278fc262275613a1fe
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-bbdadb624a7360b26fa3
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-00kf-6900000000-0316b801589bae74a3f9
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9100000000-d7b76913f55978a00d10
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9000000000-45cd8f87d45358745d5b
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9000000000-2f3230e2968762340fb0
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-ea0bdd0dd4905f7ca2a7
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-643df112c60eecdd6f26
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-00kf-6900000000-636d53fe2393f25b4cc4
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9100000000-2d05579f16a7ce194afb
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9000000000-bb834fc848ba7398b278
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-9000000000-e3f46745a82b72dc28b0
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0006-0900000000-565636d9f9e684b11429
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0006-0900000000-224c620bb2943c3558aa
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0090000000-d00a2d66aa1d04145279
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0019000000-9ddd55ba2decdc6d3007
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0079-0091000000-5501d6ab39e3fb2e3676
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00y0-1690000000-fb006053901bf08be9c9
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00y0-1920000000-a0f9f745307937304b45
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00g0-1900000000-f3d3042120b194b579d4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00bi-1900000000-8d82f395b99e530cb46e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0019000000-cf2933c2544adb816b0b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0079-0091000000-066891bc3d77fcb69c5d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00y0-1590000000-5d278aae398bb4d6c6b6
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00y0-1920000000-3dcfbc3d71451cc9331c
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00g0-1900000000-c4af46372e623cdeb3dd
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0fi9-1900000000-c15061f8dd5425cdede4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0090000000-af8c5257ccffbdd94e82
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4r-0696000000-6b076061ba56c532c132
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0abi-2795000000-c36fbab24191f149ce46
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0g70-2920000000-a8a6188f5a32495c6efa
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-05g0-1795000000-7cf5f5c74fd37b2b188f
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00dr-0390000000-5ae132600e3f7f3b30a1

Taxonomy

Description
This compound belongs to the class of organic compounds known as fluorobenzenes. These are compounds containing one or more fluorine atoms attached to a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Halobenzenes
Direct Parent
Fluorobenzenes
Alternative Parents
Aryl fluorides / Triazoles / Tertiary alcohols / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organofluorides / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Fluorobenzene / Aryl fluoride / Aryl halide / Azole / Tertiary alcohol / 1,2,4-triazole / Heteroaromatic compound / Organoheterocyclic compound / Azacycle / Aromatic alcohol
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
tertiary alcohol, triazole antifungal drug, conazole antifungal drug, difluorobenzene (CHEBI:46081)

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
Yes
Actions
Inhibitor
General Function
Sterol 14-demethylase activity
Specific Function
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name
ERG11
Uniprot ID
P10613
Uniprot Name
Lanosterol 14-alpha demethylase
Molecular Weight
60674.965 Da
References
  1. Bellamine A, Lepesheva GI, Waterman MR: Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology. J Lipid Res. 2004 Nov;45(11):2000-7. Epub 2004 Aug 16. [PubMed:15314102]
  2. Guinea J, Sanchez-Somolinos M, Cuevas O, Pelaez T, Bouza E: Fluconazole resistance mechanisms in Candida krusei: the contribution of efflux-pumps. Med Mycol. 2006 Sep;44(6):575-8. [PubMed:16966178]
  3. Chau AS, Chen G, McNicholas PM, Mann PA: Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae. Antimicrob Agents Chemother. 2006 Nov;50(11):3917-9. Epub 2006 Sep 11. [PubMed:16966400]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567]
  2. Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. [PubMed:8801056]
  3. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567]
  2. Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. [PubMed:8801056]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. [PubMed:11751127]
  2. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113]
  3. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267]

Drug created on June 13, 2005 07:24 / Updated on November 19, 2017 20:33