Did you mean sulfonylureas?
Displaying drugs 1 - 25 of 30 in total
Glyburide
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Description: … Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Glipizide
Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice...
Approved
Investigational
Matched Description: … Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used ... According to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered ... [A179488] Compared to other members of the sulfonylurea drug group, glipizide displays rapid absorption …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Gliclazide
Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release...
Approved
Matched Description: … Sulfonylureas are associated with weight gain, though less so than insulin. ... [T238, T360] Gliclazide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating ... drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Mezlocillin
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
Approved
Investigational
Metformin
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173]
Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin...
Approved
Matched Categories: … metformin and sulfonylureas …
Troglitazone
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Acetohexamide
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Approved
Investigational
Withdrawn
Matched Description: … A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Tolazamide
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Approved
Investigational
Matched Categories: … Sulfonylureas …
Torasemide
Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993.
Approved
Matched Description: … [A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. …
Glimepiride
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class ... Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Chlorpropamide
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class...
Approved
Investigational
Matched Description: … It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the ... Sulfonylureas are associated with weight gain, though less so than insulin. ... Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Tolbutamide
Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Description: … It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea ... Sulfonylureas are associated with weight gain, though less so than insulin. ... Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Gliquidone
Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Approved
Investigational
Matched Description: … Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Repaglinide
Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood...
Approved
Investigational
Matched Description: … The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas ... Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas ... of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas …
Vildagliptin
Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP),...
Approved
Investigational
Matched Description: … treatment of type II diabetes mellitus in adults as monotherapy or in combination with [metformin], a sulfonylurea …
Nicorandil
Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium...
Approved
Investigational
Nateglinide
Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin...
Approved
Investigational
Matched Description: … The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas ... Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas ... of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas …
Diazoxide
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release....
Approved
Glibornuride
Glibornuride is a sulfonylurea-type anti-diabetic drug.
Investigational
Withdrawn
Matched Description: … Glibornuride is a sulfonylurea-type anti-diabetic drug. …
Matched Categories: … Sulfonylureas …
Matched Categories: … Sulfonylureas …
Glisoxepide
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Matched Categories: … Sulfonylureas …
Grapiprant
Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class...
Investigational
Vet approved
Tribenuron Methyl
Experimental
Genistein
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.
Additionally, genistein has antihelmintic activity. It has been...
Investigational
Laromustine
VNP40101M is a novel alkylating agent that has been used in trials studying the treatment of Leukemia, Lymphoma, Lung Cancer, Small Intestine Cancer, and Myelodysplastic Syndromes, among others.
Investigational
Displaying drugs 1 - 25 of 30 in total