Carbonyl reductase [NADPH] 1
Details
- Name
- Carbonyl reductase [NADPH] 1
- Synonyms
- 1.1.1.184
- 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
- CBR
- CRN
- NADPH-dependent carbonyl reductase 1
- Prostaglandin 9-ketoreductase
- Prostaglandin-E(2) 9-reductase
- SDR21C1
- Short chain dehydrogenase/reductase family 21C member 1
- Gene Name
- CBR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006005|Carbonyl reductase [NADPH] 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
- Number of residues
- 277
- Molecular Weight
- 30374.73
- Theoretical pI
- 8.49
- GO Classification
- Functions15-hydroxyprostaglandin dehydrogenase (NADP+) activity / carbonyl reductase (NADPH) activity / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor / prostaglandin-E2 9-reductase activityProcessesarachidonic acid metabolic process / cyclooxygenase pathway / drug metabolic process / epithelial cell differentiation / oxidation-reduction process / small molecule metabolic process / vitamin K metabolic processComponentscytosol / extracellular exosome / extracellular vesicle
- General Function
- Prostaglandin-e2 9-reductase activity
- Specific Function
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012150|Carbonyl reductase [NADPH] 1 (CBR1) ATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCC ATCGTGCGCGACCTGTGCCGGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTG ACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCCCGCGCTTCCAC CAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAG TACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGTTGCTGATCCC ACACCCTTTCATATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGAT GTGTGCACAGAATTACTCCCTCTAATAAAACCCCAAGCATCCTGCGTACTGTCTGCATGG TCATGCCTCTCCCAAAATCCTTCAGGAGGAAAGTCCAAGCCCTTAGCATGGTTCACAGAG ATGTCCATAATCTGCCGCTGCTTAACTCTGGGCCCATTTTAA
- Chromosome Location
- 21
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P16152 UniProtKB Entry Name CBR1_HUMAN GenBank Gene ID J04056 GenAtlas ID CBR1 HGNC ID HGNC:1548 - General References
- Wermuth B, Bohren KM, Heinemann G, von Wartburg JP, Gabbay KH: Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. J Biol Chem. 1988 Nov 5;263(31):16185-8. [Article]
- Forrest GL, Akman S, Krutzik S, Paxton RJ, Sparkes RS, Doroshow J, Felsted RL, Glover CJ, Mohandas T, Bachur NR: Induction of a human carbonyl reductase gene located on chromosome 21. Biochim Biophys Acta. 1990 Apr 6;1048(2-3):149-55. [Article]
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- Gonzalez-Covarrubias V, Kalabus JL, Blanco JG: Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). Pharm Res. 2008 Jul;25(7):1730-4. doi: 10.1007/s11095-008-9592-5. Epub 2008 May 1. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03394 Heptaethylene glycol experimental unknown Details DB03556 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 experimental unknown Details DB04463 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol experimental unknown ligand Details DB01046 Lubiprostone approved, investigational unknown substrate Details DB00414 Acetohexamide approved, investigational, withdrawn unknown substrate Details DB04463 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol experimental unknown binder Details DB00502 Haloperidol approved unknown substrate Details DB05197 Sofalcone investigational unknown inhibitor Details DB04844 Tetrabenazine approved, investigational unknown substrate Details DB00997 Doxorubicin approved, investigational no substrate Details DB12161 Deutetrabenazine approved, investigational unknown substrate Details DB01698 Rutin approved, experimental, investigational unknown Details DB02709 Resveratrol investigational unknown inhibitor Details DB11672 Curcumin approved, investigational unknown Details DB04216 Quercetin experimental, investigational unknown Details DB06263 Amrubicin investigational unknown substrate Details DB14635 Curcumin sulfate experimental unknown Details DB01039 Fenofibrate approved unknown substrate Details DB00776 Oxcarbazepine approved unknown substrate Details DB09212 Loxoprofen approved no substrate Details DB00694 Daunorubicin approved unknown substrate Details