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Identification
NameFluconazole
Accession NumberDB00196  (APRD00327)
TypeSmall Molecule
GroupsApproved
Description

Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem]

Structure
Thumb
Synonyms
2-(2,4-DIFLUOROPHENYL)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol
2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
Biozole
Diflucan
Elazor
Fluconazol
Fluconazolum
Triflucan
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Fluconazoletablet50 mgoralActavis Pharma Company2007-12-03Not applicableCanada
Act Fluconazoletablet100 mgoralActavis Pharma Company2007-12-03Not applicableCanada
Diflucantablet50 mg/1oralRoerig1990-01-29Not applicableUs
Diflucantablet100 mg/1oralREMEDYREPACK INC.2013-02-19Not applicableUs
Diflucantablet200 mg/1oralPd Rx Pharmaceuticals, Inc.1990-01-29Not applicableUs
Diflucantablet150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1990-01-29Not applicableUs
Diflucantablet150 mg/1oralRoerig1990-01-29Not applicableUs
Diflucanpowder, for suspension1400 mg/35mLoralRoerig1993-12-23Not applicableUs
Diflucanpowder, for suspension350 mg/35mLoralRoerig1993-12-23Not applicableUs
Diflucantablet200 mg/1oralRoerig1990-01-29Not applicableUs
Diflucantablet100 mg/1oralRoerig1990-01-29Not applicableUs
Diflucantablet150 mg/1oralA S Medication Solutions1990-01-29Not applicableUs
Diflucan Inj 2mg/mlsolution2 mgintravenousPfizer Canada Inc1990-12-31Not applicableCanada
Diflucan Pws 50mg/5mlpowder for solution50 mgoralPfizer Canada Inc1995-12-31Not applicableCanada
Diflucan Tab 100mgtablet100 mgoralPfizer Canada Inc1990-12-31Not applicableCanada
Diflucan Tab 50mgtablet50 mgoralPfizer Canada Inc1990-12-31Not applicableCanada
Dom-fluconazoletablet100 mgoralDominion Pharmacal2002-07-09Not applicableCanada
Dom-fluconazoletablet50 mgoralDominion Pharmacal2002-07-09Not applicableCanada
Fluconazoletablet50 mg/1oralGreenstone LLC1990-01-29Not applicableUs
Fluconazoletablet200 mg/1oralClinical Solutions Wholesale1990-01-29Not applicableUs
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Fluconazoletablet100 mg/1oralClinical Solutions Wholesale1990-01-29Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralPhysicians Total Care, Inc.2010-04-27Not applicableUs
Fluconazoletablet100 mgoralSorres Pharma Inc2009-06-172014-06-20Canada
Fluconazolepowder, for suspension40 mg/mLoralGreenstone LLC1993-12-23Not applicableUs
Fluconazoletablet50 mgoralSorres Pharma Inc2009-06-172014-06-20Canada
Fluconazolepowder, for suspension10 mg/mLoralGreenstone LLC1993-12-23Not applicableUs
Fluconazoletablet100 mg/1oralPhysicians Total Care, Inc.2005-07-06Not applicableUs
Fluconazoletablet200 mg/1oralGreenstone LLC1990-01-29Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralPhysicians Total Care, Inc.2005-03-11Not applicableUs
Fluconazoletablet150 mg/1oralGreenstone LLC1990-01-29Not applicableUs
Fluconazoletablet200 mg/1oralPhysicians Total Care, Inc.2004-08-12Not applicableUs
Fluconazoletablet100 mg/1oralGreenstone LLC1990-01-29Not applicableUs
Fluconazoletablet150 mg/1oralPhysicians Total Care, Inc.2004-08-12Not applicableUs
Fluconazole Injectionsolution2 mgintravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Fluconazole Injectionsolution2 mgintravenousBaxter Corporation2005-09-01Not applicableCanada
Fluconazole Injectionsolution2 mgintravenousSandoz Canada Incorporated2004-01-16Not applicableCanada
Fluconazole Injectionsolution2 mgintravenousTeva Canada Limited2003-11-28Not applicableCanada
Fluconazole Injection Sdzsolution2 mgintravenousSandoz Canada Incorporated2012-10-18Not applicableCanada
Fluconazole Omegasolution2 mgintravenousOmega Laboratories Ltd2003-09-23Not applicableCanada
Mylan-fluconazoletablet100 mgoralMylan Pharmaceuticals Ulc2002-06-05Not applicableCanada
Mylan-fluconazoletablet50 mgoralMylan Pharmaceuticals Ulc2002-06-05Not applicableCanada
Novo-fluconazoletablet150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Novo-fluconazoletablet100 mgoralTeva Canada Limited2002-07-15Not applicableCanada
Novo-fluconazoletablet50 mgoralTeva Canada Limited2002-07-15Not applicableCanada
PHL-fluconazoletablet100 mgoralPharmel IncNot applicableNot applicableCanada
PMS-fluconazoletablet100 mgoralPharmascience Inc2002-06-05Not applicableCanada
PMS-fluconazoletablet50 mgoralPharmascience Inc2002-06-05Not applicableCanada
Pro-fluconazoletablet100 mgoralPro Doc Limitee2008-07-08Not applicableCanada
Riva-fluconazoletablet100 mgoralLaboratoire Riva Inc2005-10-07Not applicableCanada
Taro-fluconazoletablet200 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-fluconazoletablet100 mgoralTaro Pharmaceuticals Inc2004-11-17Not applicableCanada
Taro-fluconazoletablet50 mgoralTaro Pharmaceuticals Inc2004-11-17Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fluconazoletablet200 mgoralApotex IncNot applicableNot applicableCanada
Apo-fluconazoletablet100 mgoralApotex Inc1998-10-13Not applicableCanada
Apo-fluconazoletablet50 mgoralApotex Inc1998-10-13Not applicableCanada
Direct Rxtablet200 mg/1oralDIRECT RX2015-01-01Not applicableUs
Fluconazoletablet100 mg/1oralMylan Pharmaceuticals Inc.2013-02-26Not applicableUs
Fluconazoletablet100 mg/1oralBlue Point Laboratories2014-03-13Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralAurobindo Pharma Limited2009-09-18Not applicableUs
Fluconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-20Not applicableUs
Fluconazoletablet200 mg/1oralbryant ranch prepack2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralGlenmark Pharmaceuticals Inc., Usa2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralBlue Point Laboratories2014-03-13Not applicableUs
Fluconazoletablet200 mg/1oralDispensing Solutions, Inc.2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralbryant ranch prepack2004-07-29Not applicableUs
Fluconazoleinjection, solution200 mg/100mLintravenousBaxter Healthcare Corporation2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2004-07-29Not applicableUs
Fluconazoletablet100 mg/1oralREMEDYREPACK INC.2015-04-06Not applicableUs
Fluconazoleinjection2 mg/mLintravenousWest ward Pharmaceutical Corp2012-01-30Not applicableUs
Fluconazoletablet50 mg/1oralCitron Pharma LLC2008-10-07Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralRoxane Laboratories, Inc2004-07-29Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet200 mg/1oralAidarex Pharmaceuticals LLC2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralMylan Pharmaceuticals Inc.2013-02-26Not applicableUs
Fluconazoletablet100 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2004-07-29Not applicableUs
Fluconazoletablet200 mg/1oralNorth Star Rx Llc2008-10-07Not applicableUs
Fluconazoletablet100 mg/1oralAvera Mc Kennan Hospital2015-03-13Not applicableUs
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2011-04-21Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2015-02-19Not applicableUs
Fluconazoletablet150 mg/1oralNorth Star Rx Llc2008-10-07Not applicableUs
Fluconazoletablet150 mg/1oralBlenheim Pharmacal, Inc.2015-04-22Not applicableUs
Fluconazoletablet50 mg/1oralBlue Point Laboratories2014-03-13Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralAurobindo Pharma Limited2009-09-18Not applicableUs
Fluconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-18Not applicableUs
Fluconazoletablet150 mg/1oralGlenmark Pharmaceuticals Inc., Usa2006-01-25Not applicableUs
Fluconazoletablet100 mg/1oralCardinal Health2010-12-01Not applicableUs
Fluconazoletablet200 mg/1oralLucid Pharma Llc2008-10-07Not applicableUs
Fluconazoletablet150 mg/1oralProficient Rx LP2008-10-07Not applicableUs
Fluconazoleinjection, solution400 mg/200mLintravenousBaxter Healthcare Corporation2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2015-03-06Not applicableUs
Fluconazoleinjection2 mg/mLintravenousWest ward Pharmaceutical Corp2012-01-30Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoleinjection, solution2 mg/mLintravenousSagent Pharmaceuticals2009-09-01Not applicableUs
Fluconazoletablet50 mg/1oralMylan Pharmaceuticals Inc.2004-07-29Not applicableUs
Fluconazoletablet50 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2004-07-29Not applicableUs
Fluconazoletablet200 mg/1oralREMEDYREPACK INC.2010-12-08Not applicableUs
Fluconazoletablet100 mg/1oralNorth Star Rx Llc2008-10-07Not applicableUs
Fluconazoletablet200 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Fluconazoletablet150 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-18Not applicableUs
Fluconazoletablet100 mg/1oralGlenmark Pharmaceuticals Inc., Usa2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralCardinal Health2010-12-01Not applicableUs
Fluconazoletablet150 mg/1oralLucid Pharma Llc2008-10-07Not applicableUs
Fluconazoletablet150 mg/1oralProficient Rx LP2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralIVAX Pharmaceuticals, Inc.2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralClinical Solutions Wholesale2004-07-29Not applicableUs
Fluconazoleinjection2 mg/mLintravenousWest ward Pharmaceutical Corp2012-01-30Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet200 mg/1oralRebel Distributors Corp2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-07Not applicableUs
Fluconazoletablet100 mg/1oralREMEDYREPACK INC.2010-11-22Not applicableUs
Fluconazoletablet200 mg/1oralSTAT Rx USA LLC2004-07-29Not applicableUs
Fluconazoletablet200 mg/1oralBlenheim Pharmacal, Inc.2009-12-09Not applicableUs
Fluconazoletablet200 mg/1oralHarris Pharmaceutical, Inc.2010-12-27Not applicableUs
Fluconazoletablet200 mg/1oralAurobindo Pharma Limited2008-10-07Not applicableUs
Fluconazoletablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Fluconazoletablet150 mg/1oralIVAX Pharmaceuticals, Inc.2004-07-29Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralCitron Pharma LLC2009-09-18Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralTeva Pharmaceuticals USA Inc2008-09-22Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet150 mg/1oralRebel Distributors Corp2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2012-03-07Not applicableUs
Fluconazoletablet150 mg/1oralPd Rx Pharmaceuticals, Inc.2008-10-07Not applicableUs
Fluconazoletablet150 mg/1oralSTAT Rx USA LLC2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralMajor Pharmaceuticals2015-06-25Not applicableUs
Fluconazoletablet100 mg/1oralHarris Pharmaceutical, Inc.2010-12-27Not applicableUs
Fluconazoletablet150 mg/1oralAurobindo Pharma Limited2008-10-07Not applicableUs
Fluconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-27Not applicableUs
Fluconazoletablet50 mg/1oralGlenmark Pharmaceuticals Inc., Usa2006-01-25Not applicableUs
Fluconazoletablet100 mg/1oralCardinal Health2010-12-01Not applicableUs
Fluconazoletablet100 mg/1oralLucid Pharma Llc2008-10-07Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet100 mg/1oralRebel Distributors Corp2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralREMEDYREPACK INC.2012-03-05Not applicableUs
Fluconazoletablet100 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-25Not applicableUs
Fluconazoletablet200 mg/1oralPACK Pharmaceuticals, LLC2014-03-25Not applicableUs
Fluconazoletablet100 mg/1oralMajor Pharmaceuticals2015-06-25Not applicableUs
Fluconazoletablet50 mg/1oralHarris Pharmaceutical, Inc.2010-12-27Not applicableUs
Fluconazoletablet100 mg/1oralAurobindo Pharma Limited2008-10-07Not applicableUs
Fluconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-27Not applicableUs
Fluconazoletablet150 mg/1oralDispensing Solutions Inc.2004-09-23Not applicableUs
Fluconazoletablet200 mg/1oralDr. Reddy's Laboratories Limited2014-06-20Not applicableUs
Fluconazoletablet50 mg/1oralLucid Pharma Llc2008-10-07Not applicableUs
Fluconazoletablet100 mg/1oralIVAX Pharmaceuticals, Inc.2004-07-29Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralCitron Pharma LLC2009-09-18Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralTeva Pharmaceuticals USA Inc2008-09-22Not applicableUs
Fluconazoletablet100 mg/1oralPACK Pharmaceuticals, LLC2014-03-25Not applicableUs
Fluconazoleinjection, solution2 mg/mLintravenousHospira, Inc.2004-07-29Not applicableUs
Fluconazoletablet100 mg/1oralDispensing Solutions, Inc.2010-12-01Not applicableUs
Fluconazoletablet50 mg/1oralAurobindo Pharma Limited2008-10-07Not applicableUs
Fluconazoletablet200 mg/1oralPreferred Pharmaceuticals Inc.2016-01-04Not applicableUs
Fluconazoletablet200 mg/1oralAmerican Health Packaging2015-08-11Not applicableUs
Fluconazoletablet150 mg/1oralDr. Reddy's Laboratories Limited2014-06-20Not applicableUs
Fluconazolepowder, for suspension1400 mg/35mLoralTaro Pharmaceuticals U.S.A., Inc.2006-12-18Not applicableUs
Fluconazoletablet150 mg/1oralDIRECT RX2014-01-01Not applicableUs
Fluconazoletablet50 mg/1oralIVAX Pharmaceuticals, Inc.2004-07-29Not applicableUs
Fluconazoletablet200 mg/1oralCitron Pharma LLC2008-10-07Not applicableUs
Fluconazoleinjection, solution400 mg/200mLintravenousPfizer Laboratories Div Pfizer Inc2004-07-29Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet150 mg/1oralProficient Rx LP2004-07-29Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralNorth Star Rx Llc2009-09-18Not applicableUs
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2016-01-13Not applicableUs
Fluconazoletablet200 mg/1oralREMEDYREPACK INC.2011-12-28Not applicableUs
Fluconazoletablet150 mg/1oralPd Rx Pharmaceuticals, Inc.2004-07-29Not applicableUs
Fluconazoletablet50 mg/1oralPACK Pharmaceuticals, LLC2014-03-25Not applicableUs
Fluconazoleinjection, solution2 mg/mLintravenousHospira, Inc.2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralMed Vantx, Inc.2004-07-29Not applicableUs
Fluconazoletablet50 mg/1oralbryant ranch prepack2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralPreferred Pharmaceuticals Inc.2015-10-16Not applicableUs
Fluconazoletablet100 mg/1oralAmerican Health Packaging2014-11-10Not applicableUs
Fluconazoletablet100 mg/1oralDr. Reddy's Laboratories Limited2014-06-20Not applicableUs
Fluconazolepowder, for suspension350 mg/35mLoralTaro Pharmaceuticals U.S.A., Inc.2006-12-18Not applicableUs
Fluconazoletablet200 mg/1oralREMEDYREPACK INC.2015-09-17Not applicableUs
Fluconazoleinjection2 mg/mLintravenousWest ward Pharmaceutical Corp2005-08-23Not applicableUs
Fluconazoletablet150 mg/1oralCitron Pharma LLC2008-10-07Not applicableUs
Fluconazoleinjection, solution200 mg/100mLintravenousPfizer Laboratories Div Pfizer Inc2004-07-29Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2010-06-09Not applicableUs
Fluconazoletablet200 mg/1oralCardinal Health2015-08-11Not applicableUs
Fluconazolepowder, for suspension10 mg/mLoralNorth Star Rx Llc2009-09-18Not applicableUs
Fluconazoletablet100 mg/1oralPd Rx Pharmaceuticals, Inc.2008-10-07Not applicableUs
Fluconazoletablet100 mg/1oralREMEDYREPACK INC.2011-12-19Not applicableUs
Fluconazoletablet150 mg/1oralApothecary Shop Wholesale Inc.2011-07-01Not applicableUs
Fluconazoletablet150 mg/1oralApotheca Inc.2008-10-07Not applicableUs
Fluconazoletablet200 mg/1oralMylan Pharmaceuticals Inc.2013-02-26Not applicableUs
Fluconazoletablet150 mg/1oralMed Vantx, Inc.2011-12-21Not applicableUs
Fluconazoletablet100 mg/1oralbryant ranch prepack2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-13Not applicableUs
Fluconazoletablet200 mg/1oralBlue Point Laboratories2014-03-13Not applicableUs
Fluconazoletablet50 mg/1oralDr. Reddy's Laboratories Limited2014-06-20Not applicableUs
Fluconazoletablet200 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2004-07-29Not applicableUs
Fluconazoletablet200 mg/1oralREMEDYREPACK INC.2015-06-19Not applicableUs
Fluconazoleinjection2 mg/mLintravenousWest ward Pharmaceutical Corp2012-01-30Not applicableUs
Fluconazoletablet100 mg/1oralCitron Pharma LLC2008-10-07Not applicableUs
Fluconazolepowder, for suspension40 mg/mLoralRoxane Laboratories, Inc2004-07-29Not applicableUs
Fluconazoletablet150 mg/1oralAidarex Pharmaceuticals LLC2006-01-25Not applicableUs
Fluconazoletablet150 mg/1oralDIRECT RX2016-02-12Not applicableUs
Fluconazoletablet50 mg/1oralNorth Star Rx Llc2008-10-07Not applicableUs
Fluconazoletablet150 mg/1oralHarris Pharmaceutical, Inc.2010-12-272015-12-29Us
Fluconazoletablet150 mg/1oralREMEDYREPACK INC.2011-08-23Not applicableUs
Fluconazoleinjection2 mg/mLintravenousClaris Lifesciences Inc.2015-02-24Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fluconazole-150capsule150 mgoralApotex Inc2000-03-20Not applicableCanada
Canesoralcapsule150 mgoralBayer Inc Consumer Care2010-03-10Not applicableCanada
Co Fluconazole-150capsule150 mgoralCobalt Pharmaceuticals Company2009-07-21Not applicableCanada
Diflucan Onecapsule150 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1995-12-31Not applicableCanada
Dom-fluconazolecapsule150 mgoralDominion PharmacalNot applicableNot applicableCanada
Fluconazolecapsule150 mgoralPharmel IncNot applicableNot applicableCanada
Fluconazolecapsule150 mgoralSorres Pharma Inc2009-06-172014-06-20Canada
Fluconazolecapsule150 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Fluconazole 150capsule150 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Fluconazole 150capsule150 mgoralApotex Inc2011-03-25Not applicableCanada
Fluconazole-150capsule150 mgoralPharmascience Inc2014-02-10Not applicableCanada
Ipg-fluconazole-150capsule150 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-fluconazolecapsule150 mgoralJamp Pharma Corporation2015-01-08Not applicableCanada
Monicurecapsule150 mgoralInsight Pharmaceuticals LLC2012-03-05Not applicableCanada
Mylan-fluconazolecapsule150 mgoralMylan Pharmaceuticals Ulc2002-06-05Not applicableCanada
Novo-fluconazole-150capsule150 mgoralNovopharm Limited2002-08-15Not applicableCanada
Nu-fluconazole-150capsule150 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-fluconazolecapsule150 mgoralPharmel Inc2007-08-01Not applicableCanada
PMS-fluconazolecapsule150 mgoralPharmascience Inc2006-06-27Not applicableCanada
PMS-fluconazole-150capsule150 mgoralPharmascience Inc2002-11-13Not applicableCanada
Priva-fluconazolecapsule150 mgoralPharmapar Inc2015-05-12Not applicableCanada
Pro-fluconazolecapsule150 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Riva-fluconazolecapsule150 mgoralLaboratoire Riva Inc2004-07-26Not applicableCanada
Unapproved/Other Products Not Available
International Brands
NameCompany
ElazorNot Available
FlucazolNot Available
FlucostatNot Available
FlunizolNot Available
PritenzolNot Available
TricanNot Available
TriflucanNot Available
Brand mixtures
NameLabellerIngredients
Canesoral Combi-pakBayer Inc Consumer Care
Clotrimaderm-fluconazole Combi-packTaro Pharmaceuticals Inc
Clotrimazole-fluconazole Combi-packTaro Pharmaceuticals Inc
Monicure ComboInsight Pharmaceuticals LLC
SaltsNot Available
Categories
UNII8VZV102JFY
CAS number86386-73-4
WeightAverage: 306.2708
Monoisotopic: 306.104065446
Chemical FormulaC13H12F2N6O
InChI KeyInChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N
InChI
InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
IUPAC Name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
SMILES
OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropylamines
Direct ParentPhenylpropylamines
Alternative Parents
Substituents
  • Phenylpropylamine
  • Halobenzene
  • Fluorobenzene
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Tertiary alcohol
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of fungal infections.
PharmacodynamicsFluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane.
Mechanism of actionFluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Related Articles
Absorption90%
Volume of distributionNot Available
Protein binding11 to 12%
Metabolism

Hepatic

Route of eliminationIn normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug.
Half life30 hours (range 20-50 hours)
Clearance
  • 0.23 mL/min/Kg [adults]
  • 0.18 mL/min/Kg [In premature newborns within 36 hours of birth]
  • 0.22 mL/min/Kg [In premature newborns 6 days old]
  • 0.33 mL/min/Kg [In premature newborns 12 days old]
  • 0.4 mL/min/kg [9 Months-13 yearsreceiving single-oral 2 mg/kg]
  • 0.51 mL/min/Kg [9 Months-13 yearsreceiving single-oral 8 mg/kg]
  • 0.49 mL/min/Kg [5-15 yearsreceiving multiple IV 2 mg/kg]
  • 0.59 mL/min/Kg [5-15 yearsreceiving multiple IV 4 mg/kg]
  • 0.66 mL/min/Kg [5-15 yearsreceiving multiple IV 8 mg/kg]
ToxicitySymptoms of overdose include hallucinations and paranoid behavior.
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9894
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.6008
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.9004
Renal organic cation transporterNon-inhibitor0.6461
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.565
CYP450 1A2 substrateNon-inhibitor0.6312
CYP450 2C9 inhibitorNon-inhibitor0.5497
CYP450 2D6 inhibitorNon-inhibitor0.809
CYP450 2C19 inhibitorInhibitor0.532
CYP450 3A4 inhibitorNon-inhibitor0.8196
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.524
Ames testNon AMES toxic0.548
CarcinogenicityNon-carcinogens0.7298
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4136 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8229
hERG inhibition (predictor II)Non-inhibitor0.6614
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Pfizer chemicals div pfizer inc
  • Aurobindo pharma usa inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Ranbaxy laboratories ltd
  • Roxane laboratories inc
  • Taro pharmaceutical industries ltd
  • Pfizer inc
  • Acs dobfar info sa
  • Apotex inc richmond hill
  • Hospira inc
  • App pharmaceuticals llc
  • Bedford laboratories div ben venue laboratories inc
  • Claris lifesciences ltd
  • Hikma farmaceutica portugal lda
  • Teva parenteral medicines inc
  • Baxter healthcare corp
  • Bedford laboratories
  • Pfizer central research
  • Apotex inc
  • Aurobindo pharma ltd
  • Dr reddys laboratories inc
  • Gedeon richter usa inc
  • Genpharm inc
  • Glenmark generics ltd
  • Mylan pharmaceuticals inc
  • Pliva inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Unique pharmaceutical laboratories
Packagers
Dosage forms
FormRouteStrength
Tabletoral200 mg
Capsule; creamoral; topical; vaginal
Powder, for suspensionoral1400 mg/35mL
Powder, for suspensionoral350 mg/35mL
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral200 mg/1
Tabletoral50 mg/1
Solutionintravenous2 mg
Capsuleoral150 mg
Powder for solutionoral50 mg
Tabletoral100 mg
Tabletoral50 mg
Injectionintravenous2 mg/mL
Injection, solutionintravenous2 mg/mL
Injection, solutionintravenous200 mg/100mL
Injection, solutionintravenous400 mg/200mL
Powder, for suspensionoral10 mg/mL
Powder, for suspensionoral40 mg/mL
Kit; capsule; creamoral; topical
Tabletoral150 mg
Prices
Unit descriptionCostUnit
Diflucan 40 mg/ml Suspension 35ml Bottle203.65USD bottle
Fluconazole 40 mg/ml Suspension 35ml Bottle135.99USD bottle
Diflucan 10 mg/ml Suspension 35ml Bottle56.06USD bottle
Fluconazole 10 mg/ml Suspension 35ml Bottle35.94USD bottle
Diflucan 150 mg tablet24.71USD tablet
Diflucan 200 mg tablet20.82USD tablet
Diflucan 150 mg Capsule16.44USD capsule
Fluconazole 200 mg tablet14.26USD tablet
Fluconazole powder14.08USD g
Fluconazole 150 mg tablet13.93USD tablet
Diflucan 100 mg tablet12.61USD tablet
Apo-Fluconazole-150 150 mg Capsule9.18USD capsule
Co Fluconazole 150 mg Capsule9.18USD capsule
Mylan-Fluconazole 150 mg Capsule9.18USD capsule
Pms-Fluconazole 150 mg Capsule9.18USD capsule
Fluconazole 100 mg tablet8.95USD tablet
Diflucan 50 mg tablet8.05USD tablet
Apo-Fluconazole 100 mg Tablet5.81USD tablet
Mylan-Fluconazole 100 mg Tablet5.81USD tablet
Fluconazole 50 mg tablet5.7USD tablet
Co Fluconazole 100 mg Tablet5.42USD tablet
Novo-Fluconazole 100 mg Tablet5.42USD tablet
Pms-Fluconazole 100 mg Tablet5.42USD tablet
Apo-Fluconazole 50 mg Tablet3.28USD tablet
Mylan-Fluconazole 50 mg Tablet3.28USD tablet
Co Fluconazole 50 mg Tablet3.06USD tablet
Novo-Fluconazole 50 mg Tablet3.06USD tablet
Pms-Fluconazole 50 mg Tablet3.06USD tablet
Diflucan-dextr 200 mg/100 ml1.28USD ml
Diflucan-saline 200 mg/100 ml1.28USD ml
Diflucan 2 mg/ml0.6USD ml
Fluconazole 2 mg/ml0.33USD ml
Fluconazole Omega 2 mg/ml0.33USD ml
Fluconazole-dext 200 mg/100 ml0.32USD ml
Fluconazole-ns 200 mg/100 ml0.19USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point138-140 °CNot Available
water solubility1 mg/LNot Available
logP0.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.39 mg/mLALOGPS
logP0.58ALOGPS
logP0.56ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)12.71ChemAxon
pKa (Strongest Basic)2.56ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area81.65 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity97.2 m3·mol-1ChemAxon
Polarizability26.52 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US4404216
General ReferencesNot Available
External Links
ATC CodesD01AC15J01RA07J02AC01
AHFS Codes
  • 08:14.08
PDB EntriesNot Available
FDA labelDownload (16.9 KB)
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Fluconazole.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Fluconazole.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Fluconazole.
AlitretinoinThe metabolism of Alitretinoin can be decreased when combined with Fluconazole.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Fluconazole.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Fluconazole.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Fluconazole.
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Fluconazole.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fluconazole.
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Fluconazole.
AmrinoneThe serum concentration of Amrinone can be increased when it is combined with Fluconazole.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fluconazole.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Fluconazole.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fluconazole.
ArmodafinilThe metabolism of Armodafinil can be decreased when combined with Fluconazole.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Fluconazole.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fluconazole.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fluconazole.
AxitinibThe metabolism of Axitinib can be decreased when combined with Fluconazole.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Fluconazole.
BepridilThe serum concentration of Bepridil can be increased when it is combined with Fluconazole.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Fluconazole.
BortezomibThe metabolism of Bortezomib can be decreased when combined with Fluconazole.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fluconazole.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fluconazole.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fluconazole.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Fluconazole.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fluconazole.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Fluconazole.
BuspironeThe metabolism of Buspirone can be decreased when combined with Fluconazole.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Fluconazole.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Fluconazole.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Fluconazole.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Fluconazole.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fluconazole.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Fluconazole.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Fluconazole.
CeritinibThe metabolism of Ceritinib can be decreased when combined with Fluconazole.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Fluconazole.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Fluconazole.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Fluconazole.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fluconazole.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Fluconazole.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fluconazole.
CitalopramFluconazole may increase the QTc-prolonging activities of Citalopram.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Fluconazole.
ClidiniumThe metabolism of Clidinium can be decreased when combined with Fluconazole.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Fluconazole.
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Fluconazole resulting in a loss in efficacy.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Fluconazole.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fluconazole.
CocaineThe metabolism of Cocaine can be decreased when combined with Fluconazole.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fluconazole.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Fluconazole.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Fluconazole.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fluconazole.
Cyproterone acetateThe metabolism of Cyproterone acetate can be decreased when combined with Fluconazole.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Fluconazole.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Fluconazole.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Fluconazole.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Fluconazole.
DapsoneThe metabolism of Dapsone can be decreased when combined with Fluconazole.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Fluconazole.
DarunavirThe metabolism of Darunavir can be decreased when combined with Fluconazole.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Fluconazole.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Fluconazole.
DiazepamThe metabolism of Diazepam can be decreased when combined with Fluconazole.
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Fluconazole.
DidanosineDidanosine can cause a decrease in the absorption of Fluconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Fluconazole.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Fluconazole.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Fluconazole.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fluconazole.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fluconazole.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Fluconazole.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fluconazole.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fluconazole.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Fluconazole.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fluconazole.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fluconazole.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fluconazole.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Fluconazole.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Fluconazole.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Fluconazole.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Fluconazole.
ErythromycinFluconazole may increase the QTc-prolonging activities of Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Fluconazole.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Fluconazole.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Fluconazole.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Fluconazole.
EtoposideThe metabolism of Etoposide can be decreased when combined with Fluconazole.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Fluconazole.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fluconazole.
FelbamateThe metabolism of Felbamate can be decreased when combined with Fluconazole.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fluconazole.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fluconazole.
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Fluconazole.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fluconazole.
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Fluconazole.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Fluconazole.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Fluconazole.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Fluconazole.
FlutamideThe metabolism of Flutamide can be decreased when combined with Fluconazole.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Fluconazole.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Fluconazole.
FosaprepitantThe metabolism of Fosaprepitant can be decreased when combined with Fluconazole.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Fluconazole.
GabapentinThe serum concentration of Gabapentin can be increased when it is combined with Fluconazole.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Fluconazole.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Fluconazole.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Fluconazole.
GlipizideThe metabolism of Glipizide can be decreased when combined with Fluconazole.
GlyburideThe metabolism of Glyburide can be decreased when combined with Fluconazole.
GoserelinFluconazole may increase the QTc-prolonging activities of Goserelin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Fluconazole.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fluconazole.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Fluconazole.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fluconazole.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Fluconazole.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fluconazole.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Fluconazole resulting in a loss in efficacy.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fluconazole.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Fluconazole.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Fluconazole.
IsosorbideThe metabolism of Isosorbide can be decreased when combined with Fluconazole.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Fluconazole.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Fluconazole.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fluconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Fluconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fluconazole.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fluconazole.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Fluconazole.
KetamineThe metabolism of Ketamine can be decreased when combined with Fluconazole.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Fluconazole.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Fluconazole.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Fluconazole.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Fluconazole.
LeuprolideFluconazole may increase the QTc-prolonging activities of Leuprolide.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Fluconazole.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Fluconazole.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fluconazole.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Fluconazole.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fluconazole.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fluconazole.
MacitentanThe metabolism of MACITENTAN can be decreased when combined with Fluconazole.
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be increased when it is combined with Fluconazole.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Fluconazole.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Fluconazole.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Fluconazole.
MestranolThe metabolism of Mestranol can be decreased when combined with Fluconazole.
MethadoneThe metabolism of Methadone can be decreased when combined with Fluconazole.
MidazolamThe metabolism of Midazolam can be decreased when combined with Fluconazole.
MifepristoneMifepristone may increase the QTc-prolonging activities of Fluconazole.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Fluconazole.
ModafinilThe metabolism of Modafinil can be decreased when combined with Fluconazole.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fluconazole.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Fluconazole.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Fluconazole.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Fluconazole.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fluconazole.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fluconazole.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Fluconazole.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fluconazole.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fluconazole.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Fluconazole.
NorethisteroneThe metabolism of Norethindrone can be decreased when combined with Fluconazole.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fluconazole.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Fluconazole.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Fluconazole.
OxycodoneThe risk or severity of adverse effects can be increased when Fluconazole is combined with Oxycodone.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Fluconazole.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Fluconazole.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Fluconazole.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Fluconazole.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Fluconazole.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Fluconazole.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Fluconazole.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Fluconazole.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Fluconazole.
PimozideFluconazole may increase the arrhythmogenic activities of Pimozide.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Fluconazole.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Fluconazole.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Fluconazole.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fluconazole.
PrenylamineThe serum concentration of Prenylamine can be increased when it is combined with Fluconazole.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fluconazole.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Fluconazole.
QuinidineThe metabolism of Quinidine can be decreased when combined with Fluconazole.
QuinineThe metabolism of Quinine can be decreased when combined with Fluconazole.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Fluconazole.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Fluconazole.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fluconazole.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Fluconazole.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Fluconazole.
RisedronateThe serum concentration of Risedronate can be increased when it is combined with Fluconazole.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Fluconazole.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fluconazole.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fluconazole.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fluconazole.
SilodosinThe metabolism of Silodosin can be decreased when combined with Fluconazole.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fluconazole.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fluconazole.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Fluconazole.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Fluconazole.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fluconazole.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Fluconazole.
StiripentolThe metabolism of Stiripentol can be decreased when combined with Fluconazole.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Fluconazole.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Fluconazole.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Fluconazole.
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Fluconazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Fluconazole.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Fluconazole.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Fluconazole.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fluconazole.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Fluconazole.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Fluconazole.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Fluconazole.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Fluconazole.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Fluconazole.
TeniposideThe metabolism of Teniposide can be decreased when combined with Fluconazole.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Fluconazole.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Fluconazole.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Fluconazole.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Fluconazole.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Fluconazole.
TolazamideThe serum concentration of Tolazamide can be increased when it is combined with Fluconazole.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Fluconazole.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Fluconazole.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fluconazole.
TorasemideThe metabolism of Torasemide can be decreased when combined with Fluconazole.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fluconazole.
Trastuzumab emtansineThe metabolism of ado-trastuzumab emtansine can be decreased when combined with Fluconazole.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Fluconazole.
TriazolamThe metabolism of Triazolam can be decreased when combined with Fluconazole.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Fluconazole.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Fluconazole.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fluconazole.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Fluconazole.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Fluconazole.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Fluconazole.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fluconazole.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Fluconazole.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fluconazole.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Fluconazole.
VincristineThe metabolism of Vincristine can be decreased when combined with Fluconazole.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fluconazole.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Fluconazole.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fluconazole.
WarfarinThe metabolism of Warfarin can be decreased when combined with Fluconazole.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Fluconazole.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Fluconazole.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Fluconazole.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Fluconazole.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fluconazole.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Fluconazole.
Food Interactions
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Bellamine A, Lepesheva GI, Waterman MR: Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology. J Lipid Res. 2004 Nov;45(11):2000-7. Epub 2004 Aug 16. [PubMed:15314102 ]
  2. Guinea J, Sanchez-Somolinos M, Cuevas O, Pelaez T, Bouza E: Fluconazole resistance mechanisms in Candida krusei: the contribution of efflux-pumps. Med Mycol. 2006 Sep;44(6):575-8. [PubMed:16966178 ]
  3. Chau AS, Chen G, McNicholas PM, Mann PA: Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae. Antimicrob Agents Chemother. 2006 Nov;50(11):3917-9. Epub 2006 Sep 11. [PubMed:16966400 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567 ]
  2. Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. [PubMed:8801056 ]
  3. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567 ]
  2. Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. [PubMed:8801056 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. [PubMed:11751127 ]
  2. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  3. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:23