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Identification
NameFolic Acid
Accession NumberDB00158  (NUTR00025)
TypeSmall Molecule
GroupsApproved, Nutraceutical
Description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Structure
Thumb
Synonyms
Folacin
Folate
Folic acid
Folsaeure
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-Pteroyl-L-glutamic acid
PGA
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamic acid
Pteroylglutamic acid
Vitamin B9
Vitamin Bc
Vitamin M
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acide Folique 5 Tabtablet5 mgoralPro Doc Limitee1982-12-312010-07-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Euro Folic 5mgtablet5 mgoralEuro Pharm International Canada Inc2006-11-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acidtablet1 mg/1oralApace Packaging2009-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acid 0.4mgtablet0.4 mgoralLeiner Health Products Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Ctr Srt 800mcgtablet (extended-release)800 mcgBioenergy Inc.1979-12-311998-06-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Inj 5mg/ml USPliquid5 mgintramuscular; intravenous; subcutaneousLyphomed, Division Of Fujisawa Canada Inc.1993-12-311996-09-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Injectionsolution5 mgintramuscular; intravenous; subcutaneousFresenius Kabi Canada Ltd1996-08-14Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Injection USPliquid5 mgintramuscular; intravenous; subcutaneousSandoz Canada Incorporated1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 25mgtablet25 mgoralKripps Pharmacy Ltd.1975-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 5mgtablet5 mgEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 5mgtablet5 mgoralPendopharm Division Of De Pharmascience Inc1980-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 5mgtablet5 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 5mgtablet5 mgoralKripps Pharmacy Ltd.1975-12-311997-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 5mgtablet5 mgoralIcn Canada Ltd.1974-12-312005-04-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tablets 5mgtablet5 mgoralD.C. Labs Limited1969-12-312003-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folvitetablet5 mgoralOrimed Pharma CorporationNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folvite Inj 5mg/mlliquid5 mgintramuscular; intravenous; subcutaneousLederle Cyanamid Canada Inc.1951-12-312000-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folvite Tab 5mgtablet5 mgoralLederle Cyanamid Canada Inc.1951-12-311999-04-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-folic Acidtablet5 mgoralJamp Pharma Corporation2011-06-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-folacid 5mgtablet5 mgoralNovopharm Limited1967-12-312015-10-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-folictablet5 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Folic Acid Tab 5mgtablet5 mgoralApotex Inc1978-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acidtablet1 mg/1oralbryant ranch prepack2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralWest ward Pharmaceutical Corp2009-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCardinal Health2009-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralContract Pharmacy Services Pa2010-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralSt Marys Medical Park Pharmacy2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralUnit Dose Services2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCardinal Health2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAidarex Pharmaceuticals LLC2009-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCadila Pharmaceuticals Limited2014-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralMethod Pharmaceuticals, Llc2015-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAv Pak2005-07-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralQualitest1972-03-312015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralA S Medication Solutions Llc2009-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralBlu Pharmaceuticals, LLC2010-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralClinical Solutions Wholesale2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralExelan Pharmaceuticals, Inc.2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAi Ping Pharmaceutical Inc.2013-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralTYA Pharmaceuticals2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralClinical Solutions Wholesale, Llc2009-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2011-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralMc Kesson Contract Packaging2012-03-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralSunrise Pharmaceutical, Inc.2015-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralExcellium Pharmaceutical Inc.2009-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2011-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2012-04-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2013-08-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCardinal Health2011-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidinjection, solution5 mg/mLintramuscular; intravenous; subcutaneousAPP Pharmaceuticals, LLC2000-09-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2012-08-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation.2004-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralQualitest Pharmaceuticals2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCardinal Health2009-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralContract Pharmacy Services Pa2010-11-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralAmerican Health Packaging2013-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralMylan Institutional Inc.2011-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Folic Acidtablet1 mg/1oralCentral Texas Community Health Centers2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Folic Acidcapsule1 mgoralSisu Inc.1999-08-032006-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid (1mg Tablet)tablet1 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 0.4 Mg Tablettablet0.4 mgoralSwiss Herbal Remedies Ltd.1999-12-062007-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 0.4mgtablet0.4 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 0.4mg Dietary Supplementtablet0.4 mgoralGarden State Nutritionals1998-08-312000-06-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 0.8mgtablet0.8 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 1 mgtablet1 mgoralPreferred Nutrition Inc.2004-04-282005-08-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 1 Mg - Tablettablet1 mgoralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 1mgtablet1 mgoralJamieson Laboratories Ltd1994-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 1mgtablet1.0 mgoralWn Pharmaceuticals Ltd.2002-04-152006-08-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 400mcg Tabtablet.4 mgoralNatrol, Inc.1994-12-311999-08-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid 800mcg Tabtablet.8 mgoralNatrol, Inc.1994-12-312002-09-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Capsules 1mgcapsule1 mgoralFinlandia Consultants1990-12-311997-12-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 0.4mg USPtablet.4 mgoralPharmavite Llc1987-12-311999-08-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 1mgtablet1 mgoralSwiss Herbal Remedies Ltd.1986-12-312007-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tab 1mg USP Chewabletablet1 mgoralLab Gernetic Int Ltee1985-12-311997-02-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Folic Acid Tablets 0.8mgtablet0.8 mgoralRoyal Bodycare Canada Inc.1992-12-312001-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Natafoliktablet1 mgoralLe Groupe M. Vachon Inc.1996-10-302001-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
International Brands
NameCompany
AcfolCazi
FefolGlaxoSmithKline
Brand mixtures
NameLabellerIngredients
Acti-hydroxo/dibencoz 500 + Folic Acid TabActi Form Ltd.
Animi-3PBM Pharmaceuticals, Inc
Animi-3 With Vitamin DPBM Pharmaceuticals, Inc
Av-vite FbAv Kare, Inc.
Avon Nutrivance Stress FormulaAvon Canada Ulc
B Complex TabletsGolden Neo Life Diamite International, Limited
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B-50 Complex TabVita Health Products Inc
B-complex TabletsShaklee Canada Inc
B-nexaUpsher Smith Laboratories, Inc.
B-plexLand Art Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B6, B12 & Folic AcidNatural Factors Nutritional Products Ltd.
B6, B12 & Folic Acid Multi-vitamin TabletsWampole Brands
Balanced B-100 B-complex Vitamins TabPharmavite Llc
Balanced B-100 Timed ReleasePharmavite Llc
Balanced B-50 ComplexLeiner Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Bear EssentialsHealth Asure, Inc.
BiferarxMEDA Pharmaceuticals
Bio-b12Thorne Research Inc.
Bio-fenLisa & Gerry Freundl
C-B ComplexAvacare, Division Of Jeunique International Inc.
C.R.D.-forcePrairie Naturals
Calcium Folic Acid Plus D ChewableAcella Pharmaceuticals, LLC
Carbassist TabletsWyeth Consumer Healthcare Inc.
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Chela Potassium PlusNu Life Nutrition Ltd.
Chewable Children's Complete Multivitamins With Essential MineralsWn Pharmaceuticals Ltd.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Chewable Multivitamins With Extra CWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple VitaminsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multivitamins With MineralsWn Pharmaceuticals Ltd.
Children's Vitamins ChewableVita Health Products Inc
Childrens Chewable Multiple Vitamins TabPharmavite Llc
CiferexAdler Stern Pharmaceuticals, Llc
Citranatal DHAMission Pharmacal Company
Citranatal Harmony 3.0Mission Pharmacal Company
Citranatal RxMission Pharmacal Company
Complex-75Frega Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Cool BSisu Inc.
Daily Energy Brand B-complexEnzymatic Therapy (Canada) Inc.
Dermacinrx PurefolixPure Tek Corporation
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
DivistaUs Pharmaceutical Corporation
DuracholSterling Knight Pharmaceuticals,Llc
Ez-flexMetagenics, Inc.
Fabb TabletsMidlothian Laboratories
Fe Nate - TabNutrilite, A Division Of Access Business Group, Llc
Fem - ControlMetagenics, Inc.
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
FerivaAvion Pharmaceuticals, Llc
Feriva FaAvion Pharmaceuticals, Llc
FerivafaAvion Pharmaceuticals, Llc
Ferralet 90Mission Pharmacal Company
Fib-C MeltsApm Products Pty Ltd.
Floradix Formula LiqFlora Manufacturing And Distributing Ltd.
FolbicNcs Health Care Of Ky, Inc Dba Vangard Labs
FolcapsMidlothian Laboratories
Folcaps Care OneMidlothian Laboratories
Folcaps Omega-3Midlothian Laboratories
Folic Acid & Vitamin CHolista Health (Canada) Inc.
Folic Acid 1mg With C 20mgGahler Enterprises Ltd.
Folic Acid 1mg With Vitamin CWn Pharmaceuticals Ltd.
Folic Acid PlusVita Health Products Inc
Folic Acid With Vitamin B12 and Vitamin CFlora Manufacturing And Distributing Ltd.
Folic Acid-b12 TabStandard Process Inc.
Foltabs 800Midlothian Laboratories
FoltratePoly Pharmaceuticals, Inc.
For Kids Only Chewable MultivitaminsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Formula Ch. Les.Abundance Marketing Ltd.
Formula CnBalance Plus, Inc.
Formula D.S.Golden Pride International
Formula L.G.I.Metagenics, Inc.
Hematogen FaNnodum Pharmaceuticals
Hematogen ForteNnodum Pharmaceuticals
Hemenatal ObWh Nutritionals, Llc
HemetabWh Nutritionals, Llc
Hi Potency Balanced B-100 Complex - TabLeiner Health Products Inc.
Hill.viteHillestad Pharmaceuticals Usa
Homosistrol CapsulesMacromed Pharmicia Inc.
Homosistrox CapsulesS.A.F. Nutritional Products Inc.
Iferex 150 ForteNnodum Pharmaceuticals
Integra FUs Pharmaceutical Corporation
Integra PlusUs Pharmaceutical Corporation
Iron Vitamins B6,b12,c,folic Acid TabLaboratoire Lalco Inc.
Iron With Vitamins TabEnrich International
Isotonix Advanced B-complex Vitamins With Potassium and MagnesiumMarket America, Inc.
Isotonix Vitamin B-folic Acid-mineral SuppleMarket America, Inc.
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kid's Choice Children's Chewable Vitamins - TabVita Health Products Inc
Kids Stuff TabletsVita Health Products Inc
Kids Stuff With Iron TabletsVita Health Products Inc
Kimchi Vitamin Chewable MultivitaminTobico
Leritone AntistressInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Mag-A-folic TabMetagenics, Inc.
Magnebind 400 RxNephro Tech, Inc.
MaxfePronova Corporation
Methyl-plexThorne Research Inc.
Mnps Formula SupplementGarden State Nutritionals
Multi #2W 7 Clay Inc.
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi-vitamin With FluorideGolden State Medical Supply, Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins for Infusion LiqDavid Bull Laboratories (Pty) Ltd.
MultivitaminLaboratoires Confab Inc
Multivitamines Plus C Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Plus Fer Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamins for ChildrenQuest Vitamins A Div Of Purity Life Health Products
MvcSancilio & Company Inc
Mvc-fluorideSancilio & Company Inc.
Myferon 150 ForteMartin Ekwealor Pharmaceuticals, Inc.
Mynephrocaps Dialysis/stress Vitamin SupplementMartin Ekwealor Pharmaceuticals, Inc.
Nata KompleteWh Nutritionals, Llc
Natelle OneMEDA Pharmaceuticals
NephrocapsCardinal Health
Nexa PlusUpsher Smith Laboratories, Inc.
Nexa Select Rx Prenatal Vitamin With Plant-based DHAUpsher Smith Laboratories, Inc.
Niaacinamide Azelaic Ac Turmer Fa B6 Zinc Ox CopperVirtus Pharmaceuticals LLC
NicomideAvion Pharmaceuticals, Llc
Nioxin Recharging ComplexNioxin Research Laboratories, Inc.
Niron KompleteWh Nutritionals, Llc
Nutrol-B-complexRolmex International Inc.
O-cal Prenatal VitaminPharmics, Inc.
OcuvelAdler Stern Pharmaceuticals, Llc
Ortho DSolubiomix
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical LLC
PreferaobMEDA Pharmaceuticals
Preferaob Plus DHAAlaven Pharmaceutical LLC
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenatal Vitamins Plusbryant ranch prepack
Prenate AmAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
Purevit Dualfe PlusPure Tek Corporation
Reaphirm Plant Source DHAEverett Laboratories, Inc.
ReebokClearly Canadian Beverage Corporation
Reliv So Sense Daily Vitamin SupplementReliv International Inc.
Reno CapsNnodum Pharmaceuticals
ReplaviteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
RogenicEnzymatic Therapy (Canada) Inc.
Se-tan DHASeton Pharmaceuticals
Se-tan PlusSeton Pharmaceuticals
Shen Min Vitamin and Mineral SupplementBiotech Corporation
Stress B Complex With C, E & IronPharmavite Llc
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula Multivitamin Tablets USPLeiner Health Products Inc.
Stress Formula TabNature's Sunshine Products Of Canada Ltd.
Stress Tab With Iron and Vitamin EVita Health Products Inc
Stress Tab With Zinc, Copper and Vitamin EVita Health Products Inc
Stressease Plus Vitamins and MineralsJamieson Laboratories Ltd
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Super B12 + Folic AcidSeroyal International Inc.
Super PantoplexNu Life Nutrition Ltd.
Supplement De Vitamines Et MinerauxLand Art Inc.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
SveetsSensible Delights Specialty Foods
T.R.I. B-plex SrcAnabolic Laboratories Inc.
Tandem - FUs Pharmaceutical Corporation
Tandem DHAUs Pharmaceutical Corporation
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Tar-endNature's Sunshine Products Inc.
TozalFocus Laboratories, Inc.
TriconNnodum Pharmaceuticals
V-natalVirtus Pharmaceuticals
Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Virt-bal DHA PlusVirtus Pharmaceuticals
Virt-capsVirtus Pharmaceuticals LLC
Virt-PN PlusVirtus Pharmaceuticals LLC
Virt-viteVirtus Pharmaceuticals LLC
Virt-vite PlusVirtus Pharmaceuticals LLC
Vita-B-75 CapLes Laboratoires Vachon Inc.
Vita-folic-B CapsLes Laboratoires Vachon Inc.
Vitabanks Vitamin TabVitabank Inc.
Vitafol CapletEverett Laboratories, Inc.
Vitafol NanoEverett Laboratories, Inc.
Vitafol Ob CapletEverett Laboratories, Inc.
Vitafol OneEverett Laboratories, Inc.
Vitafol PlusEverett Laboratories, Inc.
Vitamin B Complex TabNutristar Health Products (1987) Inc.
Vitamin B Compound TabNutrilite, A Division Of Access Business Group, Llc
Vitamin B-12 With Folic Acid TabletsGeneral Nutrition Canada Inc.
Vitamin B12 Plus Tablets W Folic AcidNu Life Nutrition Ltd.
Vitamin B12-folic AcidSeroyal International Inc.
Vitamin B6 & B12 With Folic AcidWn Pharmaceuticals Ltd.
Vitogen B Stress C Vit E Zinc & CopStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vp-ggr-B6Virtus Pharmaceuticals
Vp-heme ObVirtus Pharmaceuticals LLC
Vp-heme OneVirtus Pharmaceuticals LLC
Vp-zelVirtus Pharmaceuticals
ZavaraMisemer Pharmaceuticals, Inc.
ZingiberPru Gen, Inc. Pharmaceuticals
SaltsNot Available
Categories
UNII935E97BOY8
CAS number59-30-3
WeightAverage: 441.3975
Monoisotopic: 441.139681375
Chemical FormulaC19H19N7O6
InChI KeyInChIKey=OVBPIULPVIDEAO-LBPRGKRZSA-N
InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
IUPAC Name
(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
SMILES
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as folic acids. These are heterocyclic compounds based on the 4-[(pteridin-6-ylmethyl)amino]benzoic acid skeleton conjugated with one or more L-glutamate units.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassPterins and derivatives
Direct ParentFolic acids
Alternative Parents
Substituents
  • Folic acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Hippuric acid
  • Hippuric acid or derivatives
  • Aminobenzoic acid or derivatives
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Benzoic acid or derivatives
  • Benzamide
  • Aminobenzamide
  • Phenylalkylamine
  • Substituted aniline
  • Benzoyl
  • Hydroxypyrimidine
  • Aralkylamine
  • Secondary aliphatic/aromatic amine
  • Aniline
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • Pyrimidine
  • Pyrazine
  • Primary aromatic amine
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Secondary amine
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
PharmacodynamicsFolic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Mechanism of actionFolic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingVery high to plasma protein
Metabolism

Hepatic

Route of eliminationFolic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.
Half lifeNot Available
ClearanceNot Available
ToxicityIPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7956
Blood Brain Barrier+0.7609
Caco-2 permeable-0.844
P-glycoprotein substrateSubstrate0.687
P-glycoprotein inhibitor INon-inhibitor0.9795
P-glycoprotein inhibitor IINon-inhibitor0.9969
Renal organic cation transporterNon-inhibitor0.876
CYP450 2C9 substrateNon-substrate0.8276
CYP450 2D6 substrateNon-substrate0.7947
CYP450 3A4 substrateNon-substrate0.6212
CYP450 1A2 substrateNon-inhibitor0.9281
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9435
CYP450 2C19 inhibitorNon-inhibitor0.916
CYP450 3A4 inhibitorNon-inhibitor0.9075
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.974
Ames testNon AMES toxic0.8724
CarcinogenicityNon-carcinogens0.9521
BiodegradationNot ready biodegradable0.9191
Rat acute toxicity2.4490 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9529
hERG inhibition (predictor II)Non-inhibitor0.8444
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • App pharmaceuticals llc
  • Ben venue laboratories inc
  • Wyeth pharmaceuticals inc
  • Barr laboratories inc
  • Cadista pharmaceuticals inc
  • Contract pharmacal corp
  • Everylife
  • Excellium pharmaceutical inc
  • Halsey drug co inc
  • Impax laboratories inc
  • Invagen pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lannett co inc
  • Eli lilly and co
  • Mk laboratories inc
  • Mutual pharmaceutical co inc
  • Nexgen pharma inc
  • Pharmax group inc
  • Pharmeral inc
  • Pioneer pharmaceuticals inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Tablicaps inc
  • Udl laboratories inc
  • Usl pharma inc
  • Valeant pharmaceuticals international
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals llc
  • Vintage pharmaceuticals inc
  • Watson laboratories
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
  • Mission pharmacal co
Packagers
Dosage forms
FormRouteStrength
Tabletoral5 mg
Solutionoral
Tabletoral
Waferoral
Tablet, film coatedoral
Liquidoral
Injection, solutionintramuscular; intravenous; subcutaneous5 mg/mL
Tabletoral1 mg/1
Tabletoral0.4 mg
Tabletoral1 mg
Tabletoral1.0 mg
Tabletoral.4 mg
Tabletoral.8 mg
Capsuleoral1 mg
Tablet (extended-release)800 mcg
Solutionintramuscular; intravenous; subcutaneous5 mg
Liquidintramuscular; intravenous; subcutaneous5 mg
Tabletoral25 mg
Tablet5 mg
Tabletoral0.8 mg
Powderoral
Tablet (effervescent)oral
Liquidintravenous
Tablet, chewableoral
Capsule, gelatin coatedoral
Capsuleoral
Tablet, coatedoral
Powder for solutionoral
Lozengeoral
Capsule (sustained-release)oral
Kit
Tablet
Capsule, liquid filledoral
Prices
Unit descriptionCostUnit
Folic acid 5 mg/ml vial2.14USD ml
Folic Acid 5 mg/ml2.04USD ml
Folic acid powder1.68USD g
Folvite 5 mg/ml vial1.38USD ml
Folic Acid 1 mg tablet0.15USD tablet
Folic acid 400 mcg tablet0.07USD tablet
Apo-Folic 5 mg Tablet0.04USD tablet
CVS Pharmacy folic acid 800 mcg tablet0.02USD tablet
Folic acid 0.4 mg tablet0.02USD tablet
Folic acid 0.8 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point250 dec °CPhysProp
water solubility1.6 mg/L (at 25 °C)MERCK INDEX (1983)
logP-2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0761 mg/mLALOGPS
logP-0.04ALOGPS
logP-0.68ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)3.37ChemAxon
pKa (Strongest Basic)2.09ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area208.99 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity111.01 m3·mol-1ChemAxon
Polarizability42.06 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0010z00000-4208ea3c2f5d9026c19fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00m0z00000-2c8ad037dc3b270765c4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00z0c00000-ebdec84cbb7fe5afbc0bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0z0fn00000-e5d91e4f2ab79d130b76View in MoNA
MSMass Spectrum (Electron Ionization)splash10-zg40000000-7cba521e870757539424View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Carroll G. Temple, Jr., Robert D. Elliott, Jerry D. Rose, John A. Montgomery, “Preparation of tetrahydrofolic acid from folic acid.” U.S. Patent US4206307, issued April, 1956.

US4206307
General References
  1. Kamen B: Folate and antifolate pharmacology. Semin Oncol. 1997 Oct;24(5 Suppl 18):S18-30-S18-39. Pubmed
  2. Fenech M, Aitken C, Rinaldi J: Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998 Jul;19(7):1163-71. Pubmed
  3. Zittoun J: [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism] Rev Prat. 1993 Jun 1;43(11):1358-63. Pubmed
  4. Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM, Johnson CL: Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988-91. Adv Data. 1994 Nov 14;(258):1-28. Pubmed
  5. Raiten DJ, Fisher KD: Assessment of folate methodology used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). J Nutr. 1995 May;125(5):1371S-1398S. Pubmed
External Links
ATC CodesB03BB01
AHFS Codes
  • 88:08.00
PDB Entries
FDA labelNot Available
MSDSDownload (73.7 KB)
Interactions
Drug Interactions
Drug
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Folic Acid.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Folic Acid.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Folic Acid.
PrimidoneThe serum concentration of Primidone can be decreased when it is combined with Folic Acid.
RaltitrexedThe therapeutic efficacy of Raltitrexed can be decreased when used in combination with Folic Acid.
SulfasalazineThe serum concentration of Folic Acid can be decreased when it is combined with Sulfasalazine.
Food InteractionsNot Available

Targets

1. Folate receptor beta

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Folate receptor beta P14207 Details

References:

  1. Dixit V, Van den Bossche J, Sherman DM, Thompson DH, Andres RP: Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug Chem. 2006 May-Jun;17(3):603-9. Pubmed
  2. Wlodarczyk BJ, Cabrera RM, Hill DS, Bozinov D, Zhu H, Finnell RH: Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos. Neurotoxicology. 2006 Jul;27(4):547-57. Epub 2006 Apr 18. Pubmed
  3. Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC: Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect. 2006 Oct;114(10):1547-52. Pubmed
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

2. Folate receptor gamma

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Folate receptor gamma P41439 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Shen F, Ross JF, Wang X, Ratnam M: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry. 1994 Feb 8;33(5):1209-15. Pubmed
  4. Shen F, Wu M, Ross JF, Miller D, Ratnam M: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry. 1995 Apr 25;34(16):5660-5. Pubmed
  5. Prasad PD, Ramamoorthy S, Moe AJ, Smith CH, Leibach FH, Ganapathy V: Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta. 1994 Aug 11;1223(1):71-5. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

Enzymes

1. Cytochrome P450 2E1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2E1 P05181 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Gamma-glutamyl hydrolase

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Gamma-glutamyl hydrolase Q92820 Details

References:

  1. Schneider E, Ryan TJ: Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10. Pubmed
  2. Eisele LE, Chave KJ, Lehning AC, Ryan TJ: Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim Biophys Acta. 2006 Sep;1764(9):1479-86. Epub 2006 Jul 12. Pubmed
  3. Chen L, Eitenmiller RR: Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8. Epub 2007 Apr 17. Pubmed

3. Methylenetetrahydrofolate reductase

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Methylenetetrahydrofolate reductase P42898 Details

References:

  1. West AA, Caudill MA: Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29. Pubmed
  2. Kim YI: Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 2009 May;5(4):523-42. Pubmed

Transporters

1. Canalicular multispecific organic anion transporter 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Canalicular multispecific organic anion transporter 2 O15438 Details

References:

  1. Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. Pubmed

2. ATP-binding cassette sub-family C member 11

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
ATP-binding cassette sub-family C member 11 Q96J66 Details

References:

  1. Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. Pubmed

3. Multidrug resistance-associated protein 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance-associated protein 4 O15439 Details

References:

  1. Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. Pubmed
  2. Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. Pubmed

4. Solute carrier family 22 member 6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 6 Q4U2R8 Details

References:

  1. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. Pubmed
  2. Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. Pubmed

5. ATP-binding cassette sub-family G member 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
ATP-binding cassette sub-family G member 2 Q9UNQ0 Details

References:

  1. Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. Pubmed

6. Proton-coupled folate transporter

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Proton-coupled folate transporter Q96NT5 Details

References:

  1. Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. Epub 2007 May 2. Pubmed
  2. Ashokkumar B, Mohammed ZM, Vaziri ND, Said HM: Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am J Clin Nutr. 2007 Jul;86(1):159-66. Pubmed

7. Mitochondrial folate transporter/carrier

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Mitochondrial folate transporter/carrier Q9H2D1 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:08