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Identification
NameMetoprolol
Accession NumberDB00264  (APRD00208)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.

Structure
Thumb
Synonyms
(RS)-Metoprolol
1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
DL-metoprolol
Metoprolol slow release
External Identifiers
  • CGP-2175
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ava-metoprololtablet100 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprololtablet50 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprolol (type L)tablet100 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprolol (type L)tablet50 mgoralAvanstra Inc2011-10-112014-08-21Canada
Betaloc Durules Tab 200 mgtablet (extended-release)200 mgoralAstrazeneca Canada Inc1980-12-312009-12-15Canada
Betaloc IV Inj 1 mg/mlsolution1 mgintravenousAstrazeneca Canada Inc1987-12-312016-05-12Canada
Betaloc Tab 100 mgtablet100 mgoralAstrazeneca Canada Inc1977-12-312009-12-15Canada
Betaloc Tab 50 mgtablet50 mgoralAstrazeneca Canada Inc1978-12-312009-12-15Canada
Co Metoprolol-L Tablets 100mgtablet100 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Co Metoprolol-L Tablets 50mgtablet50 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Dom-metoprolol-B - Tab 50mgtablet50 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-metoprolol-B Tab 100mgtablet100 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-metoprolol-Ltablet100 mgoralDominion Pharmacal1999-10-29Not applicableCanada
Dom-metoprolol-Ltablet25 mgoralDominion Pharmacal2004-05-27Not applicableCanada
Dom-metoprolol-Ltablet50 mgoralDominion Pharmacal1999-10-20Not applicableCanada
Gen-metoprolol Tablets 100mgtablet100 mgoralGenpharm Ulc1998-06-192009-08-05Canada
Gen-metoprolol Tablets 50mgtablet50 mgoralGenpharm Ulc1998-06-192009-08-05Canada
Jamp-metoprolol-Ltablet25 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Jamp-metoprolol-Ltablet50 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Jamp-metoprolol-Ltablet100 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Lopresor 100mgtablet100 mgoralNovartis Pharmaceuticals Canada Inc1977-12-31Not applicableCanada
Lopresor 50mgtablet50 mgoralNovartis Pharmaceuticals Canada Inc1977-12-31Not applicableCanada
Lopresor Inj 1.0mg/mlliquid1 mgintravenousNovartis Pharmaceuticals Canada Inc1987-12-31Not applicableCanada
Lopresor SR 100mgtablet (extended-release)100 mgoralNovartis Pharmaceuticals Canada Inc1985-12-31Not applicableCanada
Lopresor SR 200 mgtablet (extended-release)200 mgoralNovartis Pharmaceuticals Canada Inc1983-12-31Not applicableCanada
Lopressortablet100 mg/1oralValidus Pharmaceuticals LLC2014-05-05Not applicableUs
Lopressorinjection, solution5 mg/5mLintravenousNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Lopressortablet50 mg/1oralValidus Pharmaceuticals LLC2014-05-05Not applicableUs
Lopressortablet100 mg/1oralNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Lopressortablet50 mg/1oralNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Metoprololtablet100 mgoralSanis Health Inc2010-05-31Not applicableCanada
Metoprololtablet50 mgoralSanis Health Inc2010-05-31Not applicableCanada
Metoprolol - 25tablet25 mgoralPro Doc Limitee2007-10-26Not applicableCanada
Metoprolol SRtablet (extended-release)200 mgoralPro Doc Limitee2010-10-15Not applicableCanada
Metoprolol SRtablet (extended-release)100 mgoralPro Doc Limitee2010-10-15Not applicableCanada
Metoprolol Succinatetablet, extended release50 mg/1oralPar Pharmaceutical Inc.2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPar Pharmaceutical Inc.2006-11-21Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralPar Pharmaceutical Inc.2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPar Pharmaceutical Inc.2006-11-21Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralPd Rx Pharmaceuticals, Inc.2011-07-21Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-07-21Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralClinical Solutions Wholesale2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Tartrate Injection USPsolution1 mgintravenousSandoz Canada Incorporated2005-07-20Not applicableCanada
Metoprolol Tartrate Injection, USPsolution1 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Metoprolol-100 Tab 100mgtablet100 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Metoprolol-50 Tab 50mgtablet50 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Metoprolol-Ltablet50 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Metoprolol-Ltablet25 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Metoprolol-Ltablet100 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet100 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Metoprolol-Ltablet50 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet50 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Metoprolol-Ltablet25 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet25 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Metoprolol-Ltablet100 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Mylan-metoprolol (type L)tablet25 mgoralMylan Pharmaceuticals Ulc2007-11-15Not applicableCanada
Mylan-metoprolol (type L)tablet100 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Mylan-metoprolol (type L)tablet50 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Ntp-metoprololtablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-metop Tab 100mgtablet100 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-metop Tab 50mgtablet50 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-metoprololtablet50 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprololtablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprololtablet25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol (type L)tablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol (type L)tablet50 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol SRtablet (extended-release)200 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol SRtablet (extended-release)100 mgoralNu Pharm IncNot applicableNot applicableCanada
Pendo-metoprolol-Ltablet50 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-metoprolol-Ltablet25 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Penta-metoprolol Tabletstablet100 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Penta-metoprolol Tabletstablet50 mgoralPentapharm Ltd.Not applicableNot applicableCanada
PMS-metoprolol-B Tablets - 100mgtablet100 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-metoprolol-B Tablets - 50mgtablet50 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-metoprolol-Ltablet25 mgoralPharmascience Inc2004-03-19Not applicableCanada
PMS-metoprolol-Ltablet100 mgoralPharmascience Inc1998-04-16Not applicableCanada
PMS-metoprolol-Ltablet50 mgoralPharmascience Inc1998-04-16Not applicableCanada
PMS-metoprolol-L SRtablet (extended-release)200 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-metoprolol-L SRtablet (extended-release)100 mgoralPharmascience IncNot applicableNot applicableCanada
Q-metoprolol (type L)tablet100 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-metoprolol (type L)tablet50 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-metoprolol (type L)tablet25 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Riva-metoprolol Ltablet50 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Riva-metoprolol Ltablet25 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Riva-metoprolol Ltablet100 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Sandoz Metoprolol (type L)tablet100 mgoralSandoz Canada Incorporated2010-07-16Not applicableCanada
Sandoz Metoprolol (type L)tablet100 mgoralSandoz Canada Incorporated2003-08-122012-02-20Canada
Sandoz Metoprolol (type L)tablet50 mgoralSandoz Canada Incorporated2010-07-16Not applicableCanada
Sandoz Metoprolol (type L)tablet50 mgoralSandoz Canada Incorporated2003-08-122012-02-22Canada
Sandoz Metoprolol SRtablet (extended-release)200 mgoralSandoz Canada Incorporated2007-12-13Not applicableCanada
Sandoz Metoprolol SRtablet (extended-release)100 mgoralSandoz Canada Incorporated2007-12-13Not applicableCanada
Teva-metoprololtablet100 mgoralTeva Canada Limited1986-12-31Not applicableCanada
Teva-metoprololtablet100 mgoralTeva Canada Limited1989-12-31Not applicableCanada
Teva-metoprololtablet50 mgoralTeva Canada Limited1989-12-31Not applicableCanada
Teva-metoprololtablet50 mgoralTeva Canada Limited1986-12-31Not applicableCanada
Teva-metoprololtablet25 mgoralTeva Canada Limited2012-02-15Not applicableCanada
Toprol XLtablet, extended release100 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release25 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release50 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release200 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release100 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release50 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprol XLtablet, extended release50 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release100 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprol XLtablet, extended release25 mg/1oralAstra Zeneca Lp2001-03-26Not applicableUs
Toprol XLtablet, extended release200 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprol XLtablet, extended release25 mg/1oralbryant ranch prepack2001-03-26Not applicableUs
Toprol XLtablet, extended release50 mg/1oralLake Erie Medical DBA Quality Care Products LLC1992-02-01Not applicableUs
Toprolxl XLtablet, extended release100 mg/1oralREMEDYREPACK INC.2013-10-04Not applicableUs
Toprolxl XLtablet, extended release25 mg/1oralREMEDYREPACK INC.2013-10-04Not applicableUs
Toprolxl XLtablet, extended release50 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Metoprolol (type L) Tab 50mgtablet50 mgoralApotex Inc1988-12-31Not applicableCanada
Apo Metoprolol Tab 100mgtablet100 mgoralApotex Inc1984-12-31Not applicableCanada
Apo Metoprolol Tab 50mgtablet50 mgoralApotex Inc1984-12-31Not applicableCanada
Apo-metoprololtablet25 mgoralApotex Inc2002-10-08Not applicableCanada
Apo-metoprolol (type L) Tab 100mgtablet100 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-metoprolol SRtablet (extended-release)100 mgoralApotex Inc2007-07-30Not applicableCanada
Apo-metoprolol SRtablet (extended-release)200 mgoralApotex Inc2007-07-30Not applicableCanada
Metoprololinjection5 mg/5mLintravenousCardinal Health2012-09-25Not applicableUs
Metoprololinjection5 mg/5mLintravenousClaris Lifesciences Inc.2012-09-25Not applicableUs
Metoprololinjection5 mg/5mLintravenousSagent Pharmaceuticals2010-05-10Not applicableUs
Metoprololinjection, solution5 mg/5mLintravenousFresenius Kabi USA, LLC2010-10-28Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMedsource Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralAidarex Pharmaceuticals LLC2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralREMEDYREPACK INC.2013-03-082016-04-05Us
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralCardinal Health2014-05-12Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralActavis Pharma, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2013-06-172016-04-05Us
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralProficient Rx LP2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralActavis Pharma, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralbryant ranch prepack2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralAmerican Health Packaging2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralPhysicians Total Care, Inc.2007-08-03Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralCardinal Health2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralAmerican Health Packaging2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralProficient Rx LP2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralbryant ranch prepack2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralPhysicians Total Care, Inc.2008-02-06Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCardinal Health2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralProficient Rx LP2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralBlue Point Laboratories2014-01-01Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralCardinal Health2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralUnit Dose Services2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralBlue Point Laboratories2014-01-01Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralDispensing Solutions, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralREMEDYREPACK INC.2016-01-12Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2010-10-05Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMc Kesson Contract Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCardinal Health2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralUnit Dose Services2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/301oralNorthwind Pharmaceuticals2014-05-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralGolden State Medical Supply, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralREMEDYREPACK INC.2016-01-08Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-08-04Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralUnit Dose Services2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralRebel Distributors Corp2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/301oralNorthwind Pharmaceuticals2014-05-07Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralClinical Solutions Wholesale2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralGolden State Medical Supply, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-02-02Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralRebel Distributors Corp2009-08-03Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralClinical Solutions Wholesale2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralGolden State Medical Supply, Inc.2013-03-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralActavis Pharma, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralPhysicians Total Care, Inc.2007-07-31Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCarilion Materials Management2014-01-01Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralGolden State Medical Supply, Inc.2013-03-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralbryant ranch prepack2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralPhysicians Total Care, Inc.2010-01-05Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralAmerican Health Packaging2014-05-12Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinate E/rtablet, film coated, extended release50 mg/1oralDIRECT RX2015-01-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release47.5 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release90 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release190 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release23.75 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Tartatetablet100 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs
Metoprolol Tartatetablet50 mg/1oralNorthwind Pharmaceuticals2014-06-02Not applicableUs
Metoprolol Tartratetablet50 mg/1oralRebel Distributors Corp.1996-12-10Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.2010-10-08Not applicableUs
Metoprolol Tartratetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralREMEDYREPACK INC.2011-07-07Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc1995-04-06Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartratetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralRebel Distributors Corp.1996-12-10Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Metoprolol Tartratetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralGreenstone LLC2007-09-112016-03-31Us
Metoprolol Tartratetablet, film coated100 mg/1oralAmerican Health Packaging2010-07-26Not applicableUs
Metoprolol Tartratetablet50 mg/1oralTYA Pharmaceuticals1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2009-06-10Not applicableUs
Metoprolol Tartratetablet50 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralTYA Pharmaceuticals2009-03-24Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralA S Medication Solutions2007-09-11Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCardinal Health2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet, film coated50 mg/1oralA S Medication Solutions2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCardinal Health2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAidarex Pharmaceuticals LLC1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-16Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health2013-08-25Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSt Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAmerican Health Packaging2010-06-22Not applicableUs
Metoprolol Tartrateinjection5 mg/5mLintravenousGland Pharma Limited2014-10-06Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralContract Pharmacy Services Pa2009-06-10Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousCardinal Health2008-05-05Not applicableUs
Metoprolol Tartratetablet100 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralGreenstone LLC2007-09-112015-10-31Us
Metoprolol Tartratetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSTAT Rx USA LLC1994-05-27Not applicableUs
Metoprolol Tartratetablet50 mg/1oralBlenheim Pharmacal, Inc.2013-07-10Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralActavis Pharma, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-27Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMajor Pharmaceuticals2010-05-17Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCardinal Health2013-08-25Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralSun Pharmaceutical Industries, Inc.2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSt Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAmerican Health Packaging2010-06-09Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralbryant ranch prepack2009-03-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralContract Pharmacy Services Pa2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralPreferred Pharmaceuticals, Inc.2013-04-01Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousPhysicians Total Care, Inc.2006-12-11Not applicableUs
Metoprolol Tartratetablet25 mg/1oralDispensing Solutions, Inc.2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2013-07-23Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2010-01-122015-12-29Us
Metoprolol Tartratetablet, film coated100 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralActavis Pharma, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.1993-12-23Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralREMEDYREPACK INC.2014-04-24Not applicableUs
Metoprolol Tartratetablet50 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralbryant ranch prepack2009-03-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralContract Pharmacy Services Pa2011-01-25Not applicableUs
Metoprolol Tartratetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2015-01-13Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralPhysicians Total Care, Inc.2004-03-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralCardinal Health1997-07-012015-12-29Us
Metoprolol Tartratetablet, film coated50 mg/1oralUnit Dose Services2009-03-15Not applicableUs
Metoprolol Tartratetablet100 mg/1oralCardinal Health2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousAmerican Regent, Inc.2010-02-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.1993-12-23Not applicableUs
Metoprolol Tartratetablet25 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartratetablet100 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-12Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2013-04-22Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralProficient Rx LP1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMed Vantx, Inc.1995-04-06Not applicableUs
Metoprolol Tartratetablet50 mg/1oralPreferred Pharmaceuticals Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralPhysicians Total Care, Inc.1994-11-29Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCarilion Materials Management2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2010-06-09Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health1997-07-012015-12-29Us
Metoprolol Tartratetablet, film coated25 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet25 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousHospira, Inc.1998-07-06Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMylan Pharmaceuticals Inc.2004-02-23Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-19Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMylan Institutional Inc.1994-05-03Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2014-02-20Not applicableUs
Metoprolol Tartratetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPhysicians Total Care, Inc.1994-01-05Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCarilion Materials Management2007-09-11Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health2008-04-29Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health1998-07-06Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMc Kesson Contract Packaging2011-11-04Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2016-03-21Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.1994-05-27Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousHospira, Inc.1993-12-21Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousWest Ward Pharmaceuticals Corp2007-05-30Not applicableUs
Metoprolol Tartratetablet100 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet50 mg/1oralLake Erie Medical DBA Quality Care Products LLC1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousSandoz Inc2007-10-02Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health2010-02-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMylan Institutional Inc.1994-05-03Not applicableUs
Metoprolol Tartratetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2015-05-15Not applicableUs
Metoprolol Tartratetablet100 mg/1oralProficient Rx LP1997-07-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-15Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health1998-07-06Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet50 mg/1oralMc Kesson Contract Packaging2011-10-04Not applicableUs
Metoprolol Tartratetablet, film coated75 mg/1oralMylan Pharmaceuticals Inc.2016-03-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralBlenheim Pharmacal, Inc.2013-10-21Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousWest Ward Pharmaceuticals Corp2007-05-30Not applicableUs
Metoprolol Tartratetablet50 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Metoprolol Tartratetablet100 mg/1oralUnit Dose Services1997-07-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralREMEDYREPACK INC.2011-12-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet50 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-19Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralSandoz Inc1994-03-25Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMylan Institutional Inc.2004-09-20Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Metoprolol Tartratetablet50 mg/1oralProficient Rx LP2004-01-15Not applicableUs
Metoprolol Tartratetablet25 mg/1oralbryant ranch prepack2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralREMEDYREPACK INC.2016-04-08Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2013-12-20Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralTeva Pharmaceuticals USA Inc1995-04-06Not applicableUs
Metoprolol Tartratetablet25 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet100 mg/1oralLake Erie Medical DBA Quality Care Products LLC1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralUnit Dose Services2009-03-24Not applicableUs
Metoprolol Tartratetablet25 mg/1oralRebel Distributors Corp.2004-01-15Not applicableUs
Metoprolol Tartratetablet100 mg/1oralREMEDYREPACK INC.2011-11-02Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousCardinal Health2007-05-30Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSandoz Inc1994-03-25Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-05Not applicableUs
Metoprolol Tartratetablet25 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet25 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Metoprolol Tartratetablet25 mg/1oralProficient Rx LP2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-24Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2016-04-04Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet, film coated25 mg/1oralMc Kesson Contract Packaging2011-10-06Not applicableUs
Metoprolol Tartratetablet, film coated37.5 mg/1oralMylan Pharmaceuticals Inc.2016-03-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CorvitolNot Available
MinaxNot Available
SelokeenNot Available
TOPROLNot Available
Toprol-XLNot Available
TOPROLXLNot Available
Brand mixtures
NameLabellerIngredients
DutoprolAstra Zeneca Lp
HypertensololPhysician Therapeutics Llc
Lopressor HctValidus Pharmaceuticals LLC
Metoprolol Tartrate and HydrochlorothiazideMylan Pharmaceuticals Inc.
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-25 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-50 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 50 Mg-25 mgNorth Star Rx Llc
Salts
Name/CASStructureProperties
Metoprolol fumarate
119637-66-0
Thumb
  • InChI Key: BRIPGNJWPCKDQZ-WXXKFALUSA-N
  • Monoisotopic Mass: 650.377845947
  • Average Mass: 650.81
DBSALT001329
Metoprolol succinate
98418-47-4
Thumb
  • InChI Key: RGHAZVBIOOEVQX-UHFFFAOYSA-N
  • Monoisotopic Mass: 652.393496011
  • Average Mass: 652.826
DBSALT000863
Metoprolol tartrate
56392-17-7
Thumb
  • InChI Key: YGULWPYYGQCFMP-CEAXSRTFSA-N
  • Monoisotopic Mass: 684.383325251
  • Average Mass: 684.824
DBSALT000862
Categories
UNIIGEB06NHM23
CAS number51384-51-1
WeightAverage: 267.3639
Monoisotopic: 267.183443671
Chemical FormulaC15H25NO3
InChI KeyInChIKey=IUBSYMUCCVWXPE-UHFFFAOYSA-N
InChI
InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
IUPAC Name
1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol
SMILES
COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tyrosols and derivatives. These are compounds containing a hydroxyethyl group attached to the C4 carbon of a phenol group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenols and derivatives
Direct ParentTyrosols and derivatives
Alternative Parents
Substituents
  • Tyrosol derivative
  • Phenol ether
  • Alkyl aryl ether
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
PharmacodynamicsMetoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
Mechanism of actionMetoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Related Articles
AbsorptionRapid and complete, 50%
Volume of distributionNot Available
Protein binding12%
Metabolism

Primarily hepatic

SubstrateEnzymesProduct
Metoprolol
alpha-HydroxymetoprololDetails
Route of eliminationLess than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.
Half life3-7 hours
ClearanceNot Available
ToxicityLD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Metoprolol Action PathwayDrug actionSMP00302
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableC AlleleImproved response to blood pressure medication12844134
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801252 Not AvailableA AlleleImproved response to blood pressure medication12844134
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy12844134
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A alleleIncreased risk of slow heart rate (bradycardia)18784654
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9854
Blood Brain Barrier-0.8426
Caco-2 permeable+0.6895
P-glycoprotein substrateSubstrate0.7317
P-glycoprotein inhibitor INon-inhibitor0.8182
P-glycoprotein inhibitor IINon-inhibitor0.8382
Renal organic cation transporterNon-inhibitor0.8418
CYP450 2C9 substrateNon-substrate0.81
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.6527
CYP450 1A2 substrateNon-inhibitor0.7018
CYP450 2C9 inhibitorNon-inhibitor0.8691
CYP450 2D6 inhibitorNon-inhibitor0.7909
CYP450 2C19 inhibitorNon-inhibitor0.9555
CYP450 3A4 inhibitorNon-inhibitor0.9476
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9897
Ames testNon AMES toxic0.9163
CarcinogenicityNon-carcinogens0.9387
BiodegradationNot ready biodegradable0.8544
Rat acute toxicity1.9180 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8368
hERG inhibition (predictor II)Non-inhibitor0.8202
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novartis pharmaceuticals corp
  • Kv pharmaceutical co
  • Sandoz inc
  • Watson laboratories inc florida
  • Wockhardt ltd
  • Astrazeneca lp
  • Bedford laboratories
  • Hikma farmaceutica (portugal) sa
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Sagent strides llc
  • Sandoz canada inc
  • Watson laboratories inc
  • Apothecon inc div bristol myers squibb
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Ipca laboratories ltd
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Solco healthcare us llc
  • Teva pharmaceuticals usa inc
  • Teva pharmaceuticals usa
Packagers
Dosage forms
FormRouteStrength
Tabletoral25 mg
Tablet, film coatedoral
Kit
Liquidintravenous1 mg
Tablet (extended-release)oral100 mg
Tablet (extended-release)oral200 mg
Injection, solutionintravenous5 mg/5mL
Tabletoral100 mg/1
Tabletoral50 mg/1
Injectionintravenous5 mg/5mL
Tablet, film coated, extended releaseoral100 mg/1
Tablet, film coated, extended releaseoral200 mg/1
Tablet, film coated, extended releaseoral25 mg/301
Tablet, film coated, extended releaseoral25 mg/1
Tablet, film coated, extended releaseoral50 mg/1
Tablet, film coated, extended releaseoral50 mg/301
Tablet, film coated, extended releaseoral190 mg/1
Tablet, film coated, extended releaseoral23.75 mg/1
Tablet, film coated, extended releaseoral47.5 mg/1
Tablet, film coated, extended releaseoral90 mg/1
Injection, solutionintravenous1 mg/mL
Tabletoral25 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral37.5 mg/1
Tablet, film coatedoral50 mg/1
Tablet, film coatedoral75 mg/1
Tabletoral
Solutionintravenous1 mg
Tabletoral100 mg
Tabletoral50 mg
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, extended releaseoral25 mg/1
Tablet, extended releaseoral50 mg/1
Prices
Unit descriptionCostUnit
Metoprolol tartrate powder5.51USD g
Lopressor 5 mg/5 ml ampul3.85USD ml
Lopressor hct 100-25 tablet3.21USD tablet
Toprol XL 200 mg 24 Hour tablet3.08USD tablet
Lopressor HCT 100-50 mg tablet3.06USD tablet
Toprol xl 200 mg tablet2.96USD tablet
Lopressor hct 100-50 tablet2.82USD tablet
Lopressor 100 mg tablet2.75USD tablet
Metoprolol Succinate 200 mg 24 Hour tablet2.62USD tablet
Metoprolol succ er 200 mg tablet2.29USD tablet
Lopressor HCT 100-25 mg tablet2.21USD tablet
Lopressor HCT 50-25 mg tablet2.14USD tablet
Lopressor hct 50-25 tablet2.06USD tablet
Toprol XL 100 mg 24 Hour tablet1.93USD tablet
Toprol xl 100 mg tablet1.86USD tablet
Lopressor 50 mg tablet1.81USD tablet
Metoprolol Succinate 100 mg 24 Hour tablet1.53USD tablet
Metoprolol succ er 100 mg tablet1.44USD tablet
Toprol XL 25 mg 24 Hour tablet1.43USD tablet
Toprol XL 50 mg 24 Hour tablet1.43USD tablet
Lopresor 1 mg/ml1.29USD ml
Toprol xl 25 mg tablet1.24USD tablet
Toprol xl 50 mg tablet1.24USD tablet
Metoprolol Succinate 25 mg 24 Hour tablet1.17USD tablet
Metoprolol Succinate 50 mg 24 Hour tablet1.13USD tablet
Metoprolol succ er 50 mg tablet0.9USD tablet
Metoprolol succ er 25 mg tablet0.87USD tablet
Metoprolol tartrate 100 mg tablet0.8USD tablet
Toprol xl 100 mg tablet sa0.8USD tablet
Lopresor 100 mg Tablet0.61USD tablet
Lopresor Sr 200 mg Sustained-Release Tablet0.61USD tablet
Metoprolol tartrate 50 mg tablet0.56USD tablet
Metoprolol tartrate 25 mg tablet0.34USD tablet
Apo-Metoprolol Sr 200 mg Sustained-Release Tablet0.34USD tablet
Lopresor Sr 100 mg Sustained-Release Tablet0.34USD tablet
Sandoz Metoprolol Sr 200 mg Sustained-Release Tablet0.34USD tablet
Lopresor 50 mg Tablet0.3USD tablet
Apo-Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Apo-Metoprolol 100 mg Tablet0.23USD tablet
Mylan-Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Novo-Metoprol (Fc) 100 mg Tablet0.23USD tablet
Novo-Metoprol 100 mg Tablet0.23USD tablet
Nu-Metop 100 mg Tablet0.23USD tablet
Pms-Metoprolol-L 100 mg Tablet0.23USD tablet
Sandoz Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Apo-Metoprolol Sr 100 mg Sustained-Release Tablet0.19USD tablet
Sandoz Metoprolol Sr 100 mg Sustained-Release Tablet0.19USD tablet
Apo-Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Apo-Metoprolol 50 mg Tablet0.13USD tablet
Mylan-Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Novo-Metoprol (Fc) 50 mg Tablet0.13USD tablet
Novo-Metoprol 50 mg Tablet0.13USD tablet
Nu-Metop 50 mg Tablet0.13USD tablet
Pms-Metoprolol-L 50 mg Tablet0.13USD tablet
Sandoz Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Apo-Metoprolol 25 mg Tablet0.07USD tablet
Pms-Metoprolol-L 25 mg Tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point120 °C (tartarate salt)Not Available
water solubility1.69E+004 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP1.88HANSCH,C ET AL. (1995)
Caco2 permeability-4.59ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.402 mg/mLALOGPS
logP1.8ALOGPS
logP1.76ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)14.09ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area50.72 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity76.7 m3·mol-1ChemAxon
Polarizability31.9 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-0v0c-3248359000-0353ef81c3bc6d7fcfd5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-014l-2514911000-b5f7785723f1eaf61e6fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-05ir-1729351100-fb362124379cb4616c5eView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US3998790
General References
  1. Authors unspecified: Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7. [PubMed:10376614 ]
External Links
ATC CodesC07AB02C07AB52C07BB02C07BB52C07CB02C07FB02
AHFS Codes
  • 24:24.00
PDB EntriesNot Available
FDA labelDownload (439 KB)
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Metoprolol can be increased when it is combined with Abiraterone.
AcepromazineAcepromazine may increase the hypotensive activities of Metoprolol.
AcetylcholineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Acetylcholine.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Metoprolol.
AlfuzosinMetoprolol may increase the orthostatic hypotensive activities of Alfuzosin.
AmifostineMetoprolol may increase the hypotensive activities of Amifostine.
AmiodaroneThe serum concentration of Metoprolol can be increased when it is combined with Amiodarone.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Metoprolol.
BretyliumBretylium may increase the bradycardic activities of Metoprolol.
BrimonidineBrimonidine may increase the antihypertensive activities of Metoprolol.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Metoprolol.
BupropionThe serum concentration of Metoprolol can be increased when it is combined with Bupropion.
ButabarbitalThe serum concentration of Metoprolol can be decreased when it is combined with Butabarbital.
ButethalThe serum concentration of Metoprolol can be decreased when it is combined with Butethal.
CabergolineMetoprolol may increase the vasoconstricting activities of Cabergoline.
CarbacholThe risk or severity of adverse effects can be increased when Metoprolol is combined with Carbachol.
CelecoxibThe serum concentration of Metoprolol can be increased when it is combined with Celecoxib.
CeritinibMetoprolol may increase the bradycardic activities of Ceritinib.
ChloroquineThe metabolism of Metoprolol can be decreased when combined with Chloroquine.
ChlorpromazineThe serum concentration of Metoprolol can be increased when it is combined with Chlorpromazine.
ChlorpropamideMetoprolol may increase the hypoglycemic activities of Chlorpropamide.
CimetidineThe serum concentration of Metoprolol can be increased when it is combined with Cimetidine.
CinacalcetThe serum concentration of Metoprolol can be increased when it is combined with Cinacalcet.
ClobazamThe serum concentration of Metoprolol can be increased when it is combined with Clobazam.
ClomipramineThe serum concentration of Metoprolol can be increased when it is combined with Clomipramine.
ClozapineThe serum concentration of Metoprolol can be increased when it is combined with Clozapine.
CobicistatThe serum concentration of Metoprolol can be increased when it is combined with Cobicistat.
CocaineThe serum concentration of Metoprolol can be increased when it is combined with Cocaine.
DarifenacinThe serum concentration of Metoprolol can be increased when it is combined with Darifenacin.
DarunavirThe serum concentration of Metoprolol can be increased when it is combined with Darunavir.
DelavirdineThe serum concentration of Metoprolol can be increased when it is combined with Delavirdine.
DesipramineThe serum concentration of Metoprolol can be increased when it is combined with Desipramine.
DiazoxideDiazoxide may increase the hypotensive activities of Metoprolol.
DigoxinMetoprolol may increase the bradycardic activities of Digoxin.
DiphenhydramineThe serum concentration of Metoprolol can be increased when it is combined with Diphenhydramine.
DipivefrinDipivefrin may increase the atrioventricular blocking (AV block) activities of Metoprolol.
DipyridamoleDipyridamole may increase the bradycardic activities of Metoprolol.
DisopyramideDisopyramide may increase the bradycardic activities of Metoprolol.
DronedaroneDronedarone may increase the bradycardic activities of Metoprolol.
DuloxetineThe serum concentration of Metoprolol can be increased when it is combined with Duloxetine.
EliglustatThe serum concentration of Metoprolol can be increased when it is combined with Eliglustat.
EsmololEsmolol may increase the bradycardic activities of Metoprolol.
FingolimodMetoprolol may increase the bradycardic activities of Fingolimod.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Metoprolol.
FluoxetineThe serum concentration of Metoprolol can be increased when it is combined with Fluoxetine.
FluvoxamineThe serum concentration of Metoprolol can be increased when it is combined with Fluvoxamine.
HaloperidolThe serum concentration of Metoprolol can be increased when it is combined with Haloperidol.
HeptabarbitalThe serum concentration of Metoprolol can be decreased when it is combined with Heptabarbital.
HexobarbitalThe serum concentration of Metoprolol can be decreased when it is combined with Hexobarbital.
ImipramineThe serum concentration of Metoprolol can be increased when it is combined with Imipramine.
InfliximabInfliximab may decrease the antihypertensive activities of Metoprolol.
IsoniazidThe serum concentration of Metoprolol can be increased when it is combined with Isoniazid.
IvabradineMetoprolol may increase the bradycardic activities of Ivabradine.
KetoconazoleThe serum concentration of Metoprolol can be increased when it is combined with Ketoconazole.
LacosamideMetoprolol may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LercanidipineLercanidipine may increase the hypotensive activities of Metoprolol.
LevodopaMetoprolol may increase the orthostatic hypotensive activities of Levodopa.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Metoprolol.
LorcaserinThe serum concentration of Metoprolol can be increased when it is combined with Lorcaserin.
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Metoprolol.
MethacholineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Methacholine.
MethadoneThe serum concentration of Metoprolol can be increased when it is combined with Methadone.
MethohexitalThe serum concentration of Metoprolol can be decreased when it is combined with Methohexital.
MethotrimeprazineThe serum concentration of Metoprolol can be increased when it is combined with Methotrimeprazine.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Metoprolol.
MidodrineMetoprolol may increase the bradycardic activities of Midodrine.
MirabegronMirabegron may decrease the antihypertensive activities of Metoprolol.
MolsidomineMolsidomine may increase the hypotensive activities of Metoprolol.
MoxonidineMoxonidine may increase the hypotensive activities of Metoprolol.
NicardipineThe serum concentration of Metoprolol can be increased when it is combined with Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Metoprolol.
NifedipineNifedipine may increase the hypotensive activities of Metoprolol.
NilotinibThe serum concentration of Metoprolol can be increased when it is combined with Nilotinib.
ObinutuzumabMetoprolol may increase the hypotensive activities of Obinutuzumab.
OctreotideOctreotide may increase the bradycardic activities of Metoprolol.
OrciprenalineMetoprolol may decrease the activities of Orciprenaline.
PanobinostatThe serum concentration of Metoprolol can be increased when it is combined with Panobinostat.
ParoxetineThe serum concentration of Metoprolol can be increased when it is combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Metoprolol can be decreased when it is combined with Peginterferon alfa-2b.
PentobarbitalThe serum concentration of Metoprolol can be decreased when it is combined with Pentobarbital.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Metoprolol.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Metoprolol.
PrazosinMetoprolol may increase the orthostatic hypotensive activities of Prazosin.
PrimidoneThe serum concentration of Metoprolol can be decreased when it is combined with Primidone.
PromazineThe serum concentration of Metoprolol can be increased when it is combined with Promazine.
PropafenoneThe serum concentration of Metoprolol can be increased when it is combined with Propafenone.
QuinidineThe serum concentration of Metoprolol can be increased when it is combined with Quinidine.
QuinineQuinine may increase the hypotensive activities of Metoprolol.
RegorafenibRegorafenib may increase the bradycardic activities of Metoprolol.
ReserpineReserpine may increase the hypotensive activities of Metoprolol.
RisperidoneMetoprolol may increase the hypotensive activities of Risperidone.
RitonavirThe serum concentration of Metoprolol can be increased when it is combined with Ritonavir.
RituximabMetoprolol may increase the hypotensive activities of Rituximab.
RivastigmineRivastigmine may increase the bradycardic activities of Metoprolol.
RolapitantThe serum concentration of Metoprolol can be increased when it is combined with Rolapitant.
RuxolitinibRuxolitinib may increase the bradycardic activities of Metoprolol.
SecobarbitalThe serum concentration of Metoprolol can be decreased when it is combined with Secobarbital.
SertralineThe serum concentration of Metoprolol can be increased when it is combined with Sertraline.
StiripentolThe serum concentration of Metoprolol can be increased when it is combined with Stiripentol.
SufentanilSufentanil may increase the bradycardic activities of Metoprolol.
TacrineTacrine may increase the bradycardic activities of Metoprolol.
TadalafilTadalafil may increase the antihypertensive activities of Metoprolol.
TerbinafineThe serum concentration of Metoprolol can be increased when it is combined with Terbinafine.
TheophyllineMetoprolol may decrease the activities of Theophylline.
ThioridazineThe serum concentration of Metoprolol can be increased when it is combined with Thioridazine.
TiclopidineThe serum concentration of Metoprolol can be increased when it is combined with Ticlopidine.
TipranavirThe serum concentration of Metoprolol can be increased when it is combined with Tipranavir.
TofacitinibTofacitinib may increase the bradycardic activities of Metoprolol.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Metoprolol.
TreprostinilTreprostinil may increase the hypotensive activities of Metoprolol.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Metoprolol.
VardenafilVardenafil may increase the antihypertensive activities of Metoprolol.
YohimbineYohimbine may decrease the antihypertensive activities of Metoprolol.
Food Interactions
  • Avoid alcohol.
  • Avoid natural licorice.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Schafer M, Frischkopf K, Taimor G, Piper HM, Schluter KD: Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. Am J Physiol Cell Physiol. 2000 Aug;279(2):C495-503. [PubMed:10913016 ]
  2. Staudt A, Mobini R, Fu M, Grosse Y, Stangl V, Stangl K, Thiele A, Baumann G, Felix SB: beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes. Eur J Pharmacol. 2001 Jul 6;423(2-3):115-9. [PubMed:11448474 ]
  3. Staudt Y, Mobini R, Fu M, Felix SB, Kuhn JP, Staudt A: Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. Eur J Pharmacol. 2003 Apr 11;466(1-2):1-6. [PubMed:12679135 ]
  4. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [PubMed:12844134 ]
  5. Liu J, Liu ZQ, Tan ZR, Chen XP, Wang LS, Zhou G, Zhou HH: Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther. 2003 Oct;74(4):372-9. [PubMed:14534524 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Zebrack JS, Munger M, Macgregor J, Lombardi WL, Stoddard GP, Gilbert EM: Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy. 2009 Aug;29(8):883-90. doi: 10.1592/phco.29.8.883. [PubMed:19637941 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Belpaire FM, Wijnant P, Temmerman A, Rasmussen BB, Brosen K: The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. Eur J Clin Pharmacol. 1998 May;54(3):261-4. [PubMed:9681670 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. [PubMed:10960071 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. [PubMed:11895100 ]
  2. Doppenschmitt S, Langguth P, Regardh CG, Andersson TB, Hilgendorf C, Spahn-Langguth H: Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay. J Pharmacol Exp Ther. 1999 Jan;288(1):348-57. [PubMed:9862789 ]
  3. Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. [PubMed:12948010 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on May 02, 2016 21:17