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Identification
NameMetoprolol
Accession NumberDB00264  (APRD00208)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionMetoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.
Structure
Thumb
Synonyms
(RS)-Metoprolol
1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
DL-metoprolol
Metoprolol slow release
External Identifiers
  • CGP-2175
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ava-metoprololtablet50 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprololtablet100 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprolol (type L)tablet50 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-metoprolol (type L)tablet100 mgoralAvanstra Inc2011-10-112014-08-21Canada
Betaloc Durules Tab 200 mgtablet (extended-release)200 mgoralAstrazeneca Canada Inc1980-12-312009-12-15Canada
Betaloc IV Inj 1 mg/mlsolution1 mgintravenousAstrazeneca Canada Inc1987-12-312016-05-12Canada
Betaloc Tab 100 mgtablet100 mgoralAstrazeneca Canada Inc1977-12-312009-12-15Canada
Betaloc Tab 50 mgtablet50 mgoralAstrazeneca Canada Inc1978-12-312009-12-15Canada
Co Metoprolol-L Tablets 100mgtablet100 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Co Metoprolol-L Tablets 50mgtablet50 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Dom-metoprolol-B - Tab 50mgtablet50 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-metoprolol-B Tab 100mgtablet100 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-metoprolol-Ltablet50 mgoralDominion Pharmacal1999-10-20Not applicableCanada
Dom-metoprolol-Ltablet100 mgoralDominion Pharmacal1999-10-29Not applicableCanada
Dom-metoprolol-Ltablet25 mgoralDominion Pharmacal2004-05-27Not applicableCanada
Gen-metoprolol Tablets 100mgtablet100 mgoralGenpharm Ulc1998-06-192009-08-05Canada
Gen-metoprolol Tablets 50mgtablet50 mgoralGenpharm Ulc1998-06-192009-08-05Canada
Jamp-metoprolol-Ltablet25 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Jamp-metoprolol-Ltablet50 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Jamp-metoprolol-Ltablet100 mgoralJamp Pharma Corporation2010-10-21Not applicableCanada
Lopresor 100mgtablet100 mgoralNovartis Pharmaceuticals Canada Inc1977-12-31Not applicableCanada
Lopresor 50mgtablet50 mgoralNovartis Pharmaceuticals Canada Inc1977-12-31Not applicableCanada
Lopresor Inj 1.0mg/mlliquid1 mgintravenousNovartis Pharmaceuticals Canada Inc1987-12-31Not applicableCanada
Lopresor SR 100mgtablet (extended-release)100 mgoralNovartis Pharmaceuticals Canada Inc1985-12-31Not applicableCanada
Lopresor SR 200 mgtablet (extended-release)200 mgoralNovartis Pharmaceuticals Canada Inc1983-12-31Not applicableCanada
Lopressortablet50 mg/1oralValidus Pharmaceuticals LLC2014-05-05Not applicableUs
Lopressorinjection, solution5 mg/5mLintravenousNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Lopressortablet100 mg/1oralValidus Pharmaceuticals LLC2014-05-05Not applicableUs
Lopressortablet50 mg/1oralNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Lopressortablet100 mg/1oralNovartis Pharmaceuticals Corporation1978-01-15Not applicableUs
Metoprololtablet50 mgoralSanis Health Inc2010-05-31Not applicableCanada
Metoprololtablet100 mgoralSanis Health Inc2010-05-31Not applicableCanada
Metoprolol - 25tablet25 mgoralPro Doc Limitee2007-10-26Not applicableCanada
Metoprolol SRtablet (extended-release)200 mgoralPro Doc Limitee2010-10-15Not applicableCanada
Metoprolol SRtablet (extended-release)100 mgoralPro Doc Limitee2010-10-15Not applicableCanada
Metoprolol Succinatetablet, extended release25 mg/1oralPar Pharmaceutical Inc.2006-11-21Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralClinical Solutions Wholesale2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPar Pharmaceutical Inc.2006-11-21Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralPar Pharmaceutical Inc.2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralPar Pharmaceutical Inc.2007-08-02Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-07-21Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralPd Rx Pharmaceuticals, Inc.2011-07-21Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralPar Pharmaceutical Inc.2007-07-26Not applicableUs
Metoprolol Tartrate Injection USPsolution1 mgintravenousSterimax IncNot applicableNot applicableCanada
Metoprolol Tartrate Injection USPsolution1 mgintravenousSandoz Canada Incorporated2005-07-20Not applicableCanada
Metoprolol Tartrate Injection, USPsolution1 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Metoprolol-100 Tab 100mgtablet100 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Metoprolol-50 Tab 50mgtablet50 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Metoprolol-Ltablet100 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Metoprolol-Ltablet50 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet25 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Metoprolol-Ltablet100 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet25 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Metoprolol-Ltablet50 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Metoprolol-Ltablet50 mgoralMeliapharm Inc2004-07-222014-06-25Canada
Metoprolol-Ltablet25 mgoralSivem Pharmaceuticals Ulc2015-07-09Not applicableCanada
Metoprolol-Ltablet100 mgoralSorres Pharma Inc2009-02-262014-06-20Canada
Mylan-metoprolol (type L)tablet50 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Mylan-metoprolol (type L)tablet100 mgoralMylan Pharmaceuticals Ulc1995-12-31Not applicableCanada
Mylan-metoprolol (type L)tablet25 mgoralMylan Pharmaceuticals Ulc2007-11-15Not applicableCanada
Ntp-metoprololtablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-metoprololtablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-metop Tab 100mgtablet100 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-metop Tab 50mgtablet50 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-metoprololtablet50 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprololtablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprololtablet25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol (type L)tablet50 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol (type L)tablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol SRtablet (extended-release)100 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-metoprolol SRtablet (extended-release)200 mgoralNu Pharm IncNot applicableNot applicableCanada
Pendo-metoprolol-Ltablet25 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-metoprolol-Ltablet50 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Penta-metoprolol Tabletstablet100 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Penta-metoprolol Tabletstablet50 mgoralPentapharm Ltd.Not applicableNot applicableCanada
PMS-metoprolol-B Tablets - 100mgtablet100 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-metoprolol-B Tablets - 50mgtablet50 mgoralPharmascience Inc1995-12-31Not applicableCanada
PMS-metoprolol-Ltablet25 mgoralPharmascience Inc2004-03-19Not applicableCanada
PMS-metoprolol-Ltablet50 mgoralPharmascience Inc1998-04-16Not applicableCanada
PMS-metoprolol-Ltablet100 mgoralPharmascience Inc1998-04-16Not applicableCanada
PMS-metoprolol-L SRtablet (extended-release)100 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-metoprolol-L SRtablet (extended-release)200 mgoralPharmascience IncNot applicableNot applicableCanada
Q-metoprolol (type L)tablet100 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-metoprolol (type L)tablet25 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-metoprolol (type L)tablet50 mgoralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Riva-metoprolol Ltablet100 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Riva-metoprolol Ltablet25 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Riva-metoprolol Ltablet50 mgoralLaboratoire Riva Inc2008-09-10Not applicableCanada
Sandoz Metoprolol (type L)tablet50 mgoralSandoz Canada Incorporated2003-08-122012-02-22Canada
Sandoz Metoprolol (type L)tablet100 mgoralSandoz Canada Incorporated2003-08-122012-02-20Canada
Sandoz Metoprolol (type L)tablet50 mgoralSandoz Canada Incorporated2010-07-16Not applicableCanada
Sandoz Metoprolol (type L)tablet100 mgoralSandoz Canada Incorporated2010-07-16Not applicableCanada
Sandoz Metoprolol SRtablet (extended-release)100 mgoralSandoz Canada Incorporated2007-12-13Not applicableCanada
Sandoz Metoprolol SRtablet (extended-release)200 mgoralSandoz Canada Incorporated2007-12-13Not applicableCanada
Teva-metoprololtablet25 mgoralTeva Canada Limited2012-02-15Not applicableCanada
Teva-metoprololtablet50 mgoralTeva Canada Limited1986-12-31Not applicableCanada
Teva-metoprololtablet50 mgoralTeva Canada Limited1989-12-31Not applicableCanada
Teva-metoprololtablet100 mgoralTeva Canada Limited1986-12-31Not applicableCanada
Teva-metoprololtablet100 mgoralTeva Canada Limited1989-12-31Not applicableCanada
Toprol XLtablet, extended release50 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprol XLtablet, extended release50 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release50 mg/1oralLake Erie Medical DBA Quality Care Products LLC1992-02-01Not applicableUs
Toprol XLtablet, extended release50 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release25 mg/1oralbryant ranch prepack2001-03-26Not applicableUs
Toprol XLtablet, extended release100 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release25 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release200 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprol XLtablet, extended release200 mg/1oralAstra Zeneca Lp1992-02-01Not applicableUs
Toprol XLtablet, extended release100 mg/1oralCardinal Health2010-05-10Not applicableUs
Toprol XLtablet, extended release25 mg/1oralAstra Zeneca Lp2001-03-26Not applicableUs
Toprol XLtablet, extended release100 mg/1oralbryant ranch prepack1992-02-01Not applicableUs
Toprolxl XLtablet, extended release100 mg/1oralREMEDYREPACK INC.2013-10-04Not applicableUs
Toprolxl XLtablet, extended release50 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Toprolxl XLtablet, extended release25 mg/1oralREMEDYREPACK INC.2013-10-04Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Metoprolol (type L) Tab 50mgtablet50 mgoralApotex Inc1988-12-31Not applicableCanada
Apo Metoprolol Tab 100mgtablet100 mgoralApotex Inc1984-12-31Not applicableCanada
Apo Metoprolol Tab 50mgtablet50 mgoralApotex Inc1984-12-31Not applicableCanada
Apo-metoprololtablet25 mgoralApotex Inc2002-10-08Not applicableCanada
Apo-metoprolol (type L) Tab 100mgtablet100 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-metoprolol SRtablet (extended-release)200 mgoralApotex Inc2007-07-30Not applicableCanada
Apo-metoprolol SRtablet (extended-release)100 mgoralApotex Inc2007-07-30Not applicableCanada
Metoprololinjection5 mg/5mLintravenousSagent Pharmaceuticals2010-05-10Not applicableUs
Metoprololinjection5 mg/5mLintravenousClaris Lifesciences Inc.2012-09-25Not applicableUs
Metoprololinjection, solution5 mg/5mLintravenousFresenius Kabi USA, LLC2010-10-28Not applicableUs
Metoprololinjection5 mg/5mLintravenousCardinal Health2012-09-25Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2010-10-05Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralbryant ranch prepack2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralDispensing Solutions, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralUnit Dose Services2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralREMEDYREPACK INC.2016-01-08Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralPhysicians Total Care, Inc.2007-07-31Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralGolden State Medical Supply, Inc.2013-03-22Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralActavis Pharma, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralProficient Rx LP2009-08-04Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCarilion Materials Management2014-01-01Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralCardinal Health2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/301oralNorthwind Pharmaceuticals2014-05-07Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralRebel Distributors Corp2009-08-03Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralPhysicians Total Care, Inc.2008-02-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2012-01-27Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMedsource Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralAmerican Health Packaging2014-03-06Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralREMEDYREPACK INC.2016-01-12Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralBlue Point Laboratories2013-11-25Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralProficient Rx LP2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralGolden State Medical Supply, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralbryant ranch prepack2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralUnit Dose Services2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralCardinal Health2010-08-13Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/301oralNorthwind Pharmaceuticals2014-05-06Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralRebel Distributors Corp2010-04-15Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralPhysicians Total Care, Inc.2007-08-03Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralCardinal Health2012-01-27Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2011-02-02Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralClinical Solutions Wholesale2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralAmerican Health Packaging2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release200 mg/1oralGolden State Medical Supply, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralBlue Point Laboratories2014-01-01Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralActavis Pharma, Inc.2010-04-15Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralLegacy Pharmaceutical Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralMylan Institutional Inc.2012-01-27Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralREMEDYREPACK INC.2013-03-082016-04-05Us
Metoprolol Succinatetablet, extended release50 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralCardinal Health2014-05-12Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralbryant ranch prepack2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralUnit Dose Services2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMajor Pharmaceuticals2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release200 mg/1oralMylan Pharmaceuticals Inc.2011-12-21Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralPhysicians Total Care, Inc.2010-01-05Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralWockhardt USA LLC.2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release25 mg/1oralGolden State Medical Supply, Inc.2013-03-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralActavis Pharma, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release25 mg/1oralProficient Rx LP2009-08-04Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCardinal Health2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralMc Kesson Contract Packaging2012-09-10Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralInternational Labs, Inc.2011-09-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralMajor Pharmaceuticals2010-10-05Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralCardinal Health2014-03-06Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralWockhardt Limited2010-07-22Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralClinical Solutions Wholesale2010-07-22Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralSt Marys Medical Park Pharmacy2013-08-08Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralAmerican Health Packaging2014-05-12Not applicableUs
Metoprolol Succinatetablet, extended release50 mg/1oralBlue Point Laboratories2014-01-01Not applicableUs
Metoprolol Succinatetablet, film coated, extended release50 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-04Not applicableUs
Metoprolol Succinatetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2013-06-172016-04-05Us
Metoprolol Succinatetablet, extended release25 mg/1oralAidarex Pharmaceuticals LLC2012-09-10Not applicableUs
Metoprolol Succinatetablet, extended release100 mg/1oralDr. Reddy's Laboratories Limited2012-09-10Not applicableUs
Metoprolol Succinate E/rtablet, film coated, extended release50 mg/1oralDIRECT RX2015-01-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release47.5 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release23.75 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release190 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Succinate Extended-releasetablet, film coated, extended release90 mg/1oralEthex Corporation2009-11-01Not applicableUs
Metoprolol Tartatetablet50 mg/1oralNorthwind Pharmaceuticals2014-06-02Not applicableUs
Metoprolol Tartatetablet100 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralRebel Distributors Corp.2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousPhysicians Total Care, Inc.2006-12-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralContract Pharmacy Services Pa2009-06-10Not applicableUs
Metoprolol Tartratetablet50 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralProficient Rx LP1997-07-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMc Kesson Contract Packaging2011-11-04Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralA S Medication Solutions2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Metoprolol Tartratetablet50 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-19Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc1995-04-06Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMylan Institutional Inc.1994-05-03Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet25 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Metoprolol Tartratetablet100 mg/1oralLake Erie Medical DBA Quality Care Products LLC1997-07-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2010-06-09Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralTYA Pharmaceuticals2009-03-24Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSt Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metoprolol Tartrateinjection5 mg/5mLintravenousGland Pharma Limited2014-10-06Not applicableUs
Metoprolol Tartratetablet50 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralActavis Pharma, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2015-01-13Not applicableUs
Metoprolol Tartratetablet, film coated37.5 mg/1oralMylan Pharmaceuticals Inc.2016-03-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralGreenstone LLC2007-09-112015-10-31Us
Metoprolol Tartratetablet100 mg/1oralCardinal Health2014-03-14Not applicableUs
Metoprolol Tartratetablet100 mg/1oralREMEDYREPACK INC.2011-11-02Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousHospira, Inc.1993-12-21Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralBlenheim Pharmacal, Inc.2013-07-10Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCardinal Health2004-01-15Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCardinal Health2013-08-25Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSandoz Inc1994-03-25Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAmerican Health Packaging2010-07-26Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralUnit Dose Services2009-03-15Not applicableUs
Metoprolol Tartratetablet100 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralUnit Dose Services2009-03-24Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMylan Pharmaceuticals Inc.2004-02-23Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSTAT Rx USA LLC1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralREMEDYREPACK INC.2014-04-24Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPhysicians Total Care, Inc.1994-01-05Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralbryant ranch prepack2009-03-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMed Vantx, Inc.1995-04-06Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartratetablet25 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health2010-02-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet25 mg/1oralbryant ranch prepack2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralDispensing Solutions, Inc.2004-01-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralProficient Rx LP1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health1997-07-012015-12-29Us
Metoprolol Tartratetablet, film coated100 mg/1oralA S Medication Solutions2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralTeva Pharmaceuticals USA Inc1995-04-06Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMylan Institutional Inc.1994-05-03Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMajor Pharmaceuticals2010-05-17Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousCardinal Health2008-05-05Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-15Not applicableUs
Metoprolol Tartratetablet25 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSt Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metoprolol Tartratetablet100 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralPreferred Pharmaceuticals, Inc.2013-04-01Not applicableUs
Metoprolol Tartratetablet, film coated75 mg/1oralMylan Pharmaceuticals Inc.2016-03-01Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralSandoz Inc1994-03-25Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet100 mg/1oralREMEDYREPACK INC.2011-12-01Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousHospira, Inc.1998-07-06Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.2010-10-08Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralCardinal Health2013-08-25Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralContract Pharmacy Services Pa2011-01-25Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2015-05-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCarilion Materials Management2007-09-11Not applicableUs
Metoprolol Tartratetablet25 mg/1oralProficient Rx LP2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMc Kesson Contract Packaging2011-10-06Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Metoprolol Tartratetablet100 mg/1oralUnit Dose Services1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.1993-12-23Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralRebel Distributors Corp.1996-12-10Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralPhysicians Total Care, Inc.1994-11-29Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet50 mg/1oralREMEDYREPACK INC.2011-07-07Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2013-04-22Not applicableUs
Metoprolol Tartratetablet100 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralGreenstone LLC2007-09-112016-03-31Us
Metoprolol Tartratetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralCardinal Health1997-07-012015-12-29Us
Metoprolol Tartratetablet, film coated50 mg/1oralREMEDYREPACK INC.2016-04-04Not applicableUs
Metoprolol Tartratetablet25 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-16Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousWest Ward Pharmaceuticals Corp2007-05-30Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet50 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Metoprolol Tartratetablet50 mg/1oralLake Erie Medical DBA Quality Care Products LLC1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCardinal Health2013-07-23Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAmerican Health Packaging2010-06-09Not applicableUs
Metoprolol Tartratetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1997-07-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-14Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2016-03-21Not applicableUs
Metoprolol Tartratetablet25 mg/1oralSun Pharmaceutical Industries, Inc.2004-01-15Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralProficient Rx LP2007-09-11Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousSandoz Inc2007-10-02Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet, film coated25 mg/1oralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousAmerican Regent, Inc.2010-02-11Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAidarex Pharmaceuticals LLC1994-05-27Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2013-12-20Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health1998-07-06Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCardinal Health2011-01-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCitron Pharma LLC2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralContract Pharmacy Services Pa2009-06-10Not applicableUs
Metoprolol Tartratetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Metoprolol Tartratetablet25 mg/1oralCarilion Materials Management2014-03-14Not applicableUs
Metoprolol Tartratetablet50 mg/1oralProficient Rx LP2004-01-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMc Kesson Contract Packaging2011-10-04Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Metoprolol Tartratetablet25 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.1993-12-23Not applicableUs
Metoprolol Tartratetablet100 mg/1oralRebel Distributors Corp.1996-12-10Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralLucid Pharma Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralVensun Pharmaceuticals, Inc.2015-08-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralPhysicians Total Care, Inc.2004-03-15Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health1998-07-06Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralREMEDYREPACK INC.2016-04-08Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralIngenus Pharmaceuticals, LLC2011-05-01Not applicableUs
Metoprolol Tartratetablet100 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-12Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-03-19Not applicableUs
Metoprolol Tartratetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Metoprolol Tartratetablet100 mg/1oralMajor Pharmaceuticals2014-03-14Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2013-04-22Not applicableUs
Metoprolol Tartratetablet50 mg/1oralSun Pharmaceutical Industries, Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-04-22Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralLegacy Pharmaceutical Packaging, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralCardinal Health2010-01-122015-12-29Us
Metoprolol Tartratetablet50 mg/1oralAlembic Pharmaceuticals Limited2014-03-14Not applicableUs
Metoprolol Tartratetablet25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2004-01-15Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousWest Ward Pharmaceuticals Corp2007-05-30Not applicableUs
Metoprolol Tartratetablet50 mg/1oralMed Health Pharma, LLC2011-01-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAurolife Pharma LLC2010-09-17Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralREMEDYREPACK INC.2014-02-20Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCardinal Health2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralbryant ranch prepack2009-03-15Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralAurobindo Pharma Limited2007-09-11Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAmerican Health Packaging2010-06-22Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-05Not applicableUs
Metoprolol Tartratetablet50 mg/1oralPreferred Pharmaceuticals, Inc.2012-02-14Not applicableUs
Metoprolol Tartrateinjection, solution1 mg/mLintravenousCardinal Health2008-04-29Not applicableUs
Metoprolol Tartrateinjection, solution5 mg/5mLintravenousCardinal Health2007-05-30Not applicableUs
Metoprolol Tartratetablet100 mg/1oralClinical Solutions Wholesale1997-07-01Not applicableUs
Metoprolol Tartratetablet50 mg/1oralTYA Pharmaceuticals1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Metoprolol Tartratetablet25 mg/1oralAlembic Pharmaceuticals Inc.2015-10-15Not applicableUs
Metoprolol Tartratetablet50 mg/1oralPreferred Pharmaceuticals Inc.1997-07-01Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralRanbaxy Pharmaceuticals Inc.2009-03-24Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Metoprolol Tartratetablet, film coated100 mg/1oralCronus Pharma LLC2007-09-112016-01-05Us
Metoprolol Tartratetablet, film coated50 mg/1oralRubicon Research Private Limited2014-11-17Not applicableUs
Metoprolol Tartratetablet, film coated25 mg/1oralMylan Institutional Inc.2004-09-20Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralActavis Pharma, Inc.1994-05-27Not applicableUs
Metoprolol Tartratetablet50 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Metoprolol Tartratetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-09-11Not applicableUs
Metoprolol Tartratetablet100 mg/1oralBlenheim Pharmacal, Inc.2013-10-21Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CorvitolNot Available
MinaxNot Available
SelokeenNot Available
TOPROLNot Available
Toprol-XLNot Available
TOPROLXLNot Available
Brand mixtures
NameLabellerIngredients
DutoprolAstra Zeneca Lp
HypertensololPhysician Therapeutics Llc
Lopressor HctValidus Pharmaceuticals LLC
Metoprolol Tartrate and HydrochlorothiazideMylan Pharmaceuticals Inc.
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-25 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 100 Mg-50 mgNorth Star Rx Llc
Metoprolol Tartrate and Hydrochlorothiazide 50 Mg-25 mgNorth Star Rx Llc
Salts
Name/CASStructureProperties
Metoprolol fumarate
119637-66-0
Thumb
  • InChI Key: BRIPGNJWPCKDQZ-WXXKFALUSA-N
  • Monoisotopic Mass: 650.377845947
  • Average Mass: 650.81
DBSALT001329
Metoprolol succinate
98418-47-4
Thumb
  • InChI Key: RGHAZVBIOOEVQX-UHFFFAOYSA-N
  • Monoisotopic Mass: 652.393496011
  • Average Mass: 652.826
DBSALT000863
Metoprolol tartrate
56392-17-7
Thumb
  • InChI Key: YGULWPYYGQCFMP-CEAXSRTFSA-N
  • Monoisotopic Mass: 684.383325251
  • Average Mass: 684.824
DBSALT000862
Categories
UNIIGEB06NHM23
CAS number51384-51-1
WeightAverage: 267.3639
Monoisotopic: 267.183443671
Chemical FormulaC15H25NO3
InChI KeyInChIKey=IUBSYMUCCVWXPE-UHFFFAOYSA-N
InChI
InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
IUPAC Name
1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol
SMILES
COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tyrosols and derivatives. These are compounds containing a hydroxyethyl group attached to the C4 carbon of a phenol group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenols and derivatives
Direct ParentTyrosols and derivatives
Alternative Parents
Substituents
  • Tyrosol derivative
  • Phenol ether
  • Alkyl aryl ether
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
PharmacodynamicsMetoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
Mechanism of actionMetoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Related Articles
AbsorptionRapid and complete, 50%
Volume of distributionNot Available
Protein binding12%
Metabolism

Primarily hepatic

SubstrateEnzymesProduct
Metoprolol
alpha-HydroxymetoprololDetails
Route of eliminationLess than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.
Half life3-7 hours
ClearanceNot Available
ToxicityLD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Metoprolol Action PathwayDrug actionSMP00302
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableC AlleleImproved response to blood pressure medication12844134
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801252 Not AvailableA AlleleImproved response to blood pressure medication12844134
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy12844134
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A alleleIncreased risk of slow heart rate (bradycardia)18784654
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9854
Blood Brain Barrier-0.8426
Caco-2 permeable+0.6895
P-glycoprotein substrateSubstrate0.7317
P-glycoprotein inhibitor INon-inhibitor0.8182
P-glycoprotein inhibitor IINon-inhibitor0.8382
Renal organic cation transporterNon-inhibitor0.8418
CYP450 2C9 substrateNon-substrate0.81
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.6527
CYP450 1A2 substrateNon-inhibitor0.7018
CYP450 2C9 inhibitorNon-inhibitor0.8691
CYP450 2D6 inhibitorNon-inhibitor0.7909
CYP450 2C19 inhibitorNon-inhibitor0.9555
CYP450 3A4 inhibitorNon-inhibitor0.9476
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9897
Ames testNon AMES toxic0.9163
CarcinogenicityNon-carcinogens0.9387
BiodegradationNot ready biodegradable0.8544
Rat acute toxicity1.9180 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8368
hERG inhibition (predictor II)Non-inhibitor0.8202
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novartis pharmaceuticals corp
  • Kv pharmaceutical co
  • Sandoz inc
  • Watson laboratories inc florida
  • Wockhardt ltd
  • Astrazeneca lp
  • Bedford laboratories
  • Hikma farmaceutica (portugal) sa
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Sagent strides llc
  • Sandoz canada inc
  • Watson laboratories inc
  • Apothecon inc div bristol myers squibb
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Ipca laboratories ltd
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Solco healthcare us llc
  • Teva pharmaceuticals usa inc
  • Teva pharmaceuticals usa
Packagers
Dosage forms
FormRouteStrength
Tabletoral25 mg
Tablet, film coatedoral
Kit
Liquidintravenous1 mg
Tablet (extended-release)oral100 mg
Tablet (extended-release)oral200 mg
Injection, solutionintravenous5 mg/5mL
Tabletoral100 mg/1
Tabletoral50 mg/1
Injectionintravenous5 mg/5mL
Tablet, film coated, extended releaseoral100 mg/1
Tablet, film coated, extended releaseoral200 mg/1
Tablet, film coated, extended releaseoral25 mg/301
Tablet, film coated, extended releaseoral25 mg/1
Tablet, film coated, extended releaseoral50 mg/1
Tablet, film coated, extended releaseoral50 mg/301
Tablet, film coated, extended releaseoral190 mg/1
Tablet, film coated, extended releaseoral23.75 mg/1
Tablet, film coated, extended releaseoral47.5 mg/1
Tablet, film coated, extended releaseoral90 mg/1
Injection, solutionintravenous1 mg/mL
Tabletoral25 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral37.5 mg/1
Tablet, film coatedoral50 mg/1
Tablet, film coatedoral75 mg/1
Tabletoral
Solutionintravenous1 mg
Tabletoral100 mg
Tabletoral50 mg
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, extended releaseoral25 mg/1
Tablet, extended releaseoral50 mg/1
Prices
Unit descriptionCostUnit
Metoprolol tartrate powder5.51USD g
Lopressor 5 mg/5 ml ampul3.85USD ml
Lopressor hct 100-25 tablet3.21USD tablet
Toprol XL 200 mg 24 Hour tablet3.08USD tablet
Lopressor HCT 100-50 mg tablet3.06USD tablet
Toprol xl 200 mg tablet2.96USD tablet
Lopressor hct 100-50 tablet2.82USD tablet
Lopressor 100 mg tablet2.75USD tablet
Metoprolol Succinate 200 mg 24 Hour tablet2.62USD tablet
Metoprolol succ er 200 mg tablet2.29USD tablet
Lopressor HCT 100-25 mg tablet2.21USD tablet
Lopressor HCT 50-25 mg tablet2.14USD tablet
Lopressor hct 50-25 tablet2.06USD tablet
Toprol XL 100 mg 24 Hour tablet1.93USD tablet
Toprol xl 100 mg tablet1.86USD tablet
Lopressor 50 mg tablet1.81USD tablet
Metoprolol Succinate 100 mg 24 Hour tablet1.53USD tablet
Metoprolol succ er 100 mg tablet1.44USD tablet
Toprol XL 25 mg 24 Hour tablet1.43USD tablet
Toprol XL 50 mg 24 Hour tablet1.43USD tablet
Lopresor 1 mg/ml1.29USD ml
Toprol xl 25 mg tablet1.24USD tablet
Toprol xl 50 mg tablet1.24USD tablet
Metoprolol Succinate 25 mg 24 Hour tablet1.17USD tablet
Metoprolol Succinate 50 mg 24 Hour tablet1.13USD tablet
Metoprolol succ er 50 mg tablet0.9USD tablet
Metoprolol succ er 25 mg tablet0.87USD tablet
Metoprolol tartrate 100 mg tablet0.8USD tablet
Toprol xl 100 mg tablet sa0.8USD tablet
Lopresor 100 mg Tablet0.61USD tablet
Lopresor Sr 200 mg Sustained-Release Tablet0.61USD tablet
Metoprolol tartrate 50 mg tablet0.56USD tablet
Metoprolol tartrate 25 mg tablet0.34USD tablet
Apo-Metoprolol Sr 200 mg Sustained-Release Tablet0.34USD tablet
Lopresor Sr 100 mg Sustained-Release Tablet0.34USD tablet
Sandoz Metoprolol Sr 200 mg Sustained-Release Tablet0.34USD tablet
Lopresor 50 mg Tablet0.3USD tablet
Apo-Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Apo-Metoprolol 100 mg Tablet0.23USD tablet
Mylan-Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Novo-Metoprol (Fc) 100 mg Tablet0.23USD tablet
Novo-Metoprol 100 mg Tablet0.23USD tablet
Nu-Metop 100 mg Tablet0.23USD tablet
Pms-Metoprolol-L 100 mg Tablet0.23USD tablet
Sandoz Metoprolol (Type L) 100 mg Tablet0.23USD tablet
Apo-Metoprolol Sr 100 mg Sustained-Release Tablet0.19USD tablet
Sandoz Metoprolol Sr 100 mg Sustained-Release Tablet0.19USD tablet
Apo-Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Apo-Metoprolol 50 mg Tablet0.13USD tablet
Mylan-Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Novo-Metoprol (Fc) 50 mg Tablet0.13USD tablet
Novo-Metoprol 50 mg Tablet0.13USD tablet
Nu-Metop 50 mg Tablet0.13USD tablet
Pms-Metoprolol-L 50 mg Tablet0.13USD tablet
Sandoz Metoprolol (Type L) 50 mg Tablet0.13USD tablet
Apo-Metoprolol 25 mg Tablet0.07USD tablet
Pms-Metoprolol-L 25 mg Tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point120 °C (tartarate salt)Not Available
water solubility1.69E+004 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP1.88HANSCH,C ET AL. (1995)
Caco2 permeability-4.59ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.402 mg/mLALOGPS
logP1.8ALOGPS
logP1.76ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)14.09ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area50.72 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity76.7 m3·mol-1ChemAxon
Polarizability31.9 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-0v0c-3248359000-0353ef81c3bc6d7fcfd5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-014l-2514911000-b5f7785723f1eaf61e6fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-05ir-1729351100-fb362124379cb4616c5eView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US3998790
General References
  1. Authors unspecified: Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7. [PubMed:10376614 ]
External Links
ATC CodesC07BB02C07AB02C07AB52C07BB52C07CB02C07FB02
AHFS Codes
  • 24:24.00
PDB EntriesNot Available
FDA labelDownload (439 KB)
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
1,10-Phenanthroline1,10-Phenanthroline may increase the bradycardic activities of Metoprolol.
4-Methoxyamphetamine4-Methoxyamphetamine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Metoprolol.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Metoprolol.
AbirateroneThe metabolism of Metoprolol can be decreased when combined with Abiraterone.
AcebutololMetoprolol may increase the hypotensive activities of Acebutolol.
AceclofenacAceclofenac may decrease the antihypertensive activities of Metoprolol.
AcepromazineAcepromazine may increase the hypotensive activities of Metoprolol.
AcetaminophenThe serum concentration of Metoprolol can be increased when it is combined with Acetaminophen.
AcetazolamideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Acetazolamide.
AcetohexamideMetoprolol may increase the hypoglycemic activities of Acetohexamide.
AcetylcholineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Acetylcholine.
AcetyldigitoxinMetoprolol may increase the bradycardic activities of Acetyldigitoxin.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Metoprolol.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Metoprolol.
AdapaleneAdapalene may decrease the antihypertensive activities of Metoprolol.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Metoprolol.
AgmatineAgmatine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
AjmalineThe serum concentration of Metoprolol can be increased when it is combined with Ajmaline.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Metoprolol.
AlbendazoleThe serum concentration of Metoprolol can be increased when it is combined with Albendazole.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Metoprolol.
AldosteroneThe serum concentration of Metoprolol can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Metoprolol.
AlectinibThe serum concentration of Metoprolol can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Metoprolol can be increased when it is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the hypotensive activities of Metoprolol.
AlfuzosinMetoprolol may increase the orthostatic hypotensive activities of Alfuzosin.
AlimemazineAlimemazine may increase the hypotensive activities of Metoprolol.
AliskirenMetoprolol may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Metoprolol.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Metoprolol.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Metoprolol.
AlprenololMetoprolol may increase the hypotensive activities of Alprenolol.
AmantadineThe serum concentration of Metoprolol can be increased when it is combined with Amantadine.
AmbenoniumAmbenonium may increase the bradycardic activities of Metoprolol.
AmbrisentanMetoprolol may increase the hypotensive activities of Ambrisentan.
AmifostineMetoprolol may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Amiloride.
Aminohippuric acidThe serum concentration of Metoprolol can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Metoprolol.
AminophyllineMetoprolol may decrease the bronchodilatory activities of Aminophylline.
AmiodaroneAmiodarone may increase the bradycardic activities of Metoprolol.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Metoprolol.
AmlodipineMetoprolol may increase the hypotensive activities of Amlodipine.
AmobarbitalAmobarbital may increase the hypotensive activities of Metoprolol.
AmodiaquineThe metabolism of Metoprolol can be decreased when combined with Amodiaquine.
AmoxapineThe serum concentration of Metoprolol can be increased when it is combined with Amoxapine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Metoprolol.
AmphetamineThe serum concentration of Metoprolol can be increased when it is combined with Amphetamine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Metoprolol.
AmprenavirThe serum concentration of Metoprolol can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Metoprolol.
AmsacrineThe serum concentration of Metoprolol can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Metoprolol.
Amyl NitriteThe risk or severity of adverse effects can be increased when Metoprolol is combined with Amyl Nitrite.
AntipyrineAntipyrine may decrease the antihypertensive activities of Metoprolol.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Metoprolol.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Metoprolol.
ApomorphineApomorphine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
ApraclonidineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Apraclonidine.
ApremilastApremilast may decrease the antihypertensive activities of Metoprolol.
AprindineThe metabolism of Aprindine can be decreased when combined with Metoprolol.
ArbutamineMetoprolol may decrease the bronchodilatory activities of Arbutamine.
ArecolineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Arecoline.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Metoprolol.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Metoprolol.
AripiprazoleAripiprazole may increase the hypotensive activities of Metoprolol.
ArmodafinilThe metabolism of Metoprolol can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Metoprolol.
ArtemetherThe metabolism of Artemether can be decreased when combined with Metoprolol.
AsenapineThe serum concentration of Metoprolol can be increased when it is combined with Asenapine.
AstemizoleThe serum concentration of Metoprolol can be increased when it is combined with Astemizole.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Metoprolol.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Metoprolol.
AtenololMetoprolol may increase the hypotensive activities of Atenolol.
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Metoprolol.
AtorvastatinThe serum concentration of Metoprolol can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Metoprolol.
AzapropazoneAzapropazone may decrease the antihypertensive activities of Metoprolol.
AzelastineAzelastine may decrease the antihypertensive activities of Metoprolol.
AzelastineThe metabolism of Azelastine can be decreased when combined with Metoprolol.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Metoprolol is combined with Azilsartan medoxomil.
AzithromycinThe serum concentration of Metoprolol can be increased when it is combined with Azithromycin.
BalsalazideBalsalazide may decrease the antihypertensive activities of Metoprolol.
BambuterolMetoprolol may decrease the bronchodilatory activities of Bambuterol.
BarbitalBarbital may increase the hypotensive activities of Metoprolol.
BenazeprilMetoprolol may increase the hypotensive activities of Benazepril.
BendroflumethiazideMetoprolol may increase the hypotensive activities of Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypotensive activities of Metoprolol.
BenoxaprofenBenoxaprofen may decrease the antihypertensive activities of Metoprolol.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Metoprolol.
BenzocaineThe serum concentration of Metoprolol can be increased when it is combined with Benzocaine.
BenzphetamineBenzphetamine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Metoprolol.
BepridilMetoprolol may increase the hypotensive activities of Bepridil.
BeractantMetoprolol may increase the bradycardic activities of Beractant.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Metoprolol.
BetaxololBetaxolol may increase the hypotensive activities of Metoprolol.
BethanecholThe risk or severity of adverse effects can be increased when Metoprolol is combined with Bethanechol.
BethanidineBethanidine may increase the hypotensive activities of Metoprolol.
BicalutamideThe serum concentration of Metoprolol can be increased when it is combined with Bicalutamide.
BimatoprostMetoprolol may increase the hypotensive activities of Bimatoprost.
BiperidenThe serum concentration of Metoprolol can be increased when it is combined with Biperiden.
BisoprololMetoprolol may increase the hypotensive activities of Bisoprolol.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Metoprolol.
BortezomibThe metabolism of Bortezomib can be decreased when combined with Metoprolol.
BosentanMetoprolol may increase the hypotensive activities of Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Metoprolol.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Metoprolol.
BretyliumBretylium may increase the bradycardic activities of Metoprolol.
BretyliumMetoprolol may increase the hypotensive activities of Bretylium.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Metoprolol.
BrimonidineMetoprolol may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Metoprolol.
BromfenacBromfenac may decrease the antihypertensive activities of Metoprolol.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Metoprolol.
BrompheniramineThe serum concentration of Metoprolol can be increased when it is combined with Brompheniramine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Metoprolol.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Metoprolol.
BumetanideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Bumetanide.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Metoprolol.
BupranololMetoprolol may increase the hypotensive activities of Bupranolol.
BuprenorphineThe serum concentration of Metoprolol can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Metoprolol.
BupropionThe serum concentration of Metoprolol can be increased when it is combined with Bupropion.
BupropionThe metabolism of Bupropion can be decreased when combined with Metoprolol.
BuspironeThe serum concentration of Metoprolol can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Metoprolol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Metoprolol.
CabergolineMetoprolol may increase the vasoconstricting activities of Cabergoline.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Metoprolol.
CalfactantMetoprolol may increase the bradycardic activities of Calfactant.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Metoprolol.
CanagliflozinThe risk or severity of adverse effects can be increased when Metoprolol is combined with Canagliflozin.
CandesartanMetoprolol may increase the hypotensive activities of Candesartan.
CandoxatrilMetoprolol may increase the hypotensive activities of Candoxatril.
CaptoprilMetoprolol may increase the hypotensive activities of Captopril.
CarbacholThe risk or severity of adverse effects can be increased when Metoprolol is combined with Carbachol.
CarbamazepineThe serum concentration of Metoprolol can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Metoprolol.
CarbinoxamineThe serum concentration of Metoprolol can be increased when it is combined with Carbinoxamine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Metoprolol.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Metoprolol.
CaroxazoneCaroxazone may increase the hypotensive activities of Metoprolol.
CarprofenCarprofen may decrease the antihypertensive activities of Metoprolol.
CarteololMetoprolol may increase the hypotensive activities of Carteolol.
CarvedilolMetoprolol may increase the hypotensive activities of Carvedilol.
CaspofunginThe serum concentration of Metoprolol can be increased when it is combined with Caspofungin.
CastanospermineCastanospermine may decrease the antihypertensive activities of Metoprolol.
CelecoxibCelecoxib may decrease the antihypertensive activities of Metoprolol.
CeliprololMetoprolol may increase the hypotensive activities of Celiprolol.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Metoprolol.
CeritinibMetoprolol may increase the bradycardic activities of Ceritinib.
CerivastatinThe serum concentration of Metoprolol can be increased when it is combined with Cerivastatin.
CevimelineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Cevimeline.
ChloramphenicolThe metabolism of Metoprolol can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Metoprolol.
ChloroquineChloroquine may decrease the antihypertensive activities of Metoprolol.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Metoprolol.
ChlorothiazideMetoprolol may increase the hypotensive activities of Chlorothiazide.
ChlorphenamineThe serum concentration of Metoprolol can be increased when it is combined with Chlorphenamine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Metoprolol.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Metoprolol.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Metoprolol.
ChlorpropamideMetoprolol may increase the hypoglycemic activities of Chlorpropamide.
ChlorpropamideThe serum concentration of Metoprolol can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Metoprolol can be increased when it is combined with Chlorprothixene.
ChlorthalidoneMetoprolol may increase the hypotensive activities of Chlorthalidone.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Metoprolol.
CholecalciferolThe metabolism of Metoprolol can be decreased when combined with Cholecalciferol.
CholesterolThe serum concentration of Metoprolol can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Metoprolol can be decreased when it is combined with Cholic Acid.
CilazaprilMetoprolol may increase the hypotensive activities of Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Metoprolol.
CimetidineThe serum concentration of Metoprolol can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Metoprolol.
CinacalcetThe serum concentration of Metoprolol can be increased when it is combined with Cinacalcet.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Metoprolol.
CiprofloxacinThe serum concentration of Metoprolol can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Metoprolol can be increased when it is combined with Cisapride.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Metoprolol.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Metoprolol.
ClarithromycinThe serum concentration of Metoprolol can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Metoprolol can be decreased when combined with Clemastine.
ClenbuterolMetoprolol may decrease the bronchodilatory activities of Clenbuterol.
ClevidipineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Clevidipine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Metoprolol.
ClobazamThe metabolism of Metoprolol can be decreased when combined with Clobazam.
ClofazimineThe serum concentration of Metoprolol can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Metoprolol.
ClomipramineThe serum concentration of Metoprolol can be increased when it is combined with Clomipramine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Metoprolol.
ClonidineMetoprolol may increase the hypotensive activities of Clonidine.
ClonixinClonixin may decrease the antihypertensive activities of Metoprolol.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Metoprolol.
ClotrimazoleThe serum concentration of Metoprolol can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Metoprolol.
ClozapineThe metabolism of Metoprolol can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Metoprolol can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Metoprolol.
CocaineThe serum concentration of Metoprolol can be increased when it is combined with Cocaine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Metoprolol.
CodeineThe serum concentration of Metoprolol can be increased when it is combined with Codeine.
ColchicineThe serum concentration of Metoprolol can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Metoprolol can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Metoprolol.
CoumaphosCoumaphos may increase the bradycardic activities of Metoprolol.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Metoprolol.
CryptenamineMetoprolol may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Metoprolol.
CyclophosphamideThe serum concentration of Metoprolol can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Metoprolol.
CyclosporineThe serum concentration of Metoprolol can be decreased when it is combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Metoprolol.
CyclothiazideMetoprolol may increase the hypotensive activities of Cyclothiazide.
D-LimoneneD-Limonene may decrease the antihypertensive activities of Metoprolol.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Metoprolol.
DabrafenibThe serum concentration of Metoprolol can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Metoprolol.
DaclatasvirThe serum concentration of Metoprolol can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Metoprolol can be increased when it is combined with Dactinomycin.
DapagliflozinThe risk or severity of adverse effects can be increased when Metoprolol is combined with Dapagliflozin.
DapoxetineThe serum concentration of Metoprolol can be increased when it is combined with Dapoxetine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Metoprolol.
DarunavirThe serum concentration of Metoprolol can be increased when it is combined with Darunavir.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Metoprolol.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Metoprolol.
DaunorubicinThe serum concentration of Metoprolol can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Metoprolol.
DebrisoquinMetoprolol may increase the hypotensive activities of Debrisoquin.
DecamethoniumDecamethonium may increase the bradycardic activities of Metoprolol.
DelavirdineThe serum concentration of Metoprolol can be increased when it is combined with Delavirdine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Metoprolol.
DemecariumDemecarium may increase the bradycardic activities of Metoprolol.
DeserpidineMetoprolol may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Metoprolol can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Metoprolol.
DeslanosideMetoprolol may increase the bradycardic activities of Deslanoside.
DesloratadineThe serum concentration of Metoprolol can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Metoprolol can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Metoprolol.
DexfenfluramineThe serum concentration of Metoprolol can be increased when it is combined with Dexfenfluramine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Metoprolol.
DexmedetomidineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Dexmedetomidine.
DexmethylphenidateThe serum concentration of Metoprolol can be increased when it is combined with Dexmethylphenidate.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Metoprolol.
DextroamphetamineThe serum concentration of Metoprolol can be increased when it is combined with Dextroamphetamine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Metoprolol.
DextromethorphanThe serum concentration of Metoprolol can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Metoprolol.
DextropropoxypheneThe serum concentration of Metoprolol can be increased when it is combined with Dextropropoxyphene.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Metoprolol.
DiazoxideDiazoxide may increase the hypotensive activities of Metoprolol.
DichlorvosDichlorvos may increase the bradycardic activities of Metoprolol.
DiclofenacDiclofenac may decrease the antihypertensive activities of Metoprolol.
DiclofenamideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Diclofenamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Metoprolol.
DiflunisalDiflunisal may decrease the antihypertensive activities of Metoprolol.
DigitoxinMetoprolol may increase the bradycardic activities of Digitoxin.
DigoxinMetoprolol may increase the bradycardic activities of Digoxin.
DigoxinThe serum concentration of Metoprolol can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Metoprolol.
DihydroergotamineMetoprolol may increase the vasoconstricting activities of Dihydroergotamine.
DihydroergotamineThe serum concentration of Metoprolol can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Metoprolol.
DiltiazemMetoprolol may increase the hypotensive activities of Diltiazem.
Dimethyl sulfoxideThe serum concentration of Metoprolol can be increased when it is combined with Dimethyl sulfoxide.
DinutuximabThe risk or severity of adverse effects can be increased when Metoprolol is combined with Dinutuximab.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Metoprolol.
DipivefrinDipivefrin may increase the atrioventricular blocking (AV block) activities of Metoprolol.
DipivefrinMetoprolol may decrease the bronchodilatory activities of Dipivefrin.
DipyridamoleDipyridamole may increase the bradycardic activities of Metoprolol.
DipyridamoleThe risk or severity of adverse effects can be increased when Metoprolol is combined with Dipyridamole.
DisopyramideDisopyramide may increase the bradycardic activities of Metoprolol.
DobutamineMetoprolol may decrease the bronchodilatory activities of Dobutamine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Metoprolol.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Metoprolol.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Metoprolol.
DonepezilDonepezil may increase the bradycardic activities of Metoprolol.
DopamineThe metabolism of Dopamine can be decreased when combined with Metoprolol.
DorzolamideMetoprolol may increase the hypotensive activities of Dorzolamide.
DoxazosinMetoprolol may increase the hypotensive activities of Doxazosin.
DoxepinThe serum concentration of Metoprolol can be increased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Metoprolol.
DoxorubicinThe serum concentration of Metoprolol can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Metoprolol.
DronabinolThe serum concentration of Metoprolol can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Metoprolol can be increased when it is combined with Dronedarone.
DronedaroneMetoprolol may increase the bradycardic activities of Dronedarone.
DroxicamDroxicam may decrease the antihypertensive activities of Metoprolol.
DroxidopaDroxidopa may increase the atrioventricular blocking (AV block) activities of Metoprolol.
DroxidopaMetoprolol may decrease the bronchodilatory activities of Droxidopa.
DuloxetineMetoprolol may increase the orthostatic hypotensive activities of Duloxetine.
DuloxetineThe metabolism of Metoprolol can be decreased when combined with Duloxetine.
DyphyllineMetoprolol may decrease the bronchodilatory activities of Dyphylline.
EchothiophateEchothiophate may increase the bradycardic activities of Metoprolol.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Metoprolol.
EdrophoniumEdrophonium may increase the bradycardic activities of Metoprolol.
EfavirenzThe metabolism of Metoprolol can be decreased when combined with Efavirenz.
EfonidipineMetoprolol may increase the hypotensive activities of Efonidipine.
ElbasvirThe serum concentration of Metoprolol can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Metoprolol.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Metoprolol.
EmpagliflozinThe risk or severity of adverse effects can be increased when Metoprolol is combined with Empagliflozin.
EnalaprilMetoprolol may increase the hypotensive activities of Enalapril.
EnalaprilatMetoprolol may increase the hypotensive activities of Enalaprilat.
EncainideThe metabolism of Encainide can be decreased when combined with Metoprolol.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Metoprolol.
EnzalutamideThe serum concentration of Metoprolol can be increased when it is combined with Enzalutamide.
EphedraEphedra may increase the atrioventricular blocking (AV block) activities of Metoprolol.
EphedraMetoprolol may decrease the bronchodilatory activities of Ephedra.
EPIBATIDINEThe risk or severity of adverse effects can be increased when Metoprolol is combined with EPIBATIDINE.
EpinastineThe serum concentration of Metoprolol can be increased when it is combined with Epinastine.
EpinephrineEpinephrine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
EpinephrineMetoprolol may decrease the bronchodilatory activities of Epinephrine.
EpirizoleEpirizole may decrease the antihypertensive activities of Metoprolol.
EplerenoneThe risk or severity of adverse effects can be increased when Metoprolol is combined with Eplerenone.
EpoprostenolMetoprolol may increase the hypotensive activities of Epoprostenol.
EprosartanMetoprolol may increase the hypotensive activities of Eprosartan.
Ergoloid mesylateMetoprolol may increase the vasoconstricting activities of Ergoloid mesylate.
ErgonovineMetoprolol may increase the vasoconstricting activities of Ergonovine.
ErgonovineThe serum concentration of Metoprolol can be increased when it is combined with Ergonovine.
ErgotamineMetoprolol may increase the vasoconstricting activities of Ergotamine.
ErgotamineThe serum concentration of Metoprolol can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Metoprolol.
ErythromycinThe serum concentration of Metoprolol can be decreased when it is combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Metoprolol.
EscitalopramThe serum concentration of Metoprolol can be increased when it is combined with Escitalopram.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Metoprolol.
Eslicarbazepine acetateThe metabolism of Metoprolol can be decreased when combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Metoprolol.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Metoprolol.
EsomeprazoleThe metabolism of Metoprolol can be decreased when combined with Esomeprazole.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Metoprolol.
EstramustineThe serum concentration of Metoprolol can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Metoprolol can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Metoprolol.
EstroneThe serum concentration of Metoprolol can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Metoprolol.
Etacrynic acidThe risk or severity of adverse effects can be increased when Metoprolol is combined with Etacrynic acid.
EtanerceptEtanercept may decrease the antihypertensive activities of Metoprolol.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Metoprolol.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Metoprolol.
EtodolacEtodolac may decrease the antihypertensive activities of Metoprolol.
EtofenamateEtofenamate may decrease the antihypertensive activities of Metoprolol.
EtomidateEtomidate may increase the atrioventricular blocking (AV block) activities of Metoprolol.
EtoperidoneThe serum concentration of Metoprolol can be increased when it is combined with Etoperidone.
EtoposideThe serum concentration of Metoprolol can be increased when it is combined with Etoposide.
EtoricoxibEtoricoxib may decrease the antihypertensive activities of Metoprolol.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Metoprolol.
EtravirineThe serum concentration of Metoprolol can be increased when it is combined with Etravirine.
Evening primrose oilEvening primrose oil may decrease the antihypertensive activities of Metoprolol.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Metoprolol.
exisulindexisulind may decrease the antihypertensive activities of Metoprolol.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Metoprolol.
FelodipineMetoprolol may increase the hypotensive activities of Felodipine.
FenbufenFenbufen may decrease the antihypertensive activities of Metoprolol.
FenfluramineThe serum concentration of Metoprolol can be increased when it is combined with Fenfluramine.
FenoldopamMetoprolol may increase the hypotensive activities of Fenoldopam.
FenoprofenFenoprofen may decrease the antihypertensive activities of Metoprolol.
FenoterolMetoprolol may decrease the bronchodilatory activities of Fenoterol.
FentanylThe serum concentration of Metoprolol can be increased when it is combined with Fentanyl.
FenthionFenthion may increase the bradycardic activities of Metoprolol.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Metoprolol.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Metoprolol.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Metoprolol.
FingolimodMetoprolol may increase the bradycardic activities of Fingolimod.
FlecainideThe serum concentration of Metoprolol can be increased when it is combined with Flecainide.
FlecainideThe metabolism of Flecainide can be decreased when combined with Metoprolol.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Metoprolol.
FluconazoleThe serum concentration of Metoprolol can be increased when it is combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Metoprolol.
FlunixinFlunixin may decrease the antihypertensive activities of Metoprolol.
FluoxetineThe serum concentration of Metoprolol can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Metoprolol.
FlupentixolThe serum concentration of Metoprolol can be increased when it is combined with Flupentixol.
FluphenazineFluphenazine may increase the hypotensive activities of Metoprolol.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Metoprolol.
FlurazepamThe serum concentration of Metoprolol can be increased when it is combined with Flurazepam.
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Metoprolol.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Metoprolol.
FluvastatinThe serum concentration of Metoprolol can be increased when it is combined with Fluvastatin.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Metoprolol.
FluvoxamineThe serum concentration of Metoprolol can be increased when it is combined with Fluvoxamine.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Metoprolol.
FormoterolThe metabolism of Formoterol can be decreased when combined with Metoprolol.
FosinoprilMetoprolol may increase the hypotensive activities of Fosinopril.
FosphenytoinThe metabolism of Metoprolol can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypotensive activities of Metoprolol.
FurosemideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Furosemide.
GalantamineGalantamine may increase the bradycardic activities of Metoprolol.
Gallamine TriethiodideGallamine Triethiodide may increase the bradycardic activities of Metoprolol.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Metoprolol.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Metoprolol.
GemfibrozilThe metabolism of Metoprolol can be decreased when combined with Gemfibrozil.
GenisteinThe serum concentration of Metoprolol can be increased when it is combined with Genistein.
Ginkgo bilobaGinkgo biloba may increase the bradycardic activities of Metoprolol.
GlibornurideMetoprolol may increase the hypoglycemic activities of Glibornuride.
GliclazideMetoprolol may increase the hypoglycemic activities of Gliclazide.
GlimepirideMetoprolol may increase the hypoglycemic activities of Glimepiride.
GlipizideMetoprolol may increase the hypoglycemic activities of Glipizide.
GliquidoneMetoprolol may increase the hypoglycemic activities of Gliquidone.
GlisoxepideMetoprolol may increase the hypoglycemic activities of Glisoxepide.
GlyburideMetoprolol may increase the hypoglycemic activities of Glyburide.
GlyburideThe serum concentration of Metoprolol can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Metoprolol can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Metoprolol can be increased when it is combined with Gramicidin D.
GranisetronThe serum concentration of Metoprolol can be increased when it is combined with Granisetron.
GranisetronThe metabolism of Granisetron can be decreased when combined with Metoprolol.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Metoprolol.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Metoprolol.
GTS-21The risk or severity of adverse effects can be increased when Metoprolol is combined with GTS-21.
GuanabenzMetoprolol may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Metoprolol.
GuanethidineMetoprolol may increase the hypotensive activities of Guanethidine.
GuanfacineMetoprolol may increase the hypotensive activities of Guanfacine.
HalofantrineThe serum concentration of Metoprolol can be increased when it is combined with Halofantrine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Metoprolol.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Metoprolol.
HalothaneThe metabolism of Halothane can be decreased when combined with Metoprolol.
HexamethoniumMetoprolol may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the hypotensive activities of Metoprolol.
Histamine PhosphateThe serum concentration of Metoprolol can be increased when it is combined with Histamine Phosphate.
HMPL-004HMPL-004 may decrease the antihypertensive activities of Metoprolol.
Huperzine AHuperzine A may increase the bradycardic activities of Metoprolol.
HydracarbazineHydracarbazine may increase the hypotensive activities of Metoprolol.
HydralazineMetoprolol may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideMetoprolol may increase the hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Metoprolol.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Metoprolol.
HydroflumethiazideMetoprolol may increase the hypotensive activities of Hydroflumethiazide.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Metoprolol.
HydroxychloroquineThe metabolism of Metoprolol can be decreased when combined with Hydroxychloroquine.
HydroxyureaThe serum concentration of Metoprolol can be increased when it is combined with Hydroxyurea.
HydroxyzineThe serum concentration of Metoprolol can be increased when it is combined with Hydroxyzine.
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Metoprolol.
IbuprofenIbuprofen may decrease the antihypertensive activities of Metoprolol.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Metoprolol.
IbuproxamIbuproxam may decrease the antihypertensive activities of Metoprolol.
IcatibantIcatibant may decrease the antihypertensive activities of Metoprolol.
IdarubicinThe serum concentration of Metoprolol can be increased when it is combined with Idarubicin.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Metoprolol.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Metoprolol.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Metoprolol.
IloprostIloprost may increase the hypotensive activities of Metoprolol.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Metoprolol.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Metoprolol.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Metoprolol.
IndalpineThe serum concentration of Metoprolol can be increased when it is combined with Indalpine.
IndapamideMetoprolol may increase the hypotensive activities of Indapamide.
IndenololMetoprolol may increase the hypotensive activities of Indenolol.
IndinavirThe serum concentration of Metoprolol can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Metoprolol.
indisulamThe serum concentration of Metoprolol can be increased when it is combined with indisulam.
IndomethacinIndomethacin may decrease the antihypertensive activities of Metoprolol.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Metoprolol.
IndoprofenIndoprofen may decrease the antihypertensive activities of Metoprolol.
IndoraminMetoprolol may increase the hypotensive activities of Indoramin.
Insulin PorkMetoprolol may increase the hypoglycemic activities of Insulin Pork.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Metoprolol.
IproclozideIproclozide may increase the hypotensive activities of Metoprolol.
IproniazidIproniazid may increase the hypotensive activities of Metoprolol.
IrbesartanMetoprolol may increase the hypotensive activities of Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Metoprolol.
IsavuconazoniumThe serum concentration of Metoprolol can be increased when it is combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Metoprolol.
IsoetarineMetoprolol may decrease the bronchodilatory activities of Isoetarine.
IsoflurophateIsoflurophate may increase the bradycardic activities of Metoprolol.
IsoniazidThe metabolism of Metoprolol can be decreased when combined with Isoniazid.
IsoprenalineMetoprolol may decrease the bronchodilatory activities of Isoprenaline.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Metoprolol is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Metoprolol is combined with Isosorbide Mononitrate.
IsoxicamIsoxicam may decrease the antihypertensive activities of Metoprolol.
IsoxsuprineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Isoxsuprine.
IsradipineMetoprolol may increase the hypotensive activities of Isradipine.
ItraconazoleThe serum concentration of Metoprolol can be increased when it is combined with Itraconazole.
IvabradineMetoprolol may increase the bradycardic activities of Ivabradine.
IvacaftorThe serum concentration of Metoprolol can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Metoprolol.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Metoprolol.
KebuzoneKebuzone may decrease the antihypertensive activities of Metoprolol.
KetamineThe serum concentration of Metoprolol can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Metoprolol.
KetoconazoleThe serum concentration of Metoprolol can be increased when it is combined with Ketoconazole.
KetoprofenKetoprofen may decrease the antihypertensive activities of Metoprolol.
KetorolacKetorolac may decrease the antihypertensive activities of Metoprolol.
LabetalolMetoprolol may increase the hypotensive activities of Labetalol.
LacidipineMetoprolol may increase the hypotensive activities of Lacidipine.
LacosamideMetoprolol may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Metoprolol.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Metoprolol.
LanreotideMetoprolol may increase the bradycardic activities of Lanreotide.
LansoprazoleThe serum concentration of Metoprolol can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Metoprolol can be increased when it is combined with Lapatinib.
LatanoprostMetoprolol may increase the hypotensive activities of Latanoprost.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Metoprolol.
LeflunomideLeflunomide may decrease the antihypertensive activities of Metoprolol.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Metoprolol.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Metoprolol.
LercanidipineLercanidipine may increase the hypotensive activities of Metoprolol.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Metoprolol.
LevobunololThe risk or severity of adverse effects can be increased when Metoprolol is combined with Levobunolol.
LevodopaMetoprolol may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Metoprolol.
LevomilnacipranThe serum concentration of Metoprolol can be increased when it is combined with Levomilnacipran.
LevothyroxineThe serum concentration of Metoprolol can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Metoprolol.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Metoprolol.
LiothyronineThe serum concentration of Metoprolol can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Metoprolol can be decreased when it is combined with Liotrix.
LisinoprilMetoprolol may increase the hypotensive activities of Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Metoprolol.
LobelineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Lobeline.
LofexidineMetoprolol may increase the hypotensive activities of Lofexidine.
LomitapideThe serum concentration of Metoprolol can be increased when it is combined with Lomitapide.
LomustineThe serum concentration of Metoprolol can be increased when it is combined with Lomustine.
LomustineThe metabolism of Lomustine can be decreased when combined with Metoprolol.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Metoprolol.
LopinavirThe serum concentration of Metoprolol can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Metoprolol can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Metoprolol.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Metoprolol.
LornoxicamLornoxicam may decrease the antihypertensive activities of Metoprolol.
LosartanMetoprolol may increase the hypotensive activities of Losartan.
LovastatinThe serum concentration of Metoprolol can be increased when it is combined with Lovastatin.
LoxoprofenLoxoprofen may decrease the antihypertensive activities of Metoprolol.
Lu AA21004The serum concentration of Metoprolol can be increased when it is combined with Lu AA21004.
LucinactantMetoprolol may increase the bradycardic activities of Lucinactant.
LuliconazoleThe serum concentration of Metoprolol can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Metoprolol can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Metoprolol can be decreased when combined with Lumefantrine.
LumiracoxibLumiracoxib may decrease the antihypertensive activities of Metoprolol.
MacitentanMetoprolol may increase the hypotensive activities of Macitentan.
Magnesium salicylateMagnesium salicylate may decrease the antihypertensive activities of Metoprolol.
MalathionMalathion may increase the bradycardic activities of Metoprolol.
ManidipineMetoprolol may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Metoprolol is combined with Mannitol.
MaprotilineThe serum concentration of Metoprolol can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Metoprolol.
MasoprocolMasoprocol may decrease the antihypertensive activities of Metoprolol.
MebanazineMebanazine may increase the hypotensive activities of Metoprolol.
MebendazoleThe serum concentration of Metoprolol can be increased when it is combined with Mebendazole.
MecamylamineMetoprolol may increase the hypotensive activities of Mecamylamine.
Meclofenamic acidMeclofenamic acid may decrease the antihypertensive activities of Metoprolol.
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Metoprolol.
MefloquineMefloquine may increase the bradycardic activities of Metoprolol.
Megestrol acetateThe serum concentration of Metoprolol can be increased when it is combined with Megestrol acetate.
MeloxicamMeloxicam may decrease the antihypertensive activities of Metoprolol.
MemantineMemantine may increase the bradycardic activities of Metoprolol.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Metoprolol.
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Metoprolol.
MeprobamateThe serum concentration of Metoprolol can be increased when it is combined with Meprobamate.
MepyramineThe serum concentration of Metoprolol can be increased when it is combined with Mepyramine.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Metoprolol.
MesalazineMesalazine may decrease the antihypertensive activities of Metoprolol.
MesoridazineMesoridazine may increase the hypotensive activities of Metoprolol.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Metoprolol.
MetamizoleMetamizole may decrease the antihypertensive activities of Metoprolol.
MethacholineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Methacholine.
MethadoneThe serum concentration of Metoprolol can be increased when it is combined with Methadone.
MethadoneThe metabolism of Methadone can be decreased when combined with Metoprolol.
MethamphetamineThe serum concentration of Metoprolol can be increased when it is combined with Methamphetamine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Metoprolol.
MethazolamideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Methazolamide.
MethimazoleThe serum concentration of Metoprolol can be increased when it is combined with Methimazole.
MethohexitalMethohexital may increase the hypotensive activities of Metoprolol.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Metoprolol.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Metoprolol.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Metoprolol.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Metoprolol.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Metoprolol.
MethyldopaMetoprolol may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Metoprolol.
MethylnaltrexoneThe serum concentration of Metoprolol can be increased when it is combined with Methylnaltrexone.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Metoprolol.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Metoprolol.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Metoprolol.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Metoprolol.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Metoprolol.
MetipranololMetoprolol may increase the hypotensive activities of Metipranolol.
MetoclopramideThe serum concentration of Metoprolol can be increased when it is combined with Metoclopramide.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Metoprolol.
MetolazoneMetoprolol may increase the hypotensive activities of Metolazone.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Metoprolol.
MianserinThe serum concentration of Metoprolol can be increased when it is combined with Mianserin.
MianserinThe metabolism of Mianserin can be decreased when combined with Metoprolol.
MibefradilMetoprolol may increase the hypotensive activities of Mibefradil.
MiconazoleThe serum concentration of Metoprolol can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Metoprolol can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Metoprolol.
MidodrineMetoprolol may increase the bradycardic activities of Midodrine.
MidodrineThe serum concentration of Metoprolol can be increased when it is combined with Midodrine.
MifepristoneThe serum concentration of Metoprolol can be decreased when it is combined with Mifepristone.
MilnacipranThe serum concentration of Metoprolol can be increased when it is combined with Milnacipran.
MinaprineMinaprine may increase the bradycardic activities of Metoprolol.
MinaprineThe metabolism of Minaprine can be decreased when combined with Metoprolol.
MinoxidilMetoprolol may increase the hypotensive activities of Minoxidil.
MirabegronMirabegron may decrease the antihypertensive activities of Metoprolol.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Metoprolol.
MirtazapineThe serum concentration of Metoprolol can be increased when it is combined with Mirtazapine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Metoprolol.
MitomycinThe serum concentration of Metoprolol can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Metoprolol can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Metoprolol.
MoclobemideMoclobemide may increase the hypotensive activities of Metoprolol.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Metoprolol.
ModafinilThe metabolism of Metoprolol can be decreased when combined with Modafinil.
MoexiprilMetoprolol may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Metoprolol.
MoricizineMoricizine may increase the hypotensive activities of Metoprolol.
MorphineThe serum concentration of Morphine can be increased when it is combined with Metoprolol.
MoxonidineMetoprolol may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilMycophenolate mofetil may decrease the antihypertensive activities of Metoprolol.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Metoprolol.
Mycophenolic acidMycophenolic acid may decrease the antihypertensive activities of Metoprolol.
NabumetoneNabumetone may decrease the antihypertensive activities of Metoprolol.
NadololMetoprolol may increase the hypotensive activities of Nadolol.
NaftifineNaftifine may decrease the antihypertensive activities of Metoprolol.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Metoprolol.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Metoprolol.
NaltrexoneThe serum concentration of Metoprolol can be increased when it is combined with Naltrexone.
NaphazolineNaphazoline may increase the atrioventricular blocking (AV block) activities of Metoprolol.
NaproxenNaproxen may decrease the antihypertensive activities of Metoprolol.
NaringeninThe serum concentration of Metoprolol can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Metoprolol.
NCX 4016NCX 4016 may decrease the antihypertensive activities of Metoprolol.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Metoprolol.
NebivololNebivolol may increase the hypotensive activities of Metoprolol.
NefazodoneThe serum concentration of Metoprolol can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Metoprolol.
NelfinavirThe serum concentration of Metoprolol can be decreased when it is combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Metoprolol.
NeostigmineNeostigmine may increase the bradycardic activities of Metoprolol.
NepafenacNepafenac may decrease the antihypertensive activities of Metoprolol.
NesiritideThe risk or severity of adverse effects can be increased when Metoprolol is combined with Nesiritide.
NetupitantThe metabolism of Netupitant can be decreased when combined with Metoprolol.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Metoprolol.
NiacinThe serum concentration of Metoprolol can be increased when it is combined with Niacin.
NialamideNialamide may increase the hypotensive activities of Metoprolol.
NicardipineMetoprolol may increase the hypotensive activities of Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Metoprolol.
NicorandilNicorandil may increase the hypotensive activities of Metoprolol.
NicotinamideThe serum concentration of Metoprolol can be increased when it is combined with Nicotinamide.
NicotineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Nicotine.
Nicotine bitartrateThe risk or severity of adverse effects can be increased when Metoprolol is combined with Nicotine bitartrate.
NifedipineNifedipine may increase the hypotensive activities of Metoprolol.
NifedipineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Nifedipine.
Niflumic AcidNiflumic Acid may decrease the antihypertensive activities of Metoprolol.
NiguldipineMetoprolol may increase the hypotensive activities of Niguldipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Metoprolol.
NilvadipineMetoprolol may increase the hypotensive activities of Nilvadipine.
NimesulideNimesulide may decrease the antihypertensive activities of Metoprolol.
NimodipineMetoprolol may increase the hypotensive activities of Nimodipine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Metoprolol.
NisoldipineMetoprolol may increase the hypotensive activities of Nisoldipine.
NitrazepamThe serum concentration of Metoprolol can be increased when it is combined with Nitrazepam.
NitrendipineMetoprolol may increase the hypotensive activities of Nitrendipine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Metoprolol.
NitroglycerinThe risk or severity of adverse effects can be increased when Metoprolol is combined with Nitroglycerin.
NitroprussideMetoprolol may increase the hypotensive activities of Nitroprusside.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Metoprolol.
NorepinephrineNorepinephrine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
NorepinephrineMetoprolol may decrease the bronchodilatory activities of Norepinephrine.
NorethisteroneThe serum concentration of Metoprolol can be decreased when it is combined with Norethisterone.
NortriptylineThe serum concentration of Metoprolol can be increased when it is combined with Nortriptyline.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Metoprolol.
ObinutuzumabMetoprolol may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Metoprolol.
OctreotideOctreotide may increase the bradycardic activities of Metoprolol.
OlanzapineThe serum concentration of Metoprolol can be increased when it is combined with Olanzapine.
OlmesartanMetoprolol may increase the hypotensive activities of Olmesartan.
OlodaterolMetoprolol may decrease the bronchodilatory activities of Olodaterol.
OlopatadineOlopatadine may decrease the antihypertensive activities of Metoprolol.
OlsalazineOlsalazine may decrease the antihypertensive activities of Metoprolol.
OmapatrilatMetoprolol may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Metoprolol.
OmeprazoleThe serum concentration of Metoprolol can be increased when it is combined with Omeprazole.
OndansetronThe serum concentration of Metoprolol can be increased when it is combined with Ondansetron.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Metoprolol.
OrciprenalineMetoprolol may decrease the bronchodilatory activities of Orciprenaline.
OrgoteinOrgotein may decrease the antihypertensive activities of Metoprolol.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Metoprolol.
OuabainMetoprolol may increase the bradycardic activities of Ouabain.
OxamniquineThe serum concentration of Metoprolol can be increased when it is combined with Oxamniquine.
OxaprozinOxaprozin may decrease the antihypertensive activities of Metoprolol.
OxprenololMetoprolol may increase the hypotensive activities of Oxprenolol.
OxybutyninThe serum concentration of Metoprolol can be increased when it is combined with Oxybutynin.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Metoprolol.
OxymetazolineOxymetazoline may increase the atrioventricular blocking (AV block) activities of Metoprolol.
OxymetholoneThe serum concentration of Metoprolol can be increased when it is combined with Oxymetholone.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Metoprolol.
OxyphenbutazoneOxyphenbutazone may decrease the antihypertensive activities of Metoprolol.
P-NitrophenolThe serum concentration of Metoprolol can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Metoprolol can be increased when it is combined with Paclitaxel.
PaliperidonePaliperidone may increase the atrioventricular blocking (AV block) activities of Metoprolol.
Palmitic AcidThe serum concentration of Metoprolol can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Metoprolol.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Metoprolol.
PanobinostatThe metabolism of Metoprolol can be decreased when combined with Panobinostat.
PantoprazoleThe serum concentration of Metoprolol can be increased when it is combined with Pantoprazole.
PapaverineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Papaverine.
ParecoxibParecoxib may decrease the antihypertensive activities of Metoprolol.
PargylineMetoprolol may increase the hypotensive activities of Pargyline.
ParoxetineThe serum concentration of Metoprolol can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Metoprolol.
PasireotideMetoprolol may increase the bradycardic activities of Pasireotide.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Metoprolol.
Peginterferon alfa-2bThe serum concentration of Metoprolol can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololMetoprolol may increase the hypotensive activities of Penbutolol.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Metoprolol.
PentobarbitalPentobarbital may increase the hypotensive activities of Metoprolol.
PentoliniumMetoprolol may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Metoprolol.
PergolideThe serum concentration of Metoprolol can be increased when it is combined with Pergolide.
PerhexilineThe serum concentration of Metoprolol can be increased when it is combined with Perhexiline.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Metoprolol.
PerindoprilMetoprolol may increase the hypotensive activities of Perindopril.
PerphenazinePerphenazine may increase the hypotensive activities of Metoprolol.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Metoprolol.
PethidineThe metabolism of Pethidine can be decreased when combined with Metoprolol.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Metoprolol.
PhenelzinePhenelzine may increase the hypotensive activities of Metoprolol.
PhenforminThe metabolism of Phenformin can be decreased when combined with Metoprolol.
PheniprazinePheniprazine may increase the hypotensive activities of Metoprolol.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Metoprolol.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Metoprolol.
PhenoxybenzamineMetoprolol may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Metoprolol.
PhentermineThe serum concentration of Metoprolol can be increased when it is combined with Phentermine.
PhentolamineMetoprolol may increase the hypotensive activities of Phentolamine.
PhenylbutazonePhenylbutazone may decrease the antihypertensive activities of Metoprolol.
PhenylpropanolaminePhenylpropanolamine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
PhenylpropanolamineMetoprolol may decrease the bronchodilatory activities of Phenylpropanolamine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Metoprolol.
PhenytoinThe metabolism of Metoprolol can be increased when combined with Phenytoin.
PhysostigminePhysostigmine may increase the bradycardic activities of Metoprolol.
PilocarpineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Pilocarpine.
PimecrolimusPimecrolimus may decrease the antihypertensive activities of Metoprolol.
PimozideThe serum concentration of Metoprolol can be increased when it is combined with Pimozide.
PinacidilMetoprolol may increase the hypotensive activities of Pinacidil.
PindololMetoprolol may increase the hypotensive activities of Pindolol.
PioglitazoneThe serum concentration of Metoprolol can be increased when it is combined with Pioglitazone.
PiperazineThe metabolism of Piperazine can be decreased when combined with Metoprolol.
PipotiazineThe serum concentration of Metoprolol can be increased when it is combined with Pipotiazine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Metoprolol.
PirbuterolMetoprolol may decrease the bronchodilatory activities of Pirbuterol.
PirfenidonePirfenidone may decrease the antihypertensive activities of Metoprolol.
PirlindolePirlindole may increase the hypotensive activities of Metoprolol.
PiroxicamPiroxicam may decrease the antihypertensive activities of Metoprolol.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Metoprolol.
PivhydrazinePivhydrazine may increase the hypotensive activities of Metoprolol.
Platelet Activating FactorThe serum concentration of Metoprolol can be decreased when it is combined with Platelet Activating Factor.
PolythiazideMetoprolol may increase the hypotensive activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Metoprolol.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Metoprolol.
Poractant alfaMetoprolol may increase the bradycardic activities of Poractant alfa.
PosaconazoleThe serum concentration of Metoprolol can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Metoprolol.
PraziquantelThe serum concentration of Metoprolol can be increased when it is combined with Praziquantel.
PrazosinMetoprolol may increase the hypotensive activities of Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Metoprolol.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Metoprolol.
PrimaquineThe metabolism of Metoprolol can be decreased when combined with Primaquine.
PrimidonePrimidone may increase the hypotensive activities of Metoprolol.
ProbenecidThe serum concentration of Metoprolol can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Metoprolol.
ProcaterolMetoprolol may decrease the bronchodilatory activities of Procaterol.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Metoprolol.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Metoprolol.
ProgesteroneThe serum concentration of Metoprolol can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Metoprolol.
ProguanilThe serum concentration of Metoprolol can be increased when it is combined with Proguanil.
PromazinePromazine may increase the hypotensive activities of Metoprolol.
PromethazinePromethazine may increase the hypotensive activities of Metoprolol.
PromethazineThe metabolism of Promethazine can be decreased when combined with Metoprolol.
PropacetamolPropacetamol may decrease the antihypertensive activities of Metoprolol.
PropafenoneThe serum concentration of Metoprolol can be increased when it is combined with Propafenone.
PropafenoneMetoprolol may increase the bradycardic activities of Propafenone.
PropofolThe serum concentration of Metoprolol can be increased when it is combined with Propofol.
PropofolThe metabolism of Propofol can be decreased when combined with Metoprolol.
PropranololMetoprolol may increase the hypotensive activities of Propranolol.
ProtriptylineThe serum concentration of Metoprolol can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Metoprolol.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Metoprolol.
PseudoephedrinePseudoephedrine may increase the atrioventricular blocking (AV block) activities of Metoprolol.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Metoprolol.
PTC299PTC299 may decrease the antihypertensive activities of Metoprolol.
PyridostigminePyridostigmine may increase the bradycardic activities of Metoprolol.
PyrimethamineThe serum concentration of Metoprolol can be increased when it is combined with Pyrimethamine.
QuercetinThe serum concentration of Metoprolol can be increased when it is combined with Quercetin.
QuetiapineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Quetiapine.
QuinacrineThe serum concentration of Metoprolol can be increased when it is combined with Quinacrine.
QuinaprilMetoprolol may increase the hypotensive activities of Quinapril.
QuinidineThe serum concentration of Metoprolol can be increased when it is combined with Quinidine.
QuinineQuinine may increase the hypotensive activities of Metoprolol.
QuinineThe serum concentration of Quinine can be increased when it is combined with Metoprolol.
RabeprazoleThe serum concentration of Metoprolol can be increased when it is combined with Rabeprazole.
RamiprilRamipril may increase the hypotensive activities of Metoprolol.
RanitidineThe serum concentration of Metoprolol can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Metoprolol.
RasagilineRasagiline may increase the hypotensive activities of Metoprolol.
ReboxetineThe serum concentration of Metoprolol can be increased when it is combined with Reboxetine.
RegorafenibRegorafenib may increase the bradycardic activities of Metoprolol.
RemikirenRemikiren may increase the hypotensive activities of Metoprolol.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Metoprolol.
repinotanThe metabolism of repinotan can be decreased when combined with Metoprolol.
RescinnamineMetoprolol may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Metoprolol.
ResveratrolResveratrol may decrease the antihypertensive activities of Metoprolol.
RifampicinThe serum concentration of Metoprolol can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Metoprolol.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Metoprolol.
RilpivirineThe serum concentration of Metoprolol can be increased when it is combined with Rilpivirine.
RiociguatMetoprolol may increase the hypotensive activities of Riociguat.
RisperidoneMetoprolol may increase the hypotensive activities of Risperidone.
RisperidoneThe serum concentration of Metoprolol can be increased when it is combined with Risperidone.
RitodrineMetoprolol may decrease the bronchodilatory activities of Ritodrine.
RitonavirThe serum concentration of Metoprolol can be decreased when it is combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Metoprolol.
RituximabMetoprolol may increase the hypotensive activities of Rituximab.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Metoprolol.
RivastigmineRivastigmine may increase the bradycardic activities of Metoprolol.
RofecoxibRofecoxib may decrease the antihypertensive activities of Metoprolol.
RolapitantThe serum concentration of Metoprolol can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Metoprolol.
RopiniroleThe metabolism of Metoprolol can be decreased when combined with Ropinirole.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Metoprolol.
RosiglitazoneThe serum concentration of Metoprolol can be increased when it is combined with Rosiglitazone.
RotigotineThe serum concentration of Metoprolol can be increased when it is combined with Rotigotine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Metoprolol.
RutinThe serum concentration of Metoprolol can be increased when it is combined with Rutin.
RuxolitinibRuxolitinib may increase the bradycardic activities of Metoprolol.
SafrazineSafrazine may increase the hypotensive activities of Metoprolol.
SalbutamolMetoprolol may decrease the bronchodilatory activities of Salbutamol.
SalicylamideSalicylamide may decrease the antihypertensive activities of Metoprolol.
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Metoprolol.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Metoprolol.
SalmeterolMetoprolol may decrease the bronchodilatory activities of Salmeterol.
SalsalateSalsalate may decrease the antihypertensive activities of Metoprolol.
SaprisartanMetoprolol may increase the hypotensive activities of Saprisartan.
SaquinavirThe serum concentration of Metoprolol can be decreased when it is combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Metoprolol.
ScopolamineThe serum concentration of Metoprolol can be increased when it is combined with Scopolamine.
SecobarbitalSecobarbital may increase the hypotensive activities of Metoprolol.
SelegilineSelegiline may increase the hypotensive activities of Metoprolol.
SelexipagMetoprolol may increase the hypotensive activities of Selexipag.
SeratrodastSeratrodast may decrease the antihypertensive activities of Metoprolol.
SertindoleThe metabolism of Sertindole can be decreased when combined with Metoprolol.
SertralineThe serum concentration of Metoprolol can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Metoprolol.
SildenafilSildenafil may increase the antihypertensive activities of Metoprolol.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Metoprolol.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Metoprolol.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Metoprolol.
SimvastatinThe serum concentration of Metoprolol can be increased when it is combined with Simvastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Metoprolol.
SirolimusThe serum concentration of Metoprolol can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Metoprolol.
SitaxentanMetoprolol may increase the hypotensive activities of Sitaxentan.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Metoprolol.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Metoprolol.
SotalolThe risk or severity of adverse effects can be increased when Metoprolol is combined with Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Metoprolol.
SparteineThe serum concentration of Metoprolol can be increased when it is combined with Sparteine.
SparteineThe metabolism of Sparteine can be decreased when combined with Metoprolol.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Metoprolol.
SpiraprilMetoprolol may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Metoprolol is combined with Spironolactone.
SRT501SRT501 may decrease the antihypertensive activities of Metoprolol.
St. John's WortThe serum concentration of Metoprolol can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Metoprolol can be increased when it is combined with Staurosporine.
StiripentolThe metabolism of Metoprolol can be decreased when combined with Stiripentol.
StreptozocinThe serum concentration of Metoprolol can be decreased when it is combined with Streptozocin.
SufentanilMetoprolol may increase the bradycardic activities of Sufentanil.
SulfanilamideThe serum concentration of Metoprolol can be increased when it is combined with Sulfanilamide.
SulfaphenazoleThe serum concentration of Metoprolol can be increased when it is combined with Sulfaphenazole.
SulfasalazineSulfasalazine may decrease the antihypertensive activities of Metoprolol.
SulfinpyrazoneThe serum concentration of Metoprolol can be increased when it is combined with Sulfinpyrazone.
SulindacSulindac may decrease the antihypertensive activities of Metoprolol.
SumatriptanThe serum concentration of Metoprolol can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Metoprolol can be increased when it is combined with Sunitinib.
SuprofenSuprofen may decrease the antihypertensive activities of Metoprolol.
TacrineTacrine may increase the bradycardic activities of Metoprolol.
TacrolimusThe serum concentration of Metoprolol can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Metoprolol.
TadalafilTadalafil may increase the antihypertensive activities of Metoprolol.
TamoxifenThe serum concentration of Metoprolol can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Metoprolol.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Metoprolol.
TapentadolThe serum concentration of Metoprolol can be increased when it is combined with Tapentadol.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Metoprolol.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Metoprolol.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Metoprolol.
TegaserodThe serum concentration of Metoprolol can be increased when it is combined with Tegaserod.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Metoprolol.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Metoprolol.
TelithromycinThe serum concentration of Metoprolol can be increased when it is combined with Telithromycin.
TelmisartanMetoprolol may increase the hypotensive activities of Telmisartan.
TemocaprilMetoprolol may increase the hypotensive activities of Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Metoprolol.
TenoxicamTenoxicam may decrease the antihypertensive activities of Metoprolol.
TepoxalinTepoxalin may decrease the antihypertensive activities of Metoprolol.
TerazosinThe risk or severity of adverse effects can be increased when Metoprolol is combined with Terazosin.
TerbinafineThe serum concentration of Metoprolol can be increased when it is combined with Terbinafine.
TerbutalineMetoprolol may decrease the bronchodilatory activities of Terbutaline.
TerfenadineThe serum concentration of Metoprolol can be increased when it is combined with Terfenadine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Metoprolol.
TeriflunomideTeriflunomide may decrease the antihypertensive activities of Metoprolol.
TerlipressinMetoprolol may increase the hypotensive activities of Terlipressin.
TesmilifeneThe serum concentration of Metoprolol can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Metoprolol.
TestosteroneThe serum concentration of Metoprolol can be increased when it is combined with Testosterone.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Metoprolol.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Metoprolol.
ThiamylalThiamylal may increase the hypotensive activities of Metoprolol.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Metoprolol.
ThiopentalThiopental may increase the hypotensive activities of Metoprolol.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Metoprolol.
ThioridazineThioridazine may increase the hypotensive activities of Metoprolol.
ThiothixeneThe serum concentration of Metoprolol can be increased when it is combined with Thiothixene.
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Metoprolol.
TiboloneMetoprolol may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Metoprolol.
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Metoprolol.
TicrynafenMetoprolol may increase the hypotensive activities of Ticrynafen.
TimololMetoprolol may increase the hypotensive activities of Timolol.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Metoprolol.
TipranavirThe serum concentration of Metoprolol can be increased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Metoprolol.
TizanidineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Tizanidine.
TofacitinibTofacitinib may increase the bradycardic activities of Metoprolol.
TolazamideMetoprolol may increase the hypoglycemic activities of Tolazamide.
TolazolineMetoprolol may increase the hypotensive activities of Tolazoline.
TolbutamideMetoprolol may increase the hypoglycemic activities of Tolbutamide.
Tolfenamic AcidTolfenamic Acid may decrease the antihypertensive activities of Metoprolol.
TolmetinTolmetin may decrease the antihypertensive activities of Metoprolol.
ToloxatoneToloxatone may increase the hypotensive activities of Metoprolol.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Metoprolol.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Metoprolol.
TopiramateThe metabolism of Metoprolol can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Metoprolol.
TorasemideTorasemide may increase the hypotensive activities of Metoprolol.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Metoprolol.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Metoprolol.
TramadolThe serum concentration of Metoprolol can be increased when it is combined with Tramadol.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Metoprolol.
TrandolaprilMetoprolol may increase the hypotensive activities of Trandolapril.
TranilastTranilast may decrease the antihypertensive activities of Metoprolol.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Metoprolol.
TranylcypromineTranylcypromine may increase the hypotensive activities of Metoprolol.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Metoprolol.
TravoprostMetoprolol may increase the hypotensive activities of Travoprost.
TrazodoneThe serum concentration of Metoprolol can be increased when it is combined with Trazodone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Metoprolol.
TreprostinilMetoprolol may increase the hypotensive activities of Treprostinil.
TriamtereneThe risk or severity of adverse effects can be increased when Metoprolol is combined with Triamterene.
TrichlorfonTrichlorfon may increase the bradycardic activities of Metoprolol.
TrichlormethiazideMetoprolol may increase the hypotensive activities of Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Metoprolol.
TriflupromazineTriflupromazine may increase the hypotensive activities of Metoprolol.
TrimazosinMetoprolol may increase the hypotensive activities of Trimazosin.
TrimethaphanMetoprolol may increase the hypotensive activities of Trimethaphan.
TrimethoprimThe serum concentration of Metoprolol can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Metoprolol can be increased when it is combined with Trimipramine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Metoprolol.
TripelennamineThe serum concentration of Metoprolol can be increased when it is combined with Tripelennamine.
TriprolidineThe serum concentration of Metoprolol can be increased when it is combined with Triprolidine.
Trisalicylate-cholineTrisalicylate-choline may decrease the antihypertensive activities of Metoprolol.
TroleandomycinThe serum concentration of Metoprolol can be increased when it is combined with Troleandomycin.
TrospiumThe serum concentration of Metoprolol can be increased when it is combined with Trospium.
TubocurarineTubocurarine may increase the bradycardic activities of Metoprolol.
UdenafilUdenafil may increase the antihypertensive activities of Metoprolol.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Metoprolol.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Metoprolol.
UnoprostoneMetoprolol may increase the hypotensive activities of Unoprostone.
ValdecoxibValdecoxib may decrease the antihypertensive activities of Metoprolol.
ValsartanValsartan may increase the hypotensive activities of Metoprolol.
VardenafilVardenafil may increase the antihypertensive activities of Metoprolol.
VareniclineThe risk or severity of adverse effects can be increased when Metoprolol is combined with Varenicline.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Metoprolol.
VemurafenibThe serum concentration of Metoprolol can be increased when it is combined with Vemurafenib.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Metoprolol.
VerapamilThe risk or severity of adverse effects can be increased when Metoprolol is combined with Verapamil.
VilanterolMetoprolol may decrease the bronchodilatory activities of Vilanterol.
VilazodoneThe serum concentration of Metoprolol can be increased when it is combined with Vilazodone.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Metoprolol.
VinblastineThe serum concentration of Metoprolol can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Metoprolol.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Metoprolol.
VincristineThe serum concentration of Metoprolol can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Metoprolol can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Metoprolol.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Metoprolol.
VoriconazoleThe metabolism of Metoprolol can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Metoprolol can be increased when it is combined with Vortioxetine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Metoprolol.
XylometazolineMetoprolol may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Metoprolol.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Metoprolol.
ZafirlukastThe serum concentration of Metoprolol can be increased when it is combined with Zafirlukast.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Metoprolol.
ZaltoprofenZaltoprofen may decrease the antihypertensive activities of Metoprolol.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Metoprolol.
ZileutonZileuton may decrease the antihypertensive activities of Metoprolol.
ZimelidineThe serum concentration of Metoprolol can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Metoprolol can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Metoprolol.
ZomepiracZomepirac may decrease the antihypertensive activities of Metoprolol.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Metoprolol.
Food Interactions
  • Avoid alcohol.
  • Avoid natural licorice.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Schafer M, Frischkopf K, Taimor G, Piper HM, Schluter KD: Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. Am J Physiol Cell Physiol. 2000 Aug;279(2):C495-503. [PubMed:10913016 ]
  2. Staudt A, Mobini R, Fu M, Grosse Y, Stangl V, Stangl K, Thiele A, Baumann G, Felix SB: beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes. Eur J Pharmacol. 2001 Jul 6;423(2-3):115-9. [PubMed:11448474 ]
  3. Staudt Y, Mobini R, Fu M, Felix SB, Kuhn JP, Staudt A: Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. Eur J Pharmacol. 2003 Apr 11;466(1-2):1-6. [PubMed:12679135 ]
  4. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [PubMed:12844134 ]
  5. Liu J, Liu ZQ, Tan ZR, Chen XP, Wang LS, Zhou G, Zhou HH: Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther. 2003 Oct;74(4):372-9. [PubMed:14534524 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Zebrack JS, Munger M, Macgregor J, Lombardi WL, Stoddard GP, Gilbert EM: Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy. 2009 Aug;29(8):883-90. doi: 10.1592/phco.29.8.883. [PubMed:19637941 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Belpaire FM, Wijnant P, Temmerman A, Rasmussen BB, Brosen K: The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. Eur J Clin Pharmacol. 1998 May;54(3):261-4. [PubMed:9681670 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. [PubMed:10960071 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. [PubMed:11895100 ]
  2. Doppenschmitt S, Langguth P, Regardh CG, Andersson TB, Hilgendorf C, Spahn-Langguth H: Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay. J Pharmacol Exp Ther. 1999 Jan;288(1):348-57. [PubMed:9862789 ]
  3. Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. [PubMed:12948010 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23