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Displaying drugs 176 - 200 of 8922 in total
Asparaginase Escherichia coli
Asparaginase derived from Escherichia coli (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginase from E. coli has clinically shown to exhibit antitumor...
Approved
Investigational
Romidepsin
Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.
Approved
Investigational
Matched Iupac: … (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo …
Allantoin
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains...
Approved
Matched Synonyms: … (2,5-Dioxo-4-imidazolidinyl)urea ... 2,5-Dioxo-4-imidazolidinyl-urea ... 4-ureido-2,5-imidazolidinedione …
Matched Iupac: … (2,5-dioxoimidazolidin-4-yl)urea …
Matched Mixtures name: … Hands First 4 in 1 ... Mycellcare iT s …
Matched Products: … Miracle GYN (4 Tablets) ... Any Mi Natural Magic BB No.7 …
Matched Iupac: … (2,5-dioxoimidazolidin-4-yl)urea …
Matched Mixtures name: … Hands First 4 in 1 ... Mycellcare iT s …
Matched Products: … Miracle GYN (4 Tablets) ... Any Mi Natural Magic BB No.7 …
Tirofiban
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Approved
Matched Synonyms: … (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid ... N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine …
Matched Iupac: … (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid …
Matched Iupac: … (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid …
Apremilast
Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole.[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted...
Approved
Investigational
Matched Synonyms: … N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4- …
Matched Iupac: … N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl …
Matched Description: … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types …
Matched Categories: … Phosphodiesterase 4 Inhibitors …
Matched Iupac: … N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl …
Matched Description: … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types …
Matched Categories: … Phosphodiesterase 4 Inhibitors …
Benzocaine
Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Synonyms: … 4-aminobenzoic acid ethyl ester …
Matched Iupac: … ethyl 4-aminobenzoate …
Matched Mixtures name: … Coghlan s Sting Relief ... Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%. ... Adventure Medical Kits 1-4 Person First Aid …
Matched Products: … Max 4 Men - Max Control Male Sex Prolong Unscented ... Goyescas 7 Syrups Sore Throat Relief ... 7 Select Oral Pain Maximum Strength Relief …
Matched Iupac: … ethyl 4-aminobenzoate …
Matched Mixtures name: … Coghlan s Sting Relief ... Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%. ... Adventure Medical Kits 1-4 Person First Aid …
Matched Products: … Max 4 Men - Max Control Male Sex Prolong Unscented ... Goyescas 7 Syrups Sore Throat Relief ... 7 Select Oral Pain Maximum Strength Relief …
Dihydrostreptomycin
Dihydrostreptomycin is an aminoglycoside antibiotic. In humans, the use of dihydrostreptomycin has been associated with ototoxicity. The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate.
Approved
Investigational
Vet approved
Withdrawn
Matched Synonyms: … N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-a-L-glucopyranosyl]-3-C-(hydroxymethyl ... N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl ... N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl …
Matched Iupac: … N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl ... )-3-(methylamino)oxan-2-yl]oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl …
Matched Salts cas: … 5490-27-7 …
Matched Iupac: … N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl ... )-3-(methylamino)oxan-2-yl]oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl …
Matched Salts cas: … 5490-27-7 …
Codeine
The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Iupac: … -7(18),8,10,15-tetraen-14-ol ... (1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca …
Matched Salts cas: … 1422-07-7 ... 1420-53-7 …
Matched Mixtures name: … PACOFEN S TABLET 20 TABLET ... Fiorinal-C 1/4 ... Robaxisal C 1/4 …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Matched Salts cas: … 1422-07-7 ... 1420-53-7 …
Matched Mixtures name: … PACOFEN S TABLET 20 TABLET ... Fiorinal-C 1/4 ... Robaxisal C 1/4 …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Human Rho(D) immune globulin
Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Products: … Hyperrho S/d Full Dose ... Hyperrho S/d Mini-dose ... HYPERRHO S/D FULL DOSE …
Sodium ferric gluconate complex
Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography. It is composed of iron (III) oxide hydrate directly bonded to sucrose...
Approved
Matched Iupac: … diiron(3+) ion sodium pentakis((2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl …
Fluciclovine (18F)
Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging. The structure of fluciclovine allows it to be uptaken by the tumoral cells by its amino acid transporter without incorporating in the metabolism within the...
Approved
Pralatrexate
Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma . Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts. Compared to methotrexate, pralatrexate has better accumulation in cancer cells. Pralatrexate is designed to have...
Approved
Investigational
Matched Synonyms: … (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid ... N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid ... (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid …
Matched Iupac: … (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid …
Matched Iupac: … (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid …
Canagliflozin
Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label].
It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018...
Approved
Matched Iupac: … (2S,3R,4R,5S,6R)-2-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)-6-(hydroxymethyl)oxane …
Tamsulosin
Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.[Label] It is indicated for the treatment of signs and symptoms of benign prostatic hypertrophy.[Label] Antagonism of these receptors leads to relaxation of smooth muscle in...
Approved
Investigational
Matched Mixtures name: … DUODART 0,5 MG/0,4 MG KAPSÜL,7 KAPSÜL …
Sulfinpyrazone
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Approved
Matched Synonyms: … 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine ... 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione ... 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione …
Matched Iupac: … 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione …
Matched Iupac: … 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione …
Levoketoconazole
Cushing's syndrome (CS) is underpinned by chronic hypercortisolism leading to multisystem morbidity, including effects on the cardiovascular and endocrine systems, metabolic syndrome with accompanying changes in body composition, neuropsychiatric effects, changes in blood pressure and chemistry, and opportunistic infections.[A244078, A244083] Ketoconazole has been used both on- and off-label to treat...
Approved
Investigational
Matched Iupac: … 1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Synonyms: … 4-amino-10-methylfolic acid ... 4-amino-N(10)-methylpteroylglutamic acid ... N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Description: … [L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198] …
Matched Products: … METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 15 MG/1,5 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Description: … [L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198] …
Matched Products: … METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 15 MG/1,5 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Carbidopa
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with levodopa. An individual formulation containing solely carbidopa was generated to treat...
Approved
Matched Synonyms: … (S)-carbidopa ... (S)-(−)-carbidopa …
Matched Salts cas: … 38821-49-7 …
Matched Mixtures name: … DUODOPA 20 MG/ML + 5 MG/ML INTESTINAL JEL, 7 ADET …
Matched Salts cas: … 38821-49-7 …
Matched Mixtures name: … DUODOPA 20 MG/ML + 5 MG/ML INTESTINAL JEL, 7 ADET …
Selpercatinib
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including cabozantinib, ponatinib, sorafenib, sunitinib, and vandetanib, have shown efficacy in RET-driven cancers, their...
Approved
Investigational
Matched Synonyms: … 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3 …
Matched Iupac: … 6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3 …
Matched Iupac: … 6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3 …
Fluocinolone acetonide
Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetonide was developed by Taro...
Approved
Investigational
Vet approved
Matched Mixtures name: … Fluocinolone Acetonide 0.01% / Minoxidil 7% / Progesterone 0.1% ... Fluocinolone Acetonide 0.01/ Niacinamide 4 ... Fluocinolone Acetonide 0.01% / Niacinamide 4% …
Ramipril
Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Iupac: … (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[ …
Theophylline
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Sumatriptan
Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Salts cas: … 103628-48-4 …
Matched Products: … SUTRIP 100 MG TABLET, 4 ADET …
Matched Products: … SUTRIP 100 MG TABLET, 4 ADET …
Angiotensin II
Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.
As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Lumasiran
Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. Oxlumo, producted by...
Approved
Investigational
Matched Salts cas: … 1834612-06-4 …
Displaying drugs 176 - 200 of 8922 in total