Fatty Acids, Unsaturated

Name
Fatty Acids, Unsaturated
Accession Number
DBCAT000300
Description

FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.

Drugs
DrugDrug Description
alpha-Linolenic acidA polyunsaturated omega-3 fatty acid found in many supplements.
Dihomo-gamma-linolenic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
IcosapentA polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements.
TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
TreprostinilA prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
Carboprost tromethamineA prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective.
LatanoprostAn isopropyl ester prodrug used to treat increased intraocular pressure.
AlprostadilA medication used to treat erectile dysfunction.
BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DinoprostoneA prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.
MisoprostolA prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers.
LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
IloprostA synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
Dinoprost tromethamineUsed for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities...
EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
Prostaglandin B2Not Available
Ricinoleic AcidNot Available
Prostaglandin G2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
Oleic AcidA naturally occurring fatty acid with antibacterial properties added to a variety of drug products.
Palmitoleic AcidNot Available
Arachidonic AcidAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides....
Oleoyl-estroneFor the treatment of obesity.
BeraprostFor the treatment of pulmonary hypertension.
CobiprostoneInvestigated for use/treatment in cystic fibrosis.
Ethanolamine oleateA mild sclerosing agent used in the treatment of esophageal varices with recent bleeding episodes.
CapsaicinA topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.
UnoprostoneA prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents.
TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Leukotriene C4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates...
Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
GemeprostIndicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients...
ZucapsaicinA topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients.
LimaprostLimaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain...
Omega-3-acid ethyl estersA mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia.
Undecylenic acidAn antifungal used to treat tinea species infections.
Omega-3 fatty acidsAn ingredient found in a variety of supplements and vitamins.
Borage oilBorage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as...
NonivamideNonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , .
Evening primrose oilEvening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical...
FenprostaleneNot Annotated
LuprostiolNot Annotated
ProstaleneAnalog of prostaglandin F2 alpha.
CloprostenolNot Annotated
FluprostenolNot Annotated
Latanoprostene bunodA prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma.
Leukotriene D4Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis.
GefarnateGefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease.
SulprostoneSulprostone has been used in trials studying Abortion, Induced.
DinoprostA medication used to induce a second trimester abortion.
Leukotriene B4Leukotriene B4 has been used in trials studying the treatment of HIV Infections.
Resolvin E1Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers).
Omega-6 fatty acidsThere are no current pharmacotherapeutic products based on omega-6 fatty acids.
EnprostilNot Annotated
Gamolenic acidAn ingredient found in a variety of nutritional products.
Gondoic acidNot Annotated
Linoleic acidNot Annotated
cis-Vaccenic acidNot Available
Prostaglandin D2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important...
DoconexentAn omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health.
Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
DihydrocapsiateDihydrocapsiate is under investigation in clinical trial NCT00999297 (Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate).
EdasalonexentEdasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).
Drugs & Drug Targets
DrugTargetType
alpha-Linolenic acidFatty acid-binding protein, braincarrier
alpha-Linolenic acidFatty acid desaturase 1target
alpha-Linolenic acidFatty acid desaturase 2target
alpha-Linolenic acidSodium/calcium exchanger 1target
alpha-Linolenic acidTransient receptor potential cation channel subfamily V member 1target
alpha-Linolenic acidPeroxisome proliferator-activated receptor alphatarget
alpha-Linolenic acidBile acid receptortarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor deltatarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor gammatarget
alpha-Linolenic acidRetinoic acid receptor RXR-alphatarget
alpha-Linolenic acidElongation of very long chain fatty acids protein 2target
alpha-Linolenic acidElongation of very long chain fatty acids protein 5target
Dihomo-gamma-linolenic acidProstaglandin G/H synthase 2target
Dihomo-gamma-linolenic acidProstaglandin G/H synthase 1target
Dihomo-gamma-linolenic acidFatty acid-binding protein, braincarrier
IcosapentProstaglandin G/H synthase 2target
IcosapentProstaglandin G/H synthase 1target
IcosapentFree fatty acid receptor 1target
IcosapentFatty acid-binding protein, braincarrier
IcosapentFatty acid desaturase 1target
IcosapentLong-chain-fatty-acid--CoA ligase 4target
IcosapentSodium/calcium exchanger 1target
IcosapentPeroxisome proliferator-activated receptor gammatarget
IcosapentPeroxisome proliferator-activated receptor deltatarget
IcosapentTransient receptor potential cation channel subfamily V member 1target
IcosapentPeroxisome proliferator-activated receptor alphatarget
IcosapentSerum albumincarrier
TravoprostProstaglandin F2-alpha receptortarget
TreprostinilP2Y purinoceptor 12target
TreprostinilPeroxisome proliferator-activated receptor deltatarget
TreprostinilProstacyclin receptortarget
TreprostinilCytochrome P450 2C9enzyme
Carboprost tromethamineProstaglandin E2 receptor EP1 subtypetarget
LatanoprostProstaglandin F2-alpha receptortarget
LatanoprostSolute carrier organic anion transporter family member 2A1transporter
LatanoprostSolute carrier family 22 member 6transporter
LatanoprostSolute carrier family 22 member 8transporter
LatanoprostCorneal esterasesenzyme
AlprostadilProstaglandin E2 receptor EP2 subtypetarget
AlprostadilProstaglandin E2 receptor EP1 subtypetarget
AlprostadilMultidrug resistance-associated protein 5transporter
AlprostadilSolute carrier organic anion transporter family member 2B1transporter
AlprostadilSolute carrier organic anion transporter family member 3A1transporter
AlprostadilMultidrug resistance-associated protein 4transporter
AlprostadilSolute carrier organic anion transporter family member 2A1transporter
AlprostadilProstaglandin D2 receptor 2target
AlprostadilSolute carrier family 22 member 6transporter
BimatoprostProstaglandin F2-alpha receptortarget
BimatoprostProstaglandin E2 receptor EP1 subtypetarget
BimatoprostProstaglandin E2 receptor EP3 subtypetarget
BimatoprostCytochrome P450 3A4enzyme
BimatoprostCytochrome P450 3A5enzyme
DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DinoprostoneSolute carrier family 22 member 2transporter
DinoprostoneMultidrug resistance-associated protein 5transporter
DinoprostoneSolute carrier family 22 member 6transporter
DinoprostoneSolute carrier family 22 member 8transporter
DinoprostoneSolute carrier family 22 member 11transporter
DinoprostoneSolute carrier family 22 member 7transporter
DinoprostoneMultidrug resistance-associated protein 4transporter
DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DinoprostoneOrganic solute transporter subunit alphatransporter
DinoprostoneOrganic solute transporter subunit betatransporter
DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DinoprostoneProstaglandin D2 receptor 2target
MisoprostolProstaglandin E2 receptor EP2 subtypetarget
MisoprostolProstaglandin E2 receptor EP3 subtypetarget
MisoprostolProstaglandin E2 receptor EP4 subtypetarget
MisoprostolProstaglandin E2 receptor EP1 subtypetarget
LubiprostoneChloride channel protein 2target
LubiprostoneCarbonyl reductase [NADPH] 1enzyme
IloprostProstacyclin receptortarget
IloprostTissue-type plasminogen activatortarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IloprostSolute carrier organic anion transporter family member 2B1transporter
IloprostSolute carrier organic anion transporter family member 2A1transporter
IloprostSolute carrier organic anion transporter family member 3A1transporter
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
IloprostProstaglandin E2 receptor EP1 subtypetarget
IloprostProstaglandin D2 receptor 2target
Dinoprost tromethamineProstacyclin receptortarget
Dinoprost tromethamineProstaglandin F2-alpha receptortarget
Dinoprost tromethamineSolute carrier family 22 member 2transporter
Dinoprost tromethamineSolute carrier family 22 member 6transporter
Dinoprost tromethamineSolute carrier family 22 member 7transporter
Dinoprost tromethamineSolute carrier family 22 member 8transporter
Dinoprost tromethamineSolute carrier family 22 member 11transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 2A1transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 3A1transporter
EpoprostenolP2Y purinoceptor 12target
EpoprostenolProstacyclin receptortarget
EpoprostenolProstacyclin synthasetarget
Ricinoleic AcidCannabinoid receptor 1target
Ricinoleic AcidCannabinoid receptor 2target
Ricinoleic AcidTransient receptor potential cation channel subfamily V member 1target
Prostaglandin G2Prostaglandin G/H synthase 2target
Oleic AcidFatty acid-binding protein, heartcarrier
Oleic AcidFatty acid-binding protein, livercarrier
Oleic AcidSerum albumincarrier
Oleic AcidVitamin D-binding proteincarrier
Oleic Acid14 kDa fatty acid-binding proteintarget
Oleic AcidMyelin P2 proteintarget
Oleic AcidFatty acid-binding protein, braincarrier
Oleic AcidFatty acid-binding protein, adipocytecarrier
Oleic AcidPeroxisome proliferator-activated receptor alphatarget
Oleic AcidPeroxisome proliferator-activated receptor deltatarget
Oleic AcidRetinoic acid receptor RXR-alphatarget
Oleic AcidPeroxisome proliferator-activated receptor gammatarget
Palmitoleic AcidUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasetarget
Palmitoleic AcidFatty-acid peroxygenasetarget
Palmitoleic AcidBifunctional P-450/NADPH-P450 reductasetarget
Arachidonic AcidProstaglandin G/H synthase 1target
Arachidonic AcidSerum albumincarrier
Arachidonic AcidFatty acid-binding protein, adipocytecarrier
Arachidonic Acid14 kDa fatty acid-binding proteintarget
Arachidonic AcidFatty acid-binding protein, intestinalcarrier
Arachidonic AcidCytochrome P450 2C9enzyme
Arachidonic AcidSolute carrier organic anion transporter family member 2A1transporter
Arachidonic AcidPeroxisome proliferator-activated receptor alphatarget
Arachidonic AcidBile acid receptortarget
Arachidonic AcidRetinoic acid receptor RXR-alphatarget
BeraprostProstacyclin receptortarget
BeraprostCytochrome P450 2C8enzyme
CobiprostoneChloride channel protein 2target
Ethanolamine oleateCalcium ionstarget
Ethanolamine oleateCoagulation factor XIItarget
CapsaicinCytochrome P450 3A4enzyme
CapsaicinProstaglandin G/H synthase 2enzyme
CapsaicinMyeloperoxidaseenzyme
CapsaicinCytochrome P450 1A2enzyme
CapsaicinCytochrome P450 2E1enzyme
CapsaicinAmine oxidase [flavin-containing] Aenzyme
CapsaicinDopamine beta-hydroxylaseenzyme
CapsaicinGlutamine synthetaseenzyme
CapsaicinCholinesteraseenzyme
CapsaicinTransient receptor potential cation channel subfamily V member 1target
CapsaicinProhibitin-2target
TafluprostProstaglandin F2-alpha receptortarget
TafluprostProstaglandin G/H synthase 2enzyme
Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
Leukotriene C4Cysteinyl leukotriene receptor 1target
Leukotriene C4Cysteinyl leukotriene receptor 2target
Leukotriene C4Multidrug resistance-associated protein 1target
GemeprostProstaglandin E2 receptor EP2 subtypetarget
GemeprostProstaglandin E2 receptor EP3 subtypetarget
ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
ZucapsaicinCytochrome P450 1A2enzyme
ZucapsaicinCytochrome P450 2C19enzyme
ZucapsaicinCytochrome P450 2C9enzyme
ZucapsaicinCytochrome P450 2E1enzyme
LimaprostProstaglandin E2 receptor EP1 subtypetarget
LimaprostProstaglandin E2 receptor EP2 subtypetarget
LimaprostProstaglandin E2 receptor EP3 subtypetarget
LimaprostProstaglandin E2 receptor EP4 subtypetarget
Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
Omega-3 fatty acidsSterol regulatory element-binding protein 1target
NonivamideTransient receptor potential cation channel subfamily V member 1target
Evening primrose oilElongation of very long chain fatty acids protein 5enzyme
Evening primrose oilFatty acid desaturase 1enzyme
Evening primrose oilFatty acid desaturase 2enzyme
Latanoprostene bunodProstaglandin F2-alpha receptortarget
Latanoprostene bunodSolute carrier organic anion transporter family member 2B1transporter
Leukotriene D4Cysteinyl leukotriene receptor 1target
Leukotriene D4Cysteinyl leukotriene receptor 2target
DinoprostProstaglandin D2 receptor 2target
Leukotriene B4Leukotriene B4 receptor 1target
Leukotriene B4Leukotriene B4 receptor 2target
Leukotriene B4Peroxisome proliferator-activated receptor alphatarget
Omega-6 fatty acidsFatty acid desaturase 2enzyme
Omega-6 fatty acidsFatty acid desaturase 1enzyme
Omega-6 fatty acidsProstaglandin G/H synthase 2enzyme
Omega-6 fatty acidsArachidonate 5-lipoxygenaseenzyme
cis-Vaccenic acidPeroxisome proliferator-activated receptor deltatarget
Prostaglandin D2Aldo-keto reductase family 1 member C3target
Prostaglandin D2Solute carrier organic anion transporter family member 2A1transporter
Prostaglandin D2Prostaglandin D2 receptor 2target
DoconexentCytochrome P450 2C9enzyme
DoconexentPeroxisome proliferator-activated receptor alphatarget
DoconexentPeroxisome proliferator-activated receptor gammatarget
DoconexentSterol regulatory element-binding protein 1target
DoconexentRetinoic acid receptor RXR-alphatarget
DoconexentRetinoic acid receptor RXR-betatarget
DoconexentRetinoic acid receptor RXR-gammatarget
Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target