Pregnadienes

Name
Pregnadienes
Accession Number
DBCAT000747
Description

Pregnane derivatives containing two double bonds anywhere within the ring structures.

Drugs
DrugDrug Description
FlunisolideAn inhaled corticosteroid used as a prophylactic therapy in the maintenance treatment of asthma.
DiflorasoneA topical corticosteroid used to treat the symptoms of various inflammatory skin conditions that cause erythema, pruritus, and discomfort.
AlclometasoneA topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses.
AmcinonideA topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses.
FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
DydrogesteroneUsed to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history...
Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DesoximetasoneA glucocorticoid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
Fluocinolone acetonideA corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.
UlobetasolA lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
TriamcinoloneA glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
FlumethasoneA corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions.
MometasoneA corticosteroid with no indications.
ClocortoloneA corticosteroid used to treat inflammatory and pruritic dermatoses of the scalp.
PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
MethylprednisoloneA corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
Clobetasol propionateA corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.
FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
PrednicarbateA medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.
DexamethasoneA glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DesonideA topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
ParamethasoneFor the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary...
DanazolA synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.
Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
Anecortave acetateInvestigated for use/treatment in glaucoma and macular degeneration.
NCX 1015Investigated for use/treatment in arthritis and arthritic pain and inflammatory bowel disease.
DifluprednateA topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery.
FluocortoloneFluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Fluclorolone acetonideFluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
Canrenoic acidCanrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist. Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
DifluocortoloneA topical corticosteroid used for the symptomatic treatment of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis.
MedrogestoneA progestin used as an adjunct to control secondary amenorrhea and dysfunctional bleeding in adolescent and adult females, and treat endometrial shedding in menopausal women.
FluprednisoloneA synthetic glucocorticoid with anti-inflammatory properties.
MeprednisoneNot Annotated
Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
IsoflupredoneNot Annotated
MelengestrolMelengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals.
NomegestrolNomegestrol is an ingredient in the EMA-authorised product Zoely.
ClobetasolClobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
CanrenoneCanrenone has been used in trials studying the diagnostic of Heart Failure.
FluocinoloneFluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization.
PrednimustinePrednimustine has been used in trials studying the treatment of Lymphoma.
ClobetasoneA corticosteroid used to treat dry eyes, eczema, and dermatitis.
PrednylidenePrednylidene is an experimental systemic glucocorticoid.
ChlormadinoneNot Annotated
HalometasoneNot Annotated
Nomegestrol acetateNomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
Beclomethasone 17-monopropionateAn ester of beclomethasone.
Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
Prednisolone phosphateA corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions.
Prednisolone tebutateNot Annotated
Prednisolone hemisuccinateNot Annotated
Fluprednidene acetateFluprednidene acetate is a corticosteroid. It has anti-inflammatory and anti-allergic properties.
Isoflupredone acetateNot Annotated
Methylprednisolone aceponateNot Annotated
Methylprednisolone hemisuccinateA water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
Prednisone acetateNot Annotated
Dexamethasone acetateCommonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is...
Clocortolone acetateNot Annotated
Paramethasone acetateNot Annotated
Melengestrol acetateA 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus.
Betamethasone phosphateA fast acting ester prodrug of a corticosteroid used to treat inflammatory conditions.
Dexamethasone metasulfobenzoateAn ophthalmic and auricular corticosteroid used with antibiotics for the treatment of otitis externa, blepharitis, and other inflammatory eye conditions.
VamoroloneVamorolone is under investigation in clinical trial NCT03439670 (A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)).
Prednisolone acetateA glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
Drugs & Drug Targets
DrugTargetType
FlunisolideCorticosteroid-binding globulincarrier
FlunisolideGlucocorticoid receptortarget
FlunisolideCytochrome P450 3A4enzyme
DiflorasoneGlucocorticoid receptortarget
AlclometasoneCorticosteroid-binding globulincarrier
AlclometasoneGlucocorticoid receptortarget
AlclometasoneCytochrome P450 3A4enzyme
AmcinonideGlucocorticoid receptortarget
AmcinonideAnnexin A1target
AmcinonideCytochrome P450 3A4enzyme
AmcinonideCytochrome P450 3A5enzyme
FluorometholoneCorticosteroid-binding globulincarrier
FluorometholoneCytochrome P450 3A4enzyme
FluorometholoneGlucocorticoid receptortarget
FluorometholoneCytochrome P450 3A5enzyme
Megestrol acetateProgesterone receptortarget
Megestrol acetateGlucocorticoid receptortarget
Megestrol acetateP-glycoprotein 1transporter
Megestrol acetateCytochrome P450 3A4enzyme
DydrogesteroneProgesterone receptortarget
DydrogesteroneCytochrome P450 3A4enzyme
Beclomethasone dipropionateCorticosteroid-binding globulincarrier
Beclomethasone dipropionateGlucocorticoid receptortarget
Beclomethasone dipropionateCytochrome P450 3A5enzyme
Beclomethasone dipropionateCytochrome P450 3A4enzyme
Beclomethasone dipropionateP-glycoprotein 1transporter
Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
BetamethasoneGlucocorticoid receptortarget
BetamethasoneCytochrome P450 3A4enzyme
BetamethasoneP-glycoprotein 1transporter
BetamethasoneCytochrome P450 19A1enzyme
BetamethasoneCytochrome P450 3A5enzyme
BetamethasoneCytochrome P450 3A7enzyme
BetamethasoneCytochrome P450 2A6enzyme
BetamethasoneCytochrome P450 1B1enzyme
BetamethasoneCytochrome P450 2B6enzyme
BetamethasoneCytochrome P450 2C8enzyme
BetamethasoneCytochrome P450 2C9enzyme
BetamethasoneCytochrome P450 2C19enzyme
BetamethasoneSerum albumincarrier
BetamethasoneCorticosteroid-binding globulincarrier
DesoximetasoneGlucocorticoid receptortarget
Fluocinolone acetonideCorticosteroid-binding globulincarrier
Fluocinolone acetonideGlucocorticoid receptortarget
Fluocinolone acetonideCytochrome P450 3A4enzyme
Fluocinolone acetonideAnnexin A1target
Fluocinolone acetonideAnnexin A2target
Fluocinolone acetonideAnnexin A3target
Fluocinolone acetonideAnnexin A4target
Fluocinolone acetonideAnnexin A5target
UlobetasolCorticosteroid-binding globulincarrier
UlobetasolGlucocorticoid receptortarget
TriamcinoloneCorticosteroid-binding globulincarrier
TriamcinoloneGlucocorticoid receptortarget
TriamcinoloneCytochrome P450 3A4enzyme
TriamcinoloneProstaglandin G/H synthase 2enzyme
TriamcinoloneCholinesteraseenzyme
TriamcinoloneCytochrome P450 3A5enzyme
TriamcinoloneCytochrome P450 3A7enzyme
TriamcinoloneSerum albumincarrier
PrednisoneGlucocorticoid receptortarget
PrednisoneCytochrome P450 3A4enzyme
PrednisoneP-glycoprotein 1transporter
PrednisoneSolute carrier organic anion transporter family member 1A2transporter
PrednisoneCytochrome P450 2C19enzyme
PrednisoneSerum albumincarrier
PrednisoneCytochrome P450 3A5enzyme
PrednisoneCorticosteroid-binding globulincarrier
PrednisoneCytochrome P450 3A Subfamilyenzyme
PrednisoneCytochrome P450 2A6enzyme
PrednisoneCytochrome P450 1B1enzyme
PrednisoneCytochrome P450 2B6enzyme
PrednisoneCytochrome P450 2C8enzyme
PrednisoneCytochrome P450 2C9enzyme
PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
FlumethasoneCorticosteroid-binding globulincarrier
FlumethasoneGlucocorticoid receptortarget
FlumethasoneCytochrome P450 3A4enzyme
MometasoneGlucocorticoid receptortarget
MometasoneCytochrome P450 2C8enzyme
MometasoneProgesterone receptortarget
MometasoneCytochrome P450 3A4enzyme
MometasoneCytochrome P450 3A5enzyme
ClocortoloneGlucocorticoid receptortarget
PrednisoloneCorticosteroid-binding globulincarrier
PrednisoloneCytochrome P450 3A4enzyme
PrednisoloneGlucocorticoid receptortarget
PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
PrednisoloneP-glycoprotein 1transporter
PrednisoloneSerum albumincarrier
MethylprednisoloneGlucocorticoid receptortarget
MethylprednisoloneCytochrome P450 3A4enzyme
MethylprednisoloneP-glycoprotein 1transporter
MethylprednisoloneCytochrome P450 3A Subfamilyenzyme
MethylprednisoloneCytochrome P450 2A6enzyme
MethylprednisoloneCytochrome P450 1B1enzyme
MethylprednisoloneCytochrome P450 2B6enzyme
MethylprednisoloneCytochrome P450 2C8enzyme
MethylprednisoloneCytochrome P450 2C9enzyme
MethylprednisoloneCytochrome P450 2C19enzyme
MethylprednisoloneAnnexin A1target
Methylprednisolone20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme
Methylprednisolone11beta-hydroxysteroid dehydrogenaseenzyme
MethylprednisoloneSerum albumincarrier
Clobetasol propionateGlucocorticoid receptortarget
Clobetasol propionateCytochrome P450 3A4enzyme
Clobetasol propionateCytochrome P450 3A5enzyme
Clobetasol propionateAnnexin A1target
Clobetasol propionateMineralocorticoid receptortarget
Clobetasol propionateCorticosteroid-binding globulincarrier
Clobetasol propionateSerum albumincarrier
FluocinonideCorticosteroid-binding globulincarrier
FluocinonideGlucocorticoid receptortarget
FluocinonideSmoothened homologtarget
FluocinonideCytochrome P450 3A4enzyme
FluocinonideCytochrome P450 3A5enzyme
PrednicarbateGlucocorticoid receptortarget
PrednicarbateCytochrome P450 3A4enzyme
DexamethasoneGlucocorticoid receptortarget
DexamethasoneAnnexin A1target
DexamethasoneNitric oxide synthase, inducibletarget
DexamethasoneNuclear receptor subfamily 0 group B member 1target
DexamethasoneCytochrome P450 3A4enzyme
DexamethasoneCytochrome P450 3A5enzyme
DexamethasoneCytochrome P450 3A7enzyme
DexamethasoneBile salt export pumptransporter
DexamethasoneP-glycoprotein 1transporter
DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DexamethasoneATP-binding cassette sub-family G member 2transporter
DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DexamethasoneCytochrome P450 1A1enzyme
DexamethasoneCytochrome P450 2A6enzyme
DexamethasoneCytochrome P450 2B6enzyme
DexamethasoneCytochrome P450 2C19enzyme
DexamethasoneCytochrome P450 2C8enzyme
DexamethasoneCytochrome P450 2E1enzyme
DexamethasoneCytochrome P450 3A43enzyme
DexamethasoneCytochrome P450 4A11enzyme
DexamethasoneNuclear receptor subfamily 1 group I member 2target
DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DexamethasoneSerum albumincarrier
DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DexamethasoneSolute carrier family 22 member 8transporter
DesonideGlucocorticoid receptortarget
DesonideCytochrome P450 3A4enzyme
ParamethasoneCorticosteroid-binding globulincarrier
ParamethasoneGlucocorticoid receptortarget
ParamethasoneCytochrome P450 3A4enzyme
ParamethasoneCytochrome P450 3A5enzyme
DanazolEstrogen receptor alphatarget
DanazolGonadotropin-releasing hormone receptortarget
DanazolPutative gonadotropin-releasing hormone II receptortarget
DanazolSex hormone-binding globulincarrier
DanazolC-C motif chemokine 2target
DanazolCytochrome P450 19A1enzyme
DanazolAndrogen receptortarget
DanazolProgesterone receptortarget
DanazolCytochrome P450 3A4enzyme
Cyproterone acetateAndrogen receptortarget
Cyproterone acetateProstate-specific antigentarget
Cyproterone acetateCytochrome P450 3A4enzyme
Cyproterone acetateCytochrome P450 19A1enzyme
DifluprednateGlucocorticoid receptortarget
DifluprednateCytochrome P450 3A4enzyme
FluocortoloneCytochrome P450 3A4enzyme
FluocortoloneCytochrome P450 3A5enzyme
DifluocortoloneAnnexin A3target
DifluocortoloneGlucocorticoid receptortarget
DifluocortoloneCytochrome P450 3A4enzyme
DifluocortoloneCytochrome P450 3A5enzyme
MedrogestoneSerum albumincarrier
MedrogestoneProgesterone receptortarget
MedrogestoneSex hormone-binding globulincarrier
MedrogestoneCorticosteroid-binding globulincarrier
MedrogestoneCytochrome P450 3A4enzyme
FluprednisoloneCytochrome P450 3A4enzyme
MeprednisoneSerum albumincarrier
MeprednisoneCytochrome P450 3A4enzyme
MeprednisoneCytochrome P450 3A5enzyme
Dexamethasone isonicotinateCytochrome P450 3A4enzyme
Dexamethasone isonicotinateCytochrome P450 3A5enzyme
MelengestrolCytochrome P450 3A4enzyme
NomegestrolCytochrome P450 3A4enzyme
ClobetasolCytochrome P450 3A4enzyme
ClobetasolCytochrome P450 3A5enzyme
ClobetasoneGlucocorticoid receptortarget
ClobetasoneCytochrome P450 3A4enzyme
PrednylideneCytochrome P450 3A4enzyme
PrednylideneCytochrome P450 3A5enzyme
ChlormadinoneCytochrome P450 3A4enzyme
HalometasoneCytochrome P450 3A4enzyme
HalometasoneCytochrome P450 3A5enzyme
Nomegestrol acetateCytochrome P450 3A4enzyme
Mometasone furoateGlucocorticoid receptortarget
Mometasone furoateCytochrome P450 2C8enzyme
Mometasone furoateProgesterone receptortarget
Mometasone furoateCytochrome P450 3A4enzyme
Mometasone furoateCytochrome P450 3A5enzyme
Prednisolone phosphateCytochrome P450 3A4enzyme
Prednisolone phosphateCytochrome P450 3A5enzyme
Prednisolone phosphateCytochrome P450 3A Subfamilyenzyme
Prednisolone phosphateCytochrome P450 2A6enzyme
Prednisolone phosphateCytochrome P450 1B1enzyme
Prednisolone phosphateCytochrome P450 2B6enzyme
Prednisolone phosphateCytochrome P450 2C8enzyme
Prednisolone phosphateCytochrome P450 2C9enzyme
Prednisolone phosphateCytochrome P450 2C19enzyme
Prednisolone phosphateCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
Prednisolone phosphateCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
Prednisolone phosphateGlucocorticoid receptortarget
Prednisolone phosphateAnnexin A1target
Prednisolone phosphateSolute carrier organic anion transporter family member 1A2transporter
Prednisolone phosphateP-glycoprotein 1transporter
Prednisolone phosphateSolute carrier family 22 member 8transporter
Prednisolone phosphateCorticosteroid-binding globulincarrier
Prednisolone phosphateSerum albumincarrier
Prednisolone hemisuccinateCytochrome P450 3A4enzyme
Prednisolone hemisuccinateCytochrome P450 3A5enzyme
Fluprednidene acetateCytochrome P450 3A4enzyme
Fluprednidene acetateCytochrome P450 3A5enzyme
Methylprednisolone hemisuccinateCytochrome P450 3A4enzyme
Methylprednisolone hemisuccinateCytochrome P450 3A5enzyme
Prednisone acetateCytochrome P450 3A4enzyme
Prednisone acetateCytochrome P450 3A5enzyme
Dexamethasone acetateGlucocorticoid receptortarget
Dexamethasone acetateAnnexin A1target
Dexamethasone acetateNitric oxide synthase, inducibletarget
Dexamethasone acetateNuclear receptor subfamily 0 group B member 1target
Dexamethasone acetateCytochrome P450 3A4enzyme
Dexamethasone acetateCytochrome P450 3A5enzyme
Dexamethasone acetateCytochrome P450 3A7enzyme
Dexamethasone acetateBile salt export pumptransporter
Dexamethasone acetateP-glycoprotein 1transporter
Dexamethasone acetateCanalicular multispecific organic anion transporter 1transporter
Dexamethasone acetateSolute carrier organic anion transporter family member 1A2transporter
Dexamethasone acetateATP-binding cassette sub-family G member 2transporter
Dexamethasone acetateSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
Dexamethasone acetateCytochrome P450 1A1enzyme
Dexamethasone acetateCytochrome P450 2A6enzyme
Dexamethasone acetateCytochrome P450 2B6enzyme
Dexamethasone acetateCytochrome P450 2C19enzyme
Dexamethasone acetateCytochrome P450 2C8enzyme
Dexamethasone acetateCytochrome P450 2E1enzyme
Dexamethasone acetateCytochrome P450 3A43enzyme
Dexamethasone acetateCytochrome P450 4A11enzyme
Dexamethasone acetateNuclear receptor subfamily 1 group I member 2target
Dexamethasone acetateCytochrome P450 11B1, mitochondrialenzyme
Dexamethasone acetateSerum albumincarrier
Dexamethasone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
Dexamethasone acetateCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
Dexamethasone acetateSolute carrier family 22 member 8transporter
Clocortolone acetateCytochrome P450 3A4enzyme
Clocortolone acetateCytochrome P450 3A5enzyme
Melengestrol acetateCytochrome P450 3A4enzyme
Melengestrol acetateCytochrome P450 3A5enzyme
Betamethasone phosphateCytochrome P450 3A4enzyme
Betamethasone phosphateCytochrome P450 3A5enzyme
Betamethasone phosphateGlucocorticoid receptortarget
Betamethasone phosphateAnnexin A1target
Betamethasone phosphateCorticosteroid-binding globulincarrier
Betamethasone phosphateSerum albumincarrier
Betamethasone phosphateSolute carrier organic anion transporter family member 1A2transporter
Betamethasone phosphateP-glycoprotein 1transporter
Betamethasone phosphateSolute carrier family 22 member 8transporter
Prednisolone acetateCorticosteroid-binding globulincarrier
Prednisolone acetateCytochrome P450 3A4enzyme
Prednisolone acetateGlucocorticoid receptortarget
Prednisolone acetateSolute carrier organic anion transporter family member 1A2transporter
Prednisolone acetateP-glycoprotein 1transporter
Prednisolone acetateSerum albumincarrier