Pregnadienes

Pregnane derivatives containing two double bonds anywhere within the ring structures.
DrugDrug NameDrug Description
DB00180FlunisolideAn inhaled corticosteroid used as a prophylactic therapy in the maintenance treatment of asthma.
DB00223DiflorasoneA topical corticosteroid used to treat the symptoms of various inflammatory skin conditions that cause erythema, pruritus, and discomfort.
DB00240AlclometasoneA topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses.
DB00288AmcinonideA topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses.
DB00324FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
DB00351Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
DB00378DydrogesteroneUsed to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history...
DB00394Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB00547DesoximetasoneA glucocorticoid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00591Fluocinolone acetonideA corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.
DB00596UlobetasolA lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00620TriamcinoloneA glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB00663FlumethasoneA corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions.
DB00764MometasoneA corticosteroid used to treat asthma and allergic rhinitis.
DB00838ClocortoloneA corticosteroid used to treat inflammatory and pruritic dermatoses of the scalp.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00959MethylprednisoloneA corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
DB01013Clobetasol propionateA corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.
DB01047FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
DB01130PrednicarbateA medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.
DB01234DexamethasoneA glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DB01260DesonideA topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
DB01384ParamethasoneFor the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary...
DB01406DanazolA synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.
DB04839Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
DB05288Anecortave acetateInvestigated for use/treatment in glaucoma and macular degeneration.
DB05825NCX 1015Investigated for use/treatment in arthritis and arthritic pain and inflammatory bowel disease.
DB06781DifluprednateA topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery.
DB08971FluocortoloneFluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
DB08973Fluclorolone acetonideFluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
DB09015Canrenoic acidCanrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist. Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
DB09095DifluocortoloneA topical corticosteroid used for the symptomatic treatment of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis.
DB09124MedrogestoneA progestin used as an adjunct to control secondary amenorrhea and dysfunctional bleeding in adolescent and adult females, and treat endometrial shedding in menopausal women.
DB09378FluprednisoloneA synthetic glucocorticoid with anti-inflammatory properties.
DB09383MeprednisoneNot Annotated
DB11487Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
DB11522IsoflupredoneNot Annotated
DB11529MelengestrolMelengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals.
DB11636NomegestrolNomegestrol is an ingredient in the EMA-authorised product Zoely.
DB11750ClobetasolClobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
DB12221CanrenoneCanrenone has been used in trials studying the diagnostic of Heart Failure.
DB12553FluocinoloneFluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization.
DB12832PrednimustinePrednimustine has been used in trials studying the treatment of Lymphoma.
DB13158ClobetasoneA corticosteroid used to treat dry eyes, eczema, and dermatitis.
DB13208PrednylidenePrednylidene is an experimental systemic glucocorticoid.
DB13528ChlormadinoneNot Annotated
DB13728HalometasoneNot Annotated
DB13981Nomegestrol acetateNomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
DB14221Beclomethasone 17-monopropionateAn ester of beclomethasone.
DB14512Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
DB14631Prednisolone phosphateA corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions.
DB14632Prednisolone tebutateNot Annotated
DB14633Prednisolone hemisuccinateNot Annotated
DB14634Fluprednidene acetateFluprednidene acetate is a corticosteroid. It has anti-inflammatory and anti-allergic properties.
DB14640Isoflupredone acetateNot Annotated
DB14643Methylprednisolone aceponateNot Annotated
DB14644Methylprednisolone hemisuccinateA water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
DB14646Prednisone acetateNot Annotated
DB14649Dexamethasone acetateNot Annotated
DB14652Clocortolone acetateNot Annotated
DB14657Paramethasone acetateNot Annotated
DB14659Melengestrol acetateA 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus.
DB14669Betamethasone phosphateNot Annotated
DB14703Dexamethasone metasulfobenzoateAn ophthalmic and auricular corticosteroid used with antibiotics for the treatment of otitis externa, blepharitis, and other inflammatory eye conditions.
DB15114VamoroloneVamorolone is under investigation in clinical trial NCT03439670 (A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)).
DB15566Prednisolone acetateA glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
DrugDrug NameTargetType
DB00180FlunisolideCorticosteroid-binding globulincarrier
DB00180FlunisolideGlucocorticoid receptortarget
DB00180FlunisolideCytochrome P450 3A4enzyme
DB00223DiflorasoneGlucocorticoid receptortarget
DB00240AlclometasoneCorticosteroid-binding globulincarrier
DB00240AlclometasoneGlucocorticoid receptortarget
DB00240AlclometasoneCytochrome P450 3A4enzyme
DB00288AmcinonideGlucocorticoid receptortarget
DB00288AmcinonideAnnexin A1target
DB00288AmcinonideCytochrome P450 3A4enzyme
DB00288AmcinonideCytochrome P450 3A5enzyme
DB00324FluorometholoneCorticosteroid-binding globulincarrier
DB00324FluorometholoneCytochrome P450 3A4enzyme
DB00324FluorometholoneGlucocorticoid receptortarget
DB00324FluorometholoneCytochrome P450 3A5enzyme
DB00351Megestrol acetateProgesterone receptortarget
DB00351Megestrol acetateGlucocorticoid receptortarget
DB00351Megestrol acetateP-glycoprotein 1transporter
DB00351Megestrol acetateCytochrome P450 3A4enzyme
DB00378DydrogesteroneProgesterone receptortarget
DB00378DydrogesteroneCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateCorticosteroid-binding globulincarrier
DB00394Beclomethasone dipropionateGlucocorticoid receptortarget
DB00394Beclomethasone dipropionateCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateP-glycoprotein 1transporter
DB00394Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00547DesoximetasoneGlucocorticoid receptortarget
DB00591Fluocinolone acetonideCorticosteroid-binding globulincarrier
DB00591Fluocinolone acetonideGlucocorticoid receptortarget
DB00591Fluocinolone acetonideCytochrome P450 3A4enzyme
DB00591Fluocinolone acetonideAnnexin A1target
DB00591Fluocinolone acetonideAnnexin A2target
DB00591Fluocinolone acetonideAnnexin A3target
DB00591Fluocinolone acetonideAnnexin A4target
DB00591Fluocinolone acetonideAnnexin A5target
DB00596UlobetasolCorticosteroid-binding globulincarrier
DB00596UlobetasolGlucocorticoid receptortarget
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB00620TriamcinoloneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCytochrome P450 3A7enzyme
DB00620TriamcinoloneSerum albumincarrier
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00635PrednisoneCorticosteroid-binding globulincarrier
DB00635PrednisoneCytochrome P450 3A Subfamilyenzyme
DB00635PrednisoneCytochrome P450 2A6enzyme
DB00635PrednisoneCytochrome P450 1B1enzyme
DB00635PrednisoneCytochrome P450 2B6enzyme
DB00635PrednisoneCytochrome P450 2C8enzyme
DB00635PrednisoneCytochrome P450 2C9enzyme
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB00663FlumethasoneCorticosteroid-binding globulincarrier
DB00663FlumethasoneGlucocorticoid receptortarget
DB00663FlumethasoneCytochrome P450 3A4enzyme
DB00764MometasoneGlucocorticoid receptortarget
DB00764MometasoneCytochrome P450 2C8enzyme
DB00764MometasoneProgesterone receptortarget
DB00764MometasoneCytochrome P450 3A4enzyme
DB00764MometasoneCytochrome P450 3A5enzyme
DB00838ClocortoloneGlucocorticoid receptortarget
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneP-glycoprotein 1transporter
DB00959MethylprednisoloneCytochrome P450 3A Subfamilyenzyme
DB00959MethylprednisoloneCytochrome P450 2A6enzyme
DB00959MethylprednisoloneCytochrome P450 1B1enzyme
DB00959MethylprednisoloneCytochrome P450 2B6enzyme
DB00959MethylprednisoloneCytochrome P450 2C8enzyme
DB00959MethylprednisoloneCytochrome P450 2C9enzyme
DB00959MethylprednisoloneCytochrome P450 2C19enzyme
DB00959MethylprednisoloneAnnexin A1target
DB00959Methylprednisolone20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme
DB00959Methylprednisolone11beta-hydroxysteroid dehydrogenaseenzyme
DB00959MethylprednisoloneSerum albumincarrier
DB01013Clobetasol propionateGlucocorticoid receptortarget
DB01013Clobetasol propionateCytochrome P450 3A4enzyme
DB01013Clobetasol propionateCytochrome P450 3A5enzyme
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB01047FluocinonideCytochrome P450 3A5enzyme
DB01130PrednicarbateGlucocorticoid receptortarget
DB01130PrednicarbateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneP-glycoprotein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DB01234DexamethasoneSerum albumincarrier
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB01234DexamethasoneSolute carrier family 22 member 8transporter
DB01260DesonideGlucocorticoid receptortarget
DB01260DesonideCytochrome P450 3A4enzyme
DB01384ParamethasoneCorticosteroid-binding globulincarrier
DB01384ParamethasoneGlucocorticoid receptortarget
DB01384ParamethasoneCytochrome P450 3A4enzyme
DB01384ParamethasoneCytochrome P450 3A5enzyme
DB01406DanazolEstrogen receptor alphatarget
DB01406DanazolGonadotropin-releasing hormone receptortarget
DB01406DanazolPutative gonadotropin-releasing hormone II receptortarget
DB01406DanazolSex hormone-binding globulincarrier
DB01406DanazolC-C motif chemokine 2target
DB01406DanazolCytochrome P450 19A1enzyme
DB01406DanazolAndrogen receptortarget
DB01406DanazolProgesterone receptortarget
DB01406DanazolCytochrome P450 3A4enzyme
DB04839Cyproterone acetateAndrogen receptortarget
DB04839Cyproterone acetateProstate-specific antigentarget
DB04839Cyproterone acetateCytochrome P450 3A4enzyme
DB04839Cyproterone acetateCytochrome P450 19A1enzyme
DB06781DifluprednateGlucocorticoid receptortarget
DB06781DifluprednateCytochrome P450 3A4enzyme
DB08971FluocortoloneCytochrome P450 3A4enzyme
DB08971FluocortoloneCytochrome P450 3A5enzyme
DB09095DifluocortoloneAnnexin A3target
DB09095DifluocortoloneGlucocorticoid receptortarget
DB09095DifluocortoloneCytochrome P450 3A4enzyme
DB09095DifluocortoloneCytochrome P450 3A5enzyme
DB09124MedrogestoneSerum albumincarrier
DB09124MedrogestoneProgesterone receptortarget
DB09124MedrogestoneSex hormone-binding globulincarrier
DB09124MedrogestoneCorticosteroid-binding globulincarrier
DB09124MedrogestoneCytochrome P450 3A4enzyme
DB09378FluprednisoloneCytochrome P450 3A4enzyme
DB09383MeprednisoneSerum albumincarrier
DB09383MeprednisoneCytochrome P450 3A4enzyme
DB09383MeprednisoneCytochrome P450 3A5enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A4enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A5enzyme
DB11529MelengestrolCytochrome P450 3A4enzyme
DB11636NomegestrolCytochrome P450 3A4enzyme
DB11750ClobetasolCytochrome P450 3A4enzyme
DB11750ClobetasolCytochrome P450 3A5enzyme
DB13158ClobetasoneGlucocorticoid receptortarget
DB13158ClobetasoneCytochrome P450 3A4enzyme
DB13208PrednylideneCytochrome P450 3A4enzyme
DB13208PrednylideneCytochrome P450 3A5enzyme
DB13528ChlormadinoneCytochrome P450 3A4enzyme
DB13728HalometasoneCytochrome P450 3A4enzyme
DB13728HalometasoneCytochrome P450 3A5enzyme
DB13981Nomegestrol acetateCytochrome P450 3A4enzyme
DB14512Mometasone furoateGlucocorticoid receptortarget
DB14512Mometasone furoateCytochrome P450 2C8enzyme
DB14512Mometasone furoateProgesterone receptortarget
DB14512Mometasone furoateCytochrome P450 3A4enzyme
DB14512Mometasone furoateCytochrome P450 3A5enzyme
DB14631Prednisolone phosphateCytochrome P450 3A4enzyme
DB14631Prednisolone phosphateCytochrome P450 3A5enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14634Fluprednidene acetateCytochrome P450 3A4enzyme
DB14634Fluprednidene acetateCytochrome P450 3A5enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14646Prednisone acetateCytochrome P450 3A4enzyme
DB14646Prednisone acetateCytochrome P450 3A5enzyme
DB14652Clocortolone acetateCytochrome P450 3A4enzyme
DB14652Clocortolone acetateCytochrome P450 3A5enzyme
DB14659Melengestrol acetateCytochrome P450 3A4enzyme
DB14659Melengestrol acetateCytochrome P450 3A5enzyme
DB14669Betamethasone phosphateCytochrome P450 3A4enzyme
DB14669Betamethasone phosphateCytochrome P450 3A5enzyme
DB15566Prednisolone acetateCorticosteroid-binding globulincarrier
DB15566Prednisolone acetateCytochrome P450 3A4enzyme
DB15566Prednisolone acetateGlucocorticoid receptortarget
DB15566Prednisolone acetateSolute carrier organic anion transporter family member 1A2transporter
DB15566Prednisolone acetateP-glycoprotein 1transporter
DB15566Prednisolone acetateSerum albumincarrier