Identification

Name
Triamcinolone
Accession Number
DB00620  (APRD00422)
Type
Small Molecule
Groups
Approved, Vet approved
Description

Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.13 Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,16 or first line as a topical treatment of corticosteroid responsive dermatoses.11 Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.10,11,12,13,14,15,16

Triamcinolone was granted FDA approval on 3 December 1957.9

Structure
Thumb
Synonyms
  • 11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
  • 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-16α-hydroxyprednisolone
  • Fluoxyprednisolone
  • Tiamcinolonum
  • Triamcinolona
  • Triamcinolone
  • Triamcinolonum
Product Ingredients
IngredientUNIICASInChI Key
Triamcinolone acetonideF446C597KA76-25-5YNDXUCZADRHECN-JNQJZLCISA-N
Triamcinolone diacetateA73MM2Q32P67-78-7XGMPVBXKDAHORN-RBWIMXSLSA-N
Triamcinolone hexacetonideI7GT1U99Y95611-51-8TZIZWYVVGLXXFV-FLRHRWPCSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AllerNazeSpray, metered0.5 mg/1mLNasalLupin Pharmaceuticals2011-02-01Not applicableUs
AristocortInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Intrasynovial; ParenteralSandoz1961-09-051961-09-05Us
AristocortInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Intrasynovial; ParenteralPhysicians Total Care, Inc.1961-09-052005-07-28Us
Aristocort - Syr Orl 0.4mg/mlSyrupOralGlades, Division Of Stiefel Canada Inc.1996-10-101997-08-05Canada
Aristocort - Tab 4mgTabletOralGlades, Division Of Stiefel Canada Inc.1998-05-112004-01-27Canada
Aristocort CCreamTopicalValeant Canada Lp Valeant Canada S.E.C.1997-10-21Not applicableCanada
Aristocort C Crm 0.5%CreamTopicalLederle Cyanamid Canada Inc.1965-12-311997-08-14Canada
Aristocort D - Crm Top 0.025%CreamTopicalGlades, Division Of Stiefel Canada Inc.1996-10-101998-07-09Canada
Aristocort D Crm 0.025%CreamTopicalLederle Cyanamid Canada Inc.1974-12-311997-01-29Canada
Aristocort Forte - Liq Ia Im Isy 40mg/mlLiquidIntra-articular; Intramuscular; IntrasynovialGlades, Division Of Stiefel Canada Inc.1996-12-062000-12-04Canada
Additional Data Available
  • Application Number
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  • Product Code
    Product Code

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-triamcinolone AQSpray, meteredNasalApotex Corporation2016-06-15Not applicableCanada
DermacinRx Silazone PakKit1 mg/1gPureTek Corporation2015-12-10Not applicableUs
DermacinRx TrizapakKit1 mg/1gTopicalPure Tek Corporation2016-08-022017-08-17Us
Dermasorb TA Complete Kit1 mg/1gTopicalCrown Laboratories2013-11-142019-08-30Us
DermazoneKit1 mg/1gShoreline Pharmaceuticals, Inc.2016-04-20Not applicableUs
Juulissa PharmapakKit1 mg/1gTopicalPureTek Corporation2016-12-28Not applicableUs
KenalogOintment5 mg/1gTopicalE.R. Squibb & Sons, L.L.C.2007-01-012007-08-31Us
KenalogLotion1 mg/1mLTopicalE.R. Squibb & Sons, L.L.C.2007-01-012007-12-31Us
KenalogLotion0.25 mg/1mLTopicalE.R. Squibb & Sons, L.L.C.2005-01-012005-03-31Us
OralonePaste1 mg/1gDentalTaro Pharmaceuticals U.S.A., Inc.1986-10-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Nasal AllergySpray, metered55 ug/1NasalMeijer Distribution Inc2017-01-18Not applicableUs
24 Hour Nasal AllergySpray, metered55 ug/1NasalKroger Company2016-04-10Not applicableUs
Allergy NasalSpray, metered55 ug/1NasalWalgreen Company2016-04-10Not applicableUs
Basic Care Nasal AllergySpray, metered55 ug/1NasalL. Perrigo Company2018-04-25Not applicableUs
CareOne Allergy ReliefSpray, metered55 ug/1NasalAmerican Sales Company2017-06-12Not applicableUs
Childrens Nasacort Allergy 24HRSpray, metered55 ug/1NasalChattem, Inc.2015-07-01Not applicableUs
Childrens Nasal AllergySpray, metered55 ug/1NasalCVS PHARMACY2018-06-28Not applicableUs
Equaline nasal allergySpray, metered55 ug/1NasalSUPERVALU INC2016-12-29Not applicableUs
Equate Nasal AllergySpray, metered55 ug/1NasalWAL-MART STORES INC2016-04-17Not applicableUs
Good Neighbor Pharmacy 24 Hour Nasal AllergySpray, metered55 ug/1NasalAmerisource Bergen2016-10-24Not applicableUs
Additional Data Available
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Aristoform R Crm 0.1%Triamcinolone acetonide (1 mg) + Clioquinol (30 mg)CreamTopicalLederle Cyanamid Canada Inc.1966-12-311997-01-29Canada
BtTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Isopropyl alcohol (0.7 mL/1) + Povidone-iodine (0.10 g/1)KitTopicalSa3, Llc2015-07-01Not applicableUs
Cortaren Corticosteroid/Anti-Inflammatory SystemTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Dexamethasone sodium phosphate (4 mg/1mL) + Isopropyl alcohol (0.7 mL/1mL)TopicalIt3 Medical Llc2017-03-01Not applicableUs
DermacinRx Cinlone-I CPITriamcinolone acetonide (40 mg/1mL) + Lidocaine (25 mg/1g) + Prilocaine (25 mg/1g)KitIntra-articular; IntramuscularPure Tek Corporation2016-05-17Not applicableUs
DermacinRx Cinlone-II CPITriamcinolone acetonide (40 mg/1mL) + Lidocaine (25 mg/1g) + Prilocaine (25 mg/1g)KitIntra-articular; IntramuscularPure Tek Corporation2016-06-24Not applicableUs
DermacinRx SilaPakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitTopicalNucare Pharmaceuticals,inc.2015-08-182018-10-15Us
DermacinRx SilaPakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitPureTek Corporation2015-06-23Not applicableUs
DermacinRx SilaPakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitTopicalPure Tek Corporation2015-08-182018-08-16Us
Dermasilkrx SDSpakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitTopicalPatchwerx Labs2015-07-20Not applicableUs
Dermawerx SDS PakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitTopicalPatchwerx Labs2015-07-20Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bupivilog KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
Calcipotriene 0.005% / Triamcinolone Acetonide 0.1%Triamcinolone acetonide (0.1 g/100g) + Calcipotriol (0.005 g/100g)OintmentTopicalSincerus Florida, LLC2019-05-11Not applicableUs
Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%Triamcinolone acetonide (0.025 g/100g) + Hydroquinone (4 g/100g) + Tretinoin (0.025 g/100g)EmulsionTopicalSincerus Florida, LLC2019-05-20Not applicableUs
Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025%Triamcinolone acetonide (0.025 g/100g) + Hydroquinone (5 g/100g) + Tretinoin (0.025 g/100g)EmulsionTopicalSincerus Florida, LLC2019-05-20Not applicableUs
Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025%Triamcinolone acetonide (0.025 g/100g) + Hydroquinone (6 g/100g) + Tretinoin (0.05 g/100g)EmulsionTopicalSincerus Florida, LLC2019-05-20Not applicableUs
Interarticular Joint KitTriamcinolone acetonide (40 mg/1mL) + Ammonia (0.045 g/0.3mL) + Lidocaine hydrochloride anhydrous (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-02-052015-06-19Us
Levocetirizine Dihydrochloride 2% / Mupirocin 2% / Triamcinolone Acetonide 0.025%Triamcinolone acetonide (0.025 g/100g) + Levocetirizine dihydrochloride (2 g/100g) + Mupirocin (2 g/100g)CreamTopicalSincerus Florida, LLC2019-05-15Not applicableUs
Lidolog KitTriamcinolone acetonide (40 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2018-05-10Not applicableUs
MLK F1 KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-01-16Not applicableUs
MLK F3 KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Lidocaine hydrochloride anhydrous (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
International/Other Brands
Delphicort / Flutex / Kenacort / Omcilon-A / Oracort / Tri-Nasal / Triacet / Triacort / Triaderm / Tricortone / Trilone / Tristoject
Categories
UNII
1ZK20VI6TY
CAS number
124-94-7
Weight
Average: 394.4339
Monoisotopic: 394.179166801
Chemical Formula
C21H27FO6
InChI Key
GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
IUPAC Name
(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
SMILES
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Pharmacology

Indication

Triamcinolone hexacetonide injections are indicated for intralesional administration in alopecia areata, discoid lupus erythematosus, keloids, and necrobiosis lipoidica diabeticorum.10 This formulation can also be used for localized hypertrophic infiltrated inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus, and psoriatic plaques.10

Triamcinolone acetonide spray and cream are indicated for the treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.11,14 A triamcinolone acetonide 10mg/mL or 40mg/mL injection is indicated intra-articularly for acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, and synovitis of osteoarthritis.12,13 The same 10mg/mL injection is indicated by the intralesional route for the treatment of alopecia areata, discoid lupus erythematosus, keloids, necrobiosis lipoidica diabeticorum, and tumors of an aponeurosis or tendon.12 This formulation can also be used for localized hypertrophic infiltrated inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus, and psoriatic plaques.12 The 40mg/mL injection is indicated intramuscularly for controlling severe allergic conditions such as asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity, perennial or seasonal allergic rhinitis, serum sickness, and transfusion reactions; treatment of bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, Stevens-Johnson syndrome, congenital adrenal hyperplasia, hypercalcemia in cancer, nonsuppurative thyroiditis, autoimmune hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, secondary thrombocytopenia, trichinosis, tuberculous meningitis, acute exacerbations of multiple sclerosis or cerebral edema, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, berylliosis, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis, dermatomyositis, polymyositis, and systemic lupus erythematosus; adjunct treatment of adrenocortical insufficiency, regional enteritis, ulcerative colitis, fulminating or disseminated pulmonary tuberculosis, acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis; palliative management of leukemia and lymphoma; induction of diuresis or remission of proteinuria in idiopathic nephrotic syndrome or lupus erythematosus.13 A triamcinolone intravitreal injection is indicated for the treatment of sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammatory conditions.15 The intravitreal injection is also used for visualization during vitrectomy.15 An extended release suspension is indicated intra-articularly for management of pain in osteoarthritis of the knee.16

Associated Conditions
Pharmacodynamics

Triamcinolone is a corticosteroid with anti-inflammatory properties.8 These properties are used to treat inflammation in conditions that affect various organs and tissues.15 Triamcinolone should not be administered as an epidural injection.10,12,13,15,16

Mechanism of action

Corticosteroids like triamcinolone inhibit phospholipase A2 on cell membranes, preventing the breakdown of lysosomal membranes of leukocytes, which in turn prevent the formation of arachidonic acid, which decrease expression of cyclooxygenase and lipoxygenase, inhibiting synthesis of prostaglandins and leukotrienes.8 Anti-inflammatory activity occurs via reversal of vascular dilation and reducing permeability, which prevents macrophage and leukocyte migration.8 Triamcinolone also inhibits nuclear factor kappa-B, which decreases the production of pro-inflammatory signals such as interleukin-6, interleukin-8, and monocyte chemoattractant protein-1.8

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Humans
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Absorption

A 16mg oral dose of triamcinolone reaches a Cmax of 5.23±0.84ng/mL with a Tmax of 2.24±0.78h and an AUC of 36.0±6.2ng*h/mL.4

A 2mg intravenous dose of triamcinolone acetonide has an AUC of 57.7ng*h/mL.3 The bioavailability of 800µg of inhaled triamcinolone acetonide is 25%, with 10.4% coming from pulmonary absorption and the rest being accounted for by deposition on the oral mucosa and other underlying factors.2 An inhaled dose of triamcinolone acetonide reaches a Cmax of 0.92ng/mL with a Tmax of 1.74h and an AUC of 5.12ng*h/mL.2 The fraction of an inhaled dose that is actually absorbed via the pulmonary route reaches a Cmax of 0.55ng/mL with a Tmax of 0.66h and an AUC of 2.15ng*h/mL.2

A 16mg oral dose of triamcinolone diacetate reaches a Cmax of 5.33±1.55ng/mL with a Tmax of 1.86±0.47h and an AUC of 32.7±9.9ng*h/mL.4

Volume of distribution

The apparent volume of distribution of triamcinolone is 115.2±10L.4 The mean apparent volume of distribution of triamcinolone acetonide is 1.96L/kg.2 The apparent volume of distribution of triamcinolone diacetate is 119.7±33.14L.4

Protein binding

Triamcinolone is mostly bound to corticosteroid-binding globulin or serum albumin.5 Triamcinolone acetonide is approximately 68% protein bound in plasma.7

Metabolism

The major metabolite of triamcinolone is 6-beta-hydroxy-triamcinolone.1 Data regarding the metabolism of triamcinolone is not readily available.10,11,12,13,14,15,16,17

Route of elimination

Approximately 20% of a dose of triamcinolone is recovered in the urine as the unchanged drug, 25% is recovered as 6-beta-hydroxy-triamcinolone, and 5% is recovered as unidentified metabolites.1

Half life

The half life of triamcinolone is 2.7h.4 The mean terminal elimination half life following an inhaled dose of triamcinolone acetonide is 2.4h.2 The half life of triamcinolone diacetate is 2.8h.4

Clearance

The clearance of triamcinolone is 28.6±5.6L/h.4 The mean total body clearance of triamcinolone acetonide is 0.57L/h.2 The clearance of triamcinolone diacetate is 34.4±10.6L/h.4

Toxicity

The subcutaneous LD50 of triamcinolone acetonide in rats is 13,100µg/kg and in mice is 132mg/kg.17 The oral LD50 in rats is 1451mg/kg and in mice is 2168mg/kg.[LD50] The intraperitoneal LD50 in mice is 105mg/kg.[LD50]

Patients experiencing an overdose may develop Cushing's syndrome.6 This overdose may be treated with supportive therapy and mifepristone for its antiglucocorticoid activity.6

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Triamcinolone.
(S)-WarfarinThe therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Triamcinolone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Triamcinolone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Triamcinolone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Triamcinolone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Triamcinolone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Triamcinolone.
1alpha,24S-Dihydroxyvitamin D2The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Triamcinolone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe risk or severity of hyperglycemia can be increased when Triamcinolone is combined with 2,4-thiazolidinedione.
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Food Interactions
No interactions found.

References

Synthesis Reference

Abu Alam, "Triamcinolone formulations and methods for their preparation and use." U.S. Patent US20040186084, issued September 23, 2004.

US20040186084
General References
  1. FLORINI JR, SMITH LL, BUYSKE DA: Metabolic fate of a synthetic corticosteroid (triamcinolone) in the dog. J Biol Chem. 1961 Apr;236:1038-42. [PubMed:13700367]
  2. Argenti D, Shah B, Heald D: A pharmacokinetic study to evaluate the absolute bioavailability of triamcinolone acetonide following inhalation administration. J Clin Pharmacol. 1999 Jul;39(7):695-702. doi: 10.1177/00912709922008335. [PubMed:10392324]
  3. Derendorf H, Hochhaus G, Rohatagi S, Mollmann H, Barth J, Sourgens H, Erdmann M: Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration. J Clin Pharmacol. 1995 Mar;35(3):302-5. doi: 10.1002/j.1552-4604.1995.tb04064.x. [PubMed:7608322]
  4. Hochhaus G, Portner M, Barth J, Mollmann H, Rohdewald P: Oral bioavailability of triamcinolone tablets and a triamcinolone diacetate suspension. Pharm Res. 1990 May;7(5):558-60. doi: 10.1023/a:1015889305157. [PubMed:1973290]
  5. FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. [PubMed:13700365]
  6. Schweitzer DH, Le-Brun PP, Krishnaswami S, Derendorf H: Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study. Neth J Med. 2000 Jan;56(1):12-6. [PubMed:10667036]
  7. Argenti D, Jensen BK, Hensel R, Bordeaux K, Schleimer R, Bickel C, Heald D: A mass balance study to evaluate the biotransformation and excretion of [14C]-triamcinolone acetonide following oral administration. J Clin Pharmacol. 2000 Jul;40(7):770-80. doi: 10.1177/00912700022009413. [PubMed:10883419]
  8. Sidhu G, Preuss CV: Triamcinolone . [PubMed:31335029]
  9. FDA Approved Drug Products: Aristocort Triamcinolone Oral Tablets (Discontinued) [Link]
  10. FDA Approved Drug Products: Triamcinolone Hexacetonide Injection [Link]
  11. FDA Approved Drug Products: Triamcinolone Acetonide Topical Spray [Link]
  12. FDA Approved Drug Products: Triamcinolone Acetonide 10mg/mL Injection [Link]
  13. FDA Approved Drug Products: Triamcinolone Acetonide 40mg/mL Injection [Link]
  14. FDA Approved Drug Products: Triamcinolone Acetonide Topical Cream [Link]
  15. FDA Approved Drug Products: Triamcinolone Acetonide Intravitreal Injection [Link]
  16. FDA Approved Drug Products: Triamcinolone Acetonide Intraarticular Extended Release Suspension [Link]
  17. Cayman Chemicals: Triamcinolone Acetonide MSDS [Link]
External Links
Human Metabolome Database
HMDB0014758
KEGG Drug
D00385
PubChem Compound
31307
PubChem Substance
46507950
ChemSpider
29046
BindingDB
41132
RxNav
10759
ChEBI
9667
ChEMBL
CHEMBL1451
ZINC
ZINC000003882036
Therapeutic Targets Database
DAP000417
PharmGKB
PA451749
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Triamcinolone
ATC Codes
D07AB09 — TriamcinoloneR01AD11 — TriamcinoloneR03BA06 — TriamcinoloneD07BB03 — Triamcinolone and antisepticsA01AC01 — TriamcinoloneH02AB08 — TriamcinoloneD07CB01 — Triamcinolone and antibioticsS01BA05 — TriamcinoloneD07XB02 — TriamcinoloneS02CA04 — Triamcinolone and antiinfectivesC05AA12 — Triamcinolone
AHFS Codes
  • 68:04.00 — Adrenals
  • 84:06.00 — Anti-inflammatory Agents
  • 52:08.08 — Corticosteroids
FDA label
Download (150 KB)
MSDS
Download (72.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticDiabetic Retinopathy (DR)1
0Not Yet RecruitingTreatmentHumeral Fractures1
0Not Yet RecruitingTreatmentOral Lichen Planus1
0RecruitingTreatmentBacterial Sinusitis / Chronic Rhinosinusitis1
0RecruitingTreatmentEndometriosis of Uterus / Uterine Leiomyomas1
0RecruitingTreatmentOral Lichen Planus1
0RecruitingTreatmentPsoriasis Vulgaris (Plaque Psoriasis) / Vitamin D31
0Unknown StatusTreatmentGreater Trochanteric Pain Syndrome1
1CompletedTreatmentCystoid Macular Edema1
1CompletedTreatmentDiabetic Macular Edema (DME)2
1CompletedTreatmentDiabetic Retinopathy (DR) / Macular Degeneration / Retinal Vein Occlusion1
1CompletedTreatmentMacular Degeneration / Retinal Vein Occlusion1
1CompletedTreatmentMaculopathies, Age-Related1
1CompletedTreatmentVasoconstriction1
1Enrolling by InvitationBasic ScienceCochlear Hearing Loss1
1Not Yet RecruitingBasic ScienceKnee Osteoarthritis (Knee OA)1
1Not Yet RecruitingTreatmentOral Lichen Planus1
1RecruitingTreatmentFibromatosis1
1TerminatedDiagnosticFibrosis1
1TerminatedTreatmentRotator Cuff Syndrome1
1Unknown StatusTreatmentCystoid Macular Edema / Uveitis1
1Unknown StatusTreatmentDiabetic Macular Edema (DME) / Diabetic Retinopathy (DR)1
1Unknown StatusTreatmentResistant Cystoid Macular Edema1
1, 2CompletedSupportive CareMucositis1
1, 2CompletedTreatmentAge-Related Macular Degeneration (ARMD) / Subfoveal Choroidal Neovascularization1
1, 2CompletedTreatmentChorioretinitis / Noninfectious Uveitis / Panuveitis / Uveitis / Uveitis, Intermediate1
1, 2CompletedTreatmentDiabetic Macular Edema (DME)1
1, 2TerminatedTreatmentPolyps, Nasal1
1, 2Unknown StatusTreatmentAcute Nonarteritic Anterior Ischemic Optic Neuropathy1
1, 2Unknown StatusTreatmentDiabetic Macular Edema (DME)1
1, 2Unknown StatusTreatmentDiabetic Retinopathy (DR)2
2CompletedBasic ScienceDiabetic Macular Edema (DME)1
2CompletedScreeningAlopecia Areata (AA)1
2CompletedTreatmentAbdominal Pain1
2CompletedTreatmentAcute Gouty Arthritis2
2CompletedTreatmentAge-Related Macular Degeneration (ARMD)1
2CompletedTreatmentAnterior Cruciate Ligament (ACL) Tears1
2CompletedTreatmentAtopic Dermatitis (AD)3
2CompletedTreatmentBilateral Knee Osteoarthritis1
2CompletedTreatmentBranch Retinal Vein Occlusion1
2CompletedTreatmentCataracts / Vitrectomy therapy1
2CompletedTreatmentDiabetic Macular Edema (DME)5
2CompletedTreatmentDiabetic Retinopathy (DR)1
2CompletedTreatmentHand Dermatosis1
2CompletedTreatmentKnee Osteoarthritis (Knee OA)5
2CompletedTreatmentKnee Osteoarthritis (Knee OA) / Type 2 Diabetes Mellitus1
2CompletedTreatmentMelanoma1
2CompletedTreatmentNon-Melanomatous Skin Cancer / Precancerous/Nonmalignant Condition1
2CompletedTreatmentOral Lichen Planus1
2CompletedTreatmentOsteoarthritis of the Hip / Osteoarthritis of the Shoulder1
2CompletedTreatmentShoulder Pain1
2Not Yet RecruitingTreatmentErosive Oral Lichen Planus1
2Not Yet RecruitingTreatmentJoint Diseases / Knee / Magnetic Resonance Imaging (MRI) / Therapeutics1
2Not Yet RecruitingTreatmentTrochanteric Bursitis1
2RecruitingPreventionAcneiform Rash / Papulopustular Eruption1
2RecruitingSupportive CareCutaneous T-Cell Lymphoma (CTCL) / Cutaneous T-cell Lymphoma Stage I / Folliculotropic Mycosis Fungoides / Granulomatous Slack Skin / Mycosis Fungoides (MF) / Mycosis Fungoides Variant / Syringotropic Mycosis Fungoides / Transformed Mycosis Fungoides1
2RecruitingTreatmentAdhesive Capsulitis / Osteoarthritis of the Shoulder1
2RecruitingTreatmentAsthma in Children1
2RecruitingTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
2RecruitingTreatmentPsoriasis1
2RecruitingTreatmentVitiligo1
2TerminatedTreatmentAge-Related Macular Degeneration (ARMD)1
2TerminatedTreatmentMacular Edema1
2TerminatedTreatmentPost-traumatic Osteoarthritis of the Knee1
2Unknown StatusTreatmentBranch Retinal Vein Occlusion1
2Unknown StatusTreatmentCentral Retinal Vein Occlusion (CRVO)1
2Unknown StatusTreatmentDiabetic Retinopathy (DR)1
2Unknown StatusTreatmentHemiparesis / Shoulder Pain / Stroke1
2Unknown StatusTreatmentRetinovascular Disease1
2Unknown StatusTreatmentShoulder Pain1
2Unknown StatusTreatmentWet Macular Degeneration1
2WithdrawnTreatmentMacular Edema / Uveitis1
2, 3CompletedTreatmentAge-Related Macular Degeneration (ARMD) / Subfoveal Choroidal Neovascularization1
2, 3CompletedTreatmentCentral Retinal Vein Occlusion (CRVO)1
2, 3CompletedTreatmentDiabetic Macular Edema (DME)3
2, 3CompletedTreatmentDiabetic Macular Edema (DME) / Macular Edema1
2, 3CompletedTreatmentDiabetic Retinopathy (DR)1
2, 3CompletedTreatmentGlaucoma1
2, 3Not Yet RecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
2, 3Not Yet RecruitingTreatmentFlail Chest1
2, 3RecruitingTreatmentChronic Rhinosinusitis / Polyps, Nasal1
2, 3RecruitingTreatmentKnee Arthritis1
2, 3RecruitingTreatmentProliferative Diabetic Retinopathy (PDR)1
2, 3RecruitingTreatmentTrigger Digit1
2, 3RecruitingTreatmentVitiligo1
2, 3SuspendedTreatmentMelasma1
2, 3Unknown StatusTreatmentAge-Related Macular Degeneration (ARMD)1
2, 3Unknown StatusTreatmentMelanoma, Uveal1
2, 3Unknown StatusTreatmentSubfoveal Choroidal Neovascularization1
3Active Not RecruitingTreatmentAdhesive Capsulitis of Shoulder / Shoulder Adhesive Capsulitis / Shoulder Capsulitis1
3Active Not RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
3CompletedPreventionCataracts / Cystoid Macular Edema / Diabetes Mellitus1
3CompletedTreatmentAcute Gouty Arthritis3
3CompletedTreatmentAllergic Rhinitis (AR)1
3CompletedTreatmentAnterior Uveitis (AU) / Chorioretinitis / Panuveitis / Uveitis / Uveitis, Intermediate2
3CompletedTreatmentChronic Lung Diseases / Chronic Obstructive Pulmonary Disease (COPD) / Lung Diseases, Obstructive1
3CompletedTreatmentDiabetic Macular Edema (DME) / Diabetic Retinopathy (DR) / DME1
3CompletedTreatmentDiabetes / Diabetic Macular Edema (DME)1
3CompletedTreatmentDiabetic Macular Edema (DME)3
3CompletedTreatmentDiabetic Macular Edema (DME) / Diabetic Retinopathy (DR)1
3CompletedTreatmentDiabetic Macular Edema (DME) / Proliferative Diabetic Retinopathy (PDR)1
3CompletedTreatmentDiabetic Retinopathy (DR) / Macular Edema1
3CompletedTreatmentDupuytren's Contracture of the Hand (Viking's Disease)1
3CompletedTreatmentKnee Osteoarthritis (Knee OA)4
3CompletedTreatmentMacular Degeneration1
3CompletedTreatmentMacular Degeneration / Subfoveal Choroidal Neovascularization1
3CompletedTreatmentMacular Edema, Cystoid / Retinal Vein Occlusion1
3CompletedTreatmentMacular Edema / Macular Edema, Cystoid / Retinal Vein Occlusion1
3CompletedTreatmentMacular Edema / Uveitis1
3CompletedTreatmentNegative Middle Ear Pressure / Otitis Media, Serous / Rhinitis1
3CompletedTreatmentOral Lichen Planus1
3CompletedTreatmentOral Pemphigus Vulgaris1
3CompletedTreatmentOsteoarthritis (OA)1
3CompletedTreatmentPancreatitis, Chronic1
3CompletedTreatmentRadicular syndrome1
3CompletedTreatmentRetinal Vein Occlusion1
3CompletedTreatmentRhinitis, Allergic, Perennial1
3CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
3CompletedTreatmentVitrectomy therapy1
3CompletedTreatmentVitreoretinopathy, Proliferative1
3Not Yet RecruitingOtherCarpal Tunnel Syndrome (CTS) / De Quervains Tenosynovitis / Trigger Finger1
3Not Yet RecruitingTreatmentIdiopathic orbital inflammation1
3Not Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
3Not Yet RecruitingTreatmentOptic Neuropathy, Ischemic / Triamcinolone Acetonide1
3RecruitingPreventionProliferative Diabetic Retinopathy (PDR)1
3RecruitingSupportive CarePancreatitis, Chronic1
3RecruitingTreatmentBladder Pain Syndrome / Interstitial Cystitis1
3RecruitingTreatmentChalazion1
3RecruitingTreatmentEye Injury Trauma1
3RecruitingTreatmentInflammatory Macular Edema1
3RecruitingTreatmentKeloid Scars1
3RecruitingTreatmentLateral Epicondylitis1
3RecruitingTreatmentOther Abnormal Granulation Tissue Nos1
3TerminatedTreatmentGouty Arthritis1
3TerminatedTreatmentRhinitis1
3TerminatedTreatmentUveitis1
3Unknown StatusTreatmentDiabetes Mellitus / Macular Edema1
3Unknown StatusTreatmentDiabetic Macular Edema (DME)3
3Unknown StatusTreatmentDiffuse Diabetic Macular Edema1
3Unknown StatusTreatmentNeovascular Age-Related Macular Degeneration2
4Active Not RecruitingTreatmentArthritis of the Knee1
4Active Not RecruitingTreatmentExudative Retinal Detachment / Melanoma, Uveal1
4Active Not RecruitingTreatmentRadiculopathy, Cervical1
4Active Not RecruitingTreatmentWet Macular Degeneration1
4CompletedBasic ScienceTo Assess the Changes in Bone Mineral Density / To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject1
4CompletedOtherComplex Regional Pain Syndromes (CRPS) / Shoulder Hand Syndrome1
4CompletedPreventionEndophthalmitis Postoperative1
4CompletedPreventionRetinal Detachment / Retinoschisis / Vitreoretinopathy, Proliferative1
4CompletedSupportive CareOral Lichen Planus1
4CompletedTreatmentAdiposity1
4CompletedTreatmentAdrenal Insufficiency / Tendinopathy1
4CompletedTreatmentAlopecia Areata (AA)1
4CompletedTreatmentAtopic Dermatitis (AD)1
4CompletedTreatmentAtypical Facial Pain / Typical Facial Pain1
4CompletedTreatmentBack Pain Lower Back / Stenosis, Spinal1
4CompletedTreatmentDiabetic Macular Edema (DME)2
4CompletedTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
4CompletedTreatmentFat Reduction1
4CompletedTreatmentImpingement Shoulder1
4CompletedTreatmentKeloidscars1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)2
4CompletedTreatmentNasal Obstruction1
4CompletedTreatmentOphthalmopathy, Thyroid-Associated1
4CompletedTreatmentOral Lichen Planus1
4CompletedTreatmentOsteoarthritis (OA)2
4CompletedTreatmentOsteoarthritis (OA) of the Knee1
4CompletedTreatmentOsteoarthritis of the Hands1
4CompletedTreatmentPsoriatic Nails1
4CompletedTreatmentRhinitis, Allergic, Perennial1
4CompletedTreatmentRhinitis, Allergic, Perennial and/or Seasonal1
4CompletedTreatmentSinusitis1
4CompletedTreatmentTrigger Finger Disorder1
4Enrolling by InvitationTreatmentBack Pain Lower Back1
4Enrolling by InvitationTreatmentSacro-Iliac Spondylosis1
4Not Yet RecruitingTreatmentAlopecia Areata (AA)1
4Not Yet RecruitingTreatmentAlopecia Areata (AA) / Fractional Carbon Dioxide Laser1
4Not Yet RecruitingTreatmentChoroidal Effusions / Glaucoma1
4Not Yet RecruitingTreatmentExudative Age Related Macular Degeneration1
4Not Yet RecruitingTreatmentFunctional Performance / Physical Activity1
4Not Yet RecruitingTreatmentImpingement Shoulder / Osteoarthritis (OA) / Tendinopathy1
4Not Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
4Not Yet RecruitingTreatmentPain / Stroke1
4Not Yet RecruitingTreatmentVocal Nodules in Adults1
4RecruitingPreventionCataract Surgery1
4RecruitingTreatmentAtopic Dermatitis (AD) / Dermatitis, Eczematous1
4RecruitingTreatmentCentral Centrifugal Cicatricial Alopecia (CCCA)1
4RecruitingTreatmentCervical Radiculitis / Pain1
4RecruitingTreatmentFull Thickness Rotator Cuff Tear / Rotator Cuff Tendinitis1
4RecruitingTreatmentGlenohumeral Osteoarthritis1
4RecruitingTreatmentGout attack1
4RecruitingTreatmentHeadache1
4RecruitingTreatmentHypergranulation Tissue; Gastrostomy Tube Site1
4RecruitingTreatmentHypertrophic Scars / Scar Keloid1
4RecruitingTreatmentInflammatory Reaction / Intraocular Pressure1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)3
4RecruitingTreatmentKnee Replacement Surgery1
4RecruitingTreatmentLateral Epicondylitis1
4RecruitingTreatmentMorton's neuralgia1
4RecruitingTreatmentNail Diseases / Nail Psoriasis1
4RecruitingTreatmentPelvic Organ Prolapse (POP) / Postoperative pain / Sacrospinous Ligament Fixation / Trigger Point Injection1
4RecruitingTreatmentPsoriatic Arthritis1
4RecruitingTreatmentTrigger Finger1
4TerminatedPreventionKeloid Scars1
4TerminatedTreatmentAlopecia Areata (AA)1
4TerminatedTreatmentArthritis Multiple Joint / Basal Thumb Joint Arthritis / Basilar Joint Arthritis / Carpometacarpal Arthritis / Trapeziometacarpal Arthritis1
4TerminatedTreatmentAtopic Dermatitis (AD)1
4TerminatedTreatmentFemoroacetabular Impingement1
4TerminatedTreatmentLateral Epicondylitis1
4TerminatedTreatmentMyofascial Pain Syndrome1
4TerminatedTreatmentRadiculopathy, Cervical1
4TerminatedTreatmentShoulder Pain1
4Unknown StatusTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema1
4Unknown StatusTreatmentDermatitis, Contact / Dermatitis, Occupational1
4Unknown StatusTreatmentKeloid Scars1
4Unknown StatusTreatmentPainful Intercourse1
4WithdrawnTreatmentAbdominal Cutaneous Nerve Entrapment Syndrome / Chronic Abdominal Wall Pain1
4WithdrawnTreatmentCystoid Macular Edema / Uveitis1
4WithdrawnTreatmentDiabetes Mellitus / Rotator Cuff Injury / Rotator Cuff Syndrome / Rotator Cuff Tendinitis1
4WithdrawnTreatmentPsoriasis1
4WithdrawnTreatmentSpinal Stenosis of Lumbar Region1
Not AvailableActive Not RecruitingNot AvailableOsteoarthritis Thumb1
Not AvailableActive Not RecruitingOtherAsthma / Severe Persistent Asthma1
Not AvailableActive Not RecruitingTreatmentAcne1
Not AvailableActive Not RecruitingTreatmentCervical Disc Herniation / Pain, Neuropathic1
Not AvailableCompletedNot AvailableAnterior Uveitis (AU) / Chorioretinitis / Panuveitis / Uveitis / Uveitis, Intermediate1
Not AvailableCompletedNot AvailableInfiltration Facet Joint1
Not AvailableCompletedNot AvailableMalignant Neoplasm of Pancreas / Pancreatitis, Chronic1
Not AvailableCompletedNot AvailableOral Lichen Planus1
Not AvailableCompletedNot AvailablePain2
Not AvailableCompletedNot AvailableTrigger Finger1
Not AvailableCompletedBasic ScienceAcute Steroid Responsive Dermatoses / Chronic Steroid Responsive Dermatoses1
Not AvailableCompletedPreventionEsophageal Strictures1
Not AvailableCompletedPreventionMelanoma1
Not AvailableCompletedPreventionTracheal Intubation1
Not AvailableCompletedSupportive CareBlind Painful Eye / Control of Pain Through Drug Injection / Refractory Glaucoma1
Not AvailableCompletedTreatmentAdhesive Capsulitis1
Not AvailableCompletedTreatmentAdhesive Capsulitis of Shoulder1
Not AvailableCompletedTreatmentAlopecia Areata (AA)3
Not AvailableCompletedTreatmentBack Pain, Unspecified1
Not AvailableCompletedTreatmentBursitis1
Not AvailableCompletedTreatmentCarpal Tunnel Syndrome (CTS)3
Not AvailableCompletedTreatmentCataracts2
Not AvailableCompletedTreatmentCervial Disc Herniation / Cervical Disc Herniation / Prolapsed Lumbar Disc1
Not AvailableCompletedTreatmentCervical Spine1
Not AvailableCompletedTreatmentDiabetic Macular Edema (DME)2
Not AvailableCompletedTreatmentEye inflammation1
Not AvailableCompletedTreatmentGastric Adenoma / Malignant Neoplasm of Stomach1
Not AvailableCompletedTreatmentHidradenitis Suppurativa (HS)1
Not AvailableCompletedTreatmentKeloid Ear1
Not AvailableCompletedTreatmentKeloid Scars1
Not AvailableCompletedTreatmentKnee Osteoarthritis (Knee OA)1
Not AvailableCompletedTreatmentLateral Epicondylitis1
Not AvailableCompletedTreatmentLumbosacral Spondylosis / Radicular syndrome / Stenosis, Spinal1
Not AvailableCompletedTreatmentMacular Edema1
Not AvailableCompletedTreatmentMigraine1
Not AvailableCompletedTreatmentOsteoarthritis (OA)1
Not AvailableCompletedTreatmentPelvic Pain1
Not AvailableCompletedTreatmentPsoriasis1
Not AvailableCompletedTreatmentRotator Cuff Disease1
Not AvailableCompletedTreatmentRotator Cuff Impingement / Shoulder Pain1
Not AvailableCompletedTreatmentSacroiliitis1
Not AvailableCompletedTreatmentShoulder Pain / Subacromial Bursitis1
Not AvailableCompletedTreatmentShoulder Pain / Subacromial Bursitis / Subdeltoid Bursitis1
Not AvailableCompletedTreatmentSubacromial Bursitis1
Not AvailableCompletedTreatmentTrigger Finger1
Not AvailableCompletedTreatmentUlnar Neuropathy at Elbow1
Not AvailableEnrolling by InvitationTreatmentBreast Cancer Related Lymphedema / Lymphedema of Upper Limb1
Not AvailableNot Yet RecruitingNot AvailableDiabetes / Knee Osteoarthritis (Knee OA)1
Not AvailableNot Yet RecruitingTreatmentAutoimmune / Behcet's Syndrome1
Not AvailableNot Yet RecruitingTreatmentBurn Scars / Skin graft scar1
Not AvailableNot Yet RecruitingTreatmentCarpal Tunnel Syndrome (CTS) / Nerve Compression Syndromes / Peripheral Nervous System Diseases1
Not AvailableRecruitingNot AvailableAtopic Dermatitis (AD)1
Not AvailableRecruitingBasic ScienceAsthma, Allergic1
Not AvailableRecruitingDiagnosticCarpal Tunnel1
Not AvailableRecruitingTreatmentAdhesive Capsulitis1
Not AvailableRecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
Not AvailableRecruitingTreatmentGlaucoma1
Not AvailableRecruitingTreatmentCorticosteroid / Intralesional Injection / Treatments / Vitiligo1
Not AvailableRecruitingTreatmentKnee Osteoarthritis (Knee OA)1
Not AvailableRecruitingTreatmentPhysical Therapy / Rehabilitation / Subacromial Bursitis / Subacromial Impingement Syndrome / Therapeutic Exercise1
Not AvailableTerminatedTreatmentDermatitis, Eczematous1
Not AvailableTerminatedTreatmentLegg-Calve Perthes Disease1
Not AvailableTerminatedTreatmentLumbar and Other Intervertebral Disc Disorders With Radiculopathy1
Not AvailableTerminatedTreatmentOral Lichen Planus1
Not AvailableTerminatedTreatmentPancreatitis / Pancreatitis, Chronic1
Not AvailableUnknown StatusTreatmentAcne Keloidalis / AK / AKN / Dermatitis Papillaris Capillitii / Folliculitis Keloidalis Nuchae / Folliculitis Nuchae Scleroticans / Lichen Keloidalis Nuchae / NdYag Laser / Sycosis Framboesiformis1
Not AvailableUnknown StatusTreatmentAlopecia Areata (AA)1
Not AvailableUnknown StatusTreatmentRheumatoid Arthritis1
Not AvailableUnknown StatusTreatmentThyroid Diseases1
Not AvailableWithdrawnHealth Services ResearchAtopic Dermatitis (AD)1
Not AvailableWithdrawnTreatmentAdhesive Capsulitis1
Not AvailableWithdrawnTreatmentGlaucoma1
Not AvailableWithdrawnTreatmentMacular Degeneration1
Not AvailableWithdrawnTreatmentNeovascular Age-Related Macular Degeneration1
Not AvailableWithdrawnTreatmentSubacromial Bursitis / Subacromial Impingement Syndrome1

Pharmacoeconomics

Manufacturers
  • Astellas pharma us inc
  • Bristol myers squibb co
  • Barr laboratories inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Abbott laboratories
  • Sanofi aventis us llc
  • Ivax pharmaceuticals inc
  • Apothecon inc div bristol myers squibb
  • Solvay pharmaceuticals
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Altana inc
  • Ambix laboratories div organics corp america
  • G and w laboratories inc
  • Morton grove pharmaceuticals inc
  • Perrigo new york inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Taro pharmaceuticals inc
  • Taro pharmaceuticals usa inc
  • Topiderm inc
  • Vintage pharmaceuticals llc
  • Del ray laboratories inc
  • Savage laboratories inc div altana inc
  • Parnell pharmaceuticals inc
  • Sandoz canada inc
  • Allergan inc
  • Alcon inc
  • Bristol myers squibb co pharmaceutical research institute
  • Wockhardt eu operations (swiss) ag
  • Carolina medical products co
  • Lyne laboratories inc
  • Lupin atlantis holding sa switzerland
  • Ranbaxy laboratories inc
  • Akorn inc
Packagers
  • AAIPharma Inc.
  • Abbott Laboratories Ltd.
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • Alcon Laboratories
  • Armstrong Pharmaceuticals Inc.
  • A-S Medication Solutions LLC
  • Blansett Pharmacal Co. Inc.
  • Bristol-Myers Squibb Co.
  • C.O. Truxton Inc.
  • Carlisle Laboratories Inc.
  • Carolina Medical Products Co.
  • Clint Pharmaceutical Inc.
  • Crown Laboratories Inc.
  • Darby Dental Supply Co. Inc.
  • Del Ray Dermatology
  • Dept Health Central Pharmacy
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • E. Fougera and Co.
  • E.R. Squibb and Sons LLC
  • G & W Labs
  • Generics Puerto Rico Inc.
  • Genesis Pharmaceutical Inc.
  • Goldline Laboratories Inc.
  • Group Health Cooperative
  • H.J. Harkins Co. Inc.
  • Hl Moore Drug Exchange
  • Ide Interstate
  • Innoviant Pharmacy Inc.
  • Inyx Usa Ltd.
  • Keene Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Major Pharmaceuticals
  • Martica Enterprises Inc.
  • Martin Surgical Supply
  • Medisca Inc.
  • Medvantx Inc.
  • Mericon
  • Merit Pharmaceuticals
  • National Pharmaceuticals
  • Nycomed Inc.
  • Paddock Labs
  • Palmetto Pharmaceuticals Inc.
  • Parnell Pharmaceuticals Inc.
  • Perrigo Co.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Primedics Laboratories
  • Princeton Pharmaceutical Products Inc.
  • Qualitest
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Robar Inc.
  • San Jose Surgical Supply Inc.
  • Sandoz
  • Sanofi-Aventis Inc.
  • Savage Labs
  • Stat Rx Usa
  • Suppositoria Laboratories Inc.
  • Taro Pharmaceuticals USA
  • Topiderm Inc.
  • Vintage Pharmaceuticals Inc.
  • Watson Pharmaceuticals
  • Wockhardt Ltd.
  • X-Gen Pharmaceuticals
Dosage forms
FormRouteStrength
Spray, meteredNasal0.5 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral40 mg/1mL
SyrupOral
LiquidIntra-articular; Intramuscular; Intrasynovial
LiquidIntra-articular; Intradermal; Intramuscular
CreamTopical
TabletOral
Injection, suspensionIntra-articular; Parenteral20 mg/1mL
Injection, suspensionIntralesional; Parenteral5 mg/1mL
SuspensionIntra-articular20 mg
SuspensionIntra-articular
KitIntra-articular; Intramuscular40 mg/1mL
Aerosol, meteredRespiratory (inhalation)
Aerosol, meteredRespiratory (inhalation)75 ug/1
Kit
Kit1 mg/1g
EmulsionTopical
KitIntra-articular; Intralesional
KitIntra-articular; Intramuscular
Aerosol, sprayTopical0.147 mg/1g
LotionTopical0.25 mg/1mL
OintmentTopical5 mg/1g
Paste, dentifriceDental1 mg/1g
Injection, suspensionIntra-articular; Intralesional10 mg/1mL
Injection, suspensionIntra-articular; Intramuscular40 mg/1mL
Injection, suspensionIntramuscular40 mg/1mL
Injection, suspensionIntramuscular40 mg/1
Injection, suspensionIntra-articular; Intramuscular80 mg/1mL
KitTopical
ImplantSubcutaneous
Aerosol, meteredNasal
Aerosol, meteredNasal55 ug/1
Spray, meteredNasal55 mcg
Spray, meteredNasal
CreamTopical
OintmentTopical
PasteDental
OintmentBuccal1 mg/1g
GelTopical
KitInfiltration; Intramuscular
Injection, solutionIntra-articular; Intramuscular40 mg/1mL
KitEpidural; Infiltration
SuspensionIntramuscular
KitTopical1 mg/1g
OintmentTopical
CreamTopical0.025 mg/1g
CreamTopical0.1 mg/.1g
CreamTopical0.25 mg/1
CreamTopical0.25 mg/1g
CreamTopical1 mg/1g
CreamTopical1 mg/1
CreamTopical5 mg/1g
CreamTopical5 mg/1
Injection, suspensionIntra-articular; Intrabursal; Intradermal; Intralesional10 mg/1mL
Injection, suspensionIntra-articular; Intramuscular200 mg/5mL
Injection, suspensionIntra-articular; Intramuscular400 mg/10mL
LotionTopical1 mg/1mL
OintmentTopical0.1 mg/0.100g
OintmentTopical0.25 mg/1g
OintmentTopical0.5 mg/1g
OintmentTopical1 mg/1g
PasteDental1 mg/1g
PasteTopical1 mg/1g
SprayTopical0.147 mg/1g
Spray, meteredNasal55 ug/1
SuspensionIntra-articular; Intrabursal; Intradermal; Intrasynovial
SuspensionIntra-articular; Intrabursal; Intramuscular
SuspensionIntra-articular; Intramuscular
SuspensionIntralesional
SuspensionIntra-articular; Intradermal; Intralesional; Intramuscular
SuspensionIntra-articular; Intrasynovial; Periarticular
Injection, suspensionOphthalmic
SuspensionOphthalmic
Injection, suspensionOphthalmic40 mg/1mL
SuspensionIntravitreal40 mg
Injection, suspensionIntra-articular; Intramuscular; Intravitreal8 mg/0.1mL
KitIntra-articular32 mg/1
Prices
Unit descriptionCostUnit
Triesence 40 mg/ml vial148.8USD ml
Kenalog Aerosol 63 gm Can118.99USD can
Nasacort AQ 55 mcg/act Aerosol (Nasal Spray)118.74USD inhaler
Triamcinolone Acetonide 0.1% Paste 5 gm Tube71.7USD tube
Kenalog 0.5% Cream 20 gm Tube54.99USD tube
Kenalog 0.1% Lotion 60ml Bottle51.99USD bottle
Kenalog 0.025% Lotion 60ml Bottle46.99USD bottle
Triamcinolone Acetonide 0.025% Lotion 60ml Bottle40.99USD bottle
Triamcinolone diacetate powder26.01USD g
Triamcinolone powder20.29USD g
Kenalog 0.1% Cream 15 gm Tube18.99USD tube
Triamcinolone Acetonide 0.1% Ointment 80 gm Tube18.99USD tube
Triamcinolone Acetonide 0.5% Ointment 15 gm Tube14.99USD tube
Aristospan 20 mg/ml vial14.19USD ml
Oralone 0.1% paste13.57USD g
Triamcinolone Acetonide 0.025% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.1% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.5% Cream 15 gm Tube12.99USD tube
Triamcinolone Acetonide 0.025% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.025% Ointment 80 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Ointment 15 gm Tube11.99USD tube
Kenalog-40 40 mg/ml vial8.99USD ml
Triamcinolone acet 40 mg/ml sus8.42USD ml
Kenalog-40 40 mg/ml7.53USD ml
Nasacort aq nasal spray6.99USD g
Triamcinolone 0.1% paste6.4USD g
Triamcinolone Acetonide 40 mg/ml6.29USD ml
Triamcinolone Acetonide Usp 40 mg/ml5.76USD ml
Aristospan 5 mg/ml vial3.54USD ml
Kenalog-10 10 mg/ml3.24USD ml
Triamcinolone Acetonide 10 mg/ml2.71USD ml
Kenalog-10 10 mg/ml vial2.32USD ml
Triamcinolone acet 10 mg/ml sus2.18USD ml
Aristocort C 0.5 % Cream1.3USD g
Oracort 0.1 % Paste1.19USD g
Triderm 0.1% cream0.47USD g
Triamcinolone 0.5% cream0.22USD g
Aristocort R 0.1 % Cream0.15USD g
Aristocort R 0.1 % Ointment0.15USD g
Triamcinolone Acetonide 0.1% Cream0.07USD gm
Triaderm Regular 0.1 % Cream0.07USD g
Triamcinolone 0.025% cream0.06USD g
Triamcinolone Acetonide 0.1% Ointment0.05USD gm
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2268927No2003-09-232017-07-02Canada
US5976573No1999-11-022016-07-03Us
US6143329No2000-11-072016-07-03Us
US7977045No2011-07-122016-07-03Us
US6395294No2002-05-282020-01-13Us
US8211880No2012-07-032029-03-10Us
US8128960No2012-03-062029-12-17Us
US8828440No2014-09-092031-08-04Us
US9555048No2017-01-312031-08-04Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)270Chemspider
Predicted Properties
PropertyValueSource
Water Solubility0.847 mg/mLALOGPS
logP0.84ALOGPS
logP0.24ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)11.75ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area115.06 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity99.38 m3·mol-1ChemAxon
Polarizability39.79 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9823
Blood Brain Barrier+0.9528
Caco-2 permeable+0.7397
P-glycoprotein substrateSubstrate0.8204
P-glycoprotein inhibitor INon-inhibitor0.8759
P-glycoprotein inhibitor IINon-inhibitor0.9725
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8858
CYP450 2D6 substrateNon-substrate0.9006
CYP450 3A4 substrateSubstrate0.7049
CYP450 1A2 substrateNon-inhibitor0.9144
CYP450 2C9 inhibitorNon-inhibitor0.8939
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.911
CYP450 3A4 inhibitorNon-inhibitor0.9007
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.942
Ames testNon AMES toxic0.8858
CarcinogenicityNon-carcinogens0.9521
BiodegradationNot ready biodegradable0.9952
Rat acute toxicity2.3369 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9562
hERG inhibition (predictor II)Inhibitor0.6125
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (9.24 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-00di-2931000000-ee37afbf8c285181a340
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-006t-3970000000-70c8dcf068945a18ecdd
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 11-beta-hydroxysteroids / 16-alpha-hydroxysteroids / 17-hydroxysteroids / Halogenated steroids / 3-oxo delta-1,4-steroids / Delta-1,4-steroids / Tertiary alcohols / Alpha-hydroxy ketones
show 10 more
Substituents
Progestogin-skeleton / 21-hydroxysteroid / Pregnane-skeleton / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 9-halo-steroid / 17-hydroxysteroid / 16-hydroxysteroid / 11-hydroxysteroid
show 26 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 3-oxo Delta(4)-steroid, 20-oxo steroid, fluorinated steroid, 16alpha-hydroxy steroid, 21-hydroxy steroid, C21-steroid hormone (CHEBI:9667)

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Nehme A, Lobenhofer EK, Stamer WD, Edelman JL: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. [PubMed:19744340]
  2. Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [PubMed:16507850]
  3. Shahin V, Ludwig Y, Schafer C, Nikova D, Oberleithner H: Glucocorticoids remodel nuclear envelope structure and permeability. J Cell Sci. 2005 Jul 1;118(Pt 13):2881-9. [PubMed:15976447]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Dort K, Padia S, Wispelwey B, Moore CC: Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report. AIDS Res Ther. 2009 Jun 8;6:10. doi: 10.1186/1742-6405-6-10. [PubMed:19505306]
  2. Hagan JB, Erickson D, Singh RJ: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. Pain Med. 2010 Jul;11(7):1132-5. doi: 10.1111/j.1526-4637.2010.00852.x. Epub 2010 Apr 29. [PubMed:20456080]
  3. Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Schaefer EC, Stewart AA, Durgam SS, Byron CR, Stewart MC: Effects of sodium hyaluronate and triamcinolone acetonide on glucosaminoglycan metabolism in equine articular chondrocytes treated with interleukin-1. Am J Vet Res. 2009 Dec;70(12):1494-501. doi: 10.2460/ajvr.70.12.1494. [PubMed:19951121]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Identical protein binding
Specific Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name
BCHE
Uniprot ID
P06276
Uniprot Name
Cholinesterase
Molecular Weight
68417.575 Da
References
  1. Ehrich M, Jortner BS, Gross WB: Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens. Toxicol Appl Pharmacol. 1988 Feb;92(2):214-23. [PubMed:3341034]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [PubMed:20482443]
  2. Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS: Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. [PubMed:23143891]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS: Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. [PubMed:23143891]

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
General Function
Steroid binding
Specific Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name
SERPINA6
Uniprot ID
P08185
Uniprot Name
Corticosteroid-binding globulin
Molecular Weight
45140.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Groyer A, Le Bouc Y, Joab I, Radanyi C, Renoir JM, Robel P, Baulieu EE: Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor. Eur J Biochem. 1985 Jun 3;149(2):445-51. [PubMed:3996417]
  4. Svec F, Harrison RW: Conditions affecting AtT-20 cell glucocorticoid uptake. Steroids. 1981 Feb;37(2):143-56. [PubMed:7222146]
  5. Eisen HJ: An antiserum to the rat liver glucocorticoid receptor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3893-7. [PubMed:7001446]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. [PubMed:13700365]

Drug created on June 13, 2005 07:24 / Updated on March 30, 2020 22:56

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