Identification

Name
Triamcinolone
Accession Number
DB00620  (APRD00422)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Structure
Thumb
Synonyms
  • 11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
  • 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9α-fluoro-16α-hydroxyprednisolone
  • Fluoxyprednisolone
  • Tiamcinolonum
  • Triamcinolona
  • Triamcinolonum
Product Ingredients
IngredientUNIICASInChI Key
Triamcinolone acetonideF446C597KA76-25-5YNDXUCZADRHECN-JNQJZLCISA-N
Triamcinolone diacetateA73MM2Q32P67-78-7XGMPVBXKDAHORN-RBWIMXSLSA-N
Triamcinolone hexacetonideI7GT1U99Y95611-51-8TZIZWYVVGLXXFV-FLRHRWPCSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AllerNazeSpray, metered0.5 mg/1mLNasalLupin Pharmaceuticals2011-02-01Not applicableUs
AristocortInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Intrasynovial; ParenteralPhysicians Total Care, Inc.1961-09-052005-07-28Us
AristocortInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Intrasynovial; ParenteralSandoz1961-09-051961-09-05Us
Aristocort - Syr Orl 0.4mg/mlSyrup.4 mgOralGlades, Division Of Stiefel Canada Inc.1996-10-101997-08-05Canada
Aristocort - Tab 4mgTablet4 mgOralGlades, Division Of Stiefel Canada Inc.1998-05-112004-01-27Canada
Aristocort CCream0.5 %TopicalValeant Canada Lp Valeant Canada S.E.C.1997-10-21Not applicableCanada
Aristocort C Crm 0.5%Cream5 mgTopicalLederle Cyanamid Canada Inc.1965-12-311997-08-14Canada
Aristocort D - Crm Top 0.025%Cream.025 %TopicalGlades, Division Of Stiefel Canada Inc.1996-10-101998-07-09Canada
Aristocort D Crm 0.025%Cream.25 mgTopicalLederle Cyanamid Canada Inc.1974-12-311997-01-29Canada
Aristocort Forte - Liq Ia Im Isy 40mg/mlLiquid40 mgIntra-articular; Intramuscular; IntrasynovialGlades, Division Of Stiefel Canada Inc.1996-12-062000-12-04Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-triamcinolone AQSpray, metered55 mcgNasalApotex Corporation2016-06-15Not applicableCanada
DermacinRx TrizapakKit1 mg/1gPure Tek Corporation2016-08-022017-08-17Us
Dermasorb TA Complete KitKit1 mg/1gCrown Laboratories2013-11-14Not applicableUs
Juulissa PharmapakKit1 mg/1gPure Tek Corporation2016-12-28Not applicableUs
KenalogOintment5 mg/1gTopicalE.R. Squibb & Sons, L.L.C.2007-01-012007-08-31Us
KenalogLotion1 mg/1mLTopicalE.R. Squibb & Sons, L.L.C.2007-01-012007-12-31Us
KenalogLotion0.25 mg/1mLTopicalE.R. Squibb & Sons, L.L.C.2005-01-012005-03-31Us
OralonePaste1 mg/1gDentalTaro Pharmaceuticals U.S.A., Inc.1986-10-01Not applicableUs
Pediaderm TAKit1 mg/1gArbor Pharmaceuticals2011-01-012015-10-31Us
Pediaderm TACream1 mg/1gTopicalArbor Pharmaceuticals2010-09-01Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Nasal AllergySpray, metered55 ug/1NasalMeijer Distribution Inc2017-01-18Not applicableUs
24 Hour Nasal AllergySpray, metered55 ug/1NasalKroger2016-04-10Not applicableUs
Allergy NasalSpray, metered55 ug/1NasalWalgreen2016-04-10Not applicableUs
Basic Care Nasal AllergySpray, metered55 ug/1NasalL. Perrigo Company2018-04-25Not applicableUs
CareOne Allergy ReliefSpray, metered55 ug/1NasalAmerican Sales Company2017-06-12Not applicableUs
Childrens Nasacort Allergy 24HRSpray, metered55 ug/1NasalChattem, Inc.2015-07-01Not applicableUs
Childrens Nasal AllergySpray, metered55 ug/1NasalCVS PHARMACY2018-06-28Not applicableUs
Equaline nasal allergySpray, metered55 ug/1NasalSupervalu2016-12-29Not applicableUs
Equate Nasal AllergySpray, metered55 ug/1NasalWalmart Stores2016-04-17Not applicableUs
Good Neighbor Pharmacy 24 Hour Nasal AllergySpray, metered55 ug/1NasalAmerisource Bergen2016-10-24Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Aristoform R Crm 0.1%Triamcinolone acetonide (1 mg) + Clioquinol (30 mg)CreamTopicalLederle Cyanamid Canada Inc.1966-12-311997-01-29Canada
BtTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Isopropyl Alcohol (0.7 mL/1) + Povidone-iodine (0.10 g/1)KitSa3, Llc2015-07-01Not applicableUs
Cortaren Corticosteroid/Anti-Inflammatory SystemTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Dexamethasone sodium phosphate (4 mg/1mL) + Isopropyl Alcohol (0.7 mL/1mL)KitIt3 Medical Llc2017-03-01Not applicableUs
DermacinRx Cinlone-I CPITriamcinolone acetonide (40 mg/1mL) + Lidocaine (25 mg/1g) + Prilocaine (25 mg/1g)KitPure Tek Corporation2016-05-17Not applicableUs
DermacinRx Cinlone-II CPITriamcinolone acetonide (40 mg/1mL) + Lidocaine (25 mg/1g) + Prilocaine (25 mg/1g)KitPure Tek Corporation2016-06-24Not applicableUs
DermacinRx SilaPakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitNucare Pharmaceuticals,inc.2015-08-18Not applicableUs
DermacinRx SilaPakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitPure Tek Corporation2015-08-18Not applicableUs
Dermasilkrx SDSpakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitPatchwerx Labs2015-07-20Not applicableUs
Dermawerx SDS PakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitPatchwerx Labs2015-07-20Not applicableUs
Ellzia PakTriamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)KitPure Tek Corporation2016-12-29Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AzmacortTriamcinolone acetonide (75 ug/1)Aerosol, meteredRespiratory (inhalation)Kos Pharmaceuticals, Inc.2007-08-032007-08-03Us
Bupivilog KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
Interarticular Joint KitTriamcinolone acetonide (40 mg/1mL) + Ammonia (0.045 g/0.3mL) + Lidocaine hydrochloride anhydrous (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); TopicalAsclemed Usa, Inc.2014-02-052015-06-19Us
Lidolog KitTriamcinolone acetonide (40 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2018-05-10Not applicableUs
MLK F1 KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; IntramuscularAsclemed Usa, Inc.2014-01-16Not applicableUs
MLK F3 KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Lidocaine hydrochloride anhydrous (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
MLK F4 KitTriamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2009-06-01Not applicableUs
MLK Kit F2Triamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2018-05-10Not applicableUs
NaltrexoneTriamcinolone (6.5 mg/1) + Naltrexone (200 mg/1)ImplantSubcutaneousComplete Pharmacy And Medical Solutions2018-02-01Not applicableUs
NasacortTriamcinolone acetonide (55 ug/1)Aerosol, meteredNasalAventis Pharmaceuticals Inc.2006-09-07Not applicableUs
International/Other Brands
Aristocort / Delphicort / Flutex / Kenacort / Omcilon-A / Oracort / Tri-Nasal / Triacet / Triacort / Triaderm / Tricortone / Trilone / Tristoject
Categories
UNII
1ZK20VI6TY
CAS number
124-94-7
Weight
Average: 394.4339
Monoisotopic: 394.179166801
Chemical Formula
C21H27FO6
InChI Key
GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
IUPAC Name
(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
SMILES
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Pharmacology

Indication

For the treatment of perennial and seasonal allergic rhinitis.

Associated Conditions
Pharmacodynamics

Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

Mechanism of action

The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Human
Absorption

Rapid absorption following oral administration

Volume of distribution
Not Available
Protein binding

68%

Metabolism

Hepatic.

Route of elimination
Not Available
Half life

88 minutes

Clearance
Not Available
Toxicity

LD50=>500mg/kg (in rats)

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Triamcinolone.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Triamcinolone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Triamcinolone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Triamcinolone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Triamcinolone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Triamcinolone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Triamcinolone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Triamcinolone.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Triamcinolone.
Food Interactions
Not Available

References

Synthesis Reference

Abu Alam, "Triamcinolone formulations and methods for their preparation and use." U.S. Patent US20040186084, issued September 23, 2004.

US20040186084
General References
Not Available
External Links
Human Metabolome Database
HMDB0014758
KEGG Drug
D00385
PubChem Compound
31307
PubChem Substance
46507950
ChemSpider
29046
BindingDB
41132
ChEBI
9667
ChEMBL
CHEMBL1451
Therapeutic Targets Database
DAP000417
PharmGKB
PA451749
IUPHAR
2870
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Triamcinolone
ATC Codes
R01AD11 — TriamcinoloneD07BB03 — Triamcinolone and antisepticsD07CB01 — Triamcinolone and antibioticsS02CA04 — Triamcinolone and antiinfectivesC05AA12 — TriamcinoloneH02AB08 — TriamcinoloneS01BA05 — TriamcinoloneD07AB09 — TriamcinoloneD07XB02 — TriamcinoloneA01AC01 — TriamcinoloneR03BA06 — Triamcinolone
AHFS Codes
  • 68:04.00 — Adrenals
  • 84:06.00 — Anti-inflammatory Agents
  • 52:08.08 — Corticosteroids
FDA label
Download (150 KB)
MSDS
Download (72.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticRetinopathy, Diabetic1
0Unknown StatusTreatmentGreater Trochanteric Pain Syndrome1
1CompletedTreatmentCystoid Macular Edema1
1CompletedTreatmentDiabetic Macular Edema (DME)1
1CompletedTreatmentMacular Degeneration / Retinal Vein Occlusions(RVO)1
1CompletedTreatmentMacular Degeneration / Retinal Vein Occlusions(RVO) / Retinopathy, Diabetic1
1RecruitingTreatmentFibromatosis1
1TerminatedDiagnosticFibrosis1
1TerminatedTreatmentRotator Cuff Syndrome1
1Unknown StatusTreatmentCystoid Macular Edema / Uveitis1
1Unknown StatusTreatmentDiabetic Macular Edema (DME) / Retinopathy, Diabetic1
1, 2CompletedSupportive CareMucositis1
1, 2CompletedTreatmentAge-Related Macular Degeneration (ARMD) / Subfoveal Choroidal Neovascularization1
1, 2CompletedTreatmentDiabetic Macular Edema (DME)1
1, 2CompletedTreatmentDiffuse posterior uveitis / Noninfectious Uveitis / Panuveitis / Uveitis / Uveitis, Intermediate1
1, 2TerminatedTreatmentPolyps, Nasal1
1, 2Unknown StatusTreatmentAcute Nonarteritic Anterior Ischemic Optic Neuropathy1
1, 2Unknown StatusTreatmentDiabetic Macular Edema (DME)1
1, 2Unknown StatusTreatmentRetinopathy, Diabetic2
2Active Not RecruitingTreatmentAcute Gouty Arthritis1
2Active Not RecruitingTreatmentBilateral Knee Osteoarthritis1
2Active Not RecruitingTreatmentOsteoarthritis of the Hip / Osteoarthritis of the Shoulder1
2CompletedBasic ScienceDiabetic Macular Edema (DME)1
2CompletedScreeningAlopecia Areata (AA)1
2CompletedTreatmentAcute Gouty Arthritis1
2CompletedTreatmentAge-Related Macular Degeneration (ARMD)1
2CompletedTreatmentAlcohol Use Disorder (AUD) / Major Depressive Disorder (MDD)1
2CompletedTreatmentAnterior Cruciate Ligament (ACL) Tears1
2CompletedTreatmentAtopic Dermatitis (AD)2
2CompletedTreatmentBranch Retinal Vein Occlusion1
2CompletedTreatmentDiabetic Macular Edema (DME)4
2CompletedTreatmentKnee Osteoarthritis (Knee OA)4
2CompletedTreatmentKnee Osteoarthritis (Knee OA) / Type 2 Diabetes Mellitus1
2CompletedTreatmentNon-Melanomatous Skin Cancer / Precancerous/Nonmalignant Condition1
2CompletedTreatmentOral Lichen Planus1
2CompletedTreatmentShoulder Pain1
2Not Yet RecruitingTreatmentErosive Oral Lichen Planus1
2RecruitingPreventionAcneiform Rash / Papulopustular Eruption1
2RecruitingSupportive CareCutaneous T-Cell Lymphoma (CTCL) / Cutaneous T-cell Lymphoma Stage I / Folliculotropic Mycosis Fungoides / Granulomatous Slack Skin / Mycosis Fungoides (MF) / Mycosis Fungoides Variant / Syringotropic Mycosis Fungoides / Transformed Mycosis Fungoides1
2RecruitingTreatmentAbdominal Pain (AP)1
2RecruitingTreatmentDry Eye Syndrome (DES)1
2RecruitingTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
2RecruitingTreatmentVitiligo1
2TerminatedTreatmentMacular Edema (ME)1
2TerminatedTreatmentPost-traumatic Osteoarthritis of the Knee1
2Unknown StatusTreatmentBranch Retinal Vein Occlusion1
2Unknown StatusTreatmentCentral Retinal Vein Occlusion (CRVO)1
2Unknown StatusTreatmentRetinopathy, Diabetic1
2Unknown StatusTreatmentRetinovascular Disease1
2Unknown StatusTreatmentShoulder Pain1
2Unknown StatusTreatmentWet Macular Degeneration1
2WithdrawnTreatmentMacular Edema (ME) / Uveitis1
2, 3CompletedTreatmentDiabetic Macular Edema (DME) / Macular Edema (ME)1
2, 3CompletedTreatmentGlaucoma1
2, 3Not Yet RecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
2, 3Not Yet RecruitingTreatmentFlail Chest1
2, 3RecruitingTreatmentChronic Rhinosinusitis / Polyps, Nasal1
2, 3RecruitingTreatmentKnee Arthritis1
2, 3RecruitingTreatmentProliferative Diabetic Retinopathy (PDR)1
2, 3RecruitingTreatmentTrigger Digit1
2, 3RecruitingTreatmentVitiligo1
2, 3SuspendedTreatmentMelasma1
2, 3Unknown StatusTreatmentAge-Related Macular Degeneration (ARMD)1
2, 3Unknown StatusTreatmentUveal Melanoma1
3Active Not RecruitingTreatmentAdhesive Capsulitis of Shoulder / Shoulder Adhesive Capsulitis / Shoulder Capsulitis1
3Active Not RecruitingTreatmentAnterior Uveitis (AU) / Diffuse posterior uveitis / Panuveitis / Uveitis / Uveitis, Intermediate1
3CompletedPreventionCataracts / Cystoid Macular Edema / Diabetes Mellitus (DM)1
3CompletedTreatmentAcute Gouty Arthritis3
3CompletedTreatmentAllergic Rhinitis (AR)1
3CompletedTreatmentAnterior Uveitis (AU) / Diffuse posterior uveitis / Panuveitis / Uveitis / Uveitis, Intermediate1
3CompletedTreatmentChronic Lung Diseases / Chronic Obstructive Pulmonary Disease (COPD) / Lung Diseases, Obstructive1
3CompletedTreatmentDiabetic Macular Edema (DME) / DME / Retinopathy, Diabetic1
3CompletedTreatmentDiabetic Macular Edema (DME)2
3CompletedTreatmentDiabetic Macular Edema (DME) / Proliferative Diabetic Retinopathy (PDR)1
3CompletedTreatmentDupuytren's Contracture1
3CompletedTreatmentKnee Osteoarthritis (Knee OA)3
3CompletedTreatmentMacular Degeneration1
3CompletedTreatmentMacular Degeneration / Subfoveal Choroidal Neovascularization1
3CompletedTreatmentMacular Edema (ME) / Macular Edema, Cystoid / Retinal Vein Occlusions(RVO)1
3CompletedTreatmentMacular Edema (ME) / Retinopathy, Diabetic1
3CompletedTreatmentMacular Edema (ME) / Uveitis1
3CompletedTreatmentNegative Middle Ear Pressure / Otitis Media, Serous / Rhinitis1
3CompletedTreatmentOral Lichen Planus1
3CompletedTreatmentOral Pemphigus Vulgaris1
3CompletedTreatmentOsteoarthritis (OA)1
3CompletedTreatmentPancreatitis, Chronic1
3CompletedTreatmentRadicular syndrome1
3CompletedTreatmentRetinal Vein Occlusions(RVO)1
3CompletedTreatmentRhinitis, Allergic, Perennial1
3CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
3CompletedTreatmentVitrectomy therapy1
3CompletedTreatmentVitreoretinopathy, Proliferative1
3Enrolling by InvitationTreatmentKnee Osteoarthritis (Knee OA)1
3Not Yet RecruitingTreatmentOptic Neuropathy, Ischemic / Triamcinolone Acetonide1
3RecruitingPreventionProliferative Diabetic Retinopathy (PDR)1
3RecruitingTreatmentChalazion1
3RecruitingTreatmentEye Injury Trauma1
3RecruitingTreatmentInflammatory Macular Edema1
3RecruitingTreatmentKeloid Scars1
3RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
3RecruitingTreatmentLateral Epicondylitis1
3RecruitingTreatmentOther Abnormal Granulation Tissue Nos1
3TerminatedTreatmentAcute Gouty Arthritis1
3TerminatedTreatmentRhinitis1
3TerminatedTreatmentUveitis1
3Unknown StatusTreatmentDiabetic Macular Edema (DME)3
3Unknown StatusTreatmentDiffuse Diabetic Macular Edema1
4Active Not RecruitingTreatmentArthritis of the Knee1
4Active Not RecruitingTreatmentExudative Retinal Detachment / Uveal Melanoma1
4CompletedBasic ScienceTo Assess the Changes in Bone Mineral Density / To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject1
4CompletedPreventionRetinal Detachment / Retinoschisis / Vitreoretinopathy, Proliferative1
4CompletedSupportive CareOral Lichen Planus1
4CompletedTreatmentAdrenal Insufficiency / Tendinopathy1
4CompletedTreatmentAlcohol Dependence1
4CompletedTreatmentAlopecia Areata (AA)1
4CompletedTreatmentAtopic Dermatitis (AD)2
4CompletedTreatmentAtypical Facial Pain / Typical Facial Pain1
4CompletedTreatmentDiabetic Macular Edema (DME)2
4CompletedTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
4CompletedTreatmentFat Reduction1
4CompletedTreatmentImpingement Shoulder1
4CompletedTreatmentKeloidscars1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)1
4CompletedTreatmentOral Lichen Planus1
4CompletedTreatmentOsteoarthritis (OA)2
4CompletedTreatmentOsteoarthritis (OA) of the Knee1
4CompletedTreatmentSinusitis1
4CompletedTreatmentTrigger Finger Disorder1
4Enrolling by InvitationTreatmentSacro-Iliac Spondylosis1
4Not Yet RecruitingTreatmentAcute Gouty Arthritis1
4Not Yet RecruitingTreatmentAlopecia Areata (AA)1
4Not Yet RecruitingTreatmentCystoid Macular Edema / Uveitis1
4Not Yet RecruitingTreatmentDiabetes Mellitus (DM) / Rotator Cuff Injury / Rotator Cuff Syndrome / Rotator Cuff Tendinitis1
4Not Yet RecruitingTreatmentFunctional Performance / Physical Activity1
4Not Yet RecruitingTreatmentPain / Strokes1
4Not Yet RecruitingTreatmentRadiculopathy, Cervical2
4RecruitingOtherComplex Regional Pain Syndromes (CRPS) / Shoulder Hand Syndrome1
4RecruitingPreventionCataract operation1
4RecruitingTreatmentAdiposity1
4RecruitingTreatmentAlopecia Areata (AA)1
4RecruitingTreatmentChoroidal Effusions / Glaucoma1
4RecruitingTreatmentGlenohumeral Osteoarthritis1
4RecruitingTreatmentHeadaches1
4RecruitingTreatmentHypergranulation Tissue; Gastrostomy Tube Site1
4RecruitingTreatmentInflammatory Reaction / Intraocular Pressure1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)3
4RecruitingTreatmentLateral Epicondylitis1
4RecruitingTreatmentNasal Obstruction1
4RecruitingTreatmentOpioid-use Disorder1
4RecruitingTreatmentWet Macular Degeneration1
4TerminatedTreatmentArthritis Multiple Joint / Basal Thumb Joint Arthritis / Basilar Joint Arthritis / Carpometacarpal Arthritis / Trapeziometacarpal Arthritis1
4TerminatedTreatmentShoulder Pain1
4Unknown StatusTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME)1
4Unknown StatusTreatmentDermatitis, Contact / Dermatitis, Occupational1
4Unknown StatusTreatmentKeloid Scars1
4WithdrawnTreatmentAbdominal Cutaneous Nerve Entrapment Syndrome / Chronic Abdominal Wall Pain1
4WithdrawnTreatmentPsoriasis1
Not AvailableActive Not RecruitingNot AvailableOsteoarthritis Thumb1
Not AvailableActive Not RecruitingOtherAsthma Bronchial / Severe Persistent Asthma1
Not AvailableActive Not RecruitingTreatmentAcne1
Not AvailableActive Not RecruitingTreatmentCervical Spine1
Not AvailableActive Not RecruitingTreatmentLumbosacral Spondylosis / Radicular syndrome / Spinal Stenosis1
Not AvailableActive Not RecruitingTreatmentPelvic Pain1
Not AvailableCompletedNot AvailableMalignant Neoplasm of Pancreas / Pancreatitis, Chronic1
Not AvailableCompletedNot AvailablePain1
Not AvailableCompletedNot AvailableTrigger Finger1
Not AvailableCompletedBasic ScienceAcute Steroid Responsive Dermatoses / Chronic Steroid Responsive Dermatoses1
Not AvailableCompletedPreventionBMI >27 kg/m2 / BMI >30 kg/m2 / Cancer, Breast1
Not AvailableCompletedPreventionTracheal Intubation1
Not AvailableCompletedSupportive CareBlind Painful Eye / Control of Pain Through Drug Injection / Refractory Glaucoma1
Not AvailableCompletedTreatmentAdhesive Capsulitis1
Not AvailableCompletedTreatmentAlopecia Areata (AA)3
Not AvailableCompletedTreatmentBack Pain1
Not AvailableCompletedTreatmentBursitis1
Not AvailableCompletedTreatmentCarpal Tunnel Syndrome (CTS)1
Not AvailableCompletedTreatmentCarpal Tunnel Syndrome (CTS) / Pain, Chronic1
Not AvailableCompletedTreatmentCataracts1
Not AvailableCompletedTreatmentCervial Disc Herniation / Cervical Disc Herniation / Prolapsed Lumbar Disc1
Not AvailableCompletedTreatmentDiabetic Macular Edema (DME)2
Not AvailableCompletedTreatmentHidradenitis Suppurativa (HS)1
Not AvailableCompletedTreatmentKeloid Ear1
Not AvailableCompletedTreatmentKnee Osteoarthritis (Knee OA)1
Not AvailableCompletedTreatmentLateral Epicondylitis1
Not AvailableCompletedTreatmentMigraines1
Not AvailableCompletedTreatmentOsteoarthritis (OA)1
Not AvailableCompletedTreatmentRotator Cuff Disease1
Not AvailableCompletedTreatmentSacroiliitis1
Not AvailableCompletedTreatmentShoulder Pain / Subacromial Bursitis1
Not AvailableCompletedTreatmentShoulder Pain / Subacromial Bursitis / Subdeltoid Bursitis1
Not AvailableCompletedTreatmentSubacromial Bursitis1
Not AvailableCompletedTreatmentTrigger Finger1
Not AvailableCompletedTreatmentOcular inflammatory conditions1
Not AvailableRecruitingNot AvailablePain1
Not AvailableRecruitingBasic ScienceAsthma, Allergic1
Not AvailableRecruitingDiagnosticCarpal Tunnel1
Not AvailableRecruitingTreatmentCarpal Tunnel Syndrome (CTS)2
Not AvailableRecruitingTreatmentKnee Osteoarthritis (Knee OA)1
Not AvailableTerminatedTreatmentDermatitis, Eczematous1
Not AvailableTerminatedTreatmentLegg-Calve Perthes Disease1
Not AvailableTerminatedTreatmentLumbar and Other Intervertebral Disc Disorders With Radiculopathy1
Not AvailableTerminatedTreatmentOral Lichen Planus1
Not AvailableTerminatedTreatmentPancreatitis / Pancreatitis, Chronic1
Not AvailableUnknown StatusTreatmentAcne Keloidalis / AK / AKN / Dermatitis Papillaris Capillitii / Folliculitis Keloidalis Nuchae / Folliculitis Nuchae Scleroticans / Lichen Keloidalis Nuchae / NdYag Laser / Sycosis Framboesiformis1
Not AvailableUnknown StatusTreatmentAlopecia Areata (AA)1
Not AvailableUnknown StatusTreatmentGlaucoma1
Not AvailableUnknown StatusTreatmentRheumatoid Arthritis1
Not AvailableUnknown StatusTreatmentThyroid Diseases1
Not AvailableWithdrawnHealth Services ResearchAtopic Dermatitis (AD)1
Not AvailableWithdrawnTreatmentAdhesive Capsulitis1
Not AvailableWithdrawnTreatmentMacular Degeneration1
Not AvailableWithdrawnTreatmentNeovascular Age-Related Macular Degeneration1
Not AvailableWithdrawnTreatmentSubacromial Bursitis / Subacromial Impingement Syndrome1

Pharmacoeconomics

Manufacturers
  • Astellas pharma us inc
  • Bristol myers squibb co
  • Barr laboratories inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Abbott laboratories
  • Sanofi aventis us llc
  • Ivax pharmaceuticals inc
  • Apothecon inc div bristol myers squibb
  • Solvay pharmaceuticals
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Altana inc
  • Ambix laboratories div organics corp america
  • G and w laboratories inc
  • Morton grove pharmaceuticals inc
  • Perrigo new york inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Taro pharmaceuticals inc
  • Taro pharmaceuticals usa inc
  • Topiderm inc
  • Vintage pharmaceuticals llc
  • Del ray laboratories inc
  • Savage laboratories inc div altana inc
  • Parnell pharmaceuticals inc
  • Sandoz canada inc
  • Allergan inc
  • Alcon inc
  • Bristol myers squibb co pharmaceutical research institute
  • Wockhardt eu operations (swiss) ag
  • Carolina medical products co
  • Lyne laboratories inc
  • Lupin atlantis holding sa switzerland
  • Ranbaxy laboratories inc
  • Akorn inc
Packagers
  • AAIPharma Inc.
  • Abbott Laboratories Ltd.
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • Alcon Laboratories
  • Armstrong Pharmaceuticals Inc.
  • A-S Medication Solutions LLC
  • Blansett Pharmacal Co. Inc.
  • Bristol-Myers Squibb Co.
  • C.O. Truxton Inc.
  • Carlisle Laboratories Inc.
  • Carolina Medical Products Co.
  • Clint Pharmaceutical Inc.
  • Crown Laboratories Inc.
  • Darby Dental Supply Co. Inc.
  • Del Ray Dermatology
  • Dept Health Central Pharmacy
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • E. Fougera and Co.
  • E.R. Squibb and Sons LLC
  • G & W Labs
  • Generics Puerto Rico Inc.
  • Genesis Pharmaceutical Inc.
  • Goldline Laboratories Inc.
  • Group Health Cooperative
  • H.J. Harkins Co. Inc.
  • Hl Moore Drug Exchange
  • Ide Interstate
  • Innoviant Pharmacy Inc.
  • Inyx Usa Ltd.
  • Keene Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Major Pharmaceuticals
  • Martica Enterprises Inc.
  • Martin Surgical Supply
  • Medisca Inc.
  • Medvantx Inc.
  • Mericon
  • Merit Pharmaceuticals
  • National Pharmaceuticals
  • Nycomed Inc.
  • Paddock Labs
  • Palmetto Pharmaceuticals Inc.
  • Parnell Pharmaceuticals Inc.
  • Perrigo Co.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Primedics Laboratories
  • Princeton Pharmaceutical Products Inc.
  • Qualitest
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Robar Inc.
  • San Jose Surgical Supply Inc.
  • Sandoz
  • Sanofi-Aventis Inc.
  • Savage Labs
  • Stat Rx Usa
  • Suppositoria Laboratories Inc.
  • Taro Pharmaceuticals USA
  • Topiderm Inc.
  • Vintage Pharmaceuticals Inc.
  • Watson Pharmaceuticals
  • Wockhardt Ltd.
  • X-Gen Pharmaceuticals
Dosage forms
FormRouteStrength
Spray, meteredNasal0.5 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral40 mg/1mL
SyrupOral.4 mg
CreamTopical0.5 %
CreamTopical5 mg
CreamTopical.025 %
CreamTopical.25 mg
LiquidIntra-articular; Intramuscular; Intrasynovial40 mg
LiquidIntra-articular; Intradermal; Intramuscular25 mg
CreamTopical1 mg
OintmentTopical.1 %
SyrupOral2 mg
TabletOral2 mg
TabletOral4 mg
Injection, suspensionIntra-articular; Parenteral20 mg/1mL
Injection, suspensionIntralesional; Parenteral5 mg/1mL
SuspensionIntra-articular20 mg
Aerosol, meteredRespiratory (inhalation)200 mcg
Aerosol, meteredRespiratory (inhalation)75 ug/1
KitEpidural; Intra-articular; Intramuscular; Topical
Kit1 mg/1g
KitEpidural; Infiltration; Intra-articular; Intralesional
Aerosol, sprayTopical0.147 mg/1g
OintmentTopical5 mg/1g
Paste, dentifriceDental1 mg/1g
PasteDental1 mg
OintmentTopical1 mg
Injection, suspensionIntra-articular; Intralesional10 mg/1mL
SuspensionIntra-articular; Intrabursal; Intradermal; Intrasynovial10 mg
Injection, suspensionIntra-articular; Intramuscular40 mg/1mL
Injection, suspensionIntramuscular40 mg/1
Injection, suspensionIntramuscular40 mg/1mL
SuspensionIntra-articular; Intramuscular40 mg
Kit
ImplantSubcutaneous
Aerosol, meteredNasal100 mcg
Aerosol, meteredNasal55 ug/1
Spray, meteredNasal55 mcg
PasteDental.1 %
PasteDental1 mg/1g
KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
KitInfiltration; Soft tissue; Topical
KitEpidural; Infiltration; Intra-articular; Intramuscular
KitIntra-articular; Intramuscular40 mg/1mL
Injection, solutionIntra-articular; Intramuscular40 mg/1mL
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
SuspensionIntramuscular40 mg
CreamTopical
CreamTopical0.1 %
OintmentTopical0.25 mg
OintmentTopical0.1 %
CreamTopical0.025 mg/1g
CreamTopical0.1 mg/.1g
CreamTopical0.25 mg/1g
CreamTopical0.25 mg/1
CreamTopical1 mg/1
CreamTopical1 mg/1g
CreamTopical5 mg/1
CreamTopical5 mg/1g
Injection, suspensionIntra-articular; Intrabursal; Intradermal; Intralesional10 mg/1mL
Injection, suspensionIntra-articular; Intramuscular200 mg/5mL
Injection, suspensionIntra-articular; Intramuscular400 mg/10mL
LotionTopical0.25 mg/1mL
LotionTopical1 mg/1mL
OintmentTopical0.1 mg/0.100g
OintmentTopical0.25 mg/1g
OintmentTopical0.5 mg/1g
OintmentTopical1 mg/1g
PasteTopical1 mg/1g
SprayTopical0.147 mg/1g
Spray, meteredNasal55 ug/1
SuspensionIntra-articular; Intrabursal; Intramuscular40 mg
SuspensionIntralesional40 mg
SuspensionIntra-articular; Intradermal; Intralesional; Intramuscular40 mg
SuspensionIntra-articular; Intrasynovial; Periarticular20 mg
Injection, suspensionOphthalmic
SuspensionOphthalmic
Injection, suspensionOphthalmic40 mg/1mL
SuspensionIntravitreal40 mg
Injection, suspensionIntra-articular; Intramuscular; Intravitreal8 mg/0.1mL
OintmentTopical
KitIntra-articular32 mg/1
Prices
Unit descriptionCostUnit
Triesence 40 mg/ml vial148.8USD ml
Kenalog Aerosol 63 gm Can118.99USD can
Nasacort AQ 55 mcg/act Aerosol (Nasal Spray)118.74USD inhaler
Triamcinolone Acetonide 0.1% Paste 5 gm Tube71.7USD tube
Kenalog 0.5% Cream 20 gm Tube54.99USD tube
Kenalog 0.1% Lotion 60ml Bottle51.99USD bottle
Kenalog 0.025% Lotion 60ml Bottle46.99USD bottle
Triamcinolone Acetonide 0.025% Lotion 60ml Bottle40.99USD bottle
Triamcinolone diacetate powder26.01USD g
Triamcinolone powder20.29USD g
Kenalog 0.1% Cream 15 gm Tube18.99USD tube
Triamcinolone Acetonide 0.1% Ointment 80 gm Tube18.99USD tube
Triamcinolone Acetonide 0.5% Ointment 15 gm Tube14.99USD tube
Aristospan 20 mg/ml vial14.19USD ml
Oralone 0.1% paste13.57USD g
Triamcinolone Acetonide 0.025% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.1% Cream 80 gm Tube12.99USD tube
Triamcinolone Acetonide 0.5% Cream 15 gm Tube12.99USD tube
Triamcinolone Acetonide 0.025% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.025% Ointment 80 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Cream 15 gm Tube11.99USD tube
Triamcinolone Acetonide 0.1% Ointment 15 gm Tube11.99USD tube
Kenalog-40 40 mg/ml vial8.99USD ml
Triamcinolone acet 40 mg/ml sus8.42USD ml
Kenalog-40 40 mg/ml7.53USD ml
Nasacort aq nasal spray6.99USD g
Triamcinolone 0.1% paste6.4USD g
Triamcinolone Acetonide 40 mg/ml6.29USD ml
Triamcinolone Acetonide Usp 40 mg/ml5.76USD ml
Aristospan 5 mg/ml vial3.54USD ml
Kenalog-10 10 mg/ml3.24USD ml
Triamcinolone Acetonide 10 mg/ml2.71USD ml
Kenalog-10 10 mg/ml vial2.32USD ml
Triamcinolone acet 10 mg/ml sus2.18USD ml
Aristocort C 0.5 % Cream1.3USD g
Oracort 0.1 % Paste1.19USD g
Triderm 0.1% cream0.47USD g
Triamcinolone 0.5% cream0.22USD g
Aristocort R 0.1 % Cream0.15USD g
Aristocort R 0.1 % Ointment0.15USD g
Triamcinolone Acetonide 0.1% Cream0.07USD gm
Triaderm Regular 0.1 % Cream0.07USD g
Triamcinolone 0.025% cream0.06USD g
Triamcinolone Acetonide 0.1% Ointment0.05USD gm
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2268927No2003-09-232017-07-02Canada
US5976573No1996-07-032016-07-03Us
US6143329No1996-07-032016-07-03Us
US7977045No1996-07-032016-07-03Us
US6395294No2000-01-132020-01-13Us
US8211880No2009-03-102029-03-10Us
US8128960No2009-12-172029-12-17Us
US8828440No2011-08-042031-08-04Us
US9555048No2011-08-042031-08-04Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)270 °CPhysProp
water solubility80 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.16HANSCH,C ET AL. (1995)
logS-3.69ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.847 mg/mLALOGPS
logP0.84ALOGPS
logP0.24ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)11.75ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area115.06 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity99.38 m3·mol-1ChemAxon
Polarizability39.79 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9823
Blood Brain Barrier+0.9528
Caco-2 permeable+0.7397
P-glycoprotein substrateSubstrate0.8204
P-glycoprotein inhibitor INon-inhibitor0.8759
P-glycoprotein inhibitor IINon-inhibitor0.9725
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8858
CYP450 2D6 substrateNon-substrate0.9006
CYP450 3A4 substrateSubstrate0.7049
CYP450 1A2 substrateNon-inhibitor0.9144
CYP450 2C9 inhibitorNon-inhibitor0.8939
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.911
CYP450 3A4 inhibitorNon-inhibitor0.9007
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.942
Ames testNon AMES toxic0.8858
CarcinogenicityNon-carcinogens0.9521
BiodegradationNot ready biodegradable0.9952
Rat acute toxicity2.3369 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9562
hERG inhibition (predictor II)Inhibitor0.6125
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (9.24 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-00di-2931000000-ee37afbf8c285181a340
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-006t-3970000000-70c8dcf068945a18ecdd
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 11-beta-hydroxysteroids / 16-alpha-hydroxysteroids / 17-hydroxysteroids / Halogenated steroids / 3-oxo delta-1,4-steroids / Delta-1,4-steroids / Tertiary alcohols / Alpha-hydroxy ketones
show 10 more
Substituents
Progestogin-skeleton / 21-hydroxysteroid / Pregnane-skeleton / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 9-halo-steroid / 17-hydroxysteroid / 16-hydroxysteroid / 11-hydroxysteroid
show 26 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 3-oxo Delta(4)-steroid, 20-oxo steroid, fluorinated steroid, 16alpha-hydroxy steroid, 21-hydroxy steroid, C21-steroid hormone (CHEBI:9667)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Nehme A, Lobenhofer EK, Stamer WD, Edelman JL: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. [PubMed:19744340]
  2. Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [PubMed:16507850]
  3. Shahin V, Ludwig Y, Schafer C, Nikova D, Oberleithner H: Glucocorticoids remodel nuclear envelope structure and permeability. J Cell Sci. 2005 Jul 1;118(Pt 13):2881-9. [PubMed:15976447]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Dort K, Padia S, Wispelwey B, Moore CC: Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report. AIDS Res Ther. 2009 Jun 8;6:10. doi: 10.1186/1742-6405-6-10. [PubMed:19505306]
  2. Hagan JB, Erickson D, Singh RJ: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. Pain Med. 2010 Jul;11(7):1132-5. doi: 10.1111/j.1526-4637.2010.00852.x. Epub 2010 Apr 29. [PubMed:20456080]
  3. Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Schaefer EC, Stewart AA, Durgam SS, Byron CR, Stewart MC: Effects of sodium hyaluronate and triamcinolone acetonide on glucosaminoglycan metabolism in equine articular chondrocytes treated with interleukin-1. Am J Vet Res. 2009 Dec;70(12):1494-501. doi: 10.2460/ajvr.70.12.1494. [PubMed:19951121]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Identical protein binding
Specific Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name
BCHE
Uniprot ID
P06276
Uniprot Name
Cholinesterase
Molecular Weight
68417.575 Da
References
  1. Ehrich M, Jortner BS, Gross WB: Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens. Toxicol Appl Pharmacol. 1988 Feb;92(2):214-23. [PubMed:3341034]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Binder
General Function
Steroid binding
Specific Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name
SERPINA6
Uniprot ID
P08185
Uniprot Name
Corticosteroid-binding globulin
Molecular Weight
45140.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Groyer A, Le Bouc Y, Joab I, Radanyi C, Renoir JM, Robel P, Baulieu EE: Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor. Eur J Biochem. 1985 Jun 3;149(2):445-51. [PubMed:3996417]
  4. Svec F, Harrison RW: Conditions affecting AtT-20 cell glucocorticoid uptake. Steroids. 1981 Feb;37(2):143-56. [PubMed:7222146]
  5. Eisen HJ: An antiserum to the rat liver glucocorticoid receptor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3893-7. [PubMed:7001446]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]

Drug created on June 13, 2005 07:24 / Updated on September 21, 2018 00:03