Identification

Name
Prednicarbate
Accession Number
DB01130  (APRD01197)
Type
Small Molecule
Groups
Approved, Investigational
Description

Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.

Structure
Thumb
Synonyms
Not Available
External IDs
LAS-189961 / LAS189961 / S 77 0777
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DermatopCream1 mg/gTopicalValeant Pharmaceuticals North America1993-10-292017-11-22Us
DermatopOintment1 mg/gTopicalValeant Pharmaceuticals North America2014-06-232017-11-04Us
Dermatop Emollient CreamCream0.1 %TopicalValeant Canada Lp Valeant Canada S.E.C.2001-03-21Not applicableCanada
Dermatop OintmentOintment0.1 %TopicalValeant Canada Lp Valeant Canada S.E.C.2001-03-21Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PrednicarbateCream1 mg/gTopicalPrasco, Laboratories2007-04-302017-11-14Us
PrednicarbateCream1 mg/gTopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2006-09-19Not applicableUs
PrednicarbateCream1 mg/gTopicalOceanside Pharmaceuticals1993-10-29Not applicableUs
PrednicarbateOintment1 mg/gTopicalFougera Pharmaceuticals Inc.2007-03-09Not applicableUs
International/Other Brands
Dermatop E Emollient
Categories
UNII
V901LV1K7D
CAS number
73771-04-7
Weight
Average: 488.577
Monoisotopic: 488.241018119
Chemical Formula
C27H36O8
InChI Key
FNPXMHRZILFCKX-KAJVQRHHSA-N
InChI
InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1
IUPAC Name
2-[(1S,2R,10S,11S,14R,15S,17S)-14-[(ethoxycarbonyl)oxy]-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate
SMILES
[H][C@@]12CC[C@](OC(=O)OCC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Pharmacology

Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Associated Conditions
Pharmacodynamics

Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids. These anti-inflammatory effects include inhibition of early processes such as edema, fibrin deposition, capillary dilatation, movement of phagocytes into the area, and phagocytic activities. Later processes, such as capillary production, collagen deposition, and keloid formation also are inhibited by corticosteroids.

Mechanism of action

In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Human
Absorption

Absorbed systemically across the stratum corneum.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Primarily in skin

Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Prednicarbate.Investigational
1,10-PhenanthrolineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with 1,10-Phenanthroline.Experimental
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Prednicarbate.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Acemetacin is combined with Prednicarbate.Approved, Experimental, Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Prednicarbate.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Prednicarbate.Approved
AlclofenacThe risk or severity of adverse effects can be increased when Alclofenac is combined with Prednicarbate.Approved, Withdrawn
AldesleukinPrednicarbate may decrease the antineoplastic activities of Aldesleukin.Approved
AlmasilateThe bioavailability of Prednicarbate can be decreased when combined with Almasilate.Approved, Experimental
AlminoprofenThe risk or severity of adverse effects can be increased when Alminoprofen is combined with Prednicarbate.Experimental
AloglutamolThe bioavailability of Prednicarbate can be decreased when combined with Aloglutamol.Approved
AloxiprinThe risk or severity of adverse effects can be increased when Aloxiprin is combined with Prednicarbate.Experimental
AluminiumThe bioavailability of Prednicarbate can be decreased when combined with Aluminium.Approved, Investigational
Aluminium acetoacetateThe bioavailability of Prednicarbate can be decreased when combined with Aluminium acetoacetate.Experimental
Aluminium glycinateThe bioavailability of Prednicarbate can be decreased when combined with Aluminium glycinate.Experimental
Aluminum hydroxideThe bioavailability of Prednicarbate can be decreased when combined with Aluminum hydroxide.Approved, Investigational
AmbenoniumThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ambenonium.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Prednicarbate.Approved
AmiodaroneThe metabolism of Prednicarbate can be decreased when combined with Amiodarone.Approved, Investigational
Amphotericin BPrednicarbate may increase the hypokalemic activities of Amphotericin B.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Andrographolide is combined with Prednicarbate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Prednicarbate.Investigational
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Anthrax immune globulin human.Approved
AntipyrineThe risk or severity of adverse effects can be increased when Antipyrine is combined with Prednicarbate.Approved, Investigational
AntrafenineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Antrafenine.Approved
ApalutamideThe serum concentration of Prednicarbate can be decreased when it is combined with Apalutamide.Approved, Investigational
ApocyninThe risk or severity of adverse effects can be increased when Apocynin is combined with Prednicarbate.Investigational
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Prednicarbate.Approved, Investigational
AprepitantThe serum concentration of Prednicarbate can be increased when it is combined with Aprepitant.Approved, Investigational
AtazanavirThe serum concentration of Prednicarbate can be increased when it is combined with Atazanavir.Approved, Investigational
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Prednicarbate.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Prednicarbate.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Prednicarbate.Approved
AzosemidePrednicarbate may increase the hypokalemic activities of Azosemide.Investigational
Bacillus calmette-guerin substrain connaught live antigenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Bacillus calmette-guerin substrain connaught live antigen.Approved, Investigational
Bacillus calmette-guerin substrain tice live antigenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Bacillus calmette-guerin substrain tice live antigen.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Balsalazide is combined with Prednicarbate.Approved, Investigational
BazedoxifeneThe serum concentration of Prednicarbate can be increased when it is combined with Bazedoxifene.Approved, Investigational
BCG vaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with BCG vaccine.Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Prednicarbate.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Bendazac is combined with Prednicarbate.Experimental
BendroflumethiazidePrednicarbate may increase the hypokalemic activities of Bendroflumethiazide.Approved
BenorilateThe risk or severity of adverse effects can be increased when Benorilate is combined with Prednicarbate.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Prednicarbate.Withdrawn
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Prednicarbate.Approved, Investigational
BenzthiazidePrednicarbate may increase the hypokalemic activities of Benzthiazide.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Benzydamine is combined with Prednicarbate.Approved
BevoniumThe risk or severity of adverse effects can be increased when Bevonium is combined with Prednicarbate.Experimental
Bismuth subcitrate potassiumThe bioavailability of Prednicarbate can be decreased when combined with Bismuth Subcitrate.Approved, Investigational
BoceprevirThe serum concentration of Prednicarbate can be increased when it is combined with Boceprevir.Approved, Withdrawn
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Prednicarbate.Approved
BucillamineThe risk or severity of adverse effects can be increased when Bucillamine is combined with Prednicarbate.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Budesonide is combined with Prednicarbate.Approved
BufexamacThe risk or severity of adverse effects can be increased when Bufexamac is combined with Prednicarbate.Approved, Experimental
BumadizoneThe risk or severity of adverse effects can be increased when Bumadizone is combined with Prednicarbate.Experimental
BumetanidePrednicarbate may increase the hypokalemic activities of Bumetanide.Approved
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Prednicarbate.Approved, Nutraceutical
Calcium CarbonateThe bioavailability of Prednicarbate can be decreased when combined with Calcium Carbonate.Approved, Investigational
Calcium silicateThe bioavailability of Prednicarbate can be decreased when combined with Calcium silicate.Experimental
Capromab pendetidePrednicarbate may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
CapsaicinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Capsaicin.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Prednicarbate.Approved, Investigational
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Prednicarbate.Experimental, Investigational
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Prednicarbate.Approved, Vet Approved, Withdrawn
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Prednicarbate.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Celecoxib is combined with Prednicarbate.Approved, Investigational
CeritinibPrednicarbate may increase the hyperglycemic activities of Ceritinib.Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Prednicarbate.Approved, Investigational, Vet Approved
ChlorothiazidePrednicarbate may increase the hypokalemic activities of Chlorothiazide.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Prednicarbate can be increased when it is combined with Chlorotrianisene.Investigational, Withdrawn
ChlorphenesinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorthalidonePrednicarbate may increase the hypokalemic activities of Chlorthalidone.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Prednicarbate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Prednicarbate.Approved
CimicoxibThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Cimicoxib.Investigational
CinoxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Cinoxacin.Approved, Investigational, Withdrawn
CiprofloxacinThe risk or severity of tendinopathy can be increased when Prednicarbate is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Cisplatin.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Prednicarbate.Approved
Clostridium tetani toxoid antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Prednicarbate is combined with Clostridium tetani toxoid antigen (formaldehyde inactivated).Approved
ClotrimazoleThe metabolism of Prednicarbate can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Prednicarbate can be increased when it is combined with Cobicistat.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Prednicarbate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Prednicarbate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Conjugated estrogensThe serum concentration of Prednicarbate can be increased when it is combined with Conjugated estrogens.Approved
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednicarbate.Approved
Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Prednicarbate is combined with Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated).Approved
CoumaphosThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Coumaphos.Vet Approved
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Prednicarbate.Approved, Investigational
CyclopenthiazidePrednicarbate may increase the hypokalemic activities of Cyclopenthiazide.Experimental
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Prednicarbate.Approved, Investigational, Vet Approved
DaidzeinThe serum concentration of Prednicarbate can be increased when it is combined with Daidzein.Experimental
DanazolPrednicarbate may increase the fluid retaining activities of Danazol.Approved
DarunavirThe serum concentration of Prednicarbate can be increased when it is combined with Darunavir.Approved
DecamethoniumThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Decamethonium.Approved
DeferasiroxThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Deferasirox.Approved, Investigational
DemecariumThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Demecarium.Approved
DersalazineThe risk or severity of adverse effects can be increased when Dersalazine is combined with Prednicarbate.Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Dexamethasone is combined with Prednicarbate.Approved, Investigational, Vet Approved
DexibuprofenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Dexketoprofen.Approved, Investigational
DichlorvosThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Dichlorvos.Vet Approved
DiclofenacThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Diclofenac.Approved, Vet Approved
DienestrolThe serum concentration of Prednicarbate can be increased when it is combined with Dienestrol.Approved, Investigational
DiethylstilbestrolThe serum concentration of Prednicarbate can be increased when it is combined with Diethylstilbestrol.Approved, Investigational
DifenpiramideThe risk or severity of adverse effects can be increased when Difenpiramide is combined with Prednicarbate.Experimental
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Prednicarbate.Approved, Investigational
DiltiazemThe metabolism of Prednicarbate can be decreased when combined with Diltiazem.Approved, Investigational
DipivefrinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Dipivefrin.Approved
DistigmineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Distigmine.Experimental
DonepezilThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Donepezil.Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Droxicam is combined with Prednicarbate.Withdrawn
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Prednicarbate.Investigational
E-6201The risk or severity of adverse effects can be increased when E-6201 is combined with Prednicarbate.Investigational
EchothiophateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Echothiophate.Approved
EdrophoniumThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Edrophonium.Approved
EnoxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Enoxacin.Approved, Investigational
EnzalutamideThe serum concentration of Prednicarbate can be decreased when it is combined with Enzalutamide.Approved
EpimestrolThe serum concentration of Prednicarbate can be increased when it is combined with Epimestrol.Experimental
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Prednicarbate.Approved
EpitizidePrednicarbate may increase the hypokalemic activities of Epitizide.Experimental
EquolThe serum concentration of Prednicarbate can be increased when it is combined with Equol.Investigational
EstradiolThe serum concentration of Prednicarbate can be increased when it is combined with Estradiol.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Prednicarbate can be increased when it is combined with Estradiol acetate.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Prednicarbate can be increased when it is combined with Estradiol cypionate.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Prednicarbate can be increased when it is combined with Estradiol valerate.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Prednicarbate can be increased when it is combined with Estriol.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe serum concentration of Prednicarbate can be increased when it is combined with Estrogens, esterified.Approved
EstroneThe serum concentration of Prednicarbate can be increased when it is combined with Estrone.Approved
Etacrynic acidPrednicarbate may increase the hypokalemic activities of Etacrynic acid.Approved, Investigational
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Prednicarbate.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Ethenzamide is combined with Prednicarbate.Experimental
Ethinyl EstradiolThe serum concentration of Prednicarbate can be increased when it is combined with Ethinyl Estradiol.Approved
EtodolacThe risk or severity of adverse effects can be increased when Etodolac is combined with Prednicarbate.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Prednicarbate.Approved, Investigational
EtoricoxibThe risk or severity of adverse effects can be increased when Etoricoxib is combined with Prednicarbate.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Prednicarbate.Investigational, Nutraceutical
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Prednicarbate.Approved
ExisulindThe risk or severity of adverse effects can be increased when Exisulind is combined with Prednicarbate.Investigational
FelbinacThe risk or severity of adverse effects can be increased when Felbinac is combined with Prednicarbate.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Prednicarbate.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Prednicarbate.Approved
FenthionThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Fenthion.Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Fentiazac is combined with Prednicarbate.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Feprazone is combined with Prednicarbate.Experimental
Ferulic acidThe risk or severity of adverse effects can be increased when Ferulic acid is combined with Prednicarbate.Experimental
FleroxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prednicarbate.Approved, Withdrawn
FlumequineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Flumequine.Withdrawn
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Prednicarbate.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Flunoxaprofen is combined with Prednicarbate.Experimental
FluoxymesteronePrednicarbate may increase the fluid retaining activities of Fluoxymesterone.Approved, Illicit
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Prednicarbate.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Prednicarbate.Approved
FluvoxamineThe metabolism of Prednicarbate can be decreased when combined with Fluvoxamine.Approved, Investigational
FosaprepitantThe serum concentration of Prednicarbate can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Prednicarbate can be decreased when it is combined with Fosphenytoin.Approved, Investigational
FurosemideThe risk or severity of hypokalemia can be increased when Prednicarbate is combined with Furosemide.Approved, Vet Approved
G17DTThe risk or severity of adverse effects can be increased when Prednicarbate is combined with G17DT.Investigational
GalantamineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Galantamine.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Gallamine Triethiodide.Approved
GarenoxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Garenoxacin.Investigational
GatifloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Gatifloxacin.Approved, Investigational
GemcitabineThe risk or severity of adverse effects can be increased when Gemcitabine is combined with Prednicarbate.Approved
GemifloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Prednicarbate can be increased when it is combined with Genistein.Investigational
GI-5005The risk or severity of adverse effects can be increased when Prednicarbate is combined with GI-5005.Investigational
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ginkgo biloba.Approved, Investigational, Nutraceutical
GinsengThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ginseng.Approved, Investigational, Nutraceutical
GLPG-0492Prednicarbate may increase the fluid retaining activities of GLPG-0492.Investigational
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Prednicarbate.Approved
GrepafloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Grepafloxacin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Guacetisal is combined with Prednicarbate.Experimental
Hemoglobin crosfumarilThe risk or severity of adverse effects can be increased when Hemoglobin crosfumaril is combined with Prednicarbate.Experimental
Hepatitis A VaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Hepatitis A Vaccine.Approved
Hepatitis B Vaccine (Recombinant)The risk or severity of adverse effects can be increased when Prednicarbate is combined with Hepatitis B Vaccine (Recombinant).Approved, Withdrawn
HexestrolThe serum concentration of Prednicarbate can be increased when it is combined with Hexestrol.Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Higenamine is combined with Prednicarbate.Investigational
Human rabies virus immune globulinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Human rabies virus immune globulin.Approved
Huperzine AThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Huperzine A.Approved, Investigational
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Prednicarbate.Approved, Investigational
HydrochlorothiazidePrednicarbate may increase the hypokalemic activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Prednicarbate.Approved, Illicit
HydrocortisoneThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Prednicarbate.Approved, Vet Approved
Hydrocortisone acetateThe risk or severity of adverse effects can be increased when Hydrocortisone acetate is combined with Prednicarbate.Approved, Vet Approved
Hydrocortisone butyrateThe risk or severity of adverse effects can be increased when Hydrocortisone butyrate is combined with Prednicarbate.Approved, Vet Approved
HydroflumethiazidePrednicarbate may increase the hypokalemic activities of Hydroflumethiazide.Approved, Investigational
HydrotalciteThe bioavailability of Prednicarbate can be decreased when combined with Hydrotalcite.Approved, Experimental, Investigational
IbuprofenThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Prednicarbate.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Prednicarbate.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Icosapent.Approved, Nutraceutical
IdelalisibThe serum concentration of Prednicarbate can be increased when it is combined with Idelalisib.Approved
Imidazole salicylateThe risk or severity of adverse effects can be increased when Imidazole salicylate is combined with Prednicarbate.Experimental
IndacaterolIndacaterol may increase the hypokalemic activities of Prednicarbate.Approved
IndapamidePrednicarbate may increase the hypokalemic activities of Indapamide.Approved
IndinavirThe serum concentration of Prednicarbate can be increased when it is combined with Indinavir.Approved
IndobufenThe risk or severity of adverse effects can be increased when Indobufen is combined with Prednicarbate.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Prednicarbate.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Prednicarbate.Withdrawn
INGN 201The risk or severity of adverse effects can be increased when Prednicarbate is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Prednicarbate is combined with INGN 225.Investigational
IpidacrineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ipidacrine.Experimental
IrinotecanThe risk or severity of adverse effects can be increased when Irinotecan is combined with Prednicarbate.Approved, Investigational
IsoflurophateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Isoflurophate.Approved, Investigational, Withdrawn
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Prednicarbate.Approved, Investigational
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Prednicarbate.Withdrawn
ItraconazoleThe serum concentration of Prednicarbate can be increased when it is combined with Itraconazole.Approved, Investigational
Japanese encephalitis virus strain sa 14-14-2 antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Prednicarbate is combined with Japanese encephalitis virus strain sa 14-14-2 antigen (formaldehyde inactivated).Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Prednicarbate.Experimental
KetoconazoleThe serum concentration of Prednicarbate can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Prednicarbate.Approved, Vet Approved
KetorolacThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Ketorolac.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Prednicarbate.Approved, Investigational
LevofloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Levofloxacin.Approved, Investigational
LevonorgestrelThe serum concentration of Prednicarbate can be increased when it is combined with Levonorgestrel.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Prednicarbate.Investigational
LomefloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Lomefloxacin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Lonazolac is combined with Prednicarbate.Experimental
LopinavirThe serum concentration of Prednicarbate can be increased when it is combined with Lopinavir.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Lornoxicam is combined with Prednicarbate.Approved, Investigational
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Prednicarbate.Approved, Investigational
LumacaftorThe serum concentration of Prednicarbate can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prednicarbate.Approved, Investigational
MagaldrateThe bioavailability of Prednicarbate can be decreased when combined with Magaldrate.Approved, Withdrawn
Magnesium carbonateThe bioavailability of Prednicarbate can be decreased when combined with Magnesium carbonate.Approved, Investigational
Magnesium hydroxideThe bioavailability of Prednicarbate can be decreased when combined with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe bioavailability of Prednicarbate can be decreased when combined with Magnesium oxide.Approved
Magnesium peroxideThe bioavailability of Prednicarbate can be decreased when combined with Magnesium peroxide.Experimental
Magnesium salicylateThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Prednicarbate.Approved
Magnesium silicateThe bioavailability of Prednicarbate can be decreased when combined with Magnesium silicate.Approved
Magnesium TrisilicateThe bioavailability of Prednicarbate can be decreased when combined with Magnesium Trisilicate.Approved
MalathionThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Malathion.Approved, Investigational
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Prednicarbate.Approved, Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Prednicarbate.Approved, Vet Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Prednicarbate.Approved
MefloquineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Mefloquine.Approved, Investigational
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Prednicarbate.Approved, Vet Approved
MemantineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Memantine.Approved, Investigational
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prednicarbate.Approved
MesterolonePrednicarbate may increase the fluid retaining activities of Mesterolone.Experimental
MestranolThe serum concentration of Prednicarbate can be increased when it is combined with Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Prednicarbate.Approved, Investigational, Withdrawn
MethallenestrilThe serum concentration of Prednicarbate can be increased when it is combined with Methallenestril.Experimental
Methanesulfonyl FluorideThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Methanesulfonyl Fluoride.Investigational
MethimazoleThe risk or severity of adverse effects can be increased when Methimazole is combined with Prednicarbate.Approved
MethyclothiazidePrednicarbate may increase the hypokalemic activities of Methyclothiazide.Approved
Methyl salicylateThe risk or severity of adverse effects can be increased when Methyl salicylate is combined with Prednicarbate.Approved, Vet Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with Prednicarbate.Approved, Vet Approved
MethyltestosteronePrednicarbate may increase the fluid retaining activities of Methyltestosterone.Approved
MetoclopramideThe therapeutic efficacy of Metoclopramide can be decreased when used in combination with Prednicarbate.Approved, Investigational
MetolazonePrednicarbate may increase the hypokalemic activities of Metolazone.Approved
MibefradilThe metabolism of Prednicarbate can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe metabolism of Prednicarbate can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MifepristoneThe therapeutic efficacy of Prednicarbate can be decreased when used in combination with Mifepristone.Approved, Investigational
MinaprineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Minaprine.Approved
MitotaneThe serum concentration of Prednicarbate can be decreased when it is combined with Mitotane.Approved
MivacuriumMivacurium may increase the adverse neuromuscular activities of Prednicarbate.Approved
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Prednicarbate.Investigational
MofebutazoneThe risk or severity of adverse effects can be increased when Mofebutazone is combined with Prednicarbate.Experimental
MorniflumateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Morniflumate.Approved
MoxestrolThe serum concentration of Prednicarbate can be increased when it is combined with Moxestrol.Experimental
MoxifloxacinThe risk or severity of tendinopathy can be increased when Prednicarbate is combined with Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Prednicarbate.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Prednicarbate.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Nabumetone is combined with Prednicarbate.Approved
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Prednicarbate.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Prednicarbate.Approved
Nalidixic AcidThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Nalidixic Acid.Approved, Investigational
NandrolonePrednicarbate may increase the fluid retaining activities of Nandrolone.Experimental, Investigational
Nandrolone decanoatePrednicarbate may increase the fluid retaining activities of Nandrolone decanoate.Approved, Illicit
NaproxenThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Naproxen.Approved, Vet Approved
NefazodoneThe serum concentration of Prednicarbate can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Prednicarbate can be increased when it is combined with Nelfinavir.Approved
NemonoxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Nemonoxacin.Investigational
NeostigmineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Neostigmine.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Nepafenac is combined with Prednicarbate.Approved, Investigational
NevirapineThe serum concentration of Prednicarbate can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Prednicarbate can be decreased when combined with Nicardipine.Approved, Investigational
NicorandilThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Nicorandil.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Nifenazone is combined with Prednicarbate.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Niflumic Acid is combined with Prednicarbate.Approved
NimesulideThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Prednicarbate.Approved, Investigational
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Prednicarbate.Investigational
NorfloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Norfloxacin.Approved
OfloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ofloxacin.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Prednicarbate.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Olsalazine is combined with Prednicarbate.Approved
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Prednicarbate.Vet Approved
OxandrolonePrednicarbate may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Prednicarbate.Approved
Oxolinic acidThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Oxolinic acid.Experimental
OxymetholonePrednicarbate may increase the fluid retaining activities of Oxymetholone.Approved, Illicit
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Prednicarbate.Approved, Withdrawn
PalmidrolThe risk or severity of adverse effects can be increased when Palmidrol is combined with Prednicarbate.Experimental, Nutraceutical
ParaoxonThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Paraoxon.Experimental
ParecoxibThe risk or severity of adverse effects can be increased when Parecoxib is combined with Prednicarbate.Approved
ParthenolideThe risk or severity of adverse effects can be increased when Parthenolide is combined with Prednicarbate.Approved, Investigational
PazufloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Pazufloxacin.Investigational
PefloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Pefloxacin.Approved
PentobarbitalThe serum concentration of Prednicarbate can be decreased when it is combined with Pentobarbital.Approved, Investigational, Vet Approved
PhenobarbitalThe metabolism of Prednicarbate can be increased when combined with Phenobarbital.Approved, Investigational
Phenyl aminosalicylateThe risk or severity of adverse effects can be increased when Phenyl aminosalicylate is combined with Prednicarbate.Approved
Phenylacetic acidThe therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednicarbate.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Prednicarbate.Approved, Vet Approved
Phenylbutyric acidThe therapeutic efficacy of Phenylbutyric acid can be decreased when used in combination with Prednicarbate.Approved, Investigational
PhenytoinThe serum concentration of Prednicarbate can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhysostigmineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Physostigmine.Approved, Investigational
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Prednicarbate.Approved, Investigational
Pipemidic acidThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Pipemidic acid.Experimental
PiretanidePrednicarbate may increase the hypokalemic activities of Piretanide.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Prednicarbate.Approved, Investigational
Piromidic acidThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Prednicarbate.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Pirprofen is combined with Prednicarbate.Experimental
Polyestradiol phosphateThe serum concentration of Prednicarbate can be increased when it is combined with Polyestradiol phosphate.Approved
PolythiazidePrednicarbate may increase the hypokalemic activities of Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Pomalidomide.Approved
PosaconazoleThe serum concentration of Prednicarbate can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PranoprofenThe risk or severity of adverse effects can be increased when Pranoprofen is combined with Prednicarbate.Experimental, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Prednisolone is combined with Prednicarbate.Approved, Vet Approved
PrimidoneThe serum concentration of Prednicarbate can be decreased when it is combined with Primidone.Approved, Vet Approved
ProglumetacinThe risk or severity of adverse effects can be increased when Proglumetacin is combined with Prednicarbate.Experimental
PromestrieneThe serum concentration of Prednicarbate can be increased when it is combined with Promestriene.Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Prednicarbate.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Propyphenazone is combined with Prednicarbate.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Proquazone is combined with Prednicarbate.Experimental
PrulifloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Prednicarbate.Investigational
PyrantelThe risk or severity of myopathy and weakness can be increased when Pyrantel is combined with Prednicarbate.Approved, Vet Approved
PyridostigmineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Pyridostigmine.Approved, Investigational
QuinestrolThe serum concentration of Prednicarbate can be increased when it is combined with Quinestrol.Approved
QuinethazonePrednicarbate may increase the hypokalemic activities of Quinethazone.Approved
Rabies virus inactivated antigen, AThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rabies virus inactivated antigen, A.Approved, Investigational
RapacuroniumRapacuronium may increase the adverse neuromuscular activities of Prednicarbate.Withdrawn
ResveratrolThe risk or severity of adverse effects can be increased when Resveratrol is combined with Prednicarbate.Approved, Experimental, Investigational
RifabutinThe serum concentration of Prednicarbate can be decreased when it is combined with Rifabutin.Approved, Investigational
RifampicinThe metabolism of Prednicarbate can be increased when combined with Rifampicin.Approved
RifapentineThe serum concentration of Prednicarbate can be decreased when it is combined with Rifapentine.Approved, Investigational
RindopepimutThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rindopepimut.Investigational
RivastigmineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rivastigmine.Approved, Investigational
RofecoxibThe risk or severity of adverse effects can be increased when Rofecoxib is combined with Prednicarbate.Approved, Investigational, Withdrawn
RosoxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rosoxacin.Approved, Investigational
Rotavirus VaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rotavirus Vaccine.Approved
Rubella virus vaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rubella virus vaccine.Approved, Investigational
RufloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Rufloxacin.Experimental
SalbutamolThe risk or severity of hypokalemia can be increased when Prednicarbate is combined with Salbutamol.Approved, Vet Approved
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Prednicarbate.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Prednicarbate.Approved, Investigational, Vet Approved
SalmeterolThe risk or severity of hypokalemia can be increased when Prednicarbate is combined with Salmeterol.Approved
Salmonella typhi ty2 vi polysaccharide antigenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Salmonella typhi ty2 vi polysaccharide antigen.Approved
Salmonella typhi Ty21a live antigenThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Salmonella typhi ty21a live antigen.Approved
SalsalateThe risk or severity of adverse effects can be increased when Salsalate is combined with Prednicarbate.Approved
SaquinavirThe serum concentration of Prednicarbate can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Prednicarbate.Approved
SecoisolariciresinolThe serum concentration of Prednicarbate can be increased when it is combined with Secoisolariciresinol.Investigational
SeliciclibThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Seliciclib.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Semapimod is combined with Prednicarbate.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Prednicarbate.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Serrapeptase is combined with Prednicarbate.Investigational
SitafloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Sitafloxacin.Experimental, Investigational
Sodium bicarbonateThe bioavailability of Prednicarbate can be decreased when combined with Sodium bicarbonate.Approved
SparfloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Sparfloxacin.Approved, Investigational
SRP 299The risk or severity of adverse effects can be increased when Prednicarbate is combined with SRP 299.Investigational
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Prednicarbate.Investigational
St. John's WortThe serum concentration of Prednicarbate can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StanolonePrednicarbate may increase the fluid retaining activities of Stanolone.Illicit, Investigational
StanozololPrednicarbate may increase the fluid retaining activities of Stanozolol.Approved, Vet Approved
StiripentolThe serum concentration of Prednicarbate can be increased when it is combined with Stiripentol.Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Sulfasalazine is combined with Prednicarbate.Approved
SulindacThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Sulindac.Approved, Investigational
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Prednicarbate.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Suxibuzone is combined with Prednicarbate.Experimental
Synthetic Conjugated Estrogens, AThe serum concentration of Prednicarbate can be increased when it is combined with Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Prednicarbate can be increased when it is combined with Synthetic Conjugated Estrogens, B.Approved
TacrineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Tacrine.Investigational, Withdrawn
TalniflumateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Talniflumate.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Tarenflurbil is combined with Prednicarbate.Investigational
TecemotideThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Tecemotide.Investigational
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Prednicarbate.Approved, Withdrawn
TelithromycinThe serum concentration of Prednicarbate can be increased when it is combined with Telithromycin.Approved
TemafloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Temafloxacin.Withdrawn
TenidapThe risk or severity of adverse effects can be increased when Tenidap is combined with Prednicarbate.Experimental
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Prednicarbate.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Prednicarbate.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Prednicarbate.Approved
TestosteronePrednicarbate may increase the fluid retaining activities of Testosterone.Approved, Investigational
Testosterone cypionateThe risk or severity of edema formation can be increased when Testosterone cypionate is combined with Prednicarbate.Approved
Testosterone enanthateThe risk or severity of edema formation can be increased when Testosterone enanthate is combined with Prednicarbate.Approved
Testosterone propionatePrednicarbate may increase the fluid retaining activities of Testosterone propionate.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe risk or severity of fluid retention can be increased when Testosterone undecanoate is combined with Prednicarbate.Approved, Investigational
TetrandrineThe risk or severity of adverse effects can be increased when Tetrandrine is combined with Prednicarbate.Experimental
TG4010The risk or severity of adverse effects can be increased when Prednicarbate is combined with TG4010.Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Prednicarbate.Approved
TiboloneThe serum concentration of Prednicarbate can be increased when it is combined with Tibolone.Approved, Investigational
TinoridineThe risk or severity of adverse effects can be increased when Tinoridine is combined with Prednicarbate.Investigational
Tolfenamic AcidThe risk or severity of gastrointestinal irritation can be increased when Prednicarbate is combined with Tolfenamic Acid.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Prednicarbate.Approved
TorasemidePrednicarbate may increase the hypokalemic activities of Torasemide.Approved
TriamcinoloneThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Triamcinolone.Approved, Vet Approved
TribenosideThe risk or severity of adverse effects can be increased when Tribenoside is combined with Prednicarbate.Experimental
TrichlorfonThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Trichlorfon.Vet Approved
TrichlormethiazidePrednicarbate may increase the hypokalemic activities of Trichlormethiazide.Approved, Vet Approved
TriptolideThe risk or severity of adverse effects can be increased when Triptolide is combined with Prednicarbate.Investigational
Trolamine salicylateThe risk or severity of adverse effects can be increased when Trolamine salicylate is combined with Prednicarbate.Approved
TromethamineThe bioavailability of Prednicarbate can be decreased when combined with Tromethamine.Approved
TrovafloxacinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Trovafloxacin.Approved, Investigational, Withdrawn
TubocurarineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Tubocurarine.Approved
Typhoid VaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Typhoid Vaccine.Approved
TyrothricinThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Tyrothricin.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Valdecoxib is combined with Prednicarbate.Approved, Investigational, Withdrawn
Varicella Zoster Vaccine (Live/Attenuated)The risk or severity of adverse effects can be increased when Prednicarbate is combined with Varicella Zoster Vaccine (Live/Attenuated).Approved
VecuroniumThe risk or severity of myopathy and weakness can be increased when Vecuronium is combined with Prednicarbate.Approved
VerapamilThe metabolism of Prednicarbate can be decreased when combined with Verapamil.Approved
VoriconazoleThe serum concentration of Prednicarbate can be increased when it is combined with Voriconazole.Approved, Investigational
WarfarinPrednicarbate may increase the anticoagulant activities of Warfarin.Approved
Yellow Fever VaccineThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Yellow Fever Vaccine.Approved, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Prednicarbate.Approved, Investigational
ZeranolThe serum concentration of Prednicarbate can be increased when it is combined with Zeranol.Vet Approved
ZidovudineThe risk or severity of adverse effects can be increased when Zidovudine is combined with Prednicarbate.Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Prednicarbate.Approved, Investigational, Withdrawn
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Prednicarbate.Withdrawn
Food Interactions
Not Available

References

General References
  1. Gupta AK, Chow M: A review of prednicarbate (Dermatop). Skin Therapy Lett. 2004 Dec-2005 Jan;9(10):5-6, 9. [PubMed:15657633]
External Links
PubChem Compound
6714002
PubChem Substance
46506799
ChemSpider
5145991
ChEBI
135791
ChEMBL
CHEMBL1200386
Therapeutic Targets Database
DAP001189
PharmGKB
PA164749394
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Prednicarbate
ATC Codes
D07AC18 — Prednicarbate
AHFS Codes
  • 84:06.00 — Anti-inflammatory Agents
FDA label
Download (130 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentPsoriasis1
2CompletedTreatmentDermatitis, Eczematous1
2CompletedTreatmentTinea Pedis1
2CompletedTreatmentCandidiasis infection1
Not AvailableCompletedTreatmentModerate to Severe Atopic Dermatitis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Dermik Labs
  • E. Fougera and Co.
  • Nycomed Inc.
  • Ortho Mcneil Janssen Pharmaceutical Inc.
  • Physicians Total Care Inc.
  • Prasco Labs
  • Sanofi-Aventis Inc.
Dosage forms
FormRouteStrength
OintmentTopical1 mg/g
CreamTopical0.1 %
OintmentTopical0.1 %
CreamTopical1 mg/g
Prices
Unit descriptionCostUnit
Prednicarbate 0.1% Ointment 60 gm Tube76.74USD tube
Dermatop 0.1% Cream 60 gm Tube75.2USD tube
Dermatop 0.1% Ointment 60 gm Tube70.06USD tube
Prednicarbate 0.1% Cream 60 gm Tube59.03USD tube
Prednicarbate 0.1% Ointment 15 gm Tube37.31USD tube
Prednicarbate 0.1% Cream 15 gm Tube24.0USD tube
Dermatop 0.1% cream1.76USD g
Prednicarbate 0.1% cream1.41USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
logP2.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00562 mg/mLALOGPS
logP3.08ALOGPS
logP3.83ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)14.83ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area116.2 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity127.8 m3·mol-1ChemAxon
Polarizability52.43 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9958
Blood Brain Barrier+0.984
Caco-2 permeable-0.571
P-glycoprotein substrateSubstrate0.7928
P-glycoprotein inhibitor IInhibitor0.8358
P-glycoprotein inhibitor IINon-inhibitor0.6129
Renal organic cation transporterNon-inhibitor0.7659
CYP450 2C9 substrateNon-substrate0.8753
CYP450 2D6 substrateNon-substrate0.895
CYP450 3A4 substrateSubstrate0.7638
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9054
CYP450 2D6 inhibitorNon-inhibitor0.9032
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.841
Ames testNon AMES toxic0.9186
CarcinogenicityNon-carcinogens0.9164
BiodegradationNot ready biodegradable0.9757
Rat acute toxicity2.4426 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8758
hERG inhibition (predictor II)Non-inhibitor0.5989
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00di-3971000000-7e24277333421d606578

Taxonomy

Description
This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Pregnane steroids
Direct Parent
Gluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Steroid esters / 20-oxosteroids / 3-oxo delta-1,4-steroids / 11-beta-hydroxysteroids / Delta-1,4-steroids / Alpha-acyloxy ketones / Carbonic acid diesters / Secondary alcohols / Cyclic ketones / Cyclic alcohols and derivatives
show 4 more
Substituents
Progestogin-skeleton / Steroid ester / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 11-hydroxysteroid / 11-beta-hydroxysteroid / Oxosteroid / Hydroxysteroid / Delta-1,4-steroid
show 17 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Boudinot FD, D'Ambrosio R, Jusko WJ: Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm. 1986 Oct;14(5):469-93. [PubMed:2879901]
  2. Ikonomidis I, Tzortzis S, Lekakis J, Paraskevaidis I, Andreadou I, Nikolaou M, Kaplanoglou T, Katsimbri P, Skarantavos G, Soucacos P, Kremastinos DT: Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis. Heart. 2009 Sep;95(18):1502-7. doi: 10.1136/hrt.2009.168971. Epub 2009 May 28. [PubMed:19482847]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.
  2. NCI/NIH [Link]
  3. University of Liverpool [Link]

Drug created on June 13, 2005 07:24 / Updated on August 14, 2018 04:32