Pharmaceutic Aids

Name
Pharmaceutic Aids
Accession Number
DBCAT001240
Description

Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.

Drugs
DrugDrug Description
ProbenecidA medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
TromethamineA proton acceptor used for the prevention and correction of metabolic acidosis associated with various clinical conditions, such as cardiac bypass surgery.
TragacanthAn extract from Tragacanth used in allergy testing.
PetrolatumFor use as an over the counter skin protectant [FDA Label]. Commonly used to treat diaper rash and chapped lips [FDA Label] .
PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
Magnesium Aluminum SilicateMagnesium aluminum silicate is used as an over the counter antacid for the self-treatment of heartburn, sour stomach, or acid indigestion [FDA Label].
Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
Poloxamer 188A medication used to clean wounds.
ChlorobutanolNo approved therapeutic indications on its own.
ThimerosalUsed as preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines [L1671, L1672, L1673].
TricaprylinTricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease.
AlmasilateAlmasilate is indicated for use as an antacid for the neutralization of excess stomach acid . It is subsequently also used for the symptomatic treatment of diseases where it is...
ImidureaImidurea is an antimicrobial preservative used in cosmetics. It acts as a formaldehyde releaser.
Microcrystalline celluloseA polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material,...
PropylparabenPropylparaben is used in allergenic testing.
BromothalonilBromothalonil is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
MethylparabenMethylparaben is used in allergenic testing.
Phenylethyl alcoholAn antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
Hydroxypropyl betadexHydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).
AspartameUsed as a diet supplement and sugar substitute.
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
D-glucoseA most commonly occurring isomer of glucose used as a carbohydrate supplementation in case of nutrient deprivation and metabolic disorders, such as hypoglycemia.
SucroseA nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet (beta vulgaris), and other plants and used extensively as...
MaltoseA dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
FructoseNot Available
LactoseAn additive and filler found in various products to maintain structure and consistency.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
Invert sugarInvert sugar presents a large variety of uses. It can be used therapeutically for parenteral hyperalimentation or to be used as an excipient with a known effect. Invert sugar is...
XylitolAn ingredient added to dental products to remove bacteria.
SaccharinSaccharin has been investigated for the treatment of Hypertension and Hyperglycemia.
SteviolbiosideSteviolbioside has been used in trials studying the treatment of HIV-1 Infection.
LactitolAn orally administered osmotic laxative used to treat chronic idiopathic constipation.
TriethylhexanoinNot Annotated
CinnamaldehydeCinnamaldehyde is approved by the FDA for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in...
Drugs & Drug Targets
DrugTargetType
ProbenecidSolute carrier family 22 member 8target
ProbenecidSolute carrier family 22 member 11target
ProbenecidSerum albumincarrier
ProbenecidSolute carrier family 22 member 2transporter
ProbenecidSolute carrier family 22 member 1transporter
ProbenecidCanalicular multispecific organic anion transporter 2transporter
ProbenecidMultidrug resistance-associated protein 4transporter
ProbenecidMultidrug resistance-associated protein 5transporter
ProbenecidMonocarboxylate transporter 2transporter
ProbenecidSolute carrier family 22 member 5transporter
ProbenecidMultidrug resistance-associated protein 6transporter
ProbenecidMultidrug resistance-associated protein 1transporter
ProbenecidSolute carrier organic anion transporter family member 1A2transporter
ProbenecidMonocarboxylate transporter 1transporter
ProbenecidSodium/bile acid cotransportertransporter
ProbenecidSolute carrier family 22 member 6transporter
ProbenecidSolute carrier family 22 member 10transporter
ProbenecidSolute carrier family 22 member 8transporter
ProbenecidCanalicular multispecific organic anion transporter 1transporter
ProbenecidATP-binding cassette sub-family C member 11transporter
ProbenecidSolute carrier family 22 member 11transporter
ProbenecidSolute carrier organic anion transporter family member 1C1transporter
ProbenecidSolute carrier family 22 member 7transporter
ProbenecidSolute carrier family 22 member 6target
ProbenecidPannexin-1target
ProbenecidCytochrome P450 2C8enzyme
ProbenecidCytochrome P450 3A4enzyme
ProbenecidSolute carrier family 22 member 12transporter
ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
ProbenecidTaste receptor type 2 member 16target
ProbenecidUDP-glucuronosyltransferase 1-1enzyme
ProbenecidCytochrome P450 2C9enzyme
Propylene glycolB12-independent glycerol dehydratasetarget
TromethamineAmyloid beta A4 proteintarget
ChlorobutanolPotassium voltage-gated channel subfamily H member 2target
ThimerosalSerum albumincarrier
ThimerosalInositol 1,4,5-trisphosphate receptor type 1transporter
ThimerosalMethionine synthasetarget
ThimerosalCystine/glutamate transportertarget
ThimerosalSodium/potassium-transporting ATPase subunit gammatarget
ThimerosalGlutathione reductase, mitochondrialenzyme
ThimerosalGlutathione peroxidase 1enzyme
ThimerosalSuperoxide dismutase [Mn], mitochondrialenzyme
Phenylethyl alcoholParathion hydrolasetarget
AspartameTaste receptor type 1 member 2target
AspartameTransient receptor potential cation channel subfamily V member 1target
AspartameSolute carrier family 22 member 6transporter
AspartameSolute carrier family 22 member 8transporter
AspartameSolute carrier family 22 member 11transporter
AspartameTaste receptor type 1 member 3target
MannitolMannitol dehydrogenaseenzyme
D-glucoseHexokinase-1enzyme
D-glucoseGlucokinaseenzyme
D-glucoseSolute carrier family 2, facilitated glucose transporter member 1transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 2transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 3transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 4transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 5transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 6transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 7transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 8transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 9transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 10transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 11transporter
D-glucoseSolute carrier family 2, facilitated glucose transporter member 12transporter
D-glucoseSodium/glucose cotransporter 1transporter
D-glucoseSodium/glucose cotransporter 2transporter
D-glucoseSerum albumincarrier
SucroseBeta-lactamasetarget
SucroseLysozyme Ctarget
SucroseActin, alpha skeletal muscletarget
SucroseBeta-glucosidasetarget
SucroseAmylosucrasetarget
SucroseBeta-lactamasetarget
SucroseBeta-lactamase CTX-Mtarget
SucroseHeme oxygenasetarget
SucroseCopper transport protein ATOX1target
SucrosetRNA-splicing ligase RtcB homologtarget
SucroseOrange carotenoid-binding proteintarget
SucroseSucrose porintarget
SucroseLevansucrasetarget
SucroseTaste receptor type 1 member 2target
MaltoseCyclomaltodextrin glucanotransferasetarget
MaltoseAlpha-amylase 2Btarget
MaltoseBeta-amylasetarget
MaltoseMaltogenic alpha-amylasetarget
MaltoseMaltodextrin phosphorylasetarget
MaltoseMaltose-binding periplasmic proteintarget
MaltoseAlpha-glucosidasetarget
MaltoseMaltose binding proteintarget
MaltoseMalto-oligosyltrehalose trehalohydrolasetarget
FructoseMaltoporintarget
LactoseBeta-galactosidasetarget
LactoseGlycosyltransferase 6 domain-containing protein 1target
LactoseGlycolipid transfer proteintarget
LactoseHydrolasetarget
LactoseEndo-1,4-beta-xylanase Atarget
LactoseGalectin-3target
LactoseSialidasetarget
LactoseBeta-galactosidasetarget
Polyethylene glycolP-glycoprotein 1transporter
Invert sugarSolute carrier family 2, facilitated glucose transporter member 2transporter
Invert sugarSolute carrier family 2, facilitated glucose transporter member 5transporter
Invert sugarGlucokinaseenzyme
Invert sugar6-phosphofructokinaseenzyme
XylitolXylose isomerasetarget
XylitolXylose isomerasetarget
XylitolXylose isomerasetarget
XylitolXylose isomerasetarget
XylitolHyaluronate lyasetarget
SaccharinCarbonic anhydrase 3target