Drugs for Acid Related Disorders

Name
Drugs for Acid Related Disorders
Accession Number
DBCAT002221
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
PantoprazoleA proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.
OmeprazoleA proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.
SucralfateA gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.
LansoprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
NizatidineAn H2 receptor antagonist used to treat GERD and a variety of ulcers.
PirenzepineAn antimuscarinic agent used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
EsomeprazoleA proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.
RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
TinidazoleA nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.
FamotidineA histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.
MisoprostolA prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers and to terminate pregnancies.
RabeprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
CarbenoxoloneA drug used to symptomatically treat lip sores and mouth ulcers.
DexlansoprazoleA proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD).
Aluminum hydroxideAn antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
Calcium carbonateAn ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
Roxatidine acetateFor the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also...
MagaldrateAn antacid used to treat various conditions in the GI tract, such as esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux.
GefarnateGefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease.
LafutidineLafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD).
Bismuth subnitrateA medication used as an antacid.
Magnesium silicateMagnesium silicate is used to absorb moisture, prevent caking, and to improve the feel of a product. In the pharmaceutical companies, it is used as a dietary supplement, as part...
Methylmethionine chlorideMethylmethionine chloride may be useful in helping the healing of gastric ulcers. In Japan, it is used as an over the counter product for gastrointestinal health support. It is also...
Aluminium acetoacetateAluminium acetoacetate is an aluminum containing antacid.
SulglicotideNot Annotated
HydrotalciteAn antacid indicated in the treatment of heartburn and excess gastric acid.
TroxipideNot Annotated
ProglumideNot Annotated
Magnesium peroxideNot Annotated
Alginic acidIndicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress .
ZolimidineNot Annotated
AlmasilateAlmasilate is indicated for use as an antacid for the neutralization of excess stomach acid . It is subsequently also used for the symptomatic treatment of diseases where it is...
Aluminium glycinateA medication indicated to treat heartburn, indigestion, acid reflux, ulcers, and gas.
AcetoxoloneNot Annotated
AloglutamolAloglutamol is an antacid salt of aluminium, gluconic acid, and tris. Proprietary names include Altris, Pyreses, Tasto and Sabro.
NiperotidineNot Annotated
DexrabeprazoleA proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers.
EnprostilNot Annotated
Calcium silicateNot Annotated
TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.
AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
Magnesium hydroxideAn inorganic compound used as a laxative and antacid.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Aluminium phosphateNot Available
RebamipideA gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa.
VonoprazanA potassium-competitive acid blocker used in the treatment of acid-related disorders and as an adjunct to Helicobacter pylori eradication.
Bismuth subcitrate potassiumA colloid used for the treatment of peptic ulcer and gastro-esophageal reflux disease (GERD).
RifabutinAn antibiotic used to treat mycobacterium avium complex disease in patients with HIV.
TegoprazanTegoprazan (also known as CJ-12420) is a novel therapeutic developed by CJ Healthcare Corp for treating acid-related gastrointestinal diseases.[A234215, A234220] This drug is a potent and high-selective potassium-competitive acid blocker...
TeprenoneA medication indicated in the treatment of acute gastroenteritis, exacerbations of gastric inflammation, and gastric ulcers.
Drugs & Drug Targets
DrugTargetType
PantoprazolePotassium-transporting ATPase alpha chain 1target
PantoprazoleCytochrome P450 2C19enzyme
PantoprazoleCytochrome P450 3A4enzyme
PantoprazoleP-glycoprotein 1transporter
PantoprazoleATP-binding cassette sub-family G member 2transporter
PantoprazoleSolute carrier family 22 member 8transporter
PantoprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
OmeprazolePotassium-transporting ATPase alpha chain 1target
OmeprazoleCytochrome P450 2C19enzyme
OmeprazoleCytochrome P450 3A4enzyme
OmeprazoleCytochrome P450 2C9enzyme
OmeprazoleCytochrome P450 1A2enzyme
OmeprazoleCanalicular multispecific organic anion transporter 2transporter
OmeprazoleP-glycoprotein 1transporter
OmeprazoleATP-binding cassette sub-family G member 2transporter
OmeprazoleCytochrome P450 1A1enzyme
OmeprazoleCytochrome P450 1B1enzyme
OmeprazoleCytochrome P450 2C18enzyme
OmeprazoleCytochrome P450 2C8enzyme
OmeprazoleCytochrome P450 2D6enzyme
OmeprazoleAryl hydrocarbon receptortarget
SucralfateFibrinogentarget
SucralfatePepsin A-5target
SucralfatePro-epidermal growth factortarget
SucralfateFibroblast growth factor 2target
LansoprazolePotassium-transporting ATPase alpha chain 1target
LansoprazoleCytochrome P450 2C19enzyme
LansoprazoleCytochrome P450 2C9enzyme
LansoprazoleCytochrome P450 3A4enzyme
LansoprazoleP-glycoprotein 1transporter
LansoprazoleATP-binding cassette sub-family G member 2transporter
LansoprazoleCytochrome P450 1A1enzyme
LansoprazoleCytochrome P450 1B1enzyme
LansoprazoleCytochrome P450 2C18enzyme
LansoprazoleCytochrome P450 2C8enzyme
LansoprazoleCytochrome P450 2D6enzyme
LansoprazoleMicrotubule-associated protein tautarget
LansoprazoleSolute carrier family 22 member 8transporter
LansoprazoleSolute carrier family 22 member 1transporter
LansoprazoleSolute carrier family 22 member 2transporter
LansoprazoleSolute carrier family 22 member 3transporter
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
CimetidineSerum albumincarrier
NizatidineHistamine H2 receptortarget
NizatidineP-glycoprotein 1transporter
NizatidineCholinesteraseenzyme
PirenzepineMuscarinic acetylcholine receptor M1target
EsomeprazolePotassium-transporting ATPase alpha chain 1target
EsomeprazoleCytochrome P450 2C19enzyme
EsomeprazoleCytochrome P450 3A4enzyme
EsomeprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
EsomeprazoleP-glycoprotein 1transporter
EsomeprazoleSolute carrier family 22 member 8transporter
RanitidineHistamine H2 receptortarget
RanitidineCytochrome P450 1A2enzyme
RanitidineCytochrome P450 2D6enzyme
RanitidineSolute carrier family 22 member 1transporter
RanitidineP-glycoprotein 1transporter
RanitidineSolute carrier family 22 member 8transporter
RanitidineCytochrome P450 3A4enzyme
RanitidineAcetylcholinesterasetarget
RanitidineSolute carrier family 22 member 2transporter
RanitidineAcetylcholinesteraseenzyme
TinidazoleCytochrome P450 3A4enzyme
TinidazoleDNAtarget
TinidazoleBile salt export pumptransporter
FamotidineHistamine H2 receptortarget
FamotidineSolute carrier family 22 member 2transporter
FamotidineSolute carrier family 22 member 8transporter
FamotidineMultidrug and toxin extrusion protein 1transporter
FamotidineCytochrome P450 1A2enzyme
FamotidineSolute carrier family 22 member 6transporter
MisoprostolProstaglandin E2 receptor EP2 subtypetarget
MisoprostolProstaglandin E2 receptor EP3 subtypetarget
MisoprostolProstaglandin E2 receptor EP4 subtypetarget
MisoprostolProstaglandin E2 receptor EP1 subtypetarget
RabeprazolePotassium-transporting ATPase alpha chain 1target
RabeprazoleCytochrome P450 3A4enzyme
RabeprazoleCytochrome P450 2C19enzyme
RabeprazoleATP-binding cassette sub-family G member 2transporter
RabeprazoleCytochrome P450 1A1enzyme
RabeprazoleCytochrome P450 1A2enzyme
RabeprazoleCytochrome P450 2C9enzyme
RabeprazoleCytochrome P450 2D6enzyme
RabeprazoleCytochrome P450 2C8enzyme
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
Carbenoxolone3-alpha-(or 20-beta)-hydroxysteroid dehydrogenasetarget
CarbenoxoloneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DexlansoprazolePotassium-transporting ATPase alpha chain 1target
DexlansoprazoleCytochrome P450 2C19enzyme
DexlansoprazoleCytochrome P450 3A4enzyme
DexlansoprazolePotassium-transporting ATPase subunit betatarget
DexlansoprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
Roxatidine acetateHistamine H2 receptortarget
NiperotidineHistamine H2 receptortarget
DexrabeprazoleCytochrome P450 2C19enzyme
Tetracycline16S ribosomal RNAtarget
TetracyclineMajor prion proteintarget
TetracyclineSerum albumincarrier
TetracyclineCytochrome P450 3A4enzyme
TetracyclineSolute carrier family 22 member 6transporter
TetracyclineSolute carrier family 22 member 8transporter
TetracyclineSolute carrier family 22 member 11transporter
TetracyclineSolute carrier family 22 member 7transporter
Tetracycline30S ribosomal protein S3target
Tetracycline30S ribosomal protein S8target
Tetracycline30S ribosomal protein S19target
Tetracycline30S ribosomal protein S14target
Tetracycline30S ribosomal protein S7target
TetracyclineMultidrug translocase MdfAtarget
TetracyclineProtein-arginine deiminase type-4target
TetracyclineSolute carrier organic anion transporter family member 2B1transporter
MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
MetronidazoleCytochrome P450 2C9enzyme
MetronidazoleCytochrome P450 3A4enzyme
MetronidazoleCytochrome P450 2C8enzyme
MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
MetronidazoleAnaerobic bacterial DNAtarget
MetronidazoleProtozoal DNAtarget
MetronidazoleP-glycoprotein 1transporter
MetronidazoleCytochrome P450 2A6enzyme
MetronidazoleCytochrome P450 3A5enzyme
MetronidazoleCytochrome P450 3A7enzyme
AmoxicillinSolute carrier family 15 member 1transporter
AmoxicillinSolute carrier family 15 member 2transporter
AmoxicillinSolute carrier family 22 member 6transporter
AmoxicillinCytochrome P450 2C8enzyme
AmoxicillinSerum albumincarrier
AmoxicillinBeta-lactamase 2enzyme
AmoxicillinPenicillin binding proteintarget
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
Aluminium phosphateSerotransferrintarget
Aluminium phosphateSodium/potassium-transporting ATPase subunit alpha-1target
Aluminium phosphateSerum albumincarrier
Aluminium phosphateKallikrein-1target
Aluminium phosphateAmyloid beta A4 proteintarget
VonoprazanHydrogen potassium ATPasetarget
VonoprazanCytochrome P450 3A4enzyme
VonoprazanCytochrome P450 3A5enzyme
VonoprazanCytochrome P450 2B6enzyme
VonoprazanCytochrome P450 2C19enzyme
VonoprazanCytochrome P450 2C9enzyme
VonoprazanCytochrome P450 2D6enzyme
VonoprazanP-glycoprotein 1transporter
VonoprazanSerum albumincarrier
VonoprazanAlpha-1-acid glycoprotein 1carrier
Bismuth subcitrate potassiumATP-dependent Clp protease ATP-binding subunit ClpXtarget
RifabutinDNA-directed RNA polymerase subunit alphatarget
RifabutinHeat shock protein HSP 90-alphatarget
RifabutinEndoplasmintarget
RifabutinCytochrome P450 3A4enzyme
RifabutinDNA-directed RNA polymerase subunit betatarget
RifabutinDNA-directed RNA polymerase subunit beta'target
RifabutinCytochrome P450 2C19enzyme
RifabutinCytochrome P450 2B6enzyme
RifabutinCytochrome P450 2C8enzyme
RifabutinCytochrome P450 2C9enzyme
RifabutinP-glycoprotein 1transporter
TegoprazanSodium/Potassium Transporting ATPasetarget