Magnesium oxide

Identification

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Name
Magnesium oxide
Accession Number
DB01377
Type
Small Molecule
Groups
Approved
Description

Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

Structure
Thumb
Synonyms
  • Magnesia
External IDs
E-530 / INS NO.530 / INS-530
Active Moieties
NameKindUNIICASInChI Key
Magnesium cationionicT6V3LHY83822537-22-0JLVVSXFLKOJNIY-UHFFFAOYSA-N
MagnesiumunknownI38ZP9992A7439-95-4RSHAOIXHUHAZPM-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium OxideTablet400 mg/1OralAphena Pharma Solutions - Tennessee, LLC2016-02-01Not applicableUs
Magnesium OxideTablet400 mg/1OralVirtus Pharmaceuticals2014-04-092016-10-04Us
Magnesium OxideTablet400 mg/1OralSafecor Health, LLC2014-09-30Not applicableUs
Magnesium OxideTablet420 mg/1OralRichmond Pharmaceuticals, Inc.2016-02-01Not applicableUs
Magnesium OxideTablet400 mg/1OralMethod Pharmaceuticals2018-07-25Not applicableUs
Magnesium OxideTablet400 mg/1OralA&Z Pharmaceutical, Inc.2003-12-032015-05-05Us
Magnesium OxideTablet253 mg/1OralQualitest2003-10-062018-10-24Us
Magnesium OxideTablet400 mg/1OralMarlex Pharmaceuticals Inc2019-02-01Not applicableUs
Magnesium OxideTablet400 mg/1OralH. J. Harkins Company Inc.2017-06-16Not applicableUs
Magnesium OxideTablet400 mg/1OralVirtus Pharmaceuticals2015-09-082018-09-17Us
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Anaplex TabMagnesium oxide (50 mg) + Ascorbic acid (40 mg) + Calcium (160 mg) + Iodine (.05 mg) + Nicotinamide (30 mg) + Calcium pantothenate (15 mg) + Phosphorus (75.33 mg) + Potassium chloride (20 mg) + Pyridoxine hydrochloride (40 mg) + Vitamin A palmitate (2000 unit) + Vitamin D (133.33 unit)TabletOralAnabolic Laboratories Inc.1975-12-311996-10-02Canada
Aspirin Plus Stomach Guard Ext.stgth.capletMagnesium oxide (96.9 mg) + Acetylsalicylic acid (500 mg) + Calcium carbonate (246.2 mg) + Magnesium carbonate (52.3 mg)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada
Aspirin Plus Stomach Guard Extra StrengthMagnesium oxide (96.95 mg) + Acetylsalicylic acid (500 mg) + Calcium carbonate (246.22 mg) + Magnesium carbonate (52.32 mg)TabletOralBayer Inc Consumer Care1995-12-311998-09-28Canada
Aspirin Plus Stomach Guard TabMagnesium oxide (63 mg) + Acetylsalicylic acid (325 mg) + Calcium carbonate (160 mg) + Magnesium carbonate (34 mg)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada
Aspirin With Stomach GuardMagnesium oxide (63 mg) + Acetylsalicylic acid (325 mg) + Calcium carbonate (160 mg) + Magnesium carbonate (34 mg)TabletOralBayer Inc Consumer Care1997-10-012012-07-12Canada
Aspirin With Stomach Guard Extra Strength - TabMagnesium oxide (96.9 mg) + Acetylsalicylic acid (500 mg) + Calcium carbonate (246.2 mg) + Magnesium carbonate (52.3 mg)TabletOralBayer Inc Consumer Care1997-07-072012-07-12Canada
B6 Plus TabMagnesium oxide (50 mg) + Niacin (20 mg) + Potassium citrate (50 mg) + Pyridoxine hydrochloride (50 mg) + Riboflavin (2.4 mg) + Thiamine (10 mg)TabletOralVita Health Products Inc1979-12-312002-08-01Canada
C-apnto-B6 Vitamins W Magnesium TabMagnesium oxide (60 mg) + Ascorbic acid (240 mg) + Calcium pantothenate (500 mg) + Pyridoxine (250 mg)TabletOralMetagenics, Inc.1989-12-311996-10-02Canada
Calcemin SilverMagnesium oxide (40 mg/1) + Boron (2.6 mg/1) + Zinc oxide (7.5 mg/1)Tablet, film coatedOralBayer Healthcare Llc.2016-04-01Not applicableUs
Calcium - Magnesium - Zinc TabMagnesium oxide (133 mg) + Calcium carbonate (333 mg) + Zinc gluconate (8 mg)TabletOralNutristar Health Products (1987) Inc.1992-12-311996-09-09Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active FEMagnesium oxide (30 mg/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + DL-alpha tocopheryl acetate (40 [iU]/1) + Folic acid (1250 ug/1) + Iron (75 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUs
BacminMagnesium oxide (50 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Manganese gluconate (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)Tablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Bal-Care DHAMagnesium oxide (25 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralPru Gen Pharmaceuticals2012-05-01Not applicableUs
Bal-Care DHA EssentialMagnesium oxide (25 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iodine (.223 mg/1) + Iron sucrose (1.35 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralPru Gen Pharmaceuticals2012-05-01Not applicableUs
BumP DHAMagnesium oxide (125 mg/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Flavin mononucleotide (2 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1)CapsuleOralCenturion Labs2017-03-242017-04-17Us
Cavan AlphaMagnesium oxide (25 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iodine (220 ug/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30Us
Cavan Folate DHAMagnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-06-042012-03-31Us
Cavan Folate DHAMagnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-06-042012-03-31Us
Cavan Folate OBMagnesium oxide (25 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (65 mg/1) + Folic acid (1 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1)TabletOralSeton Pharmaceuticals2010-08-232012-05-31Us
Cavan-EC SOD DHAMagnesium oxide (25 mg/1) + Ascorbic acid (130 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (410 [iU]/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (440 mg/1) + Pyridoxine hydrochloride (28 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (30 mg/1) + Zinc oxide (26 mg/1)KitOralPhysicians Total Care, Inc.2010-08-242013-01-15Us
International/Other Brands
Magmitt
Categories
UNII
3A3U0GI71G
CAS number
1309-48-4
Weight
Average: 40.304
Monoisotopic: 39.97995652
Chemical Formula
MgO
InChI Key
AXZKOIWUVFPNLO-UHFFFAOYSA-N
InChI
InChI=1S/Mg.O/q+2;-2
IUPAC Name
magnesium(2+) oxidandiide
SMILES
[O--].[Mg++]

Pharmacology

Indication

Indicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach.

Associated Conditions
Associated Therapies
Pharmacodynamics
Not Available
Mechanism of action

The term "Milk of Magnesia" was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation.

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

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Additional Data Available
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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1alpha-Hydroxyvitamin D5The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Magnesium oxide.
2,5-Dimethoxy-4-ethylthioamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Magnesium oxide.
3-Aza-2,3-Dihydrogeranyl DiphosphateMagnesium oxide can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamineThe serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Magnesium oxide.
AbafunginMagnesium oxide can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcepromazineMagnesium oxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AceprometazineMagnesium oxide can cause a decrease in the absorption of Aceprometazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetaminophenMagnesium oxide can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
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Food Interactions
Not Available

References

Synthesis Reference

Jajnya D. Panda, Santosh K. Mahapatra, "Process for the production of magnesium oxide from brine or bittern." U.S. Patent US4370422, issued June, 1921.

US4370422
General References
  1. Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R: Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. 2000 Jul;18(7):919-26. [PubMed:10930190]
  2. Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK, Molloy MD, Dwyer JH, Shah PK, Kaul S: Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol. 1999 Jul 15;84(2):152-6. [PubMed:10426331]
External Links
Human Metabolome Database
HMDB0015458
KEGG Drug
D01167
KEGG Compound
C12567
PubChem Compound
14792
PubChem Substance
46504815
ChemSpider
5254017
ChEBI
31794
ChEMBL
CHEMBL1200572
PharmGKB
PA450298
Drugs.com
Drugs.com Drug Page
Wikipedia
Magnesia
ATC Codes
A02AA02 — Magnesium oxideA12CC10 — Magnesium oxideA06AD02 — Magnesium oxide
AHFS Codes
  • 88:29.00* — Minerals

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentConcussion Post Syndrome1
1, 2CompletedTreatmentNeed for Bowel Preparation1
1, 2Not Yet RecruitingScreeningBowel Preparation for Pediatric Colonoscopy / Bowel preparation therapy1
2CompletedScreeningHealthy Volunteers1
2CompletedSupportive CareBreast Cancer / Cancer Survivors / Hot Flushes1
2CompletedSupportive CareBreast Cancer / Cancer Survivors / Hot Flushes / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentDiabetic Polyneuropathy / Oxidative Stress1
2CompletedTreatmentImpaired Glucose Tolerance2
2CompletedTreatmentMetabolic Syndromes4
2CompletedTreatmentPseudoxanthoma Elasticum1
2CompletedTreatmentType 2 Diabetes Mellitus2
2Not Yet RecruitingTreatmentMetabolic Syndromes1
2RecruitingPreventionHigh Risk Pregnancies1
2RecruitingTreatmentPre-Diabetic1
2RecruitingTreatmentMixed hypercholesterolemia1
2TerminatedTreatmentType 2 Diabetes Mellitus1
2, 3CompletedTreatmentType 2 Diabetes Mellitus1
2, 3Not Yet RecruitingTreatmentDyslipidemias / Overweight or Obesity1
2, 3RecruitingTreatmentMetabolic Syndromes1
3CompletedNot AvailableBowel Preparation for Colonoscopy1
3CompletedNot AvailableSubjects Undergoing a Complete Exploratory Diagnostic Colonoscopy for the First Time1
3CompletedOtherBowel preparation therapy1
3CompletedTreatmentAntioxidant Enzyme System / Type 2 Diabetes Mellitus1
3CompletedTreatmentBowel preparation therapy2
3RecruitingTreatmentHeart Failure / Magnesium Deficiency1
3RecruitingTreatmentICSI1
3Unknown StatusTreatmentBowel Preparation Before Colonoscopy1
4CompletedNot AvailableBowel preparation therapy1
4CompletedDiagnosticColonoscopy1
4CompletedDiagnosticHemodynamics / Hyponatremia1
4CompletedSupportive CareMalignant Neoplasm of Colon1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentCathartic Colon1
4CompletedTreatmentColonoscopy1
4CompletedTreatmentFunctional Constipation1
4RecruitingDiagnosticBowel Preparation Solutions1
4Unknown StatusDiagnosticBowel preparation therapy / Colonoscopy1
4Unknown StatusTreatmentBowel Preparation Solutions / Endoscopy1
Not AvailableCompletedHealth Services ResearchColorectal Liver Metastases1
Not AvailableCompletedTreatmentDyspepsia / Gastrointestinal Diseases1
Not AvailableNot Yet RecruitingPreventionColostomy Stoma / Hirschprung's Disease / Ileostomy - Stoma / Inflammatory Bowel Diseases (IBD) / Intestinal Obstruction / Jejunostomy Stoma / Meconium Ileus / NEC1
Not AvailableRecruitingNot AvailableBowel preparation therapy1
Not AvailableRecruitingDiagnosticColonoscopy1
Not AvailableRecruitingTreatmentInadequate Preparation for Colonoscopy; Personalized Colonoscopy Preparation1
Not AvailableWithdrawnScreeningPatients Undergoing Screening or Surveillance Colonoscopy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Bayer Healthcare
  • Blaine Pharmaceuticals
  • Gallipot
  • Major Pharmaceuticals
  • Manne Co.
  • Mckesson Corp.
  • Particle Dynamics Co.
  • Qualitest
  • Rising Pharmaceuticals
  • Rugby Laboratories
  • Walgreen Co.
Dosage forms
FormRouteStrength
KitOral
KitNot applicable
TabletOral
Tablet, coatedOral
TabletOral253 mg/1
TabletOral400 mg/1
TabletOral420 mg/1
TabletOral
Powder1 kg/1kg
CapsuleOral
Powder, for solutionOral
Capsule, gelatin coatedOral
Powder, meteredOral
PillOral
LiquidOral
WaferOral
Capsule, liquid filledOral
SolutionIrrigation
LiquidIrrigation
Tablet, film coatedOral
Tablet, chewableOral
Prices
Unit descriptionCostUnit
Phillips 500 mg caplet0.18USD caplet
Magnesium oxide 400 mg tablet0.13USD tablet
Magnesium oxide 420 mg tablet0.11USD tablet
Magox 400 tablet0.11USD tablet
Mag-oxide 400 mg tablet0.09USD tablet
Magnesium oxide powder heavy0.05USD g
Magnesium oxide 500 mg tablet0.04USD tablet
Maox 420 mg tablet0.04USD tablet
Magnesium oxide 250 mg tablet0.03USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8450338No2013-05-282028-10-10Us
US8481083No2013-07-092028-10-10Us
US9827231No2017-11-282034-06-23Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

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Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.57ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9838
Blood Brain Barrier+0.9837
Caco-2 permeable+0.6708
P-glycoprotein substrateNon-substrate0.8922
P-glycoprotein inhibitor INon-inhibitor0.9725
P-glycoprotein inhibitor IINon-inhibitor0.995
Renal organic cation transporterNon-inhibitor0.9248
CYP450 2C9 substrateNon-substrate0.8638
CYP450 2D6 substrateNon-substrate0.894
CYP450 3A4 substrateNon-substrate0.8026
CYP450 1A2 substrateNon-inhibitor0.8153
CYP450 2C9 inhibitorNon-inhibitor0.9268
CYP450 2D6 inhibitorNon-inhibitor0.9535
CYP450 2C19 inhibitorNon-inhibitor0.9338
CYP450 3A4 inhibitorNon-inhibitor0.9869
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9062
Ames testNon AMES toxic0.7478
CarcinogenicityCarcinogens 0.7198
BiodegradationReady biodegradable0.7705
Rat acute toxicity2.2618 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9031
hERG inhibition (predictor II)Non-inhibitor0.977
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on July 06, 2007 14:30 / Updated on November 16, 2019 10:36