Identification

Name
Magnesium carbonate
Accession Number
DB09481
Type
Small Molecule
Groups
Approved
Description

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].

Structure
Thumb
Synonyms
Not Available
External IDs
C.I. 77713
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cepasium Tab 100mgTablet100 mgOralLaboratoires Cortunon Inc.1979-12-312002-08-23Canada
Humco Dewees CarminativeSuspension50 mg/mLOralHumco Holding Group. Inc.1998-03-25Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acid Gone AntacidMagnesium carbonate (358 mg/15mL) + Aluminum hydroxide (95 mg/15mL)LiquidOralMajor2004-12-30Not applicableUs
Acid Gone Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralAvera Mc Kennan Hospital2015-07-09Not applicableUs
Acid Gone Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralMajor2014-06-06Not applicableUs
Aluminum hydroxide and Magnesium carbonateMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralSimpex Pharma Pvt. Ltd2012-11-15Not applicableUs
AntacidMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralMeijer Distribution1996-09-05Not applicableUs
Antacid - TabMagnesium carbonate (172.2 mg) + Calcium Carbonate (327.8 mg)TabletOralSwiss Herbal Remedies Ltd.1996-09-042003-09-10Canada
Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralRite Aid1997-08-07Not applicableUs
Aspirin Plus Stomach Guard Ext.stgth.capletMagnesium carbonate (52.3 mg) + Acetylsalicylic acid (500 mg) + Calcium Carbonate (246.2 mg) + Magnesium oxide (96.9 mg)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada
Aspirin Plus Stomach Guard Extra StrengthMagnesium carbonate (52.32 mg) + Acetylsalicylic acid (500 mg) + Calcium Carbonate (246.22 mg) + Magnesium oxide (96.95 mg)TabletOralBayer Inc Consumer Care1995-12-311998-09-28Canada
Aspirin Plus Stomach Guard TabMagnesium carbonate (34 mg) + Acetylsalicylic acid (325 mg) + Calcium Carbonate (160 mg) + Magnesium oxide (63 mg)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada
Categories
UNII
0IHC698356
CAS number
546-93-0
Weight
Average: 84.314
Monoisotopic: 83.969785764
Chemical Formula
CMgO3
InChI Key
ZLNQQNXFFQJAID-UHFFFAOYSA-L
InChI
InChI=1S/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name
magnesium(2+) ion carbonate
SMILES
[Mg++].[O-]C([O-])=O

Pharmacology

Indication

Used as an over the counter antacid [5].

Structured Indications
Pharmacodynamics

Neutralizes acid in the stomach [5].

Mechanism of action

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach [5].

TargetActionsOrganism
UGlutamate (NMDA) receptor
blocker
Human
Absorption

About 40-60% of magnesium is absorbed following oral administration [5]. Percent absorption decreases as dose increases.

Volume of distribution

Vd for magnesium is 0.2-0.4L/kg [5]. About 50% distributes to bone.

Protein binding

30% of magnesium is bound to proteins [5].

Metabolism

Magnesium does not appear to be metabolized in any way [5].

Route of elimination

Primarily eliminated in urine [5].

Half life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult [5].

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance [5].

Toxicity

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia [5].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [PubMed:26446763]
  2. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [PubMed:26069819]
  3. Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [PubMed:22261381]
  4. CDC NIOSH: MgCO3 [Link]
  5. Toxnet [Link]
External Links
KEGG Compound
C12893
ChemSpider
10563
ChEBI
31793
ChEMBL
CHEMBL1200736
ATC Codes
A02AA01 — Magnesium carbonateV03AE04 — Calcium acetate and magnesium carbonateA06AD01 — Magnesium carbonate
FDA label
Download (129 KB)
MSDS
Download (79.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceGastroesophageal Reflux Disease1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceHuman Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentHealthy Volunteers1
1RecruitingBasic ScienceGastroesophageal Reflux Disease1
4CompletedTreatmentEmergency / Indigestion / Pain1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidOral
TabletOral100 mg
SuspensionOral
Tablet, chewableOral
SuspensionOral50 mg/mL
GranuleOral
Tablet, film coatedOral
TabletOral
SolutionIrrigation
CapsuleOral
PowderOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)Decomposes at 350NIOSH [L781]
boiling point (°C)DecomposesNIOSH [L781]
water solubility0.1g/LNIOSH [L781]
Predicted Properties
PropertyValueSource
Water Solubility226.0 mg/mLALOGPS
logP0.52ALOGPS
logP0.25ChemAxon
logS0.21ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.17 m3·mol-1ChemAxon
Polarizability3.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Carbonate salt / Carbonic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organooxygen compound / Carbonyl group / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
magnesium salt, one-carbon compound, carbonate salt (CHEBI:31793)

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Unknown
Actions
Blocker
General Function
Voltage-gated cation channel activity
Specific Function
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic p...

Components:
References
  1. Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [PubMed:22261381]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Protein serine/threonine kinase activity
Specific Function
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the g...
Gene Name
TRPM6
Uniprot ID
Q9BX84
Uniprot Name
Transient receptor potential cation channel subfamily M member 6
Molecular Weight
231705.935 Da
References
  1. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [PubMed:26069819]
Kind
Protein
Organism
Homo sapiens
Pharmacological action
No
Actions
Substrate
General Function
Cation transmembrane transporter activity
Specific Function
Not Available
Gene Name
SLC41A3
Uniprot ID
Q96GZ6
Uniprot Name
Solute carrier family 41 member 3
Molecular Weight
54766.1 Da
References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [PubMed:26446763]
Kind
Protein
Organism
Homo sapiens
Pharmacological action
No
Actions
Substrate
General Function
Magnesium ion transmembrane transporter activity
Specific Function
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
Gene Name
CNNM2
Uniprot ID
Q9H8M5
Uniprot Name
Metal transporter CNNM2
Molecular Weight
96622.35 Da
References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [PubMed:26446763]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Protein serine/threonine kinase activity
Specific Function
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxi...
Gene Name
TRPM7
Uniprot ID
Q96QT4
Uniprot Name
Transient receptor potential cation channel subfamily M member 7
Molecular Weight
212695.37 Da
References
  1. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [PubMed:26069819]

Drug created on November 30, 2015 12:10 / Updated on October 02, 2017 06:16