Calcium Carbonate

Identification

Name
Calcium Carbonate
Accession Number
DB06724
Type
Small Molecule
Groups
Approved, Investigational
Description

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Structure
Thumb
Synonyms
  • Calcio carbonato
  • Calcium carbonate (1:1)
  • Calciumcarbonat
  • Carbonate de calcium
  • Carbonato de calcio
  • Carbonic acid calcium salt (1:1)
  • Chalk
  • Kalziumkarbonat
  • Kohlensaurer kalk
  • Precipitated calcium carbonate
External IDs
CI 77220 / E 170 / E-170(I) / INS NO.170(I) / INS-170(I) / NDI 443
Active Moieties
NameKindUNIICASInChI Key
CalciumunknownSY7Q814VUP7440-70-2OYPRJOBELJOOCE-UHFFFAOYSA-N
Carbonate ionionic7UJQ5OPE7D3812-32-6BVKZGUZCCUSVTD-UHFFFAOYSA-L
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Product Images
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select AntacidTablet, chewable750 mg/1Oral7 Eleven2014-09-11Not applicableUs
Alka SeltzerTablet, chewable750 mg/1OralBestco, Inc.2013-02-08Not applicableUs
Alka-Seltzer Extra Strength Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2016-09-15Not applicableUs
Alka-Seltzer Fruit ChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2013-03-152015-06-01Us
Alka-Seltzer Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-15Not applicableUs
Alka-Seltzer Heartburn ReliefChews Cool MintTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-05-31Us
Alka-Seltzer Heartburn ReliefChews StrawberryTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-08-31Us
Alka-Seltzer Heartburn ReliefChews Strawberry and OrangeTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-15Not applicableUs
Alka-Seltzer Ultra Strength Heartburn ReliefChewsTablet, chewable1000 mg/1OralBayer Healthcare Llc.2017-03-01Not applicableUs
Alkums antacidTablet, chewable500 mg/1OralGuardian Drug Company2012-02-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Gum Care ToothCalcium Carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic Acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
Acid Controller CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralShopko Stores Operating2013-06-052017-01-15Us
Acid Controller CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralSafeway2008-08-062017-01-19Us
Acid Controller CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralShopko Stores Operating2013-06-052016-11-16Us
Acid Controller Complete dual actionCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralWalgreen2008-07-302017-07-25Us
Acid Controller Complete dual actionCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralWalgreen2008-07-30Not applicableUs
Acid Reducer CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralWalgreen Company2016-01-29Not applicableUs
Acid Reducer CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralWalgreen Company2016-01-29Not applicableUs
Acid Reducer CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralRite Aid2009-05-152017-09-08Us
Acid Reducer CompleteCalcium Carbonate (800 mg/1) + Famotidine (10 mg/1) + Magnesium hydroxide (165 mg/1)Tablet, chewableOralShopko Stores Operating Co., LLC2016-01-06Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bal-Care DHACalcium Carbonate (219 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (.223 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
Bal-Care DHA EssentialCalcium Carbonate (219 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (.223 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
Calcium Folic Acid Plus D ChewableCalcium Carbonate (1342 mg/1) + Boron (250 ug/1) + Cholecalciferol (300 [iU]/1) + Cyanocobalamin (125 ug/1) + Folic Acid (1 mg/1) + Magnesium (50 mg/1) + Pyridoxine (10 mg/1)WaferOralAcella Pharmaceuticals, LLC2009-03-20Not applicableUs
Cavan AlphaCalcium Carbonate (230 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (220 ug/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30Us
Cavan Folate DHACalcium Carbonate (100 mg/1) + Calcium Carbonate (100 mg/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic Acid (1 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)KitSeton Pharmaceuticals2010-06-042012-03-31Us
Cavan Folate DHACalcium Carbonate (100 mg/1) + Calcium Carbonate (100 mg/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic Acid (1 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)KitSeton Pharmaceuticals2010-06-042012-03-31Us
Cavan Folate OBCalcium Carbonate (100 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (65 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1)TabletOralSeton Pharmaceuticals2010-08-232012-05-31Us
Cavan PrenatalCalcium Carbonate (200 mg/1) + Ascorbic acid (120 mg/1) + Cholecalciferol (420 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (8 ug/1) + Ferrous fumarate (28 mg/1) + Folic Acid (1 mg/1) + Niacin (20 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (15 ug/1)TabletOralSeton Pharmaceuticals2009-07-092009-07-22Us
Cavan-EC SOD DHACalcium Carbonate (230 mg/1) + Ascorbic acid (130 mg/1) + Beta carotene (3000 [iU]/1) + Cholecalciferol (410 [iU]/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (440 mg/1) + Pyridoxine hydrochloride (28 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (30 mg/1) + Zinc oxide (26 mg/1)KitOralPhysicians Total Care, Inc.2010-08-242013-01-15Us
Complete-RF PrenatalCalcium Carbonate (200 mg/1) + Ascorbic acid (120 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Docusate sodium (50 mg/1) + Folic Acid (1 mg/1) + Iron (90 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (25 mg/1)Tablet, film coatedOralTrigen Laboratories, Inc.2010-12-012013-03-31Us
Categories
UNII
H0G9379FGK
CAS number
471-34-1
Weight
Average: 100.087
Monoisotopic: 99.947335021
Chemical Formula
CCaO3
InChI Key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
InChI
InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name
calcium carbonate
SMILES
[Ca++].[O-]C([O-])=O

Pharmacology

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Associated Conditions
Associated Therapies
Pharmacodynamics

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Metabolism

None.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe therapeutic efficacy of Calcium Carbonate can be decreased when used in combination with (R)-warfarin.
(S)-WarfarinThe therapeutic efficacy of Calcium Carbonate can be decreased when used in combination with (S)-Warfarin.
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Calcium Carbonate is combined with 1alpha-Hydroxyvitamin D5.
2,5-Dimethoxy-4-ethylamphetamineCalcium Carbonate may decrease the excretion rate of 2,5-Dimethoxy-4-ethylamphetamine which could result in a higher serum level.
2,5-Dimethoxy-4-ethylthioamphetamineCalcium Carbonate may decrease the excretion rate of 2,5-Dimethoxy-4-ethylthioamphetamine which could result in a higher serum level.
3-Aza-2,3-Dihydrogeranyl DiphosphateCalcium Carbonate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3,4-MethylenedioxyamphetamineCalcium Carbonate may decrease the excretion rate of 3,4-Methylenedioxyamphetamine which could result in a higher serum level.
3,5-diiodothyropropionic acidThe therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Calcium Carbonate.
4-Bromo-2,5-dimethoxyamphetamineCalcium Carbonate may decrease the excretion rate of 4-Bromo-2,5-dimethoxyamphetamine which could result in a higher serum level.
4-hydroxycoumarinThe therapeutic efficacy of Calcium Carbonate can be decreased when used in combination with 4-hydroxycoumarin.
Food Interactions
  • Food increases the absorption of calcium carbonate.

References

Synthesis Reference

Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.

US5187125
General References
Not Available
External Links
KEGG Drug
D00932
KEGG Compound
C08129
PubChem Compound
10112
PubChem Substance
310264878
ChemSpider
9708
ChEBI
3311
ChEMBL
CHEMBL1200539
PharmGKB
PA448726
Wikipedia
Calcium_carbonate
ATC Codes
A11GB01 — Ascorbic acid (vit c) and calciumA12AA04 — Calcium carbonateA02AC01 — Calcium carbonate
AHFS Codes
  • 56:04.00 — Antacids and Adsorbents
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingPreventionMalignant Neoplasm of Colon1
1Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedBasic ScienceHuman Immunodeficiency Virus (HIV) Infections1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentDiabetic Nephropathies1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections3
1Not Yet RecruitingTreatmentBone Metastases / Sarcoma, Osteogenic1
2Active Not RecruitingBasic ScienceMetastatic Colorectal Cancers1
2CompletedPreventionAflatoxicosis1
2CompletedPreventionDietary Carcinogenesis1
2CompletedTreatmentDiabetic Nephropathies1
2CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
2CompletedTreatmentGaucher's Disease / Osteopenia1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHyperparathyroidism, Secondary / Renal Osteodystrophy1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentOsteopenia / Osteoporosis1
2CompletedTreatmentOsteoporosis / Postmenopausal Osteoporosis (PMO)1
2CompletedTreatmentRheumatoid Arthritis, Juvenile1
2RecruitingTreatmentHyperphosphataemia / Hyperphosphataemia in Chronic Kidney Disease1
2, 3CompletedPreventionAdenoma benign / Colorectal Cancers / Polyps1
3Active Not RecruitingTreatmentHemodialysis Treatment / Hyperphosphataemia1
3Active Not RecruitingTreatmentOsteopenia1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedTreatmentHyperphosphataemia1
3CompletedTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentOsteoporosis1
3Not Yet RecruitingTreatmentLiver Cirrhosis2
3RecruitingTreatmentAging / Pre-Diabetic1
3RecruitingTreatmentLiver Cirrhosis1
3TerminatedPreventionSevere or persistent diarrhea1
4Active Not RecruitingTreatmentTooth Bleaching / Tooth Sensitivity1
4CompletedTreatmentBMI >27 kg/m2 / BMI >30 kg/m21
4CompletedTreatmentCardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia1
4CompletedTreatmentEmergency / Indigestion / Pain NOS1
4CompletedTreatmentNutritional Rickets1
4CompletedTreatmentStage 3 Chronic Kidney Disease1
4Enrolling by InvitationTreatmentBone Diseases, Metabolic / Hyperphosphataemia / Renal Insufficiency,Chronic1
4Not Yet RecruitingTreatmentChronic Hypoparathyroidism1
4RecruitingTreatmentHyperphosphataemia1
4Unknown StatusTreatmentOther Nonspecific Abnormal Serum Enzyme Levels1
Not AvailableActive Not RecruitingSupportive CarePrimary Hyperparathyroidism1
Not AvailableCompletedPreventionChronic Kidney Disease (CKD)1
Not AvailableCompletedTreatmentCardiovascular Mortality1
Not AvailableCompletedTreatmentCystic Fibrosis (CF) / Osteoporosis1
Not AvailableCompletedTreatmentEnd Stage Renal Disease (ESRD) / Hemodialysis Treatment / Intimal Media Thickness1
Not AvailableCompletedTreatmentImpaired Renal Function1
Not AvailableCompletedTreatmentTransplant Bone Disease1
Not AvailableNot Yet RecruitingTreatmentType 2 Diabetes Mellitus1
Not AvailableRecruitingTreatmentDifferentiated Thyroid Cancer (DTC) / Osteoporosis1
Not AvailableWithdrawnTreatmentChronic Renal Failure (CRF) / End-Stage Renal Disease (ESRD) / Hyperphosphataemia / Insulin Resistance1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Paste, dentifriceOral
Kit
TabletOral1000 mg/1
TabletOral750 mg/1
Tablet, chewableOral750 1/1
LozengeOral750 mg/1
PasteDental36.4 g/130g
Powder, for solutionOral
Tablet, chewableOral500 mg/1
PowderOral1 g/1g
SuspensionOral1250 mg/5mL
TabletOral1250 mg/1
TabletOral648 mg/1
TabletOral1.5 g
TabletOral625 mg
TabletOral1.25 g
TabletOral500 mg/1
Tablet, chewableOral1177 mg/1
Tablet, chewableOral
Gum, chewingOral500 mg/1
GranuleOral750 mg/1g
SuspensionOral
KitOral
TabletOral1000 mg
LiquidOral1250 mg/40mL
SolutionOral1250 mg/34mL
LiquidOral
PowderOral1000 mg/1
Tablet, chewableOral350 mg/492mg
Tablet, coatedOral
Paste, dentifriceDental31.25 g/100g
Tablet, chewableOral750 mg/1
CapsuleOral
Tablet, chewableOral1000 mg/1
Tablet, chewableOral420 1/1
PasteDental
PasteDental51 g/150g
PowderOral
TabletOral250 mg
Tablet, chewableOral400 mg/1
TabletOral
Tablet, chewableOral420 mg/1
Tablet, film coatedOral
Capsule, gelatin coatedOral
PillOral
LiquidTopical
WaferOral
Paste, dentifriceTopical
Bar, chewableOral1177 mg/1
Bar, chewableOral
Tablet, chewableOral648 mg/1
PowderTopical
Paste, dentifriceDental15.85 g/100g
Paste, dentifriceDental
TabletOral420 mg/1
TabletOral420 mg
TabletOral500 mg
TabletOral750 mg
CreamOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6814978Yes2004-11-092022-02-26Us
US6165513Yes2000-12-262018-12-10Us
US5994329Yes1999-11-302019-01-17Us
US6015801Yes2000-01-182019-01-17Us
US6432932Yes2002-08-132019-01-17Us
US6465443Yes2002-10-152019-02-14Us
US5989588Yes1999-11-232018-03-30Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility128.0 mg/mLALOGPS
logP0.47ALOGPS
logP0.25ChemAxon
logS-0.08ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.17 m3·mol-1ChemAxon
Polarizability3.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic calcium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Carbonate salt / Carbonic acid / Organic calcium salt / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organooxygen compound / Carbonyl group / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
calcium salt, one-carbon compound, carbonate salt (CHEBI:3311)

Drug created on August 09, 2010 11:35 / Updated on November 20, 2018 00:56