Calcium carbonate

Identification

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Name
Calcium carbonate
Accession Number
DB06724
Type
Small Molecule
Groups
Approved, Investigational
Description

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Structure
Thumb
Synonyms
  • Calcio carbonato
  • Calcium carbonate (1:1)
  • Calciumcarbonat
  • Carbonate de calcium
  • Carbonato de calcio
  • Carbonic acid calcium salt (1:1)
  • Chalk
  • Kalziumkarbonat
  • Kohlensaurer kalk
  • Precipitated calcium carbonate
External IDs
CI 77220 / E 170 / E-170(I) / INS NO.170(I) / INS-170(I) / NDI 443
Active Moieties
NameKindUNIICASInChI Key
CalciumunknownSY7Q814VUP7440-70-2OYPRJOBELJOOCE-UHFFFAOYSA-N
Carbonate ionionic7UJQ5OPE7D3812-32-6BVKZGUZCCUSVTD-UHFFFAOYSA-L
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Product Images
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select AntacidTablet, chewable750 mg/1Oral7-Eleven2014-09-112020-05-01Us
Alka SeltzerTablet, chewable750 mg/1OralBestco, Inc.2013-02-08Not applicableUs
Alka-Seltzer Cool Action Extra Strength ReliefChews MintTablet, chewable750 mg/1OralBayer Healthcare Llc.2019-03-03Not applicableUs
Alka-Seltzer Extra Strength Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2016-09-15Not applicableUs
Alka-Seltzer Fruit ChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2013-03-152015-06-01Us
Alka-Seltzer Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-15Not applicableUs
Alka-Seltzer Heartburn ReliefChews Cool MintTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-05-31Us
Alka-Seltzer Heartburn ReliefChews StrawberryTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-08-31Us
Alka-Seltzer Heartburn ReliefChews Strawberry and OrangeTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-15Not applicableUs
Alka-Seltzer Ultra Strength Heartburn ReliefChewsTablet, chewable1000 mg/1OralBayer Healthcare Llc.2017-03-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Gum Care ToothCalcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
4240 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4248 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4327 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4329 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitTopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4338 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4339 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4346 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4356 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)OralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4390 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)OralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Gum Care ToothCalcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
4240 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4248 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4327 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4329 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitTopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4338 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4339 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4346 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)KitOralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4356 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)OralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4390 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)OralHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
Categories
UNII
H0G9379FGK
CAS number
471-34-1
Weight
Average: 100.087
Monoisotopic: 99.947335021
Chemical Formula
CCaO3
InChI Key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
InChI
InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name
calcium carbonate
SMILES
[Ca++].[O-]C([O-])=O

Pharmacology

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Associated Conditions
Associated Therapies
Pharmacodynamics

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Metabolism

None.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe therapeutic efficacy of Calcium carbonate can be decreased when used in combination with (R)-warfarin.
(S)-WarfarinThe therapeutic efficacy of Calcium carbonate can be decreased when used in combination with (S)-Warfarin.
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Calcium Carbonate is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2The risk or severity of adverse effects can be increased when Calcium Carbonate is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Calcium carbonate.
2,5-Dimethoxy-4-ethylthioamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Calcium carbonate.
3-Aza-2,3-Dihydrogeranyl DiphosphateCalcium carbonate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamineThe serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Calcium carbonate.
4-hydroxycoumarinThe therapeutic efficacy of Calcium carbonate can be decreased when used in combination with 4-hydroxycoumarin.
AbafunginCalcium carbonate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
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    Extended Description

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  • Severity
    Severity

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    Evidence Level

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Food Interactions
  • Food increases the absorption of calcium carbonate.

References

Synthesis Reference

Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.

US5187125
General References
Not Available
External Links
KEGG Drug
D00932
KEGG Compound
C08129
PubChem Compound
10112
PubChem Substance
310264878
ChemSpider
9708
ChEBI
3311
ChEMBL
CHEMBL1200539
PharmGKB
PA448726
Wikipedia
Calcium_carbonate
ATC Codes
A02AC01 — Calcium carbonateA12AA04 — Calcium carbonateA11GB01 — Ascorbic acid (vit c) and calcium
AHFS Codes
  • 56:04.00 — Antacids and Adsorbents
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingPreventionMalignant Neoplasm of Colon1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedTreatmentDiabetic Nephropathies1
1CompletedTreatmentHeartburn1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
1Not Yet RecruitingTreatmentBone Metastases / Sarcoma, Osteogenic1
1Not Yet RecruitingTreatmentCastrate Resistant Prostate Cancer With Bone Metastasis1
1RecruitingTreatmentOncology1
1RecruitingTreatmentSolid Malignancies, With or Without Lung Metastases1
1, 2CompletedPreventionImpaired Glucose Tolerance / Metabolic Syndromes / Type 2 Diabetes Mellitus1
1, 2CompletedTreatmentRetinal Vein Occlusions(RVO)1
2Active Not RecruitingBasic ScienceMetastatic Colorectal Cancers1
2CompletedPreventionAflatoxicosis1
2CompletedPreventionDietary Carcinogenesis1
2CompletedTreatmentChronic Kidney Disease (CKD) / Hyperphosphataemia / Hyperphosphataemia in Chronic Kidney Disease1
2CompletedTreatmentDiabetic Nephropathies1
2CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
2CompletedTreatmentEvaluation of Expected Bone Loss After Bariatric Surgery / Possible Prevention of Bone Loss After Surgery by Calcium and Vitamin D Supplementation1
2CompletedTreatmentGaucher's Disease / Osteopenia1
2CompletedTreatmentHeartburn1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHuman Immunodeficiency Virus Type 1 (HIV-1) Infection1
2CompletedTreatmentHyperparathyroidism, Secondary / Renal Osteodystrophy1
2CompletedTreatmentOsteopenia / Osteoporosis1
2CompletedTreatmentOsteoporosis / Postmenopausal Osteoporosis (PMO)1
2CompletedTreatmentRheumatoid Arthritis, Juvenile1
2, 3CompletedPreventionAdenoma benign / Colorectal Cancers / Polyps1
3Active Not RecruitingTreatmentAging / Pre-Diabetic1
3Active Not RecruitingTreatmentOsteopenia1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedSupportive CareBreast Cancer / Osteoporosis1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Osteoporosis1
3CompletedTreatmentHemodialysis Treatment / Hyperphosphataemia1
3CompletedTreatmentHyperphosphataemia1
3CompletedTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentOsteoporosis2
3CompletedTreatmentPostmenopausal Osteoporosis (PMO)1
3Not Yet RecruitingTreatmentLiver Cirrhosis2
3RecruitingTreatmentLiver Cirrhosis1
3TerminatedPreventionDiarrhea1
4CompletedPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4CompletedTreatmentBMI >27 kg/m2 / BMI >30 kg/m21
4CompletedTreatmentCardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia1
4CompletedTreatmentDiabetic Macular Edema (DME)1
4CompletedTreatmentNutritional Rickets1
4CompletedTreatmentStage 3 Chronic Kidney Disease1
4CompletedTreatmentTooth Bleaching / Tooth Sensitivity1
4Enrolling by InvitationTreatmentBone Diseases, Metabolic / Hyperphosphataemia / Renal Insufficiency,Chronic1
4Not Yet RecruitingTreatmentAmenorrhea / Endometriosis / Quality of Life1
4Not Yet RecruitingTreatmentChronic Hypoparathyroidism1
4Not Yet RecruitingTreatmentSjögren's Syndrome1
4RecruitingTreatmentHyperphosphataemia1
4Unknown StatusTreatmentOther Nonspecific Abnormal Serum Enzyme Levels1
Not AvailableCompletedNot AvailableHypoparathyroidism Postprocedural1
Not AvailableCompletedOtherBubbles in Colon at Time of Colonoscopy1
Not AvailableCompletedPreventionChronic Kidney Disease (CKD)1
Not AvailableCompletedSupportive CarePrimary Hyperparathyroidism1
Not AvailableCompletedTreatmentCardiovascular Mortality1
Not AvailableCompletedTreatmentCystic Fibrosis (CF) / Osteoporosis1
Not AvailableCompletedTreatmentEnd Stage Renal Disease (ESRD) / Hemodialysis Treatment / Intimal Media Thickness1
Not AvailableCompletedTreatmentImpaired Renal Function1
Not AvailableCompletedTreatmentTransplant Bone Disease1
Not AvailableRecruitingTreatmentDifferentiated Thyroid Cancer (DTC) / Osteoporosis1
Not AvailableUnknown StatusTreatmentType 2 Diabetes Mellitus1
Not AvailableWithdrawnTreatmentChronic Renal Failure (CRF) / End-Stage Renal Disease (ESRD) / Hyperphosphataemia / Insulin Resistance1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Paste, dentifriceOral
KitOphthalmic
KitTopical
KitOral
TabletOral1000 mg/1
TabletOral750 mg/1
Tablet, chewableOral750 1/1
LozengeOral750 mg/1
PasteDental36.4 g/130g
Powder, for solutionOral
Tablet, chewableOral500 mg/1
TabletOral600 mg/1
PowderOral1 g/1g
SuspensionOral1250 mg/5mL
TabletOral1250 mg/1
TabletOral648 mg/1
TabletOral500 mg/1
Tablet, chewableOral1177 mg/1
Gum, chewingOral500 mg/1
GranuleOral750 mg/1g
PowderOral
LiquidOral1250 mg/40mL
SolutionOral1250 mg/34mL
SuspensionOral
Tablet, chewableOral
Tablet, chewableOral750 mg/1
PowderOral1000 mg/1
Tablet, film coatedOral600 mg/1
PasteOral
Tablet, chewableOral350 mg/492mg
Tablet, coatedOral
Paste, dentifriceDental31.25 g/100g
CapsuleOral
Tablet, chewableOral420 1/1
PasteDental
PasteDental51 g/150g
Tablet, coatedOral500 mg/1
Tablet, chewableOral400 mg/1
Tablet, chewableOral420 mg/1
Tablet, film coatedOral
Capsule, gelatin coatedOral
PillOral
LiquidTopical
TabletOral
WaferOral
Paste, dentifriceTopical
Bar, chewableOral1177 mg/1
Bar, chewableOral
LiquidOral
Tablet, chewableOral648 mg/1
PowderTopical
Paste, dentifriceDental15.85 g/100g
Paste, dentifriceDental
Tablet, chewableOral1000 mg/1
TabletOral420 mg/1
TabletOral
CreamOral
Capsule, liquid filledOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6814978Yes2004-11-092022-02-26Us
US6165513Yes2000-12-262018-12-10Us
US5994329Yes1999-11-302019-01-17Us
US6015801Yes2000-01-182019-01-17Us
US6432932Yes2002-08-132019-01-17Us
US6465443Yes2002-10-152019-02-14Us
US5989588Yes1999-11-232018-03-30Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility128.0 mg/mLALOGPS
logP0.47ALOGPS
logP0.25ChemAxon
logS-0.08ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.17 m3·mol-1ChemAxon
Polarizability3.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic calcium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Carbonate salt / Carbonic acid / Organic calcium salt / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organooxygen compound / Carbonyl group / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
calcium salt, one-carbon compound, carbonate salt (CHEBI:3311)

Drug created on August 09, 2010 11:35 / Updated on November 16, 2019 10:41