Miscellaneous Anticonvulsants

DrugDrug NameDrug Description
DB00230PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DB00313Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB00564CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DB00653Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
DB00776OxcarbazepineAn anti-epileptic used in the treatment of partial-onset seizures.
DB00996GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
DB01080VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct to treat refractory complex partial seizures in patients ≥10 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
DB01202LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
DB05541BrivaracetamAn anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain.
DB06201RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
DB06218LacosamideAn antiepileptic drug used to treat partial onset seizures in adults.
DB08883PerampanelA non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.
DB09118StiripentolAn anticonvulsant agent used with clobazam and valproate as an adjunct to treat refractory generalized tonic-clonic seizures in Dravet syndrome.
DrugDrug NameTargetType
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateVoltage-gated sodium channel alpha subunittarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateKainate receptorstarget
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateVoltage gated L-type calcium channeltarget
DB00273TopiramateVoltage-dependent R-type calcium channeltarget
DB00273TopiramateSerum albumincarrier
DB00273TopiramateP-glycoprotein 1transporter
DB00273Topiramate5'-AMP-activated protein kinasetransporter
DB00313Valproic acidHistone deacetylase 9target
DB00313Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic acidCytochrome P450 2A6enzyme
DB00313Valproic acidCytochrome P450 2B6enzyme
DB00313Valproic acidCytochrome P450 2C9enzyme
DB00313Valproic acidSolute carrier family 22 member 5transporter
DB00313Valproic acidSolute carrier family 22 member 6transporter
DB00313Valproic acidSolute carrier family 22 member 8transporter
DB00313Valproic acidMonocarboxylate transporter 1transporter
DB00313Valproic acidSolute carrier family 22 member 7transporter
DB00313Valproic acidCytochrome P450 3A5enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic acidProstaglandin G/H synthase 1enzyme
DB00313Valproic acidCytochrome P450 1A2enzyme
DB00313Valproic acidCytochrome P450 2C19enzyme
DB00313Valproic acidCytochrome P450 3A4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic acidSodium channel proteintarget
DB00313Valproic acidHistone deacetylase 2target
DB00313Valproic acidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic acidSerum albumincarrier
DB00313Valproic acidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic acidSolute carrier organic anion transporter family member 2B1transporter
DB00555LamotrigineSodium channel protein type 2 subunit alphatarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-4enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineUDP-glucuronosyltransferase 1-3enzyme
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA-A receptor (anion channel)target
DB00555LamotrigineGABA-A receptor (benzodiazepine site)target
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineMuscarinic acetylcholine receptortarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineUDP-glucuronosyltransferase 1-1enzyme
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00564CarbamazepineVoltage-gated sodium channel alpha subunittarget
DB00564CarbamazepineCytochrome P450 2C8enzyme
DB00564CarbamazepineCytochrome P450 2B6enzyme
DB00564CarbamazepineCytochrome P450 3A4enzyme
DB00564CarbamazepineCytochrome P450 1A2enzyme
DB00564CarbamazepineCytochrome P450 2C19enzyme
DB00564CarbamazepineCytochrome P450 2C9enzyme
DB00564CarbamazepineP-glycoprotein 1transporter
DB00564CarbamazepineCytochrome P450 3A5enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
DB00564CarbamazepineRalA-binding protein 1transporter
DB00564CarbamazepineCanalicular multispecific organic anion transporter 1transporter
DB00564CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
DB00564CarbamazepineNuclear receptor subfamily 1 group I member 2target
DB00564CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00776OxcarbazepineCytochrome P450 2C19enzyme
DB00776OxcarbazepineCytochrome P450 3A4enzyme
DB00776OxcarbazepineCytochrome P450 3A5enzyme
DB00776OxcarbazepineSerum albumincarrier
DB00776OxcarbazepineP-glycoprotein 1transporter
DB00776OxcarbazepineAldo-keto reductase family 1 member C1enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C2enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C3enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C4enzyme
DB00776OxcarbazepineCarbonyl reductase [NADPH] 1enzyme
DB00776OxcarbazepineCarbonyl reductase [NADPH] 3enzyme
DB00776OxcarbazepineSodium channel proteintarget
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinLarge neutral amino acids transporter small subunit 1transporter
DB00996GabapentinVoltage-dependent N-type calcium channeltarget
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 3target
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 5target
DB01080Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
DB01080VigabatrinGamma-aminobutyric acid type B receptor subunit 1target
DB01080VigabatrinProton-coupled amino acid transporter 1transporter
DB01080VigabatrinCytochrome P450 2C9enzyme
DB01202LevetiracetamSynaptic vesicle glycoprotein 2Atarget
DB01202LevetiracetamP-glycoprotein 1transporter
DB01202LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB05541BrivaracetamSynaptic vesicle glycoprotein 2Atarget
DB05541BrivaracetamSodium channel proteintarget
DB05541BrivaracetamCytochrome P450 3A4enzyme
DB05541BrivaracetamCytochrome P450 2C19enzyme
DB05541BrivaracetamCytochrome P450 2B6enzyme
DB05541BrivaracetamCytochrome P450 2C9enzyme
DB06201RufinamideMetabotropic glutamate receptor 5target
DB06201RufinamideLiver carboxylesterase 1enzyme
DB06201RufinamideSodium channel protein type 9 subunit alphatarget
DB06201RufinamideSerum albumincarrier
DB06201RufinamideCytochrome P450 2E1enzyme
DB06201RufinamideCytochrome P450 3A4enzyme
DB06218LacosamideSodium channel protein type 9 subunit alphatarget
DB06218LacosamideSodium channel protein type 3 subunit alphatarget
DB06218LacosamideSodium channel protein type 10 subunit alphatarget
DB06218LacosamideCytochrome P450 2C19enzyme
DB06218LacosamideCytochrome P450 2C9enzyme
DB06218LacosamideCytochrome P450 3A4enzyme
DB08883PerampanelGlutamate receptor 1target
DB08883PerampanelCytochrome P450 3A4enzyme
DB08883PerampanelCytochrome P450 3A5enzyme
DB08883PerampanelCytochrome P450 1A2enzyme
DB08883PerampanelCytochrome P450 2B6enzyme
DB09118StiripentolCytochrome P450 2C19enzyme
DB09118StiripentolCytochrome P450 2D6enzyme
DB09118StiripentolCytochrome P450 3A4enzyme
DB09118StiripentolCytochrome P450 1A2enzyme
DB09118StiripentolCytochrome P450 2C9enzyme
DB09118StiripentolGABA-A receptor (anion channel)target
DB09118StiripentolL-lactate dehydrogenase A chaintarget
DB09118StiripentolL-lactate dehydrogenase B chaintarget