|DB00230||Pregabalin||Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjunctive therapy for adult patients with partial onset seizures [FDA label]. |
|DB00273||Topiramate||Topiramate is indicated for the following conditions:
- Monotherapy for partial onset or primary generalized tonic-clonic seizures in patients over 2 years of age.
- Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for adult and pediatric patients.
- Adjunctive therapy for seizures associated with Lennox-Gastaut syndrome in patients over 2 years of age.
- Prophylaxis of migraine headache in adults.[FDA label]
A seizure is an abnormal, unregulated electrical discharge occurring in the brain's cortical gray matter. This electrical response produces a transient interruption in the normal brain function which in order produces altered awareness, abnormal sensations, focal involuntary movements or convulsions. The type of seizure can be classified according to the type of onset followed by a type of seizure.[L5548]
A migraine headache is a [ulsating or throbbing pain that can be presented in one of both sides of the head and it can be worsened by external stimuli such as physical activity, light, sounds, and odors.[L5551]
Topiramate has been commonly investigated and used off-label for weight reduction in patients with obesity or diabetes.[A175240]|
|DB00313||Valproic Acid||**Indicated** for:[Label]
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
**Off-label** uses include:
1) Maintenance therapy for bipolar disorder.[A177919]
2) Treatment for acute bipolar depression.[A177928,A177931,A177934]
3) Emergency treatment of status epilepticus.[A177955]|
|DB00555||Lamotrigine||Indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures/primary generalized tonic-clonic seizures/generalized seizures of Lennox-Gastaut syndrome [FDA Label].
Indicated for conversion to monotherapy in adults (≥16 years of age) with partial seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED)[FDA Label].
Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].|
|DB00564||Carbamazepine||Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia.[L1335] In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures.[A180301,L1335] Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder.[L1335] Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.[A180415,A180421]|
|DB00653||Magnesium sulfate||Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.|
|DB00776||Oxcarbazepine||For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.|
|DB00996||Gabapentin||For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.|
|DB01080||Vigabatrin||For use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome.|
|DB01202||Levetiracetam||Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.|
|DB05541||Brivaracetam||Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.|
|DB06201||Rufinamide||Adjunct therapy for treatment of seizures associated with Lennox-Gastaut syndrome. |
|DB06218||Lacosamide||Lacosamide is indicated for adjunctive therapy for partial onset seizures in patients with epilepsy over 17 years old. Injection is indicated for short term use when oral therapy is not feasible. |
|DB08883||Perampanel||Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.|
|DB09118||Stiripentol||Indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy in infancy (SMEI, Dravet’s syndrome) whose seizures are not adequately controlled with clobazam and valproate.|