Identification

Name
Stiripentol
Accession Number
DB09118
Type
Small Molecule
Groups
Approved
Description

Stiripentol is an anticonvulsant drug used in the treatment of epilepsy as an adjunct therapy along with Clobazam and Valproic Acid. Unrelated to other anticonvulsants, stitipentol belongs to the group of aromatic allylic alcohols and may potentiate the effect of other antiepileptic drugs (AEDs) due to pharmacokinetic interactions. It elevates the levels of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter that regulates electrical activity in the central nervous system. Use of stiripentol is approved for infants with Dravet syndrome, or Severe Myoclonic Epilepsy in Infancy (SMEI) that commonly occurs at the first year of life. Stiripentol is not FDA-approved but approved in Canada and European countries as oral tablets marketed as Diacomit.

Structure
Thumb
Synonyms
  • 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol
  • 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-ol
  • BCX 2600
  • BRN 1313047
  • Estiripentol
  • Stiripentolum
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DiacomitCapsule250 mgOralBiocodex Sa2013-05-01Not applicableCanada
DiacomitPowder, for suspension500 mgOralBiocodex2007-01-04Not applicableEu
DiacomitCapsule500 mgOralBiocodex2007-01-04Not applicableEu
DiacomitPowder, for suspension250 mgOralBiocodex2007-01-04Not applicableEu
DiacomitCapsule250 mgOralBiocodex2007-01-04Not applicableEu
DiacomitPowder, for suspension500 mgOralBiocodex Sa2013-05-01Not applicableCanada
DiacomitCapsule500 mgOralBiocodex2007-01-04Not applicableEu
DiacomitCapsule500 mgOralBiocodex Sa2013-05-01Not applicableCanada
DiacomitPowder, for suspension500 mgOralBiocodex2007-01-04Not applicableEu
DiacomitPowder, for suspension250 mgOralBiocodex2007-01-04Not applicableEu
Categories
UNII
R02XOT8V8I
CAS number
49763-96-4
Weight
Average: 234.295
Monoisotopic: 234.12559444
Chemical Formula
C14H18O3
InChI Key
IBLNKMRFIPWSOY-FNORWQNLSA-N
InChI
InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
IUPAC Name
(1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
SMILES
CC(C)(C)C(O)\C=C\C1=CC2=C(OCO2)C=C1

Pharmacology

Indication

Indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy in infancy (SMEI, Dravet’s syndrome) whose seizures are not adequately controlled with clobazam and valproate.

Structured Indications
Pharmacodynamics

Stiripentol is an orphan drug that effectively reduces seizure frequency in infantile epilepsy as an adjunct therapy and also exhibits a therapeutic advantage in improving the efficacy of other antiepileptic drugs. It potentiates GABA transmission by elevating the levels of the inhibitory neurotransmitters in the brain [2]. Stiripentol is a positive allosteric modulator of GABA-A receptors in the brain that enhances the opening duration of the channel by binding to a site different than the benzodiazepine binding site [1]. Reduced synaptosomal uptake of GABA and/or inhibition of GABA transaminase may also explain the role of stiripentol in reducing the events of seizure [5]. The anticonvulsant activity of stiripentol is age-dependent, with increased efficacy in younger patients [4].

Mechanism of action

Stiripentol enhances GABAergic inhibition and prolongs the open duration of GABA-A receptor chloride channels by a barbiturate-like mechanism [5]. It binds to GABA-A receptors containing any of the α, β, γ, or δ-subunits but displays strongest potency when bound to receptors containing α3 or δ subunits [4]. Stiripentol is an inhibitor of lactate dehydrogenase (LDH), which plays a physiological role in energy metabolism of neurons and regulation of neuronal excitation. It binds to the site separate from lactate and pyruvate binding sites of the enzyme and inhibits both pyruvate-to-lactate conversion and lactate-to-pyruvate conversion [3]. LDH inhibitors including stiripentol as antiepileptic treatments mimic ketogenic diet, where the energy source in the brain is switched from glucose to mainly ketone bodies. The ketone bodies directly regulate neuronal excitation and seizures via ATP-sensitive potassium channels and vesicular glutamate transporters [3]. As a potent inhibitor of hepatic cytochrome P450 enzymes, mainly CYP3A4 and CYP2C19, stiripentol co-administration with other antiepileptic drugs elevates the free unchanged active drugs (such as carbamazepine, sodium valproate, phenytoin, phenobarbital and many benzodiazepines) in the circulation to mediate their therapeutic actions.

TargetActionsOrganism
AGABA-A receptor (anion channel)
agonist
positive allosteric modulator
Human
AL-lactate dehydrogenase A chain
inhibitor
Human
AL-lactate dehydrogenase B chain
inhibitor
Human
Absorption

Absorption of stiripentol is quick with the peak plasma concentration reached within 1.5 hours following oral administration. The systemic exposure increases in a dose-proportional relationship [5]. It is rapidly taken up into the brain and enters the cerebellum and medulla. It displays low bioavailability due to water insolubility and metabolism [2].

Volume of distribution

The average volume of distribution is 1.03 L/kg but does not display a dose-dependent relationship. It is expected to be distributed into the extravascular space and with a high degree of tissue binding [2].

Protein binding

Stiripentol binds extensively to circulating plasma proteins (about 99%) [5].

Metabolism

There are 13 metabolites from extensive metabolism stiripentol that are found in urine. The predominant metabolic pathways involve demethylenation and glucuronidation. Other metabolic pathways are oxidative cleavage of the methylenedioxy ring system, O-methylation of catechol metabolites, hydroxylation of the t-butyl group and conversion of the allylic alcohol side-chain to the isomeric 3-pentanone structure [2]. Based on in vitro studies, phase I metabolism of stiripentol involves enzymatic activity of CYP1A2, CYP2C19 and CYP3A4 [5].

Route of elimination

Renal elimination is mainly responsible for excretion of stiripentol. About 73% of total administered dose is found in urine as metabolites, while further 13-24% of the total dose is recovered in faeces as unchanged substance [5].

Half life

Elimination half life is approximately ranges from 4.5 to 13 hours, in a dose-dependent manner [5].

Clearance

Plasma clearance decreases markedly at high doses; it falls from approximately 40 L/kg/day at the dose of 600 mg/day to about 8 L/kg/day at the dose of 2,400 mg [5]. Decreased clearance is probably explained by inhibition of the cytochrome P450 isoenzymes that catalyzes stiripentol metabolism [5].

Toxicity

Most common adverse effects include anorexia, loss of appetite, nausea, vomiting, weight loss, reversible neutropenia, insomnia, drowsiness, ataxia, dystonia, hyperkinesia, hypotonia. Aggression, irritability, behaviour disorders, opposing behaviour, hyper excitability and sleep disorders may also be observed. Stiripentol does not demonstrate teratogenic, mutagenic, clastogenic, or carcinogenic potential [5]. Oral LD50 in rats is >3 g/kg [MSDS].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Stiripentol.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Stiripentol.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Stiripentol.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Stiripentol.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Stiripentol.Experimental
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Stiripentol.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Stiripentol.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Stiripentol.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Stiripentol.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Stiripentol.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Stiripentol.Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Stiripentol.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Stiripentol.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Stiripentol.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Stiripentol.Approved
AlaproclateThe risk or severity of adverse effects can be increased when Stiripentol is combined with Alaproclate.Experimental
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Stiripentol.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Stiripentol.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Stiripentol.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Stiripentol.Vet Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Stiripentol.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Stiripentol.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Stiripentol.Approved, Investigational
AllopregnanoloneThe risk or severity of adverse effects can be increased when Allopregnanolone is combined with Stiripentol.Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Stiripentol.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Stiripentol.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Stiripentol.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Stiripentol.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Stiripentol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Stiripentol.Illicit
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Stiripentol.Approved, Withdrawn
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Stiripentol.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Stiripentol.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Stiripentol.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Stiripentol.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Stiripentol.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Stiripentol.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Stiripentol.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Stiripentol.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Stiripentol.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Stiripentol.Approved, Illicit
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Stiripentol.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Stiripentol.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Stiripentol.Approved, Vet Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Stiripentol.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Stiripentol.Approved, Illicit
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Stiripentol.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Stiripentol.Approved
AndrostenedioneThe serum concentration of Androstenedione can be increased when it is combined with Stiripentol.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Stiripentol.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be increased when it is combined with Stiripentol.Investigational
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Stiripentol.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Stiripentol.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Stiripentol.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Stiripentol.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Stiripentol.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Stiripentol.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Stiripentol.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Stiripentol.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Stiripentol.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Stiripentol.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Stiripentol.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Stiripentol.Approved, Withdrawn
AtamestaneThe serum concentration of Atamestane can be increased when it is combined with Stiripentol.Investigational
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Stiripentol.Approved, Investigational
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Stiripentol.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Stiripentol.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Stiripentol.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Stiripentol.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Stiripentol.Vet Approved
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Stiripentol.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Stiripentol.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Stiripentol.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Stiripentol.Investigational
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Stiripentol.Illicit
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Stiripentol.Approved
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Stiripentol.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Stiripentol.Approved
BenperidolThe risk or severity of adverse effects can be increased when Benperidol is combined with Stiripentol.Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Stiripentol.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Stiripentol.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Stiripentol.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Stiripentol.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Stiripentol.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Stiripentol.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Stiripentol.Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Stiripentol.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Stiripentol.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Stiripentol.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Stiripentol.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Stiripentol.Withdrawn
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Stiripentol.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Stiripentol.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Stiripentol.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Stiripentol.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Stiripentol.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Stiripentol.Approved
BrivaracetamThe serum concentration of Brivaracetam can be increased when it is combined with Stiripentol.Approved, Investigational
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Stiripentol.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Bromisoval is combined with Stiripentol.Experimental
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Stiripentol.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Bromperidol is combined with Stiripentol.Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Stiripentol.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Stiripentol.Approved, Withdrawn
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Stiripentol.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Stiripentol.Experimental, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Stiripentol.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Stiripentol.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Stiripentol.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Stiripentol.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Stiripentol.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Stiripentol.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Stiripentol.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Stiripentol.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Stiripentol.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Stiripentol.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Stiripentol.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Stiripentol.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Stiripentol.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Stiripentol.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Stiripentol.Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Stiripentol.Investigational
CaptoprilThe metabolism of Captopril can be decreased when combined with Stiripentol.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Stiripentol.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Stiripentol.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Stiripentol.Illicit, Vet Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Stiripentol.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Stiripentol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Stiripentol.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Stiripentol.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Stiripentol.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Stiripentol.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Stiripentol.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Stiripentol.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Stiripentol.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Stiripentol.Approved
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Stiripentol.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Stiripentol.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Stiripentol.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Stiripentol.Approved, Vet Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Stiripentol.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Stiripentol.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Stiripentol.Approved
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Stiripentol.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Stiripentol.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Stiripentol.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Stiripentol.Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Stiripentol.Approved, Withdrawn
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Stiripentol.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Stiripentol.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Stiripentol.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Stiripentol.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Stiripentol.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Stiripentol.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Stiripentol.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Stiripentol.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Stiripentol.Approved
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Stiripentol.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Stiripentol.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Stiripentol.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Stiripentol.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Stiripentol.Approved, Vet Approved
ClobazamThe serum concentration of Stiripentol can be increased when it is combined with Clobazam.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Stiripentol.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Stiripentol.Approved
ClobetasoneThe serum concentration of Clobetasone can be increased when it is combined with Stiripentol.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Stiripentol.Approved
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Stiripentol.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Stiripentol.Approved
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Stiripentol.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Stiripentol.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Stiripentol.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Stiripentol.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Clopenthixol is combined with Stiripentol.Experimental
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Stiripentol.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Stiripentol.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Clothiapine is combined with Stiripentol.Experimental
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Stiripentol.Approved, Illicit
ClotrimazoleThe metabolism of Stiripentol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Stiripentol.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Stiripentol.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Stiripentol.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Stiripentol.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Stiripentol.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Stiripentol.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Stiripentol.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Stiripentol.Approved
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Stiripentol.Investigational
CorticosteroneThe serum concentration of Corticosterone can be increased when it is combined with Stiripentol.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Stiripentol.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Stiripentol.Approved
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Stiripentol.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Stiripentol.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Stiripentol.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Stiripentol.Approved
Cyproterone acetateThe serum concentration of Stiripentol can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Stiripentol.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Stiripentol.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Stiripentol.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Stiripentol.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Stiripentol.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Stiripentol.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Stiripentol.Investigational
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Stiripentol.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Stiripentol.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Stiripentol.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Stiripentol.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Stiripentol.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Stiripentol.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Stiripentol.Approved
DeferasiroxThe serum concentration of Stiripentol can be increased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Stiripentol.Approved
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Stiripentol.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Stiripentol.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Stiripentol.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Stiripentol.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Stiripentol.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Stiripentol.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Stiripentol.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Stiripentol.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Stiripentol.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Stiripentol.Vet Approved
DeutetrabenazineThe serum concentration of Deutetrabenazine can be increased when it is combined with Stiripentol.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Stiripentol.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Stiripentol.Approved
Dexchlorpheniramine maleateThe serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Stiripentol.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Stiripentol.Approved, Illicit, Withdrawn
DexlansoprazoleThe serum concentration of Dexlansoprazole can be increased when it is combined with Stiripentol.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Stiripentol.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Stiripentol.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Stiripentol.Approved, Illicit
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Stiripentol.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Stiripentol.Experimental, Illicit
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Stiripentol.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Stiripentol.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Stiripentol.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Stiripentol.Approved, Vet Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Stiripentol.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Diethyl ether is combined with Stiripentol.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Stiripentol.Approved, Illicit
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Stiripentol.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Stiripentol.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Stiripentol.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Stiripentol.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Stiripentol.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Stiripentol.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Stiripentol.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Stiripentol.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Stiripentol.Experimental
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Stiripentol.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Stiripentol.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Stiripentol.Experimental, Illicit
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Stiripentol.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Stiripentol.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Stiripentol.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Stiripentol.Approved, Illicit
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Stiripentol.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Stiripentol.Approved
DixyrazineThe risk or severity of adverse effects can be increased when Dixyrazine is combined with Stiripentol.Experimental
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Stiripentol.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Stiripentol.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Stiripentol.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Stiripentol.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Stiripentol.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Stiripentol.Vet Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Stiripentol.Approved
DosulepinThe metabolism of Stiripentol can be decreased when combined with Dosulepin.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Stiripentol.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Stiripentol.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Stiripentol.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Stiripentol.Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Stiripentol.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Stiripentol.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Stiripentol.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Stiripentol.Experimental, Illicit
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Stiripentol.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Stiripentol.Approved, Investigational
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Stiripentol.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Stiripentol.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Ecopipam is combined with Stiripentol.Investigational
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Stiripentol.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Stiripentol.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Stiripentol.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Stiripentol.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Eltanolone is combined with Stiripentol.Investigational
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Stiripentol.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Stiripentol.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be increased when it is combined with Stiripentol.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Stiripentol.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Stiripentol.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Stiripentol.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Stiripentol.Approved, Investigational
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Stiripentol.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Stiripentol.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Stiripentol.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Stiripentol.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Stiripentol.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Stiripentol.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Stiripentol.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Stiripentol.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Stiripentol.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Stiripentol.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Stiripentol.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Stiripentol.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Stiripentol.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Stiripentol.Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Stiripentol.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Stiripentol.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Stiripentol.Approved
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Stiripentol.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Stiripentol.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Stiripentol.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Stiripentol.Approved
EthanolStiripentol may increase the sedative activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Stiripentol.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Stiripentol.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Stiripentol.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Stiripentol.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Stiripentol.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Ethyl chloride is combined with Stiripentol.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Stiripentol.Approved, Illicit
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Stiripentol.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Stiripentol.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Stiripentol.Withdrawn
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Stiripentol.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Stiripentol.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Stiripentol.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Stiripentol is combined with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Stiripentol.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Stiripentol.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Stiripentol.Illicit, Vet Approved
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Stiripentol.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Stiripentol.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Stiripentol.Approved, Investigational
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Stiripentol.Approved
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Stiripentol.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Stiripentol.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Stiripentol.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Stiripentol.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Stiripentol.Approved, Illicit, Withdrawn
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Stiripentol.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Stiripentol.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Stiripentol.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Stiripentol.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Stiripentol.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Stiripentol.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Stiripentol.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Fluanisone is combined with Stiripentol.Experimental
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Stiripentol.Investigational
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Stiripentol.Approved, Illicit
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Stiripentol.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Stiripentol.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Stiripentol.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Stiripentol.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Stiripentol.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Stiripentol.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Stiripentol.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Stiripentol.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Stiripentol.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Stiripentol.Approved, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Stiripentol.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Stiripentol.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Stiripentol.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Stiripentol.Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Stiripentol.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Stiripentol.Approved
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Stiripentol.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Stiripentol.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Stiripentol.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Stiripentol.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Stiripentol.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Stiripentol.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Stiripentol.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Stiripentol.Approved
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Stiripentol.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Stiripentol.Approved, Illicit
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Stiripentol.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Stiripentol.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Stiripentol.Approved
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Stiripentol.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Stiripentol.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Stiripentol.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Stiripentol.Approved
GepironeThe risk or severity of adverse effects can be increased when Gepirone is combined with Stiripentol.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Stiripentol.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Stiripentol.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Stiripentol.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Stiripentol.Approved, Illicit
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Stiripentol.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Stiripentol.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Stiripentol.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Stiripentol.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Stiripentol.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Stiripentol.Approved, Illicit, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Stiripentol.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Stiripentol.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Stiripentol.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Stiripentol.Investigational
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Stiripentol.Approved, Illicit
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Stiripentol.Approved
HistamineThe serum concentration of Histamine can be increased when it is combined with Stiripentol.Approved, Investigational
HydrocodoneStiripentol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Stiripentol.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Stiripentol.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Stiripentol.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Stiripentol.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Stiripentol.Approved
IcotinibThe serum concentration of Icotinib can be increased when it is combined with Stiripentol.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Stiripentol.Approved
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Stiripentol.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Stiripentol.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Stiripentol.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Stiripentol.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Stiripentol.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Stiripentol.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Stiripentol.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Stiripentol.Approved
IndalpineThe risk or severity of adverse effects can be increased when Stiripentol is combined with Indalpine.Investigational, Withdrawn
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Stiripentol.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Stiripentol.Approved
IndiplonThe risk or severity of adverse effects can be increased when Indiplon is combined with Stiripentol.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Stiripentol.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Stiripentol.Approved
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Stiripentol.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Stiripentol.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Stiripentol.Approved, Vet Approved
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Stiripentol.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Stiripentol.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Stiripentol.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Stiripentol.Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Stiripentol.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Stiripentol.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Stiripentol.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Stiripentol.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Stiripentol.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Stiripentol.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Stiripentol.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Stiripentol.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Stiripentol.Approved
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Stiripentol.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Stiripentol.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Stiripentol.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Stiripentol.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Stiripentol.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Stiripentol.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Stiripentol.Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Stiripentol.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Stiripentol.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Stiripentol.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Stiripentol.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Stiripentol.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Stiripentol is combined with Levocabastine.Approved
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Stiripentol.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Stiripentol.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Stiripentol.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Stiripentol.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Stiripentol.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Stiripentol.Approved
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Stiripentol.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Stiripentol.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Stiripentol.Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Stiripentol.Approved
LobeglitazoneThe metabolism of Stiripentol can be decreased when combined with Lobeglitazone.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Stiripentol.Illicit
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Stiripentol.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Stiripentol.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Stiripentol.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Stiripentol.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Stiripentol.Experimental
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Stiripentol.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Stiripentol.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Stiripentol.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Lormetazepam is combined with Stiripentol.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Stiripentol.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Stiripentol.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Stiripentol.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Stiripentol.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Stiripentol.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Stiripentol.Approved
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Stiripentol.Illicit, Withdrawn
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Stiripentol.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved, Vet Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Stiripentol.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Stiripentol.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Stiripentol.Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Stiripentol.Approved, Vet Approved
MebicarThe risk or severity of adverse effects can be increased when Mebicar is combined with Stiripentol.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Stiripentol.Approved
MedazepamThe risk or severity of adverse effects can be increased when Medazepam is combined with Stiripentol.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Stiripentol.Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Stiripentol.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Stiripentol.Approved
MefloquineThe therapeutic efficacy of Stiripentol can be decreased when used in combination with Mefloquine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Stiripentol.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Stiripentol.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Stiripentol.Approved, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Stiripentol.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Stiripentol.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Stiripentol.Approved, Vet Approved
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Stiripentol.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Stiripentol.Experimental
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Stiripentol.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Stiripentol.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Stiripentol.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Stiripentol.Experimental
MethadoneThe serum concentration of Methadone can be increased when it is combined with Stiripentol.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Stiripentol.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Stiripentol.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Stiripentol.Withdrawn
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Stiripentol.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Stiripentol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Stiripentol.Approved
MethotrimeprazineStiripentol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Stiripentol.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Stiripentol.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Stiripentol.Approved
Methyl salicylateThe serum concentration of Methyl salicylate can be increased when it is combined with Stiripentol.Approved, Vet Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Stiripentol.Experimental
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Stiripentol.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Stiripentol.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Stiripentol.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Stiripentol.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Stiripentol.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Stiripentol.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Stiripentol.Approved
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Stiripentol.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Stiripentol.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Stiripentol.Approved
MetyrosineStiripentol may increase the sedative activities of Metyrosine.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Stiripentol.Experimental
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Stiripentol.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Stiripentol.Approved
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Stiripentol.Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Stiripentol.Approved, Illicit
MidostaurinThe serum concentration of Midostaurin can be increased when it is combined with Stiripentol.Approved
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Stiripentol.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Stiripentol is combined with Milnacipran.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Stiripentol.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Stiripentol.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Stiripentol.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Stiripentol.Approved
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Stiripentol.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Stiripentol.Approved
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Stiripentol.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Stiripentol.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Stiripentol.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Stiripentol.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Stiripentol.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Stiripentol.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Stiripentol.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Stiripentol.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Stiripentol.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Stiripentol.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Stiripentol.Approved
NeratinibThe serum concentration of Neratinib can be increased when it is combined with Stiripentol.Approved, Investigational
NetupitantThe metabolism of Netupitant can be decreased when combined with Stiripentol.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Stiripentol.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Stiripentol.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Stiripentol.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Stiripentol.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Stiripentol.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Stiripentol.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Stiripentol.Approved
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Stiripentol.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Stiripentol.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Stiripentol.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Stiripentol.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Stiripentol.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Stiripentol.Approved, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Stiripentol.Approved, Vet Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Stiripentol.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Norflurane is combined with Stiripentol.Investigational
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Stiripentol.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Stiripentol.Approved, Illicit
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Stiripentol.Approved
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Stiripentol.Investigational
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Stiripentol.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Stiripentol.Approved
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be increased when it is combined with Stiripentol.Investigational
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Stiripentol.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Stiripentol.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Stiripentol.Approved, Illicit
OrlistatThe serum concentration of Stiripentol can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Stiripentol.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Stiripentol.Investigational
OsimertinibThe serum concentration of Stiripentol can be decreased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Stiripentol.Approved
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Stiripentol.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Oxethazaine is combined with Stiripentol.Investigational
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Stiripentol.Approved
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Stiripentol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Stiripentol.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Stiripentol.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Stiripentol.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Stiripentol.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Stiripentol.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Stiripentol.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Stiripentol.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Stiripentol.Approved
ParaldehydeStiripentol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Stiripentol.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Stiripentol.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Stiripentol.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Stiripentol.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Stiripentol.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Stiripentol.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Stiripentol.Approved
Peginterferon alfa-2bThe serum concentration of Stiripentol can be increased when it is combined with Peginterferon alfa-2b.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Penfluridol is combined with Stiripentol.Experimental
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Stiripentol.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Stiripentol.Approved, Vet Approved
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Stiripentol.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
PerazineThe risk or severity of adverse effects can be increased when Perazine is combined with Stiripentol.Investigational
PergolideThe serum concentration of Pergolide can be increased when it is combined with Stiripentol.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Stiripentol.Approved
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Stiripentol.Approved, Investigational
PerospironeThe serum concentration of Perospirone can be increased when it is combined with Stiripentol.Approved
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Stiripentol.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Stiripentol.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Stiripentol.Withdrawn
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Stiripentol.Experimental
PhenforminThe metabolism of Phenformin can be decreased when combined with Stiripentol.Approved, Withdrawn
PhenibutThe risk or severity of adverse effects can be increased when Phenibut is combined with Stiripentol.Experimental
PhenobarbitalThe serum concentration of Stiripentol can be decreased when it is combined with Phenobarbital.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Stiripentol.Experimental
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Stiripentol.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Stiripentol.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Stiripentol.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Stiripentol.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Stiripentol.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Stiripentol.Approved, Investigational
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Stiripentol.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Stiripentol.Approved
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Stiripentol.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Stiripentol.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Stiripentol.Approved, Vet Approved
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Stiripentol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Stiripentol.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Stiripentol.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Stiripentol.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Stiripentol.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Stiripentol.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
PramipexoleStiripentol may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Stiripentol.Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Stiripentol.Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Stiripentol.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be increased when it is combined with Stiripentol.Investigational
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Stiripentol.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Stiripentol.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Stiripentol.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Stiripentol.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Stiripentol.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Stiripentol.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Stiripentol.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Stiripentol.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Stiripentol.Experimental
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Stiripentol.Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Stiripentol.Approved
PrimidoneThe metabolism of Primidone can be decreased when combined with Stiripentol.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Stiripentol.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Stiripentol.Approved, Investigational, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Stiripentol.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Stiripentol.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Stiripentol.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Stiripentol.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Stiripentol.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Stiripentol.Approved
PropanididThe risk or severity of adverse effects can be increased when Propanidid is combined with Stiripentol.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Stiripentol.Approved, Vet Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Stiripentol.Approved
Propoxyphene napsylateThe serum concentration of Propoxyphene napsylate can be increased when it is combined with Stiripentol.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Stiripentol.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Stiripentol.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Proxibarbal is combined with Stiripentol.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Stiripentol.Investigational
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Stiripentol.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Stiripentol.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Stiripentol.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Stiripentol.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Stiripentol.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Stiripentol.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Stiripentol.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Quinisocaine is combined with Stiripentol.Experimental
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Stiripentol.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Raclopride is combined with Stiripentol.Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Stiripentol.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Stiripentol.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Stiripentol.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Stiripentol.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Stiripentol.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Stiripentol.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Stiripentol.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Stiripentol.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Stiripentol.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Stiripentol.Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Stiripentol.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Stiripentol.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Stiripentol.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Stiripentol.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Stiripentol.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Stiripentol.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Stiripentol.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Stiripentol.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Stiripentol.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Ritanserin is combined with Stiripentol.Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Stiripentol.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Stiripentol.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Stiripentol.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Stiripentol.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Stiripentol.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Stiripentol.Vet Approved
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Stiripentol.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Stiripentol.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Stiripentol.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Stiripentol.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Stiripentol.Approved, Withdrawn
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Stiripentol.Approved, Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Stiripentol.Approved
RupatadineThe serum concentration of Rupatadine can be increased when it is combined with Stiripentol.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Stiripentol.Approved
SafinamideThe serum concentration of Safinamide can be increased when it is combined with Stiripentol.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Stiripentol.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Stiripentol.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Stiripentol.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Stiripentol.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Stiripentol.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Stiripentol.Approved
SepranoloneThe risk or severity of adverse effects can be increased when Sepranolone is combined with Stiripentol.Investigational
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Stiripentol.Approved
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Stiripentol.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Stiripentol.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Stiripentol.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Stiripentol.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Stiripentol.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Stiripentol.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Stiripentol.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Stiripentol.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Stiripentol.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Stiripentol.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Stiripentol.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Stiripentol.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Stiripentol.Experimental
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Stiripentol.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Stiripentol.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Stiripentol.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Stiripentol.Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Stiripentol.Approved
SultoprideThe risk or severity of adverse effects can be increased when Sultopride is combined with Stiripentol.Experimental
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Stiripentol.Approved, Investigational
SuvorexantStiripentol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Stiripentol.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Stiripentol.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Stiripentol.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Stiripentol.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Stiripentol.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Stiripentol.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Tandospirone is combined with Stiripentol.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Stiripentol.Approved
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Stiripentol.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Stiripentol.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Stiripentol.Investigational, Withdrawn
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Stiripentol.Withdrawn
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Stiripentol.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Stiripentol.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Stiripentol.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Stiripentol.Approved
Tenofovir disoproxilThe metabolism of Stiripentol can be decreased when combined with Tenofovir disoproxil.Approved, Investigational
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Stiripentol.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Stiripentol.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Stiripentol.Experimental
TeriflunomideThe serum concentration of Stiripentol can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Stiripentol.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Stiripentol.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Stiripentol.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Stiripentol.Approved, Vet Approved
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Stiripentol.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Stiripentol.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Stiripentol.Investigational
ThalidomideStiripentol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Stiripentol.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Stiripentol.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Stiripentol.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Stiripentol.Withdrawn
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Stiripentol.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Stiripentol.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Stiripentol.Approved
TiaprideThe risk or severity of adverse effects can be increased when Tiapride is combined with Stiripentol.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Stiripentol.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Stiripentol.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Stiripentol.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Stiripentol.Experimental
TimololThe metabolism of Timolol can be decreased when combined with Stiripentol.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Stiripentol.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Stiripentol.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Stiripentol.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Stiripentol.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Stiripentol.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Stiripentol.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Stiripentol.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Stiripentol.Approved, Withdrawn
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Stiripentol.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Stiripentol.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Stiripentol.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Stiripentol.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Stiripentol.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Stiripentol.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Stiripentol.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Stiripentol.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Stiripentol.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Stiripentol.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Stiripentol.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Stiripentol.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Stiripentol.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Tricaine methanesulfonate is combined with Stiripentol.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Trichloroethylene is combined with Stiripentol.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Stiripentol.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Trifluperidol is combined with Stiripentol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Stiripentol.Approved, Vet Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Stiripentol.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Stiripentol.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Stiripentol.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Stiripentol.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Stiripentol.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Stiripentol.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Stiripentol.Experimental
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Stiripentol.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Stiripentol.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Stiripentol.Approved
ValbenazineThe serum concentration of Valbenazine can be increased when it is combined with Stiripentol.Approved, Investigational
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Stiripentol.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Stiripentol.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Stiripentol.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Stiripentol.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Stiripentol.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Stiripentol.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Stiripentol.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Stiripentol.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Stiripentol.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Veralipride is combined with Stiripentol.Experimental
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Stiripentol.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Stiripentol.Approved, Investigational
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Stiripentol.Investigational
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Stiripentol.Approved
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Stiripentol.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Stiripentol.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Stiripentol.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Stiripentol.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Stiripentol.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Stiripentol.Approved, Investigational
Vinyl etherThe risk or severity of adverse effects can be increased when Vinyl ether is combined with Stiripentol.Experimental
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Stiripentol.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Stiripentol.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Stiripentol.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Stiripentol.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Stiripentol.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Stiripentol.Approved
XenonThe risk or severity of adverse effects can be increased when Xenon is combined with Stiripentol.Experimental
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Stiripentol.Vet Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Stiripentol.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Stiripentol.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Stiripentol.Approved
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Stiripentol.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Stiripentol.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Stiripentol.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Stiripentol.Approved, Investigational, Withdrawn
ZimelidineThe risk or severity of adverse effects can be increased when Stiripentol is combined with Zimelidine.Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Stiripentol.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Stiripentol.Vet Approved
ZolpidemStiripentol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Stiripentol.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Stiripentol.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Stiripentol.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Stiripentol.Approved
ZucapsaicinThe metabolism of Stiripentol can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Stiripentol.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Quilichini PP, Chiron C, Ben-Ari Y, Gozlan H: Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16. [PubMed:16650136]
  2. Trojnar MK, Wojtal K, Trojnar MP, Czuczwar SJ: Stiripentol. A novel antiepileptic drug. Pharmacol Rep. 2005 Mar-Apr;57(2):154-60. [PubMed:15886413]
  3. Sada N, Lee S, Katsu T, Otsuki T, Inoue T: Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science. 2015 Mar 20;347(6228):1362-7. doi: 10.1126/science.aaa1299. [PubMed:25792327]
  4. Grosenbaugh DK, Mott DD: Stiripentol in refractory status epilepticus. Epilepsia. 2013 Sep;54 Suppl 6:103-5. doi: 10.1111/epi.12291. [PubMed:24001087]
  5. European Medicines Agency (EMA): DIACOMIT Summary of Product Characteristics [Link]
External Links
PubChem Compound
5311454
PubChem Substance
310265035
ChemSpider
4470940
ChEMBL
CHEMBL1983350
ATC Codes
N03AX17 — Stiripentol
AHFS Codes
  • 28:12.92 — Miscellaneous Anticonvulsants
MSDS
Download (56.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4No Longer AvailableNot AvailableDravet Syndrome1
4RecruitingTreatmentEpilepsies1
Not AvailableAvailableNot AvailableDravet Syndrome2
Not AvailableAvailableNot AvailableDravet Syndrome / Epileptic Encephalopathies Associated With SCN1A Mutations1
Not AvailableRecruitingNot AvailableEpilepsies1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral250 mg
CapsuleOral500 mg
Powder, for suspensionOral250 mg
Powder, for suspensionOral500 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)64MSDS
boiling point (°C)365.4MSDS
water solubilityInsoluble Trojnar MK, Wojtal K, Trojnar MP, Czuczwar SJ, 2005.
logP3.53MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.405 mg/mLALOGPS
logP3.01ALOGPS
logP3.12ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)14.34ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area38.69 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity66.77 m3·mol-1ChemAxon
Polarizability26.21 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzodioxoles
Sub Class
Not Available
Direct Parent
Benzodioxoles
Alternative Parents
Styrenes / Secondary alcohols / Oxacyclic compounds / Acetals / Hydrocarbon derivatives
Substituents
Benzodioxole / Styrene / Benzenoid / Secondary alcohol / Oxacycle / Acetal / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Alcohol
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Agonist
Positive allosteric modulator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...

Components:
References
  1. Fisher JL: The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator. Neuropharmacology. 2009 Jan;56(1):190-7. doi: 10.1016/j.neuropharm.2008.06.004. Epub 2008 Jun 10. [PubMed:18585399]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Nad binding
Specific Function
Not Available
Gene Name
LDHA
Uniprot ID
P00338
Uniprot Name
L-lactate dehydrogenase A chain
Molecular Weight
36688.465 Da
References
  1. Sada N, Lee S, Katsu T, Otsuki T, Inoue T: Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science. 2015 Mar 20;347(6228):1362-7. doi: 10.1126/science.aaa1299. [PubMed:25792327]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Nad binding
Specific Function
Not Available
Gene Name
LDHB
Uniprot ID
P07195
Uniprot Name
L-lactate dehydrogenase B chain
Molecular Weight
36638.225 Da
References
  1. Sada N, Lee S, Katsu T, Otsuki T, Inoue T: Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science. 2015 Mar 20;347(6228):1362-7. doi: 10.1126/science.aaa1299. [PubMed:25792327]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. European Medicines Agency (EMA): DIACOMIT Summary of Product Characteristics [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. European Medicines Agency (EMA): DIACOMIT Summary of Product Characteristics [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. European Medicines Agency (EMA): DIACOMIT Summary of Product Characteristics [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. European Medicines Agency (EMA): DIACOMIT Summary of Product Characteristics [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Trojnar MK, Wojtal K, Trojnar MP, Czuczwar SJ: Stiripentol. A novel antiepileptic drug. Pharmacol Rep. 2005 Mar-Apr;57(2):154-60. [PubMed:15886413]

Drug created on September 22, 2015 13:59 / Updated on October 21, 2017 19:33