Magnesium sulfate

Identification

Name
Magnesium sulfate
Accession Number
DB00653  (APRD01080)
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Structure
Thumb
Synonyms
  • Magnesium sulfate (1:1)
  • Magnesium sulfate anhydrous
  • Magnesium sulphate
  • magnesium(II) sulfate
  • Magnesiumsulfat
  • MgSO4
Product Ingredients
IngredientUNIICASInChI Key
Magnesium sulfate heptahydrateSK47B8698T10034-99-8WRUGWIBCXHJTDG-UHFFFAOYSA-L
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
50% Magnesium Sulfate Injection USPSolution500 mgIntramuscular; IntravenousHospira, Inc.1975-12-31Not applicableCanada
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2015-09-16Not applicableUs
Magnesium SulfateInjection, solution4 g/100mLIntravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousMedical Purchasing Solutions, Llc2000-08-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousFresenius Kabi2016-01-29Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousFresenius Kabi2000-08-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousCardinal Health2000-08-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2017-01-13Not applicableUs
Magnesium SulfateInjection, solution4 g/50mLIntravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium SulfateInjection, solution4 g/100mLIntravenousA S Medication Solutions1994-06-242017-06-20Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Magnesium SulfateInjection40 g/1000mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousX Gen Pharmaceuticals, Inc.2014-02-23Not applicableUs
Magnesium SulfateInjection1 g/100mLIntravenousWG Critical Care, LLC2016-03-08Not applicableUs
Magnesium SulfateInjection2 g/50mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousExela Pharma Sciences, Llc.2014-02-23Not applicableUs
Magnesium SulfateInjection, solution80 mg/mLIntravenousFresenius Kabi Norge As2017-08-01Not applicableUs
Magnesium SulfateInjection, solution80 mg/mLIntravenousFresenius Kabi2016-03-15Not applicableUs
Magnesium SulfateInjection20 g/500mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousPhysicians Total Care, Inc.2006-12-12Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Assured Epsom SaltGranule100 g/100gOralHefei Yatai Daily Chemical Products Co., Ltd.2016-03-30Not applicableUs
Assured Epsom SaltGranule100 g/100gOralGreenbrier International, Inc.2016-06-14Not applicableUs
EpsalOintment400 mg/gTopicalPress Chemical And Pharmaceutical Laboratories1957-01-15Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalVi Jon1998-07-15Not applicableUs
Epsom SaltGranule100 kg/100kgOralWestern Family1998-06-05Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalPublix Supermarkets, Inc.2014-09-05Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalWinco Foods2015-05-21Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalSupervalu2005-03-21Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalTopco Associates1999-07-15Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalMeijer Distribution2015-07-21Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium Lactate Et Magnesium SulfateMagnesium sulfate (65 mg) + Calcium lactate (260 mg)TabletOralBio Vita1987-12-312005-07-20Canada
ColPrep KitMagnesium sulfate (1.6 g/22.7g) + Potassium sulfate (3.13 g/22.7g) + Sodium sulfate (17.5 g/22.7g)Powder, for solutionOralKvk Tech,Inc2016-12-27Not applicableUs
Eau Purgative RigaMagnesium sulfate (2.4 g) + Sodium sulfate (1.056 g)LiquidOralGlendale Agencies1978-12-311996-11-29Canada
Elliotts BMagnesium sulfate (3 mg/10mL) + Calcium Chloride (2 mg/10mL) + D-glucose (8 mg/10mL) + Potassium Chloride (3 mg/10mL) + Sodium Chloride (73 mg/10mL) + Sodium bicarbonate (19 mg/10mL) + Sodium phosphate, monobasic (2 mg/10mL)InjectionIntrathecalQOL Medical, LLC.2006-09-27Not applicableUs
Elliotts BMagnesium sulfate (3 mg/10mL) + Calcium Chloride (2 mg/10mL) + D-glucose (8 mg/10mL) + Potassium Chloride (3 mg/10mL) + Sodium Chloride (73 mg/10mL) + Sodium bicarbonate (19 mg/10mL) + Sodium phosphate, monobasic (2 mg/10mL)InjectionIntrathecalLukare Medical, Llc2013-06-04Not applicableUs
Formule 1705 - LiqMagnesium sulfate (250 mg) + Ox bile extract (1.56 mg)LiquidOralBio Vita1993-12-312003-07-16Canada
KabivenMagnesium sulfate heptahydrate (96 mg/100mL) + Calcium Chloride (29 mg/100mL) + D-glucose monohydrate (9.8 g/100mL) + Glutamic Acid (164 mg/100mL) + Glycine (231 mg/100mL) + Histidine (199 mg/100mL) + L-Alanine (467 mg/100mL) + L-Arginine (330 mg/100mL) + L-Aspartic Acid (99 mg/100mL) + L-Isoleucine (164 mg/100mL) + L-Leucine (231 mg/100mL) + L-Lysine hydrochloride (263 mg/100mL) + L-Phenylalanine (231 mg/100mL) + L-Proline (199 mg/100mL) + L-Threonine (164 mg/100mL) + L-Tryptophan (55 mg/100mL) + L-Tyrosine (6.7 mg/100mL) + L-Valine (213 mg/100mL) + Methionine (164 mg/100mL) + Potassium Chloride (174 mg/100mL) + Serine (131 mg/100mL) + Sodium acetate (239 mg/100mL) + Sodium glycerophosphate (147 mg/100mL) + Soybean oil (3.9 g/100mL)Injection, emulsionIntravenousFresenius Kabi2014-08-25Not applicableUs
Magnesium CapMagnesium sulfate (111 mg) + Magnesium oxide (82 mg)CapsuleOralAlsi Cie Ltee1983-12-312002-06-12Canada
Magnesium Sulfate In 5% Dextrose Inj(20mg/ml)Magnesium sulfate (20 mg) + Dextrose, unspecified form (50 mg)SolutionIntravenousHospira, Inc.1996-12-30Not applicableCanada
Multiple Electrolyte Additive InjMagnesium sulfate (19.8 mg) + Calcium gluconate (20.6 mg) + Potassium Chloride (29.8 mg) + Sodium Chloride (46.6 mg)LiquidIntravenousInternational Medication Systems, Limited1980-12-311997-08-15Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CentratexMagnesium sulfate (6.9 mg/1) + Cupric sulfate (.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic Acid (1 mg/1) + Iron (106 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate (18.2 mg/1)CapsuleOralCenturion Labs2009-06-14Not applicableUs
Concept DHAMagnesium sulfate (5 mg/1) + Ascorbic acid (25 mg/1) + Biotin (300 ug/1) + Cupric sulfate (2 mg/1) + Cyanocobalamin (12.5 ug/1) + Folic Acid (1 mg/1) + Iron (53.5 mg/1) + Iron (38 mg/1) + Niacin (1.8 mg/1) + Omega-3-acid ethyl esters (200 mg/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc sulfate (10 mg/1)Capsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBMagnesium sulfate (6.9 mg/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cupric sulfate (800 ug/1) + Cyanocobalamin (10 ug/1) + Folic Acid (1 mg/1) + Iron (130 mg/1) + Iron (92.4 mg/1) + Manganese sulfate (1.3 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate (18.2 mg/1)CapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate heptahydrate (.5 g/mL)Injection, solutionIntramuscular; IntravenousGeneral Injectables & Vaccines2010-08-012017-01-28Us
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousCardinal Health2000-08-082017-07-19Us
Magnesium SulfateMagnesium sulfate (20 g/250mL)Injection, solutionIntravenousCantrell Drug Company2011-07-25Not applicableUs
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate (20 g/500mL)Injection, solutionIntravenousCantrell Drug Company2011-02-21Not applicableUs
Categories
UNII
ML30MJ2U7I
CAS number
7487-88-9
Weight
Average: 120.368
Monoisotopic: 119.936771076
Chemical Formula
MgO4S
InChI Key
CSNNHWWHGAXBCP-UHFFFAOYSA-L
InChI
InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
IUPAC Name
magnesium(2+) ion sulfate
SMILES
[Mg++].[O-]S([O-])(=O)=O

Pharmacology

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.

Associated Conditions
Associated Therapies
Pharmacodynamics

Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.

Mechanism of action

Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Magnesium sulfate reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. Additionally, Magnesium inhibits Ca2+ influx through dihydropyridine-sensitive, voltage-dependent channels. This accounts for much of its relaxant action on vascular smooth muscle.

TargetActionsOrganism
UVoltage-dependent calcium channel gamma-1 subunitNot AvailableHuman
UVoltage-dependent calcium channel subunit alpha-2/delta-1Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit alpha-1CNot AvailableHuman
UVoltage-dependent L-type calcium channel subunit beta-1Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit beta-2Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit alpha-1SNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding

25-30%

Metabolism

None

Route of elimination

Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.

Half life

43.2 hours (for newborns)

Clearance
Not Available
Toxicity

LD50 = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe therapeutic efficacy of 2-HYDROXY-1,4-NAPHTHOQUINONE can be increased when used in combination with Magnesium sulfate.Experimental
2-mercaptobenzothiazoleThe therapeutic efficacy of 2-mercaptobenzothiazole can be increased when used in combination with Magnesium sulfate.Vet Approved
7-NitroindazoleThe therapeutic efficacy of 7-Nitroindazole can be increased when used in combination with Magnesium sulfate.Experimental
AcepromazineThe therapeutic efficacy of Acepromazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
AceprometazineThe therapeutic efficacy of Aceprometazine can be increased when used in combination with Magnesium sulfate.Approved
AdipiplonThe therapeutic efficacy of Adipiplon can be increased when used in combination with Magnesium sulfate.Investigational
AgmatineThe risk or severity of hypotension and neuromuscular blockade can be increased when Agmatine is combined with Magnesium sulfate.Experimental, Investigational
AgomelatineThe therapeutic efficacy of Agomelatine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Alaproclate.Experimental
AlcuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Alcuronium.Experimental
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Magnesium sulfate.Approved
AlfacalcidolThe serum concentration of Magnesium sulfate can be increased when it is combined with Alfacalcidol.Approved, Nutraceutical
AlfaxaloneThe therapeutic efficacy of Alfaxalone can be increased when used in combination with Magnesium sulfate.Vet Approved
AlfentanilThe therapeutic efficacy of Alfentanil can be increased when used in combination with Magnesium sulfate.Approved, Illicit
AlfuzosinThe risk or severity of hypotension can be increased when Alfuzosin is combined with Magnesium sulfate.Approved, Investigational
AllopregnanoloneThe therapeutic efficacy of Allopregnanolone can be increased when used in combination with Magnesium sulfate.Investigational
AlphacetylmethadolThe therapeutic efficacy of Alphacetylmethadol can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
AlphaprodineThe therapeutic efficacy of Alphaprodine can be increased when used in combination with Magnesium sulfate.Illicit
AlprazolamThe therapeutic efficacy of Alprazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
AmiodaroneThe risk or severity of hypotension and neuromuscular blockade can be increased when Amiodarone is combined with Magnesium sulfate.Approved, Investigational
AmisulprideThe therapeutic efficacy of Amisulpride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmitriptylineThe therapeutic efficacy of Amitriptyline can be increased when used in combination with Magnesium sulfate.Approved
AmlodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Amlodipine is combined with Magnesium sulfate.Approved
AmobarbitalThe therapeutic efficacy of Amobarbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
AmorolfineThe therapeutic efficacy of Amorolfine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmoxapineThe therapeutic efficacy of Amoxapine can be increased when used in combination with Magnesium sulfate.Approved
AmperozideThe therapeutic efficacy of Amperozide can be increased when used in combination with Magnesium sulfate.Experimental
Amphotericin BThe therapeutic efficacy of Amphotericin B can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmrinoneThe risk or severity of hypotension and neuromuscular blockade can be increased when Amrinone is combined with Magnesium sulfate.Approved
AnidulafunginThe therapeutic efficacy of Anidulafungin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AranidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Aranidipine is combined with Magnesium sulfate.Approved, Investigational
AripiprazoleThe therapeutic efficacy of Aripiprazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ArotinololThe risk or severity of hypotension, conduction block, and bradycardia can be increased when Arotinolol is combined with Magnesium sulfate.Investigational
ArtemetherThe therapeutic efficacy of Artemether can be increased when used in combination with Magnesium sulfate.Approved
ArticaineThe therapeutic efficacy of Articaine can be increased when used in combination with Magnesium sulfate.Approved
AsenapineThe therapeutic efficacy of Asenapine can be increased when used in combination with Magnesium sulfate.Approved
AtracuriumMagnesium sulfate may increase the neuromuscular blocking activities of Atracurium.Approved, Experimental, Investigational
Atracurium besylateMagnesium sulfate may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzaperoneThe therapeutic efficacy of Azaperone can be increased when used in combination with Magnesium sulfate.Investigational, Vet Approved
AzelastineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Azelnidipine is combined with Magnesium sulfate.Approved, Investigational
AzimilideThe risk or severity of hypotension and neuromuscular blockade can be increased when Azimilide is combined with Magnesium sulfate.Investigational
BaclofenThe therapeutic efficacy of Baclofen can be increased when used in combination with Magnesium sulfate.Approved
Bafilomycin A1The therapeutic efficacy of Bafilomycin A1 can be increased when used in combination with Magnesium sulfate.Experimental
BarbexacloneThe metabolism of Magnesium sulfate can be increased when combined with Barbexaclone.Experimental
BarbitalThe therapeutic efficacy of Barbital can be increased when used in combination with Magnesium sulfate.Illicit
BarnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Barnidipine is combined with Magnesium sulfate.Approved
BencyclaneThe risk or severity of hypotension and neuromuscular blockade can be increased when Bencyclane is combined with Magnesium sulfate.Experimental
BenidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Benidipine is combined with Magnesium sulfate.Approved, Investigational
BenperidolThe therapeutic efficacy of Benperidol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BenzocaineThe therapeutic efficacy of Benzocaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Benzyl alcoholThe therapeutic efficacy of Benzyl alcohol can be increased when used in combination with Magnesium sulfate.Approved
BepridilThe risk or severity of hypotension and neuromuscular blockade can be increased when Bepridil is combined with Magnesium sulfate.Approved, Withdrawn
BevantololThe risk or severity of hypotension can be increased when Bevantolol is combined with Magnesium sulfate.Approved
BifonazoleThe therapeutic efficacy of Bifonazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BioallethrinThe risk or severity of hypotension and neuromuscular blockade can be increased when Bioallethrin is combined with Magnesium sulfate.Approved, Experimental
Brefeldin AThe therapeutic efficacy of Brefeldin A can be increased when used in combination with Magnesium sulfate.Experimental
BrexpiprazoleThe therapeutic efficacy of Brexpiprazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
BromazepamThe therapeutic efficacy of Bromazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
BromisovalThe therapeutic efficacy of Bromisoval can be increased when used in combination with Magnesium sulfate.Experimental
BromperidolThe therapeutic efficacy of Bromperidol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrompheniramineThe therapeutic efficacy of Brompheniramine can be increased when used in combination with Magnesium sulfate.Approved
BrotizolamThe therapeutic efficacy of Brotizolam can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
BucindololThe risk or severity of hypotension can be increased when Bucindolol is combined with Magnesium sulfate.Investigational
BunazosinThe risk or severity of hypotension can be increased when Bunazosin is combined with Magnesium sulfate.Investigational
BupivacaineThe therapeutic efficacy of Bupivacaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BuprenorphineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe therapeutic efficacy of Buspirone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ButabarbitalThe therapeutic efficacy of Butabarbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButacaineThe therapeutic efficacy of Butacaine can be increased when used in combination with Magnesium sulfate.Vet Approved
ButalbitalThe therapeutic efficacy of Butalbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButambenThe therapeutic efficacy of Butamben can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
ButenafineThe therapeutic efficacy of Butenafine can be increased when used in combination with Magnesium sulfate.Approved
ButethalThe therapeutic efficacy of Butethal can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButoconazoleThe therapeutic efficacy of Butoconazole can be increased when used in combination with Magnesium sulfate.Approved
ButorphanolThe therapeutic efficacy of Butorphanol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Vet Approved
CalcitriolThe serum concentration of Magnesium sulfate can be increased when it is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Acetate.Approved, Investigational
Calcium CarbonateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Carbonate.Approved, Investigational
Calcium ChlorideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium lactate.Approved, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium levulinateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium levulinate.Approved, Experimental
Calcium pangamateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Phosphate.Approved
CandicidinThe therapeutic efficacy of Candicidin can be increased when used in combination with Magnesium sulfate.Withdrawn
CanertinibThe therapeutic efficacy of Canertinib can be increased when used in combination with Magnesium sulfate.Investigational
Capric acidThe therapeutic efficacy of Capric acid can be increased when used in combination with Magnesium sulfate.Experimental
CarbamazepineThe therapeutic efficacy of Carbamazepine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CarbinoxamineThe therapeutic efficacy of Carbinoxamine can be increased when used in combination with Magnesium sulfate.Approved
CarboxyamidotriazoleThe risk or severity of hypotension and neuromuscular blockade can be increased when Carboxyamidotriazole is combined with Magnesium sulfate.Investigational
CarfentanilThe therapeutic efficacy of Carfentanil can be increased when used in combination with Magnesium sulfate.Illicit, Investigational, Vet Approved
CarisoprodolThe therapeutic efficacy of Carisoprodol can be increased when used in combination with Magnesium sulfate.Approved
CaroverineThe risk or severity of hypotension and neuromuscular blockade can be increased when Caroverine is combined with Magnesium sulfate.Experimental
CarvedilolThe risk or severity of hypotension can be increased when Carvedilol is combined with Magnesium sulfate.Approved, Investigational
CaseinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Casein.Approved
CaspofunginThe therapeutic efficacy of Caspofungin can be increased when used in combination with Magnesium sulfate.Approved
CeruleninThe therapeutic efficacy of Cerulenin can be increased when used in combination with Magnesium sulfate.Approved
CetirizineThe therapeutic efficacy of Cetirizine can be increased when used in combination with Magnesium sulfate.Approved
Chloral hydrateThe therapeutic efficacy of Chloral hydrate can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe therapeutic efficacy of Chlordiazepoxide can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
ChlormezanoneThe therapeutic efficacy of Chlormezanone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ChloroprocaineThe therapeutic efficacy of Chloroprocaine can be increased when used in combination with Magnesium sulfate.Approved
ChloroxineThe therapeutic efficacy of Chloroxine can be increased when used in combination with Magnesium sulfate.Approved
ChlorphenamineThe therapeutic efficacy of Chlorphenamine can be increased when used in combination with Magnesium sulfate.Approved
ChlorpromazineThe therapeutic efficacy of Chlorpromazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ChlorprothixeneThe therapeutic efficacy of Chlorprothixene can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ChlortetracyclineMagnesium sulfate can cause a decrease in the absorption of Chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
ChlorzoxazoneThe therapeutic efficacy of Chlorzoxazone can be increased when used in combination with Magnesium sulfate.Approved
CiclopiroxThe therapeutic efficacy of Ciclopirox can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CilnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Cilnidipine is combined with Magnesium sulfate.Approved, Investigational
CimetidineThe serum concentration of Magnesium sulfate can be increased when it is combined with Cimetidine.Approved, Investigational
CinchocaineThe therapeutic efficacy of Cinchocaine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
CinnarizineThe risk or severity of hypotension and neuromuscular blockade can be increased when Cinnarizine is combined with Magnesium sulfate.Approved, Investigational
CinoxacinThe serum concentration of Cinoxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Withdrawn
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
CisatracuriumMagnesium sulfate may increase the neuromuscular blocking activities of Cisatracurium.Approved
CitalopramThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Citalopram.Approved
ClemastineThe therapeutic efficacy of Clemastine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ClevidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Clevidipine is combined with Magnesium sulfate.Approved, Investigational
ClidiniumThe therapeutic efficacy of Clidinium can be increased when used in combination with Magnesium sulfate.Approved
ClobazamThe therapeutic efficacy of Clobazam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
Clodronic AcidThe serum concentration of Clodronic Acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
clomethiazoleThe therapeutic efficacy of clomethiazole can be increased when used in combination with Magnesium sulfate.Investigational
ClomipramineThe therapeutic efficacy of Clomipramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ClonazepamThe therapeutic efficacy of Clonazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ClonidineThe therapeutic efficacy of Clonidine can be increased when used in combination with Magnesium sulfate.Approved
ClopenthixolThe therapeutic efficacy of Clopenthixol can be increased when used in combination with Magnesium sulfate.Experimental
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Magnesium sulfate.Approved
ClorazepateThe therapeutic efficacy of Clorazepate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ClothiapineThe therapeutic efficacy of Clothiapine can be increased when used in combination with Magnesium sulfate.Experimental
ClotrimazoleThe therapeutic efficacy of Clotrimazole can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ClozapineThe therapeutic efficacy of Clozapine can be increased when used in combination with Magnesium sulfate.Approved
CocaineThe therapeutic efficacy of Cocaine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
CordycepinThe therapeutic efficacy of Cordycepin can be increased when used in combination with Magnesium sulfate.Investigational
CyclandelateThe risk or severity of hypotension and neuromuscular blockade can be increased when Cyclandelate is combined with Magnesium sulfate.Approved
CyclizineThe therapeutic efficacy of Cyclizine can be increased when used in combination with Magnesium sulfate.Approved
CyclobenzaprineThe therapeutic efficacy of Cyclobenzaprine can be increased when used in combination with Magnesium sulfate.Approved
CyclopropaneThe therapeutic efficacy of Cyclopropane can be increased when used in combination with Magnesium sulfate.Experimental
CyclosporineThe therapeutic efficacy of Cyclosporine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
CyproheptadineThe therapeutic efficacy of Cyproheptadine can be increased when used in combination with Magnesium sulfate.Approved
DantroleneThe therapeutic efficacy of Dantrolene can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DapiprazoleThe therapeutic efficacy of Dapiprazole can be increased when used in combination with Magnesium sulfate.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Dapoxetine.Investigational
DarodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Darodipine is combined with Magnesium sulfate.Experimental
DecamethoniumMagnesium sulfate may increase the neuromuscular blocking activities of Decamethonium.Approved
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Magnesium sulfate.Approved
DemeclocyclineMagnesium sulfate can cause a decrease in the absorption of Demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DeramciclaneThe therapeutic efficacy of Deramciclane can be increased when used in combination with Magnesium sulfate.Investigational
DesfluraneThe therapeutic efficacy of Desflurane can be increased when used in combination with Magnesium sulfate.Approved
DesipramineThe therapeutic efficacy of Desipramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DesloratadineThe therapeutic efficacy of Desloratadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe therapeutic efficacy of Detomidine can be increased when used in combination with Magnesium sulfate.Vet Approved
DexbrompheniramineThe therapeutic efficacy of Dexbrompheniramine can be increased when used in combination with Magnesium sulfate.Approved
DexmedetomidineThe therapeutic efficacy of Dexmedetomidine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
DextroamphetamineThe risk or severity of hypotension can be increased when Dextroamphetamine is combined with Magnesium sulfate.Approved, Illicit
DextromoramideThe therapeutic efficacy of Dextromoramide can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DextropropoxypheneThe therapeutic efficacy of Dextropropoxyphene can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Withdrawn
DezocineThe therapeutic efficacy of Dezocine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DiazepamThe therapeutic efficacy of Diazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
DichloropheneThe therapeutic efficacy of Dichlorophene can be increased when used in combination with Magnesium sulfate.Vet Approved
Diethyl etherThe therapeutic efficacy of Diethyl ether can be increased when used in combination with Magnesium sulfate.Experimental
DifenoxinThe therapeutic efficacy of Difenoxin can be increased when used in combination with Magnesium sulfate.Approved, Illicit
DihydrocodeineThe therapeutic efficacy of Dihydrocodeine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
DihydroetorphineThe therapeutic efficacy of Dihydroetorphine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DihydromorphineThe therapeutic efficacy of Dihydromorphine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DiltiazemThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium sulfate.Approved, Investigational
DimenhydrinateThe therapeutic efficacy of Dimenhydrinate can be increased when used in combination with Magnesium sulfate.Approved
DiphenhydramineThe therapeutic efficacy of Diphenhydramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DiphenoxylateThe therapeutic efficacy of Diphenoxylate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
Dipotassium phosphateThe serum concentration of Dipotassium phosphate can be decreased when it is combined with Magnesium sulfate.Approved
DixyrazineThe therapeutic efficacy of Dixyrazine can be increased when used in combination with Magnesium sulfate.Experimental
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Magnesium sulfate.Approved
Domoic AcidMagnesium sulfate may increase the neuromuscular blocking activities of Domoic Acid.Experimental
DoramectinThe therapeutic efficacy of Doramectin can be increased when used in combination with Magnesium sulfate.Vet Approved
DotarizineThe risk or severity of hypotension and neuromuscular blockade can be increased when Dotarizine is combined with Magnesium sulfate.Investigational
DoxacuriumMagnesium sulfate may increase the neuromuscular blocking activities of Doxacurium chloride.Approved
DoxazosinThe risk or severity of hypotension can be increased when Doxazosin is combined with Magnesium sulfate.Approved
DoxepinThe therapeutic efficacy of Doxepin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DoxofyllineThe serum concentration of Doxofylline can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
DoxycyclineMagnesium sulfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Vet Approved
DPDPEThe therapeutic efficacy of DPDPE can be increased when used in combination with Magnesium sulfate.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Illicit
DronedaroneThe risk or severity of hypotension can be increased when Dronedarone is combined with Magnesium sulfate.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Vet Approved
DrotebanolThe therapeutic efficacy of Drotebanol can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Duloxetine.Approved
DyclonineThe therapeutic efficacy of Dyclonine can be increased when used in combination with Magnesium sulfate.Approved
EcgonineThe therapeutic efficacy of Ecgonine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
EconazoleThe therapeutic efficacy of Econazole can be increased when used in combination with Magnesium sulfate.Approved
EcopipamThe therapeutic efficacy of Ecopipam can be increased when used in combination with Magnesium sulfate.Investigational
EfavirenzThe serum concentration of Magnesium sulfate can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe therapeutic efficacy of Efinaconazole can be increased when used in combination with Magnesium sulfate.Approved
EfonidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Efonidipine is combined with Magnesium sulfate.Approved, Investigational
EltanoloneThe therapeutic efficacy of Eltanolone can be increased when used in combination with Magnesium sulfate.Investigational
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Magnesium sulfate.Approved
EnfluraneThe therapeutic efficacy of Enflurane can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
EnoxacinThe serum concentration of Enoxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
EntacaponeThe therapeutic efficacy of Entacapone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EperisoneThe risk or severity of hypotension and neuromuscular blockade can be increased when Eperisone is combined with Magnesium sulfate.Approved, Investigational
EpinephrineThe risk or severity of hypotension can be increased when Epinephrine is combined with Magnesium sulfate.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Escitalopram.Approved, Investigational
EstazolamThe therapeutic efficacy of Estazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
EszopicloneThe therapeutic efficacy of Eszopiclone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EthanolThe therapeutic efficacy of Ethanol can be increased when used in combination with Magnesium sulfate.Approved
EthchlorvynolThe therapeutic efficacy of Ethchlorvynol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
EthosuximideThe therapeutic efficacy of Ethosuximide can be increased when used in combination with Magnesium sulfate.Approved
EthotoinThe therapeutic efficacy of Ethotoin can be increased when used in combination with Magnesium sulfate.Approved
Ethyl carbamateThe therapeutic efficacy of Ethyl carbamate can be increased when used in combination with Magnesium sulfate.Withdrawn
Ethyl chlorideThe therapeutic efficacy of Ethyl chloride can be increased when used in combination with Magnesium sulfate.Approved, Experimental, Investigational
Ethyl loflazepateThe therapeutic efficacy of Ethyl loflazepate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
EthylmorphineThe therapeutic efficacy of Ethylmorphine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
EtidocaineThe therapeutic efficacy of Etidocaine can be increased when used in combination with Magnesium sulfate.Approved
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Magnesium sulfate.Approved
EtifoxineThe therapeutic efficacy of Etifoxine can be increased when used in combination with Magnesium sulfate.Investigational, Withdrawn
EtizolamThe therapeutic efficacy of Etizolam can be increased when used in combination with Magnesium sulfate.Approved
EtomidateThe therapeutic efficacy of Etomidate can be increased when used in combination with Magnesium sulfate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Etoperidone.Withdrawn
EtorphineThe therapeutic efficacy of Etorphine can be increased when used in combination with Magnesium sulfate.Illicit, Vet Approved
EzogabineThe therapeutic efficacy of Ezogabine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FelbamateThe therapeutic efficacy of Felbamate can be increased when used in combination with Magnesium sulfate.Approved
FelodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Felodipine is combined with Magnesium sulfate.Approved, Investigational
FencamfamineThe therapeutic efficacy of Fencamfamine can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
FendilineThe risk or severity of hypotension and neuromuscular blockade can be increased when Fendiline is combined with Magnesium sulfate.Withdrawn
FentanylThe therapeutic efficacy of Fentanyl can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
FenticonazoleThe therapeutic efficacy of Fenticonazole can be increased when used in combination with Magnesium sulfate.Experimental
FexofenadineThe therapeutic efficacy of Fexofenadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Fish oilThe risk or severity of hypotension and neuromuscular blockade can be increased when Fish oil is combined with Magnesium sulfate.Approved, Nutraceutical
FleroxacinThe serum concentration of Fleroxacin can be decreased when it is combined with Magnesium sulfate.Approved
FlibanserinThe therapeutic efficacy of Flibanserin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FluanisoneThe therapeutic efficacy of Fluanisone can be increased when used in combination with Magnesium sulfate.Experimental
FluconazoleThe therapeutic efficacy of Fluconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FlucytosineThe therapeutic efficacy of Flucytosine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FludiazepamThe therapeutic efficacy of Fludiazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
FlumequineThe serum concentration of Flumequine can be decreased when it is combined with Magnesium sulfate.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be increased when used in combination with Magnesium sulfate.Approved
FlunitrazepamThe therapeutic efficacy of Flunitrazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe therapeutic efficacy of Flupentixol can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
FluphenazineThe therapeutic efficacy of Fluphenazine can be increased when used in combination with Magnesium sulfate.Approved
FlurazepamThe therapeutic efficacy of Flurazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
FluspirileneThe therapeutic efficacy of Fluspirilene can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Fluticasone propionateThe therapeutic efficacy of Fluticasone propionate can be increased when used in combination with Magnesium sulfate.Approved
FlutrimazoleThe therapeutic efficacy of Flutrimazole can be increased when used in combination with Magnesium sulfate.Experimental
FluvoxamineThe therapeutic efficacy of Fluvoxamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FosphenytoinThe therapeutic efficacy of Fosphenytoin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FospropofolThe therapeutic efficacy of Fospropofol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
Gabapentin EnacarbilThe therapeutic efficacy of Gabapentin Enacarbil can be increased when used in combination with Magnesium sulfate.Approved, Investigational
GallamineMagnesium sulfate may increase the neuromuscular blocking activities of Gallamine.Experimental
Gallamine TriethiodideMagnesium sulfate may increase the neuromuscular blocking activities of Gallamine Triethiodide.Approved
GallopamilThe risk or severity of hypotension and neuromuscular blockade can be increased when Gallopamil is combined with Magnesium sulfate.Investigational
Gamma Hydroxybutyric AcidThe therapeutic efficacy of Gamma Hydroxybutyric Acid can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
GarenoxacinThe serum concentration of Garenoxacin can be decreased when it is combined with Magnesium sulfate.Investigational
GatifloxacinThe serum concentration of Gatifloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
GemifloxacinThe serum concentration of Gemifloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
GepironeThe therapeutic efficacy of Gepirone can be increased when used in combination with Magnesium sulfate.Investigational
GlutethimideThe therapeutic efficacy of Glutethimide can be increased when used in combination with Magnesium sulfate.Approved, Illicit
GlyphosateThe therapeutic efficacy of Glyphosate can be increased when used in combination with Magnesium sulfate.Experimental
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Withdrawn
GriseofulvinThe therapeutic efficacy of Griseofulvin can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
GuanfacineThe therapeutic efficacy of Guanfacine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
HachimycinThe therapeutic efficacy of Hachimycin can be increased when used in combination with Magnesium sulfate.Experimental
HalazepamThe therapeutic efficacy of Halazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
HaloperidolThe therapeutic efficacy of Haloperidol can be increased when used in combination with Magnesium sulfate.Approved
HaloproginThe therapeutic efficacy of Haloprogin can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
HalothaneThe therapeutic efficacy of Halothane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
HeroinThe therapeutic efficacy of Heroin can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
HexetidineThe therapeutic efficacy of Hexetidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
HexobarbitalThe therapeutic efficacy of Hexobarbital can be increased when used in combination with Magnesium sulfate.Approved
HydrocodoneMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe therapeutic efficacy of Hydromorphone can be increased when used in combination with Magnesium sulfate.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
IloperidoneThe therapeutic efficacy of Iloperidone can be increased when used in combination with Magnesium sulfate.Approved
ImipramineThe therapeutic efficacy of Imipramine can be increased when used in combination with Magnesium sulfate.Approved
IndalpineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Indalpine.Investigational, Withdrawn
IndiplonThe therapeutic efficacy of Indiplon can be increased when used in combination with Magnesium sulfate.Investigational
IndoraminThe risk or severity of hypotension can be increased when Indoramin is combined with Magnesium sulfate.Withdrawn
IsoconazoleThe therapeutic efficacy of Isoconazole can be increased when used in combination with Magnesium sulfate.Approved
IsofluraneThe therapeutic efficacy of Isoflurane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
IsradipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Isradipine is combined with Magnesium sulfate.Approved, Investigational
ItraconazoleThe therapeutic efficacy of Itraconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
KetamineThe therapeutic efficacy of Ketamine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
KetazolamThe therapeutic efficacy of Ketazolam can be increased when used in combination with Magnesium sulfate.Approved
KetobemidoneThe therapeutic efficacy of Ketobemidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
KetoconazoleThe therapeutic efficacy of Ketoconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LabetalolThe risk or severity of hypotension can be increased when Labetalol is combined with Magnesium sulfate.Approved
LacidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lacidipine is combined with Magnesium sulfate.Approved, Investigational
LamotrigineThe therapeutic efficacy of Lamotrigine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LercanidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lercanidipine is combined with Magnesium sulfate.Approved, Investigational
LevetiracetamThe therapeutic efficacy of Levetiracetam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevobupivacaineThe therapeutic efficacy of Levobupivacaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevocabastineThe therapeutic efficacy of Levocabastine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevocetirizineThe therapeutic efficacy of Levocetirizine can be increased when used in combination with Magnesium sulfate.Approved
LevodopaThe therapeutic efficacy of Levodopa can be increased when used in combination with Magnesium sulfate.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
Levomethadyl AcetateThe therapeutic efficacy of Levomethadyl Acetate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe therapeutic efficacy of Levorphanol can be increased when used in combination with Magnesium sulfate.Approved
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium sulfate.Approved
LidocaineThe therapeutic efficacy of Lidocaine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
LidoflazineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lidoflazine is combined with Magnesium sulfate.Experimental
Lipoic AcidMagnesium sulfate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Nutraceutical
LisdexamfetamineThe risk or severity of hypotension can be increased when Lisdexamfetamine is combined with Magnesium sulfate.Approved, Investigational
Lithium cationThe therapeutic efficacy of Lithium can be increased when used in combination with Magnesium sulfate.Experimental
LofentanilThe therapeutic efficacy of Lofentanil can be increased when used in combination with Magnesium sulfate.Illicit
LofexidineThe therapeutic efficacy of Magnesium sulfate can be increased when used in combination with Lofexidine.Approved, Investigational
LomefloxacinThe serum concentration of Lomefloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
LoperamideThe risk or severity of hypotension and neuromuscular blockade can be increased when Loperamide is combined with Magnesium sulfate.Approved
LoprazolamThe therapeutic efficacy of Loprazolam can be increased when used in combination with Magnesium sulfate.Experimental
LoratadineThe therapeutic efficacy of Loratadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LorazepamThe therapeutic efficacy of Lorazepam can be increased when used in combination with Magnesium sulfate.Approved
LormetazepamThe therapeutic efficacy of Lormetazepam can be increased when used in combination with Magnesium sulfate.Approved
LoxapineThe therapeutic efficacy of Loxapine can be increased when used in combination with Magnesium sulfate.Approved
LurasidoneThe therapeutic efficacy of Lurasidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Magnesium hydroxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Magnesium sulfate is combined with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Magnesium sulfate is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of hypotension and neuromuscular blockade can be increased when Magnesium sulfate is combined with Magnesium salicylate.Approved
ManidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium sulfate.Approved, Investigational
MaprotilineThe therapeutic efficacy of Maprotiline can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MebicarThe therapeutic efficacy of Mebicar can be increased when used in combination with Magnesium sulfate.Experimental
MeclizineThe therapeutic efficacy of Meclizine can be increased when used in combination with Magnesium sulfate.Approved
MedazepamThe therapeutic efficacy of Medazepam can be increased when used in combination with Magnesium sulfate.Experimental
MedetomidineThe therapeutic efficacy of Medetomidine can be increased when used in combination with Magnesium sulfate.Vet Approved
MefloquineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mefloquine.Approved, Investigational
MelatoninThe therapeutic efficacy of Melatonin can be increased when used in combination with Magnesium sulfate.Approved, Nutraceutical, Vet Approved
MelperoneThe therapeutic efficacy of Melperone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MentholThe risk or severity of hypotension and neuromuscular blockade can be increased when Menthol is combined with Magnesium sulfate.Approved
MepartricinThe therapeutic efficacy of Mepartricin can be increased when used in combination with Magnesium sulfate.Experimental
MepivacaineThe therapeutic efficacy of Mepivacaine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
MeprobamateThe therapeutic efficacy of Meprobamate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MeptazinolThe therapeutic efficacy of Meptazinol can be increased when used in combination with Magnesium sulfate.Experimental
MesoridazineThe therapeutic efficacy of Mesoridazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MetaxaloneThe therapeutic efficacy of Metaxalone can be increased when used in combination with Magnesium sulfate.Approved
MethadoneThe therapeutic efficacy of Methadone can be increased when used in combination with Magnesium sulfate.Approved
Methadyl AcetateThe therapeutic efficacy of Methadyl Acetate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MethapyrileneThe therapeutic efficacy of Methapyrilene can be increased when used in combination with Magnesium sulfate.Withdrawn
MethaqualoneThe therapeutic efficacy of Methaqualone can be increased when used in combination with Magnesium sulfate.Illicit, Withdrawn
MethocarbamolThe therapeutic efficacy of Methocarbamol can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
MethohexitalThe therapeutic efficacy of Methohexital can be increased when used in combination with Magnesium sulfate.Approved
MethotrimeprazineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe therapeutic efficacy of Methoxyflurane can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MethsuximideThe therapeutic efficacy of Methsuximide can be increased when used in combination with Magnesium sulfate.Approved
MethylecgonineThe therapeutic efficacy of Methylecgonine can be increased when used in combination with Magnesium sulfate.Experimental
MethylphenobarbitalThe therapeutic efficacy of Methylphenobarbital can be increased when used in combination with Magnesium sulfate.Approved
MetocurineMagnesium sulfate may increase the neuromuscular blocking activities of Metocurine.Approved
Metocurine IodideMagnesium sulfate may increase the neuromuscular blocking activities of Metocurine Iodide.Approved, Withdrawn
MetyrosineMagnesium sulfate may increase the sedative activities of Metyrosine.Approved
MevastatinThe therapeutic efficacy of Mevastatin can be increased when used in combination with Magnesium sulfate.Experimental
MianserinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mianserin.Approved, Investigational
MibefradilThe risk or severity of hypotension and neuromuscular blockade can be increased when Mibefradil is combined with Magnesium sulfate.Investigational, Withdrawn
MicafunginThe therapeutic efficacy of Micafungin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MiconazoleThe therapeutic efficacy of Miconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MidazolamThe therapeutic efficacy of Midazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Milnacipran.Approved, Investigational
MiltefosineThe therapeutic efficacy of Miltefosine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Investigational
MirtazapineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumMagnesium sulfate may increase the neuromuscular blocking activities of Mivacurium.Approved
MolindoneThe therapeutic efficacy of Molindone can be increased when used in combination with Magnesium sulfate.Approved
MonensinThe therapeutic efficacy of Monensin can be increased when used in combination with Magnesium sulfate.Vet Approved
MorphineThe therapeutic efficacy of Morphine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MoxifloxacinThe serum concentration of Moxifloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium sulfate.Approved
MyxothiazolThe therapeutic efficacy of Myxothiazol can be increased when used in combination with Magnesium sulfate.Experimental
NabiloneThe therapeutic efficacy of Nabilone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
NafcillinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Nafcillin.Approved, Investigational
NaftifineThe therapeutic efficacy of Naftifine can be increased when used in combination with Magnesium sulfate.Approved
NaftopidilThe risk or severity of hypotension and neuromuscular blockade can be increased when Naftopidil is combined with Magnesium sulfate.Investigational
NalbuphineThe therapeutic efficacy of Nalbuphine can be increased when used in combination with Magnesium sulfate.Approved
Nalidixic AcidThe serum concentration of Nalidixic Acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
NatamycinThe therapeutic efficacy of Natamycin can be increased when used in combination with Magnesium sulfate.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Nefazodone.Approved, Withdrawn
NemonoxacinThe serum concentration of Nemonoxacin can be decreased when it is combined with Magnesium sulfate.Investigational
NeosaxitoxinMagnesium sulfate may increase the neuromuscular blocking activities of Neosaxitoxin.Investigational
NicardipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nicardipine is combined with Magnesium sulfate.Approved, Investigational
NicergolineThe risk or severity of hypotension can be increased when Nicergoline is combined with Magnesium sulfate.Approved, Investigational
NifedipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nifedipine is combined with Magnesium sulfate.Approved
NifuratelThe therapeutic efficacy of Nifuratel can be increased when used in combination with Magnesium sulfate.Experimental
NiguldipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Niguldipine is combined with Magnesium sulfate.Experimental
Nikkomycin ZThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Magnesium sulfate.Investigational
NiludipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Niludipine is combined with Magnesium sulfate.Experimental
NilvadipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nilvadipine is combined with Magnesium sulfate.Approved, Investigational
NimesulideThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimesulide is combined with Magnesium sulfate.Approved, Investigational, Withdrawn
NimodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium sulfate.Approved, Investigational
NisoldipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nisoldipine is combined with Magnesium sulfate.Approved
NitrazepamThe therapeutic efficacy of Nitrazepam can be increased when used in combination with Magnesium sulfate.Approved
NitrendipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nitrendipine is combined with Magnesium sulfate.Approved, Investigational
NitroprussideMagnesium sulfate may increase the hypotensive activities of Nitroprusside.Approved, Investigational
Nitrous oxideThe therapeutic efficacy of Nitrous oxide can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
NitroxolineThe therapeutic efficacy of Nitroxoline can be increased when used in combination with Magnesium sulfate.Approved
NordazepamThe therapeutic efficacy of Nordazepam can be increased when used in combination with Magnesium sulfate.Approved
NorfloxacinThe serum concentration of Norfloxacin can be decreased when it is combined with Magnesium sulfate.Approved
NorfluraneThe therapeutic efficacy of Norflurane can be increased when used in combination with Magnesium sulfate.Approved, Investigational
NormethadoneThe therapeutic efficacy of Normethadone can be increased when used in combination with Magnesium sulfate.Approved, Illicit
NortriptylineThe therapeutic efficacy of Nortriptyline can be increased when used in combination with Magnesium sulfate.Approved
NylidrinThe risk or severity of hypotension and neuromuscular blockade can be increased when Nylidrin is combined with Magnesium sulfate.Approved
NystatinThe therapeutic efficacy of Nystatin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
OfloxacinThe serum concentration of Ofloxacin can be decreased when it is combined with Magnesium sulfate.Approved
OlanzapineThe therapeutic efficacy of Olanzapine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
OlopatadineThe therapeutic efficacy of Olopatadine can be increased when used in combination with Magnesium sulfate.Approved
OmoconazoleThe therapeutic efficacy of Omoconazole can be increased when used in combination with Magnesium sulfate.Experimental
OndansetronThe therapeutic efficacy of Ondansetron can be increased when used in combination with Magnesium sulfate.Approved
OpiumThe therapeutic efficacy of Opium can be increased when used in combination with Magnesium sulfate.Approved, Illicit
OrlistatThe serum concentration of Magnesium sulfate can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe therapeutic efficacy of Osanetant can be increased when used in combination with Magnesium sulfate.Investigational
OtiloniumThe risk or severity of hypotension and neuromuscular blockade can be increased when Otilonium is combined with Magnesium sulfate.Experimental, Investigational
OxazepamThe therapeutic efficacy of Oxazepam can be increased when used in combination with Magnesium sulfate.Approved
OxiconazoleThe therapeutic efficacy of Oxiconazole can be increased when used in combination with Magnesium sulfate.Approved
Oxolinic acidThe serum concentration of Oxolinic acid can be decreased when it is combined with Magnesium sulfate.Experimental
OxprenololThe therapeutic efficacy of Oxprenolol can be increased when used in combination with Magnesium sulfate.Approved
OxybuprocaineThe therapeutic efficacy of Oxybuprocaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
OxycodoneThe therapeutic efficacy of Oxycodone can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
OxymorphoneThe therapeutic efficacy of Oxymorphone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
OxytetracyclineMagnesium sulfate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
PafuramidineThe therapeutic efficacy of Pafuramidine can be increased when used in combination with Magnesium sulfate.Investigational
PaliperidoneThe therapeutic efficacy of Paliperidone can be increased when used in combination with Magnesium sulfate.Approved
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Magnesium sulfate.Approved
PancuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Pancuronium.Approved
ParaldehydeMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Paroxetine.Approved, Investigational
PazufloxacinThe serum concentration of Pazufloxacin can be decreased when it is combined with Magnesium sulfate.Investigational
PefloxacinThe serum concentration of Pefloxacin can be decreased when it is combined with Magnesium sulfate.Approved
PenfluridolThe therapeutic efficacy of Penfluridol can be increased when used in combination with Magnesium sulfate.Experimental
PentamidineThe therapeutic efficacy of Pentamidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PentazocineThe therapeutic efficacy of Pentazocine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PentobarbitalThe therapeutic efficacy of Pentobarbital can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
PerazineThe therapeutic efficacy of Perazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PerospironeThe therapeutic efficacy of Perospirone can be increased when used in combination with Magnesium sulfate.Approved
PerphenazineThe therapeutic efficacy of Perphenazine can be increased when used in combination with Magnesium sulfate.Approved
PethidineThe therapeutic efficacy of Pethidine can be increased when used in combination with Magnesium sulfate.Approved
PhenazocineThe therapeutic efficacy of Phenazocine can be increased when used in combination with Magnesium sulfate.Experimental
PhenibutThe therapeutic efficacy of Phenibut can be increased when used in combination with Magnesium sulfate.Experimental
PhenobarbitalThe therapeutic efficacy of Phenobarbital can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PhenoperidineThe therapeutic efficacy of Phenoperidine can be increased when used in combination with Magnesium sulfate.Experimental
PhenoxybenzamineThe risk or severity of hypotension can be increased when Phenoxybenzamine is combined with Magnesium sulfate.Approved
PhenoxyethanolThe therapeutic efficacy of Phenoxyethanol can be increased when used in combination with Magnesium sulfate.Approved
PhentolamineThe risk or severity of hypotension can be increased when Phentolamine is combined with Magnesium sulfate.Approved
PhenytoinThe therapeutic efficacy of Phenytoin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PimozideThe therapeutic efficacy of Pimozide can be increased when used in combination with Magnesium sulfate.Approved
PinaveriumThe risk or severity of hypotension and neuromuscular blockade can be increased when Pinaverium is combined with Magnesium sulfate.Approved
PipamperoneThe therapeutic efficacy of Pipamperone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PipecuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Pipecuronium.Approved
Pipemidic acidThe serum concentration of Pipemidic acid can be decreased when it is combined with Magnesium sulfate.Experimental
PipotiazineThe therapeutic efficacy of Pipotiazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PiritramideThe therapeutic efficacy of Piritramide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Piromidic acidThe serum concentration of Piromidic acid can be decreased when it is combined with Magnesium sulfate.Experimental
PizotifenThe therapeutic efficacy of Pizotifen can be increased when used in combination with Magnesium sulfate.Approved
PomalidomideThe therapeutic efficacy of Pomalidomide can be increased when used in combination with Magnesium sulfate.Approved
PosaconazoleThe therapeutic efficacy of Posaconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
PramipexoleMagnesium sulfate may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe therapeutic efficacy of Pramocaine can be increased when used in combination with Magnesium sulfate.Approved
PrazepamThe therapeutic efficacy of Prazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
PrazosinThe risk or severity of hypotension can be increased when Prazosin is combined with Magnesium sulfate.Approved
PregabalinThe therapeutic efficacy of Pregabalin can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
PrenylamineThe risk or severity of hypotension and neuromuscular blockade can be increased when Prenylamine is combined with Magnesium sulfate.Withdrawn
PrilocaineThe therapeutic efficacy of Prilocaine can be increased when used in combination with Magnesium sulfate.Approved
PrimidoneThe therapeutic efficacy of Primidone can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ProcaineThe therapeutic efficacy of Procaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ProchlorperazineThe therapeutic efficacy of Prochlorperazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PromazineThe therapeutic efficacy of Promazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PromethazineThe therapeutic efficacy of Promethazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PropanididThe therapeutic efficacy of Propanidid can be increased when used in combination with Magnesium sulfate.Experimental
ProparacaineThe therapeutic efficacy of Proparacaine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PropericiazineThe risk or severity of hypotension can be increased when Propericiazine is combined with Magnesium sulfate.Approved, Investigational
PropiomazineThe risk or severity of hypotension can be increased when Propiomazine is combined with Magnesium sulfate.Approved
PropiverineThe risk or severity of hypotension can be increased when Propiverine is combined with Magnesium sulfate.Approved, Investigational
PropofolThe therapeutic efficacy of Propofol can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
PropoxycaineThe therapeutic efficacy of Propoxycaine can be increased when used in combination with Magnesium sulfate.Approved
ProtriptylineThe therapeutic efficacy of Protriptyline can be increased when used in combination with Magnesium sulfate.Approved
ProxibarbalThe therapeutic efficacy of Proxibarbal can be increased when used in combination with Magnesium sulfate.Experimental
PrulifloxacinThe serum concentration of Prulifloxacin can be decreased when it is combined with Magnesium sulfate.Investigational
PSD502The therapeutic efficacy of PSD502 can be increased when used in combination with Magnesium sulfate.Investigational
PyrantelMagnesium sulfate may increase the neuromuscular blocking activities of Pyrantel.Approved, Vet Approved
PyrrolnitrinThe therapeutic efficacy of Pyrrolnitrin can be increased when used in combination with Magnesium sulfate.Experimental
QuazepamThe therapeutic efficacy of Quazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
QuetiapineThe therapeutic efficacy of Quetiapine can be increased when used in combination with Magnesium sulfate.Approved
QuinidineThe risk or severity of hypotension can be increased when Quinidine is combined with Magnesium sulfate.Approved, Investigational
QuinisocaineThe therapeutic efficacy of Quinisocaine can be increased when used in combination with Magnesium sulfate.Experimental
RacepinephrineThe risk or severity of hypotension can be increased when Racepinephrine is combined with Magnesium sulfate.Approved
RacloprideThe therapeutic efficacy of Raclopride can be increased when used in combination with Magnesium sulfate.Investigational
RadicicolThe therapeutic efficacy of Radicicol can be increased when used in combination with Magnesium sulfate.Experimental
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Magnesium sulfate.Approved
RamelteonThe therapeutic efficacy of Ramelteon can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RapacuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RemifentanilThe therapeutic efficacy of Remifentanil can be increased when used in combination with Magnesium sulfate.Approved
RemoxiprideThe therapeutic efficacy of Remoxipride can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
ReserpineThe therapeutic efficacy of Reserpine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RifabutinThe risk or severity of hypotension can be increased when Rifabutin is combined with Magnesium sulfate.Approved, Investigational
RifampicinThe risk or severity of hypotension can be increased when Rifampicin is combined with Magnesium sulfate.Approved
RifapentineThe risk or severity of hypotension can be increased when Rifapentine is combined with Magnesium sulfate.Approved, Investigational
RifaximinThe risk or severity of hypotension can be increased when Rifaximin is combined with Magnesium sulfate.Approved, Investigational
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
RisperidoneThe therapeutic efficacy of Risperidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RitanserinThe therapeutic efficacy of Ritanserin can be increased when used in combination with Magnesium sulfate.Investigational
RocuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Rocuronium.Approved
RomifidineThe therapeutic efficacy of Romifidine can be increased when used in combination with Magnesium sulfate.Vet Approved
RopiniroleMagnesium sulfate may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe therapeutic efficacy of Ropivacaine can be increased when used in combination with Magnesium sulfate.Approved
RosoxacinThe serum concentration of Rosoxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
RotigotineMagnesium sulfate may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Magnesium sulfate.Approved
RufloxacinThe serum concentration of Rufloxacin can be decreased when it is combined with Magnesium sulfate.Experimental
Salicylhydroxamic AcidThe therapeutic efficacy of Salicylhydroxamic Acid can be increased when used in combination with Magnesium sulfate.Experimental
Salicylic acidThe therapeutic efficacy of Salicylic acid can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ScopolamineThe therapeutic efficacy of Scopolamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SecobarbitalThe therapeutic efficacy of Secobarbital can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
SeletracetamThe risk or severity of hypotension and neuromuscular blockade can be increased when Seletracetam is combined with Magnesium sulfate.Investigational
SepranoloneThe therapeutic efficacy of Sepranolone can be increased when used in combination with Magnesium sulfate.Investigational
SertaconazoleThe therapeutic efficacy of Sertaconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SertindoleThe therapeutic efficacy of Sertindole can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Sertraline.Approved
SevofluraneThe therapeutic efficacy of Sevoflurane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
SilodosinThe risk or severity of hypotension can be increased when Silodosin is combined with Magnesium sulfate.Approved
SinefunginThe therapeutic efficacy of Sinefungin can be increased when used in combination with Magnesium sulfate.Experimental
SirolimusThe therapeutic efficacy of Sirolimus can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SitafloxacinThe serum concentration of Sitafloxacin can be decreased when it is combined with Magnesium sulfate.Experimental, Investigational
Sodium glycerophosphateThe serum concentration of Sodium glycerophosphate can be decreased when it is combined with Magnesium sulfate.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
Sodium phosphate, monobasicThe serum concentration of Sodium phosphate can be decreased when it is combined with Magnesium sulfate.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
StiripentolThe therapeutic efficacy of Stiripentol can be increased when used in combination with Magnesium sulfate.Approved
SuccinylcholineMagnesium sulfate may increase the neuromuscular blocking activities of Succinylcholine.Approved
SufentanilThe therapeutic efficacy of Sufentanil can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SulconazoleThe therapeutic efficacy of Sulconazole can be increased when used in combination with Magnesium sulfate.Approved
SulpirideThe therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SultoprideThe therapeutic efficacy of Sultopride can be increased when used in combination with Magnesium sulfate.Experimental
SuvorexantMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TamsulosinThe risk or severity of hypotension can be increased when Tamsulosin is combined with Magnesium sulfate.Approved, Investigational
TandospironeThe therapeutic efficacy of Tandospirone can be increased when used in combination with Magnesium sulfate.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
TasimelteonThe therapeutic efficacy of Tasimelteon can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TavaboroleThe therapeutic efficacy of Tavaborole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Technetium Tc-99m etidronateThe serum concentration of Technetium Tc-99m etidronate can be decreased when it is combined with Magnesium sulfate.Approved
Technetium Tc-99m medronateThe serum concentration of Technetium Tc-99m medronate can be decreased when it is combined with Magnesium sulfate.Approved
TemafloxacinThe serum concentration of Temafloxacin can be decreased when it is combined with Magnesium sulfate.Withdrawn
TemazepamThe therapeutic efficacy of Temazepam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TerazosinThe risk or severity of hypotension can be increased when Terazosin is combined with Magnesium sulfate.Approved
TerbinafineThe therapeutic efficacy of Terbinafine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
TerconazoleThe therapeutic efficacy of Terconazole can be increased when used in combination with Magnesium sulfate.Approved
TerodilineThe risk or severity of hypotension and neuromuscular blockade can be increased when Terodiline is combined with Magnesium sulfate.Experimental
TetrabenazineThe therapeutic efficacy of Tetrabenazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TetracaineThe therapeutic efficacy of Tetracaine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
TetracyclineMagnesium sulfate can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
TetrahydropalmatineThe therapeutic efficacy of Tetrahydropalmatine can be increased when used in combination with Magnesium sulfate.Investigational
TetrodotoxinThe therapeutic efficacy of Tetrodotoxin can be increased when used in combination with Magnesium sulfate.Investigational
ThalidomideMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe therapeutic efficacy of Thiamylal can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ThiopentalThe therapeutic efficacy of Thiopental can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ThioproperazineThe risk or severity of hypotension can be increased when Thioproperazine is combined with Magnesium sulfate.Approved
ThioridazineThe therapeutic efficacy of Thioridazine can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
ThiothixeneThe therapeutic efficacy of Thiothixene can be increased when used in combination with Magnesium sulfate.Approved
ThymolThe therapeutic efficacy of Thymol can be increased when used in combination with Magnesium sulfate.Approved
TiagabineThe therapeutic efficacy of Tiagabine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TiaprideThe therapeutic efficacy of Tiapride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TiletamineThe therapeutic efficacy of Tiletamine can be increased when used in combination with Magnesium sulfate.Vet Approved
TilidineThe therapeutic efficacy of Tilidine can be increased when used in combination with Magnesium sulfate.Experimental
Tiludronic acidThe serum concentration of Tiludronic acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
TioconazoleThe therapeutic efficacy of Tioconazole can be increased when used in combination with Magnesium sulfate.Approved
TizanidineThe therapeutic efficacy of Tizanidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TolazolineThe risk or severity of hypotension can be increased when Tolazoline is combined with Magnesium sulfate.Approved, Vet Approved
TolcaponeThe therapeutic efficacy of Tolcapone can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
TolciclateThe therapeutic efficacy of Tolciclate can be increased when used in combination with Magnesium sulfate.Experimental
TolevamerThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Tolevamer.Approved, Investigational
Tolfenamic AcidThe risk or severity of hypotension and neuromuscular blockade can be increased when Tolfenamic Acid is combined with Magnesium sulfate.Approved, Investigational
TolnaftateThe therapeutic efficacy of Tolnaftate can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
TopiramateThe therapeutic efficacy of Topiramate can be increased when used in combination with Magnesium sulfate.Approved
TramadolThe therapeutic efficacy of Tramadol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TranilastThe risk or severity of hypotension and neuromuscular blockade can be increased when Tranilast is combined with Magnesium sulfate.Approved, Investigational
TranylcypromineThe therapeutic efficacy of Tranylcypromine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrazodoneThe therapeutic efficacy of Trazodone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TriazolamThe therapeutic efficacy of Triazolam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Tricaine methanesulfonateThe therapeutic efficacy of Tricaine methanesulfonate can be increased when used in combination with Magnesium sulfate.Vet Approved
TrichloroethyleneThe therapeutic efficacy of Trichloroethylene can be increased when used in combination with Magnesium sulfate.Approved
TriethylenetetramineThe serum concentration of Magnesium sulfate can be decreased when it is combined with Triethylenetetramine.Approved, Investigational
TrifluoperazineThe therapeutic efficacy of Trifluoperazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrifluperidolThe therapeutic efficacy of Trifluperidol can be increased when used in combination with Magnesium sulfate.Experimental
TriflupromazineThe therapeutic efficacy of Triflupromazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
TrimazosinThe risk or severity of hypotension can be increased when Trimazosin is combined with Magnesium sulfate.Experimental
TrimebutineThe risk or severity of hypotension and neuromuscular blockade can be increased when Trimebutine is combined with Magnesium sulfate.Approved
TrimethadioneThe risk or severity of hypotension and neuromuscular blockade can be increased when Trimethadione is combined with Magnesium sulfate.Approved
TrimetrexateThe therapeutic efficacy of Trimetrexate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrimipramineThe therapeutic efficacy of Trimipramine can be increased when used in combination with Magnesium sulfate.Approved
TriprolidineThe therapeutic efficacy of Triprolidine can be increased when used in combination with Magnesium sulfate.Approved
TrovafloxacinThe serum concentration of Trovafloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Withdrawn
TubocurarineMagnesium sulfate may increase the neuromuscular blocking activities of Tubocurarine.Approved
UrapidilThe risk or severity of hypotension can be increased when Urapidil is combined with Magnesium sulfate.Investigational
Valproic AcidThe therapeutic efficacy of Valproic Acid can be increased when used in combination with Magnesium sulfate.Approved, Investigational
VecuroniumMagnesium sulfate may increase the neuromuscular blocking activities of Vecuronium.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Venlafaxine.Approved
VeraliprideThe therapeutic efficacy of Veralipride can be increased when used in combination with Magnesium sulfate.Experimental
VerapamilThe risk or severity of hypotension and neuromuscular blockade can be increased when Verapamil is combined with Magnesium sulfate.Approved
VigabatrinThe therapeutic efficacy of Vigabatrin can be increased when used in combination with Magnesium sulfate.Approved
VinpocetineThe risk or severity of hypotension and neuromuscular blockade can be increased when Vinpocetine is combined with Magnesium sulfate.Investigational
Vinyl etherThe therapeutic efficacy of Vinyl ether can be increased when used in combination with Magnesium sulfate.Experimental
VoriconazoleThe therapeutic efficacy of Voriconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
VortioxetineThe therapeutic efficacy of Vortioxetine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
WIN 55212-2The risk or severity of hypotension and neuromuscular blockade can be increased when WIN 55212-2 is combined with Magnesium sulfate.Experimental
WortmanninThe therapeutic efficacy of Wortmannin can be increased when used in combination with Magnesium sulfate.Experimental
XenonThe therapeutic efficacy of Xenon can be increased when used in combination with Magnesium sulfate.Experimental
XylazineThe therapeutic efficacy of Xylazine can be increased when used in combination with Magnesium sulfate.Vet Approved
ZaleplonThe therapeutic efficacy of Zaleplon can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
ZiconotideThe therapeutic efficacy of Ziconotide can be increased when used in combination with Magnesium sulfate.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Zimelidine.Withdrawn
ZiprasidoneThe therapeutic efficacy of Ziprasidone can be increased when used in combination with Magnesium sulfate.Approved
ZolazepamThe therapeutic efficacy of Zolazepam can be increased when used in combination with Magnesium sulfate.Vet Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Magnesium sulfate.Approved
ZolpidemMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe therapeutic efficacy of Zonisamide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ZopicloneThe therapeutic efficacy of Zopiclone can be increased when used in combination with Magnesium sulfate.Approved
ZotepineThe therapeutic efficacy of Zotepine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ZuclopenthixolThe therapeutic efficacy of Zuclopenthixol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Shinichi Yamamoto, Akifumi Sekitani, "BASIC MAGNESIUM SULFATE GRANULE, AND PROCESS FOR PRODUCTION THEREOF." U.S. Patent US20110042297, issued February 24, 2011.

US20110042297
General References
  1. Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. [PubMed:16002955]
  2. Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY: Prolonged maternal magnesium administration and bone metabolism in neonates. Early Hum Dev. 2010 Mar;86(3):187-91. doi: 10.1016/j.earlhumdev.2010.02.007. Epub 2010 Mar 12. [PubMed:20226604]
  3. Wedig KE, Kogan J, Schorry EK, Whitsett JA: Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4. [PubMed:16724078]
  4. Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM: Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. Acta Obstet Gynecol Scand. 2006;85(9):1099-103. [PubMed:16929415]
  5. Malaeb SN, Rassi AI, Haddad MC, Seoud MA, Yunis KA: Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol. 2004 May;34(5):384-6. Epub 2004 Feb 18. [PubMed:14985884]
  6. Matsuda Y, Maeda Y, Ito M, Sakamoto H, Masaoka N, Takada M, Sato K: Effect of magnesium sulfate treatment on neonatal bone abnormalities. Gynecol Obstet Invest. 1997;44(2):82-8. [PubMed:9286718]
  7. Schanler RJ, Smith LG Jr, Burns PA: Effects of long-term maternal intravenous magnesium sulfate therapy on neonatal calcium metabolism and bone mineral content. Gynecol Obstet Invest. 1997;43(4):236-41. [PubMed:9194621]
  8. Santi MD, Henry GW, Douglas GL: Magnesium sulfate treatment of preterm labor as a cause of abnormal neonatal bone mineralization. J Pediatr Orthop. 1994 Mar-Apr;14(2):249-53. [PubMed:8188843]
  9. Holcomb WL Jr, Shackelford GD, Petrie RH: Magnesium tocolysis and neonatal bone abnormalities: a controlled study. Obstet Gynecol. 1991 Oct;78(4):611-4. [PubMed:1923163]
  10. Cumming WA, Thomas VJ: Hypermagnesemia: a cause of abnormal metaphyses in the neonate. AJR Am J Roentgenol. 1989 May;152(5):1071-2. [PubMed:2705341]
  11. Lamm CI, Norton KI, Murphy RJ, Wilkins IA, Rabinowitz JG: Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr. 1988 Dec;113(6):1078-82. [PubMed:3193315]
  12. McGuinness GA, Weinstein MM, Cruikshank DP, Pitkin RM: Effects of magnesium sulfate treatment on perinatal calcium metabolism. II. Neonatal responses. Obstet Gynecol. 1980 Nov;56(5):595-600. [PubMed:7432730]
  13. Riaz M, Porat R, Brodsky NL, Hurt H: The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998 Nov-Dec;18(6 Pt 1):449-54. [PubMed:9848759]
External Links
Human Metabolome Database
HMDB0014791
KEGG Drug
D01108
PubChem Compound
24083
PubChem Substance
46508411
ChemSpider
22515
ChEBI
32599
ChEMBL
CHEMBL2021423
Therapeutic Targets Database
DAP000201
PharmGKB
PA450302
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Magnesium_sulfate
ATC Codes
A06AD04 — Magnesium sulfateV04CC02 — Magnesium sulfateA12CC02 — Magnesium sulfateD11AX05 — Magnesium sulfateB05XA05 — Magnesium sulfate
AHFS Codes
  • 56:12.00 — Cathartics and Laxatives
  • 28:12.92 — Miscellaneous Anticonvulsants
  • 40:12.00 — Replacement Preparations
MSDS
Download (72.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticPremature Births1
1CompletedPreventionPaclitaxel-induced Neuropathy1
1CompletedSupportive CareHead and Neck Carcinoma1
1Not Yet RecruitingTreatmentCraniotomy / High Blood Pressure (Hypertension)1
1RecruitingTreatmentStroke, Ischemic1
1, 2CompletedPreventionPost Operative Pain1
1, 2CompletedTreatmentStroke, Acute1
1, 2CompletedTreatmentProphylaxis of preeclampsia1
1, 2RecruitingNot AvailableLack of Drug Action1
1, 2RecruitingTreatmentEpstein-Barr Virus (EBV) Infection and Neoplasia / X-linked Immunodeficiency With Magnesium Defect1
2Active Not RecruitingTreatmentMuscle Relaxation1
2CompletedPreventionAnalgesia1
2CompletedSupportive CareIdiopathic Scoliosis1
2CompletedTreatmentBronchiolitis / Magnesium, Abnormal Blood Level1
2CompletedTreatmentHand, Foot, and Mouth Disease1
2CompletedTreatmentNeuromuscular Block1
2RecruitingDiagnosticPain1
2RecruitingTreatmentPain, Neuropathic1
2RecruitingTreatmentSedation, Conscious1
2TerminatedTreatmentTraumatic Brain Injury (TBI)1
2, 3Active Not RecruitingTreatmentPostoperative pain1
2, 3CompletedPreventionCerebral Palsy (CP) / Premature Labour1
2, 3CompletedPreventionCesarean Section; Shivering1
2, 3CompletedTreatmentPerinatal Anoxic-ischemic Brain Injury1
2, 3CompletedTreatmentPost Partum Severe Preeclampsia / Severe Pre-eclampsia Postpartum1
2, 3CompletedTreatmentPostoperative pain1
2, 3CompletedTreatmentSevere Pre-eclampsia With Postnatal Complication1
2, 3CompletedTreatmentSickle Cell Disorders1
2, 3RecruitingPreventionPostoperative pain1
2, 3RecruitingTreatmentAcidosis, Respiratory / Alcohol Withdrawal Syndrome(AWS) / Magnesium Deficiency / Vitamin B1 deficiency / Wernicke's encephalopathy1
2, 3WithdrawnPreventionChronic Hypertension / Gestational Hypertension / Preeclampsia / Pregnancy associated hypertension / Superimposed Preeclampsia1
2, 3WithdrawnTreatmentAsthma Bronchial1
2, 3WithdrawnTreatmentHeadaches1
3CompletedPreventionCerebral Palsy (CP) / Intraventricular Hemorrhage / Periventricular Leukomalacia / Premature separation of placenta / Pulmonary Edemas1
3CompletedPreventionIncreased Intra Ocular Pressure (IOP)1
3CompletedPreventionNeoplasms, Brain / Seizures (Incl Subtypes)1
3CompletedPreventionSubarachnoid Hemorrhage1
3CompletedPreventionProphylaxis of preeclampsia1
3CompletedSupportive CareChemotherapeutic Agent Toxicity / Colorectal Cancers / Neuropathy / Neurotoxicity1
3CompletedSupportive CareColorectal Cancers / Neurotoxicity1
3CompletedTreatmentAcute Exacerbation of Chronic Obstructive Pulmonary Disease1
3CompletedTreatmentBrain Injury / Concussion, Brain / Craniocerebral Injuries1
3CompletedTreatmentCerebrovascular Accidents1
3CompletedTreatmentNonvalvular Atrial Fibrillation1
3CompletedTreatmentParents2
3CompletedTreatmentPerinatal Asphyxia , Moderate to Severe HIE1
3CompletedTreatmentSickle Cell Disorders1
3Not Yet RecruitingTreatmentThrombotic Thrombocytopenic Purpura (TTP)1
3RecruitingPreventionCerebral Palsy (CP)1
3RecruitingTreatmentBronchial Asthma1
3RecruitingTreatmentCesarean Section1
3RecruitingTreatmentHealthy Volunteers1
3TerminatedPreventionTransient Neurologic Syndrome1
3TerminatedSupportive CareNeuropathy / Pain / Recurrent Breast Carcinoma / Stage IV Breast Cancer1
3Unknown StatusPreventionBrain Injury / Cerebral Palsy (CP)1
3Unknown StatusPreventionModerate Hypoxic Ischemic Encephalopathy / Severe Hypoxic Ischemic Encephalopathy1
4CompletedNot AvailableNeuromuscular Block1
4CompletedPreventionCardiovascular Morbidity / Intubation Complications1
4CompletedPreventionHemorrhage1
4CompletedPreventionHyperalgesia1
4CompletedPreventionLiving Donor Liver Transplantation / Reperfusion Injury1
4CompletedPreventionNeoplasm, Gastric1
4CompletedPreventionPostoperative pain1
4CompletedSupportive CareLumbar Spine Disc Herniation1
4CompletedSupportive CarePreeclampsia1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Hypocalcemia / Infections, Cytomegalovirus1
4CompletedTreatmentAdjunct to general anesthesia therapy / Intravenous Anesthesia1
4CompletedTreatmentKnee Replacement Surgery1
4CompletedTreatmentNeuromuscular Blockade3
4CompletedTreatmentPostoperative pain1
4CompletedTreatmentPre-eclampsia Aggravated1
4CompletedTreatmentPreeclampsia1
4CompletedTreatmentSupratentorial Brain Tumor1
4Enrolling by InvitationDiagnosticColonoscopy1
4Not Yet RecruitingDiagnosticPreeclampsia1
4Not Yet RecruitingTreatmentNeuromuscular Blockade1
4Not Yet RecruitingTreatmentPreeclampsia Severe1
4RecruitingPreventionArrythmias1
4RecruitingPreventionPain in Pediatric Patients1
4RecruitingPreventionPreterm Labor Without Delivery1
4RecruitingPreventionPsychomotor Agitation1
4RecruitingSupportive CareChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingSupportive CareMalnutrition1
4RecruitingTreatmentAsthma Bronchial1
4RecruitingTreatmentDeep Neuromuscular Blockade / Magnesium Sulfate / Neuromuscular Blockade / Rocuronium1
4RecruitingTreatmentPostoperative pain1
4RecruitingTreatmentSevere Preeclampsia1
4TerminatedPreventionPreeclampsia1
4TerminatedPreventionPremature Labour1
4TerminatedSupportive CareArthritis Knee / Dexmedetomidine / Magnesium Sulfate1
4TerminatedTreatmentMagnesium Sulphate / Pain / Post Pulmonary Resection1
4Unknown StatusNot AvailableEmergence Agitation in Children / Emergence Delirium / Postopertive Delirium1
4Unknown StatusPreventionAcute Agitation / Pediatric Disorder1
4WithdrawnTreatmentPulmonary Disease, Chronic Obstructive1
Not AvailableActive Not RecruitingOtherPregnancy associated hypertension / Prophylaxis of preeclampsia1
Not AvailableCompletedNot AvailableAsthma Bronchial / Chronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedNot AvailableCancer, Breast1
Not AvailableCompletedNot AvailableEasy of Laryngoscopy Manipulation / Heart Rate / Mean Arterial Pressure / Patient Reaction to Intubation and Cuff Inflation / Vocal Cord Position or Movement1
Not AvailableCompletedNot AvailableHypertensive Disorder of Pregnancy1
Not AvailableCompletedNot AvailableIntubating Conditions1
Not AvailableCompletedNot AvailableMagnesium Sulfate Pharmacokinetics and Pharmacodynamics1
Not AvailableCompletedNot AvailablePreeclampsia / Pregnancy1
Not AvailableCompletedNot AvailableSevere Sepsis / Shock, Septic1
Not AvailableCompletedOtherBreast Surgery1
Not AvailableCompletedOtherPain / Postoperative pain1
Not AvailableCompletedPreventionBenign muscle neoplasm1
Not AvailableCompletedPreventionColorectal Cancers1
Not AvailableCompletedPreventionNonvalvular Atrial Fibrillation1
Not AvailableCompletedPreventionNonvalvular Atrial Fibrillation / Pain, Neuropathic1
Not AvailableCompletedPreventionOpioid Use, Unspecified, Uncomplicated / Pain1
Not AvailableCompletedPreventionPost Operative Sore Throat1
Not AvailableCompletedPreventionProphylaxis of preeclampsia1
Not AvailableCompletedTreatmentAlagille Syndrome / Biliary Atresia / Cholestasis1
Not AvailableCompletedTreatmentAsthma Bronchial1
Not AvailableCompletedTreatmentIntubation Conditions / Observation of Neuromuscular Block / Surgical Conditions1
Not AvailableCompletedTreatmentNonvalvular Atrial Fibrillation1
Not AvailableCompletedTreatmentObstetric Labour, Premature1
Not AvailableCompletedTreatmentPremature separation of placenta1
Not AvailableCompletedTreatmentRadius Fractures1
Not AvailableCompletedTreatmentWheezy Bronchitis1
Not AvailableNot Yet RecruitingNot AvailablePreeclampsia1
Not AvailableNot Yet RecruitingPreventionProstatic Neoplasms1
Not AvailableNot Yet RecruitingTreatmentAsthma Acute / Asthma in Children1
Not AvailableNot Yet RecruitingTreatmentNeoplasms, Thyroid1
Not AvailableRecruitingNot AvailableNeuromuscular Blockade1
Not AvailableRecruitingNot AvailablePostpartum Depression1
Not AvailableRecruitingPreventionAnaesthesia therapy1
Not AvailableRecruitingPreventionEmergence Delirium1
Not AvailableRecruitingPreventionPain1
Not AvailableRecruitingTreatmentIschemia, Brain / Strokes1
Not AvailableRecruitingTreatmentNonvalvular Atrial Fibrillation1
Not AvailableRecruitingTreatmentPostpartum Hemorrhage1
Not AvailableRecruitingTreatmentPremature Labour1
Not AvailableTerminatedSupportive CarePostoperative pain1
Not AvailableTerminatedTreatmentPremature Births / Premature Labour1
Not AvailableTerminatedTreatmentPreterm Premature Rupture of Membranes1
Not AvailableTerminatedTreatmentPrimary Hypomagnesemia (Disorder)1
Not AvailableUnknown StatusNot AvailableCerebral Aneurysms1
Not AvailableUnknown StatusNot AvailableHallux Valgus1
Not AvailableUnknown StatusPreventionPain2
Not AvailableUnknown StatusPreventionPostoperative pain1
Not AvailableUnknown StatusTreatmentAcute Severe Asthma1
Not AvailableUnknown StatusTreatmentAsthma Bronchial1
Not AvailableUnknown StatusTreatmentMuscle Relaxation1

Pharmacoeconomics

Manufacturers
  • Abraxis pharmaceutical products
  • Hospira inc
Packagers
  • Denison Pharmaceuticals Inc.
  • Gallipot
  • Hospira Inc.
  • Pharmakon
  • Pharmedium
  • QOL Medical
  • Spectrum Pharmaceuticals
  • Vi-Jon Laboratories Inc.
  • Walgreen Co.
Dosage forms
FormRouteStrength
SolutionIntramuscular; Intravenous500 mg
TabletOral
Powder, for solutionOral
Capsule, liquid filledOral
CapsuleOral
LiquidOral
InjectionIntrathecal
OintmentTopical400 mg/g
CrystalOral; Topical1 g/g
GranuleOral1 g/g
GranuleOral100 kg/100kg
GranuleOral; Topical1 g/g
GranuleOral; Topical1.81 kg/100kg
Granule, for solutionOral; Topical1 g/g
Granule, for solutionOral; Topical100 g/100g
Powder, for solutionOral100 %
GranuleTopical2.72 kg/2.72kg
GranuleOral; Topical100 g/100g
PowderOral
PowderOral100 %
GranuleOral100 g/100g
Granule, for solutionOral1 g/g
Powder, for solutionOral1000 mg/g
Injection, emulsionIntravenous
InjectionIntravenous1 g/100mL
InjectionIntravenous2 g/50mL
InjectionIntravenous20 g/500mL
InjectionIntravenous4 g/100mL
InjectionIntravenous4 g/50mL
InjectionIntravenous40 g/1000mL
Injection, solutionIntramuscular; Intravenous.5 g/mL
Injection, solutionIntramuscular; Intravenous500 mg/mL
Injection, solutionIntravenous20 g/500mL
Injection, solutionIntravenous20 g/250mL
Injection, solutionIntravenous4 g/50mL
Injection, solutionIntravenous4 g/100mL
Injection, solutionIntravenous40 mg/mL
Injection, solutionIntravenous80 mg/mL
LiquidTopical45 %
Injection, solutionIntravenous1 g/100mL
Injection, solutionIntravenous10 mg/mL
Injection, solutionIntravenous20 mg/mL
LiquidIntramuscular; Intravenous200 mg
LiquidIntramuscular500 mg
LiquidIntramuscular; Intravenous500 mg
Granule, for solutionOral; Topical1 kg/kg
LiquidIntravenous
PowderTopical10 g/10g
CrystalOral; Topical100 g/100g
For solutionTopical1 kg/kg
GranuleOral3.63 kg/3.63kg
Granule, for solutionOral1 kg/kg
EmulsionIntravenous
KitOral
Solution, concentrateOral
LiquidIrrigation
SolutionIntravenous
Prices
Unit descriptionCostUnit
Elliotts b solution ampule4.71USD ml
Magnesium Sulfate 50% Solution 2ml Vial0.92USD vial
Magnesium sulfate powder0.29USD g
Magnesium-ns 6 g/50 ml bag0.29USD ml
Magnesium-ns 4 g/50 ml bag0.27USD ml
Magnesium-ns 3 g/50 ml bag0.26USD ml
Magnesium sulfate-ns 2 gm bag0.25USD ml
Magnesium sulfate-ns 1 gm bag0.24USD ml
Magnesium-d5w 1 gm/100 ml soln0.07USD ml
Magnesium-lr 20 g/500 ml0.03USD ml
Magnesium-lr 40 g/500 ml bag0.03USD ml
Magnesium-lr 50 g/500 ml bag0.02USD ml
Epsom salt 100% powder0.01USD g
Magnesium sulf 4% iv soln0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6946149No2003-03-072023-03-07Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)1124 °C (decomposition)Not Available
water solubility710 mg/mLNot Available
logP-0.91Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7487
Blood Brain Barrier+0.9646
Caco-2 permeable-0.6267
P-glycoprotein substrateNon-substrate0.9137
P-glycoprotein inhibitor INon-inhibitor0.9194
P-glycoprotein inhibitor IINon-inhibitor0.9904
Renal organic cation transporterNon-inhibitor0.9521
CYP450 2C9 substrateNon-substrate0.8775
CYP450 2D6 substrateNon-substrate0.8213
CYP450 3A4 substrateNon-substrate0.7007
CYP450 1A2 substrateNon-inhibitor0.7767
CYP450 2C9 inhibitorNon-inhibitor0.7602
CYP450 2D6 inhibitorNon-inhibitor0.9115
CYP450 2C19 inhibitorNon-inhibitor0.7547
CYP450 3A4 inhibitorNon-inhibitor0.9759
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9577
Ames testNon AMES toxic0.5773
CarcinogenicityCarcinogens 0.8111
BiodegradationReady biodegradable0.943
Rat acute toxicity2.4160 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7988
hERG inhibition (predictor II)Non-inhibitor0.9446
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkaline earth metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkaline earth metal oxoanionic compounds
Sub Class
Alkaline earth metal sulfates
Direct Parent
Alkaline earth metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkaline earth metal sulfate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
magnesium salt, metal sulfate (CHEBI:32599)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only...
Gene Name
CACNG1
Uniprot ID
Q06432
Uniprot Name
Voltage-dependent calcium channel gamma-1 subunit
Molecular Weight
25028.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-...
Gene Name
CACNA2D1
Uniprot ID
P54289
Uniprot Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
Molecular Weight
124566.93 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1C
Uniprot ID
Q13936
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1C
Molecular Weight
248974.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB1
Uniprot ID
Q02641
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-1
Molecular Weight
65712.995 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB2
Uniprot ID
Q08289
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-2
Molecular Weight
73579.925 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1S
Uniprot ID
Q13698
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1S
Molecular Weight
212348.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Drug created on June 13, 2005 07:24 / Updated on July 16, 2018 21:15