Identification

Name
Magnesium sulfate
Accession Number
DB00653  (APRD01080)
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Structure
Thumb
Synonyms
  • Magnesium sulfate (1:1)
  • Magnesium sulfate anhydrous
  • Magnesium sulphate
  • magnesium(II) sulfate
  • Magnesiumsulfat
  • MgSO4
Product Ingredients
IngredientUNIICASInChI Key
Magnesium sulfate heptahydrateSK47B8698T10034-99-8WRUGWIBCXHJTDG-UHFFFAOYSA-L
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
50% Magnesium Sulfate Injection USPSolution500 mgIntramuscular; IntravenousHospira, Inc.1975-12-31Not applicableCanada
Magnesium SulfateInjection, solution4 g/100mLIntravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2015-09-16Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousFresenius Kabi2016-01-29Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousMedical Purchasing Solutions, Llc2000-08-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousFresenius Kabi2000-08-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousCardinal Health2000-08-08Not applicableUs
Magnesium SulfateInjection, solution4 g/50mLIntravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2017-01-13Not applicableUs
Magnesium SulfateInjection, solution4 g/100mLIntravenousA S Medication Solutions1994-06-242017-06-20Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousX Gen Pharmaceuticals, Inc.2014-02-23Not applicableUs
Magnesium SulfateInjection40 g/1000mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Magnesium SulfateInjection1 g/100mLIntravenousWG Critical Care, LLC2016-03-08Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousExela Pharma Sciences, Llc.2014-02-23Not applicableUs
Magnesium SulfateInjection2 g/50mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution80 mg/mLIntravenousFresenius Kabi Norge As2017-08-01Not applicableUs
Magnesium SulfateInjection, solution80 mg/mLIntravenousFresenius Kabi2016-03-15Not applicableUs
Magnesium SulfateInjection20 g/500mLIntravenousWG Critical Care, LLC2018-01-09Not applicableUs
Magnesium SulfateInjection, solution500 mg/mLIntramuscular; IntravenousPhysicians Total Care, Inc.2006-12-12Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Assured Epsom SaltGranule100 g/100gOralHefei Yatai Daily Chemical Products Co., Ltd.2016-03-30Not applicableUs
Assured Epsom SaltGranule100 g/100gOralGreenbrier International, Inc.2016-06-14Not applicableUs
EpsalOintment400 mg/gTopicalPress Chemical And Pharmaceutical Laboratories1957-01-15Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalWinco Foods2015-05-21Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalVi Jon1998-07-15Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalSupervalu2005-03-21Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalPublix Supermarkets, Inc.2014-09-05Not applicableUs
Epsom SaltGranule100 kg/100kgOralWestern Family1998-06-05Not applicableUs
Epsom SaltGranule, for solution1 g/gOral; TopicalTopco Associates1999-07-15Not applicableUs
Epsom SaltGranule1 g/gOralPublix Supermarkets, Inc.2013-07-03Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium Lactate Et Magnesium SulfateMagnesium sulfate (65 mg) + Calcium lactate (260 mg)TabletOralBio Vita1987-12-312005-07-20Canada
ColPrep KitMagnesium sulfate (1.6 g/22.7g) + Potassium sulfate (3.13 g/22.7g) + Sodium sulfate (17.5 g/22.7g)Powder, for solutionOralKvk Tech,Inc2016-12-27Not applicableUs
Eau Purgative RigaMagnesium sulfate (2.4 g) + Sodium sulfate (1.056 g)LiquidOralGlendale Agencies1978-12-311996-11-29Canada
Elliotts BMagnesium sulfate (3 mg/10mL) + Calcium Chloride (2 mg/10mL) + D-glucose (8 mg/10mL) + Potassium Chloride (3 mg/10mL) + Sodium Chloride (73 mg/10mL) + Sodium bicarbonate (19 mg/10mL) + Sodium phosphate, monobasic (2 mg/10mL)InjectionIntrathecalQOL Medical, LLC.2006-09-27Not applicableUs
Elliotts BMagnesium sulfate (3 mg/10mL) + Calcium Chloride (2 mg/10mL) + D-glucose (8 mg/10mL) + Potassium Chloride (3 mg/10mL) + Sodium Chloride (73 mg/10mL) + Sodium bicarbonate (19 mg/10mL) + Sodium phosphate, monobasic (2 mg/10mL)InjectionIntrathecalLukare Medical, Llc2013-06-04Not applicableUs
Formule 1705 - LiqMagnesium sulfate (250 mg) + Ox bile extract (1.56 mg)LiquidOralBio Vita1993-12-312003-07-16Canada
KabivenMagnesium sulfate heptahydrate (96 mg/100mL) + Calcium Chloride (29 mg/100mL) + D-glucose monohydrate (9.8 g/100mL) + Glutamic Acid (164 mg/100mL) + Glycine (231 mg/100mL) + Histidine (199 mg/100mL) + L-Alanine (467 mg/100mL) + L-Arginine (330 mg/100mL) + L-Aspartic Acid (99 mg/100mL) + L-Isoleucine (164 mg/100mL) + L-Leucine (231 mg/100mL) + L-Lysine hydrochloride (263 mg/100mL) + L-Phenylalanine (231 mg/100mL) + L-Proline (199 mg/100mL) + L-Threonine (164 mg/100mL) + L-Tryptophan (55 mg/100mL) + L-Tyrosine (6.7 mg/100mL) + L-Valine (213 mg/100mL) + Methionine (164 mg/100mL) + Potassium Chloride (174 mg/100mL) + Serine (131 mg/100mL) + Sodium acetate (239 mg/100mL) + Sodium glycerophosphate (147 mg/100mL) + Soybean oil (3.9 g/100mL)Injection, emulsionIntravenousFresenius Kabi2014-08-25Not applicableUs
Magnesium CapMagnesium sulfate (111 mg) + Magnesium oxide (82 mg)CapsuleOralAlsi Cie Ltee1983-12-312002-06-12Canada
Magnesium Sulfate In 5% Dextrose Inj(20mg/ml)Magnesium sulfate (20 mg) + Dextrose, unspecified form (50 mg)SolutionIntravenousHospira, Inc.1996-12-30Not applicableCanada
Multiple Electrolyte Additive InjMagnesium sulfate (19.8 mg) + Calcium gluconate (20.6 mg) + Potassium Chloride (29.8 mg) + Sodium Chloride (46.6 mg)LiquidIntravenousInternational Medication Systems, Limited1980-12-311997-08-15Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CentratexMagnesium sulfate (6.9 mg/1) + Cupric sulfate (.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic Acid (1 mg/1) + Iron (106 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate (18.2 mg/1)CapsuleOralCenturion Labs2009-06-14Not applicableUs
Concept DHAMagnesium sulfate (5 mg/1) + Ascorbic acid (25 mg/1) + Biotin (300 ug/1) + Cupric sulfate (2 mg/1) + Cyanocobalamin (12.5 ug/1) + Folic Acid (1 mg/1) + Iron (53.5 mg/1) + Iron (38 mg/1) + Niacin (1.8 mg/1) + Omega-3-acid ethyl esters (200 mg/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc sulfate (10 mg/1)Capsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBMagnesium sulfate (6.9 mg/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cupric sulfate (800 ug/1) + Cyanocobalamin (10 ug/1) + Folic Acid (1 mg/1) + Iron (130 mg/1) + Iron (92.4 mg/1) + Manganese sulfate (1.3 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate (18.2 mg/1)CapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate heptahydrate (.5 g/mL)Injection, solutionIntramuscular; IntravenousGeneral Injectables & Vaccines2010-08-012017-01-28Us
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousCardinal Health2000-08-082017-07-19Us
Magnesium SulfateMagnesium sulfate (20 g/250mL)Injection, solutionIntravenousCantrell Drug Company2011-07-25Not applicableUs
Magnesium SulfateMagnesium sulfate heptahydrate (500 mg/mL)Injection, solutionIntramuscular; IntravenousAmerican Regent1990-09-302017-07-20Us
Magnesium SulfateMagnesium sulfate (20 g/500mL)Injection, solutionIntravenousCantrell Drug Company2011-02-21Not applicableUs
Categories
UNII
ML30MJ2U7I
CAS number
7487-88-9
Weight
Average: 120.368
Monoisotopic: 119.936771076
Chemical Formula
MgO4S
InChI Key
CSNNHWWHGAXBCP-UHFFFAOYSA-L
InChI
InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
IUPAC Name
magnesium(2+) ion sulfate
SMILES
[Mg++].[O-]S([O-])(=O)=O

Pharmacology

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.

Associated Conditions
Associated Therapies
Pharmacodynamics

Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.

Mechanism of action

Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Magnesium sulfate reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. Additionally, Magnesium inhibits Ca2+ influx through dihydropyridine-sensitive, voltage-dependent channels. This accounts for much of its relaxant action on vascular smooth muscle.

TargetActionsOrganism
UVoltage-dependent calcium channel gamma-1 subunitNot AvailableHuman
UVoltage-dependent calcium channel subunit alpha-2/delta-1Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit alpha-1CNot AvailableHuman
UVoltage-dependent L-type calcium channel subunit beta-1Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit beta-2Not AvailableHuman
UVoltage-dependent L-type calcium channel subunit alpha-1SNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding

25-30%

Metabolism

None

Route of elimination

Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.

Half life

43.2 hours (for newborns)

Clearance
Not Available
Toxicity

LD50 = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(2-benzhydryloxyethyl)diethyl-methylammonium iodideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with (2-benzhydryloxyethyl)diethyl-methylammonium iodide.Experimental
2,5-Dimethoxy-4-ethylthioamphetamineThe therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Magnesium sulfate.Experimental
3-Aza-2,3-Dihydrogeranyl DiphosphateThe serum concentration of 3-Aza-2,3-Dihydrogeranyl Diphosphate can be decreased when it is combined with Magnesium sulfate.Experimental
3-isobutyl-1-methyl-7H-xanthineMagnesium sulfate may increase the excretion rate of 3-isobutyl-1-methyl-7H-xanthine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
3,4-MethylenedioxyamphetamineThe therapeutic efficacy of 3,4-Methylenedioxyamphetamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamineThe therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
4-MethoxyamphetamineThe therapeutic efficacy of 4-Methoxyamphetamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
5-methoxy-N,N-dimethyltryptamineThe therapeutic efficacy of 5-methoxy-N,N-dimethyltryptamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
6-O-benzylguanineMagnesium sulfate may increase the excretion rate of 6-O-benzylguanine which could result in a lower serum level and potentially a reduction in efficacy.Investigational
7-DeazaguanineMagnesium sulfate may increase the excretion rate of 7-Deazaguanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
7-NitroindazoleThe therapeutic efficacy of 7-Nitroindazole can be increased when used in combination with Magnesium sulfate.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe therapeutic efficacy of 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be increased when used in combination with Magnesium sulfate.Experimental
7,9-DimethylguanineMagnesium sulfate may increase the excretion rate of 7,9-Dimethylguanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
8-azaguanineMagnesium sulfate may increase the excretion rate of 8-azaguanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
8-chlorotheophyllineMagnesium sulfate may increase the excretion rate of 8-chlorotheophylline which could result in a lower serum level and potentially a reduction in efficacy.Approved
9-DeazaguanineMagnesium sulfate may increase the excretion rate of 9-Deazaguanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
9-MethylguanineMagnesium sulfate may increase the excretion rate of 9-Methylguanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
AbafunginThe therapeutic efficacy of Abafungin can be increased when used in combination with Magnesium sulfate.Investigational
AcefyllineMagnesium sulfate may increase the excretion rate of Acefylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
AcepromazineThe therapeutic efficacy of Acepromazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
AceprometazineThe therapeutic efficacy of Aceprometazine can be increased when used in combination with Magnesium sulfate.Approved
AcetazolamideThe therapeutic efficacy of Acetazolamide can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
AcetophenazineThe therapeutic efficacy of Acetophenazine can be increased when used in combination with Magnesium sulfate.Approved
Acetylglycinamide chloral hydrateThe therapeutic efficacy of Acetylglycinamide chloral hydrate can be increased when used in combination with Magnesium sulfate.Experimental
AclidiniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Aclidinium.Approved
AcyclovirMagnesium sulfate may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.Approved
AdinazolamThe therapeutic efficacy of Adinazolam can be increased when used in combination with Magnesium sulfate.Approved
AdipiplonThe therapeutic efficacy of Adipiplon can be increased when used in combination with Magnesium sulfate.Investigational
AgmatineThe risk or severity of hypotension and neuromuscular blockade can be increased when Agmatine is combined with Magnesium sulfate.Experimental, Investigational
AgomelatineThe therapeutic efficacy of Agomelatine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AlaproclateThe therapeutic efficacy of Alaproclate can be increased when used in combination with Magnesium sulfate.Experimental
AlbaconazoleThe therapeutic efficacy of Albaconazole can be increased when used in combination with Magnesium sulfate.Investigational
AlcuroniumThe therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium sulfate.Experimental
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Magnesium sulfate.Approved
AlfacalcidolThe serum concentration of Magnesium sulfate can be increased when it is combined with Alfacalcidol.Approved, Nutraceutical
AlfaxaloneThe therapeutic efficacy of Alfaxalone can be increased when used in combination with Magnesium sulfate.Vet Approved
AlfentanilThe therapeutic efficacy of Alfentanil can be increased when used in combination with Magnesium sulfate.Approved, Illicit
AlfuzosinThe risk or severity of hypotension can be increased when Alfuzosin is combined with Magnesium sulfate.Approved, Investigational
AlimemazineThe therapeutic efficacy of Alimemazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
AllobarbitalThe therapeutic efficacy of Allobarbital can be increased when used in combination with Magnesium sulfate.Experimental
AllopregnanoloneThe therapeutic efficacy of Allopregnanolone can be increased when used in combination with Magnesium sulfate.Investigational
AlmasilateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Almasilate.Approved, Experimental
AlmotriptanThe therapeutic efficacy of Almotriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AloglutamolThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Aloglutamol.Approved
AlosetronThe therapeutic efficacy of Alosetron can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
AlphacetylmethadolThe therapeutic efficacy of Alphacetylmethadol can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
AlphaprodineThe therapeutic efficacy of Alphaprodine can be increased when used in combination with Magnesium sulfate.Illicit
AlprazolamThe therapeutic efficacy of Alprazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
AlprenololThe therapeutic efficacy of Alprenolol can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
Aluminium acetoacetateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Aluminium acetoacetate.Experimental
Aluminium glycinateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Aluminium glycinate.Experimental
Aluminum hydroxideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Aluminum hydroxide.Approved, Investigational
AlverineThe therapeutic efficacy of Alverine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmikacinThe therapeutic efficacy of Amikacin can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Magnesium sulfate.Approved
AmineptineThe therapeutic efficacy of Amineptine can be increased when used in combination with Magnesium sulfate.Illicit, Withdrawn
AmiodaroneThe risk or severity of hypotension and neuromuscular blockade can be increased when Amiodarone is combined with Magnesium sulfate.Approved, Investigational
AmisulprideThe therapeutic efficacy of Amisulpride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmitriptylineThe therapeutic efficacy of Amitriptyline can be increased when used in combination with Magnesium sulfate.Approved
AmitriptylinoxideThe therapeutic efficacy of Amitriptylinoxide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AmlodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Amlodipine is combined with Magnesium sulfate.Approved
AmobarbitalThe therapeutic efficacy of Amobarbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
AmoxapineThe therapeutic efficacy of Amoxapine can be increased when used in combination with Magnesium sulfate.Approved
AmperozideThe therapeutic efficacy of Amperozide can be increased when used in combination with Magnesium sulfate.Experimental
AmphetamineThe therapeutic efficacy of Amphetamine can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
Amphotericin BMagnesium sulfate may decrease the nephrotoxic activities of Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Magnesium sulfate can be decreased when combined with Amprenavir.Approved, Investigational
AniracetamThe therapeutic efficacy of Aniracetam can be increased when used in combination with Magnesium sulfate.Experimental
Anisotropine MethylbromideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Anisotropine Methylbromide.Approved
ApalutamideThe serum concentration of Magnesium sulfate can be decreased when it is combined with Apalutamide.Approved, Investigational
APD791The therapeutic efficacy of APD791 can be increased when used in combination with Magnesium sulfate.Investigational
ApomorphineThe therapeutic efficacy of Apomorphine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ApramycinThe therapeutic efficacy of Apramycin can be increased when used in combination with Magnesium sulfate.Experimental, Vet Approved
AprepitantThe serum concentration of Magnesium sulfate can be increased when it is combined with Aprepitant.Approved, Investigational
AprobarbitalThe therapeutic efficacy of Aprobarbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ApronalideThe therapeutic efficacy of Apronalide can be increased when used in combination with Magnesium sulfate.Experimental
AranidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Aranidipine is combined with Magnesium sulfate.Approved, Investigational
Arbaclofen PlacarbilThe therapeutic efficacy of Arbaclofen Placarbil can be increased when used in combination with Magnesium sulfate.Investigational
ArbekacinThe therapeutic efficacy of Arbekacin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
AripiprazoleThe therapeutic efficacy of Aripiprazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Aripiprazole lauroxilThe therapeutic efficacy of Aripiprazole lauroxil can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ArotinololThe risk or severity of hypotension can be increased when Arotinolol is combined with Magnesium sulfate.Investigational
AsenapineThe therapeutic efficacy of Asenapine can be increased when used in combination with Magnesium sulfate.Approved
AtazanavirThe metabolism of Magnesium sulfate can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe therapeutic efficacy of Atomoxetine can be increased when used in combination with Magnesium sulfate.Approved
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium sulfate.Approved, Experimental, Investigational
Atracurium besylateThe therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium sulfate.Approved
AtropineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Atropine.Approved, Vet Approved
AzaperoneThe therapeutic efficacy of Azaperone can be increased when used in combination with Magnesium sulfate.Investigational, Vet Approved
AzathioprineMagnesium sulfate may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.Approved
AZD-3043The therapeutic efficacy of AZD-3043 can be increased when used in combination with Magnesium sulfate.Investigational
AzelastineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Azelnidipine is combined with Magnesium sulfate.Approved, Investigational
AzosemideThe risk or severity of adverse effects can be increased when Azosemide is combined with Magnesium sulfate.Investigational
BaclofenThe therapeutic efficacy of Baclofen can be increased when used in combination with Magnesium sulfate.Approved
BamifyllineMagnesium sulfate may increase the excretion rate of Bamifylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
BarbexacloneThe therapeutic efficacy of Barbexaclone can be increased when used in combination with Magnesium sulfate.Experimental
BarbitalThe therapeutic efficacy of Barbital can be increased when used in combination with Magnesium sulfate.Illicit
BarnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Barnidipine is combined with Magnesium sulfate.Approved
BeclamideThe therapeutic efficacy of Beclamide can be increased when used in combination with Magnesium sulfate.Experimental
BekanamycinThe therapeutic efficacy of Bekanamycin can be increased when used in combination with Magnesium sulfate.Experimental
BenactyzineThe therapeutic efficacy of Benactyzine can be increased when used in combination with Magnesium sulfate.Withdrawn
BencyclaneThe risk or severity of hypotension and neuromuscular blockade can be increased when Bencyclane is combined with Magnesium sulfate.Experimental
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Magnesium sulfate.Approved
BenidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Benidipine is combined with Magnesium sulfate.Approved, Investigational
BenmoxinThe therapeutic efficacy of Benmoxin can be increased when used in combination with Magnesium sulfate.Withdrawn
BenperidolThe therapeutic efficacy of Benperidol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BenzatropineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Benzatropine.Approved
BenziloneThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Benzilone.Experimental
BenzoctamineThe therapeutic efficacy of Benzoctamine can be increased when used in combination with Magnesium sulfate.Approved
BenzphetamineThe therapeutic efficacy of Benzphetamine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
BenzquinamideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Benzquinamide.Withdrawn
BenzthiazideThe risk or severity of adverse effects can be increased when Benzthiazide is combined with Magnesium sulfate.Approved
Benzyl alcoholThe therapeutic efficacy of Benzyl alcohol can be increased when used in combination with Magnesium sulfate.Approved
BepridilThe risk or severity of hypotension and neuromuscular blockade can be increased when Bepridil is combined with Magnesium sulfate.Approved, Withdrawn
BesifloxacinMagnesium sulfate can cause a decrease in the absorption of Besifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
BevantololThe risk or severity of hypotension can be increased when Bevantolol is combined with Magnesium sulfate.Approved
BevoniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Bevonium.Experimental
BezitramideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Bezitramide.Experimental, Illicit, Withdrawn
BifemelaneThe therapeutic efficacy of Bifemelane can be increased when used in combination with Magnesium sulfate.Experimental
BifeprunoxThe therapeutic efficacy of Bifeprunox can be increased when used in combination with Magnesium sulfate.Investigational
BifonazoleThe therapeutic efficacy of Bifonazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BioallethrinThe risk or severity of hypotension and neuromuscular blockade can be increased when Bioallethrin is combined with Magnesium sulfate.Approved, Experimental
BiperidenThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Biperiden.Approved, Investigational
BisacodylThe therapeutic efficacy of Bisacodyl can be decreased when used in combination with Magnesium sulfate.Approved
BisoxatinThe therapeutic efficacy of Bisoxatin can be decreased when used in combination with Magnesium sulfate.Approved
BL-1020The therapeutic efficacy of BL-1020 can be increased when used in combination with Magnesium sulfate.Investigational
BlonanserinThe therapeutic efficacy of Blonanserin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BoceprevirThe metabolism of Magnesium sulfate can be decreased when combined with Boceprevir.Approved, Withdrawn
BornaprineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Bornaprine.Experimental
BosentanThe serum concentration of Magnesium sulfate can be decreased when it is combined with Bosentan.Approved, Investigational
Botulinum Toxin Type AThe therapeutic efficacy of Botulinum Toxin Type A can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Botulinum Toxin Type BThe therapeutic efficacy of Botulinum Toxin Type B can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrexpiprazoleThe therapeutic efficacy of Brexpiprazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrimonidineThe therapeutic efficacy of Brimonidine can be increased when used in combination with Magnesium sulfate.Approved
BrinzolamideThe risk or severity of adverse effects can be increased when Brinzolamide is combined with Magnesium sulfate.Approved
BrivaracetamThe therapeutic efficacy of Brivaracetam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrofaromineThe therapeutic efficacy of Brofaromine can be increased when used in combination with Magnesium sulfate.Experimental
BromazepamThe therapeutic efficacy of Bromazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
BromisovalThe therapeutic efficacy of Bromisoval can be increased when used in combination with Magnesium sulfate.Experimental
BromocriptineThe therapeutic efficacy of Bromocriptine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BromotheophyllineMagnesium sulfate may increase the excretion rate of Bromotheophylline which could result in a lower serum level and potentially a reduction in efficacy.Approved
BromperidolThe therapeutic efficacy of Bromperidol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
BrompheniramineThe therapeutic efficacy of Brompheniramine can be increased when used in combination with Magnesium sulfate.Approved
BrotizolamThe therapeutic efficacy of Brotizolam can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
BucindololThe risk or severity of hypotension can be increased when Bucindolol is combined with Magnesium sulfate.Investigational
BuclizineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Buclizine.Approved
BufotenineThe therapeutic efficacy of Bufotenine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
BufyllineMagnesium sulfate may increase the excretion rate of Bufylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Magnesium sulfate.Approved
BunazosinThe risk or severity of hypotension can be increased when Bunazosin is combined with Magnesium sulfate.Investigational
BuprenorphineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe therapeutic efficacy of Bupropion can be increased when used in combination with Magnesium sulfate.Approved
BuspironeThe therapeutic efficacy of Buspirone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ButabarbitalThe therapeutic efficacy of Butabarbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButalbitalThe therapeutic efficacy of Butalbital can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButaperazineThe therapeutic efficacy of Butaperazine can be increased when used in combination with Magnesium sulfate.Experimental
ButethalThe therapeutic efficacy of Butethal can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ButoconazoleThe therapeutic efficacy of Butoconazole can be increased when used in combination with Magnesium sulfate.Approved
ButorphanolThe therapeutic efficacy of Butorphanol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Vet Approved
ButriptylineThe therapeutic efficacy of Butriptyline can be increased when used in combination with Magnesium sulfate.Approved
ButylscopolamineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Butylscopolamine.Approved, Investigational, Vet Approved
CabergolineThe therapeutic efficacy of Cabergoline can be increased when used in combination with Magnesium sulfate.Approved
CafedrineMagnesium sulfate may increase the excretion rate of Cafedrine which could result in a lower serum level and potentially a reduction in efficacy.Investigational
CaffeineMagnesium sulfate may increase the excretion rate of Caffeine which could result in a lower serum level and potentially a reduction in efficacy.Approved
CalcitriolThe serum concentration of Magnesium sulfate can be increased when it is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Acetate.Approved, Investigational
Calcium ChlorideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium lactate.Approved, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium levulinateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium levulinate.Approved, Experimental
Calcium pangamateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium Phosphate.Approved
Calcium phosphate dihydrateThe serum concentration of Calcium phosphate dihydrate can be decreased when it is combined with Magnesium sulfate.Approved
Calcium silicateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium silicate.Experimental
CamazepamThe therapeutic efficacy of Camazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
CamylofinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Camylofin.Experimental
CanagliflozinThe risk or severity of adverse effects can be increased when Canagliflozin is combined with Magnesium sulfate.Approved
CannabidiolThe therapeutic efficacy of Cannabidiol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CannabidivarinThe therapeutic efficacy of Cannabidivarin can be increased when used in combination with Magnesium sulfate.Investigational
Canrenoic acidThe risk or severity of adverse effects can be increased when Canrenoic acid is combined with Magnesium sulfate.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Canrenone is combined with Magnesium sulfate.Investigational
CapreomycinThe therapeutic efficacy of Capreomycin can be increased when used in combination with Magnesium sulfate.Approved
CaptodiameThe therapeutic efficacy of Captodiame can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CarbamazepineThe therapeutic efficacy of Carbamazepine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CarbinoxamineThe therapeutic efficacy of Carbinoxamine can be increased when used in combination with Magnesium sulfate.Approved
CarboxyamidotriazoleThe risk or severity of hypotension and neuromuscular blockade can be increased when Carboxyamidotriazole is combined with Magnesium sulfate.Investigational
CarboxymethylcelluloseThe therapeutic efficacy of Carboxymethylcellulose can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
CarbromalThe therapeutic efficacy of Carbromal can be increased when used in combination with Magnesium sulfate.Experimental
CarfentanilThe therapeutic efficacy of Carfentanil can be increased when used in combination with Magnesium sulfate.Illicit, Investigational, Vet Approved
CariprazineThe therapeutic efficacy of Cariprazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CarisbamateThe therapeutic efficacy of Carisbamate can be increased when used in combination with Magnesium sulfate.Investigational
CarisoprodolThe therapeutic efficacy of Carisoprodol can be increased when used in combination with Magnesium sulfate.Approved
CaroverineThe risk or severity of hypotension and neuromuscular blockade can be increased when Caroverine is combined with Magnesium sulfate.Experimental
CaroxazoneThe therapeutic efficacy of Caroxazone can be increased when used in combination with Magnesium sulfate.Withdrawn
CarvedilolThe risk or severity of hypotension can be increased when Carvedilol is combined with Magnesium sulfate.Approved, Investigational
Castor oilThe therapeutic efficacy of Castor oil can be decreased when used in combination with Magnesium sulfate.Approved, Investigational, Nutraceutical, Vet Approved
CathinoneThe therapeutic efficacy of Cathinone can be increased when used in combination with Magnesium sulfate.Illicit
CeritinibThe serum concentration of Magnesium sulfate can be increased when it is combined with Ceritinib.Approved
CerlapirdineThe therapeutic efficacy of Cerlapirdine can be increased when used in combination with Magnesium sulfate.Investigational
CetirizineThe therapeutic efficacy of Cetirizine can be increased when used in combination with Magnesium sulfate.Approved
Chloral hydrateThe therapeutic efficacy of Chloral hydrate can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe therapeutic efficacy of Chlordiazepoxide can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
ChlormezanoneThe therapeutic efficacy of Chlormezanone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ChloroquineThe therapeutic efficacy of Chloroquine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Chlorothiazide is combined with Magnesium sulfate.Approved, Vet Approved
ChlorphenamineThe therapeutic efficacy of Chlorphenamine can be increased when used in combination with Magnesium sulfate.Approved
ChlorphenesinThe therapeutic efficacy of Chlorphenesin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved, Withdrawn
ChlorphenoxamineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Chlorphenoxamine.Withdrawn
ChlorproethazineThe therapeutic efficacy of Chlorproethazine can be increased when used in combination with Magnesium sulfate.Experimental
ChlorpromazineThe therapeutic efficacy of Chlorpromazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ChlorprothixeneThe therapeutic efficacy of Chlorprothixene can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ChlortetracyclineThe therapeutic efficacy of Chlortetracycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Magnesium sulfate.Approved
ChlorzoxazoneThe therapeutic efficacy of Chlorzoxazone can be increased when used in combination with Magnesium sulfate.Approved
CicletanineThe risk or severity of adverse effects can be increased when Cicletanine is combined with Magnesium sulfate.Investigational
CilansetronThe therapeutic efficacy of Cilansetron can be increased when used in combination with Magnesium sulfate.Investigational
CilnidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Cilnidipine is combined with Magnesium sulfate.Approved, Investigational
CimetidineThe serum concentration of Magnesium sulfate can be increased when it is combined with Cimetidine.Approved, Investigational
CinitaprideThe therapeutic efficacy of Cinitapride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
CinnarizineThe risk or severity of hypotension and neuromuscular blockade can be increased when Cinnarizine is combined with Magnesium sulfate.Approved, Investigational
CinolazepamThe therapeutic efficacy of Cinolazepam can be increased when used in combination with Magnesium sulfate.Approved
CinoxacinMagnesium sulfate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
CiprofloxacinMagnesium sulfate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
CisaprideThe therapeutic efficacy of Cisapride can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
CisatracuriumThe therapeutic efficacy of Cisatracurium can be increased when used in combination with Magnesium sulfate.Approved
CitalopramThe therapeutic efficacy of Citalopram can be increased when used in combination with Magnesium sulfate.Approved
ClarithromycinThe metabolism of Magnesium sulfate can be decreased when combined with Clarithromycin.Approved
ClemastineThe therapeutic efficacy of Clemastine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ClevidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Clevidipine is combined with Magnesium sulfate.Approved, Investigational
ClidiniumThe therapeutic efficacy of Clidinium can be increased when used in combination with Magnesium sulfate.Approved
ClindamycinThe therapeutic efficacy of Clindamycin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ClobazamThe therapeutic efficacy of Clobazam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
Clodronic AcidThe serum concentration of Clodronic Acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
ClofenamideThe risk or severity of adverse effects can be increased when Clofenamide is combined with Magnesium sulfate.Experimental
clomethiazoleThe therapeutic efficacy of clomethiazole can be increased when used in combination with Magnesium sulfate.Investigational
ClomipramineThe therapeutic efficacy of Clomipramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ClomocyclineThe therapeutic efficacy of Clomocycline can be increased when used in combination with Magnesium sulfate.Approved
ClonazepamThe therapeutic efficacy of Clonazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ClonidineThe therapeutic efficacy of Clonidine can be increased when used in combination with Magnesium sulfate.Approved
ClopamideThe risk or severity of adverse effects can be increased when Clopamide is combined with Magnesium sulfate.Experimental
ClopenthixolThe therapeutic efficacy of Clopenthixol can be increased when used in combination with Magnesium sulfate.Experimental
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Magnesium sulfate.Approved
ClorazepateThe therapeutic efficacy of Clorazepate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ClorexoloneThe risk or severity of adverse effects can be increased when Clorexolone is combined with Magnesium sulfate.Experimental
ClothiapineThe therapeutic efficacy of Clothiapine can be increased when used in combination with Magnesium sulfate.Experimental
ClotiazepamThe therapeutic efficacy of Clotiazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ClotrimazoleThe metabolism of Magnesium sulfate can be decreased when combined with Clotrimazole.Approved, Vet Approved
CloxazolamThe therapeutic efficacy of Cloxazolam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ClozapineThe therapeutic efficacy of Clozapine can be increased when used in combination with Magnesium sulfate.Approved
CobicistatThe metabolism of Magnesium sulfate can be decreased when combined with Cobicistat.Approved
CocaineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
ColistimethateThe therapeutic efficacy of Colistimethate can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ColistinThe therapeutic efficacy of Colistin can be increased when used in combination with Magnesium sulfate.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Magnesium sulfate.Approved, Investigational
CrizotinibThe metabolism of Magnesium sulfate can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Magnesium sulfate can be decreased when combined with Curcumin.Approved, Investigational
CyamemazineThe therapeutic efficacy of Cyamemazine can be increased when used in combination with Magnesium sulfate.Approved
CyclandelateThe risk or severity of hypotension and neuromuscular blockade can be increased when Cyclandelate is combined with Magnesium sulfate.Approved
CyclizineThe therapeutic efficacy of Cyclizine can be increased when used in combination with Magnesium sulfate.Approved
CyclobarbitalThe therapeutic efficacy of Cyclobarbital can be increased when used in combination with Magnesium sulfate.Experimental
CyclobenzaprineThe therapeutic efficacy of Cyclobenzaprine can be increased when used in combination with Magnesium sulfate.Approved
CyclopentamineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Cyclopentamine.Withdrawn
CyclopenthiazideThe risk or severity of adverse effects can be increased when Cyclopenthiazide is combined with Magnesium sulfate.Experimental
CyclopentolateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Cyclopentolate.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
CyclopropaneThe therapeutic efficacy of Cyclopropane can be increased when used in combination with Magnesium sulfate.Experimental
CyclosporineThe therapeutic efficacy of Cyclosporine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Cyclothiazide is combined with Magnesium sulfate.Approved
CycrimineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Cycrimine.Approved
CyproheptadineThe therapeutic efficacy of Cyproheptadine can be increased when used in combination with Magnesium sulfate.Approved
DabrafenibThe serum concentration of Magnesium sulfate can be decreased when it is combined with Dabrafenib.Approved, Investigational
DanazolThe metabolism of Magnesium sulfate can be decreased when combined with Danazol.Approved
DanthronThe therapeutic efficacy of Danthron can be decreased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
DantroleneThe therapeutic efficacy of Dantrolene can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DapagliflozinThe risk or severity of adverse effects can be increased when Dapagliflozin is combined with Magnesium sulfate.Approved
DapiprazoleThe therapeutic efficacy of Dapiprazole can be increased when used in combination with Magnesium sulfate.Approved
DapoxetineThe therapeutic efficacy of Dapoxetine can be increased when used in combination with Magnesium sulfate.Investigational
DarifenacinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Darifenacin.Approved, Investigational
DarodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Darodipine is combined with Magnesium sulfate.Experimental
DarunavirThe metabolism of Magnesium sulfate can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Magnesium sulfate can be increased when it is combined with Dasatinib.Approved, Investigational
DeanolThe therapeutic efficacy of Deanol can be increased when used in combination with Magnesium sulfate.Experimental
DecamethoniumThe therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium sulfate.Approved
DeferasiroxThe serum concentration of Magnesium sulfate can be decreased when it is combined with Deferasirox.Approved, Investigational
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Magnesium sulfate.Approved
DelavirdineThe metabolism of Magnesium sulfate can be decreased when combined with Delavirdine.Approved
DelorazepamThe therapeutic efficacy of Delorazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
DemeclocyclineThe therapeutic efficacy of Demeclocycline can be increased when used in combination with Magnesium sulfate.Approved
DeramciclaneThe therapeutic efficacy of Deramciclane can be increased when used in combination with Magnesium sulfate.Investigational
DesfluraneThe therapeutic efficacy of Desflurane can be increased when used in combination with Magnesium sulfate.Approved
DesipramineThe therapeutic efficacy of Desipramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DesloratadineThe therapeutic efficacy of Desloratadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DesvenlafaxineThe therapeutic efficacy of Desvenlafaxine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DetomidineThe therapeutic efficacy of Detomidine can be increased when used in combination with Magnesium sulfate.Vet Approved
DexamethasoneThe serum concentration of Magnesium sulfate can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe therapeutic efficacy of Dexbrompheniramine can be increased when used in combination with Magnesium sulfate.Approved
DexetimideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Dexetimide.Withdrawn
DexmedetomidineThe therapeutic efficacy of Dexmedetomidine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
DexmethylphenidateThe therapeutic efficacy of Dexmethylphenidate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DexniguldipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Dexniguldipine is combined with Magnesium sulfate.Experimental
DextofisopamThe therapeutic efficacy of Dextofisopam can be increased when used in combination with Magnesium sulfate.Investigational
DextromethorphanThe therapeutic efficacy of Dextromethorphan can be increased when used in combination with Magnesium sulfate.Approved
DextromoramideThe therapeutic efficacy of Dextromoramide can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DextropropoxypheneThe therapeutic efficacy of Dextropropoxyphene can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Withdrawn
DexverapamilThe risk or severity of hypotension and neuromuscular blockade can be increased when Dexverapamil is combined with Magnesium sulfate.Experimental
DezocineThe therapeutic efficacy of Dezocine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DiazepamThe therapeutic efficacy of Diazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
DibekacinThe therapeutic efficacy of Dibekacin can be increased when used in combination with Magnesium sulfate.Experimental
DibenzepinThe therapeutic efficacy of Dibenzepin can be increased when used in combination with Magnesium sulfate.Experimental
DichloralphenazoneThe therapeutic efficacy of Dichloralphenazone can be increased when used in combination with Magnesium sulfate.Approved, Illicit
DiclofenamideThe risk or severity of adverse effects can be increased when Diclofenamide is combined with Magnesium sulfate.Approved, Investigational
DicyclomineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Dicyclomine.Approved
Diethyl etherThe therapeutic efficacy of Diethyl ether can be increased when used in combination with Magnesium sulfate.Experimental
DifemerineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Difemerine.Experimental
DifenoxinThe therapeutic efficacy of Difenoxin can be increased when used in combination with Magnesium sulfate.Approved, Illicit
DifloxacinMagnesium sulfate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Vet Approved
DihexyverineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Dihexyverine.Experimental
DihydrocodeineThe therapeutic efficacy of Dihydrocodeine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
DihydroergotamineThe therapeutic efficacy of Dihydroergotamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DihydroetorphineThe therapeutic efficacy of Dihydroetorphine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DihydromorphineThe therapeutic efficacy of Dihydromorphine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DihydrostreptomycinThe therapeutic efficacy of Dihydrostreptomycin can be increased when used in combination with Magnesium sulfate.Investigational, Vet Approved
DiltiazemThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium sulfate.Approved, Investigational
DimenhydrinateThe therapeutic efficacy of Dimenhydrinate can be increased when used in combination with Magnesium sulfate.Approved
DimetacrineThe therapeutic efficacy of Dimetacrine can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
DimethyltryptamineThe therapeutic efficacy of Dimethyltryptamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DimetindeneThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Dimetindene.Approved, Investigational
DiphemanilThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Diphemanil.Experimental
Diphemanil MethylsulfateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Diphemanil Methylsulfate.Approved, Vet Approved, Withdrawn
DiphenhydramineThe therapeutic efficacy of Diphenhydramine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DiphenidolThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Diphenidol.Approved, Investigational, Withdrawn
DiphenoxylateThe therapeutic efficacy of Diphenoxylate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
Dipotassium phosphateThe serum concentration of Dipotassium phosphate can be decreased when it is combined with Magnesium sulfate.Approved
DisopyramideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Disopyramide.Approved
DixyrazineThe therapeutic efficacy of Dixyrazine can be increased when used in combination with Magnesium sulfate.Experimental
DocusateThe therapeutic efficacy of Docusate can be decreased when used in combination with Magnesium sulfate.Approved
DolasetronThe therapeutic efficacy of Dolasetron can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Magnesium sulfate.Approved
Domoic AcidThe therapeutic efficacy of Domoic Acid can be increased when used in combination with Magnesium sulfate.Experimental
DonepezilThe therapeutic efficacy of Donepezil can be increased when used in combination with Magnesium sulfate.Approved
DoramectinThe therapeutic efficacy of Doramectin can be increased when used in combination with Magnesium sulfate.Vet Approved
DorzolamideThe risk or severity of adverse effects can be increased when Dorzolamide is combined with Magnesium sulfate.Approved
DosulepinThe therapeutic efficacy of Dosulepin can be increased when used in combination with Magnesium sulfate.Approved
DotarizineThe therapeutic efficacy of Dotarizine can be increased when used in combination with Magnesium sulfate.Investigational
DoxacuriumThe therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium sulfate.Approved
DoxazosinThe risk or severity of hypotension can be increased when Doxazosin is combined with Magnesium sulfate.Approved
DoxefazepamThe therapeutic efficacy of Doxefazepam can be increased when used in combination with Magnesium sulfate.Experimental
DoxepinThe therapeutic efficacy of Doxepin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
DoxofyllineMagnesium sulfate may increase the excretion rate of Doxofylline which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
DoxycyclineThe therapeutic efficacy of Doxycycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Vet Approved
DPDPEThe therapeutic efficacy of DPDPE can be increased when used in combination with Magnesium sulfate.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Illicit
DronedaroneThe risk or severity of hypotension can be increased when Dronedarone is combined with Magnesium sulfate.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Drospirenone is combined with Magnesium sulfate.Approved
DrotebanolThe therapeutic efficacy of Drotebanol can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
DuloxetineThe therapeutic efficacy of Duloxetine can be increased when used in combination with Magnesium sulfate.Approved
DyclonineThe therapeutic efficacy of Dyclonine can be increased when used in combination with Magnesium sulfate.Approved
EconazoleThe therapeutic efficacy of Econazole can be increased when used in combination with Magnesium sulfate.Approved
EcopipamThe therapeutic efficacy of Ecopipam can be increased when used in combination with Magnesium sulfate.Investigational
EdivoxetineThe therapeutic efficacy of Edivoxetine can be increased when used in combination with Magnesium sulfate.Investigational
EfavirenzThe therapeutic efficacy of Efavirenz can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EfinaconazoleThe therapeutic efficacy of Efinaconazole can be increased when used in combination with Magnesium sulfate.Approved
EfonidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Efonidipine is combined with Magnesium sulfate.Approved, Investigational
EletriptanThe therapeutic efficacy of Eletriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EltanoloneThe therapeutic efficacy of Eltanolone can be increased when used in combination with Magnesium sulfate.Investigational
EltoprazineThe therapeutic efficacy of Eltoprazine can be increased when used in combination with Magnesium sulfate.Investigational
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Magnesium sulfate.Approved
EluxadolineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Eluxadoline.Approved, Investigational
EmeproniumThe therapeutic efficacy of Emepronium can be increased when used in combination with Magnesium sulfate.Experimental
EmopamilThe risk or severity of hypotension and neuromuscular blockade can be increased when Emopamil is combined with Magnesium sulfate.Experimental
EmpagliflozinThe risk or severity of adverse effects can be increased when Empagliflozin is combined with Magnesium sulfate.Approved
EmylcamateThe therapeutic efficacy of Emylcamate can be increased when used in combination with Magnesium sulfate.Experimental
EnfluraneThe therapeutic efficacy of Enflurane can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
EnoxacinMagnesium sulfate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
EntacaponeThe therapeutic efficacy of Entacapone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EntecavirMagnesium sulfate may increase the excretion rate of Entecavir which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
EnzalutamideThe serum concentration of Magnesium sulfate can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe therapeutic efficacy of Eperisone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EpinastineThe therapeutic efficacy of Epinastine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EpitizideThe risk or severity of adverse effects can be increased when Epitizide is combined with Magnesium sulfate.Experimental
EplerenoneThe risk or severity of adverse effects can be increased when Eplerenone is combined with Magnesium sulfate.Approved
EplivanserinThe therapeutic efficacy of Eplivanserin can be increased when used in combination with Magnesium sulfate.Investigational
Ergoloid mesylateThe therapeutic efficacy of Ergoloid mesylate can be increased when used in combination with Magnesium sulfate.Approved
ErgonovineThe therapeutic efficacy of Ergonovine can be increased when used in combination with Magnesium sulfate.Approved
ErgotamineThe therapeutic efficacy of Ergotamine can be increased when used in combination with Magnesium sulfate.Approved
ErtugliflozinThe risk or severity of adverse effects can be increased when Ertugliflozin is combined with Magnesium sulfate.Approved, Investigational
ErythromycinThe metabolism of Magnesium sulfate can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EscitalopramThe therapeutic efficacy of Escitalopram can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Eslicarbazepine acetateThe therapeutic efficacy of Eslicarbazepine acetate can be increased when used in combination with Magnesium sulfate.Approved
EsmirtazapineThe therapeutic efficacy of Esmirtazapine can be increased when used in combination with Magnesium sulfate.Investigational
EsreboxetineThe therapeutic efficacy of Esreboxetine can be increased when used in combination with Magnesium sulfate.Investigational
EstazolamThe therapeutic efficacy of Estazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
EszopicloneThe therapeutic efficacy of Eszopiclone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be increased when used in combination with Magnesium sulfate.Approved, Investigational
EtamiphyllineMagnesium sulfate may increase the excretion rate of Etamiphylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
EtanautineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Etanautine.Experimental
EthadioneThe therapeutic efficacy of Ethadione can be increased when used in combination with Magnesium sulfate.Experimental
EthanolMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe therapeutic efficacy of Ethchlorvynol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
EthopropazineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Ethopropazine.Approved
EthosuximideThe therapeutic efficacy of Ethosuximide can be increased when used in combination with Magnesium sulfate.Approved
EthotoinThe therapeutic efficacy of Ethotoin can be increased when used in combination with Magnesium sulfate.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Magnesium sulfate.Withdrawn
Ethyl carbamateThe therapeutic efficacy of Ethyl carbamate can be increased when used in combination with Magnesium sulfate.Withdrawn
Ethyl chlorideThe therapeutic efficacy of Ethyl chloride can be increased when used in combination with Magnesium sulfate.Approved, Experimental, Investigational
Ethyl loflazepateThe therapeutic efficacy of Ethyl loflazepate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
EthylmorphineThe therapeutic efficacy of Ethylmorphine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Magnesium sulfate.Approved
EtifoxineThe therapeutic efficacy of Etifoxine can be increased when used in combination with Magnesium sulfate.Investigational, Withdrawn
EtiracetamThe therapeutic efficacy of Etiracetam can be increased when used in combination with Magnesium sulfate.Investigational
EtizolamThe therapeutic efficacy of Etizolam can be increased when used in combination with Magnesium sulfate.Approved
EtomidateThe therapeutic efficacy of Etomidate can be increased when used in combination with Magnesium sulfate.Approved
EtoperidoneThe therapeutic efficacy of Etoperidone can be increased when used in combination with Magnesium sulfate.Withdrawn
EtorphineThe therapeutic efficacy of Etorphine can be increased when used in combination with Magnesium sulfate.Illicit, Vet Approved
EtravirineThe serum concentration of Magnesium sulfate can be decreased when it is combined with Etravirine.Approved
EtybenzatropineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Etybenzatropine.Experimental
EzogabineThe therapeutic efficacy of Ezogabine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FabomotizoleThe therapeutic efficacy of Fabomotizole can be increased when used in combination with Magnesium sulfate.Experimental
Fazadinium bromideThe therapeutic efficacy of Fazadinium bromide can be increased when used in combination with Magnesium sulfate.Experimental
FebarbamateThe therapeutic efficacy of Febarbamate can be increased when used in combination with Magnesium sulfate.Experimental
FelbamateThe therapeutic efficacy of Felbamate can be increased when used in combination with Magnesium sulfate.Approved
FelodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Felodipine is combined with Magnesium sulfate.Approved, Investigational
FencamfamineThe therapeutic efficacy of Fencamfamine can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
FendilineThe risk or severity of hypotension and neuromuscular blockade can be increased when Fendiline is combined with Magnesium sulfate.Withdrawn
FenethyllineMagnesium sulfate may increase the excretion rate of Fenethylline which could result in a lower serum level and potentially a reduction in efficacy.Approved
FenfluramineThe therapeutic efficacy of Fenfluramine can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Withdrawn
FenpiveriniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Fenpiverinium.Experimental
FenquizoneThe risk or severity of adverse effects can be increased when Fenquizone is combined with Magnesium sulfate.Experimental
FentanylThe therapeutic efficacy of Fentanyl can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Vet Approved
FenticonazoleThe therapeutic efficacy of Fenticonazole can be increased when used in combination with Magnesium sulfate.Experimental
FenyramidolThe therapeutic efficacy of Fenyramidol can be increased when used in combination with Magnesium sulfate.Experimental
Ferric pyrophosphateThe serum concentration of Ferric pyrophosphate can be decreased when it is combined with Magnesium sulfate.Experimental
Ferric pyrophosphate citrateThe serum concentration of Ferric pyrophosphate citrate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
FesoterodineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Fesoterodine.Approved
FexofenadineThe therapeutic efficacy of Fexofenadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Fish oilThe risk or severity of hypotension and neuromuscular blockade can be increased when Fish oil is combined with Magnesium sulfate.Approved, Nutraceutical
FlavoxateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Flavoxate.Approved
FleroxacinMagnesium sulfate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FlibanserinThe therapeutic efficacy of Flibanserin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FluanisoneThe therapeutic efficacy of Fluanisone can be increased when used in combination with Magnesium sulfate.Experimental
FluconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Fluconazole.Approved, Investigational
FludiazepamThe therapeutic efficacy of Fludiazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
FlumequineMagnesium sulfate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be increased when used in combination with Magnesium sulfate.Approved
FlunitrazepamThe therapeutic efficacy of Flunitrazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
FluoxetineThe therapeutic efficacy of Fluoxetine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
FlupentixolThe therapeutic efficacy of Flupentixol can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
FluphenazineThe therapeutic efficacy of Fluphenazine can be increased when used in combination with Magnesium sulfate.Approved
FlurazepamThe therapeutic efficacy of Flurazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
FluspirileneThe therapeutic efficacy of Fluspirilene can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Fluticasone propionateThe therapeutic efficacy of Fluticasone propionate can be increased when used in combination with Magnesium sulfate.Approved
FlutrimazoleThe therapeutic efficacy of Flutrimazole can be increased when used in combination with Magnesium sulfate.Experimental
FluvoxamineThe therapeutic efficacy of Fluvoxamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FosamprenavirThe metabolism of Magnesium sulfate can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Magnesium sulfate can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe therapeutic efficacy of Fosphenytoin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FospropofolThe therapeutic efficacy of Fospropofol can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
FramycetinThe therapeutic efficacy of Framycetin can be increased when used in combination with Magnesium sulfate.Approved
FrovatriptanThe therapeutic efficacy of Frovatriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
FurafyllineMagnesium sulfate may increase the excretion rate of Furafylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
FurazolidoneThe therapeutic efficacy of Furazolidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Magnesium sulfate.Approved, Vet Approved
Fusidic AcidThe serum concentration of Magnesium sulfate can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe therapeutic efficacy of Gabapentin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Gabapentin EnacarbilThe therapeutic efficacy of Gabapentin Enacarbil can be increased when used in combination with Magnesium sulfate.Approved, Investigational
GaboxadolThe therapeutic efficacy of Gaboxadol can be increased when used in combination with Magnesium sulfate.Investigational
GallamineThe therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium sulfate.Experimental
Gallamine TriethiodideThe therapeutic efficacy of Gallamine Triethiodide can be increased when used in combination with Magnesium sulfate.Approved
GallopamilThe risk or severity of hypotension and neuromuscular blockade can be increased when Gallopamil is combined with Magnesium sulfate.Investigational
Gamma Hydroxybutyric AcidThe therapeutic efficacy of Gamma Hydroxybutyric Acid can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
GanciclovirMagnesium sulfate may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
Gantacurium ChlorideThe therapeutic efficacy of Gantacurium Chloride can be increased when used in combination with Magnesium sulfate.Investigational
GarenoxacinMagnesium sulfate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
GatifloxacinMagnesium sulfate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GedocarnilThe therapeutic efficacy of Gedocarnil can be increased when used in combination with Magnesium sulfate.Experimental
GemifloxacinMagnesium sulfate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GeneticinThe therapeutic efficacy of Geneticin can be increased when used in combination with Magnesium sulfate.Experimental
GentamicinThe therapeutic efficacy of Gentamicin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
GENTAMICIN C1AThe therapeutic efficacy of GENTAMICIN C1A can be increased when used in combination with Magnesium sulfate.Experimental
GepironeThe therapeutic efficacy of Gepirone can be increased when used in combination with Magnesium sulfate.Investigational
Geranyl DiphosphateThe serum concentration of Geranyl Diphosphate can be decreased when it is combined with Magnesium sulfate.Experimental
Geranylgeranyl diphosphateThe serum concentration of Geranylgeranyl diphosphate can be decreased when it is combined with Magnesium sulfate.Experimental
GlutethimideThe therapeutic efficacy of Glutethimide can be increased when used in combination with Magnesium sulfate.Approved, Illicit
GlycerinThe therapeutic efficacy of Glycerin can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
GlycopyrroniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Glycopyrronium.Approved, Investigational, Vet Approved
GranisetronThe therapeutic efficacy of Granisetron can be increased when used in combination with Magnesium sulfate.Approved, Investigational
GrepafloxacinMagnesium sulfate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
GuanfacineThe therapeutic efficacy of Guanfacine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
GuanineMagnesium sulfate may increase the excretion rate of Guanine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
HalazepamThe therapeutic efficacy of Halazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
HaloperidolThe therapeutic efficacy of Haloperidol can be increased when used in combination with Magnesium sulfate.Approved
HalothaneThe therapeutic efficacy of Halothane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
HarmalineThe therapeutic efficacy of Harmaline can be increased when used in combination with Magnesium sulfate.Experimental
HeptabarbitalThe therapeutic efficacy of Heptabarbital can be increased when used in combination with Magnesium sulfate.Approved
HeroinThe therapeutic efficacy of Heroin can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
HexafluroniumThe therapeutic efficacy of Hexafluronium can be increased when used in combination with Magnesium sulfate.Approved
HexamethoniumThe therapeutic efficacy of Hexamethonium can be increased when used in combination with Magnesium sulfate.Experimental
HexapropymateThe therapeutic efficacy of Hexapropymate can be increased when used in combination with Magnesium sulfate.Experimental
HexobarbitalThe therapeutic efficacy of Hexobarbital can be increased when used in combination with Magnesium sulfate.Approved
HexocycliumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Hexocyclium.Approved
HomatropineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Homatropine.Approved
Homatropine MethylbromideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Homatropine Methylbromide.Approved
HydracarbazineThe therapeutic efficacy of Hydracarbazine can be increased when used in combination with Magnesium sulfate.Experimental
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Magnesium sulfate.Approved, Vet Approved
HydrocodoneMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Hydroflumethiazide is combined with Magnesium sulfate.Approved, Investigational
HydromorphoneThe therapeutic efficacy of Hydromorphone can be increased when used in combination with Magnesium sulfate.Approved, Illicit
HydrotalciteThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Hydrotalcite.Approved, Experimental, Investigational
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.Approved
Hygromycin BThe therapeutic efficacy of Hygromycin B can be increased when used in combination with Magnesium sulfate.Vet Approved
HyoscyamineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Hyoscyamine.Approved
HypericinThe therapeutic efficacy of Hypericin can be increased when used in combination with Magnesium sulfate.Investigational
HypoxanthineMagnesium sulfate may increase the excretion rate of Hypoxanthine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
IbopamineThe risk or severity of adverse effects can be increased when Ibopamine is combined with Magnesium sulfate.Experimental
IdalopirdineThe therapeutic efficacy of Idalopirdine can be increased when used in combination with Magnesium sulfate.Investigational
IdelalisibThe metabolism of Magnesium sulfate can be decreased when combined with Idelalisib.Approved
IfenprodilThe therapeutic efficacy of Ifenprodil can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
IferanserinThe therapeutic efficacy of Iferanserin can be increased when used in combination with Magnesium sulfate.Investigational
IloperidoneThe therapeutic efficacy of Iloperidone can be increased when used in combination with Magnesium sulfate.Approved
ImagabalinThe therapeutic efficacy of Imagabalin can be increased when used in combination with Magnesium sulfate.Investigational
ImatinibThe metabolism of Magnesium sulfate can be decreased when combined with Imatinib.Approved
ImidafenacinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Imidafenacin.Approved, Investigational
ImipramineThe therapeutic efficacy of Imipramine can be increased when used in combination with Magnesium sulfate.Approved
Imipramine oxideThe therapeutic efficacy of Imipramine oxide can be increased when used in combination with Magnesium sulfate.Experimental
Incadronic acidThe serum concentration of Incadronic acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
IndalpineThe therapeutic efficacy of Indalpine can be increased when used in combination with Magnesium sulfate.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Indapamide is combined with Magnesium sulfate.Approved
IndinavirThe metabolism of Magnesium sulfate can be decreased when combined with Indinavir.Approved
IndiplonThe therapeutic efficacy of Indiplon can be increased when used in combination with Magnesium sulfate.Investigational
IndoraminThe risk or severity of hypotension can be increased when Indoramin is combined with Magnesium sulfate.Withdrawn
IpratropiumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Ipratropium.Approved
IprazochromeThe therapeutic efficacy of Iprazochrome can be increased when used in combination with Magnesium sulfate.Experimental
IprindoleThe therapeutic efficacy of Iprindole can be increased when used in combination with Magnesium sulfate.Experimental
IproclozideThe therapeutic efficacy of Iproclozide can be increased when used in combination with Magnesium sulfate.Withdrawn
IproniazidThe therapeutic efficacy of Iproniazid can be increased when used in combination with Magnesium sulfate.Withdrawn
IsavuconazoleThe serum concentration of Magnesium sulfate can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Magnesium sulfate can be decreased when combined with Isavuconazonium.Approved, Investigational
IsepamicinThe therapeutic efficacy of Isepamicin can be increased when used in combination with Magnesium sulfate.Experimental
IsocarboxazidThe therapeutic efficacy of Isocarboxazid can be increased when used in combination with Magnesium sulfate.Approved
IsoconazoleThe therapeutic efficacy of Isoconazole can be increased when used in combination with Magnesium sulfate.Approved
IsofluraneThe therapeutic efficacy of Isoflurane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
IsoniazidThe metabolism of Magnesium sulfate can be decreased when combined with Isoniazid.Approved, Investigational
IsopropamideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Isopropamide.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Isosorbide is combined with Magnesium sulfate.Approved, Investigational
IsradipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Isradipine is combined with Magnesium sulfate.Approved, Investigational
ItraconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Magnesium sulfate can be increased when it is combined with Ivacaftor.Approved
KanamycinThe therapeutic efficacy of Kanamycin can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
KetamineThe therapeutic efficacy of Ketamine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
KetanserinThe therapeutic efficacy of Ketanserin can be increased when used in combination with Magnesium sulfate.Investigational
KetazolamThe therapeutic efficacy of Ketazolam can be increased when used in combination with Magnesium sulfate.Approved
KetobemidoneThe therapeutic efficacy of Ketobemidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
KetoconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Ketoconazole.Approved, Investigational
L-TryptophanThe therapeutic efficacy of L-Tryptophan can be increased when used in combination with Magnesium sulfate.Approved, Nutraceutical, Withdrawn
LabetalolThe risk or severity of hypotension can be increased when Labetalol is combined with Magnesium sulfate.Approved
LacidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lacidipine is combined with Magnesium sulfate.Approved, Investigational
LacosamideThe therapeutic efficacy of Lacosamide can be increased when used in combination with Magnesium sulfate.Approved
LactitolThe therapeutic efficacy of Lactitol can be decreased when used in combination with Magnesium sulfate.Investigational
LactuloseThe therapeutic efficacy of Lactulose can be decreased when used in combination with Magnesium sulfate.Approved
LamotrigineThe therapeutic efficacy of Lamotrigine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LanicemineThe therapeutic efficacy of Lanicemine can be increased when used in combination with Magnesium sulfate.Investigational
LasmiditanThe therapeutic efficacy of Lasmiditan can be increased when used in combination with Magnesium sulfate.Investigational
LercanidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lercanidipine is combined with Magnesium sulfate.Approved, Investigational
LevetiracetamThe therapeutic efficacy of Levetiracetam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevocabastineThe therapeutic efficacy of Levocabastine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevocetirizineThe therapeutic efficacy of Levocetirizine can be increased when used in combination with Magnesium sulfate.Approved
LevodopaThe therapeutic efficacy of Levodopa can be increased when used in combination with Magnesium sulfate.Approved
LevofloxacinMagnesium sulfate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Levomethadyl AcetateThe therapeutic efficacy of Levomethadyl Acetate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevomilnacipranThe therapeutic efficacy of Levomilnacipran can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LevorphanolThe therapeutic efficacy of Levorphanol can be increased when used in combination with Magnesium sulfate.Approved
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium sulfate.Approved
LidoflazineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lidoflazine is combined with Magnesium sulfate.Experimental
LinaclotideThe therapeutic efficacy of Linaclotide can be decreased when used in combination with Magnesium sulfate.Approved
LincomycinThe therapeutic efficacy of Lincomycin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
LinezolidThe therapeutic efficacy of Linezolid can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Lipoic AcidMagnesium sulfate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Nutraceutical
LisofyllineMagnesium sulfate may increase the excretion rate of Lisofylline which could result in a lower serum level and potentially a reduction in efficacy.Investigational
LisurideThe therapeutic efficacy of Lisuride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Lithium carbonateThe therapeutic efficacy of Lithium carbonate can be increased when used in combination with Magnesium sulfate.Approved
Lithium cationThe therapeutic efficacy of Lithium cation can be increased when used in combination with Magnesium sulfate.Experimental
LobucavirMagnesium sulfate may increase the excretion rate of Lobucavir which could result in a lower serum level and potentially a reduction in efficacy.Investigational
LofentanilThe therapeutic efficacy of Lofentanil can be increased when used in combination with Magnesium sulfate.Illicit
LofepramineThe therapeutic efficacy of Lofepramine can be increased when used in combination with Magnesium sulfate.Experimental
LofexidineThe therapeutic efficacy of Lofexidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LomefloxacinMagnesium sulfate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LomerizineThe risk or severity of hypotension and neuromuscular blockade can be increased when Lomerizine is combined with Magnesium sulfate.Experimental
LoperamideThe risk or severity of hypotension and neuromuscular blockade can be increased when Loperamide is combined with Magnesium sulfate.Approved
LopinavirThe metabolism of Magnesium sulfate can be decreased when combined with Lopinavir.Approved
LoprazolamThe therapeutic efficacy of Loprazolam can be increased when used in combination with Magnesium sulfate.Experimental
LoratadineThe therapeutic efficacy of Loratadine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LorazepamThe therapeutic efficacy of Lorazepam can be increased when used in combination with Magnesium sulfate.Approved
LorcaserinThe therapeutic efficacy of Lorcaserin can be increased when used in combination with Magnesium sulfate.Approved
LormetazepamThe therapeutic efficacy of Lormetazepam can be increased when used in combination with Magnesium sulfate.Approved
LorpiprazoleThe serum concentration of Magnesium sulfate can be increased when it is combined with Lorpiprazole.Approved
LortalamineThe therapeutic efficacy of Lortalamine can be increased when used in combination with Magnesium sulfate.Experimental
LovastatinThe metabolism of Magnesium sulfate can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe therapeutic efficacy of Loxapine can be increased when used in combination with Magnesium sulfate.Approved
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
LuliconazoleThe serum concentration of Magnesium sulfate can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Magnesium sulfate can be increased when combined with Lumacaftor.Approved
LumateperoneThe therapeutic efficacy of Lumateperone can be increased when used in combination with Magnesium sulfate.Investigational
LurasidoneThe therapeutic efficacy of Lurasidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
LymecyclineThe therapeutic efficacy of Lymecycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Lysergic Acid DiethylamideThe therapeutic efficacy of Lysergic Acid Diethylamide can be increased when used in combination with Magnesium sulfate.Illicit, Investigational, Withdrawn
m-ChlorophenylpiperazineThe therapeutic efficacy of m-Chlorophenylpiperazine can be increased when used in combination with Magnesium sulfate.Investigational
MagaldrateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Magaldrate.Approved, Withdrawn
Magnesium acetateThe therapeutic efficacy of Magnesium acetate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium acetate tetrahydrateThe therapeutic efficacy of Magnesium acetate tetrahydrate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium Aluminum SilicateThe therapeutic efficacy of Magnesium Aluminum Silicate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium aspartateThe therapeutic efficacy of Magnesium aspartate can be increased when used in combination with Magnesium sulfate.Experimental
Magnesium carbonateThe therapeutic efficacy of Magnesium carbonate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Magnesium cationThe therapeutic efficacy of Magnesium cation can be increased when used in combination with Magnesium sulfate.Approved, Nutraceutical
Magnesium chlorideThe therapeutic efficacy of Magnesium chloride can be increased when used in combination with Magnesium sulfate.Approved
Magnesium citrateThe therapeutic efficacy of Magnesium citrate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium gluconateThe therapeutic efficacy of Magnesium gluconate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Magnesium glycinateThe therapeutic efficacy of Magnesium glycinate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium hydroxideThe therapeutic efficacy of Magnesium hydroxide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Magnesium orotateThe therapeutic efficacy of Magnesium orotate can be increased when used in combination with Magnesium sulfate.Experimental
Magnesium oxideThe therapeutic efficacy of Magnesium oxide can be increased when used in combination with Magnesium sulfate.Approved
Magnesium peroxideThe therapeutic efficacy of Magnesium peroxide can be decreased when used in combination with Magnesium sulfate.Experimental
Magnesium phosphateThe therapeutic efficacy of Magnesium phosphate can be increased when used in combination with Magnesium sulfate.Experimental
Magnesium salicylateThe risk or severity of hypotension and neuromuscular blockade can be increased when Magnesium sulfate is combined with Magnesium salicylate.Approved
Magnesium silicateThe therapeutic efficacy of Magnesium silicate can be increased when used in combination with Magnesium sulfate.Approved
Magnesium stearateThe therapeutic efficacy of Magnesium stearate can be increased when used in combination with Magnesium sulfate.Investigational
Magnesium TrisilicateThe therapeutic efficacy of Magnesium Trisilicate can be increased when used in combination with Magnesium sulfate.Approved
ManidipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Manidipine is combined with Magnesium sulfate.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Mannitol is combined with Magnesium sulfate.Approved, Investigational
MaprotilineThe therapeutic efficacy of Maprotiline can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MazaticolThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mazaticol.Experimental
MazindolThe therapeutic efficacy of Mazindol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MebanazineThe therapeutic efficacy of Mebanazine can be increased when used in combination with Magnesium sulfate.Withdrawn
MebeverineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mebeverine.Approved, Investigational
MebicarThe therapeutic efficacy of Mebicar can be increased when used in combination with Magnesium sulfate.Experimental
MebutamateThe therapeutic efficacy of Mebutamate can be increased when used in combination with Magnesium sulfate.Approved
MebutizideThe risk or severity of adverse effects can be increased when Mebutizide is combined with Magnesium sulfate.Experimental
MecamylamineThe therapeutic efficacy of Mecamylamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MeclizineThe therapeutic efficacy of Meclizine can be increased when used in combination with Magnesium sulfate.Approved
MedazepamThe therapeutic efficacy of Medazepam can be increased when used in combination with Magnesium sulfate.Experimental
MedetomidineThe therapeutic efficacy of Medetomidine can be increased when used in combination with Magnesium sulfate.Vet Approved
MedifoxamineThe therapeutic efficacy of Medifoxamine can be increased when used in combination with Magnesium sulfate.Experimental
MefloquineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mefloquine.Approved, Investigational
MefrusideThe risk or severity of adverse effects can be increased when Mefruside is combined with Magnesium sulfate.Experimental
MelatoninThe therapeutic efficacy of Melatonin can be increased when used in combination with Magnesium sulfate.Approved, Nutraceutical, Vet Approved
MelitracenThe therapeutic efficacy of Melitracen can be increased when used in combination with Magnesium sulfate.Experimental, Investigational
MelperoneThe therapeutic efficacy of Melperone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MentholThe risk or severity of hypotension and neuromuscular blockade can be increased when Menthol is combined with Magnesium sulfate.Approved
MepenzolateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Mepenzolate.Approved
MephenesinThe therapeutic efficacy of Mephenesin can be increased when used in combination with Magnesium sulfate.Approved
MephenoxaloneThe therapeutic efficacy of Mephenoxalone can be increased when used in combination with Magnesium sulfate.Experimental
MephenytoinThe therapeutic efficacy of Mephenytoin can be increased when used in combination with Magnesium sulfate.Investigational, Withdrawn
MeprobamateThe therapeutic efficacy of Meprobamate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MeptazinolThe therapeutic efficacy of Meptazinol can be increased when used in combination with Magnesium sulfate.Experimental
MersalylThe risk or severity of adverse effects can be increased when Mersalyl is combined with Magnesium sulfate.Approved
MesoridazineThe therapeutic efficacy of Mesoridazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MetaxaloneThe therapeutic efficacy of Metaxalone can be increased when used in combination with Magnesium sulfate.Approved
MetergolineThe therapeutic efficacy of Metergoline can be increased when used in combination with Magnesium sulfate.Experimental
MethacyclineThe therapeutic efficacy of Methacycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MethadoneThe therapeutic efficacy of Methadone can be increased when used in combination with Magnesium sulfate.Approved
Methadyl AcetateThe therapeutic efficacy of Methadyl Acetate can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MethamphetamineThe therapeutic efficacy of Methamphetamine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MethanthelineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Methantheline.Approved, Investigational
MethapyrileneThe therapeutic efficacy of Methapyrilene can be increased when used in combination with Magnesium sulfate.Withdrawn
MethaqualoneThe therapeutic efficacy of Methaqualone can be increased when used in combination with Magnesium sulfate.Illicit, Withdrawn
MetharbitalThe therapeutic efficacy of Metharbital can be increased when used in combination with Magnesium sulfate.Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Magnesium sulfate.Approved
MethocarbamolThe therapeutic efficacy of Methocarbamol can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
MethohexitalThe therapeutic efficacy of Methohexital can be increased when used in combination with Magnesium sulfate.Approved
MethotrimeprazineMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe therapeutic efficacy of Methoxyflurane can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
MethscopolamineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Methscopolamine.Approved
MethsuximideThe therapeutic efficacy of Methsuximide can be increased when used in combination with Magnesium sulfate.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Magnesium sulfate.Approved
Methyl celluloseThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Magnesium sulfate.Approved
Methylene blueThe therapeutic efficacy of Methylene blue can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MethylpentynolThe therapeutic efficacy of Methylpentynol can be increased when used in combination with Magnesium sulfate.Experimental
MethylphenidateThe therapeutic efficacy of Methylphenidate can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MethylphenobarbitalThe therapeutic efficacy of Methylphenobarbital can be increased when used in combination with Magnesium sulfate.Approved
Methylscopolamine bromideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Methylscopolamine bromide.Approved
MethyprylonThe therapeutic efficacy of Methyprylon can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Withdrawn
MethysergideThe therapeutic efficacy of Methysergide can be increased when used in combination with Magnesium sulfate.Approved
MeticraneThe risk or severity of adverse effects can be increased when Meticrane is combined with Magnesium sulfate.Experimental
MetixeneThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Metixene.Approved
MetocurineThe therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium sulfate.Approved
Metocurine IodideThe therapeutic efficacy of Metocurine Iodide can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
MetolazoneThe risk or severity of adverse effects can be increased when Metolazone is combined with Magnesium sulfate.Approved
MetyrosineMagnesium sulfate may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of Mianserin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MibefradilThe risk or severity of hypotension and neuromuscular blockade can be increased when Mibefradil is combined with Magnesium sulfate.Investigational, Withdrawn
MiconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MicronomicinThe therapeutic efficacy of Micronomicin can be increased when used in combination with Magnesium sulfate.Experimental
MidazolamThe therapeutic efficacy of Midazolam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
MidomafetamineThe therapeutic efficacy of Midomafetamine can be increased when used in combination with Magnesium sulfate.Experimental, Illicit, Investigational
MifepristoneThe serum concentration of Magnesium sulfate can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe therapeutic efficacy of Milnacipran can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MinaprineThe therapeutic efficacy of Minaprine can be increased when used in combination with Magnesium sulfate.Approved
Mineral oilThe therapeutic efficacy of Mineral oil can be decreased when used in combination with Magnesium sulfate.Approved, Vet Approved
MinocyclineThe therapeutic efficacy of Minocycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MirtazapineThe therapeutic efficacy of Mirtazapine can be increased when used in combination with Magnesium sulfate.Approved
MitotaneThe serum concentration of Magnesium sulfate can be decreased when it is combined with Mitotane.Approved
MivacuriumThe therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium sulfate.Approved
MK-212The therapeutic efficacy of MK-212 can be increased when used in combination with Magnesium sulfate.Investigational
MMDAThe therapeutic efficacy of MMDA can be increased when used in combination with Magnesium sulfate.Experimental, Illicit
MoclobemideThe therapeutic efficacy of Moclobemide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ModafinilThe serum concentration of Magnesium sulfate can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe therapeutic efficacy of Molindone can be increased when used in combination with Magnesium sulfate.Approved
Monopotassium phosphateThe serum concentration of Monopotassium phosphate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
MoperoneThe therapeutic efficacy of Moperone can be increased when used in combination with Magnesium sulfate.Experimental
MoricizineThe therapeutic efficacy of Moricizine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
MorphineThe therapeutic efficacy of Morphine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
MosapramineThe therapeutic efficacy of Mosapramine can be increased when used in combination with Magnesium sulfate.Experimental
MosaprideThe therapeutic efficacy of Mosapride can be increased when used in combination with Magnesium sulfate.Investigational
MoxifloxacinMagnesium sulfate can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
MRK-409The therapeutic efficacy of MRK-409 can be increased when used in combination with Magnesium sulfate.Experimental
MuzolimineThe risk or severity of adverse effects can be increased when Muzolimine is combined with Magnesium sulfate.Experimental
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium sulfate.Approved
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamineThe therapeutic efficacy of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine can be increased when used in combination with Magnesium sulfate.Experimental
NabiloneThe therapeutic efficacy of Nabilone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
NafcillinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Nafcillin.Approved, Investigational
NaftidrofurylThe therapeutic efficacy of Naftidrofuryl can be increased when used in combination with Magnesium sulfate.Experimental
NaftopidilThe risk or severity of hypotension and neuromuscular blockade can be increased when Naftopidil is combined with Magnesium sulfate.Investigational
NalbuphineThe therapeutic efficacy of Nalbuphine can be increased when used in combination with Magnesium sulfate.Approved
Nalidixic AcidMagnesium sulfate can cause a decrease in the absorption of Nalidixic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
NaloxoneThe metabolism of Magnesium sulfate can be decreased when combined with Naloxone.Approved, Vet Approved
NaltrexoneThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NaluzotanThe therapeutic efficacy of Naluzotan can be increased when used in combination with Magnesium sulfate.Investigational
NaratriptanThe therapeutic efficacy of Naratriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
NaronaprideThe therapeutic efficacy of Naronapride can be increased when used in combination with Magnesium sulfate.Investigational
NeamineThe therapeutic efficacy of Neamine can be increased when used in combination with Magnesium sulfate.Experimental
NefazodoneThe therapeutic efficacy of Nefazodone can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
NefiracetamThe therapeutic efficacy of Nefiracetam can be increased when used in combination with Magnesium sulfate.Investigational
NelfinavirThe metabolism of Magnesium sulfate can be decreased when combined with Nelfinavir.Approved
NemonoxacinMagnesium sulfate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
NeocitrullamonThe therapeutic efficacy of Neocitrullamon can be increased when used in combination with Magnesium sulfate.Experimental
NeomycinThe therapeutic efficacy of Neomycin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
NeosaxitoxinThe therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium sulfate.Investigational
NetilmicinThe therapeutic efficacy of Netilmicin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
NetupitantThe serum concentration of Magnesium sulfate can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Magnesium sulfate can be increased when combined with Nevirapine.Approved
NialamideThe therapeutic efficacy of Nialamide can be increased when used in combination with Magnesium sulfate.Withdrawn
NiaprazineThe therapeutic efficacy of Niaprazine can be increased when used in combination with Magnesium sulfate.Experimental
NicardipineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Nicardipine.Approved, Investigational
NicergolineThe risk or severity of hypotension can be increased when Nicergoline is combined with Magnesium sulfate.Approved, Investigational
NicomorphineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Nicomorphine.Experimental
NicotineThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Nicotine.Approved
NifedipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nifedipine is combined with Magnesium sulfate.Approved
NiguldipineThe risk or severity of hypotension can be increased when Niguldipine is combined with Magnesium sulfate.Experimental
NilotinibThe metabolism of Magnesium sulfate can be decreased when combined with Nilotinib.Approved, Investigational
NiludipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Niludipine is combined with Magnesium sulfate.Experimental
NilvadipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nilvadipine is combined with Magnesium sulfate.Approved, Investigational
NimesulideThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimesulide is combined with Magnesium sulfate.Approved, Investigational, Withdrawn
NimodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium sulfate.Approved, Investigational
NisoldipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nisoldipine is combined with Magnesium sulfate.Approved
NisoxetineThe therapeutic efficacy of Nisoxetine can be increased when used in combination with Magnesium sulfate.Experimental
NitrazepamThe therapeutic efficacy of Nitrazepam can be increased when used in combination with Magnesium sulfate.Approved
NitrendipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Nitrendipine is combined with Magnesium sulfate.Approved, Investigational
NitroprussideMagnesium sulfate may increase the hypotensive activities of Nitroprusside.Approved, Investigational
Nitrous oxideThe therapeutic efficacy of Nitrous oxide can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
NomifensineThe therapeutic efficacy of Nomifensine can be increased when used in combination with Magnesium sulfate.Withdrawn
NordazepamThe therapeutic efficacy of Nordazepam can be increased when used in combination with Magnesium sulfate.Approved
NorfloxacinMagnesium sulfate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NormethadoneThe therapeutic efficacy of Normethadone can be increased when used in combination with Magnesium sulfate.Approved, Illicit
NortriptylineThe therapeutic efficacy of Nortriptyline can be increased when used in combination with Magnesium sulfate.Approved
NylidrinThe risk or severity of hypotension and neuromuscular blockade can be increased when Nylidrin is combined with Magnesium sulfate.Approved
OctamoxinThe therapeutic efficacy of Octamoxin can be increased when used in combination with Magnesium sulfate.Withdrawn
OfloxacinMagnesium sulfate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OlanzapineThe therapeutic efficacy of Olanzapine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
OlaparibThe metabolism of Magnesium sulfate can be decreased when combined with Olaparib.Approved
OlopatadineThe therapeutic efficacy of Olopatadine can be increased when used in combination with Magnesium sulfate.Approved
OmoconazoleThe therapeutic efficacy of Omoconazole can be increased when used in combination with Magnesium sulfate.Experimental
OndansetronThe therapeutic efficacy of Ondansetron can be increased when used in combination with Magnesium sulfate.Approved
OpipramolThe therapeutic efficacy of Opipramol can be increased when used in combination with Magnesium sulfate.Investigational
OpiumThe therapeutic efficacy of Opium can be increased when used in combination with Magnesium sulfate.Approved, Illicit
OrbifloxacinMagnesium sulfate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Vet Approved
OrlistatOrlistat can cause a decrease in the absorption of Magnesium sulfate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
OrphenadrineThe therapeutic efficacy of Orphenadrine can be increased when used in combination with Magnesium sulfate.Approved
OrvepitantThe therapeutic efficacy of Orvepitant can be increased when used in combination with Magnesium sulfate.Investigational
OsanetantThe therapeutic efficacy of Osanetant can be increased when used in combination with Magnesium sulfate.Investigational
OsimertinibThe serum concentration of Magnesium sulfate can be increased when it is combined with Osimertinib.Approved
OtiloniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Otilonium.Experimental, Investigational
OxaflozaneThe therapeutic efficacy of Oxaflozane can be increased when used in combination with Magnesium sulfate.Experimental
OxaprotilineThe therapeutic efficacy of Oxaprotiline can be increased when used in combination with Magnesium sulfate.Experimental
OxazepamThe therapeutic efficacy of Oxazepam can be increased when used in combination with Magnesium sulfate.Approved
OxcarbazepineThe therapeutic efficacy of Oxcarbazepine can be increased when used in combination with Magnesium sulfate.Approved
OXI-4503The serum concentration of OXI-4503 can be decreased when it is combined with Magnesium sulfate.Investigational
OxiconazoleThe therapeutic efficacy of Oxiconazole can be increased when used in combination with Magnesium sulfate.Approved
OxiracetamThe therapeutic efficacy of Oxiracetam can be increased when used in combination with Magnesium sulfate.Experimental
OxitriptanThe therapeutic efficacy of Oxitriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Nutraceutical
OxitropiumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Oxitropium.Investigational
Oxolinic acidMagnesium sulfate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
OxprenololThe therapeutic efficacy of Oxprenolol can be increased when used in combination with Magnesium sulfate.Approved
OxtriphyllineMagnesium sulfate may increase the excretion rate of Oxtriphylline which could result in a lower serum level and potentially a reduction in efficacy.Approved
OxybutyninThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Oxybutynin.Approved, Investigational
OxycodoneThe therapeutic efficacy of Oxycodone can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
OxymorphoneThe therapeutic efficacy of Oxymorphone can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
OxypertineThe therapeutic efficacy of Oxypertine can be increased when used in combination with Magnesium sulfate.Experimental
OxyphencyclimineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Oxyphencyclimine.Approved
OxyphenisatinThe therapeutic efficacy of Oxyphenisatin can be decreased when used in combination with Magnesium sulfate.Investigational, Withdrawn
OxyphenoniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Oxyphenonium.Approved
OxytetracyclineThe therapeutic efficacy of Oxytetracycline can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Magnesium sulfate can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe therapeutic efficacy of Paliperidone can be increased when used in combination with Magnesium sulfate.Approved
PalonosetronThe therapeutic efficacy of Palonosetron can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Magnesium sulfate.Approved
PancuroniumThe therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium sulfate.Approved
ParaldehydeThe therapeutic efficacy of Paraldehyde can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ParamethadioneThe therapeutic efficacy of Paramethadione can be increased when used in combination with Magnesium sulfate.Approved
PargylineThe therapeutic efficacy of Pargyline can be increased when used in combination with Magnesium sulfate.Approved
ParomomycinThe therapeutic efficacy of Paromomycin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ParoxetineThe therapeutic efficacy of Paroxetine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Patent BlueThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Patent Blue.Approved
PazufloxacinMagnesium sulfate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
PefloxacinMagnesium sulfate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PeldesineMagnesium sulfate may increase the excretion rate of Peldesine which could result in a lower serum level and potentially a reduction in efficacy.Experimental, Investigational
PemetrexedMagnesium sulfate may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
PenbutololThe therapeutic efficacy of Penbutolol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PenciclovirMagnesium sulfate may increase the excretion rate of Penciclovir which could result in a lower serum level and potentially a reduction in efficacy.Approved
PenfluridolThe therapeutic efficacy of Penfluridol can be increased when used in combination with Magnesium sulfate.Experimental
PenimepicyclineThe therapeutic efficacy of Penimepicycline can be increased when used in combination with Magnesium sulfate.Experimental
PentaerithritylThe therapeutic efficacy of Pentaerithrityl can be decreased when used in combination with Magnesium sulfate.Experimental
PentazocineThe therapeutic efficacy of Pentazocine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PenthienateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Penthienate.Experimental
PentifyllineMagnesium sulfate may increase the excretion rate of Pentifylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
PentobarbitalThe therapeutic efficacy of Pentobarbital can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Pentolinium.Approved
PentoxifyllineMagnesium sulfate may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
PerampanelThe therapeutic efficacy of Perampanel can be increased when used in combination with Magnesium sulfate.Approved
PerazineThe therapeutic efficacy of Perazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PergolideThe therapeutic efficacy of Pergolide can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved, Withdrawn
PerospironeThe therapeutic efficacy of Perospirone can be increased when used in combination with Magnesium sulfate.Approved
PerphenazineThe therapeutic efficacy of Perphenazine can be increased when used in combination with Magnesium sulfate.Approved
PethidineThe therapeutic efficacy of Pethidine can be increased when used in combination with Magnesium sulfate.Approved
PhenacemideThe therapeutic efficacy of Phenacemide can be increased when used in combination with Magnesium sulfate.Approved
PhenazocineThe therapeutic efficacy of Phenazocine can be increased when used in combination with Magnesium sulfate.Experimental
PhencyclidineThe therapeutic efficacy of Phencyclidine can be increased when used in combination with Magnesium sulfate.Illicit
PhenelzineThe therapeutic efficacy of Phenelzine can be increased when used in combination with Magnesium sulfate.Approved
PhenethylamineThe therapeutic efficacy of Phenethylamine can be increased when used in combination with Magnesium sulfate.Experimental
PheneturideThe therapeutic efficacy of Pheneturide can be increased when used in combination with Magnesium sulfate.Experimental
PhenglutarimideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Phenglutarimide.Experimental
PhenibutThe therapeutic efficacy of Phenibut can be increased when used in combination with Magnesium sulfate.Experimental
PheniprazineThe therapeutic efficacy of Pheniprazine can be increased when used in combination with Magnesium sulfate.Withdrawn
PhenobarbitalThe therapeutic efficacy of Phenobarbital can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PhenolphthaleinThe therapeutic efficacy of Phenolphthalein can be decreased when used in combination with Magnesium sulfate.Approved, Withdrawn
PhenoperidineThe therapeutic efficacy of Phenoperidine can be increased when used in combination with Magnesium sulfate.Experimental
PhenoxybenzamineThe risk or severity of hypotension can be increased when Phenoxybenzamine is combined with Magnesium sulfate.Approved
PhenoxypropazineThe therapeutic efficacy of Phenoxypropazine can be increased when used in combination with Magnesium sulfate.Withdrawn
PhenprobamateThe therapeutic efficacy of Phenprobamate can be increased when used in combination with Magnesium sulfate.Experimental
PhensuximideThe therapeutic efficacy of Phensuximide can be increased when used in combination with Magnesium sulfate.Approved
PhentermineThe therapeutic efficacy of Phentermine can be increased when used in combination with Magnesium sulfate.Approved, Illicit
PhentolamineThe risk or severity of hypotension can be increased when Phentolamine is combined with Magnesium sulfate.Approved
PhenytoinThe therapeutic efficacy of Phenytoin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PiclozotanThe therapeutic efficacy of Piclozotan can be increased when used in combination with Magnesium sulfate.Investigational
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Magnesium sulfate.Approved
PimavanserinThe therapeutic efficacy of Pimavanserin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PimozideThe therapeutic efficacy of Pimozide can be increased when used in combination with Magnesium sulfate.Approved
PinaveriumThe risk or severity of hypotension and neuromuscular blockade can be increased when Pinaverium is combined with Magnesium sulfate.Approved
PinazepamThe therapeutic efficacy of Pinazepam can be increased when used in combination with Magnesium sulfate.Experimental
PindololThe therapeutic efficacy of Pindolol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PipamperoneThe therapeutic efficacy of Pipamperone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PipecuroniumThe therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium sulfate.Approved
Pipemidic acidMagnesium sulfate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
PipenzolateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Pipenzolate.Experimental
PiperidolateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Piperidolate.Experimental
PipotiazineThe therapeutic efficacy of Pipotiazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PirenzepineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Pirenzepine.Approved
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Magnesium sulfate.Approved
PiritramideThe therapeutic efficacy of Piritramide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PirlimycinThe therapeutic efficacy of Pirlimycin can be increased when used in combination with Magnesium sulfate.Vet Approved
PirlindoleThe therapeutic efficacy of Pirlindole can be increased when used in combination with Magnesium sulfate.Approved
Piromidic acidMagnesium sulfate can cause a decrease in the absorption of Piromidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
PitolisantThe serum concentration of Magnesium sulfate can be decreased when it is combined with Pitolisant.Approved, Investigational
PivagabineThe therapeutic efficacy of Pivagabine can be increased when used in combination with Magnesium sulfate.Investigational
PivhydrazineThe therapeutic efficacy of Pivhydrazine can be increased when used in combination with Magnesium sulfate.Withdrawn
PizotifenThe therapeutic efficacy of Pizotifen can be increased when used in combination with Magnesium sulfate.Approved
Plantago seedThe therapeutic efficacy of Plantago seed can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
PlazomicinThe therapeutic efficacy of Plazomicin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PlecanatideThe therapeutic efficacy of Plecanatide can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
PoldineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Poldine.Experimental
PolycarbophilThe therapeutic efficacy of Polycarbophil can be decreased when used in combination with Magnesium sulfate.Approved
Polyethylene glycolThe therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Magnesium sulfate.Approved, Vet Approved
Polymyxin B SulfateThe therapeutic efficacy of Polymyxin B Sulfate can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PolythiazideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Magnesium sulfate.Approved
PomalidomideThe therapeutic efficacy of Pomalidomide can be increased when used in combination with Magnesium sulfate.Approved
PosaconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PotassiumThe risk or severity of adverse effects can be increased when Potassium is combined with Magnesium sulfate.Approved, Experimental
Potassium acetateThe therapeutic efficacy of Potassium acetate can be decreased when used in combination with Magnesium sulfate.Approved, Investigational
Potassium cationThe risk or severity of adverse effects can be increased when Potassium cation is combined with Magnesium sulfate.Approved, Investigational
Potassium CitrateThe risk or severity of adverse effects can be increased when Potassium Citrate is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
PramipexoleMagnesium sulfate may increase the sedative activities of Pramipexole.Approved, Investigational
PrazepamThe therapeutic efficacy of Prazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
PrazosinThe risk or severity of hypotension can be increased when Prazosin is combined with Magnesium sulfate.Approved
PregabalinThe therapeutic efficacy of Pregabalin can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
PrenylamineThe risk or severity of hypotension and neuromuscular blockade can be increased when Prenylamine is combined with Magnesium sulfate.Withdrawn
PridinolThe therapeutic efficacy of Pridinol can be increased when used in combination with Magnesium sulfate.Experimental
PrifiniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Prifinium.Experimental
PrimidoneThe therapeutic efficacy of Primidone can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ProcainamideThe therapeutic efficacy of Procainamide can be increased when used in combination with Magnesium sulfate.Approved
ProcaineThe therapeutic efficacy of Procaine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ProcarbazineThe therapeutic efficacy of Procarbazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ProchlorperazineThe therapeutic efficacy of Prochlorperazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ProcyclidineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Procyclidine.Approved
ProgabideThe therapeutic efficacy of Progabide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PromazineThe therapeutic efficacy of Promazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PromethazineThe therapeutic efficacy of Promethazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PropanididThe therapeutic efficacy of Propanidid can be increased when used in combination with Magnesium sulfate.Experimental
PropanthelineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Propantheline.Approved
PropentofyllineMagnesium sulfate may increase the excretion rate of Propentofylline which could result in a lower serum level and potentially a reduction in efficacy.Investigational
PropericiazineThe therapeutic efficacy of Propericiazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
PropiomazineThe therapeutic efficacy of Propiomazine can be increased when used in combination with Magnesium sulfate.Approved
PropiopromazineThe therapeutic efficacy of Propiopromazine can be increased when used in combination with Magnesium sulfate.Vet Approved
PropiverineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Propiverine.Approved, Investigational
PropofolThe therapeutic efficacy of Propofol can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ProthipendylThe therapeutic efficacy of Prothipendyl can be increased when used in combination with Magnesium sulfate.Investigational
ProtriptylineThe therapeutic efficacy of Protriptyline can be increased when used in combination with Magnesium sulfate.Approved
ProxibarbalThe therapeutic efficacy of Proxibarbal can be increased when used in combination with Magnesium sulfate.Experimental
ProxyphyllineMagnesium sulfate may increase the excretion rate of Proxyphylline which could result in a lower serum level and potentially a reduction in efficacy.Experimental
PrucaloprideThe therapeutic efficacy of Prucalopride can be decreased when used in combination with Magnesium sulfate.Approved
PrulifloxacinMagnesium sulfate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
PRX-08066The therapeutic efficacy of PRX-08066 can be increased when used in combination with Magnesium sulfate.Investigational
PsilocybineThe therapeutic efficacy of Psilocybine can be increased when used in combination with Magnesium sulfate.Investigational
PuromycinThe therapeutic efficacy of Puromycin can be increased when used in combination with Magnesium sulfate.Experimental
PyrantelThe therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
PyrithyldioneThe therapeutic efficacy of Pyrithyldione can be increased when used in combination with Magnesium sulfate.Experimental
Pyrophosphoric acidThe serum concentration of Pyrophosphoric acid can be decreased when it is combined with Magnesium sulfate.Approved, Experimental
QuazepamThe therapeutic efficacy of Quazepam can be increased when used in combination with Magnesium sulfate.Approved, Illicit
QuetiapineThe therapeutic efficacy of Quetiapine can be increased when used in combination with Magnesium sulfate.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Quinethazone is combined with Magnesium sulfate.Approved
QuinidineThe therapeutic efficacy of Quinidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
QuinineThe therapeutic efficacy of Quinine can be increased when used in combination with Magnesium sulfate.Approved
QuinupramineThe therapeutic efficacy of Quinupramine can be increased when used in combination with Magnesium sulfate.Experimental
RacloprideThe therapeutic efficacy of Raclopride can be increased when used in combination with Magnesium sulfate.Investigational
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Magnesium sulfate.Approved
RamelteonThe therapeutic efficacy of Ramelteon can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RamosetronThe therapeutic efficacy of Ramosetron can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RapacuroniumThe therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium sulfate.Withdrawn
RasagilineThe therapeutic efficacy of Rasagiline can be increased when used in combination with Magnesium sulfate.Approved
RavuconazoleThe therapeutic efficacy of Ravuconazole can be increased when used in combination with Magnesium sulfate.Investigational
ReboxetineThe therapeutic efficacy of Reboxetine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RemacemideThe therapeutic efficacy of Remacemide can be increased when used in combination with Magnesium sulfate.Investigational
RemifentanilThe therapeutic efficacy of Remifentanil can be increased when used in combination with Magnesium sulfate.Approved
RemoxiprideThe therapeutic efficacy of Remoxipride can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
RenzaprideThe therapeutic efficacy of Renzapride can be increased when used in combination with Magnesium sulfate.Investigational
RepinotanThe therapeutic efficacy of Repinotan can be increased when used in combination with Magnesium sulfate.Investigational
ReposalThe therapeutic efficacy of Reposal can be increased when used in combination with Magnesium sulfate.Approved
ReserpineThe therapeutic efficacy of Reserpine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RevefenacinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Revefenacin.Investigational
RibostamycinThe therapeutic efficacy of Ribostamycin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RifampicinThe metabolism of Magnesium sulfate can be increased when combined with Rifampicin.Approved
RifamycinThe metabolism of Magnesium sulfate can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Magnesium sulfate can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe metabolism of Magnesium sulfate can be increased when combined with Rifaximin.Approved, Investigational
RiluzoleThe therapeutic efficacy of Riluzole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RimexoloneThe metabolism of Magnesium sulfate can be increased when combined with Rimexolone.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Magnesium sulfate.Approved, Investigational
RisperidoneThe therapeutic efficacy of Risperidone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RitanserinThe therapeutic efficacy of Ritanserin can be increased when used in combination with Magnesium sulfate.Investigational
RitonavirThe metabolism of Magnesium sulfate can be decreased when combined with Ritonavir.Approved, Investigational
RizatriptanThe therapeutic efficacy of Rizatriptan can be increased when used in combination with Magnesium sulfate.Approved
RociverineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Rociverine.Experimental
RocuroniumThe therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium sulfate.Approved
RolipramThe therapeutic efficacy of Rolipram can be increased when used in combination with Magnesium sulfate.Investigational
RolitetracyclineThe therapeutic efficacy of Rolitetracycline can be increased when used in combination with Magnesium sulfate.Approved
RolofyllineThe risk or severity of adverse effects can be increased when Rolofylline is combined with Magnesium sulfate.Investigational
RomifidineThe therapeutic efficacy of Romifidine can be increased when used in combination with Magnesium sulfate.Vet Approved
RopiniroleThe therapeutic efficacy of Ropinirole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
RosoxacinMagnesium sulfate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
RotigotineThe therapeutic efficacy of Rotigotine can be increased when used in combination with Magnesium sulfate.Approved
RP-5063The therapeutic efficacy of RP-5063 can be increased when used in combination with Magnesium sulfate.Investigational
RufinamideThe therapeutic efficacy of Rufinamide can be increased when used in combination with Magnesium sulfate.Approved
RufloxacinMagnesium sulfate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
SafinamideThe therapeutic efficacy of Safinamide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SafrazineThe therapeutic efficacy of Safrazine can be increased when used in combination with Magnesium sulfate.Withdrawn
SaquinavirThe metabolism of Magnesium sulfate can be decreased when combined with Saquinavir.Approved, Investigational
SarafloxacinMagnesium sulfate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Vet Approved, Withdrawn
SaredutantThe therapeutic efficacy of Saredutant can be increased when used in combination with Magnesium sulfate.Investigational
SarilumabThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Sarilumab.Approved, Investigational
SarpogrelateThe therapeutic efficacy of Sarpogrelate can be increased when used in combination with Magnesium sulfate.Investigational
ScopolamineThe therapeutic efficacy of Scopolamine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SecobarbitalThe therapeutic efficacy of Secobarbital can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
SelegilineThe therapeutic efficacy of Selegiline can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
SeletracetamThe risk or severity of hypotension and neuromuscular blockade can be increased when Seletracetam is combined with Magnesium sulfate.Investigational
SennosidesThe therapeutic efficacy of Sennosides can be decreased when used in combination with Magnesium sulfate.Approved
SerotoninThe therapeutic efficacy of Serotonin can be increased when used in combination with Magnesium sulfate.Investigational, Nutraceutical
SertaconazoleThe therapeutic efficacy of Sertaconazole can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SertindoleThe therapeutic efficacy of Sertindole can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
SertralineThe therapeutic efficacy of Sertraline can be increased when used in combination with Magnesium sulfate.Approved
SevofluraneThe therapeutic efficacy of Sevoflurane can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
SibutramineThe therapeutic efficacy of Sibutramine can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational, Withdrawn
SilodosinThe risk or severity of hypotension can be increased when Silodosin is combined with Magnesium sulfate.Approved
SiltuximabThe serum concentration of Magnesium sulfate can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Magnesium sulfate can be increased when it is combined with Simeprevir.Approved
SisomicinThe therapeutic efficacy of Sisomicin can be increased when used in combination with Magnesium sulfate.Investigational
SitafloxacinMagnesium sulfate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental, Investigational
Sodium glycerophosphateThe serum concentration of Sodium glycerophosphate can be decreased when it is combined with Magnesium sulfate.Approved
Sodium oxybateThe therapeutic efficacy of Sodium oxybate can be increased when used in combination with Magnesium sulfate.Approved
Sodium phosphate, monobasicThe serum concentration of Sodium phosphate, monobasic can be decreased when it is combined with Magnesium sulfate.Approved
Sodium sulfateThe therapeutic efficacy of Sodium sulfate can be decreased when used in combination with Magnesium sulfate.Approved, Vet Approved
Sodium tartrateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Magnesium sulfate.Approved
Sodium tripolyphosphateThe serum concentration of Sodium tripolyphosphate can be decreased when it is combined with Magnesium sulfate.Vet Approved
SolifenacinThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Solifenacin.Approved
SorbitolThe therapeutic efficacy of Sorbitol can be decreased when used in combination with Magnesium sulfate.Approved
SparfloxacinMagnesium sulfate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
SpiradolineThe risk or severity of adverse effects can be increased when Spiradoline is combined with Magnesium sulfate.Investigational
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Magnesium sulfate.Approved
St. John's WortThe therapeutic efficacy of St. John's Wort can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Magnesium sulfate can be increased when it is combined with Stiripentol.Approved
StreptomycinThe therapeutic efficacy of Streptomycin can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
StyramateThe therapeutic efficacy of Styramate can be increased when used in combination with Magnesium sulfate.Experimental
SuccinylcholineThe therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium sulfate.Approved
SufentanilThe therapeutic efficacy of Sufentanil can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SulconazoleThe therapeutic efficacy of Sulconazole can be increased when used in combination with Magnesium sulfate.Approved
SulpirideThe therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SulthiameThe therapeutic efficacy of Sulthiame can be increased when used in combination with Magnesium sulfate.Experimental
SultoprideThe therapeutic efficacy of Sultopride can be increased when used in combination with Magnesium sulfate.Experimental
SumatriptanThe therapeutic efficacy of Sumatriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
SuvorexantMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TalbutalThe therapeutic efficacy of Talbutal can be increased when used in combination with Magnesium sulfate.Approved, Illicit
TalopramThe therapeutic efficacy of Talopram can be increased when used in combination with Magnesium sulfate.Experimental
TamsulosinThe risk or severity of hypotension can be increased when Tamsulosin is combined with Magnesium sulfate.Approved, Investigational
TandospironeThe therapeutic efficacy of Tandospirone can be increased when used in combination with Magnesium sulfate.Investigational
TapentadolThe therapeutic efficacy of Tapentadol can be increased when used in combination with Magnesium sulfate.Approved
Tartaric acidThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tartaric acid.Approved
TasimelteonThe therapeutic efficacy of Tasimelteon can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TD-8954The therapeutic efficacy of TD-8954 can be increased when used in combination with Magnesium sulfate.Investigational
Technetium Tc-99m ciprofloxacinMagnesium sulfate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
Technetium Tc-99m polyphosphateThe serum concentration of Technetium Tc-99m polyphosphate can be decreased when it is combined with Magnesium sulfate.Approved
Technetium Tc-99m pyrophosphateThe serum concentration of Technetium Tc-99m pyrophosphate can be decreased when it is combined with Magnesium sulfate.Approved
Tedizolid phosphateThe therapeutic efficacy of Tedizolid phosphate can be increased when used in combination with Magnesium sulfate.Approved
TegaserodThe therapeutic efficacy of Tegaserod can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
TelaprevirThe metabolism of Magnesium sulfate can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Magnesium sulfate can be decreased when combined with Telithromycin.Approved
TemafloxacinMagnesium sulfate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
TemazepamThe therapeutic efficacy of Temazepam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TerazosinThe risk or severity of hypotension can be increased when Terazosin is combined with Magnesium sulfate.Approved
TerconazoleThe therapeutic efficacy of Terconazole can be increased when used in combination with Magnesium sulfate.Approved
TerodilineThe risk or severity of hypotension and neuromuscular blockade can be increased when Terodiline is combined with Magnesium sulfate.Experimental
TetracyclineThe therapeutic efficacy of Tetracycline can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
TetraethylammoniumThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Tetraethylammonium.Experimental, Investigational
TetrahydrocannabivarinThe therapeutic efficacy of Tetrahydrocannabivarin can be increased when used in combination with Magnesium sulfate.Investigational
TetrahydropalmatineThe therapeutic efficacy of Tetrahydropalmatine can be increased when used in combination with Magnesium sulfate.Investigational
TetrandrineThe risk or severity of hypotension and neuromuscular blockade can be increased when Tetrandrine is combined with Magnesium sulfate.Experimental
TetrazepamThe therapeutic efficacy of Tetrazepam can be increased when used in combination with Magnesium sulfate.Experimental
TetrodotoxinThe therapeutic efficacy of Tetrodotoxin can be increased when used in combination with Magnesium sulfate.Investigational
ThalidomideMagnesium sulfate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineMagnesium sulfate may increase the excretion rate of Theobromine which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
TheodrenalineMagnesium sulfate may increase the excretion rate of Theodrenaline which could result in a lower serum level and potentially a reduction in efficacy.Investigational
ThiamylalThe therapeutic efficacy of Thiamylal can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ThiazinamThe therapeutic efficacy of Thiazinam can be increased when used in combination with Magnesium sulfate.Experimental
ThiethylperazineThe therapeutic efficacy of Thiethylperazine can be increased when used in combination with Magnesium sulfate.Withdrawn
ThiocolchicosideThe therapeutic efficacy of Thiocolchicoside can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ThiopentalThe therapeutic efficacy of Thiopental can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
ThiopropazateThe therapeutic efficacy of Thiopropazate can be increased when used in combination with Magnesium sulfate.Experimental
ThioproperazineThe therapeutic efficacy of Thioproperazine can be increased when used in combination with Magnesium sulfate.Approved
ThiopyrophosphateThe serum concentration of Thiopyrophosphate can be decreased when it is combined with Magnesium sulfate.Experimental
ThioridazineThe therapeutic efficacy of Thioridazine can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
ThiothixeneThe therapeutic efficacy of Thiothixene can be increased when used in combination with Magnesium sulfate.Approved
ThonzylamineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Thonzylamine.Approved
TiagabineThe therapeutic efficacy of Tiagabine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TianeptineThe therapeutic efficacy of Tianeptine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TiaprideThe therapeutic efficacy of Tiapride can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Ticrynafen is combined with Magnesium sulfate.Withdrawn
Tiemonium iodideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tiemonium iodide.Experimental
TigecyclineThe therapeutic efficacy of Tigecycline can be increased when used in combination with Magnesium sulfate.Approved
TiletamineThe therapeutic efficacy of Tiletamine can be increased when used in combination with Magnesium sulfate.Vet Approved
TilidineThe therapeutic efficacy of Tilidine can be increased when used in combination with Magnesium sulfate.Experimental
Tiludronic acidThe serum concentration of Tiludronic acid can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
TimepidiumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Timepidium.Experimental
TioconazoleThe therapeutic efficacy of Tioconazole can be increased when used in combination with Magnesium sulfate.Approved
TiotropiumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tiotropium.Approved
TipranavirThe metabolism of Magnesium sulfate can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe therapeutic efficacy of Tizanidine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TobramycinThe therapeutic efficacy of Tobramycin can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TocilizumabThe serum concentration of Magnesium sulfate can be decreased when it is combined with Tocilizumab.Approved
TofisopamThe therapeutic efficacy of Tofisopam can be increased when used in combination with Magnesium sulfate.Approved
TolazolineThe risk or severity of hypotension can be increased when Tolazoline is combined with Magnesium sulfate.Approved, Vet Approved
TolcaponeThe therapeutic efficacy of Tolcapone can be increased when used in combination with Magnesium sulfate.Approved, Withdrawn
TolevamerThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Tolevamer.Approved, Investigational
Tolfenamic AcidThe risk or severity of hypotension and neuromuscular blockade can be increased when Tolfenamic Acid is combined with Magnesium sulfate.Approved, Investigational
ToloxatoneThe therapeutic efficacy of Toloxatone can be increased when used in combination with Magnesium sulfate.Approved
TolperisoneThe therapeutic efficacy of Tolperisone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TolterodineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tolterodine.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Tolvaptan is combined with Magnesium sulfate.Approved
TopiramateThe therapeutic efficacy of Topiramate can be increased when used in combination with Magnesium sulfate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Magnesium sulfate.Approved
TramadolThe therapeutic efficacy of Tramadol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TramiprosateThe therapeutic efficacy of Tramiprosate can be increased when used in combination with Magnesium sulfate.Investigational
TranilastThe risk or severity of hypotension and neuromuscular blockade can be increased when Tranilast is combined with Magnesium sulfate.Approved, Investigational
TranylcypromineThe therapeutic efficacy of Tranylcypromine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrazodoneThe therapeutic efficacy of Trazodone can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Magnesium sulfate.Approved
TriazolamThe therapeutic efficacy of Triazolam can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Tricaine methanesulfonateThe therapeutic efficacy of Tricaine methanesulfonate can be increased when used in combination with Magnesium sulfate.Vet Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Trichlormethiazide is combined with Magnesium sulfate.Approved, Vet Approved
TrichloroethyleneThe therapeutic efficacy of Trichloroethylene can be increased when used in combination with Magnesium sulfate.Approved
TriclofosThe therapeutic efficacy of Triclofos can be increased when used in combination with Magnesium sulfate.Withdrawn
TridihexethylThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tridihexethyl.Withdrawn
TriethylenetetramineThe serum concentration of Magnesium sulfate can be decreased when it is combined with Triethylenetetramine.Approved, Investigational
TrifluoperazineThe therapeutic efficacy of Trifluoperazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrifluperidolThe therapeutic efficacy of Trifluperidol can be increased when used in combination with Magnesium sulfate.Experimental
TriflupromazineThe therapeutic efficacy of Triflupromazine can be increased when used in combination with Magnesium sulfate.Approved, Vet Approved
TrihexyphenidylThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Trihexyphenidyl.Approved
TrimazosinThe risk or severity of hypotension can be increased when Trimazosin is combined with Magnesium sulfate.Experimental
TrimebutineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Trimebutine.Approved
TrimethadioneThe therapeutic efficacy of Trimethadione can be increased when used in combination with Magnesium sulfate.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Magnesium sulfate is combined with Trimethaphan.Approved, Investigational
TrimipramineThe therapeutic efficacy of Trimipramine can be increased when used in combination with Magnesium sulfate.Approved
TriprolidineThe therapeutic efficacy of Triprolidine can be increased when used in combination with Magnesium sulfate.Approved
TroleandomycinThe metabolism of Magnesium sulfate can be decreased when combined with Troleandomycin.Approved
TropatepineThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tropatepine.Experimental
TropicamideThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Tropicamide.Approved, Investigational
TropisetronThe therapeutic efficacy of Tropisetron can be increased when used in combination with Magnesium sulfate.Approved, Investigational
TrospiumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Trospium.Approved
TrovafloxacinMagnesium sulfate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
TubocurarineThe therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium sulfate.Approved
UlaritideThe risk or severity of adverse effects can be increased when Ularitide is combined with Magnesium sulfate.Investigational
UmeclidiniumThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Umeclidinium.Approved
UrapidilThe therapeutic efficacy of Urapidil can be increased when used in combination with Magnesium sulfate.Investigational
Uric AcidMagnesium sulfate may increase the excretion rate of Uric Acid which could result in a lower serum level and potentially a reduction in efficacy.Experimental, Investigational
VabicaserinThe therapeutic efficacy of Vabicaserin can be increased when used in combination with Magnesium sulfate.Investigational
ValaciclovirMagnesium sulfate may increase the excretion rate of Valaciclovir which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
ValerianThe therapeutic efficacy of Valerian can be increased when used in combination with Magnesium sulfate.Approved, Experimental, Investigational
ValganciclovirMagnesium sulfate may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.Approved, Investigational
ValnoctamideThe therapeutic efficacy of Valnoctamide can be increased when used in combination with Magnesium sulfate.Investigational
ValomaciclovirMagnesium sulfate may increase the excretion rate of Valomaciclovir which could result in a lower serum level and potentially a reduction in efficacy.Investigational
Valproic AcidThe therapeutic efficacy of Valproic Acid can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ValpromideThe therapeutic efficacy of Valpromide can be increased when used in combination with Magnesium sulfate.Experimental
VancomycinThe therapeutic efficacy of Vancomycin can be increased when used in combination with Magnesium sulfate.Approved
VecuroniumThe therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium sulfate.Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Magnesium sulfate.Approved
VenlafaxineThe therapeutic efficacy of Venlafaxine can be increased when used in combination with Magnesium sulfate.Approved
VeraliprideThe therapeutic efficacy of Veralipride can be increased when used in combination with Magnesium sulfate.Experimental
VerapamilThe risk or severity of hypotension can be increased when Verapamil is combined with Magnesium sulfate.Approved
VigabatrinThe therapeutic efficacy of Vigabatrin can be increased when used in combination with Magnesium sulfate.Approved
VilazodoneThe therapeutic efficacy of Vilazodone can be increased when used in combination with Magnesium sulfate.Approved
ViloxazineThe therapeutic efficacy of Viloxazine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
VinbarbitalThe therapeutic efficacy of Vinbarbital can be increased when used in combination with Magnesium sulfate.Experimental
VinpocetineThe therapeutic efficacy of Vinpocetine can be increased when used in combination with Magnesium sulfate.Investigational
Vinyl etherThe therapeutic efficacy of Vinyl ether can be increased when used in combination with Magnesium sulfate.Experimental
VinylbitalThe therapeutic efficacy of Vinylbital can be increased when used in combination with Magnesium sulfate.Experimental
VoriconazoleThe metabolism of Magnesium sulfate can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe therapeutic efficacy of Vortioxetine can be increased when used in combination with Magnesium sulfate.Approved, Investigational
WIN 55212-2The risk or severity of hypotension and neuromuscular blockade can be increased when WIN 55212-2 is combined with Magnesium sulfate.Experimental
WortmanninThe therapeutic efficacy of Wortmannin can be increased when used in combination with Magnesium sulfate.Experimental
XanthineMagnesium sulfate may increase the excretion rate of Xanthine which could result in a lower serum level and potentially a reduction in efficacy.Experimental
XipamideThe risk or severity of adverse effects can be increased when Xipamide is combined with Magnesium sulfate.Experimental
XP19986The therapeutic efficacy of XP19986 can be increased when used in combination with Magnesium sulfate.Investigational
XylazineThe therapeutic efficacy of Xylazine can be increased when used in combination with Magnesium sulfate.Vet Approved
YKP-1358The therapeutic efficacy of YKP-1358 can be increased when used in combination with Magnesium sulfate.Investigational
YohimbineThe therapeutic efficacy of Yohimbine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ZaleplonThe therapeutic efficacy of Zaleplon can be increased when used in combination with Magnesium sulfate.Approved, Illicit, Investigational
ZiconotideThe therapeutic efficacy of Ziconotide can be increased when used in combination with Magnesium sulfate.Approved
ZimelidineThe therapeutic efficacy of Zimelidine can be increased when used in combination with Magnesium sulfate.Withdrawn
ZiprasidoneThe therapeutic efficacy of Ziprasidone can be increased when used in combination with Magnesium sulfate.Approved
ZolazepamThe therapeutic efficacy of Zolazepam can be increased when used in combination with Magnesium sulfate.Vet Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Magnesium sulfate.Approved
ZolmitriptanThe therapeutic efficacy of Zolmitriptan can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ZolpidemThe therapeutic efficacy of Zolpidem can be increased when used in combination with Magnesium sulfate.Approved
ZonisamideThe therapeutic efficacy of Zonisamide can be increased when used in combination with Magnesium sulfate.Approved, Investigational
ZopicloneThe therapeutic efficacy of Zopiclone can be increased when used in combination with Magnesium sulfate.Approved
ZotepineThe therapeutic efficacy of Zotepine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Withdrawn
ZuclopenthixolThe therapeutic efficacy of Zuclopenthixol can be increased when used in combination with Magnesium sulfate.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Shinichi Yamamoto, Akifumi Sekitani, "BASIC MAGNESIUM SULFATE GRANULE, AND PROCESS FOR PRODUCTION THEREOF." U.S. Patent US20110042297, issued February 24, 2011.

US20110042297
General References
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  2. Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY: Prolonged maternal magnesium administration and bone metabolism in neonates. Early Hum Dev. 2010 Mar;86(3):187-91. doi: 10.1016/j.earlhumdev.2010.02.007. Epub 2010 Mar 12. [PubMed:20226604]
  3. Wedig KE, Kogan J, Schorry EK, Whitsett JA: Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4. [PubMed:16724078]
  4. Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM: Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. Acta Obstet Gynecol Scand. 2006;85(9):1099-103. [PubMed:16929415]
  5. Malaeb SN, Rassi AI, Haddad MC, Seoud MA, Yunis KA: Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol. 2004 May;34(5):384-6. Epub 2004 Feb 18. [PubMed:14985884]
  6. Matsuda Y, Maeda Y, Ito M, Sakamoto H, Masaoka N, Takada M, Sato K: Effect of magnesium sulfate treatment on neonatal bone abnormalities. Gynecol Obstet Invest. 1997;44(2):82-8. [PubMed:9286718]
  7. Schanler RJ, Smith LG Jr, Burns PA: Effects of long-term maternal intravenous magnesium sulfate therapy on neonatal calcium metabolism and bone mineral content. Gynecol Obstet Invest. 1997;43(4):236-41. [PubMed:9194621]
  8. Santi MD, Henry GW, Douglas GL: Magnesium sulfate treatment of preterm labor as a cause of abnormal neonatal bone mineralization. J Pediatr Orthop. 1994 Mar-Apr;14(2):249-53. [PubMed:8188843]
  9. Holcomb WL Jr, Shackelford GD, Petrie RH: Magnesium tocolysis and neonatal bone abnormalities: a controlled study. Obstet Gynecol. 1991 Oct;78(4):611-4. [PubMed:1923163]
  10. Cumming WA, Thomas VJ: Hypermagnesemia: a cause of abnormal metaphyses in the neonate. AJR Am J Roentgenol. 1989 May;152(5):1071-2. [PubMed:2705341]
  11. Lamm CI, Norton KI, Murphy RJ, Wilkins IA, Rabinowitz JG: Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr. 1988 Dec;113(6):1078-82. [PubMed:3193315]
  12. McGuinness GA, Weinstein MM, Cruikshank DP, Pitkin RM: Effects of magnesium sulfate treatment on perinatal calcium metabolism. II. Neonatal responses. Obstet Gynecol. 1980 Nov;56(5):595-600. [PubMed:7432730]
  13. Riaz M, Porat R, Brodsky NL, Hurt H: The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998 Nov-Dec;18(6 Pt 1):449-54. [PubMed:9848759]
External Links
Human Metabolome Database
HMDB0014791
KEGG Drug
D01108
PubChem Compound
24083
PubChem Substance
46508411
ChemSpider
22515
ChEBI
32599
ChEMBL
CHEMBL2021423
Therapeutic Targets Database
DAP000201
PharmGKB
PA450302
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Magnesium_sulfate
ATC Codes
A06AD04 — Magnesium sulfateV04CC02 — Magnesium sulfateA12CC02 — Magnesium sulfateD11AX05 — Magnesium sulfateB05XA05 — Magnesium sulfate
AHFS Codes
  • 56:12.00 — Cathartics and Laxatives
  • 28:12.92 — Miscellaneous Anticonvulsants
  • 40:12.00 — Replacement Preparations
MSDS
Download (72.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticPremature Births1
1CompletedPreventionPaclitaxel-induced Neuropathy1
1CompletedSupportive CareHead and Neck Carcinoma1
1RecruitingTreatmentCraniotomy / High Blood Pressure (Hypertension)1
1RecruitingTreatmentStroke, Ischemic1
1, 2CompletedPreventionPost Operative Pain1
1, 2CompletedTreatmentStroke, Acute1
1, 2CompletedTreatmentProphylaxis of preeclampsia1
1, 2RecruitingNot AvailableLack of Drug Action1
1, 2RecruitingTreatmentEpstein-Barr Virus (EBV) Infection and Neoplasia / X-linked Immunodeficiency With Magnesium Defect1
2Active Not RecruitingTreatmentMuscle Relaxation1
2CompletedPreventionAnalgesia1
2CompletedSupportive CareIdiopathic Scoliosis1
2CompletedTreatmentBronchiolitis / Magnesium, Abnormal Blood Level1
2CompletedTreatmentHand, Foot, and Mouth Disease1
2CompletedTreatmentNeuromuscular Block1
2RecruitingDiagnosticPain1
2RecruitingTreatmentPain, Neuropathic1
2RecruitingTreatmentSedation, Conscious1
2TerminatedTreatmentTraumatic Brain Injury (TBI)1
2, 3Active Not RecruitingTreatmentPostoperative pain1
2, 3CompletedPreventionCerebral Palsy (CP) / Premature Labour1
2, 3CompletedPreventionCesarean Section; Shivering1
2, 3CompletedTreatmentPerinatal Anoxic-ischemic Brain Injury1
2, 3CompletedTreatmentPost Partum Severe Preeclampsia / Severe Pre-eclampsia Postpartum1
2, 3CompletedTreatmentPostoperative pain1
2, 3CompletedTreatmentSevere Pre-eclampsia With Postnatal Complication1
2, 3CompletedTreatmentSickle Cell Disorders1
2, 3RecruitingPreventionPostoperative pain1
2, 3RecruitingTreatmentAcidosis, Respiratory / Alcohol Withdrawal Syndrome(AWS) / Magnesium Deficiency / Vitamin B1 deficiency / Wernicke's encephalopathy1
2, 3WithdrawnPreventionChronic Hypertension / Gestational Hypertension / Preeclampsia / Pregnancy associated hypertension / Superimposed Preeclampsia1
2, 3WithdrawnTreatmentAsthma Bronchial1
2, 3WithdrawnTreatmentHeadaches1
3CompletedPreventionCerebral Palsy (CP) / Intraventricular Hemorrhage / Periventricular Leukomalacia / Premature separation of placenta / Pulmonary Edemas1
3CompletedPreventionIncreased Intra Ocular Pressure (IOP)1
3CompletedPreventionNeoplasms, Brain / Seizures (Incl Subtypes)1
3CompletedPreventionSubarachnoid Hemorrhage1
3CompletedPreventionProphylaxis of preeclampsia1
3CompletedSupportive CareChemotherapeutic Agent Toxicity / Colorectal Cancers / Neuropathy / Neurotoxicity1
3CompletedSupportive CareColorectal Cancers / Neurotoxicity1
3CompletedTreatmentAcute Exacerbation of Chronic Obstructive Pulmonary Disease1
3CompletedTreatmentBrain Injury / Concussion, Brain / Craniocerebral Injuries1
3CompletedTreatmentCerebrovascular Accidents1
3CompletedTreatmentNonvalvular Atrial Fibrillation1
3CompletedTreatmentParents2
3CompletedTreatmentPerinatal Asphyxia , Moderate to Severe HIE1
3CompletedTreatmentSickle Cell Disorders1
3Not Yet RecruitingTreatmentThrombotic Thrombocytopenic Purpura (TTP)1
3RecruitingPreventionCerebral Palsy (CP)1
3RecruitingTreatmentBronchial Asthma1
3RecruitingTreatmentCesarean Section1
3RecruitingTreatmentHealthy Volunteers1
3TerminatedPreventionTransient Neurologic Syndrome1
3TerminatedSupportive CareNeuropathy / Pain / Recurrent Breast Carcinoma / Stage IV Breast Cancer1
3Unknown StatusPreventionBrain Injury / Cerebral Palsy (CP)1
3Unknown StatusPreventionModerate Hypoxic Ischemic Encephalopathy / Severe Hypoxic Ischemic Encephalopathy1
4CompletedNot AvailableNeuromuscular Block1
4CompletedPreventionCardiovascular Morbidity / Intubation Complications1
4CompletedPreventionHemorrhage1
4CompletedPreventionHyperalgesia1
4CompletedPreventionLiving Donor Liver Transplantation / Reperfusion Injury1
4CompletedPreventionNeoplasm, Gastric1
4CompletedPreventionPostoperative pain1
4CompletedSupportive CareLumbar Spine Disc Herniation1
4CompletedSupportive CarePreeclampsia1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Hypocalcemia / Infections, Cytomegalovirus1
4CompletedTreatmentAdjunct to general anesthesia therapy / Intravenous Anesthesia1
4CompletedTreatmentKnee Replacement Surgery1
4CompletedTreatmentNeuromuscular Blockade3
4CompletedTreatmentPostoperative pain1
4CompletedTreatmentPre-eclampsia Aggravated1
4CompletedTreatmentPreeclampsia1
4CompletedTreatmentSupratentorial Brain Tumor1
4Enrolling by InvitationDiagnosticColonoscopy1
4Not Yet RecruitingDiagnosticPreeclampsia1
4Not Yet RecruitingTreatmentNeuromuscular Blockade1
4Not Yet RecruitingTreatmentSevere Preeclampsia1
4RecruitingPreventionArrythmias1
4RecruitingPreventionPain in Pediatric Patients1
4RecruitingPreventionPreterm Labor Without Delivery1
4RecruitingPreventionPsychomotor Agitation1
4RecruitingSupportive CareChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingSupportive CareMalnutrition1
4RecruitingTreatmentAsthma Bronchial1
4RecruitingTreatmentDeep Neuromuscular Blockade / Magnesium Sulfate / Neuromuscular Blockade / Rocuronium1
4RecruitingTreatmentPostoperative pain1
4RecruitingTreatmentSevere Preeclampsia1
4TerminatedPreventionPreeclampsia1
4TerminatedPreventionPremature Labour1
4TerminatedSupportive CareArthritis Knee / Dexmedetomidine / Magnesium Sulfate1
4TerminatedTreatmentMagnesium Sulphate / Pain / Post Pulmonary Resection1
4Unknown StatusNot AvailableEmergence Agitation in Children / Emergence Delirium / Postopertive Delirium1
4Unknown StatusPreventionAcute Agitation / Pediatric Disorder1
4WithdrawnTreatmentPulmonary Disease, Chronic Obstructive1
Not AvailableActive Not RecruitingOtherPregnancy associated hypertension / Prophylaxis of preeclampsia1
Not AvailableCompletedNot AvailableAsthma Bronchial / Chronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedNot AvailableCancer, Breast1
Not AvailableCompletedNot AvailableEasy of Laryngoscopy Manipulation / Heart Rate / Mean Arterial Pressure / Patient Reaction to Intubation and Cuff Inflation / Vocal Cord Position or Movement1
Not AvailableCompletedNot AvailableHypertensive Disorder of Pregnancy1
Not AvailableCompletedNot AvailableIntubating Conditions1
Not AvailableCompletedNot AvailableMagnesium Sulfate Pharmacokinetics and Pharmacodynamics1
Not AvailableCompletedNot AvailablePreeclampsia / Pregnancy1
Not AvailableCompletedNot AvailableSevere Sepsis / Shock, Septic1
Not AvailableCompletedOtherBreast Surgery1
Not AvailableCompletedOtherPain / Postoperative pain1
Not AvailableCompletedPreventionBenign muscle neoplasm1
Not AvailableCompletedPreventionColorectal Cancers1
Not AvailableCompletedPreventionEmergence Delirium1
Not AvailableCompletedPreventionNonvalvular Atrial Fibrillation1
Not AvailableCompletedPreventionNonvalvular Atrial Fibrillation / Pain, Neuropathic1
Not AvailableCompletedPreventionOpioid Use, Unspecified, Uncomplicated / Pain1
Not AvailableCompletedPreventionPost Operative Sore Throat1
Not AvailableCompletedPreventionProphylaxis of preeclampsia1
Not AvailableCompletedTreatmentAlagille Syndrome / Biliary Atresia / Cholestasis1
Not AvailableCompletedTreatmentAsthma Bronchial1
Not AvailableCompletedTreatmentIntubation Conditions / Observation of Neuromuscular Block / Surgical Conditions1
Not AvailableCompletedTreatmentNonvalvular Atrial Fibrillation1
Not AvailableCompletedTreatmentObstetric Labour, Premature1
Not AvailableCompletedTreatmentPremature separation of placenta1
Not AvailableCompletedTreatmentRadius Fractures1
Not AvailableCompletedTreatmentRenal Colic1
Not AvailableCompletedTreatmentWheezy Bronchitis1
Not AvailableNot Yet RecruitingNot AvailablePreeclampsia1
Not AvailableNot Yet RecruitingPreventionProstatic Neoplasms1
Not AvailableNot Yet RecruitingTreatmentAsthma Acute / Asthma in Children1
Not AvailableNot Yet RecruitingTreatmentNeoplasms, Thyroid1
Not AvailableNot Yet RecruitingTreatmentThoracic Epidural Analgesia, Fracture Ribs1
Not AvailableRecruitingNot AvailableNeuromuscular Blockade1
Not AvailableRecruitingNot AvailablePostpartum Depression1
Not AvailableRecruitingPreventionAnaesthesia therapy1
Not AvailableRecruitingPreventionPain1
Not AvailableRecruitingTreatmentIschemia, Brain / Strokes1
Not AvailableRecruitingTreatmentNonvalvular Atrial Fibrillation1
Not AvailableRecruitingTreatmentPostpartum Hemorrhage1
Not AvailableRecruitingTreatmentPremature Labour1
Not AvailableTerminatedSupportive CarePostoperative pain1
Not AvailableTerminatedTreatmentPremature Births / Premature Labour1
Not AvailableTerminatedTreatmentPreterm Premature Rupture of Membranes1
Not AvailableTerminatedTreatmentPrimary Hypomagnesemia (Disorder)1
Not AvailableUnknown StatusNot AvailableCerebral Aneurysms1
Not AvailableUnknown StatusNot AvailableHallux Valgus1
Not AvailableUnknown StatusPreventionPain2
Not AvailableUnknown StatusPreventionPostoperative pain1
Not AvailableUnknown StatusTreatmentAcute Severe Asthma1
Not AvailableUnknown StatusTreatmentAsthma Bronchial1
Not AvailableUnknown StatusTreatmentMuscle Relaxation1

Pharmacoeconomics

Manufacturers
  • Abraxis pharmaceutical products
  • Hospira inc
Packagers
  • Denison Pharmaceuticals Inc.
  • Gallipot
  • Hospira Inc.
  • Pharmakon
  • Pharmedium
  • QOL Medical
  • Spectrum Pharmaceuticals
  • Vi-Jon Laboratories Inc.
  • Walgreen Co.
Dosage forms
FormRouteStrength
SolutionIntramuscular; Intravenous500 mg
TabletOral
Powder, for solutionOral
Capsule, liquid filledOral
CapsuleOral
LiquidOral
InjectionIntrathecal
OintmentTopical400 mg/g
CrystalOral; Topical1 g/g
GranuleOral1 g/g
GranuleOral100 kg/100kg
GranuleOral; Topical1 g/g
GranuleOral; Topical1.81 kg/100kg
Granule, for solutionOral; Topical1 g/g
Granule, for solutionOral; Topical100 g/100g
Powder, for solutionOral100 %
GranuleTopical2.72 kg/2.72kg
GranuleOral; Topical100 g/100g
PowderOral
PowderOral100 %
GranuleOral100 g/100g
Granule, for solutionOral1 g/g
Powder, for solutionOral1000 mg/g
Injection, emulsionIntravenous
InjectionIntravenous1 g/100mL
InjectionIntravenous2 g/50mL
InjectionIntravenous20 g/500mL
InjectionIntravenous4 g/100mL
InjectionIntravenous4 g/50mL
InjectionIntravenous40 g/1000mL
Injection, solutionIntramuscular; Intravenous.5 g/mL
Injection, solutionIntramuscular; Intravenous500 mg/mL
Injection, solutionIntravenous20 g/500mL
Injection, solutionIntravenous20 g/250mL
Injection, solutionIntravenous4 g/50mL
Injection, solutionIntravenous4 g/100mL
Injection, solutionIntravenous40 mg/mL
Injection, solutionIntravenous80 mg/mL
LiquidTopical45 %
Injection, solutionIntravenous1 g/100mL
Injection, solutionIntravenous10 mg/mL
Injection, solutionIntravenous20 mg/mL
LiquidIntramuscular; Intravenous200 mg
LiquidIntramuscular500 mg
LiquidIntramuscular; Intravenous500 mg
Granule, for solutionOral; Topical1 kg/kg
LiquidIntravenous
PowderTopical10 g/10g
CrystalOral; Topical100 g/100g
For solutionTopical1 kg/kg
GranuleOral3.63 kg/3.63kg
Granule, for solutionOral1 kg/kg
EmulsionIntravenous
KitOral
Solution, concentrateOral
LiquidIrrigation
SolutionIntravenous
Prices
Unit descriptionCostUnit
Elliotts b solution ampule4.71USD ml
Magnesium Sulfate 50% Solution 2ml Vial0.92USD vial
Magnesium sulfate powder0.29USD g
Magnesium-ns 6 g/50 ml bag0.29USD ml
Magnesium-ns 4 g/50 ml bag0.27USD ml
Magnesium-ns 3 g/50 ml bag0.26USD ml
Magnesium sulfate-ns 2 gm bag0.25USD ml
Magnesium sulfate-ns 1 gm bag0.24USD ml
Magnesium-d5w 1 gm/100 ml soln0.07USD ml
Magnesium-lr 20 g/500 ml0.03USD ml
Magnesium-lr 40 g/500 ml bag0.03USD ml
Magnesium-lr 50 g/500 ml bag0.02USD ml
Epsom salt 100% powder0.01USD g
Magnesium sulf 4% iv soln0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6946149No2003-03-072023-03-07Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)1124 °C (decomposition)Not Available
water solubility710 mg/mLNot Available
logP-0.91Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7487
Blood Brain Barrier+0.9646
Caco-2 permeable-0.6267
P-glycoprotein substrateNon-substrate0.9137
P-glycoprotein inhibitor INon-inhibitor0.9194
P-glycoprotein inhibitor IINon-inhibitor0.9904
Renal organic cation transporterNon-inhibitor0.9521
CYP450 2C9 substrateNon-substrate0.8775
CYP450 2D6 substrateNon-substrate0.8213
CYP450 3A4 substrateNon-substrate0.7007
CYP450 1A2 substrateNon-inhibitor0.7767
CYP450 2C9 inhibitorNon-inhibitor0.7602
CYP450 2D6 inhibitorNon-inhibitor0.9115
CYP450 2C19 inhibitorNon-inhibitor0.7547
CYP450 3A4 inhibitorNon-inhibitor0.9759
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9577
Ames testNon AMES toxic0.5773
CarcinogenicityCarcinogens 0.8111
BiodegradationReady biodegradable0.943
Rat acute toxicity2.4160 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7988
hERG inhibition (predictor II)Non-inhibitor0.9446
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkaline earth metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkaline earth metal oxoanionic compounds
Sub Class
Alkaline earth metal sulfates
Direct Parent
Alkaline earth metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkaline earth metal sulfate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
magnesium salt, metal sulfate (CHEBI:32599)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only...
Gene Name
CACNG1
Uniprot ID
Q06432
Uniprot Name
Voltage-dependent calcium channel gamma-1 subunit
Molecular Weight
25028.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-...
Gene Name
CACNA2D1
Uniprot ID
P54289
Uniprot Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
Molecular Weight
124566.93 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1C
Uniprot ID
Q13936
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1C
Molecular Weight
248974.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB1
Uniprot ID
Q02641
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-1
Molecular Weight
65712.995 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB2
Uniprot ID
Q08289
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-2
Molecular Weight
73579.925 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1S
Uniprot ID
Q13698
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1S
Molecular Weight
212348.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Uesawa Y, Takeuchi T, Mohri K: Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. [PubMed:22039822]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:43