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Identification
NamePregabalin
Accession NumberDB00230  (APRD01198)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
DescriptionPregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]
Structure
Thumb
Synonyms
(S)-3-Isobutyl gaba
3-Isobutyl gaba
CI-1008
Lyrica
S-(+)-3-isobutylgaba
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-pregabalinCapsule200 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule75 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule225 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule100 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule300 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule25 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule150 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalinCapsule50 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Act PregabalinCapsule25 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule225 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule50 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule300 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule100 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Act PregabalinCapsule75 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule200 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Act PregabalinCapsule150 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Auro-pregabalinCapsule50 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule225 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule75 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule300 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule150 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule100 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule25 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule200 mgOralAuro Pharma IncNot applicableNot applicableCanada
Dom-pregabalinCapsule50 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule75 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule300 mgOralDominion PharmacalNot applicableNot applicableCanada
Dom-pregabalinCapsule150 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule25 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule225 mgOralDominion PharmacalNot applicableNot applicableCanada
Gd-pregabalinCapsule150 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalinCapsule25 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule225 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalinCapsule50 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule300 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule75 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Ipg-pregabalinCapsule225 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule75 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule300 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule100 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule25 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule150 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule50 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-pregabalinCapsule75 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule150 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule300 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule25 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule50 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
LyricaCapsule100 mg/1OralDIRECT RX2015-01-01Not applicableUs
LyricaCapsule300 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-06Not applicableUs
LyricaCapsule150 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralDispensing Solutions, Inc.2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralRebel Distributors Corp2004-12-30Not applicableUs
LyricaCapsule225 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralU.S. Pharmaceuticals2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralSTAT Rx USA LLC2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mgOralPfizer Canada Inc2005-07-18Not applicableCanada
LyricaCapsule100 mg/1OralA S Medication Solutions2004-12-30Not applicableUs
LyricaCapsule225 mg/1OralRebel Distributors Corp2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule200 mgOralPfizer Canada IncNot applicableNot applicableCanada
LyricaCapsule150 mg/1OralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralPhysicians Total Care, Inc.2006-11-01Not applicableUs
LyricaCapsule300 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule25 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaCapsule75 mg/1OralREMEDYREPACK INC.2016-08-16Not applicableUs
LyricaCapsule25 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-07-18Not applicableUs
LyricaCapsule25 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-09-27Not applicableUs
LyricaCapsule200 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralDispensing Solutions, Inc.2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaSolution20 mg/mLOralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule50 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
LyricaCapsule150 mgOralPfizer Canada Inc2005-07-18Not applicableCanada
LyricaCapsule150 mg/1OralA S Medication Solutions2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralSTAT Rx USA LLC2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralPhysicians Total Care, Inc.2006-08-29Not applicableUs
LyricaCapsule225 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule200 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaCapsule150 mg/1OralREMEDYREPACK INC.2016-08-16Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-06Not applicableUs
LyricaCapsule50 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralLake Erie Medical & Surgical Supply, DBA Quality Care Products, LLC2011-11-08Not applicableUs
LyricaCapsule100 mg/1OralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
LyricaCapsule25 mgOralPfizer Canada Inc2005-07-18Not applicableCanada
LyricaCapsule50 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaCapsule150 mg/1OralREMEDYREPACK INC.2013-02-21Not applicableUs
LyricaCapsule150 mg/1OralPhysicians Total Care, Inc.2005-10-19Not applicableUs
LyricaCapsule150 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule100 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule225 mgOralPfizer Canada Inc2009-11-18Not applicableCanada
LyricaCapsule50 mg/1OralSTAT Rx USA LLC2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralDIRECT RX2014-01-01Not applicableUs
LyricaCapsule150 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-02-10Not applicableUs
LyricaCapsule100 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule300 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-08-13Not applicableUs
LyricaCapsule75 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule100 mgOralPfizer Canada IncNot applicableNot applicableCanada
LyricaCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
LyricaCapsule50 mgOralPfizer Canada Inc2005-07-18Not applicableCanada
LyricaCapsule75 mg/1OralRebel Distributors Corp2005-06-10Not applicableUs
LyricaCapsule50 mg/1OralREMEDYREPACK INC.2008-08-14Not applicableUs
LyricaCapsule50 mg/1OralPhysicians Total Care, Inc.2005-12-20Not applicableUs
LyricaCapsule200 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule150 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralU.S. Pharmaceuticals2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions Llc2004-12-30Not applicableUs
LyricaCapsule300 mgOralPfizer Canada Inc2005-07-18Not applicableCanada
LyricaCapsule50 mg/1OralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Mar-pregabalinCapsule100 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule75 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule150 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule225 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule25 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule300 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule50 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mint-pregabalinCapsule25 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule100 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule50 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule200 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule75 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule225 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule150 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule300 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Myl-pregabalinCapsule75 mgOralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalinCapsule150 mgOralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalinCapsule300 mgOralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalinCapsule25 mgOralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalinCapsule225 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Myl-pregabalinCapsule50 mgOralMylan Pharmaceuticals Ulc2013-07-142016-05-20Canada
Mylan-pregabalinCapsule150 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalinCapsule300 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalinCapsule25 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalinCapsule225 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalinCapsule50 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalinCapsule75 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Pendo-pregabalinCapsule50 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-pregabalinCapsule150 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
PMS-pregabalinCapsule25 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule300 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule50 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule225 mgOralPharmascience Inc2013-02-19Not applicableCanada
PMS-pregabalinCapsule75 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule150 mgOralPharmascience Inc2013-02-14Not applicableCanada
PregabalinCapsule25 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule25 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule150 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule150 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule50 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule150 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule150 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule300 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule150 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule200 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule225 mgOralSanis Health IncNot applicableNot applicableCanada
PregabalinCapsule25 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule25 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule300 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule300 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule25 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule50 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule50 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule75 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule300 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule225 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule25 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule225 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule200 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule50 mg/1OralDIRECT RX2014-01-01Not applicableUs
PregabalinCapsule225 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule50 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule50 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule75 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule50 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule75 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule100 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule300 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule50 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule225 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule300 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule75 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule75 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule150 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule100 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule75 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
PregabalinCapsule150 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule25 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule75 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule300 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalin CapsulesCapsule50 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule200 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule75 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule225 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule100 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule300 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule150 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin CapsulesCapsule25 mgOralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer Limited2014-04-10Not applicableEu
Pregabalin-150Capsule150 mgOralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-225Capsule225 mgOralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-25Capsule25 mgOralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-300Capsule300 mgOralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-50Capsule50 mgOralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-75Capsule75 mgOralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Ran-pregabalinCapsule50 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule300 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule75 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule150 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule25 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule225 mgOralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ratio-pregabalinCapsule300 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule50 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule100 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule75 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule200 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule150 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule25 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalinCapsule225 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Riva-pregabalinCapsule300 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule25 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule225 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-pregabalinCapsule50 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule75 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule150 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Sandoz PregabalinCapsule150 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule25 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule300 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule50 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule75 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Teva-pregabalinCapsule75 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule200 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Teva-pregabalinCapsule150 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule25 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule225 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule50 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule300 mgOralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalinCapsule100 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule50 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule200 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule75 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule225 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule100 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule300 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule25 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule150 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-pregabalinCapsule25 mgOralApotex Inc2013-06-06Not applicableCanada
Apo-pregabalinCapsule225 mgOralApotex Inc2013-05-09Not applicableCanada
Apo-pregabalinCapsule50 mgOralApotex Inc2013-06-06Not applicableCanada
Apo-pregabalinCapsule300 mgOralApotex Inc2013-04-22Not applicableCanada
Apo-pregabalinCapsule75 mgOralApotex Inc2013-04-22Not applicableCanada
Apo-pregabalinCapsule150 mgOralApotex Inc2013-04-22Not applicableCanada
LyricaCapsule150 mg/1OralDIRECT RX2014-01-01Not applicableUs
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII55JG375S6M
CAS number148553-50-8
WeightAverage: 159.2261
Monoisotopic: 159.125928793
Chemical FormulaC8H17NO2
InChI KeyAYXYPKUFHZROOJ-ZETCQYMHSA-N
InChI
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
IUPAC Name
(3S)-3-(aminomethyl)-5-methylhexanoic acid
SMILES
CC(C)C[[email protected]](CN)CC(O)=O
Pharmacology
IndicationPregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is also used as adjunctive therapy for adult patients with partial onset seizures and management of fibromyalgia.
Structured Indications
PharmacodynamicsPregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Mechanism of actionPregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. Studies also suggest that the descending noradrenergic and serotonergic pathways originating from the brainstem may be involved with the mechanism of pregabalin. Interestingly, although pregabalin is a structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors. The sodium channels, opiate receptors, and cyclooxygenase enzymes are not involved with the mechanism of pregabalin. It is also inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
TargetKindPharmacological actionActionsOrganismUniProt ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1AProteinyes
inhibitor
HumanO00555 details
Related Articles
AbsorptionPregabalin is well absorbed after oral administration. When an oral administration of pregabalin under fasting conditions is given, the pharmacokinetic parameters are as follows: Tmax = 1.5 hours; Oral bioavailability = >90% (independent of dose); Time to steady state = 24-48 hours. It is also a substrate for the L-type transport system.
Volume of distribution

Apparent volume of distribution, oral administration = 0.5 L/kg.
Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.

Protein bindingPregabalin does not bind to plasma proteins.
Metabolism

Pregabalin undergoes negligible metabolism in humans.

Route of elimination90% of the dose was recovered in the urine as the parent compound. The N-methylated derivative of pregabalin, the major metabolite was found in the urine and accounted for 0.9% of the dose. Pregabalin (S-enantiomer) did not undergo racemization to the R-enantiomer.
Half life6.3 hours
Clearance

Renal clearance, healthy subjects = 67.0 – 80.9 mL/min. Because pregabalin is not bound to plasma protein, this rate suggests the involvement of renal tubular reabsorption.

ToxicityMost common adverse reactions (≥5% and twice placebo) are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain and thinking abnormal (primarily difficulty with concentration/attention).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Pregabalin.Experimental
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Pregabalin.Vet Approved
7-NitroindazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfentanil.Approved, Illicit
AlfuzosinAlfuzosin may increase the hypotensive activities of Pregabalin.Approved, Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alprazolam.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amobarbital.Approved, Illicit
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Pregabalin.Approved
AmoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amperozide.Experimental
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Pregabalin.Approved, Investigational
AN2690The risk or severity of adverse effects can be increased when AN2690 is combined with Pregabalin.Investigational
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Pregabalin.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aripiprazole.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Pregabalin.Approved
ArticaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Asenapine.Approved
AtosibanThe risk or severity of adverse effects can be increased when Pregabalin is combined with Atosiban.Approved
Atracurium besylatePregabalin may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Azaperone.Vet Approved
AzelastinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Baclofen.Approved
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Pregabalin.Experimental
BarbexacloneThe metabolism of Pregabalin can be increased when combined with Barbexaclone.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Barbital.Illicit
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Pregabalin.Approved, Investigational
BenperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzocaine.Approved
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Pregabalin.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzyl alcohol.Approved
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Pregabalin.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
BromazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brotizolam.Approved, Withdrawn
BucindololBucindolol may increase the hypotensive activities of Pregabalin.Investigational
BupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bupivacaine.Approved, Investigational
BuprenorphinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butabarbital.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butamben.Approved
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Pregabalin.Approved
ButethalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butethal.Approved, Illicit
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Pregabalin.Approved
ButorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butorphanol.Approved, Illicit, Vet Approved
CalciumThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium.Nutraceutical
Calcium AcetateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Acetate.Approved
Calcium carbonateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium carbonate.Approved
Calcium ChlorideThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Chloride.Approved
Calcium citrateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium citrate.Approved
Calcium glubionateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Pregabalin.Withdrawn
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Pregabalin.Experimental
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Pregabalin.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbinoxamine.Approved
CarbomycinThe metabolism of Pregabalin can be decreased when combined with Carbomycin.Vet Approved
CarfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carisoprodol.Approved
CarvedilolCarvedilol may increase the hypotensive activities of Pregabalin.Approved, Investigational
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Pregabalin.Approved
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Pregabalin.Approved
CetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlordiazepoxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloroprocaine.Approved
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Pregabalin.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorzoxazone.Approved
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Pregabalin.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Pregabalin.Approved
CimetidineThe serum concentration of Pregabalin can be increased when it is combined with Cimetidine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Citalopram.Approved
ClarithromycinThe metabolism of Pregabalin can be decreased when combined with Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonidine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Pregabalin.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clorazepate.Approved, Illicit
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pregabalin.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clozapine.Approved
CocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Codeine.Approved, Illicit
CordycepinThe risk or severity of adverse effects can be increased when Cordycepin is combined with Pregabalin.Investigational
CyclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclobenzaprine.Approved
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Pregabalin.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dapiprazole.Approved
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Pregabalin.Investigational
Decanoic AcidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Pregabalin.Experimental
deramciclaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desflurane.Approved
DesipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diazepam.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenoxylate.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doramectin.Vet Approved
DoxazosinDoxazosin may increase the hypotensive activities of Pregabalin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Pregabalin is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Pregabalin is combined with ECGONINE METHYL ESTER.Experimental
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Pregabalin.Approved
EcopipamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Pregabalin can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Pregabalin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Pregabalin.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Pregabalin.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Pregabalin.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Entacapone.Approved, Investigational
ErythromycinThe metabolism of Pregabalin can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Eszopiclone.Approved
EthanolPregabalin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Pregabalin.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flibanserin.Approved
FluconazoleThe serum concentration of Pregabalin can be increased when it is combined with Fluconazole.Approved
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Pregabalin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Pregabalin.Approved, Investigational
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Pregabalin.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Pregabalin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gabapentin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Pregabalin is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.Approved, Illicit
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Pregabalin.Experimental
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Pregabalin.Approved, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Haloperidol.Approved
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Pregabalin.Approved, Withdrawn
HalothaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Heroin.Approved, Illicit
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Pregabalin.Approved
HexobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hexobarbital.Approved
HydrocodonePregabalin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hydromorphone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Iloperidone.Approved
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Pregabalin.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Indalpine.Investigational, Withdrawn
IndoraminIndoramin may increase the hypotensive activities of Pregabalin.Withdrawn
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Pregabalin.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Isoflurane.Approved, Vet Approved
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Pregabalin.Approved, Investigational
JosamycinThe metabolism of Pregabalin can be decreased when combined with Josamycin.Approved
KetamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketobemidone.Approved
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pregabalin.Approved, Investigational
KitasamycinThe metabolism of Pregabalin can be decreased when combined with Kitasamycin.Experimental
LabetalolLabetalol may increase the hypotensive activities of Pregabalin.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levorphanol.Approved
LidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lidocaine.Approved, Vet Approved
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pregabalin.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregabalin.Approved
LoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loxapine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Pregabalin is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lurasidone.Approved
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium hydroxide.Approved
Magnesium oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium salicylate.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Medetomidine.Vet Approved
MefloquineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meprobamate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methohexital.Approved
MethotrimeprazinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methylphenobarbital.Approved
MetyrosinePregabalin may increase the sedative activities of Metyrosine.Approved
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Pregabalin.Experimental
MianserinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mianserin.Approved
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Pregabalin.Approved, Investigational
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Pregabalin.Approved, Investigational, Vet Approved
MidazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Midazolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Milnacipran.Approved
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Pregabalin.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Investigational
MirtazapinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumPregabalin may increase the neuromuscular blocking activities of Mivacurium.Approved
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Pregabalin.Approved
MolindoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Molindone.Approved
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Pregabalin.Vet Approved
MorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Morphine.Approved, Investigational
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Pregabalin.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Investigational
NafcillinThe metabolism of Pregabalin can be increased when combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Pregabalin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nalbuphine.Approved
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Pregabalin.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrazepam.Approved
NitroprussidePregabalin may increase the hypotensive activities of Nitroprusside.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrous oxide.Approved, Vet Approved
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Pregabalin.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nortriptyline.Approved
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Pregabalin.Approved, Vet Approved
OlanzapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olanzapine.Approved, Investigational
OleandomycinThe metabolism of Pregabalin can be decreased when combined with Oleandomycin.Vet Approved
OlopatadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olopatadine.Approved
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Pregabalin.Investigational
OndansetronThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of Pregabalin can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Pregabalin is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxetacaine.Investigational
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Pregabalin.Approved
OxprenololThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxymorphone.Approved, Investigational, Vet Approved
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Pregabalin.Investigational
PaliperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paliperidone.Approved
ParaldehydePregabalin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paroxetine.Approved, Investigational
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Pregabalin.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
PerazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perazine.Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Pregabalin.Approved
PerospironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perphenazine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pethidine.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenoxyethanol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Pregabalin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pimozide.Approved
PioglitazonePregabalin may increase the fluid retaining activities of Pioglitazone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pomalidomide.Approved
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Pregabalin.Approved, Investigational, Vet Approved
PramipexolePregabalin may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prazepam.Approved, Illicit
PrazosinPrazosin may increase the hypotensive activities of Pregabalin.Approved
PregnanoloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prilocaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prochlorperazine.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propofol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Pregabalin is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quetiapine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Pregabalin.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Raclopride.Investigational
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Pregabalin.Experimental
RamelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ramelteon.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Pregabalin.Approved
RapacuroniumPregabalin may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RemifentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remoxipride.Approved, Withdrawn
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Pregabalin.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Pregabalin.Approved
RifabutinThe serum concentration of Pregabalin can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Pregabalin can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Pregabalin can be decreased when it is combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Romifidine.Vet Approved
RopinirolePregabalin may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ropivacaine.Approved
RosiglitazonePregabalin may increase the fluid retaining activities of Rosiglitazone.Approved, Investigational
RotigotinePregabalin may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Pregabalin.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Pregabalin is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Pregabalin is combined with Sage 547.Investigational
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Pregabalin.Experimental
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Pregabalin.Approved, Vet Approved
ScopolamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Secobarbital.Approved, Vet Approved
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Pregabalin.Approved
SertindoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sevoflurane.Approved, Vet Approved
SilodosinSilodosin may increase the hypotensive activities of Pregabalin.Approved
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Pregabalin.Experimental
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Pregabalin.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
SolithromycinThe metabolism of Pregabalin can be decreased when combined with Solithromycin.Investigational
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Pregabalin.Approved
StiripentolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sufentanil.Approved, Investigational
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Pregabalin.Approved
SulpirideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sulpiride.Approved
SuvorexantPregabalin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TamsulosinTamsulosin may increase the hypotensive activities of Pregabalin.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tasimelteon.Approved
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Pregabalin.Approved
TelithromycinThe metabolism of Pregabalin can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Temazepam.Approved
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Pregabalin.Experimental, Investigational
TerazosinTerazosin may increase the hypotensive activities of Pregabalin.Approved
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Pregabalin.Approved, Investigational, Vet Approved
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Pregabalin.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrodotoxin.Investigational
ThalidomidePregabalin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thioridazine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiothixene.Approved
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Pregabalin.Approved
TiagabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiletamine.Vet Approved
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Pregabalin.Approved
TizanidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tolcapone.Approved, Withdrawn
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Pregabalin.Approved, Vet Approved
TopiramateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Pregabalin.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Pregabalin.Approved
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trifluoperazine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triflupromazine.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Pregabalin.Experimental
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Pregabalin.Approved, Investigational
TrimipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triprolidine.Approved
TroglitazonePregabalin may increase the fluid retaining activities of Troglitazone.Withdrawn
TroleandomycinThe metabolism of Pregabalin can be decreased when combined with Troleandomycin.Approved
TylosinThe metabolism of Pregabalin can be decreased when combined with Tylosin.Vet Approved
Uc1010The risk or severity of adverse effects can be increased when Pregabalin is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Valproic Acid.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vigabatrin.Approved
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Pregabalin.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zolazepam.Vet Approved
ZolpidemPregabalin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol (may increase CNS effects).
  • When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
References
Synthesis Reference

Mark Burk, “Asymmetric synthesis of pregabalin.” U.S. Patent US20030212290, issued November 13, 2003.

US20030212290
General References
  1. Authors unspecified: Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Fed Regist. 2005 Jul 28;70(144):43633-5. [PubMed:16050051 ]
  2. Su TZ, Feng MR, Weber ML: Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells. J Pharmacol Exp Ther. 2005 Jun;313(3):1406-15. Epub 2005 Mar 15. [PubMed:15769862 ]
  3. Li Z, Taylor CP, Weber M, Piechan J, Prior F, Bian F, Cui M, Hoffman D, Donevan S: Pregabalin is a potent and selective ligand for alpha(2)delta-1 and alpha(2)delta-2 calcium channel subunits. Eur J Pharmacol. 2011 Sep 30;667(1-3):80-90. doi: 10.1016/j.ejphar.2011.05.054. Epub 2011 Jun 1. [PubMed:21651903 ]
External Links
ATC CodesN03AX16
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.46 MB)
MSDSDownload (106 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9727
Blood Brain Barrier+0.9382
Caco-2 permeable-0.6531
P-glycoprotein substrateNon-substrate0.683
P-glycoprotein inhibitor INon-inhibitor0.965
P-glycoprotein inhibitor IINon-inhibitor0.9424
Renal organic cation transporterNon-inhibitor0.9245
CYP450 2C9 substrateNon-substrate0.8758
CYP450 2D6 substrateNon-substrate0.7926
CYP450 3A4 substrateNon-substrate0.6914
CYP450 1A2 substrateNon-inhibitor0.9385
CYP450 2C9 inhibitorNon-inhibitor0.9425
CYP450 2D6 inhibitorNon-inhibitor0.9539
CYP450 2C19 inhibitorNon-inhibitor0.9629
CYP450 3A4 inhibitorNon-inhibitor0.9352
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9784
Ames testNon AMES toxic0.938
CarcinogenicityNon-carcinogens0.5678
BiodegradationReady biodegradable0.8201
Rat acute toxicity1.7046 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9868
hERG inhibition (predictor II)Non-inhibitor0.8909
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
CapsuleOral100 mg
CapsuleOral100 mg/1
CapsuleOral150 mg/1
CapsuleOral150 mg
CapsuleOral200 mg/1
CapsuleOral200 mg
CapsuleOral225 mg/1
CapsuleOral225 mg
CapsuleOral25 mg/1
CapsuleOral25 mg
CapsuleOral300 mg/1
CapsuleOral300 mg
CapsuleOral50 mg/1
CapsuleOral50 mg
CapsuleOral75 mg
CapsuleOral75 mg/1
SolutionOral20 mg/mL
Prices
Unit descriptionCostUnit
Lyrica 100 mg capsule2.88USD capsule
Lyrica 150 mg capsule2.88USD capsule
Lyrica 50 mg capsule2.88USD capsule
Lyrica 75 mg capsule2.88USD capsule
Lyrica 200 mg capsule2.75USD capsule
Lyrica 225 mg capsule2.75USD capsule
Lyrica 25 mg capsule2.75USD capsule
Lyrica 300 mg capsule2.75USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2297163 No2001-11-202018-08-18Canada
CA2327285 No2005-06-142019-05-10Canada
US5563175 No1993-10-082013-10-08Us
US6001876 No1998-12-302018-12-30Us
US6197819 No1998-12-302018-12-30Us
USRE41920 No1998-12-302018-12-30Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityFreely soluble FDA label
logP-1.35FDA label
pKa4.2 and 10.6 FDA label
Predicted Properties
PropertyValueSource
Water Solubility11.3 mg/mLALOGPS
logP-1.4ALOGPS
logP-1.3ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)4.8ChemAxon
pKa (Strongest Basic)10.23ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity43.68 m3·mol-1ChemAxon
Polarizability18.08 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGamma amino acids and derivatives
Alternative Parents
Substituents
  • Gamma amino acid or derivatives
  • Medium-chain fatty acid
  • Branched fatty acid
  • Amino fatty acid
  • Fatty acyl
  • Fatty acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to...
Gene Name:
CACNA1A
Uniprot ID:
O00555
Molecular Weight:
282362.39 Da
References
  1. Gazulla J, Tintore M: The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6. Acta Neurol Scand. 2007 May;115(5):356-63. [PubMed:17489948 ]
  2. Gazulla J, Tintore MA: The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit. Med Hypotheses. 2007;68(1):131-6. Epub 2006 Aug 8. [PubMed:16899342 ]
  3. Jacquy J, Lossignol D, Sternon J: [Pregabalin (Lyrica) and neuropathic pain syndromes]. Rev Med Brux. 2006 Sep-Oct;27(5):445-50. [PubMed:17144644 ]
  4. Taylor CP, Angelotti T, Fauman E: Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007 Feb;73(2):137-50. Epub 2006 Nov 28. [PubMed:17126531 ]
  5. Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su TZ, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T, Williams D: Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17537-42. Epub 2006 Nov 6. [PubMed:17088553 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
Other
General Function:
Sodium:dicarboxylate symporter activity
Specific Function:
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Gene Name:
SLC1A1
Uniprot ID:
P43005
Molecular Weight:
57099.835 Da
References
  1. Ryu JH, Lee PB, Kim JH, Do SH, Kim CS: Effects of pregabalin on the activity of glutamate transporter type 3. Br J Anaesth. 2012 Aug;109(2):234-9. doi: 10.1093/bja/aes120. Epub 2012 Apr 16. [PubMed:22511482 ]
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Drug created on June 13, 2005 07:24 / Updated on December 04, 2016 02:43