Identification
NamePregabalin
Accession NumberDB00230  (APRD01198)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
Description

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]

Structure
Thumb
Synonyms
(S)-3-Isobutyl gaba
3-Isobutyl gaba
Lyrica
S-(+)-3-isobutylgaba
External IDs CI-1008
Product Ingredients Not Available
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-pregabalinCapsule150 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule300 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule75 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule200 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule25 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule100 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule225 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-pregabalinCapsule50 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Act PregabalinCapsule50 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule25 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule200 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Act PregabalinCapsule225 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule75 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule300 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Act PregabalinCapsule100 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Act PregabalinCapsule150 mgOralActavis Pharma Company2013-03-06Not applicableCanada
Auro-pregabalinCapsule100 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule75 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule150 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule300 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule25 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalinCapsule200 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule225 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalinCapsule50 mgOralAuro Pharma Inc2015-03-02Not applicableCanada
Dom-pregabalinCapsule75 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule225 mgOralDominion PharmacalNot applicableNot applicableCanada
Dom-pregabalinCapsule50 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule150 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalinCapsule300 mgOralDominion PharmacalNot applicableNot applicableCanada
Dom-pregabalinCapsule25 mgOralDominion Pharmacal2013-09-09Not applicableCanada
Gd-pregabalinCapsule75 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalinCapsule50 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule300 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule150 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalinCapsule25 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalinCapsule225 mgOralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Ipg-pregabalinCapsule150 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule25 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule300 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule100 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule50 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule225 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalinCapsule75 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-pregabalinCapsule150 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule75 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule300 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule25 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalinCapsule50 mgOralJamp Pharma Corporation2015-09-28Not applicableCanada
LyricaCapsule200 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2011-11-08Not applicableUs
LyricaCapsule50 mg/1OralStat Rx USA2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule100 mgOralPfizerNot applicableNot applicableCanada
LyricaCapsule200 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralStat Rx USA2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralUnit Dose Services2004-12-30Not applicableUs00071 1015 68 nlmimage10 5215a92d
LyricaCapsule50 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralDirectrx2014-01-01Not applicableUs
LyricaCapsule100 mg/1OralH.J. Harkins Company2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2011-07-18Not applicableUs
LyricaCapsule100 mg/1OralRemedy Repack2016-08-30Not applicableUs
LyricaCapsule150 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralRemedy Repack2008-09-262017-07-15Us
LyricaCapsule225 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs00071 1019 68 nlmimage10 4f15a7ad
LyricaCapsule200 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs00071 1017 68 nlmimage10 5515aaad
LyricaCapsule75 mg/1OralRemedy Repack2017-07-13Not applicableUs
LyricaCapsule25 mgOralPfizer2005-07-18Not applicableCanada
LyricaCapsule150 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule200 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-09-27Not applicableUs
LyricaCapsule75 mg/1OralDispensing Solutions, Inc.2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule150 mgOralPfizer2005-07-18Not applicableCanada
LyricaSolution20 mg/mLOralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule75 mg/1OralRebel Distributors2005-06-10Not applicableUs
LyricaCapsule150 mg/1OralDirectrx2014-01-01Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule75 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralSt. Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule150 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralH.J. Harkins Company2004-12-30Not applicableUs
LyricaCapsule225 mg/1OralRebel Distributors2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralRemedy Repack2016-08-16Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule200 mg/1OralRebel Distributors2005-06-10Not applicableUs
LyricaCapsule75 mg/1OralPhysicians Total Care, Inc.2006-11-01Not applicableUs00071 1014 68 nlmimage10 5715abfd
LyricaCapsule50 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
LyricaCapsule100 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions2004-12-302017-06-20Us00071 1013 68 nlmimage10 5115a8fd
LyricaCapsule50 mgOralPfizer2005-07-18Not applicableCanada
LyricaCapsule300 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule25 mg/1OralRebel Distributors2005-06-10Not applicableUs
LyricaCapsule100 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule200 mgOralPfizerNot applicableNot applicableCanada
LyricaCapsule50 mg/1OralStat Rx USA2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralSt. Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule75 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralDirectrx2015-01-01Not applicableUs
LyricaCapsule75 mg/1OralH.J. Harkins Company2004-12-30Not applicableUs
LyricaCapsule150 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2012-02-06Not applicableUs
LyricaCapsule50 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs00071 1018 68 nlmimage10 5815ac2d
LyricaCapsule75 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2011-02-10Not applicableUs
LyricaCapsule300 mg/1Oralbryant ranch prepack2004-12-302017-06-20Us
LyricaCapsule200 mg/1OralRemedy Repack2017-07-13Not applicableUs
LyricaCapsule225 mgOralPfizer2009-11-18Not applicableCanada
LyricaCapsule150 mg/1OralRemedy Repack2013-02-21Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule100 mg/1OralRebel Distributors2005-06-10Not applicableUs
LyricaCapsule150 mg/1OralPhysicians Total Care, Inc.2005-10-19Not applicableUs
LyricaCapsule100 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralU.S. Pharmaceuticals2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs00071 1012 68 nlmimage10 c63be31f
LyricaCapsule150 mg/1OralRemedy Repack2016-08-16Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule300 mg/1OralRebel Distributors2004-12-30Not applicableUs
LyricaCapsule225 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2017-01-20Not applicableUs
LyricaCapsule25 mg/1OralPhysicians Total Care, Inc.2006-08-29Not applicableUs
LyricaCapsule150 mg/1Oralbryant ranch prepack2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
LyricaCapsule25 mg/1Oralbryant ranch prepack2004-12-302017-06-20Us
LyricaCapsule100 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule75 mgOralPfizer2005-07-18Not applicableCanada
LyricaCapsule225 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule50 mg/1OralRebel Distributors2005-06-10Not applicableUs
LyricaCapsule150 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule50 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
LyricaCapsule200 mg/1OralSt. Marys Medical Park Pharmacy2010-12-31Not applicableUs
LyricaCapsule100 mg/1OralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
LyricaCapsule25 mg/1OralCardinal Health2004-12-30Not applicableUs
LyricaCapsule50 mg/1OralH.J. Harkins Company2004-12-30Not applicableUs
LyricaCapsule300 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-08-13Not applicableUs
LyricaCapsule25 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
LyricaCapsule100 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2012-02-06Not applicableUs
LyricaCapsule150 mg/1OralDispensing Solutions, Inc.2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralUnit Dose Services2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralU.S. Pharmaceuticals2004-12-30Not applicableUs
LyricaCapsule75 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule300 mgOralPfizer2005-07-18Not applicableCanada
LyricaCapsule50 mg/1OralRemedy Repack2008-08-14Not applicableUs
LyricaCapsule100 mg/1OralA S Medication Solutions2004-12-302017-06-20Us
LyricaCapsule150 mg/1OralRebel Distributors2005-06-10Not applicableUs00071 1016 68 nlmimage10 5a15ad7d
LyricaCapsule50 mg/1OralPhysicians Total Care, Inc.2005-12-20Not applicableUs
LyricaCapsule150 mg/1OralAphena Pharma Solutions Tennessee, Inc.2004-12-30Not applicableUs
Mar-pregabalinCapsule50 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule300 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule75 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule25 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule225 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalinCapsule150 mgOralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalinCapsule100 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule300 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule25 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule225 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule150 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule50 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule100 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalinCapsule75 mgOralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalinCapsule200 mgOralMint Pharmaceuticals IncNot applicableNot applicableCanada
Myl-pregabalinCapsule150 mgOralMylan Pharmaceuticals2013-07-242016-05-20Canada
Myl-pregabalinCapsule75 mgOralMylan Pharmaceuticals2013-07-242016-05-20Canada
Myl-pregabalinCapsule25 mgOralMylan Pharmaceuticals2013-07-242016-05-20Canada
Myl-pregabalinCapsule300 mgOralMylan Pharmaceuticals2013-07-242016-05-20Canada
Myl-pregabalinCapsule50 mgOralMylan Pharmaceuticals2013-07-142016-05-20Canada
Myl-pregabalinCapsule225 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule50 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule300 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule75 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule25 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule225 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Mylan-pregabalinCapsule150 mgOralMylan PharmaceuticalsNot applicableNot applicableCanada
Pendo-pregabalinCapsule50 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-pregabalinCapsule150 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
PMS-pregabalinCapsule75 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule25 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule150 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule225 mgOralPharmascience Inc2013-02-19Not applicableCanada
PMS-pregabalinCapsule50 mgOralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalinCapsule300 mgOralPharmascience Inc2013-02-14Not applicableCanada
PregabalinCapsule50 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule300 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule25 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule225 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule25 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule100 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule150 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule25 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule50 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule225 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule50 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule25 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule75 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule300 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule150 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule225 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule150 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule75 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule225 mgOralSivem Pharmaceuticals Ulc2013-03-272016-11-29Canada
PregabalinCapsule50 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule300 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule50 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule225 mgOralSanis Health IncNot applicableNot applicableCanada
PregabalinCapsule150 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule300 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule50 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule25 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule75 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule300 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule75 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule150 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule200 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule300 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule300 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule25 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
PregabalinCapsule50 mg/1OralDirectrx2014-01-01Not applicableUs
PregabalinCapsule150 mgOralRanbaxy Inc.Not applicableNot applicableCanada
PregabalinCapsule25 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule75 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule75 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
PregabalinCapsule100 mgOralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
PregabalinCapsule200 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
PregabalinCapsule75 mgOralSanis Health Inc2013-06-12Not applicableCanada
PregabalinCapsule50 mgOralPro Doc Limitee2013-02-15Not applicableCanada
PregabalinCapsule150 mgOralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalin CapsulesCapsule200 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule25 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule100 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule225 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule50 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule150 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule300 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin CapsulesCapsule75 mgOralLupin PharmaceuticalsNot applicableNot applicableCanada
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule150 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule50 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule100 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule225 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule25 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule75 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule200 mgOralPfizer2014-04-10Not applicableEu
Pregabalin PfizerCapsule300 mgOralPfizer2014-04-10Not applicableEu
Pregabalin-150Capsule150 mgOralSivem Pharmaceuticals Ulc2013-10-232014-10-07Canada
Pregabalin-225Capsule225 mgOralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-25Capsule25 mgOralSivem Pharmaceuticals Ulc2013-10-232014-11-06Canada
Pregabalin-300Capsule300 mgOralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-50Capsule50 mgOralSivem Pharmaceuticals Ulc2013-10-232014-11-20Canada
Pregabalin-75Capsule75 mgOralSivem Pharmaceuticals Ulc2013-10-232014-09-29Canada
Ran-pregabalinCapsule25 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule150 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule50 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule225 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule75 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ran-pregabalinCapsule300 mgOralRanbaxy Inc.2013-02-15Not applicableCanada
Ratio-pregabalinCapsule150 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule225 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule50 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule100 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule300 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule75 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule200 mgOralTevaNot applicableNot applicableCanada
Ratio-pregabalinCapsule25 mgOralTevaNot applicableNot applicableCanada
Riva-pregabalinCapsule150 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule50 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule300 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule225 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-pregabalinCapsule75 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalinCapsule25 mgOralLaboratoire Riva Inc2013-02-15Not applicableCanada
Sandoz PregabalinCapsule75 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule50 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule150 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule300 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz PregabalinCapsule25 mgOralSandoz Canada Incorporated2013-02-15Not applicableCanada
Teva-pregabalinCapsule50 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule225 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule25 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule75 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule100 mgOralTevaNot applicableNot applicableCanada
Teva-pregabalinCapsule300 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule150 mgOralTeva2013-02-15Not applicableCanada
Teva-pregabalinCapsule200 mgOralTevaNot applicableNot applicableCanada
Torrent-pregabalinCapsule200 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule50 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule150 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule225 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule75 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule25 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule300 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalinCapsule100 mgOralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-pregabalinCapsule25 mgOralApotex Corporation2013-06-06Not applicableCanada
Apo-pregabalinCapsule150 mgOralApotex Corporation2013-04-22Not applicableCanada
Apo-pregabalinCapsule50 mgOralApotex Corporation2013-06-06Not applicableCanada
Apo-pregabalinCapsule225 mgOralApotex Corporation2013-05-09Not applicableCanada
Apo-pregabalinCapsule75 mgOralApotex Corporation2013-04-22Not applicableCanada
Apo-pregabalinCapsule300 mgOralApotex Corporation2013-04-22Not applicableCanada
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule25 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule150 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule200 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule225 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule300 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule75 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule100 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule50 mgOralAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin MylanCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule50 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule100 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule200 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule300 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule25 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule75 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule150 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule225 mgOralInternational Pharmaceutical Generics Ltd2015-06-25Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule150 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule225 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule50 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule200 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule75 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule25 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule100 mgOralZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule300 mgOralZentiva, K.S.2015-07-17Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNII55JG375S6M
CAS number148553-50-8
WeightAverage: 159.2261
Monoisotopic: 159.125928793
Chemical FormulaC8H17NO2
InChI KeyAYXYPKUFHZROOJ-ZETCQYMHSA-N
InChI
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
IUPAC Name
(3S)-3-(aminomethyl)-5-methylhexanoic acid
SMILES
CC(C)C[[email protected]](CN)CC(O)=O
Pharmacology
Indication

Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is also used as adjunctive therapy for adult patients with partial onset seizures and management of fibromyalgia.

Structured Indications
Pharmacodynamics

Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Mechanism of action

Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. Studies also suggest that the descending noradrenergic and serotonergic pathways originating from the brainstem may be involved with the mechanism of pregabalin. Interestingly, although pregabalin is a structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors. The sodium channels, opiate receptors, and cyclooxygenase enzymes are not involved with the mechanism of pregabalin. It is also inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

TargetKindPharmacological actionActionsOrganismUniProt ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1AProteinyes
inhibitor
HumanO00555 details
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Absorption

Pregabalin is well absorbed after oral administration. When an oral administration of pregabalin under fasting conditions is given, the pharmacokinetic parameters are as follows: Tmax = 1.5 hours; Oral bioavailability = >90% (independent of dose); Time to steady state = 24-48 hours.
It is also a substrate for the L-type transport system.

Volume of distribution

Apparent volume of distribution, oral administration = 0.5 L/kg. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.

Protein binding

Pregabalin does not bind to plasma proteins.

Metabolism

Pregabalin undergoes negligible metabolism in humans.

Route of elimination

90% of the dose was recovered in the urine as the parent compound. The N-methylated derivative of pregabalin, the major metabolite was found in the urine and accounted for 0.9% of the dose. Pregabalin (S-enantiomer) did not undergo racemization to the R-enantiomer.

Half life

6.3 hours

Clearance

Renal clearance, healthy subjects = 67.0 - 80.9 mL/min. Because pregabalin is not bound to plasma protein, this rate suggests the involvement of renal tubular reabsorption.

Toxicity

Most common adverse reactions (≥5% and twice placebo) are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain and thinking abnormal (primarily difficulty with concentration/attention).

Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Pregabalin.Experimental
7-NitroindazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aceprometazine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfentanil.Approved, Illicit
AlfuzosinAlfuzosin may increase the hypotensive activities of Pregabalin.Approved, Investigational
AllopregnanoloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sage 547.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alprazolam.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amperozide.Experimental
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Pregabalin.Approved, Investigational
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Pregabalin.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aripiprazole.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Pregabalin.Approved
ArticaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Asenapine.Approved
Atracurium besylatePregabalin may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzelastinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Baclofen.Approved
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Pregabalin.Experimental
BarbexacloneThe metabolism of Pregabalin can be increased when combined with Barbexaclone.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Barbital.Illicit
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Pregabalin.Approved, Investigational
BenperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzocaine.Approved
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Pregabalin.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzyl alcohol.Approved
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Pregabalin.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
BromazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brotizolam.Approved, Withdrawn
BucindololBucindolol may increase the hypotensive activities of Pregabalin.Investigational
BupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bupivacaine.Approved, Investigational
BuprenorphinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butabarbital.Approved, Illicit
ButalbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butalbital.Approved, Illicit
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Pregabalin.Approved
ButethalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butethal.Approved, Illicit
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Pregabalin.Approved
ButorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butorphanol.Approved, Illicit, Vet Approved
CalciumThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium.Nutraceutical
Calcium AcetateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Acetate.Approved
Calcium CarbonateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium carbonate.Approved
Calcium ChlorideThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium citrate.Approved
Calcium glubionateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Pregabalin.Withdrawn
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Pregabalin.Experimental
Capric acidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Pregabalin.Experimental
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Pregabalin.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carisoprodol.Approved
CarvedilolCarvedilol may increase the hypotensive activities of Pregabalin.Approved, Investigational
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Pregabalin.Approved
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Pregabalin.Approved
CetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlordiazepoxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloroprocaine.Approved
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Pregabalin.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorzoxazone.Approved
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Pregabalin.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Pregabalin.Approved
CimetidineThe serum concentration of Pregabalin can be increased when it is combined with Cimetidine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Citalopram.Approved
ClarithromycinThe metabolism of Pregabalin can be decreased when combined with Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clobazam.Approved, Illicit
ClomipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonidine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Pregabalin.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clorazepate.Approved, Illicit
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pregabalin.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clozapine.Approved
CocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Codeine.Approved, Illicit
CordycepinThe risk or severity of adverse effects can be increased when Cordycepin is combined with Pregabalin.Investigational
CyclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclobenzaprine.Approved
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Pregabalin.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dapiprazole.Approved
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Pregabalin.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desflurane.Approved
DesipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desvenlafaxine.Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diazepam.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenoxylate.Approved, Illicit
DoxazosinDoxazosin may increase the hypotensive activities of Pregabalin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ecgonine.Experimental, Illicit
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Pregabalin.Approved
EcopipamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Pregabalin can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Pregabalin.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pregnanolone.Investigational
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Pregabalin.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Pregabalin.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Pregabalin.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Entacapone.Approved, Investigational
ErythromycinThe metabolism of Pregabalin can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Eszopiclone.Approved
EthanolPregabalin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Pregabalin.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flibanserin.Approved
FluconazoleThe serum concentration of Pregabalin can be increased when it is combined with Fluconazole.Approved
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Pregabalin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluspirilene.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Pregabalin.Approved, Investigational
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Pregabalin.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Pregabalin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gabapentin.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Pregabalin is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.Approved, Illicit
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Pregabalin.Experimental
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Pregabalin.Approved, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Haloperidol.Approved
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Pregabalin.Approved, Withdrawn
HalothaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Heroin.Approved, Illicit
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Pregabalin.Approved
HexobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hexobarbital.Approved
HydrocodonePregabalin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hydromorphone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Iloperidone.Approved
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Pregabalin.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Indalpine.Investigational, Withdrawn
IndoraminIndoramin may increase the hypotensive activities of Pregabalin.Withdrawn
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Pregabalin.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Isoflurane.Approved, Vet Approved
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Pregabalin.Approved, Investigational
JosamycinThe metabolism of Pregabalin can be decreased when combined with Josamycin.Approved
KetamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketobemidone.Approved
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pregabalin.Approved, Investigational
KitasamycinThe metabolism of Pregabalin can be decreased when combined with Kitasamycin.Experimental
LabetalolLabetalol may increase the hypotensive activities of Pregabalin.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levorphanol.Approved
LidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lidocaine.Approved, Vet Approved
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pregabalin.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregabalin.Approved
LoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loxapine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lurasidone.Approved
Magnesium HydroxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium hydroxide.Approved
Magnesium oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium salicylate.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meclizine.Approved
MefloquineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meprobamate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methohexital.Approved
MethotrimeprazinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with ECGONINE METHYL ESTER.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methylphenobarbital.Approved
MetyrosinePregabalin may increase the sedative activities of Metyrosine.Approved
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Pregabalin.Experimental
MianserinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mianserin.Approved
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Pregabalin.Approved, Investigational
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Pregabalin.Approved, Investigational, Vet Approved
MidazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Midazolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Milnacipran.Approved
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Pregabalin.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Investigational
MirtazapinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumPregabalin may increase the neuromuscular blocking activities of Mivacurium.Approved
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Pregabalin.Approved
MolindoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Morphine.Approved, Investigational
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Pregabalin.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Investigational
NafcillinThe metabolism of Pregabalin can be increased when combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Pregabalin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nalbuphine.Approved
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Pregabalin.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrazepam.Approved
NitroprussidePregabalin may increase the hypotensive activities of Nitroprusside.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrous oxide.Approved, Vet Approved
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Pregabalin.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with 1,1,1,2 Tetrafluoroethane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nortriptyline.Approved
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Pregabalin.Approved, Vet Approved
OlanzapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olanzapine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olopatadine.Approved
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Pregabalin.Investigational
OndansetronThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of Pregabalin can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Pregabalin is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxazepam.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxetacaine.Investigational
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Pregabalin.Approved
OxprenololThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxymorphone.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paliperidone.Approved
ParaldehydePregabalin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paroxetine.Approved, Investigational
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Pregabalin.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
PerazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perazine.Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Pregabalin.Approved
PerospironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perphenazine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pethidine.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenobarbital.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Pregabalin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pimozide.Approved
PioglitazonePregabalin may increase the fluid retaining activities of Pioglitazone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Piritramide.Investigational
PomalidomideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pomalidomide.Approved
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Pregabalin.Approved, Investigational, Vet Approved
PramipexolePregabalin may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prazepam.Approved, Illicit
PrazosinPrazosin may increase the hypotensive activities of Pregabalin.Approved
PrilocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prilocaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prochlorperazine.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propofol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Protriptyline.Approved
QuazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quetiapine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Pregabalin.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Raclopride.Investigational
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Pregabalin.Experimental
RamelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ramelteon.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Pregabalin.Approved
RapacuroniumPregabalin may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RemifentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remoxipride.Approved, Withdrawn
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Pregabalin.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Pregabalin.Approved
RifabutinThe serum concentration of Pregabalin can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Pregabalin can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Pregabalin can be decreased when it is combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ritanserin.Investigational
RopinirolePregabalin may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ropivacaine.Approved
RosiglitazonePregabalin may increase the fluid retaining activities of Rosiglitazone.Approved, Investigational
RotigotinePregabalin may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Pregabalin.Approved
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Pregabalin.Experimental
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Pregabalin.Approved, Vet Approved
ScopolamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Secobarbital.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Uc1010.Investigational
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Pregabalin.Approved
SertindoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sevoflurane.Approved, Vet Approved
SilodosinSilodosin may increase the hypotensive activities of Pregabalin.Approved
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Pregabalin.Experimental
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Pregabalin.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
SolithromycinThe metabolism of Pregabalin can be decreased when combined with Solithromycin.Investigational
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Pregabalin.Approved
StiripentolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sufentanil.Approved, Investigational
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Pregabalin.Approved
SulpirideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sulpiride.Approved
SuvorexantPregabalin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TamsulosinTamsulosin may increase the hypotensive activities of Pregabalin.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tasimelteon.Approved
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Pregabalin.Approved
TelithromycinThe metabolism of Pregabalin can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Temazepam.Approved
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Pregabalin.Experimental, Investigational
TerazosinTerazosin may increase the hypotensive activities of Pregabalin.Approved
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Pregabalin.Approved, Investigational, Vet Approved
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Pregabalin.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrodotoxin.Investigational
ThalidomidePregabalin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thioridazine.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiothixene.Approved
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Pregabalin.Approved
TiagabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiapride.Approved, Investigational
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Pregabalin.Approved
TizanidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tolcapone.Approved, Withdrawn
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Pregabalin.Approved, Vet Approved
TopiramateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Pregabalin.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Pregabalin.Approved
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trifluoperazine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triflupromazine.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Pregabalin.Experimental
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Pregabalin.Approved, Investigational
TrimipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triprolidine.Approved
TroglitazonePregabalin may increase the fluid retaining activities of Troglitazone.Withdrawn
Valproic AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Valproic Acid.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vigabatrin.Approved
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Pregabalin.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vortioxetine.Approved
YohimbineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziprasidone.Approved
ZolpidemPregabalin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol (may increase CNS effects).
  • When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
References
Synthesis Reference

Mark Burk, "Asymmetric synthesis of pregabalin." U.S. Patent US20030212290, issued November 13, 2003.

US20030212290
General References
  1. Authors unspecified: Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Fed Regist. 2005 Jul 28;70(144):43633-5. [PubMed:16050051 ]
  2. Su TZ, Feng MR, Weber ML: Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells. J Pharmacol Exp Ther. 2005 Jun;313(3):1406-15. Epub 2005 Mar 15. [PubMed:15769862 ]
  3. Li Z, Taylor CP, Weber M, Piechan J, Prior F, Bian F, Cui M, Hoffman D, Donevan S: Pregabalin is a potent and selective ligand for alpha(2)delta-1 and alpha(2)delta-2 calcium channel subunits. Eur J Pharmacol. 2011 Sep 30;667(1-3):80-90. doi: 10.1016/j.ejphar.2011.05.054. Epub 2011 Jun 1. [PubMed:21651903 ]
External Links
ATC CodesN03AX16 — Pregabalin
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.46 MB)
MSDSDownload (106 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentNicotine Dependence1
0CompletedTreatmentPost-Operative Pain1
0RecruitingTreatmentCannabis-use Disorders1
1CompletedNot AvailableHealthy Volunteers10
1CompletedNot AvailableNerve Pain1
1CompletedBasic ScienceHealthy Volunteers8
1CompletedScreeningHealthy Volunteers1
1CompletedTreatmentDiabetic Neuropathies / Idiopathic Distal Sensory Polyneuropathy / Painful Small-Fiber Neuropathy / Postherpetic Neuralgia1
1CompletedTreatmentHealthy Volunteers2
1CompletedTreatmentPain, Acute1
1CompletedTreatmentPeripheral Neuropathy Pain1
1CompletedTreatmentPeripheral Nueropathy Pain1
1Unknown StatusTreatmentRefractive Errors1
1, 2CompletedTreatmentEpilepsy, Localization Related1
1, 2CompletedTreatmentPrimary Total Knee Arthroplasty1
1, 2RecruitingTreatmentCoughing1
2CompletedNot AvailableFeeling Anxious1
2CompletedSupportive CareBrain and Central Nervous System Tumors / Seizures1
2CompletedTreatmentAlcohol Dependence1
2CompletedTreatmentCRP1
2CompletedTreatmentCancers / Pain1
2CompletedTreatmentDental Anxiety1
2CompletedTreatmentDiabetes Mellitus (DM) / Diabetic Neuropathies / Pain, Chronic1
2CompletedTreatmentDiabetic Neuropathic Pain1
2CompletedTreatmentDiabetic Neuropathies1
2CompletedTreatmentDiabetic Neuropathy, Painful2
2CompletedTreatmentDiabetic Neuropathy, Painful; Diabetic Neuropathies1
2CompletedTreatmentDiabetic Peripheral Neuropathic Pain2
2CompletedTreatmentDiabetic Peripheral Neuropathy (DPN)1
2CompletedTreatmentDiabetic Peripheral Neuropathy (DPN) / Pain1
2CompletedTreatmentElective Laparoscopic Cholecystectomy / Sevoflurane Anesthesia1
2CompletedTreatmentEpilepsy, Localization Related1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentOver Active Bladder1
2CompletedTreatmentPain1
2CompletedTreatmentPain / Postherpetic Neuralgia1
2CompletedTreatmentPostherpetic Neuralgia1
2CompletedTreatmentRestless Legs Syndrome (RLS)1
2RecruitingTreatmentEarache1
2RecruitingTreatmentGulf War Illness1
2RecruitingTreatmentIdiopathic Small Fiber Neuropathy1
2TerminatedTreatmentFibromyalgia1
2TerminatedTreatmentHerpes Zoster / Postherpetic Neuralgia1
2TerminatedTreatmentOrofacial Pain / Pain, Neuropathic1
2TerminatedTreatmentPain, Chronic1
2TerminatedTreatmentPainful Diabetic Peripheral Neuropathy (PDPN)1
2TerminatedTreatmentPostherpetic Neuralgia1
2TerminatedTreatmentVulvar Vestibulitis / Vulvodynia1
2TerminatedTreatmentNeurocostal neuralgia1
2Unknown StatusTreatmentCancer, Breast / Drug-Related Side Effects and Adverse Reactions / Pain / Taxane1
2Unknown StatusTreatmentFibromyalgia / Pain, Chronic1
2WithdrawnTreatmentDiabetes / Pain, Neuropathic1
2, 3Active Not RecruitingBasic ScienceFibromyalgia1
2, 3CompletedPreventionPostoperative pain1
2, 3CompletedTreatmentAcute Agitation / Dementias / Pain1
2, 3CompletedTreatmentDiabetes Mellitus (DM) / Peripheral Neuropathy1
2, 3CompletedTreatmentPancreatitis, Chronic1
2, 3RecruitingPreventionEye Dryness1
3Active Not RecruitingPreventionChronic Post-surgical Pain / Post-mastectomy Pain Syndrome1
3Active Not RecruitingTreatmentPostoperative pain1
3CompletedPreventionDelirium / Pain1
3CompletedPreventionPain / Pain, Neuropathic / Polyneuropathies1
3CompletedPreventionPost-Operative Pain1
3CompletedSupportive CareCancer, Breast / Menopausal Hot Flushes1
3CompletedSupportive CareIntervertebral Disc Herniation1
3CompletedTreatmentBreast Cancer Surgery / Post Operative Pain1
3CompletedTreatmentDiabetic Neuropathies1
3CompletedTreatmentDiabetic Neuropathies / Neurocostal neuralgia1
3CompletedTreatmentDiabetic Neuropathy, Painful7
3CompletedTreatmentDiabetic Peripheral Neuropathy (DPN)1
3CompletedTreatmentDiabetic Peripheral Neuropathy (DPN) / Nerve Pain1
3CompletedTreatmentDisseminated Sclerosis / Pain, Neuropathic1
3CompletedTreatmentEpilepsies1
3CompletedTreatmentEpilepsy, Complex Partial / Epilepsy, Localization Related1
3CompletedTreatmentEpilepsy, Localization Related2
3CompletedTreatmentEpilepsy, Localization Related / Sleep Deprivation1
3CompletedTreatmentEpilepsy, Localization Related / Partial onset seizure Epilepsy1
3CompletedTreatmentFeeling Anxious1
3CompletedTreatmentFibromyalgia13
3CompletedTreatmentFibromyalgia / Sleep disorders and disturbances1
3CompletedTreatmentGeneralized Anxiety Disorder (GAD)2
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Peripheral Neuropathy2
3CompletedTreatmentIdiopathic Restless Legs Syndrome1
3CompletedTreatmentInguinal Hernias / Postoperative pain1
3CompletedTreatmentNeuroses, Anxiety1
3CompletedTreatmentPain2
3CompletedTreatmentPain Associated With Fibromyalgia3
3CompletedTreatmentPain, Chronic1
3CompletedTreatmentPain, Neuropathic4
3CompletedTreatmentPainful Diabetic Peripheral Neuropathy (PDPN)1
3CompletedTreatmentNeurocostal neuralgia / Pain / Spinal Cord Diseases / Spinal Cord Injuries (SCI)1
3CompletedTreatmentPost Herpetic Neuralgia1
3CompletedTreatmentPostherpetic Neuralgia2
3CompletedTreatmentPostoperative pain2
3CompletedTreatmentPostoperative pain / Synovitis of osteoarthritis1
3CompletedTreatmentRadicular syndrome1
3CompletedTreatmentRestless Legs Syndrome (RLS)1
3CompletedTreatmentSeizure Disorder, Partial4
3CompletedTreatmentSeizures1
3CompletedTreatmentNeurocostal neuralgia / Spinal Cord Injuries (SCI)1
3CompletedTreatmentNeurocostal neuralgia2
3CompletedTreatmentPartial onset seizure Epilepsy2
3CompletedTreatmentSynovitis of osteoarthritis1
3Not Yet RecruitingPreventionHerpetic Neuralgia1
3Not Yet RecruitingPreventionPersistent Postoperative Pain1
3Not Yet RecruitingTreatmentAlcohol Use Disorder (AUD) / PTSD1
3RecruitingPreventionPhantom Pain1
3RecruitingPreventionPostoperative pain1
3RecruitingTreatmentAnxiety Disorder / Dementias / Depressive State / Psychosomatic Disorders / Schizophrenic Disorders1
3RecruitingTreatmentEpilepsy, Partial Seizures / Epilepsy, Primary Generalized Tonic-Clonic Seizures1
3RecruitingTreatmentFibromyalgia1
3RecruitingTreatmentLiver Cirrhosis / Muscle Cramps1
3RecruitingTreatmentPain of Mononeuropathy1
3RecruitingTreatmentPain, Neuropathic1
3RecruitingTreatmentPeripheral Neuropathic Pain1
3RecruitingTreatmentPostherpetic Neuralgia1
3TerminatedPreventionPain / Spinal Cord Trauma1
3TerminatedSupportive CarePerioperative Pain1
3TerminatedTreatmentEpilepsies1
3TerminatedTreatmentEpilepsy, Localization Related1
3TerminatedTreatmentFusion of Spine (Disease)1
3TerminatedTreatmentHIV-1 Infections / Pain, Neuropathic1
3TerminatedTreatmentNeuropathy1
3Unknown StatusPreventionInguinal Hernias / Postoperative pain1
3Unknown StatusTreatmentCancers / Neurocostal neuralgia1
3Unknown StatusTreatmentChronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)1
3Unknown StatusTreatmentDiabetic Neuropathies1
3Unknown StatusTreatmentPostoperative pain1
3WithdrawnPreventionPain, Chronic1
3WithdrawnTreatmentMigraine Disorders1
3WithdrawnTreatmentRestless Legs Syndrome (RLS)1
4Active Not RecruitingTreatmentAlcoholism1
4Active Not RecruitingTreatmentPain, Acute1
4Active Not RecruitingTreatmentPost Operative Pain1
4CompletedNot AvailableHealthy Lactating Women1
4CompletedNot AvailableHealthy Volunteers2
4CompletedNot AvailableIrritable Bowel Syndrome (IBS)1
4CompletedNot AvailablePain, Neuropathic2
4CompletedNot AvailablePostoperative pain1
4CompletedDiagnosticAnxiety Disorder1
4CompletedOtherHealthy Volunteers1
4CompletedTreatmentAnxiety-comorbidity to Schizophrenia / Schizophrenic Disorders1
4CompletedTreatmentCentral Neuropathic Pain1
4CompletedTreatmentCervical Spondylosis / Cervical Spondylotic Myelopathy / Cervical Spondylotic Radiculopathy1
4CompletedTreatmentChemotherapy Induced Neuropathic Pain / Diabetic Peripheral Neuropathic Pain (DPN) / HIV-related Neuropathic Pain (HIV) / Postherpetic Neuralgia ( PHN )1
4CompletedTreatmentComplex Partial Seizure Disorder / Epilepsies / Epilepsy, Localization Related / Partial Seizure Disorder1
4CompletedTreatmentDiabetic Neuropathies1
4CompletedTreatmentDiabetic Neuropathy, Painful3
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain2
4CompletedTreatmentDiabetic Peripheral Neuropathy (DPN)1
4CompletedTreatmentDisk Prolapse / Intervertebral Disk Displacement1
4CompletedTreatmentEpilepsies1
4CompletedTreatmentEpilepsy, Complex Partial1
4CompletedTreatmentEpilepsy, Localization Related1
4CompletedTreatmentFailed Back Surgery Syndrome / Intervertebral Disc Herniation / Neuropathy; Radicular, Lumbar, Lumbosacral / Spinal Stenosis1
4CompletedTreatmentFibromyalgia4
4CompletedTreatmentGeneralized Anxiety Disorder (GAD)1
4CompletedTreatmentLiving Donors1
4CompletedTreatmentLumbar Spinal Fusions1
4CompletedTreatmentNeurogenic Intermittent Claudication / Spinal Stenosis of Lumbar Region1
4CompletedTreatmentNeurologic Claudication in Patients With Lumbar Spinal Stenosis1
4CompletedTreatmentNon-diabetic Painful Peripheral Polyneuropathy / Peripheral Nerve Injury (PNI) / Postherpetic Neuralgia ( PHN )1
4CompletedTreatmentOpioids Use / Postoperative pain1
4CompletedTreatmentPain1
4CompletedTreatmentPain, Chronic1
4CompletedTreatmentPainful Diabetic Neuropathy and Post Herpetic Neuralgia1
4CompletedTreatmentPain / Postoperative1
4CompletedTreatmentPost-Herpetic Neuralgia (PHN)1
4CompletedTreatmentPost-Operative Pain1
4CompletedTreatmentPost-thoracotomy Pain1
4CompletedTreatmentPostherpetic Neuralgia ( PHN )1
4CompletedTreatmentPostoperative Pain Management1
4CompletedTreatmentPostoperative Pain Management / Total Knee Arthroplasty (TKA)1
4CompletedTreatmentPostoperative pain3
4CompletedTreatmentSeizures1
4CompletedTreatmentNeurocostal neuralgia / Spinal Cord Injuries (SCI)1
4CompletedTreatmentAdjunct to general anesthesia therapy / Surgery, Laparoscopic1
4CompletedTreatmentTremor, Essential2
4CompletedTreatmentNeurocostal neuralgia1
4RecruitingSupportive CareScoliosis / Spondylolisthesis1
4RecruitingTreatmentArterial Occlusive Diseases / Critical Limb Ischemia (CLI) / Pain / Transient ischemia attacks1
4RecruitingTreatmentCryptogenic Sensory Polyneuropathy1
4RecruitingTreatmentEpilepsy, Localization Related1
4RecruitingTreatmentHepatocellular Cancer1
4RecruitingTreatmentLumbar Disc Disease / Lumbar Radiculopathy / Prolapsed Lumbar Disc1
4RecruitingTreatmentMalignant Neoplasm of Pancreas / Visceral Pain1
4RecruitingTreatmentObsessive-Compulsive Disorder (OCD)1
4RecruitingTreatmentOpiate withdrawal symptoms1
4TerminatedBasic ScienceSubstance-Related Disorders1
4TerminatedTreatmentAbdominal Pain (AP) / Surgical Adhesions1
4TerminatedTreatmentBone Neoplasms / Cancers / Pain, Intractable1
4TerminatedTreatmentChemotherapy-induced Peripheral Neuropathy (CIPN)1
4TerminatedTreatmentChronic Low Back Pain With a Neuropathic Component1
4TerminatedTreatmentEpilepsies / Feeling Anxious1
4TerminatedTreatmentPostherpetic Neuralgia1
4TerminatedTreatmentPostoperative pain1
4TerminatedTreatmentUterine Artery Embolization / Uterine Leiomyomas1
4TerminatedTreatmentPartial onset seizure Epilepsy1
4Unknown StatusBasic ScienceDiabetes Mellitus (DM) / Painful Distal Symmetric Sensorimotor Polyneuropathy1
4Unknown StatusPreventionChronic Illnesses / Hyperalgesia / Pain / Pain, Neuropathic1
4Unknown StatusTreatmentFeeling Anxious1
4Unknown StatusTreatmentPain, Neuropathic / Spinal Cord Injuries (SCI)1
4Unknown StatusTreatmentPain, Neuropathic / Tactile Hyperalgesia1
4Unknown StatusTreatmentPolyneuropathies1
4Unknown StatusTreatmentUremic Pruritus2
4WithdrawnDiagnosticLow Back Pain (LBP) / Neurocostal neuralgia1
4WithdrawnTreatmentChronic Pain, Postoperative / Headaches1
4WithdrawnTreatmentDiabetic Polyneuropathy / Postherpetic Neuralgia1
4WithdrawnTreatmentFibromyalgia1
4WithdrawnTreatmentRestless Legs Syndrome (RLS)1
Not AvailableActive Not RecruitingNot AvailablePain Associated With Fibromyalgia1
Not AvailableActive Not RecruitingNot AvailablePain, Neuropathic1
Not AvailableActive Not RecruitingNot AvailableNeurocostal neuralgia1
Not AvailableActive Not RecruitingPreventionPain, Cancer / Pain, Neuropathic / Persistent Post-surgical Pain1
Not AvailableActive Not RecruitingSupportive CarePain / Peripheral Neuropathy1
Not AvailableCompletedNot AvailableBlock1
Not AvailableCompletedNot AvailableEpilepsies1
Not AvailableCompletedNot AvailableEpilepsies / Fibromyalgia / Pain, Neuropathic / Post-market Surveillance1
Not AvailableCompletedNot AvailableEpilepsies / Neurocostal neuralgia1
Not AvailableCompletedNot AvailablePain, Neuropathic1
Not AvailableCompletedPreventionPain1
Not AvailableCompletedPreventionPain, Neuropathic1
Not AvailableCompletedSupportive CarePain1
Not AvailableCompletedSupportive CarePain / Peripheral Neuropathy1
Not AvailableCompletedSupportive CarePostoperative pain1
Not AvailableCompletedTreatmentHepatocellular,Carcinoma / Postoperative pain1
Not AvailableCompletedTreatmentPain1
Not AvailableCompletedTreatmentPostoperative pain1
Not AvailableNot Yet RecruitingPreventionAnterior Cruciate Ligament (ACL) Reconstruction1
Not AvailableNot Yet RecruitingTreatmentChronic Pain, Postoperative1
Not AvailableNot Yet RecruitingTreatmentPeripheral Arterial Disease (PAD)1
Not AvailableRecruitingNot AvailablePain, Neuropathic / Postoperative pain1
Not AvailableRecruitingOtherNeuropathy / Pain1
Not AvailableRecruitingSupportive CarePostoperative pain1
Not AvailableRecruitingTreatmentOropharyngeal Cancers / Squamous Cell Carcinoma to the Head and Neck1
Not AvailableSuspendedTreatmentSmall-Fiber Neuropathy1
Not AvailableTerminatedNot AvailableSpinal Cord Injuries (SCI)1
Not AvailableTerminatedTreatmentCocaine Abuse / Cocaine-Related Disorders1
Not AvailableTerminatedTreatmentComplex Regional Pain Syndromes (CRPS)1
Not AvailableTerminatedTreatmentPostoperative pain1
Not AvailableUnknown StatusPreventionPain1
Not AvailableUnknown StatusSupportive CareNasal Septum Deviation1
Not AvailableUnknown StatusSupportive CarePain1
Not AvailableUnknown StatusSupportive CarePostoperative pain1
Not AvailableUnknown StatusTreatmentFibromyalgia1
Not AvailableUnknown StatusTreatmentMultimodal Analgesia / Postoperative Pain Control1
Not AvailableUnknown StatusTreatmentPain1
Not AvailableUnknown StatusTreatmentTo Assess the Beneficial Preemptive and Preventive Effects of PGL on the Immediate and Late (1- and 3 Months) Postoperative Analgesia Requirements1
Not AvailableWithdrawnPreventionPain1
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
CapsuleOral100 mg/1
CapsuleOral100 mg
CapsuleOral150 mg
CapsuleOral150 mg/1
CapsuleOral200 mg
CapsuleOral200 mg/1
CapsuleOral225 mg/1
CapsuleOral225 mg
CapsuleOral25 mg/1
CapsuleOral25 mg
CapsuleOral300 mg
CapsuleOral300 mg/1
CapsuleOral50 mg/1
CapsuleOral50 mg
CapsuleOral75 mg
CapsuleOral75 mg/1
SolutionOral20 mg/mL
Prices
Unit descriptionCostUnit
Lyrica 100 mg capsule2.88USD capsule
Lyrica 150 mg capsule2.88USD capsule
Lyrica 50 mg capsule2.88USD capsule
Lyrica 75 mg capsule2.88USD capsule
Lyrica 200 mg capsule2.75USD capsule
Lyrica 225 mg capsule2.75USD capsule
Lyrica 25 mg capsule2.75USD capsule
Lyrica 300 mg capsule2.75USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2297163 No2001-11-202018-08-18Canada
CA2327285 No2005-06-142019-05-10Canada
US5563175 No1993-10-082013-10-08Us
US6001876 No1998-12-302018-12-30Us
US6197819 No1998-12-302018-12-30Us
USRE41920 No1998-12-302018-12-30Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityFreely soluble FDA label
logP-1.35FDA label
pKa4.2 and 10.6 FDA label
Predicted Properties
PropertyValueSource
Water Solubility11.3 mg/mLALOGPS
logP-1.4ALOGPS
logP-1.3ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)4.8ChemAxon
pKa (Strongest Basic)10.23ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity43.68 m3·mol-1ChemAxon
Polarizability18.08 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9727
Blood Brain Barrier+0.9382
Caco-2 permeable-0.6531
P-glycoprotein substrateNon-substrate0.683
P-glycoprotein inhibitor INon-inhibitor0.965
P-glycoprotein inhibitor IINon-inhibitor0.9424
Renal organic cation transporterNon-inhibitor0.9245
CYP450 2C9 substrateNon-substrate0.8758
CYP450 2D6 substrateNon-substrate0.7926
CYP450 3A4 substrateNon-substrate0.6914
CYP450 1A2 substrateNon-inhibitor0.9385
CYP450 2C9 inhibitorNon-inhibitor0.9425
CYP450 2D6 inhibitorNon-inhibitor0.9539
CYP450 2C19 inhibitorNon-inhibitor0.9629
CYP450 3A4 inhibitorNon-inhibitor0.9352
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9784
Ames testNon AMES toxic0.938
CarcinogenicityNon-carcinogens0.5678
BiodegradationReady biodegradable0.8201
Rat acute toxicity1.7046 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9868
hERG inhibition (predictor II)Non-inhibitor0.8909
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0a4i-0900000000-555454e7e8e11dab591dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0a4i-0900000000-1a52554257d7f4b1c62eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0a4i-0900000000-d48cd6eeef012787cc04View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0a4i-0900000000-4b11df5208caa2e97dd2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0a4i-0900000000-605dc241ffd3a07a9220View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-01ox-0900000000-fb081cde39dde2ce89f8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0006-0900000000-3d95bb5278c7866658a0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0006-0900000000-96cebf4a3610cbf02059View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0006-8900000000-385584fca9e88b90a95bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0006-9800000000-a1c6718b087b06101b8dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0a4i-9200000000-5f291c943a1d1ae214adView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0a4i-9100000000-5283d02d98611a8c2c38View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0a4i-9000000000-8797f8d2776fcdb4b6d5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0a4i-9000000000-a9ddfcf2032ffc9f53adView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGamma amino acids and derivatives
Alternative ParentsMedium-chain fatty acids / Branched fatty acids / Amino fatty acids / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives
SubstituentsGamma amino acid or derivatives / Medium-chain fatty acid / Amino fatty acid / Branched fatty acid / Fatty acyl / Fatty acid / Amino acid / Carboxylic acid / Monocarboxylic acid or derivatives / Amine
Molecular FrameworkAliphatic acyclic compounds
External Descriptorsgamma-amino acid (CHEBI:64356 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to...
Gene Name:
CACNA1A
Uniprot ID:
O00555
Uniprot Name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Molecular Weight:
282362.39 Da
References
  1. Gazulla J, Tintore M: The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6. Acta Neurol Scand. 2007 May;115(5):356-63. [PubMed:17489948 ]
  2. Gazulla J, Tintore MA: The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit. Med Hypotheses. 2007;68(1):131-6. Epub 2006 Aug 8. [PubMed:16899342 ]
  3. Jacquy J, Lossignol D, Sternon J: [Pregabalin (Lyrica) and neuropathic pain syndromes]. Rev Med Brux. 2006 Sep-Oct;27(5):445-50. [PubMed:17144644 ]
  4. Taylor CP, Angelotti T, Fauman E: Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007 Feb;73(2):137-50. Epub 2006 Nov 28. [PubMed:17126531 ]
  5. Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su TZ, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T, Williams D: Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17537-42. Epub 2006 Nov 6. [PubMed:17088553 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
Other
General Function:
Sodium:dicarboxylate symporter activity
Specific Function:
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Gene Name:
SLC1A1
Uniprot ID:
P43005
Uniprot Name:
Excitatory amino acid transporter 3
Molecular Weight:
57099.835 Da
References
  1. Ryu JH, Lee PB, Kim JH, Do SH, Kim CS: Effects of pregabalin on the activity of glutamate transporter type 3. Br J Anaesth. 2012 Aug;109(2):234-9. doi: 10.1093/bja/aes120. Epub 2012 Apr 16. [PubMed:22511482 ]
Drug created on June 13, 2005 07:24 / Updated on July 27, 2017 15:59