Antituberculosis Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
DrugDrug NameDrug Description
DB00233Aminosalicylic acidAn aminosalicylate drug used to induce remission in ulcerative colitis.
DB00260CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
DB00314CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
DB00609EthionamideA second line antitubercular agent used to treat tuberculosis when other treatments have failed.
DB00701AmprenavirA protease inhibitor used to treat HIV infection.
DB01201RifapentineAn antibiotic agent used in the treatment of pulmonary tuberculosis.
DB01208SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus...
DB04934RifalazilInvestigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease.
DB05154PretomanidPart of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis.
DB06827ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
DB08903BedaquilineA diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB).
DB08993EnviomycinCyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
DB09499Thiosulfuric acidA sulfur donor used for sequential use with sodium nitrite for the reversal of acute cyanide poisoning that is judged to be life-threatening.
DB11774PazufloxacinPazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).
DB12667ProtionamideProthionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.
DB12829AmithiozoneAmithiozone has been used in trials studying the treatment of Mycobacterium Avium-intracellulare Infection.
DB00330EthambutolAn antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
DB00339PyrazinamideAn antituberculosis agent used as a component of tuberculosis (TB) treatment.
DB00615RifabutinAn antibiotic used to treat mycobacterium avium complex disease in patients with HIV.
DB00951IsoniazidAn antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
DB01045RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
DB00688Mycophenolate mofetilAn inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
DB01024Mycophenolic acidAn immunosuppressant used to prevent organ transplant rejections.
DrugDrug NameTargetType
DB00233Aminosalicylic acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic acidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic acidProstaglandin G/H synthase 2target
DB00233Aminosalicylic acidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic acidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00233Aminosalicylic acidMyeloperoxidaseenzyme
DB00260CycloserineD-alanine--D-alanine ligase Atarget
DB00260CycloserineAlanine racemasetarget
DB00260CycloserineAromatic-L-amino-acid decarboxylaseenzyme
DB00260CycloserineProton-coupled amino acid transporter 2transporter
DB00314Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB00609EthionamideCatalase-peroxidasetarget
DB00609EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB00701AmprenavirHuman immunodeficiency virus type 1 proteasetarget
DB00701AmprenavirCytochrome P450 3A4enzyme
DB00701AmprenavirP-glycoprotein 1transporter
DB00701AmprenavirMultidrug resistance-associated protein 1transporter
DB00701AmprenavirCytochrome P450 2B6enzyme
DB00701AmprenavirCytochrome P450 2C19enzyme
DB00701AmprenavirCytochrome P450 2C9enzyme
DB00701AmprenavirCytochrome P450 2D6enzyme
DB00701AmprenavirCytochrome P450 3A5enzyme
DB00701AmprenavirSolute carrier organic anion transporter family member 1B1transporter
DB01201RifapentineDNA-directed RNA polymerase subunit beta'target
DB01201RifapentineCytochrome P450 2C8enzyme
DB01201RifapentineCytochrome P450 2C9enzyme
DB01201RifapentineCytochrome P450 3A4enzyme
DB01201RifapentineCytochrome P450 2C19enzyme
DB01201RifapentineCytochrome P450 2B6enzyme
DB01201RifapentineCytochrome P450 3A Subfamilyenzyme
DB01208SparfloxacinDNA gyrase subunit Atarget
DB01208SparfloxacinDNA topoisomerase 4 subunit Atarget
DB01208SparfloxacinDNA topoisomerase 2-alphatarget
DB01208SparfloxacinSolute carrier family 22 member 5transporter
DB01208SparfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinP-glycoprotein 1transporter
DB01208SparfloxacinCytochrome P450 1A2enzyme
DB04934RifalazilDNA-directed RNA polymerase subunit betatarget
DB04934RifalazilCytochrome P450 3A4enzyme
DB05154PretomanidDeazaflavin-dependent nitroreductaseenzyme
DB05154PretomanidSolute carrier family 22 member 8transporter
DB05154PretomanidCytochrome P450 3A4enzyme
DB05154PretomanidFatty acid synthetasetarget
DB05154PretomanidUncharacterized MFS-type transporter EfpAtarget
DB05154PretomanidNucleoid-associated protein Lsr2target
DB05154PretomanidCyd operon, Mycobacterium tuberculosistarget
DB05154PretomanidEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB06827Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB08903BedaquilineCytochrome P450 3A4enzyme
DB08903BedaquilineATP synthase subunit ctarget
DB09499Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
DB11774PazufloxacinCytochrome P450 1A2enzyme
DB00330EthambutolProbable arabinosyltransferase Btarget
DB00330EthambutolProbable arabinosyltransferase Atarget
DB00330EthambutolProbable arabinosyltransferase Ctarget
DB00339PyrazinamideXanthine dehydrogenase/oxidaseenzyme
DB00339PyrazinamideFatty acid synthetasetarget
DB00339PyrazinamideAldehyde oxidaseenzyme
DB00615RifabutinDNA-directed RNA polymerase subunit alphatarget
DB00615RifabutinHeat shock protein HSP 90-alphatarget
DB00615RifabutinEndoplasmintarget
DB00615RifabutinCytochrome P450 3A4enzyme
DB00615RifabutinDNA-directed RNA polymerase subunit betatarget
DB00615RifabutinDNA-directed RNA polymerase subunit beta'target
DB00615RifabutinCytochrome P450 2C19enzyme
DB00615RifabutinCytochrome P450 2B6enzyme
DB00615RifabutinCytochrome P450 2C8enzyme
DB00615RifabutinCytochrome P450 2C9enzyme
DB00615RifabutinP-glycoprotein 1transporter
DB00951IsoniazidCatalase-peroxidasetarget
DB00951IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB00951IsoniazidCytochrome P450 2E1enzyme
DB00951IsoniazidCytochrome P450 1A2enzyme
DB00951IsoniazidCytochrome P450 2C9enzyme
DB00951IsoniazidCytochrome P450 2D6enzyme
DB00951IsoniazidCytochrome P450 2C19enzyme
DB00951IsoniazidArylamine N-acetyltransferase 2enzyme
DB00951IsoniazidArylamine N-acetyltransferaseenzyme
DB00951IsoniazidCytochrome P450 2A6enzyme
DB00951IsoniazidCytochrome P450 2C8enzyme
DB00951IsoniazidCytochrome P450 2C8target
DB00951IsoniazidCytochrome P450 1A2target
DB00951IsoniazidCytochrome P450 3A4target
DB00951IsoniazidCytochrome P450 2C19target
DB00951IsoniazidDihydrofolate reductasetarget
DB00951IsoniazidSerum albumincarrier
DB01045RifampicinDNA-directed RNA polymerase subunit betatarget
DB01045RifampicinNuclear receptor subfamily 1 group I member 2target
DB01045RifampicinCytochrome P450 3A4enzyme
DB01045RifampicinCytochrome P450 1A2enzyme
DB01045RifampicinCytochrome P450 2C8enzyme
DB01045RifampicinUDP-glucuronosyltransferase 1-1enzyme
DB01045RifampicinCytochrome P450 2C9enzyme
DB01045RifampicinCytochrome P450 2B6enzyme
DB01045RifampicinCytochrome P450 2C19enzyme
DB01045RifampicinCanalicular multispecific organic anion transporter 2transporter
DB01045RifampicinMultidrug resistance-associated protein 5transporter
DB01045RifampicinP-glycoprotein 1transporter
DB01045RifampicinCanalicular multispecific organic anion transporter 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 2B1transporter
DB01045RifampicinBile salt export pumptransporter
DB01045RifampicinMultidrug resistance-associated protein 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1A2transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinSolute carrier family 22 member 7transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B1transporter
DB01045RifampicinCytochrome P450 2A6enzyme
DB01045RifampicinCytochrome P450 2E1enzyme
DB01045RifampicinCytochrome P450 3A43enzyme
DB01045RifampicinCytochrome P450 3A7enzyme
DB01045RifampicinSolute carrier family 22 member 6transporter
DB01045RifampicinSolute carrier family 22 member 8transporter
DB01045RifampicinUDP-glucuronosyltransferase 1-9enzyme
DB01045RifampicinCytochrome P450 3A5enzyme
DB01045RifampicinSerum albumincarrier
DB01045Rifampicinalpha1-acid glycoproteincarrier
DB00688Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 2target
DB00688Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 1target
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-1enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-7enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-6enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-9enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 2B7enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-8enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-10enzyme
DB00688Mycophenolate mofetilLiver carboxylesterase 1enzyme
DB00688Mycophenolate mofetilCytochrome P450 3A4enzyme
DB00688Mycophenolate mofetilCytochrome P450 3A5enzyme
DB00688Mycophenolate mofetilCytochrome P450 2C8enzyme
DB00688Mycophenolate mofetilSolute carrier organic anion transporter family member 1B1transporter
DB00688Mycophenolate mofetilSolute carrier organic anion transporter family member 1B3transporter
DB00688Mycophenolate mofetilATP-binding cassette sub-family G member 2transporter
DB00688Mycophenolate mofetilP-glycoprotein 1transporter
DB00688Mycophenolate mofetil6-pyruvoyl tetrahydrobiopterin synthasetarget
DB00688Mycophenolate mofetilCarboxylic ester hydrolaseenzyme
DB00688Mycophenolate mofetilCanalicular multispecific organic anion transporter 1transporter
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 2target
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 1target
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-1enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-9enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 2B7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-6enzyme