Antituberculosis Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
DrugDrug NameDrug Indication
DB00233Aminosalicylic AcidFor the treatment of tuberculosis
DB00260CycloserineUsed in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
DB00314CapreomycinUsed in the treatment of tuberculosis in combination with other drugs.
DB00609EthionamideFor use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
DB00701AmprenavirFor the treatment of HIV-1 infection in combination with other antiretroviral agents.
DB01201RifapentineFor the treatment of pulmonary tuberculosis.
DB01208SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus pneumoniae) and acute bacterial exacerbations of chronic bronchitis (caused by Chlamydia pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus pneumoniae).
DB04934RifalazilInvestigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease.
DB05154PretomanidInvestigated for use/treatment in bacterial infection and tuberculosis.
DB06827ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
DB08903BedaquilineBedaquiline is indicated as part of combination therapy in adults (≥ 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB).
DB08993EnviomycinNot Available
DB09499Thiosulfuric acidAntidote: Sodium thiosulfate is indicated to counteract or neutralize actions of poisons, e.g. cyanide poisoning. Antineoplastic adjunct:
DB11774PazufloxacinNot Available
DB12667ProtionamideNot Available
DB12829AmithiozoneNot Available
DB00330EthambutolFor use, as an adjunct, in the treatment of pulmonary tuberculosis.
DB00339PyrazinamideFor the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
DB00615RifabutinFor the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
DB00951IsoniazidFor the treatment of all forms of tuberculosis in which organisms are susceptible.
DB01045RifampicinFor the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
DrugDrug NameTargetType
DB00233Aminosalicylic AcidMyeloperoxidaseenzyme
DB00233Aminosalicylic Acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic AcidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic AcidProstaglandin G/H synthase 2target
DB00233Aminosalicylic AcidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00260CycloserineAromatic-L-amino-acid decarboxylaseenzyme
DB00260CycloserineD-alanine--D-alanine ligase Atarget
DB00260CycloserineAlanine racemasetarget
DB00260CycloserineProton-coupled amino acid transporter 2transporter
DB00314Capreomycin70S ribosometarget
DB00609EthionamideCatalase-peroxidasetarget
DB00609EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB00701AmprenavirCytochrome P450 3A4enzyme
DB00701AmprenavirCytochrome P450 2B6enzyme
DB00701AmprenavirCytochrome P450 2C19enzyme
DB00701AmprenavirCytochrome P450 2C8enzyme
DB00701AmprenavirCytochrome P450 2C9enzyme
DB00701AmprenavirCytochrome P450 2D6enzyme
DB00701AmprenavirCytochrome P450 3A5enzyme
DB00701AmprenavirHuman immunodeficiency virus type 1 proteasetarget
DB00701AmprenavirMultidrug resistance protein 1transporter
DB00701AmprenavirMultidrug resistance-associated protein 1transporter
DB00701AmprenavirSolute carrier organic anion transporter family member 1B1transporter
DB01201RifapentineCytochrome P450 2C8enzyme
DB01201RifapentineCytochrome P450 2C9enzyme
DB01201RifapentineCytochrome P450 3A4enzyme
DB01201RifapentineCytochrome P450 2D6enzyme
DB01201RifapentineCytochrome P450 3A43enzyme
DB01201RifapentineCytochrome P450 2C19enzyme
DB01201RifapentineCytochrome P450 2B6enzyme
DB01201RifapentineDNA-directed RNA polymerase subunit beta'target
DB01208SparfloxacinCytochrome P450 1A2enzyme
DB01208SparfloxacinDNA gyrase subunit Atarget
DB01208SparfloxacinDNA topoisomerase 4 subunit Atarget
DB01208SparfloxacinDNA topoisomerase 2-alphatarget
DB01208SparfloxacinSolute carrier family 22 member 5transporter
DB01208SparfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinMultidrug resistance protein 1transporter
DB04934RifalazilCytochrome P450 3A4enzyme
DB04934RifalazilDNA-directed RNA polymerase subunit betatarget
DB06827Viomycin70S ribosometarget
DB08903BedaquilineCytochrome P450 3A4enzyme
DB08903BedaquilineATP synthase subunit ctarget
DB09499Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
DB11774PazufloxacinCytochrome P450 1A2enzyme
DB00330EthambutolProbable arabinosyltransferase Btarget
DB00330EthambutolProbable arabinosyltransferase Atarget
DB00330EthambutolProbable arabinosyltransferase Ctarget
DB00339PyrazinamideXanthine dehydrogenase/oxidaseenzyme
DB00339PyrazinamideAldehyde oxidaseenzyme
DB00339PyrazinamideCytochrome P450 3A4enzyme
DB00339PyrazinamideFatty acid synthetase I (FASI)target
DB00615RifabutinCytochrome P450 3A4enzyme
DB00615RifabutinCytochrome P450 2C19enzyme
DB00615RifabutinCytochrome P450 2B6enzyme
DB00615RifabutinCytochrome P450 2C8enzyme
DB00615RifabutinCytochrome P450 2C9enzyme
DB00615RifabutinCytochrome P450 2D6enzyme
DB00615RifabutinDNA-directed RNA polymerase subunit alphatarget
DB00615RifabutinHeat shock protein HSP 90-alphatarget
DB00615RifabutinEndoplasmintarget
DB00615RifabutinDNA-directed RNA polymerase subunit betatarget
DB00615RifabutinDNA-directed RNA polymerase subunit beta'target
DB00951IsoniazidSerum albumincarrier
DB00951IsoniazidCytochrome P450 2E1enzyme
DB00951IsoniazidCytochrome P450 1A2enzyme
DB00951IsoniazidCytochrome P450 2C9enzyme
DB00951IsoniazidCytochrome P450 2D6enzyme
DB00951IsoniazidCytochrome P450 2C19enzyme
DB00951IsoniazidCytochrome P450 3A4enzyme
DB00951IsoniazidArylamine N-acetyltransferase 2enzyme
DB00951IsoniazidArylamine N-acetyltransferaseenzyme
DB00951IsoniazidCytochrome P450 2A6enzyme
DB00951IsoniazidCytochrome P450 2C8enzyme
DB00951IsoniazidCatalase-peroxidasetarget
DB00951IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB00951IsoniazidCytochrome P450 2C8target
DB00951IsoniazidCytochrome P450 1A2target
DB00951IsoniazidCytochrome P450 3A4target
DB00951IsoniazidCytochrome P450 2C19target
DB00951IsoniazidDihydrofolate reductasetarget
DB01045RifampicinCytochrome P450 3A4enzyme
DB01045RifampicinCytochrome P450 1A2enzyme
DB01045RifampicinCytochrome P450 2C8enzyme
DB01045RifampicinUDP-glucuronosyltransferase 1-1enzyme
DB01045RifampicinCytochrome P450 2C9enzyme
DB01045RifampicinCytochrome P450 2B6enzyme
DB01045RifampicinCytochrome P450 2C19enzyme
DB01045RifampicinCytochrome P450 2A6enzyme
DB01045RifampicinCytochrome P450 2E1enzyme
DB01045RifampicinCytochrome P450 3A43enzyme
DB01045RifampicinCytochrome P450 3A7enzyme
DB01045RifampicinCytochrome P450 4A11enzyme
DB01045RifampicinCytochrome P450 2D6enzyme
DB01045RifampicinDNA-directed RNA polymerase subunit betatarget
DB01045RifampicinNuclear receptor subfamily 1 group I member 2target
DB01045RifampicinDNA-directed RNA polymerase subunit beta'target
DB01045RifampicinSolute carrier organic anion transporter family member 1B1target
DB01045RifampicinSolute carrier organic anion transporter family member 1A2target
DB01045RifampicinSolute carrier organic anion transporter family member 1B3target
DB01045RifampicinLanosterol 14-alpha demethylasetarget
DB01045RifampicinSerum albumintarget
DB01045RifampicinSolute carrier organic anion transporter family member 2B1target
DB01045RifampicinCanalicular multispecific organic anion transporter 2transporter
DB01045RifampicinMultidrug resistance-associated protein 5transporter
DB01045RifampicinMultidrug resistance protein 1transporter
DB01045RifampicinCanalicular multispecific organic anion transporter 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 2B1transporter
DB01045RifampicinBile salt export pumptransporter
DB01045RifampicinMultidrug resistance-associated protein 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1A2transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinSolute carrier family 22 member 7transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B1transporter
DB01045RifampicinSolute carrier family 22 member 6transporter
DB01045RifampicinSolute carrier family 22 member 8transporter