You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameIsoniazid
Accession NumberDB00951  (APRD01055, EXPT01940)
TypeSmall Molecule
GroupsApproved
DescriptionAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. [PubChem]
Structure
Thumb
Synonyms
4-pyridinecarbohydrazide
INH
Isoniazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinylhydrazine
Pyridine-4-carboxylic acid hydrazide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dom-isoniazid 300mg TabletsTablet300 mgOralDominion Pharmacal1995-12-31Not applicableCanada
IsoniazidTablet300 mg/1OralPd Rx Pharmaceuticals, Inc.1978-12-11Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2011-06-212016-10-13Us
IsoniazidTablet300 mg/1OralEon Labs, Inc.1978-12-11Not applicableUs
IsoniazidTablet300 mg/1OralPreferred Pharmaceuticals Inc.2015-10-07Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2016-05-04Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2011-07-192016-10-28Us
IsoniazidTablet100 mg/1OralEon Labs, Inc.1978-12-11Not applicableUs
IsoniazidTablet300 mg/1OralREMEDYREPACK INC.2011-12-07Not applicableUs
IsoniazidTablet100 mg/1OralPd Rx Pharmaceuticals, Inc.1978-12-11Not applicableUs
IsoniazidTablet300 mg/1OralREMEDYREPACK INC.2013-05-28Not applicableUs
Isoniazid Syrup 50mg/5mlSyrup50 mgOralCarolina Medical Products Company1987-12-311999-07-26Canada
Isoniazid Tab 100mgTablet100 mgOralSands Pharm1980-12-311996-09-10Canada
Isoniazid Tab 300mgTablet300 mgOralSands Pharm1974-12-311996-09-10Canada
Isoniazid Tab 50mgTablet50 mgOralSands Pharm1976-12-311996-09-10Canada
Isoniazide 100mg TabletsTablet100 mgOralLaboratoires Confab IncNot applicableNot applicableCanada
Isotamine PowderPowder500 gOralValeant Canada Lp Valeant Canada S.E.C.1976-12-31Not applicableCanada
Isotamine Syr Pediatric 50mg/5mlSyrup10 mgOralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Isotamine-100Tablet100 mgOralValeant Canada Lp Valeant Canada S.E.C.1972-12-31Not applicableCanada
Isotamine-300Tablet300 mgOralValeant Canada Lp Valeant Canada S.E.C.1972-12-31Not applicableCanada
Pdp-isoniazidTablet300 mgOralPendopharm Division Of De Pharmascience Inc1984-12-31Not applicableCanada
Pdp-isoniazidTablet50 mgOralPendopharm Division Of De Pharmascience Inc1986-12-31Not applicableCanada
Pdp-isoniazidTablet100 mgOralPendopharm Division Of De Pharmascience Inc1984-12-31Not applicableCanada
Pdp-isoniazidSolution50 mgOralPendopharm Division Of De Pharmascience Inc1984-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IsoniazidTablet300 mg/1OralA S Medication Solutions Llc1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralBlenheim Pharmacal, Inc.2010-03-09Not applicableUs
IsoniazidSolution50 mg/5mLOralDepartment Of State Health Services, Pharmacy Branch1983-11-11Not applicableUs
IsoniazidTablet100 mg/1Oralbryant ranch prepack1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralA S Medication Solutions2013-10-10Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2011-09-06Not applicableUs
IsoniazidTablet300 mg/1OralLiberty Pharmaceuticals, Inc.1972-09-01Not applicableUs
IsoniazidSolution50 mg/5mLOralCarolina Medical Products Company1983-11-11Not applicableUs
IsoniazidTablet300 mg/1OralREMEDYREPACK INC.2011-09-27Not applicableUs
IsoniazidTablet300 mg/1OralVersa Pharm Incorporated1997-09-01Not applicableUs
IsoniazidTablet300 mg/1OralMajor Pharmaceuticals1972-02-28Not applicableUs
IsoniazidTablet300 mg/1OralAmerican Health Packaging2013-10-10Not applicableUs
IsoniazidTablet100 mg/1OralWest Ward Pharmaceuticals Corp1972-02-28Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2014-05-27Not applicableUs
IsoniazidTablet300 mg/1OralSTAT Rx USA LLC2010-10-20Not applicableUs
IsoniazidTablet300 mg/1OralDepartment Of State Health Services, Pharmacy Branch1972-09-01Not applicableUs
IsoniazidSolution50 mg/5mLOralA S Medication Solutions Llc1983-11-11Not applicableUs
IsoniazidTablet300 mg/1OralLiberty Pharmaceuticals, Inc.1981-07-14Not applicableUs
IsoniazidTablet300 mg/1OralContract Pharmacy Services Pa2010-08-02Not applicableUs
IsoniazidTablet300 mg/1OralA S Medication Solutions1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralREMEDYREPACK INC.2013-03-012016-10-20Us
IsoniazidSyrup50 mg/5mLOralMikart, Inc.1997-07-21Not applicableUs
IsoniazidTablet100 mg/1OralPd Rx Pharmaceuticals, Inc.1972-02-28Not applicableUs
IsoniazidTablet100 mg/1OralVersa Pharm Incorporated1997-09-01Not applicableUs
IsoniazidTablet300 mg/1OralBlenheim Pharmacal, Inc.2012-09-14Not applicableUs
IsoniazidTablet300 mg/1OralMarlex Pharmaceuticals Inc2014-10-01Not applicableUs
IsoniazidTablet300 mg/1OralWest Ward Pharmaceuticals Corp1981-07-14Not applicableUs
IsoniazidTablet300 mg/1OralH.J. Harkins Company, Inc.1981-07-14Not applicableUs
IsoniazidTablet300 mg/1OralRebel Distributors Corp1981-07-14Not applicableUs
IsoniazidTablet100 mg/1OralTeva Pharmaceuticals Usa, Inc.1972-09-01Not applicableUs
IsoniazidTablet100 mg/1OralA S Medication Solutions Llc1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralLannett Company, Inc.2013-10-10Not applicableUs
IsoniazidTablet300 mg/1OralPreferred Pharmaceuticals, Inc.2004-08-30Not applicableUs
IsoniazidTablet100 mg/1OralA S Medication Solutions1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralMylan Institutional Inc.1994-06-09Not applicableUs
IsoniazidTablet100 mg/1OralMikart, Inc.1997-06-26Not applicableUs
IsoniazidTablet100 mg/1OralClinical Solutions Wholesale1972-09-01Not applicableUs
IsoniazidSolution50 mg/5mLOralbryant ranch prepack1983-11-11Not applicableUs
IsoniazidTablet300 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
IsoniazidTablet300 mg/1OralBlenheim Pharmacal, Inc.2013-06-28Not applicableUs
IsoniazidTablet100 mg/1OralDepartment Of State Health Services, Pharmacy Branch1972-09-01Not applicableUs
IsoniazidTablet100 mg/1OralREMEDYREPACK INC.2014-06-18Not applicableUs
IsoniazidTablet300 mg/1OralPd Rx Pharmaceuticals, Inc.1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralTeva Pharmaceuticals Usa, Inc.1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralPhysicians Total Care, Inc.1972-09-01Not applicableUs
IsoniazidInjection, solution100 mg/mLIntramuscularSandoz Inc2006-01-19Not applicableUs
IsoniazidTablet300 mg/1OralPreferred Pharmaceuticals, Inc.2014-11-03Not applicableUs
IsoniazidTablet300 mg/1OralNu Care Pharmaceuticals, Inc.1972-09-01Not applicableUs
IsoniazidTablet300 mg/1OralNorthwind Pharmaceuticals, LLC2014-07-14Not applicableUs
IsoniazidTablet300 mg/1Oralbryant ranch prepack1981-07-14Not applicableUs
IsoniazidTablet300 mg/1OralMikart, Inc.1997-06-26Not applicableUs
IsoniazidTablet300 mg/1OralClinical Solutions Wholesale1972-09-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
NicozidPiam
NidrazidZentiva
NydrazidSandoz
RimicidSopharma
RimifonRoche
ServizidNovartis
TibinideMeda
Brand mixtures
NameLabellerIngredients
IsonarifVersa Pharm Incorporated
Isotamine B 300Valeant Canada Lp Valeant Canada S.E.C.
RifamateSanofi Aventis U.S. Llc
RifaterREMEDYREPACK INC.
SaltsNot Available
Categories
UNIIV83O1VOZ8L
CAS number54-85-3
WeightAverage: 137.1393
Monoisotopic: 137.058911861
Chemical FormulaC6H7N3O
InChI KeyQRXWMOHMRWLFEY-UHFFFAOYSA-N
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
IUPAC Name
pyridine-4-carbohydrazide
SMILES
NNC(=O)C1=CC=NC=C1
Pharmacology
IndicationFor the treatment of all forms of tuberculosis in which organisms are susceptible.
Structured Indications
PharmacodynamicsIsoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. Isoniazid is bactericidal to rapidly-dividing mycobacteria, but is bacteriostatic if the mycobacterium is slow-growing.
Mechanism of actionIsoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
TargetKindPharmacological actionActionsOrganismUniProt ID
Catalase-peroxidaseProteinyes
other/unknown
Mycobacterium tuberculosisQ08129 details
Enoyl-[acyl-carrier-protein] reductase [NADH]Proteinyes
adduct
Mycobacterium tuberculosisP0A5Y6 details
Cytochrome P450 2C8ProteinunknownNot AvailableHumanP10632 details
Cytochrome P450 1A2ProteinunknownNot AvailableHumanP05177 details
Cytochrome P450 3A4ProteinunknownNot AvailableHumanP08684 details
Cytochrome P450 2C19ProteinunknownNot AvailableHumanP33261 details
Dihydrofolate reductaseProteinunknownNot AvailableMycobacterium tuberculosisP0A546 details
Related Articles
AbsorptionReadily absorbed following oral administration; however, may undergo significant first pass metabolism. Absorption and bioavailability are reduced when isoniazid is administered with food.
Volume of distributionNot Available
Protein bindingVery low (0-10%)
Metabolism

Primarily hepatic. Isoniazid is acetylated by N -acetyl transferase to N -acetylisoniazid; it is then biotransformed to isonicotinic acid and monoacetylhydrazine. Monoacetylhydrazine is associated with hepatotoxicity via formation of a reactive intermediate metabolite when N-hydroxylated by the cytochrome P450 mixed oxidase system. The rate of acetylation is genetically determined. Slow acetylators are characterized by a relative lack of hepatic N -acetyltransferase.

Route of eliminationFrom 50 to 70 percent of a dose of isoniazid is excreted in the urine within 24 hours.
Half lifeFast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours.
ClearanceNot Available
ToxicityLD50 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.
Affected organisms
  • Mycobacteria
  • Mycobacterium tuberculosis
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2E1
Gene symbol: CYP2E1
UniProt: P05181
rs6413419 CYP2E1 *1AG Allele, homozygoteHepatotoxicity16770646
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of Isoniazid can be decreased when it is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe serum concentration of Isoniazid can be decreased when it is combined with 19-norandrostenedione.Experimental, Illicit
4-AndrostenedioneThe serum concentration of Isoniazid can be decreased when it is combined with 4-Androstenedione.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Isoniazid.Experimental, Illicit
5-androstenedioneThe serum concentration of Isoniazid can be decreased when it is combined with 5-androstenedione.Experimental, Illicit
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Isoniazid.Approved
AcetaminophenThe risk or severity of adverse effects can be increased when Isoniazid is combined with Acetaminophen.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Isoniazid.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Isoniazid.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Isoniazid.Approved
AlclometasoneThe serum concentration of Isoniazid can be decreased when it is combined with Alclometasone.Approved
AldosteroneThe serum concentration of Isoniazid can be decreased when it is combined with Aldosterone.Experimental
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Isoniazid.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Isoniazid.Approved
AlprenololThe metabolism of Alprenolol can be decreased when combined with Isoniazid.Approved, Withdrawn
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Aluminum phosphateAluminum phosphate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Isoniazid.Approved, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be increased when it is combined with Isoniazid.Experimental
AmcinonideThe serum concentration of Isoniazid can be decreased when it is combined with Amcinonide.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Isoniazid.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Isoniazid.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Isoniazid.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Isoniazid.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Isoniazid.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Isoniazid.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Isoniazid.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Isoniazid.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Isoniazid.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Isoniazid.Approved
AnecortaveThe serum concentration of Isoniazid can be decreased when it is combined with Anecortave.Investigational
AnilineThe metabolism of Aniline can be decreased when combined with Isoniazid.Experimental
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Isoniazid.Approved
ApixabanThe metabolism of Apixaban can be decreased when combined with Isoniazid.Approved
AprepitantThe metabolism of Aprepitant can be decreased when combined with Isoniazid.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Isoniazid.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Isoniazid.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Isoniazid.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Isoniazid.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Isoniazid resulting in a loss in efficacy.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Isoniazid.Approved, Withdrawn
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Isoniazid.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Isoniazid.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Isoniazid.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Isoniazid.Investigational
BeclomethasoneThe serum concentration of Isoniazid can be decreased when it is combined with Beclomethasone.Investigational
Beclomethasone dipropionateThe serum concentration of Isoniazid can be decreased when it is combined with Beclomethasone dipropionate.Approved, Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Isoniazid.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Isoniazid.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Isoniazid.Approved, Withdrawn
BetamethasoneThe serum concentration of Isoniazid can be decreased when it is combined with Betamethasone.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Isoniazid.Approved
Bismuth SubcitrateBismuth Subcitrate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Isoniazid.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Isoniazid.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Isoniazid.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Isoniazid.Approved, Illicit
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Isoniazid.Approved
BudesonideThe serum concentration of Isoniazid can be decreased when it is combined with Budesonide.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Isoniazid.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Isoniazid.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Isoniazid.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Isoniazid.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Isoniazid.Approved, Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Isoniazid.Approved
Calcium carbonateCalcium carbonate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CapsaicinThe metabolism of Capsaicin can be decreased when combined with Isoniazid.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Isoniazid.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Isoniazid.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Isoniazid.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Isoniazid.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Isoniazid.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Isoniazid.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Isoniazid.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Isoniazid.Approved, Vet Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Isoniazid.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Isoniazid.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Isoniazid.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Isoniazid.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Isoniazid.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Isoniazid.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Isoniazid.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Isoniazid.Approved
CiclesonideThe serum concentration of Isoniazid can be decreased when it is combined with Ciclesonide.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Isoniazid.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Isoniazid.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Isoniazid.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Isoniazid.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Isoniazid.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Isoniazid.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Isoniazid.Approved, Illicit
ClobetasolThe serum concentration of Isoniazid can be decreased when it is combined with Clobetasol.Investigational
Clobetasol propionateThe serum concentration of Isoniazid can be decreased when it is combined with Clobetasol propionate.Approved
ClocortoloneThe serum concentration of Isoniazid can be decreased when it is combined with Clocortolone.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Isoniazid.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Isoniazid.Approved, Vet Approved
ClonidineThe metabolism of Clonidine can be decreased when combined with Isoniazid.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Isoniazid resulting in a loss in efficacy.Approved, Nutraceutical
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Isoniazid.Approved, Illicit
ClotrimazoleThe metabolism of Isoniazid can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Isoniazid.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Isoniazid.Approved, Illicit
Cortisone acetateThe serum concentration of Isoniazid can be decreased when it is combined with Cortisone acetate.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Isoniazid.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Isoniazid.Approved, Investigational
CycloserineThe risk or severity of adverse effects can be increased when Isoniazid is combined with Cycloserine.Approved
Cyproterone acetateThe serum concentration of Isoniazid can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Isoniazid.Approved, Investigational
DalfampridineThe metabolism of Dalfampridine can be decreased when combined with Isoniazid.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Isoniazid.Approved
DapsoneThe metabolism of Dapsone can be decreased when combined with Isoniazid.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Isoniazid.Approved, Investigational
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Isoniazid.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Isoniazid.Approved
dehydroepiandrosterone sulfateThe serum concentration of Isoniazid can be decreased when it is combined with dehydroepiandrosterone sulfate.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Isoniazid.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Isoniazid.Approved
DesoximetasoneThe serum concentration of Isoniazid can be decreased when it is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe serum concentration of Isoniazid can be decreased when it is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe serum concentration of Isoniazid can be decreased when it is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DexamethasoneThe serum concentration of Isoniazid can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Isoniazid can be decreased when it is combined with Dexamethasone isonicotinate.Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Isoniazid.Approved, Illicit, Withdrawn
DexmedetomidineThe metabolism of Dexmedetomidine can be decreased when combined with Isoniazid.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Isoniazid.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Isoniazid.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Isoniazid.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Isoniazid.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Isoniazid.Approved, Vet Approved
DiflorasoneThe serum concentration of Isoniazid can be decreased when it is combined with Diflorasone.Approved
DifluocortoloneThe serum concentration of Isoniazid can be decreased when it is combined with Difluocortolone.Approved
DifluprednateThe serum concentration of Isoniazid can be decreased when it is combined with Difluprednate.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Isoniazid.Approved, Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Isoniazid.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Isoniazid.Approved
DisulfiramThe risk or severity of adverse effects can be increased when Disulfiram is combined with Isoniazid.Approved
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Isoniazid.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Isoniazid.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Isoniazid.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Isoniazid.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Isoniazid.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Isoniazid.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Isoniazid.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Isoniazid.Approved, Investigational
DronabinolThe metabolism of Dronabinol can be decreased when combined with Isoniazid.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Isoniazid.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Isoniazid.Approved
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Isoniazid.Approved
EletriptanThe metabolism of Eletriptan can be decreased when combined with Isoniazid.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Isoniazid.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Isoniazid.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Isoniazid.Investigational
EnfluraneThe metabolism of Enflurane can be decreased when combined with Isoniazid.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Isoniazid.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Isoniazid.Approved, Investigational
EquileninThe serum concentration of Isoniazid can be decreased when it is combined with Equilenin.Experimental
EquilinThe serum concentration of Isoniazid can be decreased when it is combined with Equilin.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Isoniazid.Approved, Investigational
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Isoniazid.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Isoniazid.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Isoniazid.Approved, Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Isoniazid can be decreased when it is combined with Estrone.Approved
Estrone sulfateThe serum concentration of Isoniazid can be decreased when it is combined with Estrone sulfate.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Isoniazid.Approved
Ethanolamine OleateThe metabolism of Ethanolamine Oleate can be decreased when combined with Isoniazid.Approved
EthionamideThe serum concentration of Isoniazid can be increased when it is combined with Ethionamide.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Isoniazid.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Isoniazid.Approved, Illicit
EtoposideThe metabolism of Etoposide can be decreased when combined with Isoniazid.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Isoniazid.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Isoniazid.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Isoniazid.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Isoniazid.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Isoniazid.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Isoniazid.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Isoniazid.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Isoniazid.Approved
fluasteroneThe serum concentration of Isoniazid can be decreased when it is combined with fluasterone.Investigational
FludrocortisoneThe serum concentration of Isoniazid can be decreased when it is combined with Fludrocortisone.Approved
FlumethasoneThe serum concentration of Isoniazid can be decreased when it is combined with Flumethasone.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Isoniazid.Approved
FlunisolideThe serum concentration of Isoniazid can be decreased when it is combined with Flunisolide.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Isoniazid.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Isoniazid can be decreased when it is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Isoniazid can be decreased when it is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe serum concentration of Isoniazid can be decreased when it is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe serum concentration of Isoniazid can be decreased when it is combined with Fluorometholone.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Isoniazid.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Isoniazid.Approved
FluprednideneThe serum concentration of Isoniazid can be decreased when it is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe serum concentration of Isoniazid can be decreased when it is combined with Fluprednisolone.Approved
FlurandrenolideThe serum concentration of Isoniazid can be decreased when it is combined with Flurandrenolide.Approved
FlutamideThe metabolism of Flutamide can be decreased when combined with Isoniazid.Approved
Fluticasone furoateThe serum concentration of Isoniazid can be decreased when it is combined with Fluticasone furoate.Approved
Fluticasone PropionateThe serum concentration of Isoniazid can be decreased when it is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Isoniazid.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Isoniazid.Approved, Investigational
Folic AcidThe metabolism of Folic Acid can be decreased when combined with Isoniazid.Approved, Nutraceutical, Vet Approved
FormestaneThe serum concentration of Isoniazid can be decreased when it is combined with Formestane.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Isoniazid.Approved, Investigational
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Isoniazid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Isoniazid.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Isoniazid.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Isoniazid.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Isoniazid.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Isoniazid.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Isoniazid.Approved, Investigational
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Isoniazid.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Isoniazid.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Isoniazid.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Isoniazid.Approved, Vet Approved
HE3286The serum concentration of Isoniazid can be decreased when it is combined with HE3286.Investigational
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Isoniazid.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Isoniazid.Approved, Illicit
HydrocortisoneThe serum concentration of Isoniazid can be decreased when it is combined with Hydrocortisone.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Isoniazid.Approved, Illicit
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Isoniazid.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Isoniazid.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Isoniazid.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Isoniazid.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Isoniazid.Approved
ImatinibThe metabolism of Imatinib can be decreased when combined with Isoniazid.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Isoniazid.Approved
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Isoniazid.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Isoniazid.Approved
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Isoniazid.Approved, Vet Approved
IstaroximeThe serum concentration of Isoniazid can be decreased when it is combined with Istaroxime.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Isoniazid.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Isoniazid.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Isoniazid.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Isoniazid.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Isoniazid.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Isoniazid.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Isoniazid.Approved, Investigational
LevodopaThe therapeutic efficacy of Levodopa can be decreased when used in combination with Isoniazid.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Isoniazid.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Isoniazid.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Isoniazid.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Isoniazid.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Isoniazid.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Isoniazid.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Isoniazid.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Isoniazid.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Isoniazid.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Isoniazid.Approved
MagaldrateMagaldrate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium hydroxideMagnesium hydroxide can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Isoniazid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Isoniazid.Approved
ME-609The serum concentration of Isoniazid can be decreased when it is combined with ME-609.Investigational
MedrysoneThe serum concentration of Isoniazid can be decreased when it is combined with Medrysone.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Isoniazid.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Isoniazid can be decreased when it is combined with Melengestrol.Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Isoniazid.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Isoniazid.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Isoniazid.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Isoniazid.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Isoniazid.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Isoniazid.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Isoniazid.Approved, Illicit
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Isoniazid.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Isoniazid.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Isoniazid.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Isoniazid.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Isoniazid.Approved
MethylprednisoloneThe serum concentration of Isoniazid can be decreased when it is combined with Methylprednisolone.Approved, Vet Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Isoniazid.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Isoniazid.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Isoniazid.Approved, Investigational
MexiletineThe metabolism of Mexiletine can be decreased when combined with Isoniazid.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Isoniazid.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Isoniazid.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Isoniazid.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Isoniazid.Approved
MitoxantroneThe metabolism of Mitoxantrone can be decreased when combined with Isoniazid.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Isoniazid.Approved
MometasoneThe serum concentration of Isoniazid can be decreased when it is combined with Mometasone.Approved, Vet Approved
MorphineThe metabolism of Morphine can be decreased when combined with Isoniazid.Approved, Investigational
NateglinideThe metabolism of Nateglinide can be decreased when combined with Isoniazid.Approved, Investigational
NCX 1022The serum concentration of Isoniazid can be decreased when it is combined with NCX 1022.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Isoniazid.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Isoniazid.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Isoniazid.Approved
NetupitantThe metabolism of Netupitant can be decreased when combined with Isoniazid.Approved
NevirapineThe metabolism of Nevirapine can be decreased when combined with Isoniazid.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Isoniazid.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Isoniazid.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Isoniazid.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Isoniazid.Approved
NilutamideThe metabolism of Nilutamide can be decreased when combined with Isoniazid.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Isoniazid.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Isoniazid.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Isoniazid.Approved, Vet Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Isoniazid.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Isoniazid.Approved, Investigational
Oleoyl estroneThe serum concentration of Isoniazid can be decreased when it is combined with Oleoyl estrone.Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Isoniazid.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Isoniazid.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Isoniazid.Approved, Investigational
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Isoniazid.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Isoniazid.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Isoniazid.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Isoniazid.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Isoniazid.Approved
ParamethasoneThe serum concentration of Isoniazid can be decreased when it is combined with Paramethasone.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Isoniazid.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Isoniazid.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Isoniazid.Approved
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Isoniazid.Approved, Vet Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Isoniazid.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Isoniazid.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Isoniazid.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Isoniazid.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Isoniazid.Approved, Withdrawn
PhenobarbitalThe metabolism of Phenobarbital can be decreased when combined with Isoniazid.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Isoniazid.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Isoniazid.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Isoniazid.Approved
PimozideThe serum concentration of Pimozide can be increased when it is combined with Isoniazid.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Isoniazid.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Isoniazid.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Isoniazid.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Isoniazid.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Isoniazid.Approved
PrasteroneThe serum concentration of Isoniazid can be decreased when it is combined with Prasterone.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Isoniazid.Approved
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Isoniazid.Approved, Vet Approved
PrednicarbateThe serum concentration of Isoniazid can be decreased when it is combined with Prednicarbate.Approved
PrednisoloneThe serum concentration of Isoniazid can be decreased when it is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe serum concentration of Isoniazid can be decreased when it is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe serum concentration of Isoniazid can be decreased when it is combined with Pregnenolone.Experimental
PrimidoneThe metabolism of Primidone can be decreased when combined with Isoniazid.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Isoniazid.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Isoniazid.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Isoniazid.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Isoniazid.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Isoniazid.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Isoniazid.Approved
PropacetamolIsoniazid may increase the hepatotoxic activities of Propacetamol.Approved
PropafenoneThe serum concentration of Isoniazid can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Isoniazid.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Isoniazid.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Isoniazid.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Isoniazid.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Isoniazid.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Isoniazid.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Isoniazid.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Isoniazid.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Isoniazid.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Isoniazid.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Isoniazid.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Isoniazid.Investigational
RifabutinRifabutin may increase the hepatotoxic activities of Isoniazid.Approved
RifampicinRifampicin may increase the hepatotoxic activities of Isoniazid.Approved
RifapentineRifapentine may increase the hepatotoxic activities of Isoniazid.Approved
RimexoloneThe serum concentration of Isoniazid can be decreased when it is combined with Rimexolone.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Isoniazid.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Isoniazid.Approved, Investigational
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Isoniazid.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Isoniazid.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Isoniazid.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Isoniazid.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Isoniazid.Approved, Investigational
SelegilineThe metabolism of Selegiline can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Isoniazid.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Isoniazid.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Isoniazid.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Isoniazid.Approved, Vet Approved
SildenafilThe metabolism of Sildenafil can be decreased when combined with Isoniazid.Approved, Investigational
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Isoniazid.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Isoniazid.Experimental
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Isoniazid.Approved, Vet Approved
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Isoniazid resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Isoniazid.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Isoniazid.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Isoniazid.Investigational, Withdrawn
TemazepamThe metabolism of Temazepam can be decreased when combined with Isoniazid.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Isoniazid.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Isoniazid.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Isoniazid.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Isoniazid.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Isoniazid.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Isoniazid.Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Isoniazid.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Isoniazid.Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Isoniazid.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Isoniazid.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Isoniazid.Approved
TimololThe metabolism of Timolol can be decreased when combined with Isoniazid.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Isoniazid.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Isoniazid.Approved, Investigational
TirapazamineThe metabolism of Tirapazamine can be decreased when combined with Isoniazid.Investigational
TixocortolThe serum concentration of Isoniazid can be decreased when it is combined with Tixocortol.Approved
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Isoniazid.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Isoniazid.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Isoniazid.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Isoniazid.Approved, Investigational
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Isoniazid.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Isoniazid.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Isoniazid.Approved, Investigational
TriamcinoloneThe serum concentration of Isoniazid can be decreased when it is combined with Triamcinolone.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Isoniazid.Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Isoniazid.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Isoniazid.Withdrawn
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Isoniazid.Approved
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Isoniazid.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Isoniazid.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Isoniazid.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Isoniazid.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Isoniazid.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Isoniazid.Approved, Investigational
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Isoniazid.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Isoniazid.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Isoniazid.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Isoniazid.Approved, Vet Approved
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Isoniazid.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Isoniazid.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Isoniazid.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Isoniazid.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Isoniazid.Approved, Investigational
Food Interactions
  • Avoid aged foods (cheese, red wine), pickled foods, cured foods (bacon/ham), chocolate, fava beans, beer, unless approved by your physician.
  • Avoid alcohol.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
  • Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.
References
Synthesis Reference

Costin Rentzea, Albrecht Harreus, Eberhard Ammermann, Gisela Lorenz, “Oxalyl hydrazide-hydroxamic acid derivatives, their preparation and their use as fungicides.” U.S. Patent US5399589, issued November, 1969.

US5399589
General ReferencesNot Available
External Links
ATC CodesJ04AM04J04AM02J04AM06J04AM01J04AM03J04AM05J04AC51J04AC01
AHFS Codes
  • 08:16.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.1 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9892
Blood Brain Barrier+0.9895
Caco-2 permeable+0.6959
P-glycoprotein substrateNon-substrate0.8315
P-glycoprotein inhibitor INon-inhibitor0.9778
P-glycoprotein inhibitor IINon-inhibitor0.996
Renal organic cation transporterNon-inhibitor0.9054
CYP450 2C9 substrateNon-substrate0.9088
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7557
CYP450 1A2 substrateInhibitor0.6482
CYP450 2C9 inhibitorNon-inhibitor0.9273
CYP450 2D6 inhibitorNon-inhibitor0.9443
CYP450 2C19 inhibitorNon-inhibitor0.9513
CYP450 3A4 inhibitorNon-inhibitor0.5111
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9342
Ames testAMES toxic0.8557
CarcinogenicityNon-carcinogens0.7514
BiodegradationNot ready biodegradable0.981
Rat acute toxicity2.0713 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9872
hERG inhibition (predictor II)Non-inhibitor0.9586
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Sandoz canada inc
  • Sandoz inc
  • Hoffmann la roche inc
  • Carolina medical products co
  • Mikart inc
  • Lannett co inc
  • Dow pharmaceutical corp sub dow chemical co
  • Medpointe pharmaceuticals medpointe healthcare inc
  • Novartis pharmaceuticals corp
  • Barr laboratories inc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Halsey drug co inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Eli lilly and co
  • Mk laboratories inc
  • Mutual pharmaceutical co inc
  • Nexgen pharma inc
  • Panray corp sub ormont drug and chemical co inc
  • L perrigo co
  • Pharmavite pharmaceuticals
  • Phoenix laboratories inc
  • Purepac pharmaceutical co
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
  • Bristol myers squibb co
  • Everylife
Packagers
Dosage forms
FormRouteStrength
TabletOral300 mg
CapsuleOral
Injection, solutionIntramuscular100 mg/mL
SolutionOral50 mg/5mL
SyrupOral50 mg/5mL
TabletOral100 mg/1
TabletOral300 mg/1
SyrupOral50 mg
TabletOral
PowderOral500 g
SyrupOral10 mg
TabletOral100 mg
SolutionOral50 mg
TabletOral50 mg
Tablet, sugar coatedOral
Prices
Unit descriptionCostUnit
Isoniazid 100 mg/ml vial27.37USD ml
Rifamate 150-300 mg capsule4.36USD capsule
Rifamate capsule4.19USD capsule
Isoniazid 100 mg tablet0.28USD tablet
Isoniazid 300 mg tablet0.18USD tablet
Isoniazid 50 mg/5ml Syrup0.16USD ml
Isoniazid powder0.11USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point171.4 °CPhysProp
water solubility1.4E+005 mg/L (at 25 °C)MERCK INDEX (2001)
logP-0.70HANSCH,C ET AL. (1995)
logS0.01ADME Research, USCD
pKa1.82 (at 20 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility34.9 mg/mLALOGPS
logP-0.71ALOGPS
logP-0.69ChemAxon
logS-0.59ALOGPS
pKa (Strongest Acidic)13.61ChemAxon
pKa (Strongest Basic)3.35ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area68.01 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity37.46 m3·mol-1ChemAxon
Polarizability13.21 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.21 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0kdr-9600000000-f04526999a9b68d31861View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPyridinecarboxylic acids and derivatives
Direct ParentPyridinecarboxylic acids and derivatives
Alternative Parents
Substituents
  • Pyridine carboxylic acid or derivatives
  • Heteroaromatic compound
  • Carboxylic acid hydrazide
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
yes
Actions
other/unknown
General Function:
Inorganic ion transport and metabolism
Specific Function:
Bifunctional, exhibiting both a catalase and broad- spectrum peroxidase activities. May play a role in the intracellular survival of mycobacteria
Gene Name:
katG
Uniprot ID:
Q08129
Molecular Weight:
80605.0 Da
References
  1. Pym AS, Domenech P, Honore N, Song J, Deretic V, Cole ST: Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol. 2001 May;40(4):879-89. [PubMed:11401695 ]
  2. Heym B, Alzari PM, Honore N, Cole ST: Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol. 1995 Jan;15(2):235-45. [PubMed:7746145 ]
  3. Wilson TM, de Lisle GW, Collins DM: Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol. 1995 Mar;15(6):1009-15. [PubMed:7623658 ]
  4. Vilcheze C, Jacobs WR Jr: The mechanism of isoniazid killing: clarity through the scope of genetics. Annu Rev Microbiol. 2007;61:35-50. [PubMed:18035606 ]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
yes
Actions
adduct
General Function:
Lipid transport and metabolism
Specific Function:
Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide
Gene Name:
inhA
Uniprot ID:
P0A5Y6
Molecular Weight:
28528.0 Da
References
  1. Schroeder EK, Basso LA, Santos DS, de Souza ON: Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities. Biophys J. 2005 Aug;89(2):876-84. Epub 2005 May 20. [PubMed:15908576 ]
  2. Wilson TM, de Lisle GW, Collins DM: Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol. 1995 Mar;15(6):1009-15. [PubMed:7623658 ]
  3. Broussy S, Coppel Y, Nguyen M, Bernadou J, Meunier B: 1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis. Chemistry. 2003 May 9;9(9):2034-8. [PubMed:12740851 ]
  4. Vilcheze C, Jacobs WR Jr: The mechanism of isoniazid killing: clarity through the scope of genetics. Annu Rev Microbiol. 2007;61:35-50. [PubMed:18035606 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Fontana E, Dansette PM, Poli SM: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. [PubMed:16248836 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Fontana E, Dansette PM, Poli SM: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. [PubMed:16248836 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Fontana E, Dansette PM, Poli SM: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. [PubMed:16248836 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Fontana E, Dansette PM, Poli SM: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. [PubMed:16248836 ]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
unknown
General Function:
Coenzyme transport and metabolism
Specific Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH
Gene Name:
folA
Uniprot ID:
P0A546
Molecular Weight:
17640.0 Da
References
  1. Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilcheze C, Jacobs WR Jr, Sacchettini JC: Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid. Antimicrob Agents Chemother. 2010 Sep;54(9):3776-82. doi: 10.1128/AAC.00453-10. Epub 2010 Jun 21. [PubMed:20566771 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Arylamine n-acetyltransferase activity
Specific Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:
NAT2
Uniprot ID:
P11245
Molecular Weight:
33542.235 Da
References
  1. Upton AM, Mushtaq A, Victor TC, Sampson SL, Sandy J, Smith DM, van Helden PV, Sim E: Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol Microbiol. 2001 Oct;42(2):309-17. [PubMed:11703656 ]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
unknown
Actions
inhibitor
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
nat
Uniprot ID:
P0A5L8
Molecular Weight:
Not Available
References
  1. Upton AM, Mushtaq A, Victor TC, Sampson SL, Sandy J, Smith DM, van Helden PV, Sim E: Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol Microbiol. 2001 Oct;42(2):309-17. [PubMed:11703656 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23