Acquired Immune Deficiency Syndrome (AIDS)

Also known as: Acquired Immune Deficiency Syndrome / AIDS / Acquired Immunodeficiency Syndrome / Acquired Immunodeficiency Syndromes / AIDS (Acquired Immune Deficiency Syndrome) / Acquired ImmunoDeficiency Syndrome (AIDS) / AIDS (Acquired Immunodeficiency Syndrome) / Syndromes, Acquired Immunodeficiency / Acquired immunodeficiency syndrome NOS / Acquired immune deficiency syndr / Acquired immuno deficiency syndrome / Acquired immunodeficiency syndrome, unspecified / Human immunodeficiency virus [HIV] disease (B20) / Autoimmune deficiency syndrome

DrugDrug NameDrug Description
DB00290BleomycinA complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
DB00369CidofovirCidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
DB00529FoscarnetAn antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
DB01004GanciclovirAn acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
DB00105Interferon alfa-2bInterferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
DB00351Megestrol acetate17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
DB01229PaclitaxelPaclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
DB01041ThalidomideA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
DB01610ValganciclovirValganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00290BleomycinDNA ligase 3target
DB00290BleomycinDNA ligase 1target
DB00290BleomycinDNAtarget
DB00290BleomycinBleomycin hydrolaseenzyme
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00369CidofovirThymidine phosphorylaseenzyme
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB01004GanciclovirDNA polymerase catalytic subunittarget
DB01004GanciclovirThymidine kinasetarget
DB01004GanciclovirSolute carrier family 22 member 1transporter
DB01004GanciclovirSolute carrier family 22 member 6transporter
DB01004GanciclovirSolute carrier family 22 member 8transporter
DB01004GanciclovirSolute carrier family 22 member 7transporter
DB01004GanciclovirDNAtarget
DB01004GanciclovirMultidrug and toxin extrusion protein 1transporter
DB01004GanciclovirMultidrug and toxin extrusion protein 2transporter
DB00105Interferon alfa-2bInterferon alpha/beta receptor 2target
DB00105Interferon alfa-2bInterferon alpha/beta receptor 1target
DB00105Interferon alfa-2bCytochrome P450 1A2enzyme
DB00351Megestrol acetateProgesterone receptortarget
DB00351Megestrol acetateGlucocorticoid receptortarget
DB00351Megestrol acetateMultidrug resistance protein 1transporter
DB00351Megestrol acetateCytochrome P450 3A4enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041ThalidomideNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DB01610ValganciclovirDNAtarget
DB01610ValganciclovirSolute carrier family 15 member 1transporter
DB01610ValganciclovirSolute carrier family 15 member 2transporter
DB01610ValganciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB01048Abacavir1Completed1
DB00701Amprenavir1Completed1
DB01008Busulfan1Recruiting1
DB01264Darunavir1Completed1
DB00879Emtricitabine1Completed1
DB00109Enfuvirtide1Completed1
DB06414Etravirine1Completed1
DB00224Indinavir1Completed1
DB00709Lamivudine1Completed1
DB00709Lamivudine1Unknown Status1
DB01601Lopinavir1Completed1
DB00238Nevirapine1Unknown Status1
DB05083Rilpivirine1Completed2
DB08864Rilpivirine1Completed2
DB00503Ritonavir1Completed2
DB09153Sodium chloride1Unknown Status1
DB00300Tenofovir disoproxil1Completed1
DB00495Zidovudine1Unknown Status1
DB06361rsPSMA Vaccine1Terminated1
DB05742AGS-0041 / 2Completed1
DB11908Dapivirine1 / 2Completed2
DB00704Naltrexone1 / 2Completed1
DB06013Aldoxorubicin2Completed1
DB01072Atazanavir2Completed1
DB11751Cabotegravir2Completed1
DB00608Chloroquine2Completed1
DB00169Cholecalciferol2Completed1
DB00369Cidofovir2Completed1
DB00515Cisplatin2Completed1
DB09065Cobicistat2Completed2
DB01264Darunavir2Completed1
DB00900Didanosine2Completed1
DB13018Dimiracetam2Completed1
DB13018Dimiracetam2Unknown Status1
DB00625Efavirenz2Completed3
DB09101Elvitegravir2Completed1
DB00879Emtricitabine2Completed2
DB00016Erythropoietin2Completed4
DB06414Etravirine2Completed2
DB00128L-Aspartic Acid2Completed1
DB00120L-Phenylalanine2Completed2
DB00709Lamivudine2Completed2
DB00583Levocarnitine2Completed1
DB00166Lipoic Acid2Completed1
DB14009Medical Cannabis2Not Yet Recruiting1
DB06817Raltegravir2Completed1
DB00503Ritonavir2Completed1
DB09299Tenofovir alafenamide2Completed2
DB00300Tenofovir disoproxil2Completed4
DB01041Thalidomide2Completed1
DB06652Vicriviroc2Completed1
DB00495Zidovudine2Completed1
DB01072Atazanavir2 / 3Recruiting1
DB09065Cobicistat2 / 3Completed1
DB09065Cobicistat2 / 3Recruiting1
DB01264Darunavir2 / 3Recruiting1
DB09101Elvitegravir2 / 3Completed1
DB09101Elvitegravir2 / 3Terminated1
DB00879Emtricitabine2 / 3Completed1
DB00120L-Phenylalanine2 / 3Recruiting1
DB09299Tenofovir alafenamide2 / 3Recruiting1
DB00300Tenofovir disoproxil2 / 3Completed1
DB00316Acetaminophen3Completed1
DB00681Amphotericin B3Completed1
DB01072Atazanavir3Completed3
DB01114Chlorphenamine3Completed1
DB09065Cobicistat3Completed8
DB01264Darunavir3Completed2
DB00514Dextromethorphan3Completed1
DB00625Efavirenz3Completed3
DB09101Elvitegravir3Completed7
DB00879Emtricitabine3Completed8
DB00109Enfuvirtide3Completed1
DB00330Ethambutol3Completed1
DB00529Foscarnet3Completed1
DB01004Ganciclovir3Completed1
DB01050Ibuprofen3Completed1
DB00951Isoniazid3Completed1
DB00125L-Arginine3Unknown Status1
DB00120L-Phenylalanine3Completed1
DB00709Lamivudine3Completed2
DB00709Lamivudine3Recruiting1
DB00709Lamivudine3Unknown Status1
DB01601Lopinavir3Completed1
DB01601Lopinavir3Unknown Status1
DB04835Maraviroc3Completed2
DB00238Nevirapine3Completed2
DB00238Nevirapine3Unknown Status1
DB00022Peginterferon alfa-2b3Completed1
DB00388Phenylephrine3Completed1
DB00339Pyrazinamide3Completed1
DB06817Raltegravir3Recruiting1
DB01045Rifampicin3Completed1
DB00503Ritonavir3Completed2
DB00503Ritonavir3Unknown Status1
DB00649Stavudine3Completed2
DB09299Tenofovir alafenamide3Completed3
DB00300Tenofovir disoproxil3Completed7
DB00300Tenofovir disoproxil3Unknown Status1
DB06652Vicriviroc3Completed2
DB06652Vicriviroc3Terminated1
DB00582Voriconazole3Completed1
DB00495Zidovudine3Completed2
DB00921Buprenorphine4Unknown Status1
DB11121Chloroxylenol4Unknown Status1
DB09065Cobicistat4Completed1
DB01264Darunavir4Completed1
DB01264Darunavir4Unknown Status1
DB00625Efavirenz4Completed2
DB00625Efavirenz4Terminated1
DB00625Efavirenz4Unknown Status1
DB00625Efavirenz4Withdrawn1
DB09101Elvitegravir4Completed1
DB00879Emtricitabine4Completed1
DB00879Emtricitabine4Terminated1
DB00879Emtricitabine4Withdrawn1
DB06414Etravirine4Completed1
DB00196Fluconazole4Completed1
DB00709Lamivudine4Completed3
DB00709Lamivudine4Unknown Status2
DB00583Levocarnitine4Completed1
DB01601Lopinavir4Active Not Recruiting1
DB01601Lopinavir4Completed1
DB01601Lopinavir4Terminated2
DB01601Lopinavir4Unknown Status2
DB04835Maraviroc4Completed2
DB04835Maraviroc4Terminated1
DB04835Maraviroc4Unknown Status1
DB00244Mesalazine4Completed1
DB00333Methadone4Completed1
DB00238Nevirapine4Completed2
DB11133Omega-3 fatty acids4Completed1
DB09539Omega-3-acid ethyl esters4Completed1
DB06817Raltegravir4Unknown Status1
DB00140Riboflavin4Completed1
DB00503Ritonavir4Active Not Recruiting1
DB00503Ritonavir4Completed1
DB00503Ritonavir4Terminated2
DB00503Ritonavir4Unknown Status2
DB00649Stavudine4Completed1
DB01015Sulfamethoxazole4Completed1
DB00300Tenofovir disoproxil4Completed1
DB00300Tenofovir disoproxil4Terminated1
DB00300Tenofovir disoproxil4Withdrawn1
DB00152Thiamine4Completed1
DB00440Trimethoprim4Completed1
DB00862Vardenafil4Completed1
DB00495Zidovudine4Completed1
DB00495Zidovudine4Unknown Status1
DB01072AtazanavirNot AvailableCompleted1
DB00921BuprenorphineNot AvailableActive Not Recruiting1
DB00921BuprenorphineNot AvailableCompleted1
DB01156BupropionNot AvailableRecruiting1
DB09065CobicistatNot AvailableRecruiting1
DB01264DarunavirNot AvailableRecruiting1
DB08930DolutegravirNot AvailableRecruiting1
DB00625EfavirenzNot AvailableCompleted1
DB00625EfavirenzNot AvailableTerminated1
DB00879EmtricitabineNot AvailableTerminated1
DB01175EscitalopramNot AvailableRecruiting1
DB00330EthambutolNot AvailableRecruiting1
DB01005HydroxyureaNot AvailableCompleted1
DB14618INFLUENZA A VIRUS A/BRISBANE/59/2007(H1N1) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)Not AvailableRecruiting1
DB14617INFLUENZA A VIRUS A/URUGUAY/716/2007(H3N2) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)Not AvailableRecruiting1
DB14385Influenza b virus b/brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB00951IsoniazidNot AvailableRecruiting1
DB00951IsoniazidNot AvailableTerminated1
DB01601LopinavirNot AvailableUnknown Status1
DB04835MaravirocNot AvailableCompleted1
DB00351Megestrol acetateNot AvailableCompleted1
DB01183NaloxoneNot AvailableActive Not Recruiting1
DB01183NaloxoneNot AvailableCompleted1
DB00704NaltrexoneNot AvailableCompleted1
DB00238NevirapineNot AvailableCompleted1
DB00717NorethisteroneNot AvailableCompleted1
DB01132PioglitazoneNot AvailableCompleted1
DB00339PyrazinamideNot AvailableRecruiting1
DB06817RaltegravirNot AvailableCompleted3
DB00615RifabutinNot AvailableRecruiting1
DB01045RifampicinNot AvailableRecruiting1
DB08864RilpivirineNot AvailableRecruiting1
DB00503RitonavirNot AvailableCompleted1
DB00503RitonavirNot AvailableUnknown Status1
DB09153Sodium chlorideNot AvailableCompleted1
DB00052SomatotropinNot AvailableCompleted1
DB14126TenofovirNot AvailableRecruiting1
DB00300Tenofovir disoproxilNot AvailableCompleted1
DB00300Tenofovir disoproxilNot AvailableTerminated1
DB09145WaterNot AvailableCompleted1