Identification
NameTolnaftate
Accession NumberDB00525  (APRD01607)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.

Structure
Thumb
Synonyms
2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
O-2-Naphthyl m,N-dimethylthiocarbanilate
Separin
Tinactin
Tolnaftato
Tolnaftatum
Tolnaphthate
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Absorbine Antifungal Powder 1%Powder1 %TopicalW.F. Young, Inc.1992-12-311997-07-28Canada
Absorbine Jr Antifungal LiquidLiquid10 mgTopicalClarion Brands, Llc1999-08-18Not applicableCanada
Aftate Athlete Foot CreamCream1 g/100gTopicalSabel Med Llc2016-05-01Not applicableUs
Anti-fungalPowder1 g/100gTopicalRugby2011-11-01Not applicableUs
Anti-fungalPowder.45 g/45gTopicalRij Pharmaceutical Corporation1999-03-16Not applicableUs
AntifungalCream10 mg/gTopicalUnifirst First Aid2002-06-30Not applicableUs
AntifungalCream10 mg/gTopicalMoore Medical2012-07-16Not applicableUs
AntifungalSpray1 g/100gTopicalRite Aid2016-05-12Not applicableUs
AntifungalSolution1 mg/100mLTopicalPerrigo New York Inc.2011-08-17Not applicableUs
AntifungalSolution1 mg/100mLTopicalPerrigo New York Inc.2005-12-06Not applicableUs
AntifungalCream1 g/100gTopicalRite Aid2005-07-23Not applicableUs
Antifungal CreamCream1 %TopicalPharmetics (2011) Inc.Not applicableNot applicableCanada
Antifungal Foot CareSpray1 g/100gTopicalRite Aid2004-09-24Not applicableUs
Athlete's Foot Gel 1%Gel1 %TopicalSchering Plough1982-12-312012-07-24Canada
Athlete's Foot Spray PowerSpray1 %TopicalEmpack Spraytech Inc.Not applicableNot applicableCanada
Athletes FootCream1 g/100gTopicalKroger2012-01-26Not applicableUs
Athletes FootSpray1 g/100gTopicalMeijer Distribution2004-10-26Not applicableUs
Athletes FootSpray1 g/100gTopicalWalgreen2004-09-10Not applicableUs
Athletes FootSpray1 g/100gTopicalCvs Health2016-11-11Not applicableUs
Athletes FootCream10 mg/gTopicalQuantum, Inc.2005-12-05Not applicableUs
Athletes FootCream1 g/100gTopicalCvs Health2005-06-09Not applicableUs
Athletes FootSpray1 g/100gTopicalMeijer Distribution2004-10-26Not applicableUs
Athletes FootSpray1 g/100gTopicalTaizhou Ludao Cosmetics Co., Ltd.2014-11-04Not applicableUs
Athletes FootSpray1 g/100gTopicalDolgencorp2014-11-04Not applicableUs
Athletes Foot Medicated AntifungalSpray1 g/100gTopicalWalgreen2004-09-10Not applicableUs
Athletes Foot QuinsanaPowder1 g/100gTopicalProduct Quest Mfg.2015-06-15Not applicableUs
Athletes Foot Spray Dr. FootAerosol1 g/100gTopicalBlue Cross Laboratories2010-10-19Not applicableUs
Atopalm Tolnaftate AntifungalCream1 g/100gTopicalNeopharm Co., Ltd2011-03-16Not applicableUs
Avon Foot Works Therapeutic Antifungal Foot CreamCream1 %TopicalAvon Products, Inc.2004-03-012011-08-05Canada
Avon Footworks Antifungal and Deodorant PowderPowder1 %TopicalAvon Products, Inc.1998-07-162006-01-27Canada
Avon Footworks Antifungal Foot SprayLiquid1 %TopicalAvon Products, Inc.1998-07-162012-07-25Canada
Barielle Fungus Rx Maximum Strength Anti-fungalSolution1 mL/100mLTopicalFisk Industries2012-01-01Not applicableUs
Barielle Professional Maximum Strength Fungus Rx Antifungal ProSolution1 mL/100mLTopicalFisk Industries2012-01-01Not applicableUs
Bengama AntifungalSolution1 mg/100mLTopicalGenuine Drugs2015-04-20Not applicableUs
Bio-scriptives Extreme AFCream.56 g/56.69gTopicalBio Chemics, Inc.2011-07-27Not applicableUs
Blistex Odor-eaters PowderSpray1 g/100gTopicalBlistex Corporation2013-12-09Not applicableUs
Canesten PowderPowder1 %TopicalBayer Inc Consumer CareNot applicableNot applicableCanada
Careall TolnaftateCream10 mg/gTopicalNew World Imports2012-06-01Not applicableUs
Cidacin Antifungal TreatmentSolution1 g/100mLTopicalPedicis Research, Llc2012-06-07Not applicableUs
Clarus AntifungalCream1 g/100gTopicalClinical Therapeutic Solutions2012-06-07Not applicableUs
Clarus AntifungalSolution1 g/100mLTopicalClinical Therapeutic Solutions2012-06-07Not applicableUs
Cvs Athletes Foot Cream .5ozCream10 mg/gTopicalCvs Health2014-10-13Not applicableUs
Cvs Athletes Foot TolnaftateCream10 mg/gTopicalCvs Health2014-10-10Not applicableUs
Cvs Health Antifungal Anthletes FootSpray10 mg/gTopicalFormulated Solutions, Llc2017-02-09Not applicableUs
Defense Antifungal Medicated BarSoap1 g/100gTopicalDefense Soap Llc2016-08-01Not applicableUs
Dg Athletes FootCream10 mg/gTopicalTAI GUK PHARM. CO., LTD.2010-12-10Not applicableUs
Dg Health Athletes FootCream10 mg/gTopicalDolgencorp2015-11-05Not applicableUs
Dr Canuso Fungal Nail EraserOil.14 g/14gTopicalRenu Laboratories, Inc.2015-08-11Not applicableUs
Dr. Canuso Foot Repair SerumLotion.3 g/28gTopicalRenu Laboratories, Inc.2015-08-20Not applicableUs
Dr. Gs Clear NailLiquid10 mg/mLTopicalPacific World Corporation2013-04-24Not applicableUs
Dr. Scholl's Athlete's Foot Powder - 1%Powder1 %TopicalSchering Plough1997-01-212012-07-24Canada
Dr. Scholl's Athlete's Foot Spray PowderAerosol; Powder1 %TopicalBayer Inc Consumer Care1989-12-31Not applicableCanada
Dr. Scholls Odor-X Foot and SneakerAerosol, powder10 mg/gTopicalBayer1993-09-23Not applicableUs
Equaline Athletes FootSpray1 g/100gTopicalSupervalu2004-09-11Not applicableUs
Equaline Athletes FootSpray1 g/100gTopicalSupervalu2004-09-11Not applicableUs
Equaline Tolnaftate AntifungalCream10 mg/gTopicalSupervalu2011-09-28Not applicableUs
Equate Athletes FootCream10 mg/gTopicalWalmart Stores2006-02-17Not applicableUs
Equate Athletes FootSpray1 g/100gTopicalWalmart Stores2004-09-07Not applicableUs
Equate Athletes Foot PowderSpray1 g/100gTopicalWalmart Stores2004-09-29Not applicableUs
Equate Liquid FootSpray1 g/150gTopicalTaizhou Ludao Cosmetics Co., Ltd.2014-07-01Not applicableUs
Equate Liquid FootSpray1 g/150gTopicalWalmart Stores2014-07-01Not applicableUs
Ez ClearCream1 %TopicalPromotion Eco St Clair Inc.Not applicableNot applicableCanada
Family Care TolnaftateCream10 mg/gTopicalUnited Exchange Corporation2013-04-30Not applicableUs
Family Wellness AntifungalCream1 g/100gTopicalFamily Dollar2014-01-21Not applicableUs
Family Wellness AntifungalCream1 g/100gTopicalFamily Dollar2014-01-21Not applicableUs
First Aid Antifungal Medicated Cream 0.5 OzCream10 mg/gTopicalFirst Aid Research Corporation2014-10-09Not applicableUs
First Aid Antifungal Medicated Cream 1ozCream10 mg/gTopicalFirst Aid Research Corporation2014-10-09Not applicableUs
Flexitol Medicated Anti-fungal CreamCream1 %TopicalLacorium Health International Pty Ltd.2008-09-12Not applicableCanada
Flexitol Medicated FootCream1 g/100gTopicalLacorium Health International Pty Ltd.2012-08-11Not applicableUs
Foot Care FoamAerosol, foam1 %TopicalNeubourg Skin Care Of North America Inc2015-09-30Not applicableCanada
Foot Works Healthy AntifungalPowder10 mg/gTopicalNew Avon Llc2013-04-24Not applicableUs
Foot Works Healthy AntifungalSpray10 mg/mLTopicalNew Avon Llc2011-12-19Not applicableUs
Footlogix Anti Fungal Mousse FormulaAerosol1 %TopicalKVG Group IncNot applicableNot applicableCanada
Footshield PlusCream1 g/100gTopicalQ.A. Laboratories2012-02-01Not applicableUs
Footworks Healthy Antifungal Powder for Athlete's FootPowder1 %TopicalAvon Products, Inc.2013-06-24Not applicableCanada
Footworks Healthy Antifungal Spray for Athlete's FootSpray1 %TopicalAvon Products, Inc.2012-02-29Not applicableCanada
Formucare Athletes Foot Maximum StrengthSpray1 g/100gTopicalAccess Business Group2004-11-11Not applicableUs
Formula 3Solution1 %TopicalThe Tetra Corporation2014-01-16Not applicableCanada
Formula 3Solution10 mg/mLTopicalThe Tetra Corporation2012-10-30Not applicableUs
Forticept Antifungal BalmLiquid10 g/1000gTopicalCosco International, Inc.2016-05-04Not applicableUs
Fulton Street Market Athletes FootCream1 g/100gTopicalAccess Business Group2009-08-14Not applicableUs
Fungablend 10Liquid10 mg/mLTopicalHappy Foot Shop, Llc2015-07-09Not applicableUs
FungicureGel10 mg/gTopicalAlva Amco Pharmacal Companies, Inc.1994-10-01Not applicableUs
Fungicure Anti-fungal Pump SprayLiquid1 %TopicalAlva Amco Pharmacal Companies, Inc.2002-01-192005-07-22Canada
Fungicure Athlete's Foot CreamCream1 %TopicalAlva Amco Pharmacal Companies, Inc.Not applicableNot applicableCanada
Fungicure Athletes FootCream10 mg/gTopicalAlva Amco Pharmacal Companies, Inc.2014-03-26Not applicableUs
Fungicure GelGel1 %TopicalAlva Amco Pharmacal Companies, Inc.1999-05-112016-08-04Canada
FungifoamAerosol, foam10 mg/mLTopicalThe Tetra Corporation2012-10-31Not applicableUs
Fungisolve Tolnaftate AntifungalSpray10 mg/mLTopicalDannso corp./d.b.a. Essential Products2011-03-16Not applicableUs
Fungisolve Tolnaftate AntifungalCream1 g/100gTopicalDannso corp./d.b.a. Essential Products2011-03-16Not applicableUs
Fungisolve Tolnaftate AntifungalLiquid10 mg/mLTopicalDannso corp./d.b.a. Essential Products2011-03-16Not applicableUs
Fungisolve Tolnaftate AntifungalCream1 g/100gTopicalDannso corp./d.b.a. Essential Products2011-03-16Not applicableUs
Fungoid-DCream1 g/100gTopicalPedinol Pharmacal, Inc.2011-08-01Not applicableUs
Fungus MdLiquid1 g/100mLTopicalOrly International Inc2014-07-18Not applicableUs
Fungus ReliefSolution10 mg/mLTopicalSwabplus Inc.2003-03-01Not applicableUs
Gadaderm AntifungalCream1 g/100gTopicalGadal Laboratories, Inc.2013-01-01Not applicableUs
Good Neighbor Pharmacy Athletes Foot ReliefSpray1 g/100gTopicalAmerisource Bergen2016-09-06Not applicableUs
Good Neighbor Pharmacy Athletes Foot ReliefSpray1 g/100gTopicalAmerisource Bergen2016-11-07Not applicableUs
Good Neighbor Pharmacy Maximum Strength Athletes Foot Relief AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-20Not applicableUs
Good Sense Athletes FootSpray1 g/100gTopicalL. Perrigo Company2005-06-14Not applicableUs
Good Sense Jock ItchSpray1 g/100gTopicalL. Perrigo Company2005-06-15Not applicableUs
Goodsense Athletes Foot AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-20Not applicableUs
Goodsense Powder Jock Itch AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-20Not applicableUs
Healthy Accents Athletes Foot AntifungalCream1 g/100gTopicalDza Brands,2010-07-21Not applicableUs
Hi VeticSolution1 g/100mLTopicalSato Pharmaceutical1990-08-14Not applicableUs
Hi VeticOintment1 g/100gTopicalSato Pharmaceutical1996-10-25Not applicableUs
Homehealth AntifungalLotion1 mL/100mLTopicalHome Health2011-02-14Not applicableUs
Hongo KillerPowder1 g/100gTopicalEfficient Laboratories, Inc.2000-01-01Not applicableUs
Hongo KillerAerosol, powder.1 g/10gTopicalEfficient Laboratories, Inc.2002-03-01Not applicableUs
Hongo Killer AntifungalCream.1 g/10gTopicalEfficient Laboratories, Inc.2000-01-01Not applicableUs
Hongo Killer AntifungalCream.1 g/10gTopicalEfficient Laboratories, Inc.2000-01-01Not applicableUs
Hongosan DspKitDsp Skin Care Products2016-07-09Not applicableUs
Joch Itch Antifungal QuinsanaPowder1 g/100gTopicalProduct Quest Mfg.2015-06-15Not applicableUs
Jock ItchSpray1 g/100gTopicalWalgreen2005-06-08Not applicableUs
Jock ItchSpray1 g/100gTopicalRite Aid2004-10-12Not applicableUs
Jock Itch ReliefSpray1 g/100gTopicalMeijer Distribution2017-03-29Not applicableUs
Kaiser Permanente TolnaftateCream10 mg/gTopicalKaiser Foundations Hospitals2006-02-17Not applicableUs
Keractil PlusGel10 mg/gTopicalPolimeros Y Servicios S.A.2016-03-09Not applicableUs
Kiss Fungi-gone Anti-fungal TreatmentLiquid10 mg/mLTopicalKiss Products, Inc.2012-10-23Not applicableUs
Lamisl AF DefenseAerosol, spray10 mg/gTopicalNovartis2006-02-01Not applicableUs
Lamisl AF DefenseCream10 mg/gTopicalNovartis2010-01-01Not applicableUs
Leader Antifungal TolnaftateCream10 mg/gTopicalCardinal Health2012-03-01Not applicableUs
Leader MedicatedAerosol, powder10 mg/gTopicalCardinal Health2008-03-15Not applicableUs
Meijer AntifungalCream10 mg/gTopicalMeijer Distribution2006-02-17Not applicableUs
Meijer Maximum Strength Anthletes Foot AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-20Not applicableUs
Meijer Maximum Strength Athletes Foot AntifungalLiquid10 mg/gTopicalFormulated Solutions, Llc2017-01-21Not applicableUs
Meijer Maximum Strength Jock Itch Relief AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-21Not applicableUs
Meijer TolnaftateCream10 mg/gTopicalMeijer2015-01-19Not applicableUs
Miracle Plus Anti-fungalCream.59 g/59gTopicalConcept Laboratories2011-01-042017-02-15Us
Miracle Plus Anti-fungal Foot ReliefCream.01 g/gTopicalConcept Laboratories2015-07-02Not applicableUs
Molecular AFOil.01 mg/mLTopicalRenu Laboratories, Inc.2011-07-01Not applicableUs
Nail Active Daytime Anti-fungalLotion100 g/gTopicalHarvest Trading Group Inc.2014-03-172017-02-15Us
Nail RenewLiquid1 g/100mLTopicalNail Renew2014-03-22Not applicableUs
Nailene Antifungal TreatmentLiquid10 mg/mLTopicalPacific World Corporation2013-04-24Not applicableUs
Natureplex Tolnaftate AntifungalCream10 mg/gTopicalNatureplex, LLC1993-09-23Not applicableUs
Odor Eaters Foot and SneakerSpray10 mg/gTopicalCombe Incorporated2001-09-01Not applicableUs
Odor-eatersAerosol1 %TopicalBlistex Corporation2002-03-07Not applicableCanada
Ongo - FinLiquid1 mL/100mLTopicalEfficient Laboratories, Inc.2004-02-01Not applicableUs
Personal Care AntifungalSpray1 g/100gTopicalPersonal Care Products2010-05-21Not applicableUs
Pitrex Crm 1%Cream1 %TopicalTaro Pharmaceuticals, Inc.1979-12-31Not applicableCanada
Premier Value Tolnaftate AntifungalCream10 mg/gTopicalChain Drug Consortium2012-01-20Not applicableUs
Proclearz Anti-fungal PenSolution1 %TopicalProfoot, Inc.Not applicableNot applicableCanada
Proclearz Antifungal LiquidLiquid1 %TopicalProfoot, Inc.1998-10-09Not applicableCanada
Proclearz Fungi-cide PMCream1 g/100gTopicalProfoot, Inc.2012-10-10Not applicableUs
Proclearz Maximum Strength Anti-fungal PenLiquid10 mg/mLTopicalProfoot, Inc.2012-10-23Not applicableUs
Proclearz Maximum Strength Fungal Shield Brush-ON AntifungalLiquid10 mg/mLTopicalEmilia Resources, Llc2017-03-10Not applicableUs
Proclearz Maximum Strength Fungal Shield Brush-ON AntifungalSolution10 mg/mLTopicalProfoot, Inc.2012-10-22Not applicableUs
Quality Choice Tolnaftate AntifungalCream1 g/100gTopicalChain Drug Marketing Association2013-05-31Not applicableUs
SanafitilCream1 g/100gTopicalPro Mex Llc2015-01-07Not applicableUs
Sanafitil CremaCream1 g/100gTopicalPro Mex Llc2015-01-07Not applicableUs
Signature Athletes Foot AntifungalPowder10 mg/gTopicalFormulated Solutions, Llc2017-01-21Not applicableUs
Signature Black Bottle Tea Tree Antifungal Foot and Body WashLotion10 mg/mLTopicalRestoration Rockstar, Llc (Dba: Kroning Signature Black Bottle)2016-02-10Not applicableUs
Signature Care AntifungalCream10 mg/gTopicalBetter Living Brands2015-08-26Not applicableUs
Signature Care Athletes FootSpray1 g/100gTopicalSafeway2015-10-11Not applicableUs
Signature Care Athletes FootSpray1 g/100gTopicalSafeway2015-11-23Not applicableUs
Signature Care Athletes Foot AntifungalLiquid10 mg/gTopicalFormulated Solutions, Llc2017-01-21Not applicableUs
Smart Sense Athletes FootSpray1 g/100gTopicalKmart Corporation2011-04-21Not applicableUs
Smart Sense Athletes Foot ReliefSpray1 g/100gTopicalKmart Corporation2016-04-12Not applicableUs
Smart Sense Tolnaftate AntifungalCream10 mg/gTopicalKmart Corporation2014-09-23Not applicableUs
Smart Sense Tolnftate AntifungalCream10 mg/gTopicalKmart Corporation2011-11-14Not applicableUs
Smartsense Maximum Strength Athletes Foot Relief AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-23Not applicableUs
Snap Stiks Athlete's Foot Relief Swabs With TolnaftateSwab1 %TopicalAms Homecare Inc.Not applicableNot applicableCanada
Snap-stiks Senior's Foot Fungus Relief Swabs With TolnaftateSwab1 %TopicalAms Homecare Inc.Not applicableNot applicableCanada
Soundbody Tolnaftate AntifungalCream10 mg/gTopicalUnited Exchange Corporation2014-02-26Not applicableUs
Sunmark AntifungalCream10 mg/gTopicalMc Kesson2006-02-17Not applicableUs
Sunmark Athletes Foot Liquid SpraySpray1 g/100gTopicalMc Kesson2005-06-16Not applicableUs
Sunmark Athletes Foot PowderSpray1 g/100gTopicalMc Kesson2005-06-16Not applicableUs
Swabplus Athlete's Foot Relief Swabs With TolnaftateSwab1 %TopicalSwabplus Inc.2003-06-152008-09-22Canada
Swabplus Fungus Relief Swabs With TolnaftateSwab1 %TopicalSwabplus Inc.2003-06-152008-09-22Canada
Target AntifungalCream10 mg/gTopicalTarget Corporation.2006-02-17Not applicableUs
TinactinCream10 mg/gTopicalFamar Montreal Inc1993-09-232017-05-04Us
TinactinAerosol, powder10 mg/gTopicalBayer1993-09-23Not applicableUs
TinactinPowder10 mg/gTopicalBayerl Health Care Llc1993-09-23Not applicableUs
TinactinCream10 mg/gTopicalBayer Health Care Llc.1993-09-23Not applicableUs
TinactinCream10 mg/gTopicalFamar Montreal Inc1993-09-232017-05-04Us
TinactinAerosol, powder10 mg/gTopicalBayer1993-09-23Not applicableUs
TinactinCream10 mg/gTopicalBayer Health Care Llc.1993-09-23Not applicableUs
TinactinCream1 %TopicalBayer Inc Consumer Care1965-12-31Not applicableCanada
TinactinAerosol, spray10 mg/gTopicalBayer1993-09-23Not applicableUs
Tinactin Aerosol PowderAerosol1 %TopicalBayer Inc Consumer Care1983-12-31Not applicableCanada
Tinactin AntifungalAerosol, powder10 mg/gTopicalBayer2014-02-28Not applicableUs
Tinactin AntifungalAerosol, powder10 mg/gTopicalBayer Health Care Llc.2011-10-01Not applicableUs
Tinactin Chill Deodorant Powder SprayAerosol1 %TopicalBayer Inc Consumer Care2009-07-18Not applicableCanada
Tinactin Chill Liquid SprayAerosol1 %TopicalBayer Inc Consumer Care2009-07-15Not applicableCanada
Tinactin Jock Itch Crm 10mg/gmCream10 mgTopicalSchering Plough1984-12-312006-08-01Canada
Tinactin Jock Itch Top Aer Pwr 10mg/gmPowder10 mgTopicalSchering Plough1984-12-312001-07-18Canada
Tinactin Liquid Aerosol 0.72mg/gmAerosol.72 mgTopicalSchering Plough1985-12-312001-07-18Canada
Tinactin Plus Areosol Powder 1%Aerosol1 %TopicalSchering Plough1992-12-312001-07-18Canada
Tinactin Plus Powder 1%Powder1 %TopicalSchering Plough1993-12-312001-07-18Canada
Tinactin PowderPowder1 %TopicalBayer Inc Consumer Care1965-12-31Not applicableCanada
Tinactin Pump SpraySpray1 %TopicalSchering Plough2001-05-012013-07-31Canada
Tinactin Sol 10mg/mlLiquid10 mgTopicalSchering Plough1964-12-312007-08-03Canada
Tinactin Super AbsorbentPowder10 mg/gTopicalBayer2015-03-01Not applicableUs
TineacideLiquid140 mg/15mLTopicalBlaine Labs Inc.2012-09-19Not applicableUs
TingAerosol, spray1.28 g/128gTopicalInsight Pharmaceuticals2009-07-27Not applicableUs
TingCream100 mg/gTopicalInsight Pharmaceuticals2009-06-08Not applicableUs
TolnafateAerosol, spray1.3 g/113gTopicalCvs Health2014-01-01Not applicableUs
TolnafateAerosol, spray1.3 g/130gTopicalCvs Health2017-05-22Not applicableUs
TolnafateAerosol, spray1.3 g/113gTopicalKroger2012-01-02Not applicableUs
TolnaftateCream10 mg/gTopicalMajor2010-02-11Not applicableUs
TolnaftateCream1 g/100gTopicalMorales Distributors, Inc.2012-09-25Not applicableUs
TolnaftateCream10 mg/gTopicalRemedy Repack2016-10-12Not applicableUs
TolnaftateCream1 g/100gTopicalKareway Product, Inc.2011-08-11Not applicableUs
TolnaftateAerosol, powder1.3 g/130gTopicalCvs Health2014-01-04Not applicableUs
TolnaftateAerosol, spray1.5 g/150gTopicalHarmon Store Inc.2012-02-14Not applicableUs
TolnaftateAerosol, spray1.3 g/113gTopicalFamily Dollar Services2012-01-01Not applicableUs
TolnaftateAerosol, spray1.13 g/113gTopicalTopco Associates2012-01-05Not applicableUs
TolnaftateCream10 mg/gTopicalLif Elabs, A Division Of Atico International, Usa, Inc.2010-11-01Not applicableUs
TolnaftateAerosol, spray1.5 g/150gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
TolnaftateCream1 g/100gTopicalNeopharm Co., Ltd2010-08-27Not applicableUs
TolnaftateAerosol, spray1.5 g/150gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
TolnaftateAerosol, spray1.3 g/113gTopicalChain Drug Consortium2006-06-01Not applicableUs
TolnaftateAerosol, powder1.3 g/130gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
TolnaftatePowder1 g/100gTopicalPerrigo New York Inc.2005-12-07Not applicableUs
TolnaftateSpray1.5 g/150gTopicalWalgreens2009-03-11Not applicableUs
TolnaftateAerosol, spray1.5 g/150.2gTopicalFamily Dollar Services2013-10-01Not applicableUs
TolnaftateAerosol, spray1.5 g/150.2gTopicalTarget Corporation.2008-12-31Not applicableUs
TolnaftateCream1 g/100gTopicalNavarro Discount Pharmacies, LLC2012-08-01Not applicableUs
TolnaftateAerosol, spray1.5 g/150gTopicalTopco Associates2012-01-03Not applicableUs
TolnaftateAerosol, spray1.3 g/113gTopicalHarmon Store Inc.2012-01-27Not applicableUs
TolnaftateAerosol, powder1.3 g/130gTopicalFamily Dollar Services2013-01-10Not applicableUs
TolnaftateAerosol, spray.13 g/130gTopicalChain Drug Consortium2003-05-23Not applicableUs
TolnaftateAerosol, spray1.3 g/130gTopicalTopco Associates2012-01-03Not applicableUs
TolnaftateCream1 g/100gTopicalA S Medication Solutions2011-08-022017-06-20Us
TolnaftateAerosol, powder1.3 g/130gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
TolnaftateCream1 g/100gTopicalPerrigo New York Inc.2011-08-02Not applicableUs
TolnaftateAerosol, spray1.5 g/150gTopicalCvs Health2014-01-01Not applicableUs
TolnaftateAerosol, spray1.3 g/130gTopicalTopco Associates2012-01-03Not applicableUs
TolnaftateCream1 %TopicalNexmed Usa IncNot applicableNot applicableCanada
TolnaftateAerosol, spray1.3 g/113gTopicalWalgreen2012-01-20Not applicableUs
TolnaftateCream1 g/100gTopicalTaro Pharmaceuticals, Inc.2009-08-20Not applicableUs
TolnaftateCream10 mg/gTopicalFaria Limited dba Sheffield Pharmaceuticals2009-10-07Not applicableUs
TolnaftateAerosol, powder1.1 g/113.3gTopicalTarget Corporation.2008-12-31Not applicableUs
TolnaftateAerosol, spray.13 g/130gTopicalChain Drug Consortium2004-04-23Not applicableUs
TolnaftateCream1 g/100gTopicalValue Merchandisers2012-03-01Not applicableUs
TolnaftateAerosol, powder1.3 g/113gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
TolnaftateCream1 g/100gTopicalDiscount Drug Mart2015-11-09Not applicableUs
TolnaftateAerosol, spray.15 g/150gTopicalChain Drug Consortium2003-05-23Not applicableUs
TolnaftateAerosol, spray1.3 g/113gTopicalMeijer Distribution2012-01-05Not applicableUs
TolnaftateCream10 mg/gTopicalA S Medication Solutions2010-02-112017-06-20Us
Tolnaftate AntifungalCream1 g/100gTopicalRemedy Repack2017-01-18Not applicableUs
Tolnaftate AntifungalPowder1 g/100gTopicalGericare Pharmaceuticals2011-08-01Not applicableUs
Tolnaftate AntifungalCream10 mg/gTopicalAmerisource Bergen2006-02-17Not applicableUs
Tolnaftate AntifungalCream1 g/100gTopicalTaro Pharmaceuticals U.S.A., Inc.1995-01-01Not applicableUs
Tolnaftate AntifungalPowder1 g/100gTopicalMajor2011-11-01Not applicableUs
Tolnaftate Antifungal CreamCream1 %TopicalGw Pharmaceuticals Ltd.2005-11-302011-08-22Canada
Tolnaftate Cream 1%Cream10 mg/gTopicalPharmacy Vlaue Alliance Llc2016-08-23Not applicableUs
Tolnaftate Cream 1% AntifungalCream1 g/100gTopicalTrifecta Pharmaceuticals Usa, Llc.2016-04-09Not applicableUs
Tolnaftate Cream USP 1% for Athlete's FootCream1.0 %TopicalCrlsNot applicableNot applicableCanada
Tolnaftate Cream USP, 1%Cream1 %TopicalTaro Pharmaceuticals, Inc.2010-03-10Not applicableCanada
Tolnaftate DCream1 g/100gTopicalNexmed Usa Inc2011-08-15Not applicableUs
Topcare Tolnaftate AntifungalCream10 mg/gTopicalTopco Associates2006-02-17Not applicableUs
Up and Up AntifungalSpray1 g/100gTopicalTarget Corporation.2017-06-28Not applicableUs
Up and Up Soothing AntifungalLiquid10 mg/gTopicalFormulated Solutions, Llc2017-01-23Not applicableUs
Villimed AntifungalLiquid10 mg/mLTopicalExtremity Healthcare Inc2016-12-20Not applicableUs
Walgreens Maximum Strength Jock Itch AntifungalSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-20Not applicableUs
Walgreens Medicated Antifungal Athletes FootSpray10 mg/gTopicalFormulated Solutions, Llc2017-01-23Not applicableUs
Walgreens TolnaftateCream10 mg/gTopicalWalgreen2011-05-04Not applicableUs
Western Family AntifungalCream10 mg/gTopicalWestern Family Foods2006-02-17Not applicableUs
Wick Storm Tea Tree Antifungal Foot Body WashLiquid10 mg/mLTopicalRestoration Rockstar Llc2015-07-10Not applicableUs
Winco Foods TolnaftateCream10 mg/gTopicalWinco Foods2015-02-06Not applicableUs
Woodwards Mycocide Clinical NSLiquid10 mg/mLTopicalPacific World Corporation2013-04-24Not applicableUs
Xtracare Antifungal FootSpray1 g/100gTopicalTaizhou Ludao Cosmetics Co., Ltd.2014-02-11Not applicableUs
Xtracare Antifungal FootSpray1 g/100gTopicalRejoice International2014-02-11Not applicableUs
Zeasorb AFPowder1 %TopicalGlaxosmithkline Inc1994-12-312014-02-20Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
AftateNot Available
Dr. Scholl's athlete's foot sprayNot Available
GenasporNot Available
Lamisil AFNot Available
NP-27Not Available
Odor EatersNot Available
PitrexNot Available
SeparinNot Available
TinadermNot Available
Brand mixtures
NameLabellerIngredients
Absorbine Jr Antifungal LiqClarion Brands, Llc
HeeltasticNeutraderm, Inc.
Nail MdOmg Medical Group, Llc
Categories
UNII06KB629TKV
CAS number2398-96-1
WeightAverage: 307.409
Monoisotopic: 307.103084861
Chemical FormulaC19H17NOS
InChI KeyFUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
IUPAC Name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
SMILES
CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
Pharmacology
Indication

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.

Structured Indications
Pharmacodynamics

Tolnaftate is a synthetic over-the-counter anti-fungal agent.

Mechanism of action

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

TargetKindPharmacological actionActionsOrganismUniProt ID
Squalene monooxygenaseProteinyes
inhibitor
YeastQ92206 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
Toxicity

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

Affected organisms
  • Yeast and other fungi
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AmlodipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Amlodipine.Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Tolnaftate.Approved, Investigational
AmrinoneThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Amrinone.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Azimilide.Investigational
BarnidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Barnidipine.Approved
BenidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Benidipine.Approved
BepridilThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Bepridil.Approved, Withdrawn
BuspironeThe metabolism of Buspirone can be decreased when combined with Tolnaftate.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Tolnaftate.Approved, Investigational
CarboxyamidotriazoleThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Cai.Investigational
CilnidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Cilnidipine.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Cinnarizine.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Tolnaftate.Approved, Investigational, Withdrawn
ClevidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Clevidipine.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Tolnaftate.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Tolnaftate.Approved, Investigational, Vet Approved
DarodipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Darodipine.Experimental
DidanosineDidanosine can cause a decrease in the absorption of Tolnaftate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DiltiazemThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Diltiazem.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Tolnaftate.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Tolnaftate.Approved
EfonidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Efonidipine.Approved
EperisoneThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Eperisone.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Tolnaftate.Approved
FelodipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Felodipine.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Fendiline.Withdrawn
FlunarizineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Flunarizine.Approved
FosphenytoinThe serum concentration of Tolnaftate can be decreased when it is combined with Fosphenytoin.Approved
GabapentinThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Gabapentin.Approved, Investigational
GallopamilThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Gallopamil.Investigational
IsradipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Isradipine.Approved
LacidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Lacidipine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Lamotrigine.Approved, Investigational
LercanidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Lercanidipine.Approved, Investigational
LosartanThe metabolism of Losartan can be decreased when combined with Tolnaftate.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Magnesium Sulfate.Approved, Vet Approved
ManidipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Manidipine.Approved
MibefradilThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Mibefradil.Withdrawn
NaftopidilThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Naftopidil.Investigational
NicardipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nicardipine.Approved
NifedipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nifedipine.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Niguldipine.Experimental
NiludipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Niludipine.Experimental
NilvadipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nilvadipine.Approved
NimesulideThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nimesulide.Approved, Withdrawn
NimodipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nimodipine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nisoldipine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Nitrendipine.Approved
PerhexilineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Perhexiline.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Tolnaftate.Approved, Vet Approved
PimozideTolnaftate may increase the arrhythmogenic activities of Pimozide.Approved
PinaveriumThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Pinaverium.Approved
PregabalinThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Prenylamine.Withdrawn
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Tolnaftate.Approved, Vet Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Tolnaftate.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Tolnaftate.Approved, Investigational
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Tolnaftate.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Tolnaftate.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Tolnaftate.Approved
RisedronateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Risedronate.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Tolnaftate.Approved
SucralfateSucralfate can cause a decrease in the absorption of Tolnaftate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Tolnaftate.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Tolnaftate.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Tolfenamic Acid.Approved
TranilastThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Tranilast.Approved, Investigational
VerapamilThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Verapamil.Approved
VinpocetineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Vinpocetine.Investigational
XylometazolineThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Xylometazoline.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Ziconotide.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Tolnaftate.Approved
Food InteractionsNot Available
References
Synthesis Reference

Chris E. Platt, "Topical preparation of tolnaftate and hydrocortisone to treat fungal infections of the skin." U.S. Patent US5496812, issued November, 1989.

US5496812
General References
  1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. [PubMed:8852337 ]
  2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. [PubMed:3524433 ]
External Links
ATC CodesD01AE18 — Tolnaftate
AHFS Codes
  • 84:04.08.40
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentAutoimmune Diseases / Disseminated or Multiple Sclerosis Nos / Disseminated Sclerosis / Multiple Sclerosis, Acute Relapsing / Multiple Sclerosis, Chronic Progressive / Multiple Sclerosis, Primary Progressive1
2, 3Not Yet RecruitingTreatmentCandidiasis infection1
3CompletedTreatmentDermatitis, Eczematous1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
LiquidTopical
LiquidTopical10 mg
PowderTopical.45 g/45g
SolutionTopical1 mg/100mL
GelTopical1 %
SprayTopical1 g/100g
AerosolTopical1 g/100g
SolutionTopical1 mL/100mL
CreamTopical.56 g/56.69g
SoapTopical1 g/100g
OilTopical.14 g/14g
LotionTopical.3 g/28g
Aerosol; powderTopical1 %
SprayTopical1 g/150g
Aerosol, foamTopical1 %
SprayTopical10 mg/mL
SprayTopical1 %
LiquidTopical10 g/1000g
GelTopical10 mg/g
Aerosol, foamTopical10 mg/mL
CreamTopical1 g/100g
SolutionTopical10 mg/mL
StickTopical
OintmentTopical1 g/100g
SolutionTopical1 g/100mL
LotionTopical1 mL/100mL
Aerosol, powderTopical.1 g/10g
CreamTopical.1 g/10g
Kit
Aerosol, sprayTopical10 mg/g
CreamTopical10 mg/g
Aerosol, powderTopical10 mg/g
LiquidTopical10 mg/g
CreamTopical.59 g/59g
CreamTopical.01 g/g
OilTopical.01 mg/mL
LotionTopical100 g/g
SprayTopical
LiquidTopical1 g/100mL
SprayTopical10 mg/g
LiquidTopical1 mL/100mL
SolutionTopical1 %
LiquidTopical1 %
LiquidTopical10 mg/mL
LotionTopical10 mg/mL
SwabTopical1 %
AerosolTopical1 %
CreamTopical10 mg
PowderTopical10 mg
AerosolTopical.72 mg
PowderTopical1 %
PowderTopical10 mg/g
LiquidTopical140 mg/15mL
Aerosol, sprayTopical1.28 g/128g
CreamTopical100 mg/g
Aerosol, powderTopical1.1 g/113.3g
Aerosol, powderTopical1.3 g/113g
Aerosol, powderTopical1.3 g/130g
Aerosol, sprayTopical.13 g/130g
Aerosol, sprayTopical.15 g/150g
Aerosol, sprayTopical1.13 g/113g
Aerosol, sprayTopical1.3 g/113g
Aerosol, sprayTopical1.3 g/130g
Aerosol, sprayTopical1.5 g/150.2g
Aerosol, sprayTopical1.5 g/150g
PowderTopical1 g/100g
SprayTopical1.5 g/150g
CreamTopical1.0 %
CreamTopical1 %
Prices
Unit descriptionCostUnit
Zeasorb-AF 2% Powder 70 gm Can14.99USD can
Zeasorb Powder 70.9 gm Can12.99USD can
Tolnaftate powder4.77USD g
Zeasorb-af 2% lotion0.19USD g
Zeasorb powder0.05USD g
Tinactin 1% aerosol0.04USD ml
Athlete's foot 1% liquid spray0.03USD g
Pv antifungal 1% spray liquid0.02USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)111 °CPhysProp
water solubility7.02e-05 mg/mL at 25 °CMEYLAN,WM et al. (1996)
logP5.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000546 mg/mLALOGPS
logP4.87ALOGPS
logP5.75ChemAxon
logS-5.8ALOGPS
pKa (Strongest Basic)0.075ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity94.92 m3·mol-1ChemAxon
Polarizability34.22 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9904
Blood Brain Barrier+0.9689
Caco-2 permeable+0.6348
P-glycoprotein substrateNon-substrate0.8667
P-glycoprotein inhibitor INon-inhibitor0.5537
P-glycoprotein inhibitor IINon-inhibitor0.857
Renal organic cation transporterNon-inhibitor0.8281
CYP450 2C9 substrateNon-substrate0.7363
CYP450 2D6 substrateNon-substrate0.6071
CYP450 3A4 substrateSubstrate0.6401
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorInhibitor0.8948
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9229
Ames testAMES toxic0.8449
CarcinogenicityNon-carcinogens0.7425
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7405 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8836
hERG inhibition (predictor II)Non-inhibitor0.5943
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Download (8.78 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-052b-0905000000-19e117da217d372632e2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00kb-0900000000-a065921efa544c82d972View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0006-9600000000-19faf0e6dcd285dad8d1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0002-0900000000-c4dd1b126170bea2c620View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-0002-0900000000-b026e71179265a982a40View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-00di-0900000000-a17707ff263e82d6e00eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-00di-3900000000-d0563822804c2844660bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-006x-9700000000-a217b6444068e1406235View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , positivesplash10-00kf-9200000000-dc89d8219d5ce2567f3cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-01ot-0901000000-c6fc83b073e80d5851f5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-qTof , PositiveNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
KingdomChemical entities
Super ClassOrganic compounds
ClassBenzenoids
Sub ClassNaphthalenes
Direct ParentNaphthalenes
Alternative ParentsToluenes / Thiocarbamic acid esters / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Hydrocarbon derivatives
SubstituentsNaphthalene / Toluene / Monocyclic benzene moiety / Thiocarbamic acid ester / Thiocarbamic acid derivative / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Hydrocarbon derivative / Organosulfur compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptorsmonothiocarbamic ester (CHEBI:9620 )

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Squalene monooxygenase activity
Specific Function:
Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Gene Name:
ERG1
Uniprot ID:
Q92206
Uniprot Name:
Squalene monooxygenase
Molecular Weight:
55297.635 Da
References
  1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. [PubMed:8852337 ]
  2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. [PubMed:3524433 ]
  3. Georgopapadakou NH, Bertasso A: Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. [PubMed:1416865 ]
Drug created on June 13, 2005 07:24 / Updated on July 18, 2017 16:50