Antifungals for Dermatological Use

DrugDrug NameDrug Description
DB00400GriseofulvinAn antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.
DB00525TolnaftateAn antifungal agent used to treat various skin infections caused by fungi.
DB00735NaftifineAn antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.
DB00793HaloproginUsed to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
DB00856ChlorphenesinA phenol ether used to treat painful muscular conditions.
DB00857TerbinafineAn allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.
DB00971Selenium SulfideAn antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.
DB01007TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
DB01091ButenafineA topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.
DB01110MiconazoleAn antifungal used to treat fungal infections affecting the vagina, mouth and skin.
DB01188CiclopiroxA broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.
DB04794BifonazoleUsed for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
DB06820SulconazoleA topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.
DB08933LuliconazoleA topical antifungal agent used to treat fungal infections.
DB09040EfinaconazoleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
DB09056AmorolfineAmorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol...
DB11117Undecylenic acidAn antifungal used to treat tinea species infections.
DB11368ChlorophetanolChlorophetanol is an agent known to have antifungal activities.
DB13302HachimycinNot Annotated
DB13360TolciclateNot Annotated
DB13434FenticonazoleNot Annotated
DB13459PecilocinNot Annotated
DB13513TribromometacresolNot Annotated
DB13603PyrrolnitrinNot Annotated
DB13611ChlormidazoleNot Annotated
DB13613TiclatoneNot Annotated
DB13628Ethyl hydroxybenzoateNot Annotated
DB13656EberconazoleNot Annotated
DB13671SulbentineNot Annotated
DB13696BromochlorosalicylanilideNot Annotated
DB13858DimazoleDimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.
DB00196FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
DB00239OxiconazoleA topical antifungal used to treat a variety of dermatophyte infections.
DB00257ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
DB00406Gentian violet cationAn antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.
DB00646NystatinA polyene antifungal used to treat cutaneous and mucocutaneous mycotic infections.
DB00730ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
DB00826NatamycinA macrolide antifungal used to treat fungal infections of the eye.
DB00936Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
DB01026KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
DB01099FlucytosineAn antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus.
DB01127EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
DB01153SertaconazoleA topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
DB08943IsoconazoleIsoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.
DB13425FlutrimazoleNot Annotated
DB13633MepartricinNot Annotated
DB13684OmoconazoleNot Annotated
DB09041TavaboroleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
DrugDrug NameTargetType
DB00400GriseofulvinTubulin beta chaintarget
DB00400GriseofulvinTubulin alpha chaintarget
DB00400GriseofulvinKeratin, type I cytoskeletal 12target
DB00400GriseofulvinCytochrome P450 1A2enzyme
DB00400GriseofulvinCytochrome P450 3A4enzyme
DB00525TolnaftateSqualene monooxygenasetarget
DB00735NaftifineSqualene monooxygenasetarget
DB00856ChlorphenesinCytochrome P450 19A1enzyme
DB00856ChlorphenesinCytochrome P450 3A4enzyme
DB00856ChlorphenesinXanthine dehydrogenase/oxidaseenzyme
DB00856ChlorphenesinProstaglandin G/H synthase 2enzyme
DB00856ChlorphenesinCholinesteraseenzyme
DB00857TerbinafineSqualene monooxygenasetarget
DB00857TerbinafineCytochrome P450 2D6enzyme
DB00857TerbinafineCytochrome P450 2C9enzyme
DB00857TerbinafineCytochrome P450 1A2enzyme
DB00857TerbinafineCytochrome P450 3A4enzyme
DB00857TerbinafineCytochrome P450 2C8enzyme
DB00857TerbinafineCytochrome P450 2C19enzyme
DB00857TerbinafineProstaglandin G/H synthase 1enzyme
DB01007TioconazoleLanosterol 14-alpha demethylasetarget
DB01007TioconazoleCytochrome P450 19A1enzyme
DB01007TioconazoleCytochrome P450 2C19enzyme
DB01007TioconazoleCytochrome P450 2E1enzyme
DB01007TioconazoleCytochrome P450 3A4enzyme
DB01007TioconazoleCytochrome P450 51target
DB01091ButenafineSqualene monooxygenasetarget
DB01110MiconazoleCytochrome P450 2C9enzyme
DB01110MiconazoleCytochrome P450 2D6enzyme
DB01110MiconazoleCytochrome P450 3A4enzyme
DB01110MiconazoleP-glycoprotein 1transporter
DB01110MiconazoleCytochrome P450 51target
DB01110MiconazoleNitric oxide synthase, endothelialtarget
DB01110MiconazoleNitric oxide synthase, inducibletarget
DB01110MiconazoleCalcium-activated potassium channel subunit alpha-1target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-1target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-2target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-3target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-4target
DB01110MiconazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 1target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 2target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 3target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 2target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 6target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 7target
DB01110MiconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01110MiconazoleCytochrome P450 2A6enzyme
DB01110MiconazoleCytochrome P450 2B6enzyme
DB01110MiconazoleCytochrome P450 2C19enzyme
DB01110MiconazoleCytochrome P450 2E1enzyme
DB01110MiconazoleNuclear receptor subfamily 1 group I member 2target
DB01110MiconazoleLanosterol 14-alpha demethylaseenzyme
DB01110MiconazoleCytochrome P450 19A1enzyme
DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
DB04794BifonazoleCytochrome P450 2B6target
DB04794BifonazoleCytochrome P450 51target
DB04794BifonazoleCytochrome P450 19A1enzyme
DB04794BifonazoleCytochrome P450 2E1enzyme
DB04794BifonazoleCytochrome P450 3A4enzyme
DB06820SulconazoleCytochrome P450 1A2enzyme
DB06820SulconazoleCytochrome P450 2C9enzyme
DB06820SulconazoleCytochrome P450 2D6enzyme
DB08933LuliconazoleCytochrome P450 51target
DB08933LuliconazoleCytochrome P450 3A4enzyme
DB08933LuliconazoleCytochrome P450 2C19enzyme
DB09040EfinaconazoleLanosterol 14-alpha demethylasetarget
DB00196FluconazoleCytochrome P450 3A4enzyme
DB00196FluconazoleCytochrome P450 2C9enzyme
DB00196FluconazoleCytochrome P450 2C19enzyme
DB00196FluconazoleP-glycoprotein 1transporter
DB00196FluconazoleCytochrome P450 51target
DB00196FluconazoleCytochrome P450 3A5enzyme
DB00239OxiconazoleCytochrome P450 51target
DB00239OxiconazoleLanosterol synthasetarget
DB00239OxiconazoleCytochrome P450 3A4enzyme
DB00239OxiconazoleCytochrome P450 2C19enzyme
DB00239OxiconazoleNuclear receptor subfamily 1 group I member 2target
DB00257ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB00257ClotrimazoleCytochrome P450 2D6enzyme
DB00257ClotrimazoleCytochrome P450 2C8enzyme
DB00257ClotrimazoleCytochrome P450 3A4enzyme
DB00257ClotrimazoleCytochrome P450 2B6enzyme
DB00257ClotrimazoleP-glycoprotein 1transporter
DB00257ClotrimazoleCytochrome P450 2A6enzyme
DB00257ClotrimazoleCytochrome P450 2C9enzyme
DB00257ClotrimazoleCytochrome P450 2E1enzyme
DB00257ClotrimazoleCytochrome P450 3A7enzyme
DB00257ClotrimazoleCytochrome P450 51target
DB00257ClotrimazoleNuclear receptor subfamily 1 group I member 2target
DB00257ClotrimazoleHydroxycarboxylic acid receptor 2target
DB00257ClotrimazoleBile salt export pumptransporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
DB00257ClotrimazoleErgosteroltarget
DB00406Gentian violet cationDNAtarget
DB00406Gentian violet cationSolute carrier family 22 member 1transporter
DB00646NystatinErgosteroltarget
DB00646NystatinSolute carrier organic anion transporter family member 1B1transporter
DB00646NystatinSolute carrier organic anion transporter family member 1B3transporter
DB00646NystatinCytochrome P450 3A4enzyme
DB00730ThiabendazoleFumarate reductase flavoprotein subunittarget
DB00730ThiabendazoleCytochrome P450 1A2enzyme
DB00730ThiabendazoleCytochrome P450 1A1enzyme
DB00826NatamycinErgosteroltarget
DB00826NatamycinCytochrome P450 3A4enzyme
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleP-glycoprotein 1transporter
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB01026KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
DB01026KetoconazoleCytochrome P450 4F12enzyme
DB01026KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
DB01026KetoconazoleSerum albumincarrier
DB01026KetoconazoleSex hormone-binding globulincarrier
DB01026KetoconazoleCytochrome P450 19A1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
DB01099FlucytosineThymidylate synthasetarget
DB01099FlucytosineDNA (cytosine-5)-methyltransferase 1target
DB01099FlucytosineDNAtarget
DB01127EconazoleCytochrome P450 19A1enzyme
DB01127EconazoleCytochrome P450 2E1enzyme
DB01127EconazoleCytochrome P450 3A4enzyme
DB01127EconazoleCytochrome P450 51target
DB01127EconazoleNuclear receptor subfamily 1 group I member 2target
DB01153SertaconazoleCytochrome P450 51target
DB13633MepartricinCytochrome P450 3A4enzyme
DB09041TavaboroleCytosolic leucyl-tRNA synthetasetarget